Fcer1a

Summary

Gene Symbol: Fcer1a
Description: Fc receptor, IgE, high affinity I, alpha polypeptide
Alias: FcERI, Fce1a, Fcr-5, fcepsilonri, high affinity immunoglobulin epsilon receptor subunit alpha, fc-epsilon RI-alpha, igE Fc receptor subunit alpha
Species: mouse

Top Publications

  1. ncbi IL-9 induces expression of granzymes and high-affinity IgE receptor in murine T helper clones
    J Louahed
    Ludwig Institute for Cancer Research, University of Louvain, Brussels, Belgium
    J Immunol 154:5061-70. 1995
  2. ncbi Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 173:4317-23. 2004
  3. pmc FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation
    David A Mancardi
    Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    J Clin Invest 118:3738-50. 2008
  4. doi The spectrum of chronic urticaria
    Umer Najib
    Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02445, USA
    Allergy Asthma Proc 30:1-10. 2009
  5. pmc Interaction between activated chemokine receptor 1 and FcepsilonRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells
    Nimita H Fifadara
    Dobbs Ocular Immunology Laboratories, Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int Immunol 22:113-28. 2010
  6. ncbi The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase
    Christine Tkaczyk
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:48474-84. 2003
  7. ncbi Anaphylaxis mediated through a humanized high affinity IgE receptor
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:1645-51. 1996
  8. pmc Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Clin Invest 99:915-25. 1997
  9. pmc IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice
    Jing Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 121:3564-77. 2011
  10. ncbi Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses
    D Dombrowicz
    Laboratory of Allergy and Immunology, Beth Israel Deaconess Medical Center, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 8:517-29. 1998

Scientific Experts

  • Barbara Platzer
  • Tatsuki R Kataoka
  • S M McAleese
  • S Kubo
  • D A Underhill
  • Nimita H Fifadara
  • Mindy Tsai
  • Bruce D Wines
  • M Daeron
  • Satoshi Nunomura
  • David A Mancardi
  • Pierre Bruhns
  • Keigo Nishida
  • Toshiaki Kawakami
  • Bruno Iannascoli
  • Chisei Ra
  • D Dombrowicz
  • Jiro Kitaura
  • Yuko Kawakami
  • Shoko Iwaki
  • Friederike Jönsson
  • Christian Taube
  • Christine Tkaczyk
  • Hajime Karasuyama
  • Stephen J Galli
  • David Dombrowicz
  • Juan Rivera
  • Toshio Hirano
  • Satoru Yamasaki
  • Kai Ting C Shade
  • Magali Noval Rivas
  • Yun Jung Lee
  • Peter A Nigrovic
  • Chun Yu Chen
  • Bryce A Binstadt
  • Günther Baravalle
  • Hans C Oettgen
  • Koki Kabu
  • Guo Ping Shi
  • Galina K Sukhova
  • Peter Libby
  • Noah W Palm
  • Christine D Pozniak
  • Alasdair M Gilfillan
  • Thomas Marichal
  • Dean D Metcalfe
  • Clifford A Lowell
  • Marcello Albanesi
  • Michael A Beaven
  • Ryo Suzuki
  • Riccardo Sibilano
  • Shinya Hidano
  • Nicholas A Pullen
  • Wenbin Xiao
  • Eik Hoffmann
  • Adeline Porcherie
  • Nico Van Rooijen
  • Yoshimichi Okayama
  • Archana S Iyer
  • Jing Wang
  • Jian Gong
  • Asifa K Zaidi
  • Qing Hui Wang
  • Janet Kalesnikoff
  • Laurence E Cheng
  • Jean Pierre Kinet
  • J P Kinet
  • Elisa A Nigro
  • Daisuke Endo
  • M Akimoto
  • Peter N Pushparaj
  • Umer Najib
  • Georges Abboud
  • Sebastien Fleury
  • John J Ryan
  • Brian O Barnstein
  • Aiko Hasegawa
  • Ryo Goitsuka
  • Daisuke Kitamura
  • Raif S Geha
  • Taku Kambayashi
  • Kristy Roth
  • James Hunt
  • Andrea Denzel
  • Mor Li Hartman
  • Guido Hansen
  • Susumu Nakae
  • Michele A Grimbaldeston
  • Lien H Ho
  • Alexander Iain Taylor

Detail Information

Publications99

  1. ncbi IL-9 induces expression of granzymes and high-affinity IgE receptor in murine T helper clones
    J Louahed
    Ludwig Institute for Cancer Research, University of Louvain, Brussels, Belgium
    J Immunol 154:5061-70. 1995
    ..Several T cell clones expressed this IgE receptor mRNA and were able to bind IgE with high affinity. Taken together, our results indicate that IL-9 induces a mast cell-like phenotype in T cell clones...
  2. ncbi Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 173:4317-23. 2004
    ..Monomeric IgE binding to its high affinity receptor (FcepsilonRI) results in a number of biological outcomes in mouse mast cells, including increased surface expression of ..
  3. pmc FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation
    David A Mancardi
    Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    J Clin Invest 118:3738-50. 2008
    ..and peritoneal macrophages to secrete cytokines, suggesting that mFcgammaRIV may be an equivalent of human FceRI(alphagamma), which is expressed by macrophages and neutrophils and especially in atopic individuals, rather than ..
  4. doi The spectrum of chronic urticaria
    Umer Najib
    Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02445, USA
    Allergy Asthma Proc 30:1-10. 2009
    ..There is evidence of an autoantibody to the high-affinity receptor for IgE (FcepsilonRI), specifically binding to the alpha-chain (FcepsilonRIalpha), which may be pathogenic...
  5. pmc Interaction between activated chemokine receptor 1 and FcepsilonRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells
    Nimita H Fifadara
    Dobbs Ocular Immunology Laboratories, Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int Immunol 22:113-28. 2010
    ..We examined the effects of FcepsilonRI-chemokine receptor (CCR) 1 co-stimulation on receptor localization and cellular morphology of bone marrow-..
  6. ncbi The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase
    Christine Tkaczyk
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:48474-84. 2003
    ..However, PI 3-kinase may contribute to the later phase of Fc epsilon RI-mediated degranulation in human mast cells...
  7. ncbi Anaphylaxis mediated through a humanized high affinity IgE receptor
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:1645-51. 1996
    ..a combination of transgenic and embryonic stem cell technology to generate a mouse line in which the murine Fc epsilon RI alpha-chain has been replaced with its human homologue...
  8. pmc Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Clin Invest 99:915-25. 1997
    ....
  9. pmc IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice
    Jing Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 121:3564-77. 2011
    ..This study reveals what we believe to be several previously unrecognized IgE activities that affect arterial cell biology and likely other IgE-associated pathologies in human diseases...
  10. ncbi Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses
    D Dombrowicz
    Laboratory of Allergy and Immunology, Beth Israel Deaconess Medical Center, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 8:517-29. 1998
    ..FcRbeta is a subunit common to the high-affinity IgE (FcepsilonRI) and low-affinity IgG (FcgammaRIII) receptors, both of which contribute to the initiation of allergic reactions...
  11. doi Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI
    Mor Li Hartman
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Immunol 45:2307-11. 2008
    ..These findings show that the extracellular domain of the type I transmembrane protein Fc epsilon RI alpha plays a role in Fc epsilon RI intracellular processing and expression at the cell surface.
  12. pmc Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia
    Mitchell H Grayson
    Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Exp Med 204:2759-69. 2007
    ..Therefore, lung DC expression of FcepsilonRIalpha is part of the antiviral response that recruits CD4(+) T cells and drives mucous cell metaplasia, thus linking antiviral responses to allergic/asthmatic Th2 responses...
  13. ncbi Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells
    C Ra
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892
    J Biol Chem 264:15323-7. 1989
    ..The subunits are completely interchangeable upon transfection so that various chimeric mouse-rat-human receptors can be expressed...
  14. ncbi Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    Nat Immunol 8:1095-104. 2007
    ....
  15. ncbi Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852
    Cell 75:969-76. 1993
    ..Therefore, interfering with its function should be an effective means of treating allergy, regardless of the allergen specificity...
  16. pmc TGF-beta 1 inhibits mast cell Fc epsilon RI expression
    Gregorio Gomez
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:5987-93. 2005
    Mast cell activation through the high affinity IgE receptor (FcepsilonRI) is a critical component of atopic inflammation...
  17. pmc Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells
    Shoko Iwaki
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1881, Bethesda, MD 20892 1881, USA
    Cell Signal 20:195-205. 2008
    ..The observations reported herein support the conclusion that NTAL may be differentially utilized by specific receptors for relaying alternative signals and this suggests a flexibility in the function of TRAPs not previously appreciated...
  18. ncbi Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses
    Jiangfeng Sun
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 179:6696-703. 2007
    ..We investigated the relative contribution of Igs, mast cells (MCs), and FcepsilonRI in the elicitation of anaphylaxis in a murine model...
  19. doi Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo
    Peter N Pushparaj
    Glasgow Biomedical Research Centre, University of Glasgow, Scotland, United Kingdom
    J Immunol 183:221-7. 2009
    ..b>FcepsilonRI-mediated degranulation has contradictorily been shown to require SphK1 or SphK2, depending on the reports...
  20. pmc Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria
    Adeline Porcherie
    Institut Pasteur, Unité de Biologie des Interactions Hôte Parasites, Paris, France
    J Exp Med 208:2225-36. 2011
    ..These data define a new pathogenic mechanism of ECM and implicate an FcεRI-expressing neutrophil subpopulation in malaria disease severity...
  21. doi SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils
    Shinya Hidano
    Division of Development and Aging, Research Institute for Biological Sciences, 2669 Yamazaki, Noda, Chiba 278 0022, Japan
    Int Immunol 24:719-27. 2012
    ..Taken together, these findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcεRI and the IL-3 receptor...
  22. doi The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L
    Satoshi Nunomura
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, Tokyo 173 8610, Japan
    J Immunol 188:4052-64. 2012
    ..Taken together, our results suggest crucial and distinct functions for the FcRβ- and γ-ITAMs in the FcεRI-dependent full activation of mast cells induced by IgEκ and PpL...
  23. pmc Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:2325-30. 2007
    ..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis...
  24. doi Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma
    Marcello Albanesi
    Institut Pasteur, corrected Département d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, corrected 75015 Paris, France
    J Immunol 189:5513-7. 2012
    ..Our finding that mouse FcγRIII contributes to Ab-induced tumor reduction correlates with clinical data on its human functional equivalent human FcγRIIIA (CD16A)...
  25. pmc Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
    Christine D Pozniak
    Department of Neuroscience, 2 Department of Biomedical Imaging, 3 Department of Bioinformatics and Computational Biology, 4 Department of Protein Chemistry, 5 Department of Pathology, Genentech, Inc, South San Francisco, CA 94080
    J Exp Med 210:2553-67. 2013
    ....
  26. pmc A beneficial role for immunoglobulin E in host defense against honeybee venom
    Thomas Marichal
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 39:963-75. 2013
    ....
  27. pmc Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity
    Noah W Palm
    Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 39:976-85. 2013
    ..These data suggest that the innate immune system can detect the activity of a conserved component of venoms and induce a protective immune response against a venom toxin. ..
  28. pmc Antigen-conjugated human IgE induces antigen-specific T cell tolerance in a humanized mouse model
    Günther Baravalle
    Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143
    J Immunol 192:3280-8. 2014
    ..Thus, targeting FcεRI on DCs via Ag-Fcε fusion protein may serve an alternative method to induce Ag-specific T cell tolerance in humans. ..
  29. pmc Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites
    B Platzer
    Division of Gastroenterology and Nutrition, Boston Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 8:516-32. 2015
    ..Our study demonstrates a novel immune regulatory function of IgE and proposes that DC-intrinsic IgE signals serve as a feedback mechanism to restrain allergic tissue inflammation. ..
  30. doi CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα
    Tatsuki R Kataoka
    Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    Int Immunol 27:95-103. 2015
    ..6 activated Cbl-b, down-regulated KIT expression and suppressed the mutated KIT-driven growth of these cells. Thus, the mechanism by which CD72 mediates inhibitory effects in mast cells is species-dependent. ..
  31. doi Treatment of murine mast cells with IgEκ and protein L enhances apoptotic cell death induced by IL-3 withdrawal
    Satoshi Nunomura
    Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan Allergy and Immunology Group, Research Institute of Medical Science, Nihon University School of Medicine, Tokyo, Japan Electronic address
    Biochem Biophys Res Commun 456:700-5. 2015
    ..These findings suggest that PpL increases IL-3 withdrawal-induced ACD of IgEκ-sensitized BMMCs by incorporating PpL into the BMMCs and that this internalized PpL may interfere with survival signals via FcεRI...
  32. pmc Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy
    Magali Noval Rivas
    Division of Immunology, Boston Children s Hospital, Boston, MA 02115, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Immunity 42:512-23. 2015
    ..Interruption of Th2 cell reprogramming of Treg cells might thus provide candidate therapeutic strategies in food allergy...
  33. pmc A single glycan on IgE is indispensable for initiation of anaphylaxis
    Kai Ting C Shade
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129
    J Exp Med 212:457-67. 2015
    ..These results underscore an unappreciated and essential requirement of glycosylation in IgE biology. ..
  34. pmc Functions of dendritic-cell-bound IgE in allergy
    Barbara Platzer
    Division of Gastroenterology and Nutrition, Boston Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA Electronic address
    Mol Immunol 68:116-9. 2015
    ....
  35. pmc Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice
    Yun Jung Lee
    Department of Medicine Y J L, C L, M L, G K S, K I, A S B, P L, G P S, Brigham and Women s Hospital and Harvard Medical School, Department of Genetics and Complex Diseases K I, School of Public Health, Harvard University, and Department of Cell Biology J S, R N K, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02115 Department of Cardiology C L, Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, People s Republic of China Institute of Cardiology M L, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430072, People s Republic of China and NutriOmique team M A, S A, K C, Institute of Cardiometabolism and Nutrition, INSERM, Unité Mixte de Recherche en Santé Unité 1166, and NutriOmique team M A, S A, K C, Universite Pierre et Marie Curie Paris 6, Paris F 75013 France
    Endocrinology 156:4047-58. 2015
    ..IgE receptor FcϵR1-deficient (Fcer1a(-/-)) mice and diet-induced obesity (DIO) mice demonstrated that FcϵR1 deficiency in DIO mice increased food ..
  36. pmc Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy
    Chun Yu Chen
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Immunity 43:788-802. 2015
    ..Thus, the induction of MMC9s is a pivotal step to acquire the susceptibility to IgE-mediated food allergy...
  37. pmc Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3
    Y W Wong
    Medical Research Council Cellular Immunology Research Unit, Sir William Dunn School of Pathology, University of Oxford, England
    J Exp Med 171:2115-30. 1990
    ....
  38. ncbi Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19
    K Hupp
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    J Immunol 143:3787-91. 1989
    ..gene for FC epsilon RI gamma is found at the distal end of mouse chromosome 1, clustered in a region where Fc epsilon RI alpha has also been linked to Fc gamma RII...
  39. ncbi Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1
    W S Moseley
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 5:899-905. 1989
    ..These studies provide a model for examination of specific evolutionary events...
  40. pmc Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production
    Nicholas A Pullen
    Department of Biology, Virginia Commonwealth University, Richmond, Virginia 23284, USA
    J Biol Chem 287:2045-54. 2012
    ..Altogether, these data implicate Fyn as the major positive mediator of STAT5 after FcεRI engagement and demonstrate importantly distinct roles for STAT5A and STAT5B in mast cell function...
  41. pmc Autonomous phagosomal degradation and antigen presentation in dendritic cells
    Eik Hoffmann
    Institut National de la Santé et de la Recherche Médicale U932, Institut Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 109:14556-61. 2012
    ..Phagosomal autonomy could serve as a basis for the intracellular discrimination between self and nonself antigens, resulting in the preferential presentation of peptides derived from opsonized, nonself antigens...
  42. doi Modulation of FcεRI-dependent mast cell response by OX40L via Fyn, PI3K, and RhoA
    Riccardo Sibilano
    Department of Medical and Biological Sciences, University of Udine, Udine, Italy
    J Allergy Clin Immunol 130:751-760.e2. 2012
    ..Little is known on OX40L-mediated intracellular signaling or on the mechanism by which OX40L engagement suppresses MC degranulation...
  43. ncbi Localization of the mouse gene encoding tyrosine kinase receptor type 10 on distal chromosome 1
    J N Murdoch
    Neural Development Unit, University College London, UK
    Mamm Genome 8:941-2. 1997
  44. pmc Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses
    Archana S Iyer
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 286:9503-13. 2011
    ..Network analysis suggests that although they may share substrates, Itk plays both positive and negative roles, while Btk primarily plays a positive role in mast cell FcεRI-induced cytokine secretion...
  45. pmc Murine B cells regulate serum IgE levels in a CD23-dependent manner
    Laurence E Cheng
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Immunol 185:5040-7. 2010
    ..B cells captured IgE by direct binding to the low-affinity IgE receptor, CD23. These data indicate a mechanism regulating serum IgE and additionally clarify the role of CD23 in this process...
  46. pmc Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice
    Mindy Tsai
    Stanford University School of Medicine, Department of Pathology, L 235, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Am J Pathol 177:2411-20. 2010
    ....
  47. pmc The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcepsilonRI and MHC II
    Jian Gong
    Department of Allergy and Immunology, IgE Therapeutics, Inc, San Diego, CA, USA
    BMC Immunol 11:34. 2010
    ..Evidence is presented for a novel surface FcepsilonRIhi , MHC II +, and c-kit + pure mast cell subset, temporally restricted as antigen-presenting cells in the immune axis of T-cell activation...
  48. doi Opposite effects of Trichostatin A on activation of mast cells by different stimulants
    Qing Hui Wang
    Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    FEBS Lett 584:2315-20. 2010
    Mast cells (MCs) are activated upon stimulation via TLRs or FcepsilonRI, contributing to immune protection and/or leading to allergic diseases...
  49. ncbi Fc receptor biology
    M Daeron
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U 255, Institut Curie, Paris, France
    Annu Rev Immunol 15:203-34. 1997
    ..FcR therefore appear as the subunits of multichain receptors whose constitution is not predetermined and which deliver adaptative messages as a function of the environment...
  50. doi Regulation of Fc epsilon RI expression during murine basophil maturation: the interplay between IgE, cell division, and Fc epsilon RI synthetic rate
    Asifa K Zaidi
    Division of Allergy and Clinical Immunology, Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Immunol 184:1463-74. 2010
    ..The studies also support a model whereby receptor expression is limited by cell division and that basophils, once mature, slow their rate of receptor synthesis...
  51. doi Antitumor IgE adjuvanticity: key role of Fc epsilon RI
    Elisa A Nigro
    Department of Biology and Genetics, University of Milan, Milan, Italy
    J Immunol 183:4530-6. 2009
    ..This finding suggests that the adjuvant effect of IgE could be exploited for human therapeutics...
  52. ncbi Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE
    Shuichi Kubo
    Department of Laboratory Animal Science, Tokyo Metropolitan Organization for Medical Science, Tokyo Metropolitan Institute of Medical Science, Japan
    J Immunol 170:775-80. 2003
    ..However, they can acquire Ag specificity through binding of Ag-specific IgE to FcepsilonRI expressed on their surface...
  53. doi PI3Kgamma differentially regulates FcepsilonRI-mediated degranulation and migration of mast cells by and toward antigen
    Daisuke Endo
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Tokyo 173 8610, Japan
    Int Arch Allergy Immunol 149:66-72. 2009
    ..3-kinase (PI3K) has been recognized as an important downstream effector of high-affinity receptor for IgE (FcepsilonRI) signaling in mast cells, but little is known about the isoform specificity of PI3Ks on the FcepsilonRI-..
  54. doi Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice
    Georges Abboud
    Institut National de la Santé et de la Recherche Médicale Unité 547, Institut Pasteur de Lille, and Université Lille 2, Lille, France
    J Immunol 182:6517-26. 2009
    ..Targeting both IgE/Fc(epsilon)RI and IgG/CD16 interactions might represent an efficient therapeutic strategy for allergic diseases...
  55. doi Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis
    David A Mancardi
    Departement d Immunologie, Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, F 75015 Paris, France
    J Immunol 186:1899-903. 2011
    ....
  56. pmc Mouse and human neutrophils induce anaphylaxis
    Friederike Jönsson
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    J Clin Invest 121:1484-96. 2011
    ..These molecules and cells could be potential new targets for the development of anaphylaxis therapeutics if the same mechanism is responsible for anaphylaxis in humans...
  57. doi Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation
    Keigo Nishida
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    J Immunol 187:932-41. 2011
    ..ARF1 activity was required for FcεRI-mediated granule translocation. These data indicated that Fyn/Gab2/PI3K/ARF1-mediated signaling is specifically involved in granule translocation and the anaphylaxis response...
  58. doi Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses
    M Akimoto
    Department of Immunology and Signal Transduction, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo, Japan
    Scand J Immunol 69:401-11. 2009
    ..Ptpre) plays key regulatory roles during mast-cell activation mediated by the high-affinity IgE receptor (FcepsilonRI)...
  59. pmc Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
    I Miyajima
    Department of Pathology, Beth Israel Deaconess Medical Center East and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 99:901-14. 1997
    ....
  60. ncbi Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells
    P S Costello
    National Institute for Medical Research, London, UK
    Oncogene 13:2595-605. 1996
    ..A similar mechanism is likely to apply to signal transduction through all members of the antigen receptor family...
  61. ncbi Receptors for Fc epsilon and Fc gamma are linked on mouse chromosome 1
    K Huppi
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    J Immunol 141:2807-10. 1988
    Recently isolated cDNA clones for the high affinity Fc epsilon receptors on mast cells and basophils (Fc epsilon RI alpha) and Fc gamma receptors on macrophages and lymphocytes (Fc gamma 2b/gamma 1R) are homologous members of the Ig ..
  62. ncbi A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E
    J P Kinet
    Section on Chemical Immunology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892
    Biochemistry 26:4605-10. 1987
    ..The sequence shows no homology with the low-affinity receptor for IgE from lymphocytes but over 30% homology with an Fc gamma receptor...
  63. pmc A 6000 kb segment of chromosome 1 is conserved in human and mouse
    S F Kingsmore
    Department of Medicine, Duke University Medical Center, Durham, NC 27710
    EMBO J 8:4073-80. 1989
    ..In addition, these findings demonstrate profound conservation of genomic organization over mammalian evolution...
  64. ncbi mRNA variants encoding multiple forms of the high-affinity IgE receptor alpha subunit in transformed and nontransformed mast cells
    M W Robertson
    Medical Biology Institute, La Jolla, Calif
    Int Arch Allergy Appl Immunol 96:289-95. 1991
    ..Finally, mRNA variants have been translated in a cell-free system and the protein products partially characterized...
  65. ncbi Structure of the gene for the alpha-chain of the mouse high affinity receptor for IgE (Fc epsilon RI)
    Z S Ye
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 149:897-900. 1992
    ..Comparison with other Fc receptor genes (rat Fc epsilon RI, mouse Fc gamma RIII alpha, human Fc gamma RIIIB and human Fc gamma RIIIA alpha) revealed a high degree of gene organization conservation...
  66. ncbi Different stabilities of the structurally related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their alpha-chains
    Toshiyuki Kubota
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Immunol 176:7008-14. 2006
    A variant of the high affinity IgE receptor FcepsilonRI, which is composed of alpha- and gamma-chains without the beta-chain, is expressed on human APC, such as dendritic cells, and has been suggested to facilitate Ag uptake through IgE ..
  67. pmc Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells
    Andrew W B Craig
    Department of Biochemistry, Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Mol Cell Biol 22:6363-74. 2002
    ..Further studies with mast cells derived from fps/fes-deficient mice will be required to provide insight into the role of Fps/Fes in mast cell activation...
  68. ncbi Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:6398-406. 2004
    ..To define the role of the high affinity IgE receptor (FcepsilonRI) in the development of AHR, mice with a disruption of the alpha subunit of the high affinity IgE receptor (..
  69. ncbi IgE-dependent mast cell activation potentiates airway responses in murine asthma models
    Susanne I Mayr
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 169:2061-8. 2002
    ..Since FcepsilonRI is expressed mainly on mast cells in mouse airways, we conclude that IgE-dependent activation of this cell type ..
  70. pmc Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane
    Keigo Nishida
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Kanagawa 230 0045, Japan
    J Cell Biol 170:115-26. 2005
    The aggregation of high affinity IgE receptors (Fcepsilon receptor I [FcepsilonRI]) on mast cells is potent stimulus for the release of inflammatory and allergic mediators from cytoplasmic granules...
  71. pmc FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells
    Huihong Qiao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760, USA
    Blood 107:610-8. 2006
    ..The synergistic interactions of TLR ligands and antigen might have relevance to the exacerbation of IgE-mediated allergic diseases by infectious agents...
  72. ncbi Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit
    Shoko Iwaki
    Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1881, USA
    J Biol Chem 280:40261-70. 2005
    ..These data demonstrate, for the first time, that Btk is a key regulator of a Kit-mediated amplification pathway that augments Fc epsilonRI-mediated mast cell activation...
  73. pmc Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:6885-92. 2005
    Aggregation of the high affinity receptor for IgE (FcepsilonRI) induces activation of mast cells...
  74. ncbi Particularities of the vasculature can promote the organ specificity of autoimmune attack
    Bryce A Binstadt
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:284-92. 2006
    ..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders...
  75. ncbi The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 176:3157-64. 2006
    ..Together, these data define the important role for mast cells and the LTB4-BLT1 pathway in the development of CD8+ T cell-mediated allergic responses in the lung...
  76. ncbi A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI
    Bruce D Wines
    Helen Macpherson Smith Trust Inflammatory Disease Laboratory, The Macfarlane Burnet Institute for Medical Research and Public Health, Austin Health Campus, Heidelberg, Victoria 3084, Australia
    J Biol Chem 281:17108-13. 2006
    ..in the TM region of the FcRgamma subunit are important for association with the high affinity IgE receptor FcepsilonRI and a leukocyte receptor cluster member, the IgA receptor FcalphaRI...
  77. ncbi Zinc is required for Fc epsilon RI-mediated mast cell activation
    Koki Kabu
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology RCAI, Yokohama, Kanagawa, Japan
    J Immunol 177:1296-305. 2006
    ..The granules of MCs contain various chemical mediators and inflammatory cytokines that are released upon FcepsilonRI cross-linking. In this study, we report that Zn is essential for MC activation both in vitro and in vivo...
  78. ncbi Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA
    R J Oakey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710
    Hum Mol Genet 1:613-20. 1992
    ..These data support the use of comparative mapping in physical map construction and further suggest the value of using mouse genetics to help define human disease loci...
  79. ncbi The nucleotide sequence of dinitrophenyl-specific IgE and Fc(epsilon)RI alpha-subunit obtained from FE-3 hybridoma cells
    Y Tokeshi
    1st Department of Physiology, School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Hybrid Hybridomics 20:361-8. 2001
    ....
  80. doi Positive and negative regulatory mechanisms in high-affinity IgE receptor-mediated mast cell activation
    Kristy Roth
    Department of Microbiology and Immunology, Dalhousie University, 5850 University Ave, Halifax, NS, Canada B3K6R8
    Arch Immunol Ther Exp (Warsz) 56:385-99. 2008
    ..The aggregation of the high-affinity IgE receptor (FcepsilonRI) on the surface of mast cells initiates a complex cascade of signaling events that ultimately leads to the ..
  81. ncbi Sequence and expression analysis of Nhlh1: a basic helix-loop-helix gene implicated in neurogenesis
    J N Murdoch
    Neural Development Unit, University College London, UK
    Dev Genet 24:165-77. 1999
    ..Nhlh1 has been implicated previously as a candidate for the neural tube defect mutant loop-tail (Lp); here, we present sequence and expression data indicating that Nhlh1 is unlikely to be responsible for the Lp mutation...
  82. pmc Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo
    James Hunt
    King s College London, Medical Research Council, Randall Division of Cell and Molecular Biophysics, Guy s Campus, London SE1 1UL, United Kingdom
    J Biol Chem 283:29882-7. 2008
    The high affinity of IgE for its receptor, FcepsilonRI (K(a) approximately 10(10) M(-1)), is responsible for the persistence of mast cell sensitization...
  83. doi The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
    Guido Hansen
    Biota Structural Biology Laboratory, St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Cell 134:496-507. 2008
    ..This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors, providing a structural basis for understanding their mechanism of activation and for the development of therapeutics...
  84. doi Basophils enhance immunological memory responses
    Andrea Denzel
    Department of Internal Medicine II, University Hospital Regensburg, 93042 Regensburg, Germany
    Nat Immunol 9:733-42. 2008
    ..These basophil-dependent effects on B cells required interleukins 6 and 4 and increased the capacity of CD4(+) T cells to provide B cell help. Thus, basophils are important contributors to humoral memory immune responses...
  85. ncbi Cloning and sequencing of the horse and sheep high-affinity IgE receptor alpha chain cDNA
    S M McAleese
    Department of Veterinary Clinical Studies, University of Edinburgh, UK
    Immunogenetics 51:878-81. 2000
  86. pmc Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation
    D Dombrowicz
    Institut National de la Sante et de la Recherche Medicale U167, Institut Pasteur de Lille, 59019 Lille, France
    J Exp Med 193:25-34. 2001
    ....
  87. ncbi Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail
    Z Kibar
    Department of Biochemistry, McGill University, Montreal, Canada
    Nat Genet 28:251-5. 2001
    ..The 0.6-cM/0.7-megabase (Mb) Lp interval is delineated proximally by D1Mit113/Apoa2/Fcer1g and distally by Fcer1a/D1Mit149/Spna1 and contains a minimum of 17 transcription units...
  88. ncbi IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
    The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcepsilonRI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2...
  89. ncbi FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells
    Maria Ekoff
    Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet, KS L2 04 Stockholm, Sweden
    J Immunol 178:4177-83. 2007
    ..mediators and to undergo activation-induced survival upon cross-linking of the high-affinity IgE-receptor (FcepsilonRI)...
  90. ncbi Fine mapping of the human pentraxin gene region on chromosome 1q23
    M T Walsh
    Department of Genetics and Biotechnology Institute, University of Dublin, Trinity College, Dublin, Ireland
    Immunogenetics 44:62-9. 1996
    ..This four-YAC contig includes other genes with immune functions including the FCER1A gene, which encodes the alpha-subunit of the IgE high-affinity Fc receptor and the IFI-16 gene, an interferon-..
  91. ncbi Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1
    S F Kingsmore
    Department of Medicine, University of Florida, Gainesville 32610 0221, USA
    Immunogenetics 42:59-62. 1995
    ....
  92. pmc Indirect involvement of allergen-captured mast cells in antigen presentation
    Taku Kambayashi
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Blood 111:1489-96. 2008
    ..To explore how this may occur, we investigated the fate of mast cells stimulated by antigen and found that FcepsilonRI crosslinking enhances mast cell apoptosis...
  93. ncbi High-resolution linkage map in the vicinity of the Lp locus
    A Mullick
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Genomics 26:479-88. 1995
    ..These studies have allowed the delineation of a maximum genetic interval for Lp of 0.5 cM, a size amenable to physical mapping techniques...
  94. ncbi Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23
    P Stanier
    Institute of Obstetrics and Gynaecology, Queen Charlotte s and Chelsea Hospital, London, United Kingdom
    Genomics 26:473-8. 1995
    ....
  95. ncbi Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Mamm Genome 11:633-8. 2000
    ..Consequently, analysis of the Lp interval may provide important tools to understand how the corresponding region of human Chr 1 contributes to disease, in addition to defining a key gene product required for neurulation...
  96. ncbi Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genomics 55:185-93. 1999
    ....
  97. pmc IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10 355 Science Center Dr, San Diego, CA 92121, USA
    Blood 105:3222-9. 2005
    ..In mouse experiments, naive mast cells are attracted to IgE, and IgE-sensitized mast cells are attracted to antigen. Therefore, IgE and antigen are implicated in mast cell accumulation at allergic tissue sites with local high IgE levels...
  98. ncbi The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL
    Alexander Iain Taylor
    Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, Guy s Campus, London, UK
    Immunogenetics 59:323-8. 2007
    ..It can be expressed on the cell surface only in the presence of an accessory molecule, chFcRgamma, through which it acquires signalling potential...
  99. ncbi Nhlh1, a basic helix-loop-helix transcription factor, is very tightly linked to the mouse looptail (Lp) mutation
    A Mullick
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mamm Genome 6:700-4. 1995
    ..These studies suggest that Nhlh1 and Lp are not allelic. Nevertheless, Nhlh1 is the Chr 1 marker most tightly linked to Lp identified to date and can, therefore, be used as an excellent entry probe to clone the Lp region...