Evi5

Summary

Gene Symbol: Evi5
Description: ecotropic viral integration site 5
Alias: NB4S, ecotropic viral integration site 5 protein, EVI-5
Species: mouse

Top Publications

  1. pmc Evi-5, a common site of retroviral integration in AKXD T-cell lymphomas, maps near Gfi-1 on mouse chromosome 5
    X Liao
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Virol 69:7132-7. 1995
  2. pmc MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene
    T Schmidt
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Essen, Germany
    Nucleic Acids Res 24:2528-34. 1996
  3. pmc Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice
    B Scheijen
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    J Virol 71:9-16. 1997
  4. pmc GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas
    Beverly W Baron
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA Electronic address
    Blood Cells Mol Dis 52:68-75. 2014
  5. ncbi Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
    T Nakamura
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Nat Genet 12:149-53. 1996
  6. ncbi Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins
    X Liao
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Oncogene 14:1023-9. 1997
  7. ncbi A new region of synteny between human chromosome 1p22 and mouse chromosome 5
    D M Chelsea
    Center for Molecular Genetics NB20, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Int J Mol Med 5:553-6. 2000
  8. ncbi Candidate genes and their regulatory elements: alcohol preference and tolerance
    Laura Saba
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Mamm Genome 17:669-88. 2006
  9. pmc Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis
    Bindya Jacob
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore
    Blood 115:1610-20. 2010

Scientific Experts

  • Beverly W Baron
  • Bindya Jacob
  • Laura Saba
  • Juraj Bies
  • Loren Joseph
  • Joseph M Baron
  • Poluru L Reddy
  • Michael J Thirman
  • X Liao
  • Linda Wolff
  • John Anastasi
  • Kristen Wroblewski
  • Yoshiaki Ito
  • Dan R Littman
  • Chelsia Qiuxia Wang
  • D M Chelsea
  • Namiko Yamashita
  • Norio Asou
  • Motomi Osato
  • Ichiro Taniuchi
  • N G Copeland
  • N A Jenkins
  • Nicholas Grahame
  • Paula L Hoffman
  • Boris Tabakoff
  • John Belknap
  • Razvan Lapadat
  • Paula Bice
  • Sanjiv V Bhave
  • B Scheijen
  • T Schmidt
  • T Nakamura
  • T Roberts
  • J K Cowell
  • A Berns
  • H C Morse
  • Y Du
  • D Acton
  • J Jonkers
  • T Moroy
  • M Zörnig
  • D A Largaespada
  • J D Shaughnessy
  • R Beneke
  • A M Buchberg

Detail Information

Publications9

  1. pmc Evi-5, a common site of retroviral integration in AKXD T-cell lymphomas, maps near Gfi-1 on mouse chromosome 5
    X Liao
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Virol 69:7132-7. 1995
    ..These results are consistent with the hypothesis that T-cell lymphomagenesis is a multistep disease and that viral integration at Evi-5 or Gfi-1 is causally associated with this disease process...
  2. pmc MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene
    T Schmidt
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Essen, Germany
    Nucleic Acids Res 24:2528-34. 1996
    ....
  3. pmc Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice
    B Scheijen
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    J Virol 71:9-16. 1997
    ..This finding suggests that Bmi-1 and Gfi-1 belong to the same complementation group in lymphoid transformation...
  4. pmc GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas
    Beverly W Baron
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA Electronic address
    Blood Cells Mol Dis 52:68-75. 2014
    ..We now report three newly identified cooperating genes-GFI1B, EVI5, and MYB-that we identified in the lymphomas of retroviral-injected BCL6 transgenic mice (but not in retroviral-..
  5. ncbi Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
    T Nakamura
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Nat Genet 12:149-53. 1996
    ..These studies provide the first genetic evidence that Pbx1-related genes cooperate with Hox genes in leukaemia formation and identify a number of new murine myeloid leukaemia genes...
  6. ncbi Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins
    X Liao
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Oncogene 14:1023-9. 1997
    b>Evi5 is a common site of retroviral integration in T-cell lymphomas of AKXD mice...
  7. ncbi A new region of synteny between human chromosome 1p22 and mouse chromosome 5
    D M Chelsea
    Center for Molecular Genetics NB20, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Int J Mol Med 5:553-6. 2000
    ..the p22 region of human chromosome 1 we have been able to show the relative orientation of four genes; GFI1, NB4S/EVI5, RPL5 and DR1...
  8. ncbi Candidate genes and their regulatory elements: alcohol preference and tolerance
    Laura Saba
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Mamm Genome 17:669-88. 2006
    ....
  9. pmc Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis
    Bindya Jacob
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore
    Blood 115:1610-20. 2010
    ..Retroviral insertional mutagenesis revealed Evi5 activation as a cooperating genetic alteration and EVI5 overexpression indeed prevented Runx1(-/-) HSC exhaustion ..