Fam126a

Summary

Gene Symbol: Fam126a
Description: family with sequence similarity 126, member A
Alias: AB030242, Drctnnb1a, hyccin, down-regulated by CTNNB1 protein A
Species: mouse

Top Publications

  1. pmc Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
    Stephen P J Fancy
    Institute for Regeneration Medicine, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 23:1571-85. 2009
  2. pmc The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane
    Jeremy M Baskin
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Cell Biol 18:132-8. 2016
  3. pmc Hyccin, the molecule mutated in the leukodystrophy hypomyelination and congenital cataract (HCC), is a neuronal protein
    Elisabetta Gazzerro
    Muscular and Neurodegenerative Disease Unit, G Gaslini Institute, University of Genoa, Genoa, Italy
    PLoS ONE 7:e32180. 2012
  4. ncbi Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin
    T Kawasoe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Cancer Res 60:3354-8. 2000

Scientific Experts

  • Elisabetta Gazzerro
  • Jeremy M Baskin
  • Stephen P J Fancy
  • Carlo Minetti
  • Karin M Reinisch
  • Mirko Messa
  • Federico Zara
  • Pietro De Camilli
  • Michael S Oh
  • Roberta Biancheri
  • Curtis M Schauder
  • Tobias C Walther
  • Andrea Raimondi
  • Stefania Assereto
  • Mikael Simons
  • Simona Baldassari
  • Xudong Wu
  • Romain Christiano
  • T Kawasoe
  • Nader Sanai
  • Sergio E Baranzini
  • Karen Amanda Irvine
  • Chao Zhao
  • David H Rowitch
  • Dong In Yuk
  • Sovann Kaing
  • Robin J M Franklin
  • H Ishiguro
  • S Satoh
  • Y Nakamura
  • Y Miyoshi
  • T Nishiwaki
  • M Fujita
  • Y Daigo
  • N Miwa
  • M Ogawa
  • Y Nagasawa
  • Y Furukawa

Detail Information

Publications4

  1. pmc Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
    Stephen P J Fancy
    Institute for Regeneration Medicine, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 23:1571-85. 2009
    ..Evidence of Wnt pathway activity in human MS lesions suggests that its dysregulation might contribute to inefficient myelin repair in human neurological disorders...
  2. pmc The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane
    Jeremy M Baskin
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Cell Biol 18:132-8. 2016
    ..Hypomyelination and congenital cataract (HCC), one of these disorders, is caused by mutations in FAM126A, a gene of unknown function...
  3. pmc Hyccin, the molecule mutated in the leukodystrophy hypomyelination and congenital cataract (HCC), is a neuronal protein
    Elisabetta Gazzerro
    Muscular and Neurodegenerative Disease Unit, G Gaslini Institute, University of Genoa, Genoa, Italy
    PLoS ONE 7:e32180. 2012
    ..HCC is caused by deficiency of Hyccin, a protein whose biological role has not been clarified yet...
  4. ncbi Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin
    T Kawasoe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Cancer Res 60:3354-8. 2000
    ..Here we report isolation of a novel murine gene, Drctnnb1a (down-regulated by Ctnnb1, a), the expression of which was experimentally down-regulated in response to the ..