F7

Summary

Gene Symbol: F7
Description: coagulation factor VII
Alias: AI132620, Cf7, FVII, coagulation factor VII, serum prothrombin conversion accelerator
Species: mouse

Top Publications

  1. pmc Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Thromb Haemost 107:951-61. 2012
  2. pmc Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa)
    R Gopalakrishnan
    Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX 75703, USA
    J Thromb Haemost 8:301-10. 2010
  3. ncbi Plasma elimination kinetics for factor VII are independent of its activation to factor VIIa and complex formation with plasma inhibitors
    Lars C Petersen
    Haemostasis Biology, Health Care Discovery, Novo Nordisk, Maalov, Denmark
    Thromb Haemost 101:818-26. 2009
  4. pmc A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden
    Alister P W Funnell
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2052, Australia
    Am J Hum Genet 92:460-7. 2013
  5. pmc Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa
    C A Clark
    Department of Cellular and Molecular Biology, Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA Department of Medicine, Malmo University Hospital, University of Lund, Malmo, Sweden Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, Oklahoma City, OK, USA
    J Thromb Haemost 10:2383-91. 2012
  6. pmc AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage
    Christopher Binny
    University College London Cancer Institute, London, UK
    Blood 119:957-66. 2012
  7. pmc Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome
    Patricia Redecha
    Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:3453-61. 2008
  8. pmc Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo
    Paris Margaritis
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA corrected
    Blood 117:3974-82. 2011
  9. doi Activation peptides prolong the murine plasma half-life of human factor VII
    Linda Johansson
    Haemostasis Biochemistry, Novo Nordisk A S, Måløv, Denmark
    Blood 117:3445-52. 2011
  10. pmc Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivo in mice
    Zhiwei Hu
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    BMC Cancer 10:235. 2010

Research Grants

Scientific Experts

  • ELLIOT ROSEN
  • Paris Margaritis
  • Lars Christian Petersen
  • Mirko Pinotti
  • Zhiwei Hu
  • J C Chan
  • H Xu
  • F J Castellino
  • Francis J Castellino
  • Alister P W Funnell
  • Christopher Binny
  • C A Clark
  • Prosenjit Sen
  • L V M Rao
  • U Hedner
  • Linda Johansson
  • U R Pendurthi
  • R Gopalakrishnan
  • Zhi Xu
  • Victoria A Ploplis
  • Kazuhiko Shinagawa
  • Majed N Aljamali
  • Patricia Redecha
  • V A Ploplis
  • M Aasrum
  • E Idusogie
  • Benoit Ballester
  • Duncan T Odom
  • Ka Sin Mak
  • Merlin Crossley
  • Jon Burdach
  • Kathryn M Stowell
  • Richard C M Pearson
  • Natisha Magan
  • Michael D Wilson
  • Paul Flicek
  • Frederic P Lemaigre
  • Edward G D Tuddenham
  • John H McVey
  • L Vijaya Mohan Rao
  • Andrew M Davidoff
  • John T Gray
  • Charles T Esmon
  • Adrian J Thrasher
  • Yunyu Spence
  • Christopher L Morton
  • R Vatsyayan
  • Ramakrishnan Gopalakrishnan
  • Suzanne M K Buckley
  • Amit C Nathwani
  • Jenny McIntosh
  • Ulla Hedner
  • Marco Della Peruta
  • Alice F Tarantal
  • C T Esmon
  • Curtis A Clark
  • Usha R Pendurthi
  • Simon N Waddington
  • Hanna Kymäläinen
  • Egon Persson
  • Hermann Pelzer
  • Ditte M Karpf
  • Lene Hansen
  • Haifeng Xu
  • T C Allen
  • R C Nayak
  • S Ghosh
  • F Noria
  • D L Donahue
  • M J Sandoval-Cooper
  • H Menchen
  • Wolfram Ruf
  • Nigel Mackman
  • Shing Jen Tai
  • Claus Werner Franzke
  • Guillermina Girardi
  • Ralph Bunte
  • Katherine A High
  • Rodney M Camire
  • Alexander Schlachterman
  • Elise Roy
  • Z Liang
  • D R Stauffer
  • Hans Prydz
  • D Collen
  • P Carmeliet
  • B N Chukwumezie
  • A Cooper
  • J A Wilberding
  • J P Geng

Detail Information

Publications29

  1. pmc Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Thromb Haemost 107:951-61. 2012
    ..Measurement of endogenous plasma levels of FVII in wild-type, EPCR-deficient and EPCR-over expressing mice showed slightly lower levels of FVII in EPCR-over ..
  2. pmc Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa)
    R Gopalakrishnan
    Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX 75703, USA
    J Thromb Haemost 8:301-10. 2010
    ..Given the short biological half-life of rFVIIa, it is unclear how rFVIIa could be effective in prophylactic treatment...
  3. ncbi Plasma elimination kinetics for factor VII are independent of its activation to factor VIIa and complex formation with plasma inhibitors
    Lars C Petersen
    Haemostasis Biology, Health Care Discovery, Novo Nordisk, Maalov, Denmark
    Thromb Haemost 101:818-26. 2009
    The mechanism for the elimination of factor VII (FVII) from the circulation is unknown, just as it is unclear how activation of FVII to FVIIa and subsequent complex formation with antithrombin III (AT) or alpha2-macroglobulin (alpha2M) ..
  4. pmc A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden
    Alister P W Funnell
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2052, Australia
    Am J Hum Genet 92:460-7. 2013
    ..Taken together, our findings establish ONECUT transcription factors as the missing hemophilia B Leyden regulators that operate through the -5/-6 site...
  5. pmc Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa
    C A Clark
    Department of Cellular and Molecular Biology, Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA Department of Medicine, Malmo University Hospital, University of Lund, Malmo, Sweden Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, Oklahoma City, OK, USA
    J Thromb Haemost 10:2383-91. 2012
    ..Recent studies show that activated factor VII (FVIIa) binds to the endothelial cell protein C receptor (EPCR) on the vascular endothelium; however, the importance of this interaction in hemostasis or pathophysiology is unknown...
  6. pmc AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage
    Christopher Binny
    University College London Cancer Institute, London, UK
    Blood 119:957-66. 2012
    ..viral vector (AAV)-mediated gene transfer in the perinatal period in animal models of severe congenital factor VII (FVII) deficiency, a disease associated with early postnatal life-threatening hemorrhage...
  7. pmc Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome
    Patricia Redecha
    Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:3453-61. 2008
    ..Our results suggest that TF/FVIIa/PAR2 signaling mediates neutrophil activation and fetal death in APS and that statins may be a good treatment for women with aPL-induced pregnancy complications...
  8. pmc Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo
    Paris Margaritis
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA corrected
    Blood 117:3974-82. 2011
    ..To explore this in a hemophilic mouse model, we characterized 2 variants of murine activated FVII (mFVIIa-VEAY and mFVIIa-DVQ) with modified catalytic domains, based on recombinant human FVIIa (rhFVIIa) variants...
  9. doi Activation peptides prolong the murine plasma half-life of human factor VII
    Linda Johansson
    Haemostasis Biochemistry, Novo Nordisk A S, Måløv, Denmark
    Blood 117:3445-52. 2011
    Coagulation factors VII (FVII), IX (FIX), X (FX), and protein C share the same domain organization but display very different plasma half-lives...
  10. pmc Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivo in mice
    Zhiwei Hu
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    BMC Cancer 10:235. 2010
    The objective of this study was to develop a ligand-targeted photodynamic therapy (tPDT) by conjugating factor VII (fVII) protein with photosensitiser verteporfin in order to overcome the poor selectivity and enhance the effect of non-..
  11. pmc Factor VII deficiency impairs cutaneous wound healing in mice
    Zhi Xu
    WM Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States of America
    Mol Med 16:167-76. 2010
    ..We reported the use of a dermal punch model to demonstrate that low-expressing FVII mice (approximately 1% of wild type [WT]) exhibited impaired skin wound healing compared with WT controls...
  12. pmc A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice
    Kazuhiko Shinagawa
    University of Notre Dame, Notre Dame, IN 46556, USA
    Am J Physiol Lung Cell Mol Physiol 296:L763-70. 2009
    ..after ovalbumin (OVA) challenge, a response that was diminished in comparably challenged low-expressing coagulation factor VII (FVII(tTA/tTA)) mice...
  13. pmc Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice
    H Xu
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 217:362-71. 2009
    Mice genetically modified to produce low levels (approximately 1% of wild-type) of coagulation FVII presented with echocardiographic evidence of heart abnormalities...
  14. ncbi Characterization of a cDNA encoding murine coagulation factor VII
    E Idusogie
    Department of Chemistry and Biochemistry, University of Notre Dame, Indiana 46556, USA
    Thromb Haemost 75:481-7. 1996
    The cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a lambda Zap cDNA library generated from murine liver mRNA...
  15. pmc Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality
    Majed N Aljamali
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Clin Invest 118:1825-34. 2008
    ....
  16. ncbi A coagulation factor VII deficiency protects against acute inflammatory responses in mice
    H Xu
    WM Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 210:488-96. 2006
    ..Thus, the potential protective effects in vivo of a genetic-based reduction in FVII levels have been investigated in a murine model of acute inflammation, namely lipopolysaccharide (LPS)-induced ..
  17. ncbi Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII
    Elliot D Rosen
    Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut Street, IB130, Indianapolis, IN 46202, USA
    Blood Cells Mol Dis 36:131-4. 2006
    b>FVII(tTA/-) mice are heterozygous for the FVII- null allele and a gene-targeted allele expressing very low levels of FVII...
  18. ncbi Generation of genetically-altered mice producing very low levels of coagulation factorVII
    Elliot D Rosen
    W M Keck Center forTransgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46202, USA
    Thromb Haemost 94:493-7. 2005
    It has been shown earlier that mice with a total targeted deletion of the factorVII gene (FVII(-/-)) die perinatally, thereby precluding study of adult animals with this total deficiency...
  19. ncbi Daily and circadian rhythms of tissue factor pathway inhibitor and factor VII activity
    Mirko Pinotti
    Deparment of di Biochimica e Biologia Molecolare, Universita di Ferrara, Via L Borsari 46, 44100 Ferrara, Italia
    Arterioscler Thromb Vasc Biol 25:646-9. 2005
    Diurnal variations in levels of factor VII (FVII), FVIII, proteins C and S, antithrombin, plasminogen activator inhibitor-1, prothrombin fragment F1+2, and D-dimers in healthy humans point to the existence of circadian rhythms of ..
  20. ncbi Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development
    M Aasrum
    Biotechnology Center of Oslo, P O B 1125 Blindern, N 0317 Oslo, Norway
    Biochemistry (Mosc) 67:25-32. 2002
    ..factor (TF) is the main initiator of the coagulation system and functions as a cell surface receptor for coagulation factor VII (FVII). Knockout studies have shown that TF deficiency results in lethality around embryonic day (E) 8...
  21. ncbi Gene targeting in hemostasis. Factor VII
    J C Chan
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, USA
    Front Biosci 6:D98-D104. 2001
    Factor VII (FVII), in concert with its natural cofactor and receptor, Tissue Factor (TF), initiates the process of blood coagulation following vascular injury...
  22. pmc Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice
    J C Chan
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Clin Invest 105:897-903. 2000
    To determine whether an additional loss of the coagulation factor VII (FVII) gene influenced the coagulopathy observed in protein C gene-deficient (PC(-/-)) embryos and neonates, we crossed mice doubly heterozygous for the factor VII (..
  23. pmc Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit
    J C Chan
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, B 3000 Leuven, Belgium
    J Clin Invest 103:475-82. 1999
    ..allele (tfpi delta) lacking its Kunitz-type domain-1 (TFPI+/delta) and for a deficiency of the factor VII gene (FVII+/-) were mated to generate 309 postnatal and 205 embryonic day 17.5 (E17...
  24. ncbi Chromosomal arrangement of the murine coagulation factor VII and factor X genes
    Z Liang
    Thromb Haemost 80:524-5. 1998
  25. ncbi Characterization of transcriptional regulatory elements in the promoter region of the murine blood coagulation factor VII gene
    D R Stauffer
    Department of Chemistry and Biochemistry, University of Notre Dame, Indiana 46556, USA
    J Biol Chem 273:2277-87. 1998
    To identify the 5' sequences of the murine coagulation factor VII (fVII) gene that resulted in its efficient transcription, a variety of 5'-flanking sequences up to 7 kilobase pairs upstream of the translation ATG initiation codon were ..
  26. ncbi Mice lacking factor VII develop normally but suffer fatal perinatal bleeding
    E D Rosen
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Nature 390:290-4. 1997
    Blood coagulation in vivo is initiated by factor VII (FVII) binding to its cellular receptor tissue factor (TF)...
  27. ncbi Nucleotide structure and characterization of the murine blood coagulation factor VII gene
    E Idusogie
    Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA
    Thromb Haemost 76:957-64. 1996
    The gene encoding murine coagulation factor VII (fVII) has been cloned. Seven introns and eight exons are present, with the introns positioned as splice junctions between the major domain units of the protein...

Research Grants2

  1. COAGULATION INITIATION IN FACTOR VII DEFICIENT MICE
    ELLIOT ROSEN; Fiscal Year: 2003
    ..of this research is to determine the in vivo role of coagulation factors, specifically that of Factor VII (FVII). FVII is generally accepted to play a key role in the initiation of coagulation following vascular injury...