Ezh2

Summary

Gene Symbol: Ezh2
Description: enhancer of zeste 2 polycomb repressive complex 2 subunit
Alias: Enx-1, Enx1h, KMT6, mKIAA4065, histone-lysine N-methyltransferase EZH2, enhancer of zeste homolog 2
Species: mouse

Top Publications

  1. ncbi Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene
    O Hobert
    Department of Molecular Biology, Max Planck Institut fur Biochemie, Am Klopferspitz, Martinsried, Germany
    Mech Dev 55:171-84. 1996
  2. pmc Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
    Raphael Margueron
    Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, NY 10016, USA
    Mol Cell 32:503-18. 2008
  3. pmc Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1
    M E Gonzalez
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 28:843-53. 2009
  4. pmc A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1
    Masamitsu Negishi
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 5:e12373. 2010
  5. pmc Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome
    Kathrin Plath
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Biol 167:1025-35. 2004
  6. pmc Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
    G Laible
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    EMBO J 16:3219-32. 1997
  7. pmc The polycomb-group gene Ezh2 is required for early mouse development
    D O'Carroll
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Mol Cell Biol 21:4330-6. 2001
  8. ncbi Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells
    Winifred Mak
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London W12 0NN, United Kingdom
    Curr Biol 12:1016-20. 2002
  9. ncbi Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
    I Hsin Su
    Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA
    Nat Immunol 4:124-31. 2003
  10. ncbi Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
    Sylvia Erhardt
    Wellcome Trust Cancer Research UK Institute, University of Cambridge, Cambridge CB2 1QR, UK
    Development 130:4235-48. 2003

Research Grants

  1. LIPID PEROXIDATION IN ALCOHOLIC LIVER DISEASE
    Samuel William French; Fiscal Year: 2010

Scientific Experts

  • Kathrin Plath
  • Goro Sashida
  • Woo Kyun Bae
  • Zhu Shen
  • Mehdi Pirouz
  • Samuel William French
  • Julian Puppe
  • Tanya Shaw
  • Jelena Mann
  • M van Lohuizen
  • Houjian Cai
  • Alexandros Tzatsos
  • Xavier Miro
  • I Hsin Su
  • Stuart H Orkin
  • Falak Sher
  • Alexander Tarakhovsky
  • Haruhiko Koseki
  • Xiaohua Shen
  • Raphael Margueron
  • Danny Reinberg
  • Jeannie T Lee
  • Atsushi Iwama
  • Masamitsu Negishi
  • Hainan Chen
  • Elena Ezhkova
  • Aster H Juan
  • Arie P Otte
  • Jing Zhao
  • Antoine H F M Peters
  • Adrian P Bracken
  • Kristian Helin
  • Paul Delgado-Olguín
  • Makiko Mochizuki-Kashio
  • Shihori Yokobayashi
  • Satoru Miyagi
  • Sjef Copray
  • Erik Boddeke
  • Gang Li
  • Rémi Terranova
  • Vittorio Sartorelli
  • Jianmin Zhang
  • Chen Davidovich
  • Juan Zhang
  • Devram Sampat Ghorpade
  • Marieta Caganova
  • Diego Pasini
  • Li Chen
  • Hsiao Lei Lai
  • Stefan F Pinter
  • Chang Ching Yang
  • Christine E Seidman
  • Seunghee Lee
  • Aibin He
  • Wei Qi
  • Satomi Tanaka
  • Thomas Jenuwein
  • Christopher G Abraham
  • B A French
  • Ji Min Lee
  • Camille Simon
  • Gerard L Brien
  • Huafeng Xie
  • A Herrera-Merchan
  • Tobias Neff
  • Dong Myung Shin
  • Benoit G Bruneau
  • Zhu Ningxia
  • Tetsuhiro Chiba
  • Stefania Mejetta
  • Miguel Vidal
  • Nicole A Rapicavoli
  • Susan C Wu
  • Heather M O'Hagan
  • Gerard Cagney
  • Cheryl M Koh
  • Cheng Ran Xu
  • Laurie A Wyngaarden
  • Toshiro K Ohsumi
  • Reut Hod-Dvorai
  • Mark Borowsky
  • Atsunori Saraya
  • Takaaki Konuma
  • Nicole Stokes
  • Chunhua Lu
  • Swarnali Acharyya
  • Youngsook Lee
  • Xueying Gu
  • Rita Bottino
  • BORIS G WILSON

Detail Information

Publications104 found, 100 shown here

  1. ncbi Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene
    O Hobert
    Department of Molecular Biology, Max Planck Institut fur Biochemie, Am Klopferspitz, Martinsried, Germany
    Mech Dev 55:171-84. 1996
    ..In adult stages we also find Enx-1 expression to be restricted to specific tissues, including spleen, testis and placenta...
  2. pmc Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
    Raphael Margueron
    Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, NY 10016, USA
    Mol Cell 32:503-18. 2008
    ..We report that the mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes but exhibit contrasting repressive roles...
  3. pmc Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1
    M E Gonzalez
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 28:843-53. 2009
    Increased levels of enhancer of zeste homolog 2 (EZH2), a critical regulator of cellular memory, are associated with negative estrogen receptor (ER) expression and disease progression in breast cancer...
  4. pmc A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1
    Masamitsu Negishi
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 5:e12373. 2010
    ..However, how PcG complexes target and contribute to stable gene silencing of the Ink4a/Arf locus remains little understood...
  5. pmc Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome
    Kathrin Plath
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Biol 167:1025-35. 2004
    ..Our results implicate mPRC1 in X inactivation and suggest that the regulated assembly of PcG protein complexes on the Xi contributes to this multistep process...
  6. pmc Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
    G Laible
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    EMBO J 16:3219-32. 1997
    ..We describe the isolation of human (EZH2) and mouse (Ezh1) homologues of the Drosophila Polycomb-group (Pc-G) gene Enhancer of zeste [E(z)], a crucial ..
  7. pmc The polycomb-group gene Ezh2 is required for early mouse development
    D O'Carroll
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Mol Cell Biol 21:4330-6. 2001
    ..Although E(Z)-related proteins have not (yet) been directly associated with HMTase activity, mammalian Ezh2 is a member of a histone deacetylase complex...
  8. ncbi Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells
    Winifred Mak
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London W12 0NN, United Kingdom
    Curr Biol 12:1016-20. 2002
    ..The association of Eed/Enx1 complexes is mitotically stable, suggesting a mechanism for the maintenance of imprinted X inactivation in these cells...
  9. ncbi Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
    I Hsin Su
    Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA
    Nat Immunol 4:124-31. 2003
    Polycomb group protein Ezh2 is an essential epigenetic regulator of embryonic development in mice, but its role in the adult organism is unknown...
  10. ncbi Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
    Sylvia Erhardt
    Wellcome Trust Cancer Research UK Institute, University of Cambridge, Cambridge CB2 1QR, UK
    Development 130:4235-48. 2003
    Enhancer of zeste 2 (Ezh2), a SET domain-containing protein, is crucial for development in many model organisms, including early mouse development...
  11. ncbi Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 23:4930-7. 2004
    ..b>Enhancer of zeste homolog 2 (Ezh2), a member of this large protein family, has also been shown to be deregulated in different tumor ..
  12. pmc Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
    Diego Pasini
    European Institute of Oncology, Milan, Italy
    EMBO J 23:4061-71. 2004
    SUZ12 is a recently identified Polycomb group (PcG) protein, which together with EZH2 and EED forms different Polycomb repressive complexes (PRC2/3)...
  13. pmc The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
    Giuseppina Caretti
    Muscle Gene Expression Group, Laboratory of Muscle Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 18:2627-38. 2004
    The Ezh2 protein endows the Polycomb PRC2 and PRC3 complexes with histone lysine methyltransferase (HKMT) activity that is associated with transcriptional repression...
  14. ncbi Polycomb group protein ezh2 controls actin polymerization and cell signaling
    I Hsin Su
    Laboratory of Lymphocyte Signaling, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 121:425-36. 2005
    Polycomb group protein Ezh2, one of the key regulators of development in organisms from flies to mice, exerts its epigenetic function through regulation of histone methylation...
  15. ncbi Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5
    Eric Bertolino
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Immunol 6:836-43. 2005
    ..Therefore, STAT5 functions at a distinct step in regulating distal V(H) recombination in relation to the transcription factor Pax5 and histone methyltransferase Ezh2.
  16. ncbi Juxtaposed Polycomb complexes co-regulate vertebral identity
    Se Young Kim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Development 133:4957-68. 2006
    ..Whereas EED and BMI1 formed separate biochemical entities with EzH2 and Ring1B, respectively, in mid-gestation embryos, YY1 engaged in both Polycomb complexes...
  17. pmc The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    Adrian P Bracken
    Centre for Epigenetics, Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen 2200, Denmark
    Genes Dev 21:525-30. 2007
    ..to repress the INK4A-ARF locus requires its direct association and is dependent on the continued presence of the EZH2-containing Polycomb-Repressive Complex 2 (PRC2) complex...
  18. ncbi The transcriptional repression by NIPP1 is mediated by Polycomb group proteins
    Nivedita Roy
    Laboratory of Biosignaling and Therapeutics, Department of Molecular Cell Biology, KULeuven, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1769:541-5. 2007
    ..Here we show that the transcriptional repression by NIPP1 is alleviated by the RNAi-mediated knockdown of EED and EZH2, two core components of the Polycomb Repressive Complex 2 (PRC2), and by the overexpression of a catalytically dead ..
  19. doi MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis
    Chung Fai Wong
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
    J Biol Chem 283:9836-43. 2008
    ..Through a bioinformatics approach, we identified the histone methyltransferase, Enhancer of Zeste homolog 2 (Ezh2), as a potential target of miR-26a...
  20. doi Differentiation of neural stem cells into oligodendrocytes: involvement of the polycomb group protein Ezh2
    Falak Sher
    Department of Neuroscience, University Medical Centre Groningen, Groningen, The Netherlands
    Stem Cells 26:2875-83. 2008
    ..b>Enhancer of zeste homolog 2 (Ezh2) is a Polycomb group protein involved in stem cell renewal and maintenance by inducing gene ..
  21. doi MYC stimulates EZH2 expression by repression of its negative regulator miR-26a
    Sandrine Sander
    Institute of Physiological Chemistry, University of Ulm, Ulm, Germany
    Blood 112:4202-12. 2008
    ..could show that ectopic expression of miR-26a influenced cell cycle progression by targeting the bona fide oncogene EZH2, a Polycomb protein and global regulator of gene expression yet unknown to be regulated by miRNAs...
  22. pmc Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
    Jing Zhao
    Howard Hughes Medical Institute, Boston, MA 02115, USA
    Science 322:750-6. 2008
    ..PRC2 is initially recruited to the X by RepA RNA, with Ezh2 serving as the RNA binding subunit. The antisense Tsix RNA inhibits this interaction...
  23. pmc EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
    Xiaohua Shen
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 32:491-502. 2008
    ..b>EZH2, the catalytic subunit of PRC2, has been reported as the sole histone methyltransferase that methylates H3K27 and ..
  24. pmc Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus
    Alexandros Tzatsos
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 106:2641-6. 2009
    ..Ndy1 counteracts the senescence-associated down-regulation of Ezh2, a component of polycomb-repressive complex (PRC) 2, via a JmjC domain-dependent process leading to the global and ..
  25. pmc Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 136:1122-35. 2009
    ..Here, we show that an essential PRC component, Ezh2, is expressed in epidermal progenitors but diminishes concomitant with embryonic differentiation and with postnatal ..
  26. pmc Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus
    Hainan Chen
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 23:975-85. 2009
    ..Here we show that Enhancer of zeste homolog 2 (Ezh2), a histone methyltransferase and component of a Polycomb group (PcG) protein complex, represses ..
  27. pmc Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia
    Xin Li
    Department of Pathology, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Pathol 175:1246-54. 2009
    The Polycomb group protein enhancer of zeste homolog 2 (EZH2), which has roles during development of numerous tissues, is a critical regulator of cell type identity...
  28. doi Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition
    Yusuke Hirabayashi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Neuron 63:600-13. 2009
    ..Inactivation of PcG by knockout of the Ring1B or Ezh2 gene or Eed knockdown prolonged the neurogenic phase of NPCs and delayed the onset of the astrogenic phase...
  29. pmc Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
    Jamy C Peng
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 139:1290-302. 2009
    ..Genome-wide ChIP-seq analyses of Jarid2, Ezh2, and Suz12 binding reveal that Jarid2 and PRC2 occupy the same genomic regions...
  30. pmc Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells
    Xiaohua Shen
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Cell 139:1303-14. 2009
    ..Our results demonstrate that dynamic regulation of Polycomb complex activity orchestrated by JMJ balances self-renewal and differentiation, highlighting the involvement of chromatin dynamics in cell-fate transitions...
  31. pmc Jarid2 and PRC2, partners in regulating gene expression
    Gang Li
    Howard Hughes Medical Institute, New York University Medical School, New York, New York 10016, USA
    Genes Dev 24:368-80. 2010
    ..components of the Polycomb-Repressive Complex 2 (PRC2) including the histone H3 Lys 27 (H3K27) methyltransferase Ezh2. How mammalian PRC2 accesses chromatin is unclear...
  32. pmc Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation
    Emily Walker
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada
    Cell Stem Cell 6:153-66. 2010
    ..We describe the role of PCL2 in both modulating transcription of ESC self-renewal genes in undifferentiated ESCs as well as developmental regulators during early commitment and differentiation...
  33. pmc Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
    LiFeng Wang
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:7317-22. 2010
    ..Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase Ezh2 on Wnt genes...
  34. doi The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells
    Ryutaro Aoki
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Hepatol 52:854-63. 2010
    ..We have previously shown that Bmi1, a core component of PRC1, tightly regulates the self-renewal of hepatic stem/progenitor cells...
  35. pmc Regulation of tumor angiogenesis by EZH2
    Chunhua Lu
    Department of Gynecologic Oncology, U T M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 18:185-97. 2010
    ..Here, we show that increased Zeste homolog 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome...
  36. doi Ezh2 expression in astrocytes induces their dedifferentiation toward neural stem cells
    Falak Sher
    Department of Neuroscience, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Cell Reprogram 13:1-6. 2011
    Recently, we have demonstrated the expression of the polycomb group protein Ezh2 in embryonic and adult neural stem cells...
  37. pmc Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
    Syuzo Kaneko
    Howard Hughes Medical Institute, New York University School of Medicine, New York, 10016, USA
    Genes Dev 24:2615-20. 2010
    b>Ezh2 functions as a histone H3 Lys 27 (H3K27) methyltransferase when comprising the Polycomb-Repressive Complex 2 (PRC2). Trimethylation of H3K27 (H3K27me3) correlates with transcriptionally repressed chromatin...
  38. pmc Genome-wide identification of polycomb-associated RNAs by RIP-seq
    Jing Zhao
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Mol Cell 40:939-53. 2010
    ..We provide evidence for direct RNA-protein interactions, most likely via the Ezh2 subunit...
  39. pmc EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 25:485-98. 2011
    ..Here, we conditionally target H3K27 methyltransferases Ezh2 and Ezh1 to address their roles in mouse skin homeostasis...
  40. pmc Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells
    Aster H Juan
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal, and Skin Diseases NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 25:789-94. 2011
    ..Here, we report that EZH2, the enzymatic subunit of the Polycomb-repressive complex 2 (PRC2), is expressed in both Pax7+/Myf5⁻ stem cells ..
  41. pmc Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas
    Cheng Ran Xu
    Institute for Regenerative Medicine, Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 332:963-6. 2011
    ..acetyltransferase P300, recruited via bone morphogenetic protein signaling, and the histone methyltransferase Ezh2 have modulatory roles in the fate choice...
  42. pmc Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability
    Susan C Wu
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:28511-9. 2011
    The H3K27 histone methyltransferase, Ezh2 (enhancer of zeste 2), is a Polycomb group protein that plays important roles in many biological processes including cellular differentiation, stem cell biology, and cancer development...
  43. doi Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb
    Laurie A Wyngaarden
    Developmental and Stem Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 138:3759-67. 2011
    ..Using conditional mutagenesis at different time points, we show that the histone methyltransferase Ezh2 is an upstream regulator of anteroposterior prepattern at an early stage...
  44. pmc Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms
    Cheryl M Koh
    Departments of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Oncotarget 2:669-83. 2011
    b>EZH2 is part of the PRC2 polycomb repressive complex that is overexpressed in multiple cancer types and has been implicated in prostate cancer initiation and progression...
  45. doi Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells
    Makiko Mochizuki-Kashio
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Blood 118:6553-61. 2011
    ..Here we show that Ezh2, a core component of PRC2, is essential for fetal, but not adult, HSCs...
  46. pmc Polycomb repressive complex 2 regulates normal development of the mouse heart
    Aibin He
    Department of Cardiology, Children s Hospital Boston, MA, USA
    Circ Res 110:406-15. 2012
    ..Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, which establishes H3K27me3 repressive epigenetic marks that promote tissue-specific differentiation by silencing ectopic gene programs...
  47. pmc UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
    Seunghee Lee
    Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Dev Cell 22:25-37. 2012
    ....
  48. doi Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
    A Herrera-Merchan
    Stem Cell Aging Group, Spanish National Cardiovascular Research Center CNIC, E 28029 Madrid, Spain
    Nat Commun 3:623. 2012
    Recent evidence shows increased and decreased expression of Ezh2 in cancer, suggesting a dual role as an oncogene or tumour suppressor...
  49. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
    ..The Polycomb histone methyltransferase Ezh2 stabilizes transcription by depositing repressive marks during development that persist into adulthood(3-9), but ..
  50. pmc Polycomb repressive complex 2 is required for MLL-AF9 leukemia
    Tobias Neff
    Dana Farber Children s Hospital Cancer Center, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:5028-33. 2012
    ..We used conditional alleles for the PRC2 components enhancer of zeste 2 (Ezh2) and embryonic ectoderm development (Eed) to characterize the role of PRC2 function in leukemia development and ..
  51. doi Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
    Satomi Tanaka
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Blood 120:1107-17. 2012
    b>EZH2, a catalytic component of the polycomb repressive complex 2, trimethylates histone H3 at lysine 27 (H3K27) to repress the transcription of target genes...
  52. pmc Dynamic changes in Ezh2 gene occupancy underlie its involvement in neural stem cell self-renewal and differentiation towards oligodendrocytes
    Falak Sher
    Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e40399. 2012
    The polycomb group protein Ezh2 is an epigenetic repressor of transcription originally found to prevent untimely differentiation of pluripotent embryonic stem cells...
  53. pmc Maintenance of adult cardiac function requires the chromatin factor Asxl2
    Hsiao Lei Lai
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    J Mol Cell Cardiol 53:734-41. 2012
    ..Instead, Asxl2 and the histone methyltansferase Ezh2 co-localize to β-MHC promoter, suggesting that Asxl2 directly represses β-MHC...
  54. doi Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
    Gerard L Brien
    The Smurfit Institute of Genetics, Trinity College Dublin, Ireland
    Nat Struct Mol Biol 19:1273-81. 2012
    ....
  55. pmc TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e12479. 2010
    ..This regulation coincides with elevated levels of muscle derived TNFalpha that is also under IKKbeta and NF-kappaB control...
  56. pmc Nitric oxide and KLF4 protein epigenetically modify class II transactivator to repress major histocompatibility complex II expression during Mycobacterium bovis bacillus Calmette-Guerin infection
    Devram Sampat Ghorpade
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    J Biol Chem 288:20592-606. 2013
    ..of macrophages was essential to orchestrate the epigenetic modifications mediated by histone methyltransferase EZH2 or miR-150 and thus calibrate CIITA/MHC-II expression...
  57. pmc Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
    Marieta Caganova
    J Clin Invest 123:5009-22. 2013
    ..The histone H3 lysine 27 methyltransferase enhancer of zeste homolog 2 (EZH2) is highly expressed in GC B cells and is often constitutively activated in GC-derived non-..
  58. doi Ezh2 regulates adult hippocampal neurogenesis and memory
    Juan Zhang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China, University of Chinese Academy of Sciences, Beijing 100049, China, and Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Neurosci 34:5184-99. 2014
    ..As the methyltransferase of histone H3K27, the role of Ezh2 in neurogenesis of adult mice and its mechanism of action are largely unknown...
  59. pmc Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA
    Chen Davidovich
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado, Boulder, CO 80309, USA
    Mol Cell 57:552-8. 2015
    ..We conclude that promiscuous and specific RNA-binding activities of PRC2 in vitro are not mutually exclusive, and that binding specificity in vivo remains to be demonstrated...
  60. pmc Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation
    Jianmin Zhang
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, United States
    Dev Biol 403:128-38. 2015
    ..in mouse, there are dynamic patterns of expression of the polycomb repressive complex 2 (PRC2) catalytic subunit EZH2 in retinal progenitors and some differentiated cells, as well as dynamic changes in the histone modification ..
  61. pmc Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation
    Nathan D Montgomery
    Department of Genetics, University of North Carolina at Chapel Hill, 103 Mason Farm Road, CB 7264, Chapel Hill, NC 27599 7264, USA
    J Mol Biol 374:1145-57. 2007
    ..complex, is composed of several proteins, including the histone H3 lysine 27 (H3K27) methyltransferase enhancer of zeste homolog 2 and the WD-repeat protein embryonic ectoderm development (EED)...
  62. pmc Jarid2 regulates mouse epidermal stem cell activation and differentiation
    Stefania Mejetta
    Department of Differentiation and Cancer, Center for Genomic Regulation and UPF, Barcelona, Spain
    EMBO J 30:3635-46. 2011
    ..We conclude that Jarid2 is required for the scheduled proliferation of epidermal stem and progenitor cells necessary to maintain epidermal homeostasis...
  63. pmc Polycomb repressive complex 2 targets murine cytomegalovirus chromatin for modification and associates with viral replication centers
    Christopher G Abraham
    Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 7:e29410. 2012
    ..Together, our results suggest a novel, dynamic interaction between PcG epigenetic repressors and MCMV genomes...
  64. pmc The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity
    Nicole A Rapicavoli
    Department of Neuroscience, Neurology and Ophthalmology, Center for High Throughput Biology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neural Dev 6:32. 2011
    ..Thousands of different long non-coding RNAs are expressed during embryonic development, but the function of these molecules remains largely unexplored...
  65. pmc Global gene expression analysis of very small embryonic-like stem cells reveals that the Ezh2-dependent bivalent domain mechanism contributes to their pluripotent state
    Dong Myung Shin
    Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Stem Cells Dev 21:1639-52. 2012
    ..in protein turnover and mitogenic pathways, and (iv) highly express enhancer of zeste drosophila homolog 2 (Ezh2), a polycomb group protein...
  66. pmc Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
    Heather M O'Hagan
    Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Cell 20:606-19. 2011
    ..Thus, oxidative damage induces formation and relocalization of a silencing complex that may explain cancer-specific aberrant DNA methylation and transcriptional silencing...
  67. pmc Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival
    Li Chen
    Department of Stem Cell Engineering, Basic Research Laboratories, Texas Heart Institute, Houston, Texas, United States of America
    PLoS ONE 7:e31005. 2012
    b>Ezh2 is a histone trimethyltransferase that silences genes mainly via catalyzing trimethylation of histone 3 lysine 27 (H3K27Me3)...
  68. pmc Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis
    Chang Ching Yang
    Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, Taiwan, ROC
    EMBO J 31:1739-51. 2012
    ....
  69. pmc A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
    Camille Simon
    The Leucegene Group, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3T 1J4, Canada
    Genes Dev 26:651-6. 2012
    ..frequency of spontaneous γδ T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion of enhancer of zeste homolog 2 (Ezh2). Tumor cells show little residual H3K27 trimethylation marks compared with controls...
  70. pmc Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells
    B A French
    Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Exp Mol Pathol 92:318-26. 2012
    b>EZH2/H3K27me3 and polycomb group complex (PcG) play a major role in regulating global gene expression including tumor suppressor genes...
  71. pmc Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations
    Stefan F Pinter
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Genome Res 22:1864-76. 2012
    ..This suggests that PRC2 and H3K27 methylation spread along a gradient unique to XCI. We propose that XCI is governed by a hierarchy of defined Polycomb stations that spread H3K27 methylation in cis...
  72. doi EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex
    Ji Min Lee
    Department of Biological Sciences, Creative Research Initiatives Center for Chromatin Dynamics, Seoul National University, Seoul 151 742, South Korea
    Mol Cell 48:572-86. 2012
    ..Further, we discovered that enhancer of zeste homolog 2 (EZH2) methyltransferase has distinct substrate specificities for histone H3K27 and nonhistones ..
  73. pmc Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    Wei Qi
    China Novartis Institutes for BioMedical Research, Shanghai 201203, China
    Proc Natl Acad Sci U S A 109:21360-5. 2012
    Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation and ..
  74. doi PRC1 coordinates timing of sexual differentiation of female primordial germ cells
    Shihori Yokobayashi
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 495:236-40. 2013
    ..These data demonstrate the importance of PRC1 gene dosage in PGC development and in coordinating the timing of sex differentiation of female PGCs by antagonizing extrinsic retinoic acid signalling...
  75. ncbi Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon
    S Shirasawa
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Med 3:646-50. 1997
    ..These results suggest that Enx is required for the proper positional specification and differentiative cell fate of enteric neurons...
  76. ncbi Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2
    M Ogawa
    Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
    Biochim Biophys Acta 1395:151-8. 1998
    ..A cell line of mouse neuroblastoma, Neuro-2a, also expresses Enx-2 mRNA and its level is elevated by induction of neuronal differentiation of the cell...
  77. pmc Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes
    M van Lohuizen
    Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 18:3572-9. 1998
    ..However, partial colocalization of Enx1 and Mph1 to subnuclear domains may point to more transient interactions between these complexes, in support of a bridging role for Enx1...
  78. ncbi The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6
    G Laible
    Research Institute of Molecular Pathology IMP The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Mamm Genome 10:311-4. 1999
  79. ncbi Xenopus Enhancer of Zeste (XEZ); an anteriorly restricted polycomb gene with a role in neural patterning
    M W Barnett
    Cell and Molecular Development Group, Department of Biological Sciences, University of Warwick, CV4 7AL, Coventry, UK
    Mech Dev 102:157-67. 2001
    ..Conversely, XEZ does not repress the forebrain marker Otx-2. XEZ overexpression results in a greatly thickened floor of the forebrain. These results implicate an important role for XEZ in the patterning of the nervous system...
  80. ncbi Epigenetic dynamics of imprinted X inactivation during early mouse development
    Ikuhiro Okamoto
    CNRS UMR218, Curie Institute, 26 Rue d Ulm, Paris 75005, France
    Science 303:644-9. 2004
    ..This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo...
  81. ncbi A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner
    Claire Attwooll
    European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, Milan, 20141, Italy
    J Biol Chem 280:1199-208. 2005
    ..Furthermore, we identified the proliferation-specific PcG, EZH2, as an EPC1-interacting protein...
  82. ncbi X chromosome reactivation and regulation in cloned embryos
    Leisha D Nolen
    Department of Cell and Developmental Biology, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104 6148, USA
    Dev Biol 279:525-40. 2005
    ..We conclude that, although SCNT embryos can reactivate, count, and inactivate X chromosomes, they are not able to regulate XCI consistently. These results illustrate the heterogeneity of epigenetic changes found in cloned embryos...
  83. ncbi EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells
    Madoka Koyanagi
    Department of Immunology, University of Washington, Seattle, Washington 98195 7650, USA
    J Biol Chem 280:31470-7. 2005
    ..and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 ..
  84. ncbi The polycomb group protein EZH2 is required for mammalian circadian clock function
    Jean Pierre Etchegaray
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, 01605, USA
    J Biol Chem 281:21209-15. 2006
    ..Endogenous EZH2, a polycomb group enzyme that methylates lysine 27 on histone H3, co-immunoprecipitates with CLOCK and BMAL1 ..
  85. ncbi Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
    Jindan Yu
    Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 12:419-31. 2007
    The Polycomb group (PcG) protein EZH2 possesses oncogenic properties for which the underlying mechanism is unclear. We integrated in vitro cell line, in vivo tumor profiling, and genome-wide location data to nominate key targets of EZH2...
  86. doi PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos
    Mareike Puschendorf
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Genet 40:411-20. 2008
    ..Here we demonstrate Ezh2-independent targeting of maternally provided polycomb repressive complex 1 (PRC1) components to paternal ..
  87. pmc Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity
    Ian J Majewski
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Biol 6:e93. 2008
    ..These data suggest that PRC2 is required to maintain a specific gene expression pattern in hematopoiesis that is indispensable to normal stem cell function...
  88. doi Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube
    Xavier Miro
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen D 37077, Germany
    Dis Model Mech 2:412-8. 2009
    ..Our work strongly suggests that brain malformations such as CM can result from altered epigenetic regulation of genes involved in cell proliferation in the brain...
  89. pmc Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes
    Tanya Shaw
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    EMBO Rep 10:881-6. 2009
    ..We show that PcGs Eed, Ezh2 and Suz12 are significantly downregulated during murine skin repair, whereas the newly described demethylases Jmjd3 ..
  90. pmc BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
    Julian Puppe
    Molecular Genetics and Cancer Genomics Centre, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Breast Cancer Res 11:R63. 2009
    ..Breast cancer 1 gene (BRCA1)-deficient tumors are usually of the basal subtype and associated with poor survival rates, highlighting the need for more effective therapy...
  91. ncbi Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation
    Margaret Rush
    Department of Medical Genetics, Life Sciences Institute, The University of British Columbia, Vancouver, BC, CA
    Epigenetics 4:404-14. 2009
    ..An interaction between EZH2 of the Polycomb repressive complex 2 (PRC2), which trimethylates lysine 27 on Histone 3 (H3K27me3), and all three ..
  92. pmc Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells
    Aster H Juan
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 36:61-74. 2009
    ..Once transcribed, miR-214 negatively feeds back on PcG by targeting the Ezh2 3'UTR, the catalytic subunit of the PRC2 complex...
  93. pmc MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis
    Jelena Mann
    Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    Gastroenterology 138:705-14, 714.e1-4. 2010
    ..The peroxisome proliferator-activated receptor gamma (PPARgamma) is a negative regulator of this process. We investigated epigenetic regulation of PPARgamma and myofibroblast transdifferentiation...
  94. pmc Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex
    Anne Schaefer
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 64:678-91. 2009
    ....
  95. pmc Dynamic patterns of histone lysine methylation in the developing retina
    Rajesh C Rao
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 51:6784-92. 2010
    ..To study the roles of HKM in retinogenesis, the authors examined the dynamic changes of three HKM modifications and of two of their regulators, the histone methyltransferases (HMTases) Ezh2 and G9a, in the mouse retina.
  96. pmc Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation
    BORIS G WILSON
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
    Cancer Cell 18:316-28. 2010
    ..Mechanistically, we show that loss of the SNF5 tumor suppressor leads to elevated expression of the Polycomb gene EZH2 and that Polycomb targets are broadly H3K27-trimethylated and repressed in SNF5-deficient fibroblasts and cancers...
  97. doi The expression pattern of polycomb group protein Ezh2 during mouse embryogenesis
    Zhu Ningxia
    Department of Histology and Embryology, Medical College of Shantou University, Guangdong Province, People s Republic of China
    Anat Rec (Hoboken) 294:1150-7. 2011
    ..Among them, the mammalian enhancer zeste homologue 2 (Ezh2) contributes to the transcriptional repression of these genes...
  98. doi The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines
    Reut Hod-Dvorai
    Department of Immunology, Technion Israel Institute of Technology, Haifa, Israel
    Eur J Immunol 41:2424-35. 2011
    ..show that in Th17 cells, the more phenotypically flexible Th lineage, the PcG proteins Mel-18 and less strikingly Ezh2 are associated differentially with the Il17a promoter...
  99. pmc Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells
    Alexandros Tzatsos
    Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:33061-9. 2011
    ..a program in which this chromatin-modifying enzyme counteracts the senescence-associated down-regulation of the EZH2 histone methyltransferase...
  100. pmc In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer
    Leo F Doherty
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Horm Cancer 1:146-55. 2010
    ..b>Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that has been linked to breast cancer risk and epigenetic ..
  101. pmc PDGF signalling controls age-dependent proliferation in pancreatic β-cells
    Hainan Chen
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 478:349-55. 2011
    ..With age, declining β-cell Pdgfr levels were accompanied by reductions in β-cell enhancer of zeste homologue 2 (Ezh2) levels and β-cell replication...

Research Grants1

  1. LIPID PEROXIDATION IN ALCOHOLIC LIVER DISEASE
    Samuel William French; Fiscal Year: 2010
    ..If this approach determines [how] ethanol-induces proteasomal inhibition, then a new mechanism of ethanol-induced liver injury will have been established which could provide a target for therapeutic intervention. ..