Fgf2

Summary

Gene Symbol: Fgf2
Description: fibroblast growth factor 2
Alias: Fgf-2, Fgfb, bFGF, fibroblast growth factor 2, HBGF-2, basic fibroblast growth factor, heparin-binding growth factor 2
Species: mouse

Top Publications

  1. pmc Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice
    R Dono
    EMBL, Heidelberg, Germany
    EMBO J 17:4213-25. 1998
  2. ncbi Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation
    B Garmy-Susini
    INSERM U589, Institut L Bugnard, CHU Rangueil, 31403 Toulouse, France
    Circ Res 94:1301-9. 2004
  3. ncbi Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone
    Wei Zheng
    Yale University, Child Study Center, New Haven, CT 06520, USA
    Dev Neurosci 26:181-96. 2004
  4. ncbi Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin
    Toshihiro Inoue
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto City, Japan
    Stem Cells 24:95-104. 2006
  5. pmc BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells
    Brent R DeGeorge
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 1:116-25. 2008
  6. pmc Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response
    Anna I Markowska
    Department of Ophthalmology Tufts University School of Medicine, Boston, MA 02115, USA
    J Exp Med 207:1981-93. 2010
  7. ncbi FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium
    W V Cardoso
    The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Dev Dyn 208:398-405. 1997
  8. pmc Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway
    Veronica C Ardi
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:25854-66. 2009
  9. pmc Allergen-induced coexpression of bFGF and TGF-β1 by macrophages in a mouse model of airway remodeling: bFGF induces macrophage TGF-β1 expression in vitro
    Hye Young Yum
    Department of Medicine, University of California San Diego, USA
    Int Arch Allergy Immunol 155:12-22. 2011
  10. pmc Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation
    Ruo Lang Pan
    College of Life Sciences, Zhejiang University, Hangzhou 310058, China
    J Biol Chem 286:12340-8. 2011

Research Grants

Scientific Experts

Detail Information

Publications140 found, 100 shown here

  1. pmc Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice
    R Dono
    EMBL, Heidelberg, Germany
    EMBO J 17:4213-25. 1998
    ..The observed autonomic dysfunction in FGF-2-deficient adult mice uncovers more general roles in neural development and function...
  2. ncbi Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation
    B Garmy-Susini
    INSERM U589, Institut L Bugnard, CHU Rangueil, 31403 Toulouse, France
    Circ Res 94:1301-9. 2004
    Both 17beta-estradiol (E2) and fibroblast growth factor-2 (FGF2) stimulate angiogenesis and endothelial cell migration and proliferation...
  3. ncbi Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone
    Wei Zheng
    Yale University, Child Study Center, New Haven, CT 06520, USA
    Dev Neurosci 26:181-96. 2004
    Cells within the subventricular zone (SVZ) express basic Fgf (Fgf2) and Fgf receptor proteins...
  4. ncbi Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin
    Toshihiro Inoue
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto City, Japan
    Stem Cells 24:95-104. 2006
    ..The proliferative effect of SB216763 was attenuated by an FGF receptor inhibitor but was enhanced by FGF2, with Ki-67-positive cells reaching over 70% of the total cells...
  5. pmc BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells
    Brent R DeGeorge
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 1:116-25. 2008
    ....
  6. pmc Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response
    Anna I Markowska
    Department of Ophthalmology Tufts University School of Medicine, Boston, MA 02115, USA
    J Exp Med 207:1981-93. 2010
    ..We demonstrate here that galectin-3 is a mediator of vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-mediated angiogenic response...
  7. ncbi FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium
    W V Cardoso
    The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Dev Dyn 208:398-405. 1997
    ..Thus, in the embryonic lung epithelium, growth effects of FGFs appear to be dependent on location of FGFRs, while effects on differentiation are ligand-dependent...
  8. pmc Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway
    Veronica C Ardi
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:25854-66. 2009
    ..By quantifying the levels of host angiogenic factors, we demonstrated that basic fibroblast growth factor (FGF-2) was a major cytokine becoming bioavailable in the onplant tissue undergoing a neutrophil ..
  9. pmc Allergen-induced coexpression of bFGF and TGF-β1 by macrophages in a mouse model of airway remodeling: bFGF induces macrophage TGF-β1 expression in vitro
    Hye Young Yum
    Department of Medicine, University of California San Diego, USA
    Int Arch Allergy Immunol 155:12-22. 2011
    b>Basic fibroblast growth factor (bFGF) is a cytokine that is mitogenic for fibroblasts and smooth muscle and may play a role in airway remodeling in asthma...
  10. pmc Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation
    Ruo Lang Pan
    College of Life Sciences, Zhejiang University, Hangzhou 310058, China
    J Biol Chem 286:12340-8. 2011
    ..Furthermore, we demonstrated that FGF2 was up-regulated in BM-MSCs under injury stimulation, and it probably participated in the inhibition of Dlk1 by BM-..
  11. ncbi Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis
    David Davidson
    Department of Medicine, Centre for Bone and Periodontal Research, McGill University, Montreal H3A 1A4, Canada
    J Biol Chem 280:20509-15. 2005
    ..This work, thus, identifies FGF18 and FGFR3 as potential molecular targets for intervention in tissue engineering aimed at cartilage repair and regeneration of damaged cartilage...
  12. pmc Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis
    Jay W Shin
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Biol Cell 17:576-84. 2006
    ..Together, these results indicate that FGFR-3 is an initial target of Prox1 during the lymphatic cell fate specification and that FGF signaling may play an important role in lymphatic vessel development...
  13. ncbi Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis
    Alda Vidrich
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia 22908, USA
    Dev Dyn 230:114-23. 2004
    ..FGFR-3 IIIb was the dominant isoform expressed in both small intestinal and colonic crypts. Expression of FGF1, FGF2, and FGF9, known ligands of FGFR-3, paralleled patterns of FGFR-3 expression during gut development...
  14. ncbi Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan
    V Nurcombe
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia
    Science 260:103-6. 1993
    ..Thus, a single species of HSPG undergoes a rapid, tightly controlled change in growth factor-binding specificity concomitant with the temporal expression of the FGFs...
  15. ncbi Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells
    P Kury
    Friedrich Miescher Institut, Basel, Switzerland
    Development 124:1251-62. 1997
    ..met-/mesencephalic junction were used to demonstrate a specific effect on transcriptional activity by basic fibroblast growth factor and Engrailed transcription factors, providing evidence that PN-1 is a target gene of these factors...
  16. ncbi Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth
    Y Wang
    Department of Pathology, University of Pittsburgh, Pennsylvania 15213, USA
    Nat Med 3:887-93. 1997
    Unlike normal melanocytes, primary and metastatic human melanomas express high levels of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) messenger RNA, and expression of these genes is essential in ..
  17. ncbi Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis
    Dianhua Qiao
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Clinical Sciences Center K4 850, Madison, WI 53562 8550, USA
    J Biol Chem 278:16045-53. 2003
    Fibroblast growth factor-2 (FGF2) is a potent angiogenic factor in gliomas. Heparan sulfate promotes ligand binding to receptor tyrosine kinase and regulates signaling...
  18. ncbi Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure
    Hyun Jung Kim
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, Korea
    Dev Dyn 227:335-46. 2003
    ..We observed that placing FGF2-soaked bead on the osteogenic fronts of cultured mouse calvaria accelerates cranial suture closure and strongly ..
  19. pmc Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis
    Chundong Yu
    Department of Biochemistry and Biophysics, Texas A and M University, and the Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Am J Pathol 163:1653-62. 2003
    ..role of all 23 FGF polypeptides in the liver is still unclear, the most widely studied prototypes, FGF1 and FGF2, are present and have been implicated in liver cell growth and function in vitro...
  20. ncbi Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse
    Alexandra A Blak
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
    Dev Dyn 233:1023-30. 2005
    ..Fgfr3 expression is in contact with the Fgf8 expression domain only in the rostroventral hindbrain. Based on these findings, we postulate a role for FGFR2 and FGFR3 in FGF signaling in the ventral midbrain and hindbrain...
  21. ncbi FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus
    Jørgen Wesche
    Institute for Cancer Research at The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    J Biol Chem 281:11405-12. 2006
    ..The data indicate that the drugs block translocation from endosomes to the cytosol implying that Hsp90 is required for translocation of FGF-1 and FGF-2 across the endosomal membrane...
  22. ncbi FGF2 alters expression of the pyrophosphate/phosphate regulating proteins, PC-1, ANK and TNAP, in the calvarial osteoblastic cell line, MC3T3E1(C4)
    Nan E Hatch
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    Connect Tissue Res 46:184-92. 2005
    ..Subsequently, the effect of FGF2 treatment on expression of PC-1, ANK, and TNAP in the calvarial osteoblastic cell line, MC3T3E1(C4), was ..
  23. ncbi Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    Federica Finetti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    J Biol Chem 283:2139-46. 2008
    ..Relevance for the FGF2-FGFR-1 system was highlighted by confocal analysis, showing receptor internalization after cell exposure to the ..
  24. ncbi Fibroblast growth factor influences the development and cycling of murine hair follicles
    D L du Cros
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195
    Dev Biol 156:444-53. 1993
    The effects of basic fibroblast growth factor (bFGF) on the development of hair follicles in neonatal mouse skin were examined...
  25. ncbi Fibroblast-growth-factor receptor mutations in human skeletal disorders
    M Muenke
    Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104 4399, USA
    Trends Genet 11:308-13. 1995
    ..Comparison of these specific mutations with the resulting phenotypes is now providing new insight into the role of these receptors in normal and abnormal bone development...
  26. pmc Fibroblast growth factor 2 control of vascular tone
    M Zhou
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Med 4:201-7. 1998
    ..Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers ..
  27. ncbi Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
    F M Vaccarino
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    Nat Neurosci 2:246-53. 1999
    We show that fibroblast growth factor 2 (FGF2) and FGF receptors are transiently expressed by cells of the pseudostratified ventricular epithelium (PVE) during early neurogenesis...
  28. ncbi Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
    A Hollnagel
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    J Biol Chem 274:19838-45. 1999
    ..cells responded very selectively to stimulation by various mesoderm inducers (BMP2/4, activin A, and basic fibroblast growth factor)...
  29. pmc Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation
    A Montero
    Department of Endocrinology and Metabolism, The University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Clin Invest 105:1085-93. 2000
    b>Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone growth and differentiation, is expressed and regulated in osteoblastic cells...
  30. ncbi Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex
    R Raballo
    Child Study Center and Section of Neurobiology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 20:5012-23. 2000
    ..We have previously shown that the germline mutation of the basic fibroblast growth factor (Fgf2) gene results in a reduction in the number of cortical neurons in the adult...
  31. ncbi Novel fibroblast growth factor 2 transcripts are expressed in mouse embryos
    R P Dirks
    Department of Anatomy, University of Wisconsin Medical School, Madison, WI 53706, USA
    Biochem Biophys Res Commun 287:900-9. 2001
    We have discovered two new exons in the mouse fibroblast growth factor 2 (FGF-2 or bFGF) gene that can be alternatively spliced to the second coding exon of the gene...
  32. ncbi Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants
    Bernhard Reuss
    Department of Neuroanatomy, IZN, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 23:6404-12. 2003
    ..The observed defect in astroglial differentiation is accompanied by a defect in BBB function arguing for an indirect or direct role of FGFs in the regulation of BBB permeability in vivo...
  33. ncbi MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element
    Oscar L Sierra
    Department of Internal Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 279:32913-23. 2004
    ..with endogenous Runx2 and FGFR2), MINT augments transcription driven by the OCFRE that is further enhanced by FGF2 treatment. OCFRE regulation can be reconstituted in the naïve CV1 fibroblast cell background...
  34. ncbi Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site
    Shigetada Teshima-Kondo
    Institut National de la Santé et de la Recherche Médicale U589, Hormones, Facteurs de Croissance et Physiopathologie Vasculaire, Institut Louis Bugnard IFR31, Hopital Rangueil, Toulouse, France
    FASEB J 18:1583-5. 2004
    b>Fibroblast growth factor 2 (FGF-2) is normally synthesized at low levels but is elevated in various pathophysiological conditions including diabetes-associated vascular diseases...
  35. ncbi Testosterone regulates FGF-2 expression during testis maturation by an IRES-dependent translational mechanism
    Irma G Gonzalez-Herrera
    Institut National de la Santé et de la Recherche Médicale U589, Toulouse, France
    FASEB J 20:476-8. 2006
    Spermatogenesis is a complex process involving cell proliferation, differentiation, and apoptosis. Fibroblast growth factor 2 (FGF-2) is involved in testicular function, but its role in spermatogenesis has not been fully documented...
  36. ncbi Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells
    Chai Fei Li
    Laboratory of Cell Growth, Northern California Institute for Research and Education, San Francisco, California, USA
    J Bone Miner Res 21:946-55. 2006
    ..Here, we show that MS induced proliferation in both MC3T3-E1 and BMOp cells isolated from Fgf2(+/+) mice; Fgf2(-/-) BMOp cells required exogenous FGF-2 for a normal proliferation response...
  37. ncbi Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3
    Maura Camozzi
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy
    J Biol Chem 281:22605-13. 2006
    ..PTX3 binds fibroblast growth factor-2 (FGF2), inhibiting its pro-angiogenic and pro-restenotic activity...
  38. ncbi FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential state
    Natalina Quarto
    Department of Surgery, School of Medicine, Stanford University, Stanford, California 94305 5148, USA
    Tissue Eng 12:1405-18. 2006
    ..These FGF-2 functional characteristics may assist with cell selection and enrichment for the purpose of bone tissue engineering...
  39. pmc The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling
    Siyun Liao
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 42:106-20. 2007
    Our laboratory showed that overexpression of fibroblast growth factor-2 (FGF2) protected the heart against ischemia-reperfusion injury...
  40. ncbi Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion
    Marco Timmer
    Department of Neuroanatomy, Hannover Medical School, Center for Systems Neuroscience Hannover, 30625 Hannover, Germany
    J Neurosci 27:459-71. 2007
    b>Basic fibroblast growth factor (FGF-2) is involved in the development and maintenance of the nervous system. Exogenous administration of FGF-2 increased dopaminergic (DA) graft survival in different animal models of Parkinson's disease...
  41. ncbi Dura mater-derived FGF-2 mediates mitogenic signaling in calvarial osteoblasts
    Shuli Li
    Children s Surgical Research Program, Department of Surgery Stanford University, School of Medicine, Stanford, CA 94305 5148, USA
    Am J Physiol Cell Physiol 293:C1834-42. 2007
    ....
  42. pmc Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones
    Natalina Quarto
    Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, Calif 94305 5148, USA
    Cells Tissues Organs 190:158-69. 2009
    ..Frontal bone also elaborated higher levels of Fgf receptor 1, 2 and 3 transcripts versus parietal bone. Taken together, these data suggest that the frontal bone is a domain with higher FGF-signaling competence than parietal bone...
  43. pmc Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells
    Liping Xiao
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 47:360-70. 2010
    Here we determine the Fibroblast Growth Factor-2 (FGF2) dependency of the time course of changes in bone mass in female mice...
  44. pmc The function of FGF signaling in the lens placode
    Claudia M Garcia
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63110, USA
    Dev Biol 351:176-85. 2011
    ..Since the expression of proteins required for lens formation was not altered in the knockout placode cells, we can conclude that FGF signaling from the optic vesicle is not required for lens induction...
  45. doi S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    J Cell Sci 124:2389-400. 2011
    ..Here, we show that S100B increases and/or stabilizes the binding of basic fibroblast growth factor (bFGF) to bFGF receptor 1 (FGFR1) by interacting with bFGF, thereby enhancing FGFR1 activation and the ..
  46. doi Fibroblast growth factor 2 regulates adequate nigrostriatal pathway formation in mice
    Olga Baron
    Institute of Neuroanatomy, Hannover Medical School, 30625 Hannover, Germany
    J Comp Neurol 520:3949-61. 2012
    b>Fibroblast growth factor 2 (FGF-2) is an important neurotrophic factor that promotes survival of adult mesencephalic dopaminergic (mDA) neurons and regulates their adequate development...
  47. doi FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression
    Mi Ran Byun
    Department of Life Sciences, Korea University, Seoul 136 701, Republic of Korea
    Bone 58:72-80. 2014
    ..Within this family, FGF2 stimulates osteoblast differentiation though a mechanism that is largely unknown...
  48. doi EGF-FGF2 stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs)
    Raul Bardini Bressan
    Departamento de Biologia Celular, Embriologia e Genetica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario Trindade, 88040 900 Florianopolis SC, Brazil
    Exp Cell Res 327:37-47. 2014
    ..Since the combination of epidermal growth factor (EGF) and fibroblast growth factor type 2 (FGF2) is mitogenic and promotes the neuronal commitment of various stem cell populations, we examined its effects in the ..
  49. pmc Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells
    Agnes Lukaszewicz
    Institut National de la Santé et de la Recherche Médicale U371, Cerveau et Vision, 69675 Bron, France
    J Neurosci 22:6610-22. 2002
    b>Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neurotrophin 3 (NT3) promotes differentiation in these cells...
  50. pmc Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene
    Kesi Chen
    Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT 06520, USA
    BMC Neurosci 9:94. 2008
    The Fgf2 gene is expressed in the brain neuroepithelium during embryonic development and in astroglial cells throughout life...
  51. ncbi Fibroblast growth factor 2 is necessary for the growth of glutamate projection neurons in the anterior neocortex
    Sailaja Korada
    Child Study Center and Department of Neurobiology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 22:863-75. 2002
    b>Basic fibroblast growth factor (Fgf2) is required for the generation of founder cells within the dorsal pseudostratified ventricular epithelium, which will generate the cerebral cortex, but the ganglionic eminences are not affected...
  52. pmc Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice
    D L Miller
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 20:2260-8. 2000
    Fibroblast growth factor 1 (FGF1) and FGF2, the prototypic members of the FGF family of growth factors, have been implicated in a variety of physiological and pathological processes...
  53. ncbi STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
    M Sahni
    Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA
    Development 128:2119-29. 2001
    ..We crossed Stat1(-/-) mice with a transgenic mouse line overexpressing human FGF2 (TgFGF)...
  54. ncbi FGF2 signaling is required for the development of neuronal circuits regulating blood pressure
    Rosanna Dono
    Department of Developmental Biology, Faculty of Biology, Utrecht University, Utrecht, The Netherlands
    Circ Res 90:E5-E10. 2002
    b>Fibroblast growth factor 2 (FGF2) signaling is involved in angiogenesis, vascular contractility, and cardiac hypertrophy...
  55. ncbi Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential
    Wande Li
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    J Cell Biochem 88:152-64. 2003
    ..Here we demonstrate that basic fibroblast growth factor (bFGF), a polypeptide which regulates proliferation, differentiation, and migration of a variety of ..
  56. ncbi Efficient cardiomyogenic differentiation of embryonic stem cell by fibroblast growth factor 2 and bone morphogenetic protein 2
    Takao Kawai
    Cardiology, Respiratory and Nephrology, Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, Gifu, Japan
    Circ J 68:691-702. 2004
    ..The aim of the present study was to investigate whether growth factors may efficiently enhance the in vitro cardiac differentiation of ES cells...
  57. ncbi Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung
    Amanda E Serls
    Department of Pathology, University of Colorado Health Sciences Center, The Children s Hospital, 1056 East 19th Avenue, Denver, CO 80218, USA
    Development 132:35-47. 2005
    ..of cardiac mesoderm, ventral foregut endoderm explants respond to exogenous fibroblast growth factor (FGF) 1 and FGF2 in a dose-dependent manner, with lower concentrations activating liver specific genes and higher concentrations ..
  58. ncbi Expression pattern of matrix metalloproteinase and TIMP genes in fibroblasts derived from Ets-1 knock-out mice compared to wild-type mouse fibroblasts
    Jens Claus Hahne
    Institute of Pathology, University of Bonn, 53011 Bonn, Germany
    Int J Mol Med 18:153-9. 2006
    ..We stimulated wild-type mouse fibroblasts with physiological doses of basic fibroblast growth factor (bFGF, known to induce different proteases and expressed by tumour cells) and compared the results to ..
  59. pmc Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
    Lars Johan Nissen
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 117:2766-77. 2007
    ..Here we show that 2 angiogenic factors frequently upregulated in tumors, PDGF-BB and FGF2, synergistically promote tumor angiogenesis and pulmonary metastasis...
  60. pmc Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor
    Monica M Montano
    Department of Pharmacology, Case Western Reserve University School of Medicine, H G Wood Bldg W307, 2109 Adelbert Rd, Cleveland, Ohio 44106, USA
    Circ Res 102:415-22. 2008
    ..The basis for this role of HEXIM1 is that VEGF is a direct transcriptional target of HEXIM1, and involves attenuation a repressive effects of C/EBPalpha on VEGF gene transcription...
  61. doi Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1
    Haijie Yang
    Research Laboratories, National Neuroscience Institute, Singapore 308433
    J Biol Chem 283:5287-95. 2008
    ..However, the underlying mechanisms remain largely unknown. In this report, we have demonstrated that basic fibroblast growth factor (bFGF) alone effectively induces mouse BMSC neuronal differentiation...
  62. doi Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression
    Luis G Rabaneda
    Area de Fisiologia, Facultad de Medicina, Universidad de Cadiz, Cadiz, Spain
    FASEB J 22:3823-35. 2008
    ..We show that Hcy exerts an antiproliferative effect on basic fibroblast growth factor (bFGF) -stimulated NPCs isolated from the postnatal subventricular zone (SVZ), accompanied by ..
  63. doi Fibroblast growth factor 2 regulates dopaminergic neuron development in vivo
    Andreas Ratzka
    Institute of Neuroanatomy, Hannover Medical School, Hannover, Germany
    J Neurochem 122:94-105. 2012
    b>Fibroblast growth factor 2 (FGF-2) is a neurotrophic factor participating in regulation of proliferation, differentiation, apoptosis and neuroprotection in the central nervous system...
  64. pmc Differential regulation of CXCL5 by FGF2 in osteoblastic and endothelial niche cells supports hematopoietic stem cell migration
    Kyung Ae Yoon
    Department of Oral Pathology, School of Dentistry, IHBR, Kyungpook National University, Daegu, Korea
    Stem Cells Dev 21:3391-402. 2012
    ..The systemic administration of FGF2 failed to induce normal hematopoiesis in bone marrow (BM) by reducing SDF-1, an important factor for hematopoiesis...
  65. doi Atorvastatin-induced increase in progenitor cell levels is rather caused by enhanced receptor activator of NF-kappaB ligand (RANKL) cell proliferation than by bone marrow mobilization
    Martin Steinmetz
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    J Mol Cell Cardiol 57:32-42. 2013
    ..Osteoclast/osteoblast interaction has been associated with progenitor cell mobilization. Here, we investigated the role of statins on progenitor cell mobilization with a focus on bone metabolism...
  66. pmc Cardiac development and physiology are modulated by FGF2 in an isoform- and sex-specific manner
    Eyad Nusayr
    Department of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson AZ
    Physiol Rep 1:. 2013
    The low molecular weight isoform (Lo) of fibroblast growth factor 2 (FGF2) has distinct functions from the high molecular weight isoforms (Hi) of FGF2 in the adult stressed heart...
  67. pmc Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing
    Eric Sterner
    From the Department of Chemical and Biological Engineering
    J Biol Chem 289:9754-65. 2014
    ..These data were used to examine the two proposed signaling models, the symmetric FGF2-HS2-FGFR2 ternary complex model and the asymmetric FGF2-HS1-FGFR2 ternary complex model...
  68. pmc Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway
    Jing Yang
    a Department of Reproductive Endocrinology Women s Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China
    Cell Cycle 14:3318-30. 2015
    Fibroblast growth factors (FGF1, FGF2 and FGF4) and fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3 and FGFR4) have been reported to be expressed in preimplantation embryos and be required for their development...
  69. pmc BCL11B regulates sutural patency in the mouse craniofacial skeleton
    Kateryna Kyrylkova
    Department of Pharmaceutical Sciences, College of Pharmacy, USA
    Dev Biol 415:251-60. 2016
    ....
  70. ncbi The neurobeachin gene (Nbea) identifies a new region of homology between mouse central chromosome 3 and human chromosome 13q13
    D J Gilbert
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Mamm Genome 10:1030-1. 1999
  71. ncbi The presence of FGF2 signaling determines whether beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells
    Nipan Israsena
    Department of Neurology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Dev Biol 268:220-31. 2004
    Neural stem cells proliferate and maintain multipotency when cultured in the presence of FGF2, but subsequent lineage commitment by the cells is nevertheless influenced by the exposure to FGF2...
  72. ncbi The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair
    Hans Dietmar Beer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Oncogene 24:5269-77. 2005
    ....
  73. ncbi Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation
    Zhifeng Xiao
    Peking University Stem Cell Research Center and Cell Biology Department, Peking University Health Science Center, Beijing, China
    Cell Res 17:73-9. 2007
    ..Since both vascular and glial cells secrete vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), we assessed the effect of VEGF and bFGF on NSC proliferation using nearly homogeneous NSCs ..
  74. pmc Chemical control of FGF-2 release for promoting calvarial healing with adipose stem cells
    Matthew D Kwan
    Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 286:11307-13. 2011
    ..We placed fibroblast growth factor 2 (FGF-2) under conditional control of a small molecule and demonstrated greater than 50-fold regulation ..
  75. pmc Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-γ
    Byung Jae Lee
    Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Exp Mol Med 43:169-78. 2011
    ..Transgenic studies have demonstrated that high levels of IFN-γ in the airways induce emphysema. Fibroblast growth factor 2 (FGF2), which is the downstream mediator of TGF-β, is important in wound healing...
  76. doi A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal
    Norihisa Bizen
    Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University TMDU, Tokyo, Japan
    Stem Cells 32:1602-15. 2014
    ..We have proposed a model previously explaining partly this linkage, in which fibroblast growth factor 2 (FGF2) and Wnt signals cooperate to promote NSC self-renewal via β-catenin accumulation, which leads to ..
  77. doi FGF-2 signal promotes proliferation of cerebellar progenitor cells and their oligodendrocytic differentiation at early postnatal stage
    Masae Naruse
    Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Biochem Biophys Res Commun 463:1091-6. 2015
    ..These results suggest that CD44-positive cells might be a source of cerebellar oligodendrocytes and that FGF-2 plays important roles in their development at an early postnatal stage. ..
  78. pmc Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
    D D Spitkovsky
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Nucleic Acids Res 20:797-803. 1992
    ..Finally, we have identified four YB-1 related loci in the mouse genome and have mapped these loci to four different mouse chromosomes by interspecific backcross analysis...
  79. doi Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma
    Takatsune Shimizu
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Mol Cancer Res 10:454-68. 2012
    ..osteosarcoma model was used to clarify the roles of environmental factors such as fibroblast growth factor-2 (Fgf2) or leukemia-inhibitory factor (Lif) in the maintenance of osteosarcoma cells in an immature state...
  80. pmc Renal collecting system growth and function depend upon embryonic γ1 laminin expression
    Dong Hua Yang
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 138:4535-44. 2011
    ..mRNA levels for fibroblast growth factor 2 (FGF2) and mediators of the GDNF/RET and WNT11 signaling pathway were also decreased...
  81. pmc ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts
    Corinne Niger
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 302:C1035-44. 2012
    ..Previously, we have shown that Cx43 can enhance the signaling and transcriptional response to fibroblast growth factor 2 (FGF2) in osteoblasts by increasing protein kinase C-δ (PKCδ) activation to affect Runx2 activity...
  82. pmc Low molecular weight fibroblast growth factor-2 signals via protein kinase C and myofibrillar proteins to protect against postischemic cardiac dysfunction
    Janet R Manning
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Am J Physiol Heart Circ Physiol 304:H1382-96. 2013
    Among its many biological roles, fibroblast growth factor-2 (FGF2) acutely protects the heart from dysfunction associated with ischemia/reperfusion (I/R) injury...
  83. ncbi Temporal and quantitative analysis of myogenic regulatory and growth factor gene expression in the developing mouse embryo
    K Hannon
    Department of Biotechnology Research, Lilly Research Laboratories, Indianapolis, Indiana 46285
    Dev Biol 151:137-44. 1992
    ..5 dpc, while bFGF was not detected until 10.5 dpc...
  84. ncbi Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice
    H Gao
    Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Biol 169:168-84. 1995
    ..5, and 22 kDa of bFGF protein isolated from the adult retina. A bioassay indicates that this putative basic fibroblast growth factor (bFGF) stimulates proliferation of BALB/c 3T3 fibroblasts in a dose-dependent manner identical to an ..
  85. ncbi Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse
    S Werner
    Max Planck Institut fur Biochemie, Martinsried, Germany
    J Invest Dermatol 103:469-73. 1994
    ....
  86. ncbi Inner ear basic fibroblast growth factor in CBA/J, C3H/HeJ, and autoimmune Palmerston north mice
    A D Pedersen
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, Portland 97201 2997
    Hear Res 66:253-9. 1993
    b>Basic fibroblast growth factor (bFGF) has a mitogenic effect on fibroblasts and osteoblasts for matrix proliferation and on endothelial cells for neovascularization...
  87. ncbi Basic FGF as an inducer of anteroposterior neural pattern
    T Doniach
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0724, USA
    Cell 83:1067-70. 1995
  88. ncbi Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis
    A Kurtz
    Vincent T Lombardi Cancer Center and Department of Pharmacology, Georgetown University, Washington, DC 20007, USA
    Oncogene 14:2671-81. 1997
    ..Finally, mouse FGF-BP binds to FGF-2 and can function as a modulator of FGF in FGF-responsive cells. Our results suggest a potential function of FGF-BP during development and tumorigenesis...
  89. ncbi Basic fibroblast growth factor (FGF-2) in mouse tooth morphogenesis
    L G Russo
    Department of Structure, Function and Biotechnology, Faculty of Veterinary Medicine, University of Naples Federico II, Italy
    Growth Factors 15:125-33. 1998
    This study describes the spatio-temporal expression of basic Fibroblast growth factor (FGF-2) during odontogenesis of mouse as revealed by immunohistology...
  90. ncbi Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase
    S Haul
    Institute of Neurophysiology, University of Dusseldorf, D 40001 Dusseldorf, Germany
    J Neurophysiol 81:494-7. 1999
    ..No LTP could be induced in knockout mice lacking the endothelial NOS (eNOS) isoform. These data suggest that eNOS is involved in an NMDA receptor-independent form of LTP in the rodent cerebral cortex...
  91. ncbi Neurotrophic signaling in normal and degenerating rodent retinas
    K J Wahlin
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9277, USA
    Exp Eye Res 73:693-701. 2001
    ..These data add to the mounting evidence suggesting that neurotrophic factors act indirectly through Müller cells to promote photoreceptor survival...
  92. ncbi Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE
    Alessandro Foletti
    ISREC Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Oncogene 21:1841-7. 2002
    We have analysed the importance of fibroblast growth factor 2 (FGF2) in tumor development...
  93. pmc Dose-dependent response of FGF-2 for lymphangiogenesis
    Lynn K Chang
    Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:11658-63. 2004
    ..We revisited this concept by using fibroblast growth factor 2 (FGF-2) (80 ng) to stimulate the growth of both vessel types in the mouse cornea...
  94. pmc HSF4 is required for normal cell growth and differentiation during mouse lens development
    Mitsuaki Fujimoto
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube 755 8505, Japan
    EMBO J 23:4297-306. 2004
    ....
  95. ncbi Alterations in seizure susceptibility and in seizure-induced plasticity after pharmacologic and genetic manipulation of the fibroblast growth factor-2 system
    Silvia Zucchini
    Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, Ferrara, Italy
    Epilepsia 46:52-8. 2005
    ..The aim of this minireview is to summarize and discuss the data supporting the idea that FGF-2 may be involved in seizure generation and in their sequelae...
  96. ncbi Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants
    J Jungnickel
    Hannover Medical School, Department of Neuroanatomy, Germany
    Neuroscience 134:1343-50. 2005
    The presence and regulation of basic fibroblast growth factor and its high-affinity tyrosine kinase receptor FGFR3 in sensory neurons during development and after peripheral nerve injury suggest a physiological role of the fibroblast ..
  97. ncbi Adipose tissue engineering based on the controlled release of fibroblast growth factor-2 in a collagen matrix
    Aditya V Vashi
    Bernard O Brien Institute of Microsurgery, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Tissue Eng 12:3035-43. 2006
    ..In conclusion, this study has shown that de novo formation of adipose tissue can be achieved through controlled release of FGF-2 in collagen type I in the absence of Matrigel...
  98. ncbi Fibroblast growth factor-2 in hyperplastic pituitaries of D2R knockout female mice
    Carolina Cristina
    Instituto de Biologia y Medicina Experimental, CONICET, V Obligado 2490, 1428, Buenos Aires, Argentina
    Am J Physiol Endocrinol Metab 293:E1341-51. 2007
    ..Our objective was to study the expression of the mitogen fibroblast growth factor (FGF2) and its receptor, FGFR1, comparatively in pituitaries from KO and wild-type (WT) female mice...
  99. pmc Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge
    Sailay Siddiqi
    San Diego State University Heart Institute and Department of Biology, San Diego State University, CA 92182, USA
    Circ Res 103:89-97. 2008
    ....
  100. doi Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2
    Catarina Figueiredo
    Centro Biologia Desenvolvimento, Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    J Neurochem 107:73-85. 2008
    ..We suggest that FGF-2 plays a pivotal role in neuroprotection against QA as an outcome of neuron-microglia interaction...
  101. doi Expandable endodermal progenitors: new tools to explore endoderm and its derivatives
    Henrik Semb
    Stem Cell Center, Lund University, BMC B10, S 221 84 Lund, Sweden
    Cell Stem Cell 3:355-6. 2008
    ..2008) used a reporter gene strategy to isolate replicating anterior definitive endoderm from mESCs...

Research Grants3

  1. The University of Connecticut BRIDGES Network
    Marja Hurley; Fiscal Year: 2006
    ..An evaluation format has been designed to monitor the success of the program. Computerized records of student status and progress will be logged into NIH ESTAR and used for tracking outcomes. ..
  2. REMYELINATION AND AXON INTEGRITY IN CHRONIC DEMYELINATION
    Regina C Armstrong; Fiscal Year: 2010
    ..Importantly, our preliminary data in FGF2-I- mice demonstrates that it is possible to overcome chronic lesion effects on endogenous oligodendrocyte lineage ..
  3. BASIC FIBROBLAST GROWTH FACTOR EXPRESSION IN BONE CELLS
    Marja Hurley; Fiscal Year: 2003
    b>Basic fibroblast growth factor (FGF-2), a potent mitogen for osteoblasts and marrow stromal cells, is synthesized by bone cells...