Genomes and Genes
Gene Symbol: Fasl
Description: Fas ligand (TNF superfamily, member 6)
Alias: APT1LG1, CD178, CD95-L, CD95L, Fas-L, Faslg, Tnfsf6, Tnlg1a, gld, tumor necrosis factor ligand superfamily member 6, CD95 ligand, Fas antigen ligand, generalized lymphoproliferative disease, tumor necrosis factor ligand 1a
Publications123 found, 100 shown here
- The Fas death factorS Nagata
Osaka Bioscience Institute, Japan
Science 267:1449-56. 1995Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells...
- NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapyRaquel Gómez-Sintes
Centro de Biologia Molecular Severo Ochoa CBM SO, CSIC UAM, 28049 Madrid, Spain
J Clin Invest 120:2432-45. 2010..factor of activated T cells c3/4 (NFATc3/4) transcription factors to the nucleus, leading to increased Fas ligand (FasL) levels and Fas activation...
- Fas ligand triggers pulmonary silicosisV M Borges
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21944 970, Rio de Janeiro, Brazil
J Exp Med 194:155-64. 2001..Strikingly, Fas ligand-deficient generalized lymphoproliferative disease mutant (gld) mice did not develop silicosis...
- T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosisZhenyue Hao
620 University Ave, Toronto, ON, M5G 2C1, Canada
J Exp Med 199:1355-65. 2004To study the role of Fas-Fas ligand (FasL) interaction-mediated apoptosis in lymphocyte homeostasis, we generated a mutant fas allele allowing conditional inactivation of the fas gene through Cre-mediated recombination...
- Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cellsIris A Camacho
Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
J Immunol 175:90-103. 2005..TCDD triggered the expression of several apoptotic genes, including FasL in AhR wild-type but not AhRKO mice...
- Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allograftsJ Allison
The Walter and Eliza Hall Institute for Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
Proc Natl Acad Sci U S A 94:3943-7. 1997Binding of CD95 (Fas/APO-1) by its ligand (CD95L) commonly induces apoptosis. Apoptosis of activated T cells, induced by CD95L expressed in the rodent testis, has been proposed to be the mechanism of immune privilege [Bellgrau, D...
- Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-induced immunotoxicity: increased resistance of thymocytes from Fas-deficient (lpr) and Fas ligand-defective (gld) mice to TCDD-induced toxicityA B Kamath
Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine
Toxicol Appl Pharmacol 160:141-55. 1999..TCDD treatment caused significant up-regulation in the expression of FasL but not Fas mRNA in the thymocytes of wild-type mice...
- Role of dioxin response element and nuclear factor-kappaB motifs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated regulation of Fas and Fas ligand expressionNarendra P Singh
Department of Pathology, University of South Carolina School of Medicine, Columbia, South Carolina, USA
Mol Pharmacol 71:145-57. 2007We have demonstrated previously that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) up-regulates Fas and FasL in immune cells, although the molecular mechanisms remain unknown...
- Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligandTracy Vargo-Gogola
Department of Cancer Biology, Vanderbilt University, 736 PRB 23rd and Pierce, Nashville, TN 37232 6840, USA
Arch Biochem Biophys 408:155-61. 2002..However, there are contradictory reports that the soluble form of FasL is inactive or anti-apoptotic, resulting in significant controversy in the literature...
- A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ miceJ B Roths
J Exp Med 159:1-20. 1984A newly discovered autosomal recessive mutation, generalized lymphoproliferative disease (gld), in the C3H/HeJ strain of mice, determines the development of early onset massive lymphoid hyperplasia with autoimmunity...
- Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor familyT Suda
Osaka Bioscience Institute, Japan
Cell 75:1169-78. 1993..Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis...
- Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligandT Takahashi
Osaka Bioscience Institute, Japan
Cell 76:969-76. 1994Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and suffer from autoimmune disease...
- Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactionsE A Reap
Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7280, USA
Proc Natl Acad Sci U S A 94:5750-5. 1997..assess whether some of the apoptosis known to occur after ionizing radiation might be mediated by Fas/Fas ligand (FasL) interactions, we quantitated in vitro apoptosis by flow cytometry measurement of DNA content in splenic T and B ..
- Gene transfer of Fas ligand induces tumor regression in vivoH Arai
Howard Hughes Medical Institute, University of Michigan Medical Center, 1150 West Medical Center Drive, 4520 MSRB I, Ann Arbor, MI 48109 0650, USA
Proc Natl Acad Sci U S A 94:13862-7. 1997The Fas-Fas ligand (FasL) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression of immune responses...
- Why do defects in the Fas-Fas ligand system cause autoimmunity?T Suda
Department of Molecular Biology, Osaka Bioscience Institute, Japan
J Allergy Clin Immunol 100:S97-101. 1997..We also have demonstrated that lpr and gld mice, well-known animal models of autoimmune disease are loss-of-function mutants of the Fas and Fas ligand genes, ..
- In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alphaS V Pakala
Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 189:1053-62. 1999..These results argue that islet cells play a TNF-alpha-dependent role in their own demise...
- Perforin is a major contributor to NK cell control of tumor metastasisM J Smyth
Cellular Immunity Laboratory, Austin Research Institute, Heidelberg, Victoria, Australia
J Immunol 162:6658-62. 1999..Fas ligand mutant gld mice displayed uncompromised protection against tumor metastasis...
- Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosisK Kuwano
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
J Clin Invest 104:13-9. 1999..a soluble form of Fas antigen or anti-Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant against the induction of pneumopathy...
- Increased fetal and extramedullary hematopoiesis in Fas-deficient C57BL/6-lpr/lpr miceE Schneider
Universite Rene Descartes Paris V, CNRS UMR 8603, Paris, France
Blood 94:2613-21. 1999..Similar changes occurred in C57BL/6-gld/gld mice, indicating that they resulted from Fas/FasL interactions. Medullary hematopoiesis was not significantly modified in adult mice of either strain...
- Evidence that retinal pigment epithelium functions as an immune-privileged tissueH Wenkel
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 41:3467-73. 2000..This study was undertaken to evaluate whether retinal pigment epithelium (RPE) behaves as an immune-privileged tissue when transplanted extraocularly...
- Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factorJ Wenzel
Institute for Immunology, Christian Albrechts University, Michaelisstrasse 5, 24105 Kiel, Germany
FEBS Lett 509:255-62. 2001..In murine T cells, membrane-bound CD95L (Fas ligand) also acts as a costimulatory receptor to coordinate activation and function in vivo...
- Membrane Fas ligand activates innate immunity and terminates ocular immune privilegeMeredith S Gregory
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
J Immunol 169:2727-35. 2002It has been proposed that the constitutive expression of Fas ligand (FasL) in the eye maintains immune privilege, in part through inducing apoptosis of infiltrating Fas(+) T cells...
- Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld alleleSaoussen Karray
Institut National de la Santé et de la Recherche Médicale Unité 580, Hopital Necker, Paris, France
J Immunol 172:2118-25. 2004..It stands in sharp contrast with the milder disease observed in gld (generalized lymphoproliferative disease) mice, indicating that the FasL allele of these mice encodes a protein still able to bind, albeit ..
- Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune diseaseTamar Aprahamian
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany St, W611, Boston, MA 02118, USA
J Exp Med 199:1121-31. 2004To clarify the link between autoimmune disease and hypercholesterolemia, we created the gld.apoE(-/-) mouse as a model of accelerated atherosclerosis. Atherosclerotic lesion area was significantly increased in gld...
- Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in FaslJian Qiao Zhang
Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
J Exp Med 200:1467-78. 2004Germline mutations in Fas and Fasl induce nonmalignant T cell hyperplasia and systemic autoimmunity and also greatly increase the risk of B cell neoplasms...
- Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivoYing Liu
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
Blood 108:123-33. 2006..A high proportion of splenic early erythroblasts coexpressed the death receptor Fas, and its ligand, FasL. Fas-positive early erythroblasts were significantly more likely to coexpress annexin V than equivalent, Fas-..
- Macrophages inhibit neovascularization in a murine model of age-related macular degenerationRajendra S Apte
Department of Ophthalmology, Washington University School of Medicine, St Louis, Missouri, USA
PLoS Med 3:e310. 2006..The current theory is that macrophage infiltration promotes the development of neovascularization in CNV...
- Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in miceTakahiro Ishikawa
Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
J Virol 83:11777-83. 2009..In this study, we examined the roles of Fas-Fas ligand (FasL) signaling in lethal infection with HSV-2 by using mice with mutated Fas (lpr) or FasL (gld) in C57BL/6 background...
- Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathyDru S Dace
Department of Ophthalmology and Visual Sciences, Washington University in St Louis School of Medicine, St Louis, Missouri, USA
PLoS ONE 4:e7121. 2009....
- Membrane-bound Fas ligand only is essential for Fas-induced apoptosisLorraine A O' Reilly
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Nature 461:659-63. 2009Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity...
- CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory siteElisabeth Letellier
Molecular Neurobiology Unit, German Cancer Research Center, Heidelberg 69120, Germany
Immunity 32:240-52. 2010..Here, we showed that, in rodents and humans, injury to the spinal cord triggered surface expression of CD95 ligand (CD95L, FasL) on peripheral blood myeloid cells...
- Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lprT Giese
Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
J Immunol 149:3097-106. 1992Mice homozygous for lpr and gld develop profound lymphadenopathy characterized by the accumulation of two functionally anergic T cell subsets, a predominant B220+CD4-CD8- double negative (DN) population and a minor, closely related CD4 ..
- Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseP L Cohen
Department of Medicine, University of North Carolina School of Medicine, Chapel Hill 27599 7280
Annu Rev Immunol 9:243-69. 1991The autosomal recessive lpr and gld genes induce in mice multiple autoantibodies and the progressive accumulation of large numbers of non-malignant CD4- CD8- T lymphocytes...
- gld/gld mice are unable to express a functional ligand for FasF Ramsdell
Department of Immunobiology, Immunex Research and Development Corporation, Seattle, WA 98101
Eur J Immunol 24:928-33. 1994Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders...
- Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathwaysB Lowin
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Nature 370:650-2. 1994..Thus, two complementary, specific cytotoxic mechanisms are functional in CTLs, one based on the secretion of lytic proteins and one which depends on cell-surface ligand-receptor interaction...
- Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndromeJ L Chu
Specialized Center of Research in Systemic Lupus Erythematosus, Hospital for Special Surgery Cornell University Medical Center, New York 10021
J Exp Med 181:393-8. 1995..Since the Fas ligand (FasL) has recently been shown to be partly responsible for T cell-mediated cytotoxicity, lymph node cells from lpr and ..
- Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomasT Brunner
Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, California 92037
Nature 373:441-4. 1995..Because T-cell receptor ligation can induce apoptosis in a single T hybridoma cell, we suggest that the Fas/Fas-ligand interaction can induce cell death in a cell-autonomous manner...
- Fas and Fas ligand: lpr and gld mutationsS Nagata
Osaka Bioscience Institute, Japan
Immunol Today 16:39-43. 1995Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis...
- Human Fas ligand: gene structure, chromosomal location and species specificityT Takahashi
Osaka Bioscience Institute, Japan
Int Immunol 6:1567-74. 1994Fas ligand (FasL) is a 40 kDa type II membrane protein belonging to the tumor necrosis factor family, which induces apoptosis by binding to its receptor, Fas. In this report, we isolated the chromosomal gene for human FasL...
- The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene clusterD H Lynch
Department of Immunobiology, Immunex Research and Development Corporation, Seattle, Washington 98101
Immunity 1:131-6. 1994The gene for the mouse Fas ligand was cloned and its chromosomal position determined. Fasl was tightly linked to gld (no crossovers in 567 meiotic events) on mouse chromosome 1 and closely linked with a novel member of the same TNF family ..
- Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnoverL E French
Department of Dermatology, University of Geneva, Medical School, Switzerland
J Cell Biol 133:335-43. 1996The cell surface receptor Fas (FasR, Apo-1, CD95) and its ligand (FasL) are mediators of apoptosis that have been shown to be implicated in the peripheral deletion of autoimmune cells, activation-induced T cell death, and one of the two ..
- Polymorphism of murine Fas ligand that affects the biological activityN Kayagaki
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Proc Natl Acad Sci U S A 94:3914-9. 1997Fas ligand (FasL) is a member of the tumor necrosis factor family and induces apoptosis in Fas (CD95)-bearing target cells...
- Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosisX Zhang
University of California, San Diego, La Jolla, California 92093, USA
J Exp Med 185:1837-49. 1997T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated, activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also observed without restimulation, after a longer lag period...
- Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitisH Waldner
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 159:3100-3. 1997..To determine the roles of Fas and FasL in the involvement of CNS autoimmune injury, we determined susceptibility to EAE of Fas-or FasL-deficient mice...
- Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactionsW F Davidson
Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 187:1825-38. 1998..In this report we investigated the possibility that mutations at the Fas (lpr) and Fasl (gld) loci, which prevent Fas-mediated apoptosis and cause an early onset benign lymphoid hyperplasia and ..
- Fas and Fas ligand interactions suppress melanoma lung metastasisL B Owen-Schaub
Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Exp Med 188:1717-23. 1998..These findings provide the first evidence that Fas-Fas ligand interactions can suppress metastasis and that tumor Fas loss-of-function may be causally linked to metastatic progression...
- Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cellsE Bonfoco
Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Immunity 9:711-20. 1998Fas (CD95) and Fas ligand (FasL) play major roles in staphylococcal enterotoxin B (SEB)-induced peripheral deletion of Vbeta8+ T cells...
- Fas ligand (CD95 ligand) controls angiogenesis beneath the retinaH J Kaplan
Washington University School of Medicine, Department of Ophthalmology and Visual Sciences, St Louis, Missouri 63110, USA
Nat Med 5:292-7. 1999..degeneration demonstrated a pattern of Fas+ new vessels in the center of the vascular complex, surrounded by FasL+ retinal pigment epithelial cells...
- Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitusH T Kreuwel
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 163:4335-41. 1999..The relative contribution of each of the major cytotoxic pathways, perforin/granzyme and Fas/Fas ligand (FasL), in the induction of autoimmune diabetes remains controversial...
- Significant role for Fas in the pathogenesis of autoimmune diabetesX Su
Alexion Pharmaceuticals, New Haven, CT 06511, USA
J Immunol 164:2523-32. 2000..NOD mice bearing the lpr mutation (NOD-lpr/lpr) fail to develop IDDM; 2) transgenic expression of Fas ligand (FasL) on beta cells in NOD mice may result in accelerated IDDM; and 3) irradiated NOD-lpr/lpr mice are resistant to ..
- Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in miceR Nakagawa
Pharmaceutical Research Laboratory, Kirin Brewery Company, Takasaki, Japan
J Immunol 166:6578-84. 2001..Whereas alpha-GalCer did not increase serum alanine aminotransferase activity in B6-lpr/lpr mice and B6-gld/gld mice, it increased the antitumor cytotoxicity of liver MNCS: The alpha-GalCer-induced increase in survival rate ..
- Acute pancreatitis induces FasL gene expression and apoptosis in the liverScott F Gallagher
Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida, USA
J Surg Res 122:201-9. 2004..We previously demonstrated that Kupffer cell-derived cytokines mediate liver injury. In this work, we sought to characterize the role of Fas Ligand (FasL) in liver injury during acute pancreatitis.
- Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expressionKevin L Legge
Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Immunity 23:649-59. 2005..with inoculum dose and is controlled by lymph-node-resident dendritic cells (LNDC) through IL-12p40-regulated FasL-dependent T cell apoptosis...
- Transcriptional regulation of FasL expression and participation of sTNF-alpha in response to sertoli cell injuryPei Li Yao
Institute for Cellular and Molecular Biology, College of Pharmacy, University of Texas, Austin, Texas 78712 1074, USA
J Biol Chem 282:5420-31. 2007The Fas/FasL signaling pathway has previously been demonstrated to be critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl)phthalate (MEHP)-induced Sertoli cell injury...
- ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell deathM Schulte
Biochemical Institute, Christian Albrecht University, Kiel, Germany
Cell Death Differ 14:1040-9. 2007The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity...
- Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunityPeter B Stranges
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Immunity 26:629-41. 2007..Thus, Fas-dependent elimination of APCs is a major regulatory mechanism curbing autoimmune responses and acts in concert with Fas-mediated regulation of chronically activated autoimmune T cells...
- CTLs contain and use intracellular stores of FasL distinct from cytolytic granulesJin Shu He
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
J Immunol 179:2339-48. 2007CTL lyse target cells through the release of cytolytic granule contents and cell surface expression of Fas ligand (FasL)...
- Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gammaYingyu Zhang
Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
J Immunol 181:190-6. 2008..activation-induced cell death (AICD), a common mechanism for elimination of activated T cells, required the Fas and FasL interaction: Fas was stably expressed, while FasL was up-regulated upon TCR reactivation of Th17 cells; Ab ligation ..
- Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosisKentaro Akiyama
Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
Cell Stem Cell 10:544-55. 2012..Here we show that in mice systemic infusion of BMMSCs induced transient T cell apoptosis via the FAS ligand (FASL)-dependent FAS pathway and could ameliorate disease phenotypes in fibrillin-1 mutated systemic sclerosis (SS) and ..
- Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in miceH Tsutsui
Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan
Immunity 11:359-67. 1999..Here, we investigated caspase-1-independent processing of IL-18 in Fas ligand (FasL)-stimulated macrophages and its involvement in liver injury. Administration of Propionibacterium acnes (P...
- Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptusJ S Hunt
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
J Immunol 158:4122-8. 1997..To evaluate the postulate that cell traffic is restricted by expression of Fas ligand (FasL) in the uterus and placenta, FasL mRNA was identified by using reverse transcription-PCR, and FasL protein was ..
- Immunologic abnormalities of mice bearing the gld mutation suggest a common pathway for murine nonmalignant lymphoproliferative disorders with autoimmunityW F Davidson
Proc Natl Acad Sci U S A 82:1219-23. 1985Mice bearing the autosomal recessive mutation gld have been shown to develop massive lymphadenopathy, hypergammaglobulinemia, and autoantibodies and to die prematurely with interstitial pneumonitis...
- Characterization of the non-functional Fas ligand of gld miceM Hahne
Institute of Biochemistry, University of Lausanne, Switzerland
Int Immunol 7:1381-6. 1995..The lpr mutation is characterized by the absence of functional Fas, whereas gld mice exhibit an inactive FasL due to a point mutation proximal to the extracellular C-terminus...
- Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disordersD Watanabe
Osaka Bioscience Institute, Japan
EMBO J 14:12-8. 1995Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and splenomegaly and suffer from autoimmune disease...
- Phenotypic abnormalities of splenic and bone marrow B cells in lpr and gld miceE A Reap
Department of Medicine, University of North Carolina, Chapel Hill, 27599 7280, USA
Clin Immunol Immunopathol 78:21-9. 1996..B cells from gld mice showed the same phenotypic abnormalities as those from lpr...
- Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld miceU Malipiero
Department of Neurosurgery, University Hospital Zurich, Switzerland
Eur J Immunol 27:3151-60. 1997The expression and action of Fas/Fas ligand (FasL) in multiple sclerosis has been postulated as a major pathway leading to inflammatory demyelination...
- Allele-specific PCR analysis for detection of the gld Fas-ligand point mutationR M Hoek
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
J Immunol Methods 210:109-12. 1997..of a naturally occurring missense point mutation in the gene encoding Fas-ligand (FasL/CD95L) in generalized lymphoproliferative disease (gld) mice has lead to the characterization of FasL as an important mediator of apoptosis...
- Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr miceJ K Booker
Department of Medicine, University of North Carolina, Chapel Hill 27599 7280, USA
J Immunol 161:4536-41. 1998..This study demonstrates that lpr mice can produce functional Fas protein. This system is also appropriate for identifying the in vivo role of Fas/FasL in apoptosis following other cell manipulations.
- Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibodyB Zhu
Department of Microbiology, Boston University School of Medicine, MA 02118, USA
Eur J Immunol 30:1778-84. 2000..However, reconstitution with double Fas-/Fas ligand (FasL)-deficient stem cells does not result in wasting disease, demonstrating that FasL expression is an important ..
- Fas ligand-deficient mice display enhanced leukocyte infiltration and intima hyperplasia in flow-restricted vesselsM Sata
Division of Cardiovascular Research, Tufts University School of Medicine, Boston, MA 02135, USA
J Mol Cell Cardiol 32:1395-400. 2000Fas ligand (FasL) is a death factor that induces apoptosis in Fas-bearing cells...
- 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injuryAaron M Fullerton
Department of Pharmacology and Toxicology, Center for Integrative Toxicology, Michigan State University, 1129 Farm Lane, Room 215, East Lansing, MI 48824, USA
Toxicol Appl Pharmacol 266:317-27. 2013..increased the proportion of activated natural killer T (NKT) cells and the percent of cells expressing Fas ligand (FasL) after Con A administration...
- Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand geneE S Sobel
Department of Medicine, University of North Carolina, Chapel Hill 27599 7280
Int Immunol 5:1275-8. 1993lpr and gld mice develop phenotypically indistinguishable systemic autoimmune diseases and marked lymphadenopathy dominated by CD4-CD8- T cells...
- Fas system-mediated apoptosis suppresses lymphopoiesisK Yasutomo
Department of Pediatrics, Univerity of Tokushima, Japan
J Immunol 157:1981-6. 1996..a fetal thymus (FT) plus fetal liver cells (FLC) from MRL-lpr/lpr mice (Fas Ag-defective mice), or with FT from C3H-gld/gld mice (Fas ligand-defective mice) plus FLC from C3H +/+ mice, developed FLC-derived T and B cells...
- Apoptosis and the thymic microenvironment in murine lupusY Takeoka
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, School of Medicine, Davis, California 95616, USA
J Autoimmun 13:325-34. 1999..We studied NZB, MRL/lpr, BXSB/Yaa, C3H/gld mice and BALB/c and C57BL/6 as control mice...
- Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liverHannes A Rudiger
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
Gastroenterology 122:202-10. 2002..Apoptosis of hepatocytes is a central feature of ischemic injury in the liver. The aim of this study was to identify extracellular inducers of apoptosis in the murine ischemic liver...
- Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligandMichele M Kosiewicz
Department of Microbiology and Immunology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
Int Immunol 16:697-706. 2004..On the other hand, our data showed that the Fas-Fas ligand (FasL) pathway was involved in this form of tolerance since TGF-beta-treated APC could not mediate tolerance in primed ..
- Prolonged production of TNF-alpha exacerbates illness during respiratory syncytial virus infectionJohn A Rutigliano
Vaccine Research Center National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 173:3408-17. 2004..Preliminary experiments in gld mice that express nonfunctional Fas ligand (FasL) revealed that RSV-induced illness is significantly reduced in the absence of FasL-mediated killing...
- Fas ligand but not complement is critical for control of experimental Staphylococcus aureus EndophthalmitisMichael Engelbert
Departments of Microbiology and Immunology, and Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Invest Ophthalmol Vis Sci 46:2479-86. 2005To determine the role of complement and Fas Ligand (FasL) in the host defense against Staphylococcus aureus endophthalmitis.
- Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus modelTamar Aprahamian
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 177:3028-34. 2006..In this study, we analyzed the effect of the HMG-CoA reductase inhibitor simvastatin on disease manifestations in gld.apoE-/- mice that lack functional Fas ligand and apolipoprotein E and exhibit accelerated atherosclerosis and ..
- Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activityRobert Zeiser
Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Blood 110:4588-98. 2007....
- Thy1 up-regulates FasL expression in lung myofibroblasts via Src family kinasesPazit Y Cohen
Head, Institute for Pulmonary Medicine, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel
Am J Respir Cell Mol Biol 40:231-8. 2009We have previously demonstrated that myofibroblasts from lungs with bleomycin-induced fibrosis overexpress FasL molecules...
- A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouseA Matsuzawa
Laboratory Animal Research Center, University of Tokyo, Japan
J Exp Med 171:519-31. 1990..The results supported the control of lymphadenopathy by a single autosomal recessive gene. Since C3H/He-gld/gld (C3H-gld), MRL/MpJ-lpr/lpr (MRL-lpr), and C3H/HeJ-lpr/lpr (C3H-lpr) mice develop the same type of lymphoid ..
- Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotypeA Matsuzawa
Laboratory Animal Research Center, University of Tokyo, Japan
Eur J Immunol 24:1714-6. 1994Mice homozygous for the lpr (lymphoproliferation), lprcg or gld (generalized lymphoproliferative disease) mutation develop strikingly similar lymphadenopathy with expansion of B220+ CD4- CD8- double-negative (DN) T cells and autoimmunity...
- gld and lpr hematopoietic cell transfers: common and different serological features of the C57BL/6 chimerasD Velin
Laboratoire d Immunologie, Universite de Strasbourg, Illkirch, France
Cell Immunol 148:331-45. 1993Homozygosity for either the lpr (lymphoproliferation) or the gld (generalized lymphoproliferative disease) mutation in mice causes the development of strikingly similar hyperglobulinemia and lymphoproliferative syndromes...
- Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defectR Ettinger
Department of Microbiology, Boston University School of Medicine, MA 02118
J Immunol 152:1557-68. 1994Homozygosity for either of the autosomal recessive mutations, lpr or gld, confers an autoimmune syndrome characterized by massive lymphoid hyperplasia and extensive autoantibody production...
- The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld miceR A Eisenberg
Department of Medicine, University of North Carolina at Chapel Hill 27599 7280
Semin Immunol 6:49-54. 1994B cell abnormalities play a central role in the systemic autoimmune syndromes of lpr and gld mice...
- Regulation of T-cell death genes: selective inhibition of FasL- but not Fas-mediated functionH Cui
Arthritis Center, Boston University School of Medicine, Massachusetts, USA
Cell Immunol 167:276-84. 1996Activation-induced cell death (AICD) requires coexpression of Fas and FasL. Hybridoma T-cells express detectable FasL mRNA 3 to 5 hr after culture in anti-CD3-coated wells...
- Enhancement of ectopic bone formation in mice with a deficit in Fas-mediated apoptosisS Mori
Second Department of Oral and Maxillofacial Surgery, Tohoku University School of Dentistry, Sendai, Japan
Pathol Int 47:112-6. 1997..in a C3H/HeJ strain of mice bearing a mutant gene, the lymphoproliferation gene (lpr) or the generalized lymphoproliferative disease gene (gld), both of which are known to be a Fas deletion mutant and a Fas ligand mutant, ..
- Apoptosis in adult mouse testis induced by experimental cryptorchidismY Ohta
Department of Veterinary Science, Faculty of Agriculture, Tottori University, Japan
Acta Anat (Basel) 157:195-204. 1996..In lpr(cg) and lpr mice lacking functional Fas, gld mice lacking functional Fas ligand and lpr(cg)-gld mice lacking both functional Fas and Fas ligand, the ..
- Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cellsA J Urtreger
Research Area, Institute of Oncology Angel H Roffo, University of Buenos Aires, Buenos Aires, Argentina
Int J Cancer 82:748-53. 1999..These results strongly suggest a novel activity for the multifunctional glycoprotein FN regarding the regulation of uPA production as well as the capacity of tumor cells to bind uPA...
- Cytokine deprivation of naive CD8+ T cells promotes minimal cell cycling but maximal cytokine synthesis and autonomous proliferation subsequently: a mechanism of self-regulationS Sad
Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
J Immunol 163:2443-51. 1999..of cytokine synthesis was not due to increased cytotoxicity, as inhibition occurred even in the absence of perforin/FasL. Interestingly, CD8+ effectors secreting reduced amounts of cytokines exhibited enhanced IL-2Ralpha, but reduced IL-..
- Fas ligand-deficient gld mice are more susceptible to graft-versus-host-diseaseM R van den Brink
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Transplantation 70:184-91. 2000The Fas/Fas ligand (FasL) pathway plays an important role in a number of apoptotic processes that could be important for the development of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT), such as cytolysis of ..
- Interferon-gamma is required for innate immunity to Cryptosporidium parvum in miceA R Hayward
Departments of Immunology and Pediatrics and the Barbara Davis Childhood Diabetes Center, University of Colorado School of Medicine, Denver, CO 80262, USA
J Infect Dis 182:1001-4. 2000..The results indicate that mice unable to produce specific immune responses because of the SCID mutation require IFN-gamma to avoid death after infection with CP...
- Pathogenesis of herpes simplex virus type 1-induced corneal inflammation in perforin-deficient miceE Chang
Department of Molecular Microbiology Immunology, School of Medicine, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA
J Virol 74:11832-40. 2000..There was no significant difference between the infectious viral titers isolated from the eyes of PKO and wild-type mice. Our findings show that perforin is important in the pathogenesis of HSK...
- CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosisJ Turner
Mycobacterial Research Laboratories, Colorado State University, 200 W Lake, Fort Collins, CO 80523, USA
Am J Respir Cell Mol Biol 24:203-9. 2001..the cytolytic mechanisms, mice with targeted disruptions for CD8 and perforin or with gene mutations in the CD95/ CD95L signaling pathway were exposed to pulmonary infection...
- Modulation of fas/fasL in a murine retroviral infection by AZT and methionine enkephalinR Bowden
University of South Florida College of Medicine, Department of Medical Microbiology and Immunology, Tampa 33612, USA
Adv Exp Med Biol 493:143-52. 2001
- Porcine Fas-ligand gene: genomic sequence analysis and comparison with human geneYukari Motegi-Ishiyama
Department of Anesthesiology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara shi 228 8555, Japan
Mol Immunol 38:581-6. 2002Thymic Fas-ligand (FasL) cDNA and hepatic FasL genomic sequences were obtained from a 2-month-old LW pig. From these nucleotide sequences, amino acid sequence was deduced and compared with FasL sequences obtained from various animals...
- The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD miceN Petrovsky
Autoimmunity Research Unit, Canberra Clinical School, University of Sydney, Canberra ACT 2606, Australia
Ann N Y Acad Sci 958:204-8. 2002Fas ligand (FasL), a type 2 membrane protein belonging to the TNF family, plays an important role in the induction of cell death. Ligation of Fas receptors by FasL results in apoptosis of the Fas-expressing cell...
- Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2Jon M Wigginton
Pediatric Oncology Branch, National Cancer Institute Center for Cancer Research, Building 560, Room 31 93, Bethesda, MD 20892, USA
J Immunol 169:4467-74. 2002....
- Mechanisms of accelerated immune-mediated diabetes resulting from islet beta cell expression of a Fas ligand transgeneDiego G Silva
Autoimmunity Research Unit, The Canberra Hospital, Medical School, Australian National University, Medical Informatics Center, University of Canberra, and The John Curtin School of Medical Research, Canberra, Australia
J Immunol 170:4996-5002. 2003Nonobese diabetic (NOD) mice transgenic for Fas ligand (FasL) on islet beta cells (HIPFasL mice) exhibit an accelerated diabetes distinct from the normal autoimmune diabetes of NOD mice...
- Fas ligand on tumor cells mediates inactivation of neutrophilsYi Ling Chen
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
J Immunol 171:1183-91. 2003The expression of Fas ligand (FasL) on tumor cells (tumor FasL) has been implicated in their evasion of immune surveillance...
- IMMUNOMODULATORY STRATEGIES IN AUTOIMMUNE GASTRITISMICHELE KOSIEWICZ; Fiscal Year: 2002..The goal of the third specific aim is to explore the ability of FasL-expressing APCs to treat autoimmune disease either independently or as a supplement to treatment with TGFbeta-..
- Thymic Influence on Ocular ImmunoregulationRobert E Cone; Fiscal Year: 2010....
- T reg Cells in MyocarditisSally A Huber; Fiscal Year: 2010..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
- Analyzing and modulating immunoregulatory defects in autoimmune disease.Michele M Kosiewicz; Fiscal Year: 2010..abstract_text> ..
- STUDIES OF LUNG DISEASES OF HIV TRANSGENIC MICEPaul Jolicoeur; Fiscal Year: 2009..This research is especially relevant to public health, especially children with AIDS, developing lung diseases at high frequency. ..
- Sex in MyocarditisSally Huber; Fiscal Year: 2008..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
- HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTSPravin Singhal; Fiscal Year: 2007..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..
- The regulation of tumor immunity by NKT cellsMark Smyth; Fiscal Year: 2007..This proposal focuses clearly on a pivotal immune control mechanism that will influence many current and future immunotherapies. ..
- Akt activation sustains silica induced inflammationCELINE BEAMER; Fiscal Year: 2006..abstract_text> ..
- CDI and Gamma Delta+ in Viral MyocarditisSally Huber; Fiscal Year: 2005..abstract_text> ..
- Sex-based differences in regulatory T cell responsesMICHELE KOSIEWICZ; Fiscal Year: 2004..The results of these studies will provide important information that can lead to the development of novel therapies for the prevention and treatment of autoimmune disease. ..
- CD40-CD154 Interactions in Cryptosporidial ImmunityESTHER PONNURAJ; Fiscal Year: 2004..The results will be important for immunodeficient humans chronically infected with the parasite. ..
- Requirements for regulatory T cell developmentMICHELE KOSIEWICZ; Fiscal Year: 2003..These experiments may determine the requirements for regulatory T cell development, and thereby, identify pathways that can be therapeutically manipulated to prevent and/or treat autoimmune diseases. ..
- CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATIONROBERT CONE; Fiscal Year: 2003..Understanding of this axis could impact on the management o f inflammatory eye disease, organ transplants (e.g. cornea), ocular tumors and autoimmune disease. ..
- CARDIAC LESIONS IN HIV1 TRANSGENIC MICEPaul Jolicoeur; Fiscal Year: 2001..End of Abstract) ..
- Combinatorial Protein Transfer for Cancer TherapeuticsAoshuang Chen; Fiscal Year: 2006..abstract_text> ..
- Sex in Viral MyocarditisSally Huber; Fiscal Year: 2004..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
- CHEMOKINES IN LUNG DISEASE OF HIV1 TRANSGENIC MICEPaul Jolicoeur; Fiscal Year: 2003..4- To determine whether blocking or deleting specific chemokines or their receptors and overexpressing some chemokine receptors alter the development of lymphocytic interstitial pneumonitis. ..
- Ocular Regulation of AutoimmunityROBERT CONE; Fiscal Year: 2009..The results of this study could aid our understanding of the systemic basis for the ocular regulation of autoimmunity and develop procedures for the modulation of active autoimmune disease. ..
- CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSISSally Huber; Fiscal Year: 2002..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
- PROTEIN PROFILING OF ORAL MUCOSA OF HIV TRANSGENIC MICEPaul Jolicoeur; Fiscal Year: 2010..This research is especially relevant to public health in view of the high frequency of oral complications (especially candidiasis) in HIV-1 infected individuals. ..