Fas

Summary

Gene Symbol: Fas
Description: Fas (TNF receptor superfamily member 6)
Alias: AI196731, APO1, APT1, CD95, TNFR6, Tnfrsf6, lpr, tumor necrosis factor receptor superfamily member 6, FASLG receptor, Fas (TNF receptor superfamily member), Fas antigen, apo-1 antigen, apoptosis-mediating surface antigen FAS, lymphoproliferation
Species: mouse

Top Publications

  1. ncbi The Fas death factor
    S Nagata
    Osaka Bioscience Institute, Japan
    Science 267:1449-56. 1995
  2. pmc Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
  3. pmc Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
    B S Andrews
    J Exp Med 148:1198-215. 1978
  4. ncbi Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    T Takahashi
    Osaka Bioscience Institute, Japan
    Cell 76:969-76. 1994
  5. pmc Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
    Lorraine A O' Reilly
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 461:659-63. 2009
  6. ncbi Fas and Fas ligand: lpr and gld mutations
    S Nagata
    Osaka Bioscience Institute, Japan
    Immunol Today 16:39-43. 1995
  7. pmc Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
    Ying Liu
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 108:123-33. 2006
  8. ncbi Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations
    Cedric Raoul
    INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Neuron 35:1067-83. 2002
  9. pmc Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy
    Dru S Dace
    Department of Ophthalmology and Visual Sciences, Washington University in St Louis School of Medicine, St Louis, Missouri, USA
    PLoS ONE 4:e7121. 2009
  10. doi CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site
    Elisabeth Letellier
    Molecular Neurobiology Unit, German Cancer Research Center, Heidelberg 69120, Germany
    Immunity 32:240-52. 2010

Research Grants

  1. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
  2. Roles of MIF and iNOS in SLE-associate inflammation
    Michael Hickey; Fiscal Year: 2007
  3. BRAIN CELL DEATH IN MRL MICE: TARGETS AND MECHANISMS
    Boris Sakic; Fiscal Year: 2004
  4. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2007
  5. CD40-CD154 Interactions in Cryptosporidial Immunity
    ESTHER PONNURAJ; Fiscal Year: 2004
  6. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
  7. B CELL REPERTOIRE FORMATION
    ANN FEENEY; Fiscal Year: 2009
  8. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
  9. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
  10. Impact of Fli-1 expression on lupus disease development
    Xian Zhang; Fiscal Year: 2007

Detail Information

Publications217 found, 100 shown here

  1. ncbi The Fas death factor
    S Nagata
    Osaka Bioscience Institute, Japan
    Science 267:1449-56. 1995
    b>Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells...
  2. pmc Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
    ..We examined mice lacking the gene encoding Bim (Bcl2l11) and with the inactivating lpr mutation in the gene encoding Fas (Fas), designated Bcl2l11(-/-)Fas(lpr/lpr) mice...
  3. pmc Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
    B S Andrews
    J Exp Med 148:1198-215. 1978
    ....
  4. ncbi Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    T Takahashi
    Osaka Bioscience Institute, Japan
    Cell 76:969-76. 1994
    Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and suffer from autoimmune disease...
  5. pmc Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
    Lorraine A O' Reilly
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 461:659-63. 2009
    b>Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity...
  6. ncbi Fas and Fas ligand: lpr and gld mutations
    S Nagata
    Osaka Bioscience Institute, Japan
    Immunol Today 16:39-43. 1995
    b>Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis...
  7. pmc Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
    Ying Liu
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 108:123-33. 2006
    ..A high proportion of splenic early erythroblasts coexpressed the death receptor Fas, and its ligand, FasL...
  8. ncbi Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations
    Cedric Raoul
    INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Neuron 35:1067-83. 2002
    ..We show that Fas-triggered death of normal embryonic motoneurons requires transcriptional upregulation of neuronal NOS and involves ..
  9. pmc Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy
    Dru S Dace
    Department of Ophthalmology and Visual Sciences, Washington University in St Louis School of Medicine, St Louis, Missouri, USA
    PLoS ONE 4:e7121. 2009
    ....
  10. doi CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site
    Elisabeth Letellier
    Molecular Neurobiology Unit, German Cancer Research Center, Heidelberg 69120, Germany
    Immunity 32:240-52. 2010
    ..Here, we showed that, in rodents and humans, injury to the spinal cord triggered surface expression of CD95 ligand (CD95L, FasL) on peripheral blood myeloid cells...
  11. pmc The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo
    Megan S Ford
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 196:261-7. 2002
    Lymphoproliferative (lpr) mice, which lack functional Fas receptor expression and develop autoimmune lymphoproliferative disease, have an accumulation of T cell receptor-alphabeta(+)CD4(-)CD8(-) (double negative T cells [DNTC]) in the ..
  12. pmc T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis
    Zhenyue Hao
    620 University Ave, Toronto, ON, M5G 2C1, Canada
    J Exp Med 199:1355-65. 2004
    To study the role of Fas-Fas ligand (FasL) interaction-mediated apoptosis in lymphocyte homeostasis, we generated a mutant fas allele allowing conditional inactivation of the fas gene through Cre-mediated recombination...
  13. ncbi Interferon-beta: a therapeutic for autoimmune lupus in MRL-Faslpr mice
    Andreas Schwarting
    First Department of Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz 55131, Germany
    J Am Soc Nephrol 16:3264-72. 2005
    ..For determining whether IFN-beta treatment is harmful or beneficial in lupus, MRL-Fas(lpr) mice were injected with this type I IFN...
  14. ncbi Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
    B Lowin
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nature 370:650-2. 1994
    ..b>Fas is an apoptosis-signalling receptor molecule on the surface of a number of different cells...
  15. ncbi Lpr and MRL background gene involvement in the control of adjuvant enhanced arthritis in MRL-lpr mice
    L G Ratkay
    Department of Oral Biology, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    J Autoimmun 7:561-73. 1994
    The MRL-lpr mouse strain develops a mild spontaneous arthritis which can be enhanced by the intradermal injection of complete Freund's adjuvant (CFA)...
  16. pmc Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene
    J Wu
    University of Alabama, Birmingham
    J Exp Med 178:461-8. 1993
    The MRL-lpr/lpr mouse strain is a model of systemic autoimmune disease. In this model, intrinsic defects of intrathymic T cell development include defective deletion of self-reactive T cells and expression of endogenous retroviruses...
  17. pmc Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice
    A M Jevnikar
    Robarts Research Institute, University of Western Ontario, London, Canada
    J Exp Med 179:1137-43. 1994
    MRL-lpr mice develop aggressive autoimmune kidney disease associated with increased or de novo renal expression of major histocompatibility complex (MHC) class II molecules and a massive systemic expansion of CD4-CD- double negative (DN) ..
  18. pmc FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen
    K G Smith
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 92:11628-32. 1995
    ..To address the role of the apoptosis-signaling cell surface molecule FAS in the B-cell response to antigen, we have examined the T-cell-dependent B-cell response to the carrier-conjugated ..
  19. ncbi The role of Fas in autoimmune diabetes
    A V Chervonsky
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell 89:17-24. 1997
    ..Fas-negative NOD(lpr/lpr) animals were resistant to diabetogenic T cells and to spontaneous diabetes...
  20. ncbi Fas engagement accelerates liver regeneration after partial hepatectomy
    J Desbarats
    Department of Medicine, University of Vermont, Burlington, Vermont 05401, USA
    Nat Med 6:920-3. 2000
    Fas (CD95) is a receptor involved in induction of apoptotic cell death of Fas-bearing cells, including hepatocytes and T cells. Injection of Fas-specific antibodies into mice leads to fulminant hepatic failure and death...
  21. pmc Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 202:321-31. 2005
    ..These results demonstrate a specific requirement for TLR9 in autoantibody formation in vivo and indicate a critical role for innate immune activation in autoimmunity...
  22. doi Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses
    Ramanjaneyulu Allam
    Medical Policlinic, University of Munich, Germany
    Eur J Immunol 38:3487-98. 2008
    ..By contrast, transient exposure to non-CpG DNA exacerbate lupus nephritis in association with splenomegaly, lymphoproliferation, hypergammaglobulinaemia and increased B220(+)CD138(+) plasma cells...
  23. pmc Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions
    E A Reap
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7280, USA
    Proc Natl Acad Sci U S A 94:5750-5. 1997
    ..This defect blocks apoptotic deletion of autoreactive T and B cells, leading to lymphoproliferation and lupus-like autoantibody production...
  24. pmc Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice
    M Adachi
    Osaka Bioscience Institute, Japan
    Proc Natl Acad Sci U S A 90:1756-60. 1993
    The mouse lpr (lymphoproliferation) mutation carries a rearrangement in the chromosomal gene for the Fas antigen, which mediates apoptosis...
  25. ncbi Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone mice
    G J Prud'homme
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Immunol 32:495-503. 1995
    ..The results reveal considerable overexpression of IL-1 beta, IL-10 and IFN gamma transcripts in SLE-prone MRL-lpr/lpr (MRL/l) and BXSB male (BXSBm) mice, but with some strain differences...
  26. pmc Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover
    L E French
    Department of Dermatology, University of Geneva, Medical School, Switzerland
    J Cell Biol 133:335-43. 1996
    The cell surface receptor Fas (FasR, Apo-1, CD95) and its ligand (FasL) are mediators of apoptosis that have been shown to be implicated in the peripheral deletion of autoimmune cells, activation-induced T cell death, and one of the two ..
  27. pmc RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    Christina M Lau
    Department of Microbiology, Boston University School of Medicine, MA 02118, USA
    J Exp Med 202:1171-7. 2005
    ..As further evidence that TLRs play a key role in autoantibody responses in SLE, we found that autoimmune-prone mice, lacking the TLR adaptor protein MyD88, had markedly reduced chromatin, Sm, and rheumatoid factor autoantibody titers...
  28. doi Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction
    Ashley E Weant
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunity 28:218-30. 2008
    ..Mutation of Bim, a proapoptotic protein in the intrinsic death pathway, or Fas, a tumor necrosis factor receptor (TNFR) superfamily member of the extrinsic pathway, results in late-onset ..
  29. ncbi Loss of Fas/Apo-1 receptor accelerates lymphomagenesis in E mu L-MYC transgenic mice but not in animals infected with MoMuLV
    M Zörnig
    Institut für Molekularbiologie und Tumorforschung IMT, Philipps Universitat Marburg, Germany
    Oncogene 10:2397-401. 1995
    The Fas/Apo-1 receptor is an integral membrane protein that transduces apoptotic signals upon binding to its natural ligand or to specific antibodies...
  30. pmc Pathogenesis of autoimmunity in alphabeta T cell-deficient lupus-prone mice
    S L Peng
    Section of Rheumatology, Yale University School of Medicine, New Haven, CT, USA
    Clin Exp Immunol 111:107-16. 1998
    ..lupus lesions, renal and skin disease, in TCR alpha -/- MRL mice that possessed either functional or defective Fas antigen (Fas + or lpr)...
  31. pmc Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice
    T Moroy
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Germany
    Proc Natl Acad Sci U S A 90:10734-8. 1993
    ..of the immunoglobulin heavy chain gene enhancer E mu) into lpr/lpr mice results in strong acceleration of lymphoproliferation and dramatic enlargement of lymph nodes...
  32. ncbi B cell selection and allelic exclusion of an anti-DNA Ig transgene in MRL-lpr/lpr mice
    J H Roark
    Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 154:4444-55. 1995
    ..We have shown that nonautoimmune mice regulate anti-DNA B cells, and that lupus-prone MRL-lpr/lpr mice are defective in this regulation...
  33. ncbi Effects of the lpr mutation on elimination and inactivation of self-reactive B cells
    J C Rathmell
    Program in Immunology, Stanford University School of Medicine, CA 94305
    J Immunol 153:2831-42. 1994
    Mice homozygous for the lymphoproliferation (lpr) mutation, which disrupts expression of the Fas cell surface molecule, develop an autoimmune syndrome with a spectrum of autoantibodies resembling human SLE...
  34. pmc A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis
    K Chu
    Department of Medicine, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 92:11894-8. 1995
    b>Fas, a member of the tumor necrosis factor receptor family, can induce apoptosis when activated by Fas ligand binding or anti-Fas antibody crosslinking...
  35. pmc Arteritis in a novel congenic strain of mice derived from MRL/Lpr lupus mice: genetic dissociation from glomerulonephritis and limited autoantibody production
    M Nose
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Am J Pathol 149:1763-9. 1996
    An MRL/Mp strain of mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop systemic vasculitis and glomerulone phritis in the same individual, and both have been thought to be associated with an increase in ..
  36. ncbi Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis
    H Waldner
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:3100-3. 1997
    ..To determine the roles of Fas and FasL in the involvement of CNS autoimmune injury, we determined susceptibility to EAE of Fas-or FasL-deficient ..
  37. ncbi Timing and casting for actors of thymic negative selection
    N Dautigny
    Institut National de la Sante et de la Recherche Medicale, Unit 345, Institut Necker, Paris, France
    J Immunol 162:1294-302. 1999
    ..Surprisingly, we found that thymic negative selection was impaired in the absence of Fas, but not FasL, molecule expression...
  38. ncbi Severe impairment of B cell function in lpr/lpr mice expressing transgenic Fas selectively on B cells
    H Komano
    Department of Immunology, Mitsubishi Kasei Institute of Life Sciences, Machida, Japan
    Int Immunol 11:1035-42. 1999
    Transgenic lpr/lpr mice expressing functional Fas selectively on B cells were produced in an attempt to elucidate the role of Fas on B cells in the regulation of autoantibody production...
  39. pmc Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern
    Yijin Li
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Exp Med 196:1543-52. 2002
    ..Here, we studied the influence of autoimmunity on expression and regulation of 3H9H/56R. In 3H9H/56R MRL/lpr mice, the expression of anti-dsDNA is vastly accelerated...
  40. ncbi Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Shawn Hayley
    Ottawa Health Research Institute, Neuroscience Group, Ottawa, Ontario, Canada K1H 8M5
    J Neurosci 24:2045-53. 2004
    ..In this respect, Fas, a member of the tumor necrosis factor receptor family with proapoptotic and inflammatory functions, was reported ..
  41. ncbi Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice
    Lisa C Watson
    The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 177:1120-8. 2006
    ..We analyzed 518 sequences from adult MRL/lpr- and C57BL/6 TdT-deficient B cell precursors and found only two examples of CDR3 with D-D rearrangements and one ..
  42. pmc IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice
    Andrew L Rankin
    Inflammation and Immunology, Pfizer Research, Cambridge, MA 02140, USA
    J Immunol 188:1656-67. 2012
    MRL/MpJ-Fas(lpr/lpr)/J (MRL(lpr)) mice develop lupus-like disease manifestations in an IL-21-dependent manner...
  43. ncbi Expression and function of the murine CD95/FasR/APO-1 receptor in relation to B cell ontogeny
    K B Onel
    Specialized Center of Research SCOR in SLE, Hospital for Special Surgery Cornell University Medical Center, New York, NY 10021, USA
    Eur J Immunol 25:2940-7. 1995
    Mice defective in Fas-mediated apoptosis (lpr phenotype) have an intrinsic B cell abnormality that predisposes them to autoantibody production...
  44. pmc Association of lpr gene with graft-vs.-host disease-like syndrome
    A N Theofilopoulos
    J Exp Med 162:1-18. 1985
    ..between two lines of mice (MRL lpr/lpr and MRL +/+) that are congenic, differing only at the lpr (lymphoproliferation) and possibly closely linked genes...
  45. ncbi Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin
    P F Mixter
    Department of Medicine, University of Vermont College of Medicine, Burlington 05405
    J Immunol 154:2063-74. 1995
    The CD4-CD8- T cells that accumulate in lpr/lpr mice have previously expressed CD8, on the basis of studies of CD8 alpha gene demethylation...
  46. ncbi beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice
    G J Christianson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 156:4932-9. 1996
    MRL-lpr/lpr mice develop a distinctive immunologic disease characterized by accumulation of unusually large numbers of T cells in the peripheral lymphoid organs...
  47. pmc A role for Fas in negative selection of thymocytes in vivo
    H Kishimoto
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Exp Med 187:1427-38. 1998
    To seek information on the role of Fas in negative selection, we examined subsets of thymocytes from normal neonatal mice versus Fas-deficient lpr/lpr mice injected with graded doses of antigen...
  48. pmc Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice
    Takahiro Ishikawa
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Virol 83:11777-83. 2009
    ..the roles of Fas-Fas ligand (FasL) signaling in lethal infection with HSV-2 by using mice with mutated Fas (lpr) or FasL (gld) in C57BL/6 background...
  49. pmc The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn
    J L Chu
    Hospital for Special Surgery, Cornell University Medical Center, New York, New York 10021
    J Exp Med 178:723-30. 1993
    ..A mutation in the Fas gene in MRL/lpr mice results in massive lymphoproliferation (lpr) and accelerated autoimmunity...
  50. ncbi IL-10 regulates murine lupus
    Zhinan Yin
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 169:2148-55. 2002
    MRL/MpJ-Tnfrsf6(lpr) (MRL/MpJ-Fas(lpr); MRL-Fas(lpr)) mice develop a spontaneous lupus syndrome closely resembling human systemic lupus erythematosus...
  51. pmc Contribution of Fas to diabetes development
    Alexei Y Savinov
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 100:628-32. 2003
    Fas (Tnfrsf6, Apo-1, CD95) is a death receptor involved in apoptosis induced in many cell types. Fas have been shown to be expressed by insulin-producing beta cells in mice and humans...
  52. pmc T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells
    Robin A Herlands
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Immunity 29:249-60. 2008
    On the lupus-prone MRL-lpr/lpr (MRL-lpr) background, AM14 rheumatoid factor (RF) B cells are activated, differentiate into plasmablasts, and undergo somatic hypermutation outside of follicles...
  53. pmc Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis
    K Kuwano
    Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    J Clin Invest 104:13-9. 1999
    ..Here we demonstrated that the administration of a soluble form of Fas antigen or anti-Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant ..
  54. pmc Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene
    D Wofsy
    J Exp Med 154:1671-80. 1981
    ..Congenic MRL-+/+ and B6-+/+ mice, which lack the lpr gene responsible for accelerated autoimmunity and lymphoproliferation, have normal IL-2 activity...
  55. ncbi The accumulation of B220+ CD4- CD8- (DN) T cells in C3H-lpr/lpr mice is not accelerated by the stimulation of CD8+ T cells or B220+ DN T cells with staphylococcal enterotoxin B and occurs independently of V beta 8+ T cells
    T Giese
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int Immunol 7:1213-23. 1995
    ..the accumulation of these T cells subsets are poorly understood but are clearly dependent on lack of expression of Fas in lpr mice and expression of defective FasL in gld mice. A role for V beta 8+ T cells also has been reported...
  56. ncbi Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo
    R J Mogil
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Int Immunol 7:1451-8. 1995
    ..deletion in mice carrying the lpr/lpr defect, which has been shown to be due to defective production of the CD95/Fas molecule...
  57. ncbi Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
    D Kagi
    Department of Pathology, University of Zurich, Switzerland
    Science 265:528-30. 1994
    Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated...
  58. pmc Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus
    J H Roark
    Wistar Institute, Philadelphia, Pennsylvania 19104
    J Exp Med 181:1157-67. 1995
    ..stain nuclei in a homogenous nuclear (HN) fashion, are diagnostic of systemic lupus erythematosus (SLE) and the MRL-lpr/lpr SLE murine model...
  59. ncbi The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
    G G Singer
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Immunity 1:365-71. 1994
    The role of a cell death-associated gene, fas, in T lymphocyte development and responses to antigen has been analyzed by breeding a transgenic T cell receptor specific for the 81-104 peptide of pigeon cytochrome c into fas-defective MRL-..
  60. ncbi Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody production
    T Giese
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    J Immunol 152:2000-10. 1994
    Mice homozygous for lpr or gld develop autoimmunity and progressive lymphoproliferative disease characterized by the accumulation of an unusual population of functionally impaired B220+, TCR-alpha/beta +, CD4-, CD8- double negative (DN) ..
  61. pmc Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide
    J H Russell
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 90:4409-13. 1993
    ..Mutant lpr/lpr mice exhibit an autoimmune syndrome similar to systemic lupus erythematosus...
  62. pmc Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 14:6136-47. 1995
    Activation of the cell surface receptor Fas/APO-1 (CD95) induces apoptosis in lymphocytes and regulates immune responses...
  63. pmc Enhanced and accelerated lymphoproliferation in Fas-null mice
    M Adachi
    Osaka Bioscience Institute, Japan
    Proc Natl Acad Sci U S A 93:2131-6. 1996
    Fas is a 45-kDa membrane protein that transduces an apoptotic signal. The mouse lymphoproliferation (lpr) mutation is a leaky mutation of Fas. In this study, we examined lymphocyte development in Fas-null mice generated by gene targeting...
  64. ncbi IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice
    C Haas
    Institute of Toxicology, University of Zurich, Switzerland
    J Immunol 158:5484-91. 1997
    MRL/lpr mice develop lymphoproliferation and accelerated autoimmune glomerulonephritis from which they ultimately die...
  65. ncbi The primary site of CD4- 8- B220+ alphabeta T cells in lpr mice: the appendix in normal mice
    S Yamagiwa
    Department of Immunology, Niigata University School of Medicine, Japan
    J Immunol 160:2665-74. 1998
    ..reports on an abundance of CD4- 8- B220+ alphabeta T cells, seen in autoimmune mice carrying the lpr gene (abnormal Fas gene), in any immune organs of normal mice...
  66. pmc Sp3 regulates fas expression in lung epithelial cells
    H Pang
    The Pulmonary Center, Boston University School of Medicine, 80 E Concord Street, Boston, MA 02118, USA
    Biochem J 333:209-13. 1998
    By transducing an apoptotic signal in immune effector cells, Fas has been directly implicated in the control of immunological activity...
  67. pmc Several different cell surface molecules control negative selection of medullary thymocytes
    H Kishimoto
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 190:65-73. 1999
    ..of this idea, we show here that at least three cell surface molecules, namely CD28, CD5, and CD43, contribute to Fas-independent negative selection of the tolerance-susceptible population of heat-stable antigen (HSA)hiCD4+8- cells ..
  68. ncbi Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: altered differentiation and an accelerated response
    S Santulli-Marotto
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 166:5292-9. 2001
    ..In this report, we compare the regulation of anti-Sm B cells in nonautoimmune and autoimmune MRL/Mp-lpr/lpr (MRL/lpr) and bcl-2-22-Tg mice...
  69. ncbi Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice
    H Sekine
    Department of Medicine, Medical University of South Carolina and the Medical Research Service, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29425, USA
    J Immunol 166:6444-51. 2001
    ..in lupus nephritis, mice rendered C3 deficient by targeted deletion were backcrossed for eight generations to MRL/lpr mice, a mouse strain that spontaneously develops lupus-like disease...
  70. ncbi Complement C4 is protective for lupus disease independent of C3
    Shirit Einav
    Center for Blood Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1036-41. 2002
    ..C3 in mediating systemic lupus erythematosus (SLE) was examined using a double-knockout C3(null)C4(null) Fas (CD95)-deficient mouse model...
  71. pmc Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice
    Silvia Bolland
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 195:1167-74. 2002
    ..we have constructed hybrids between FcgammaRIIB(-/-) and the systemic lupus erythematosus (SLE) modifiers yaa and lpr and the susceptibility locus Sle1. Sle1 and B6...
  72. pmc Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
    Marc Pellegrini
    Division of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Proc Natl Acad Sci U S A 100:14175-80. 2003
    We used mutant Fas-deficient (lpr) or Bim-deficient mice to investigate the role of the death receptor and Bcl-2-regulated apoptotic pathways in terminating a physiological T cell response to herpes simplex virus infection...
  73. ncbi Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Immunity 25:417-28. 2006
    ..These findings reveal opposing inflammatory and regulatory roles for TLR7 and TLR9, despite similar tissue expression and signaling pathways. These results have important implications for TLR-directed therapy of autoimmune disease...
  74. ncbi FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis
    Zou Xiang
    Cambridge Institute for Medical Research and the Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2OY, UK
    Nat Immunol 8:419-29. 2007
    ..Our results suggest that FcgammaRIIb controls bone marrow plasma cell persistence and that defects in it may contribute to autoantibody production...
  75. pmc Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity
    Peter B Stranges
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Immunity 26:629-41. 2007
    ..This paradigm is based on the extensive lymphoproliferation and systemic autoimmunity in mice and humans lacking Fas or its ligand...
  76. ncbi The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane
    P L Cohen
    Dept of Medicine, University of North Carolina School of Medicine, Chapel Hill 27599 7280
    Immunol Today 13:427-8. 1992
    The single gene lpr and gld models of spontaneous systemic autoimmunity have attracted much attention in recent years...
  77. pmc Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice
    T Ohteki
    Department of Microbiology, Tohoku University School of Dentistry, Sendai, Japan
    J Exp Med 172:7-12. 1990
    MRL-lpr/lpr mice develop a severe autoimmune disease that resembles systemic lupus erythematosis in humans...
  78. ncbi Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset
    H C Morse
    J Immunol 129:2612-5. 1982
    ..These results suggest that an abnormal proliferating population of T cells in Ipr/Ipr mice aberrantly express B cell surface markers...
  79. ncbi Fas receptor expression on B-lineage cells
    L Mandik
    Wistar Institute, Philadelphia 19104, USA
    Eur J Immunol 25:3148-54. 1995
    ..The lpr defect has been identified as a mutation in the apoptosis-associated Fas receptor (FasR) gene...
  80. pmc Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice
    J Wu
    University of Alabama at Birmingham 35294
    Proc Natl Acad Sci U S A 91:2344-8. 1994
    ..The lpr genetic defect has been identified as a mutation in the Fas apoptosis gene that results in low expression of Fas mRNA...
  81. pmc Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome
    J L Chu
    Specialized Center of Research in Systemic Lupus Erythematosus, Hospital for Special Surgery Cornell University Medical Center, New York 10021
    J Exp Med 181:393-8. 1995
    Fas-deficient lpr and gld mice develop lymphadenopathy due to the accumulation of T cells with an unusual double negative (DN) (CD4-CD8-) phenotype...
  82. ncbi A single injection of Staphylococcus aureus enterotoxin B reduces autoimmunity in MRL/lpr mice
    J A Gonzalo
    Centro de Biologia Molecular, CSIC, Madrid, Spain
    Clin Immunol Immunopathol 71:176-82. 1994
    MRL/Mp-lpr/lpr (MRL/lpr) mice carry a mutation in the Fas gene whose product is involved in the regulation of lymphocyte apoptosis. This mutation is associated with the lpr phenomenon, i.e...
  83. ncbi T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted
    E S Sobel
    Department of Medicine, University of North Carolina, Chapel Hill 27599
    J Immunol 152:6011-6. 1994
    ..we have constructed bone marrow chimeras with Ig heavy chain (lgh) allotype- and I-A-congenic donor B6/lpr mice and I-A-congenic recipients...
  84. ncbi V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice
    D D Bloom
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599
    J Immunol 150:1591-610. 1993
    ..specificity and V-region gene sequences of 41 anti-Sm B cell hybridomas derived from nine anti-Sm-positive MRL/Mp-lpr/lpr mice. The majority of hybridomas are specific for the D peptide of the Sm particle...
  85. pmc Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis
    X Zhang
    University of California, San Diego, La Jolla, California 92093, USA
    J Exp Med 185:1837-49. 1997
    T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated, activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also observed without restimulation, after a longer lag period...
  86. pmc Daxx, a novel Fas-binding protein that activates JNK and apoptosis
    X Yang
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 89:1067-76. 1997
    The Fas cell surface receptor induces apoptosis upon receptor oligomerization. We have identified a novel signaling protein, termed Daxx, that binds specifically to the Fas death domain...
  87. ncbi B cell genotype determines the fine specificity of autoantibody in lpr mice
    V N Kakkanaiah
    Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    J Immunol 159:1027-35. 1997
    ..In humans, anti-Sm Abs are mostly IgG1, and in MRL/lpr mice, IgG2a; both are T-dependent isotypes...
  88. pmc Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus
    C M Lloyd
    Millennium Pharmaceuticals Inc, Cambridge, Massachusetts 02139, USA
    J Clin Invest 100:963-71. 1997
    ..Furthermore, the lack of pulmonary inflammation was found to be due to decreased migration of leukocytes to the lung rather than decreased in situ proliferation of cells...
  89. pmc Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice
    D Balomenos
    The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
    J Clin Invest 101:364-71. 1998
    Congenic MRL-lpr mice homozygous and heterozygous for the IFN-gamma gene disruption were created to assess the role of this pleotropic cytokine on the lymphoaccumulation and lupus-like disease of Fas-defective mice...
  90. ncbi A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice
    O Chan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Immunol 160:51-9. 1998
    ..To test the role of B cells directly, we previously generated autoimmune-prone MRL-lpr/lpr mice that lack B cells...
  91. pmc Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions
    W F Davidson
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:1825-38. 1998
    ..In this report we investigated the possibility that mutations at the Fas (lpr) and Fasl (gld) loci, which prevent Fas-mediated apoptosis and cause an early onset benign lymphoid ..
  92. ncbi Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus
    L Gu
    Department of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 161:6999-7006. 1998
    MRL-lpr/lpr (MRL/lpr) mice are a model of human autoimmune disease...
  93. ncbi Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice
    J L Goulet
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    J Immunol 163:359-66. 1999
    ..To investigate the role of LTs in autoimmune disease, we generated an MRL-lpr/lpr mouse line with a targeted disruption of the 5lo gene...
  94. ncbi Fas and Fas ligand in gut and liver
    M J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Am J Physiol Gastrointest Liver Physiol 278:G354-66. 2000
    ..Perhaps the best-studied death receptor and ligand system is the Fas/Fas ligand (FasL) system, in which FasL, a member of the tumor necrosis factor (TNF) family of death-inducing ..
  95. ncbi Concomitant early appearance of anti-ribonucleoprotein and anti-nucleosome antibodies in lupus prone mice
    Diego Laderach
    INSERM U25, Hopital Necker, 161 rue de Sevres, 75743 Cedex 15, Paris, France
    J Autoimmun 20:161-70. 2003
    ....
  96. ncbi FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease
    Kaori Yajima
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Eur J Immunol 33:1020-9. 2003
    MRL.Fas(lpr/lpr) mice, a model for systemic lupus erythematosus (SLE) and arthritis in humans, have a Fas mutation that results in spontaneous development of systemic autoimmune diseases and a short life span...
  97. ncbi Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections
    Michael J Fuller
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 172:4204-14. 2004
    ....
  98. ncbi Type I IFN protects against murine lupus
    Jonathan D Hron
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 173:2134-42. 2004
    ..However, deficiency for the IFN-RI surprisingly worsened lymphoproliferation, autoantibody production, and end organ disease; animals doubly deficient for IFN-RI and IFN-RII developed ..
  99. ncbi Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation
    Christina E Zielinski
    Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    J Immunol 174:5100-9. 2005
    ..IL-2 production, and single cell calcium signaling of naive CD4+ T cells isolated from Fas-intact MRL/+(Fas-lpr) mice with H-2k-matched B10...
  100. ncbi B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice
    Danielle Bonardelle
    CNRS UPR 9045, Villejuif, France
    J Leukoc Biol 78:1052-9. 2005
    ..However, MRL/lpr autoimmune-prone mice massively overexpress FasL on their T lymphocytes, which render them able to kill Fas+ ..
  101. ncbi Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)
    Sakiko Shimizu
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    J Immunol 175:7185-92. 2005
    MRL/lpr mice develop spontaneous glomerulonephritis that is essentially identical with diffuse proliferative glomerulonephritis (World Health Organization class IV) in human lupus nephritis...

Research Grants38

  1. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
    ..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. [unreadable] [unreadable]..
  2. Roles of MIF and iNOS in SLE-associate inflammation
    Michael Hickey; Fiscal Year: 2007
    ..Using IVM, we will define the regulatory role of NO in the MRL/fas-lpr model of SLE...
  3. BRAIN CELL DEATH IN MRL MICE: TARGETS AND MECHANISMS
    Boris Sakic; Fiscal Year: 2004
    ..abstract_text> ..
  4. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2007
    ..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..
  5. CD40-CD154 Interactions in Cryptosporidial Immunity
    ESTHER PONNURAJ; Fiscal Year: 2004
    ..The results will be important for immunodeficient humans chronically infected with the parasite. ..
  6. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  7. B CELL REPERTOIRE FORMATION
    ANN FEENEY; Fiscal Year: 2009
    ..Together, these studies should give insight into the epigenetic mechanisms and cis-elements which control VH gene rearrangement in fetal and adult pro-B cells. ..
  8. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  9. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    ..The final aim will determine the role of Fas-induced apoptosis in the disease reduction observed in BXSB-p21"7" mice...
  10. Impact of Fli-1 expression on lupus disease development
    Xian Zhang; Fiscal Year: 2007
    ..In preliminary studies for this proposal, we found that genetic reduction of Fli-1 expression in MRL/lpr mice significantly prolonged survival, decreased auto antibody production, and decreased renal pathologic ..
  11. Otitis Media Impact on the Inner Ear
    Dennis Trune; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Receptor Editing in Autoimmune and Normal Mice
    ANN FEENEY; Fiscal Year: 2009
    In this application, we will compare the responses of B cells from MRL/lpr lupus prone mice and non-autoimmune mice to receptor editing signals, testing the hypothesis that lupus-prone strains of mice have misregulated receptor editing ..
  13. MOLECULAR ANALYSIS OF THE ANTIH INFLUENZAE RESPONSE
    ANN FEENEY; Fiscal Year: 2001
    ..We will also further analyze the diversity in the ani-hib response through the use of combinatorial libraries, correlating affinity with the Vh, Vk and CDR3's which are used. ..
  14. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  15. Analysis of Viral Resistance in CMV Retinitis
    DOUGLAS JABS; Fiscal Year: 2005
    ....
  16. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2005
    ..are potent environmental immunostimulants that produce a number of immunopathologic sequelae including lymphoproliferation, hypergammaglobulinemia and overt systemic autoimmunity...
  17. CMV RETINITIS AND VIRAL RESISTANCE
    DOUGLAS JABS; Fiscal Year: 2003
    ....
  18. Sex-based differences in regulatory T cell responses
    MICHELE KOSIEWICZ; Fiscal Year: 2004
    ..The results of these studies will provide important information that can lead to the development of novel therapies for the prevention and treatment of autoimmune disease. ..
  19. STUDIES OF LUNG DISEASES OF HIV TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2009
    ..This research is especially relevant to public health, especially children with AIDS, developing lung diseases at high frequency. ..
  20. ROLE OF COMPLEMENT FACTOR B IN THE PATHOGENESIS OF SLE
    Gary Gilkeson; Fiscal Year: 2004
    ..Bf and the alternative pathway play in autoimmune disease, we bred the Bf knockout genotype to the lupus prone MRL/lpr background...
  21. Requirements for regulatory T cell development
    MICHELE KOSIEWICZ; Fiscal Year: 2003
    ..These experiments may determine the requirements for regulatory T cell development, and thereby, identify pathways that can be therapeutically manipulated to prevent and/or treat autoimmune diseases. ..
  22. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
  23. IMMUNOMODULATORY STRATEGIES IN AUTOIMMUNE GASTRITIS
    MICHELE KOSIEWICZ; Fiscal Year: 2002
    ..This strategy may be used in conjunction with TGFbeta-treated APCs to successfully treat established autoimmune disease. ..
  24. CARDIAC LESIONS IN HIV1 TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2001
    ..End of Abstract) ..
  25. Analyzing and modulating immunoregulatory defects in autoimmune disease.
    Michele M Kosiewicz; Fiscal Year: 2010
    ..abstract_text> ..
  26. PROTEIN PROFILING OF ORAL MUCOSA OF HIV TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2010
    ..This research is especially relevant to public health in view of the high frequency of oral complications (especially candidiasis) in HIV-1 infected individuals. ..
  27. "The alveolar epithelium in lung injury and repair"
    Gustavo Matute Bello; Fiscal Year: 2010
    ..S. each year and is an important cause of morbidity and mortality in hospitalized patients. Our work has shown that Fas-dependent pathways are active in the lungs of patients with ALI, and that stimulation of Fas-dependent pathways ..
  28. Control of Accessibility for V(D) J Recombination
    ANN FEENEY; Fiscal Year: 2006
    ..We will determine if other transcription factors such as Pax5 or Btk will induce rearrangement of other Ig loci, such as Vh or lambda. ..
  29. Development of Cellular Assays of Dengue Virus Infection
    Priscilla Yang; Fiscal Year: 2008
    ..These inhibitors can be used to study how dengue virus interacts with its host, and they may also be useful in developing therapies for the treatment of dengue virus infections. [unreadable] [unreadable] [unreadable]..
  30. Microglial Cell Activation by Thrombin in Stroke
    Jonathan Weinstein; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  31. The FastFasL system in lung injury
    Gustavo Matute Bello; Fiscal Year: 2006
    ..Binding of sFasL to Fas (CD95) in alveolar epithelial cells results in apoptosis and epithelial damage...
  32. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
    ..In the MRL/lpr mouse model of lupus, macrophages and mesangial cells are hyperresponsive to immune stimuli as evidenced by ..
  33. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  34. CHEMOKINES IN LUNG DISEASE OF HIV1 TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2003
    ..4- To determine whether blocking or deleting specific chemokines or their receptors and overexpressing some chemokine receptors alter the development of lymphocytic interstitial pneumonitis. ..
  35. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  36. OCULAR IMMUNOPATHOLOGY IN AUTOIMMUNE MODELS
    DOUGLAS JABS; Fiscal Year: 2001
    ..The 1pr mutation produces defective Fas antigen, which results in defective lymphocytic apoptosis and accelerates the autoimmune disease...