Esr2

Summary

Gene Symbol: Esr2
Description: estrogen receptor 2 (beta)
Alias: ER[b], ERbeta, Estrb, estrogen receptor beta, ER-beta, nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta
Species: mouse

Top Publications

  1. ncbi Estrogen receptor specificity in the regulation of the skeleton in female mice
    M K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    J Endocrinol 171:229-36. 2001
  2. pmc Disruption of estrogen receptor beta gene impairs spatial learning in female mice
    Emilie F Rissman
    Department of Biology and Internal Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 99:3996-4001. 2002
  3. ncbi Localization of androgen and estrogen receptors in adult male mouse reproductive tract
    Qing Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    J Androl 23:870-81. 2002
  4. ncbi Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice
    A S Chagin
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    J Bone Miner Res 19:72-7. 2004
  5. pmc Kupffer cells and their mediators: the culprits in producing distant organ damage after trauma-hemorrhage
    Frank Hildebrand
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Volker Hall G094, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Am J Pathol 169:784-94. 2006
  6. pmc Ovarian wedge resection restores fertility in estrogen receptor beta knockout (ERbeta-/-) mice
    Jose Inzunza
    Division of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska University Hospital, Karolinska Institutet, Novum, S 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:600-5. 2007
  7. doi Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERα cross talk
    Elaine Emmerson
    The Healing Foundation Centre, The University of Manchester, Manchester, UK
    J Invest Dermatol 132:2838-48. 2012
  8. pmc The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice
    C Pendaries
    Institut National de la Santé et de la Recherche Médicale U397 et Laboratoire de Physiologie, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, 31054 Toulouse, France
    Proc Natl Acad Sci U S A 99:2205-10. 2002
  9. pmc Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Am J Pathol 164:1915-24. 2004
  10. ncbi Direct action of estradiol on gonadotropin-releasing hormone-1 neuronal activity via a transcription-dependent mechanism
    Jennifer L Temple
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:6326-33. 2004

Research Grants

  1. REMEDIATION OF EMPHYSEMA--MECHANISMS, CHARACTERISTICS
    Donald Massaro; Fiscal Year: 2001
  2. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
  3. EXPERIMENTAL EMPHYSEMA--STUDIES ON REMEDIATION
    Donald Massaro; Fiscal Year: 2001
  4. Alveolar Biology: Sex, Age, and Alveolar Turnover
    Donald Massaro; Fiscal Year: 2007
  5. Reproduction, Nutrition and Behavior
    EMILIE RISSMAN; Fiscal Year: 2008
  6. Testosterone in TNFR1 Signaling During Acute Myocardial Injury
    Meijing Wang; Fiscal Year: 2008
  7. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
  8. BEHAVIORAL REGULATION OF NEUROENDOCRINE CELLS
    EMILIE RISSMAN; Fiscal Year: 2005
  9. Tooth Eruption: Role of Dental Follicle & PTH Receptor
    Laurie McCauley; Fiscal Year: 2006
  10. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2009

Detail Information

Publications127 found, 100 shown here

  1. ncbi Estrogen receptor specificity in the regulation of the skeleton in female mice
    M K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    J Endocrinol 171:229-36. 2001
    There are two known estrogen receptors, estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta), which may mediate the actions of estrogen...
  2. pmc Disruption of estrogen receptor beta gene impairs spatial learning in female mice
    Emilie F Rissman
    Department of Biology and Internal Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 99:3996-4001. 2002
    ..evidence, to our knowledge, that estradiol (E(2)) affects learning and memory via the newly discovered estrogen receptor beta (ERbeta)...
  3. ncbi Localization of androgen and estrogen receptors in adult male mouse reproductive tract
    Qing Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    J Androl 23:870-81. 2002
    ..In this study, androgen receptor (AR) and estrogen receptors ERalpha and ERbeta were visualized by immunohistochemistry in adult male mice reproductive tracts, including testes, efferent ..
  4. ncbi Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice
    A S Chagin
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    J Bone Miner Res 19:72-7. 2004
    To determine the long-term role of ER beta in the regulation of longitudinal bone growth, appendicular and axial skeletal growth was followed and compared in female ER beta-/-, ER alpha-/-, and ER alpha-/- beta-/- mice...
  5. pmc Kupffer cells and their mediators: the culprits in producing distant organ damage after trauma-hemorrhage
    Frank Hildebrand
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Volker Hall G094, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Am J Pathol 169:784-94. 2006
    ..These findings suggest that Kupffer cell-derived MCP-1 plays a major role in remote organ dysfunction after trauma-hemorrhage...
  6. pmc Ovarian wedge resection restores fertility in estrogen receptor beta knockout (ERbeta-/-) mice
    Jose Inzunza
    Division of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska University Hospital, Karolinska Institutet, Novum, S 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:600-5. 2007
    Ovulation rarely occurs in mice in which the estrogen receptor beta (ERbeta) gene has been inactivated (ERbeta-/- mice)...
  7. doi Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERα cross talk
    Elaine Emmerson
    The Healing Foundation Centre, The University of Manchester, Manchester, UK
    J Invest Dermatol 132:2838-48. 2012
    ..The fact that IGF-1 may compensate for estrogen deficiency in wound repair, and potentially other contexts, is an important consideration for the treatment of postmenopausal pathology...
  8. pmc The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice
    C Pendaries
    Institut National de la Santé et de la Recherche Médicale U397 et Laboratoire de Physiologie, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, 31054 Toulouse, France
    Proc Natl Acad Sci U S A 99:2205-10. 2002
    Two isoforms of estrogen receptor (ER) have been described: ERalpha and ERbeta. The initial gene targeting of ERalpha, consisting in the introduction of a Neo cassette in exon 1 [alphaERKO, hereafter called ERalpha-Neo KO (knockout)], was ..
  9. pmc Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Am J Pathol 164:1915-24. 2004
    ..In contrast, the disease course in B10.PL/SnJ male mice with a disrupted estrogen receptor-2 (beta) gene (Esr2(-/-)) does not differ from that of wild-type (Esr2(+/+)) mice...
  10. ncbi Direct action of estradiol on gonadotropin-releasing hormone-1 neuronal activity via a transcription-dependent mechanism
    Jennifer L Temple
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:6326-33. 2004
    ..BSA (which does not cross the plasma membrane), or seen at 21 div, when the percentage of GnRH-1 cells expressing ERbeta transcripts declines...
  11. ncbi Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe
    Chrisana Gundlah
    Synaptic Pharmaceutical Corporation, Paramus
    Biol Psychiatry 57:938-42. 2005
    ..Tryptophan hydroxylase (TPH) is abundantly expressed in the serotonergic neurons of the DRN and is regulated by estrogen in both the monkey and the guinea pig...
  12. ncbi A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction
    J Ignacio Aguirre
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, The Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 282:25501-8. 2007
    ..the adaptive response of bone to mechanical forces is defective in mice lacking estrogen receptor (ER) alpha or ERbeta. We report that ERKs are not activated by stretching in osteocytic and osteoblastic cells in which both ERalpha ..
  13. ncbi Presence of estrogen receptor beta in urocortin 1-neurons in the mouse non-preganglionic Edinger-Westphal nucleus
    Nicole M Derks
    Department of Cellular Animal Physiology, Integrative Physiology, EURON Graduate School for Neuroscience, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Gen Comp Endocrinol 153:228-34. 2007
    ..nucleus (npEW), moderate immunostaining of the estrogen receptor alpha (ERalpha) was demonstrated, whereas estrogen receptor beta (ERbeta) was found to be more abundant...
  14. ncbi Expression of the estrogen-related receptor 1 (ERR-1) orphan receptor during mouse development
    E Bonnelye
    CNRS UMR 319, Mécanismes du Développement et de la Cancérisation, Institut de Biologie de Lille, France
    Mech Dev 65:71-85. 1997
    ..Interestingly, in these various systems ERR-1 expression is correlated with post-mitotic cells stage, suggesting that ERR-1 may play a role in the differentiation process...
  15. ncbi Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)
    Magdalena J Polanczyk
    Neuroimmunology Research, Veterans Affairs Medical Center, R and D 31, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Int Immunol 19:337-43. 2007
    ..These data clearly demonstrate that E2 can affect multiple regulatory elements that influence Treg suppression, including both PD-1-dependent and PD-1-independent pathways...
  16. ncbi Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
    K Paech
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
    Science 277:1508-10. 1997
    The transactivation properties of the two estrogen receptors, ERalpha and ERbeta, were examined with different ligands in the context of an estrogen response element and an AP1 element...
  17. ncbi Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha
    K Pettersson
    Department of Medical Nutrition and Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Mol Endocrinol 11:1486-96. 1997
    ..Here we report on the cloning of the cDNA encoding the mouse homolog of estrogen receptor-beta (ER beta) and the functional characterization of mouse ER beta protein...
  18. pmc Generation and reproductive phenotypes of mice lacking estrogen receptor beta
    J H Krege
    Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 95:15677-82. 1998
    ..Here we describe the generation of mice lacking estrogen receptor beta (ERbeta -/-) by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous ..
  19. ncbi Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1
    A Tremblay
    Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec, Canada
    Mol Cell 3:513-9. 1999
    ..of AF-1 by MAP kinase (MAPK) leads to the recruitment of steroid receptor coactivator-1 (SRC-1) by ER beta in vitro...
  20. ncbi Estrogen receptor null mice: what have we learned and where will they lead us?
    J F Couse
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 20:358-417. 1999
    ..abstract truncated]..
  21. ncbi Expression of estrogen receptor beta is developmentally regulated in reproductive tissues of male and female mice
    W N Jefferson
    Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 62:310-7. 2000
    ..assay (RPA) combined with immunohistochemical techniques, the expression of estrogen receptor (ER) alpha and ERbeta was mapped in the developing gonads and reproductive tracts of male and female mice from fetal day 14 to postnatal ..
  22. pmc Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus
    Z Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 97:5936-41. 2000
    ..Because of the poor reproductive capacity of ERbeta knockout (BERKO) female mice (small litter size, multiple-resorbed fetuses), the role of uterine ERbeta was ..
  23. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    ..ERs) in mouse ovary and genital tracts were investigated by generating null mutants for ERalpha (ERalphaKO), ERbeta (ERbetaKO) and both ERs (ERalphabetaKO)...
  24. ncbi Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice
    C Ohlsson
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, S 41345, Sweden
    Biochem Biophys Res Commun 278:640-5. 2000
    ..Total body fat content and serum levels of leptin were followed in ERalpha knockout (ERKO), ERbeta knockout (BERKO), and ERalpha/beta double knockout (DERKO) mice...
  25. pmc Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO)
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:14737-41. 2000
    ..Offensive attacks, on the other hand, depend specifically on the ER-alpha gene. Different patterns of natural behaviors require different patterns of functions by ER genes...
  26. ncbi Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss
    S H Windahl
    Department of Biosciences, Karolinska Institutet, Novum, Huddinge, Sweden
    J Bone Miner Res 16:1388-98. 2001
    Recently, it has been shown that inactivation of estrogen receptor beta (ER-beta) by gene targeting results in increased cortical bone formation in adolescent female mice...
  27. ncbi A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary
    Guojun Cheng
    Department of Medical Nutrition, Karolinska Institute, Novum, S 14186 Huddinge, Sweden
    Biol Reprod 66:77-84. 2002
    b>Estrogen receptor beta (ERbeta) is highly expressed, but ERalpha is not detectable in granulosa cells in the mouse ovary. In ERbeta knockout (BERKO) mice, there is abnormal follicular development and very reduced fertility...
  28. ncbi Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    N A Sims
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Bone 30:18-25. 2002
    To determine the contributions of estrogen receptor (ER)alpha and ERbeta in bone growth and remodeling in male and female mice, we generated and analyzed full knockouts for each receptor, and a double ER knockout...
  29. ncbi Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain
    Paul J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 143:1643-50. 2002
    ..The discovery of ERbeta suggested that binding was due to ERbeta, although questions about an ERgamma remained...
  30. ncbi Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the hair follicle cycling as well as the thickness of epidermis in male mice
    Sofia Moverare
    Department of Internal Medicine Division of Endocrinology, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    J Invest Dermatol 119:1053-8. 2002
    ..The aim of this study was to investigate the relative functional importance of estrogen receptor alpha and estrogen receptor beta in the regulation of the hair follicle cycling and epidermal thickness in male mice...
  31. ncbi Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice
    Marie K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    Mol Endocrinol 17:203-8. 2003
    ..The aim of the present study was to determine the role of estrogen receptor-beta (ERbeta) in vivo on global estrogen-regulated transcriptional activity in bone...
  32. ncbi Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta
    John F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:1039-53. 2003
    To determine the role of each estrogen receptor (ER) form (ERalpha, ERbeta) in mediating the estrogen actions necessary to maintain proper function of the hypothalamic-pituitary-gonadal axis, we have characterized the hypothalamic-..
  33. ncbi Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha
    Sudha Warrier Mitra
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Endocrinology 144:2055-67. 2003
    Estrogen receptor alpha (ER alpha) and ER beta are members of the steroid nuclear receptor family that modulate gene transcription in an estrogen-dependent manner...
  34. ncbi Transgenic models of metabolic bone disease: impact of estrogen receptor deficiency on skeletal metabolism
    L K McCauley
    Department of Periodontics, University of Michigan, Ann Arbor, Michigan, USA
    Connect Tissue Res 44:250-63. 2003
    ..Mechanisms for these effects and the selectivity to the estrogen receptor alpha (ER alpha) or ER beta are unclear...
  35. ncbi Double oestrogen receptor alpha and beta knockout mice reveal differences in neural oestrogen-mediated progestin receptor induction and female sexual behaviour
    A E Kudwa
    Neuroscience Graduate Program, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Neuroendocrinol 15:978-83. 2003
    To test the hypothesis that oestrogen receptor alpha (ERalpha) and ERbeta act together to mediate the actions of oestrogen in the ventromedial hypothalamus (VMH), we used mice with single or double knockout mutations of the ERalpha and ..
  36. pmc Brain masculinization requires androgen receptor function
    Takashi Sato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 101:1673-8. 2004
    ..Our results suggested that perinatal brain masculinization requires AR function and that expression of male-typical behaviors in adults is mediated by both AR-dependent and -independent androgen signaling...
  37. ncbi Estrogen receptor beta-mediated inhibition of male germ cell line development in mice by endogenous estrogens during perinatal life
    Geraldine Delbes
    Unité de Gamétogenèse et Génotoxicité, Institut National de la Sante et de la Recherche Medicale Unite 566, Commissariat a l Energie Atomique, Universite Paris 7 Denis Diderot, 92265 Fontenay aux Roses, France
    Endocrinology 145:3395-403. 2004
    ..The homozygous inactivation of ERbeta (ERbeta-/-) increased the number of gonocytes by 50% in 2- and 6-d-old neonates...
  38. pmc Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate
    Otabek Imamov
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:9375-80. 2004
    We have previously reported epithelial cellular hyperplasia in ventral prostates (VP) of mice lacking estrogen receptor beta (ER beta)...
  39. ncbi The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta
    K C L Lee
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    J Endocrinol 182:193-201. 2004
    ..in adult female mice lacking oestrogen receptor-alpha (ERalpha(-/-)), those lacking oestrogen receptor-beta (ERbeta(-/-)) and their wild-type littermates...
  40. ncbi Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling
    Ulrich Ohnemus
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Endocrinology 146:1214-25. 2005
    ..Between the two recognized estrogen receptors (ERs), ER alpha and ER beta, only ER alpha had been detected in murine skin...
  41. ncbi Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha
    Geraldine Delbes
    Unité de Gamétogenèse et Génotoxicité, Institut National de la Sante et de la Recherche Medicale Unite 566, Commissariat a l Energie Atomique, Universite Paris 7, Denis Diderot, Fontenay aux Roses, France
    Endocrinology 146:2454-61. 2005
    ..We previously reported that ER beta deficiency affects gametogenesis in mice but changes neither the number nor the differentiated functions of fetal ..
  42. ncbi In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation
    Judith M A Emmen
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 146:2817-26. 2005
    ..In this study, the role of ERalpha and ERbeta in folliculogenesis and ovulation was further analyzed...
  43. ncbi Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins
    John F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 146:3247-62. 2005
    ..gonadotropin-induced follicle growth, differentiation, and rupture, we characterized the response of ERalpha- and ERbeta-null mice to gonadotropin-induced ovulation...
  44. ncbi Both estrogen receptor-alpha and -beta are required for sexual differentiation of the anteroventral periventricular area in mice
    Cristian Bodo
    Program in Neuroscience C B, A E K, E F R, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 147:415-20. 2006
    ..In this series of experiments, the contributions of the two estrogen receptors (ERs), ERalpha and ERbeta, to the differentiation of the sexually dimorphic subpopulation of dopaminergic neurons in the anteroventral ..
  45. pmc Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha
    Rodrigo P A Barros
    Department of Biosciences and Nutrition, Karolinska Institute, S 141 86 Novum, Sweden
    Proc Natl Acad Sci U S A 103:1605-8. 2006
    ..In the present study, we investigated the expression of the two estrogen receptors, ERalpha and ERbeta, and their influence on regulation of the glucose transporter, GLUT4, and its associated structural protein, ..
  46. ncbi Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver
    G Bryzgalova
    Department of Molecular Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Diabetologia 49:588-97. 2006
    We used oestrogen receptor-alpha (ERalpha) knockout (ERKO) and receptor-beta (ERbeta) knockout (BERKO) mice to investigate the mechanism(s) behind the effects of oestrogens on glucose homeostasis.
  47. pmc Role of estrogen receptor beta in colonic epithelium
    Osamu Wada-Hiraike
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 103:2959-64. 2006
    ..To better understand the physiological role of ERbeta in colonic tissue, we have compared morphology, proliferation, and differentiation of colonic epithelium in ERbeta-..
  48. pmc Functional estrogen receptors in the mitochondria of breast cancer cells
    Ali Pedram
    Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, Long Beach, CA 90822, USA
    Mol Biol Cell 17:2125-37. 2006
    ..of MCF-7 breast cancer cells and endothelial cells, compatible with classical estrogen receptors ERalpha and ERbeta. We report that in MCF-7, estrogen inhibits UV radiation-induced cytochrome C release, the decrease of the ..
  49. pmc Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice
    Andrea Morani
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 103:7165-9. 2006
    b>Estrogen receptor beta (ERbeta) is highly expressed in both type I and II pneumocytes as well as bronchiolar epithelial cells. ERalpha is not detectable in the adult lung...
  50. ncbi Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia
    Stephen J McPherson
    Centre for Urological Research, Monash Institute of Medical Research, Monash University, Clayton 3168, Australia
    Endocrinology 148:566-74. 2007
    ..Previous studies using animal models to determine the role of ERbeta in the prostate have been problematic because the centrally mediated response to estrogen results in reduced ..
  51. ncbi New developments in oestrogen signalling in colonic epithelium
    O Wada-Hiraike
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE 141 86 Stockholm, Sweden
    Biochem Soc Trans 34:1114-6. 2006
    ..studies show that oestrogen reduces the risk of colorectal cancer in postmenopausal women and ERbeta (oestrogen receptor beta)-selective ligands have been reported to be very effective treatment in animal models of inflammatory ..
  52. ncbi The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta
    L K Saxon
    Department of Orthopaedic Surgery, Indiana University Purdue University, Indianapolis, USA
    Am J Physiol Endocrinol Metab 293:E484-91. 2007
    ..001). We conclude that estrogen signaling through ER-beta suppresses the mechanical loading response on the periosteal surface of long bones...
  53. pmc Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment
    Seema Tiwari-Woodruff
    Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, University of California, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:14813-8. 2007
    ..Here, we have contrasted effects of treatment with an ERalpha vs. an ERbeta ligand in experimental autoimmune encephalomyelitis, the multiple sclerosis model with a known pathogenic role for ..
  54. pmc GPR30 contributes to estrogen-induced thymic atrophy
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Mol Endocrinol 22:636-48. 2008
    ..receptor 30 (GPR30), and the intracellular estrogen receptors, estrogen receptor alpha (ERalpha) and beta (ERbeta), in 17beta-estradiol (E2)-induced thymic atrophy were distinguished by construction and the side-by-side ..
  55. pmc Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
    Susan A Krum
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    EMBO J 27:535-45. 2008
    ..These results demonstrate that estrogen protects bone by inducing a paracrine signal originating in osteoblasts leading to the death of pre-osteoclasts and offer an important new target for the prevention and treatment of osteoporosis...
  56. pmc Pancreatic insulin content regulation by the estrogen receptor ER alpha
    Paloma Alonso-Magdalena
    Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Alicante, Spain
    PLoS ONE 3:e2069. 2008
    ..Estrogen receptors, ER alpha and ER beta, are important molecules involved in glucose metabolism, yet their role in pancreatic beta-cell physiology is ..
  57. pmc Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma
    Anna Foryst-Ludwig
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS Genet 4:e1000108. 2008
    ..While ERalpha seems to have a protective role in such diseases, the function of ERbeta is not clear...
  58. pmc Estrogen receptor beta is required for optimal cAMP production in mouse granulosa cells
    Bonnie J Deroo
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 23:955-65. 2009
    ..have previously shown that FSH-mediated granulosa cell differentiation requires functional estrogen receptor-beta (ERbeta) by demonstrating that the granulosa cells of ERbeta(-/-) FSH-treated mice are unable to maximally induce ..
  59. doi Participation of ERalpha and ERbeta in glucose homeostasis in skeletal muscle and white adipose tissue
    Rodrigo P A Barros
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Sweden
    Am J Physiol Endocrinol Metab 297:E124-33. 2009
    ..In the present study, to investigate the relative contributions of ERalpha and ERbeta in glucose homeostasis, we examined the effects of tamoxifen (Tam) on GLUT4 expression in SM and WAT in wild-type (..
  60. pmc Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival
    Suhuan Liu
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University School of Medicine, Chicago, Illinois, USA
    Diabetes 58:2292-302. 2009
    ..E(2) also activates nongenomic signals via an extranuclear form of ERalpha and the G protein-coupled estrogen receptor (GPER). We studied the contribution of estrogen receptors to islet survival...
  61. doi Rapid regulation of K(ATP) channel activity by 17{beta}-estradiol in pancreatic {beta}-cells involves the estrogen receptor {beta} and the atrial natriuretic peptide receptor
    Sergi Soriano
    Institute of Bioengineering and CIBERDEM, Universidad Miguel Hernandez de Elche, Alicante, Spain
    Mol Endocrinol 23:1973-82. 2009
    ..K(ATP) channel was not modified in beta-cells from ERalpha-/- mice, yet it was significantly reduced in cells from ERbeta-/- mice. The effect of E2 was mimicked by the ERbeta agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN)...
  62. pmc Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated
    Stephen J McPherson
    Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:3123-8. 2010
    ..different to castration, this study shows beneficial proapoptotic actions of estrogen receptor-beta (ERbeta) in BPH and PCa...
  63. pmc Estrogen receptor-{beta}-selective ligands alleviate high-fat diet- and ovariectomy-induced obesity in mice
    Muralimohan Yepuru
    Preclinical Research and Development, GTx Inc, Memphis, Tennessee 38163, USA
    J Biol Chem 285:31292-303. 2010
    ..In conclusion, these studies indicate that ligand-activated ER-β is a potential therapeutic target to combat obesity and obesity-related metabolic diseases...
  64. pmc Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities
    Laura Campbell
    Faculty of Life Sciences, University of Manchester, Manchester, England, UK
    J Exp Med 207:1825-33. 2010
    ..modulates skin repair, particularly the cell type-specific role of the two estrogen receptors, ERalpha and ERbeta, has yet to be determined...
  65. pmc Estrogen receptor-beta prevents cardiac fibrosis
    Ali Pedram
    Medical Service 111 I, Department of Veterans Affairs Medical Center, 5901 East 7th Street, Long Beach, California 90822, USA
    Mol Endocrinol 24:2152-65. 2010
    ..Our results establish the cardiac fibroblast as an important target for hypertrophic/fibrosis-inducing peptides the actions of which were mitigated by E2/ERβ acting in these stromal cells...
  66. doi Estrogen receptor-β signaling modulates epithelial barrier function
    Mirjam Looijer-van Langen
    Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Physiol Gastrointest Liver Physiol 300:G621-6. 2011
    ..This study suggests a potential role for ERβ signaling in the modulation of epithelial permeability and demonstrates reduced ERβ mRNA in animal models of colitis and colon of patients with inflammatory bowel disease...
  67. doi Estrogen receptors α and β have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone
    L K Saxon
    The Royal Veterinary College, Royal College Street London, London NW1 OTU, United Kingdom
    Endocrinology 153:2254-66. 2012
    ..Bone loss due to disuse in cortical bone is unaffected by ER status, but in cancellous bone, functional ERα contributes to greater disuse-related bone loss...
  68. pmc Estrogen receptor-β protects against colitis-associated neoplasia in mice
    Diana Saleiro
    Cancer Biology Division, IIT Research Institute, Chicago, IL 60616, USA
    Int J Cancer 131:2553-61. 2012
    ..These results demonstrate for the first time that ERβ provides protection in the AOM/DSS-induced CAC model in mice, suggesting a preventive and/or therapeutic potential for the use of ERβ-selective agonists in IBD...
  69. pmc A role for estrogen receptor-α and estrogen receptor-β in collagen biosynthesis in mouse skin
    Margaret Markiewicz
    Medical University of South Carolina, Charleston, SC, USA
    J Invest Dermatol 133:120-7. 2013
    ..Together, these results demonstrate distinct functions of ERs in the regulation of collagen biosynthesis in mouse skin in vivo...
  70. pmc Increased mandibular condylar growth in mice with estrogen receptor beta deficiency
    Yosuke Kamiya
    Division of Orthodontics, Columbia University College of Dental Medicine, New York, NY 10032, USA
    J Bone Miner Res 28:1127-34. 2013
    ..In long bones, estrogen acting via estrogen receptor beta (ERβ) inhibits axial skeletal growth in female mice...
  71. doi Suppression of ERβ signaling via ERβ knockout or antagonist protects against bladder cancer development
    Iawen Hsu
    Department of Urology and
    Carcinogenesis 35:651-61. 2014
    ..rates than men, suggesting that estrogen and the estrogen receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), may play critical roles in BCa progression...
  72. ncbi Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus
    C S Rosenfeld
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Mol Reprod Dev 59:336-46. 2001
    ..The data obtained have confirmed some older inferences about how the steroid acts, but have also revealed some unexpected aspects of estrogen action. Mol. Reprod. Dev. 59:336-346, 2001...
  73. ncbi Mutations in the estrogen receptor DNA-binding domain discriminate between the classical mechanism of action and cross-talk with Stat5b and activating protein 1 (AP-1)
    Linda Björnström
    Department of Cell and Molecular Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Biol Chem 277:48479-83. 2002
    ..These findings provide new insights into the mechanisms by which ERs act in cross-talk with non-related transcription factors...
  74. pmc Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant
    Maria Cristina Antal
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, College de France, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Proc Natl Acad Sci U S A 105:2433-8. 2008
    Estrogen signaling is mediated by estrogen receptors alpha (ERalpha) and beta (ERbeta)...
  75. pmc Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma
    Katarzyna Urbanska
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 219:392-401. 2009
    ..Here we demonstrate for the first time that estrogen receptor beta (ERbeta) can contribute to the development of genomic instability in medulloblastomas...
  76. pmc Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
    O Vidal
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Proc Natl Acad Sci U S A 97:5474-9. 2000
    ..relative importance of ER subtypes in the regulation of the male skeleton was studied in ERalpha-knockout (ERKO), ERbeta-knockout (BERKO), and double ERalpha/beta-knockout (DERKO) mice...
  77. ncbi Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta
    G B Tremblay
    Molecular Oncology Group, Boyal Victoria Hospital Montréal, Quebec, Canada
    Mol Endocrinol 11:353-65. 1997
    b>Estrogen receptor beta (ER beta) is a novel steroid receptor that is expressed in rat prostate and ovary. We have cloned the mouse homolog of ER beta and mapped the gene, designated Estrb, to the central region of chromosome 12...
  78. pmc Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Nucleic Acids Res 26:3505-12. 1998
    ..Biochemical analysis reveals that the average dissociation constants ( K d) of ERalpha and ERbeta for 17beta-estradiol (E2) are 0.2 and 0.6 nM respectively, but ERbetacx has no ligand binding ability...
  79. ncbi Expression of estrogen receptor alpha and beta during mouse embryogenesis
    J G Lemmen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Mech Dev 81:163-7. 1999
    ..This is the first report on the expression of estrogen receptor beta (ERbeta) in comparison with ERalpha mRNA during mouse embryogenesis...
  80. ncbi Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 140:2613-20. 1999
    Estrogen receptor-1 (ER beta) messenger RNA (mRNA) has been detected in the brain of wild-type and estrogen receptor-alpha knockout (ER alphaKO) mice...
  81. ncbi Estradiol induces galanin gene expression in the pituitary of the mouse in an estrogen receptor alpha-dependent manner
    E S Shen
    Peptide Pharmacology Section, Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 140:2628-31. 1999
    ..We have utilized ER alpha-knock-out (ER alphaKO) mice to discriminate the roles of ER alpha and ER beta in the regulation of GAL gene expression in the anterior pituitary gland...
  82. ncbi Assignment of estrogen receptor beta (Esr2) to rat chromosome band 6q24 and (Estrb) to mouse chromosome band 12D1-D3 by in situ hybridization
    T Taguchi
    Department of Anatomy, Kochi Medical School, Kochi, Japan
    Cytogenet Cell Genet 86:233-4. 1999
  83. ncbi Ontogenetic expression and sex differences of aromatase and estrogen receptor-alpha/beta mRNA in the mouse hippocampus
    T Ivanova
    Abteilung Anatomie und Zellbiologie, Universitat Ulm, Germany
    Cell Tissue Res 300:231-7. 2000
    ..Thus, our data support the idea that the developing hippocampus is a target for estrogen action and estrogen receptor-mediated sexual differentiation...
  84. ncbi Stimulation of vascular protein synthesis by activation of oestrogen receptor beta
    M Liang
    Department of Physiological Sciences, Lund University, BMC F12, S 221 84 Lund, Sweden
    J Endocrinol 171:417-23. 2001
    ..Nuclear immunoreactivity towards ER beta was observed abundantly in vascular smooth muscle and endothelial cells of mouse aorta...
  85. ncbi Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos
    Andrés A Kowalski
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, Department of Animal Sciences, University of Florida, Gainesville, Florida 32611 0910, USA
    Biol Reprod 66:760-9. 2002
    ..These studies taken together suggest that embryonic ER-beta likely mediates the autocrine functions of estrogens in the dynamic regulation of embryonic growth and development at periimplantation...
  86. ncbi Estrogen-induced osteogenesis in intact female mice lacking ERbeta
    K E McDougall
    Academic Rheumatology, University of Bristol, Bristol BS2 8HW, United Kingdom
    Am J Physiol Endocrinol Metab 283:E817-23. 2002
    ..we studied the role of specific ER subtypes in this response by examining whether this is impaired in female ERbeta(-/-) mice previously generated by targeted gene deletion. Vehicle or 17beta-estradiol (E(2)) (range 4-4,000 microg...
  87. pmc An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth
    Zhang Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 99:13589-94. 2002
    ..We have used ERbeta(-/-) and CYP7B1(-/-) mice to investigate the role of ERbeta and one of its ligands, 5alpha-androstane-3beta,17beta-..
  88. pmc Characterization of the ERbeta-/-mouse heart
    Carola Förster
    Department of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:14234-9. 2004
    ..No role for estrogen receptor (ER) beta in the heart has been established, but ERbeta(-/-) mice are hypertensive, and as they age, their hearts become enlarged...
  89. ncbi Endogenous estrogen receptor beta is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice
    Stefan O Mueller
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Steroids 69:681-6. 2004
    ..Intriguingly, a clear and undisputed physiological function of the recently described ERbeta remains elusive, with the exception of the ovary where a cooperative role of ERalpha and ERbeta has been ..
  90. ncbi Gender-specific alteration of adrenergic responses in small femoral arteries from estrogen receptor-beta knockout mice
    Leonid Luksha
    Department of Obstetrics and Gynecology, Institution for Clinical Science, Intervention, and Technology CLINTEC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Hypertension 46:1163-8. 2005
    ..beta-adrenoceptor-mediated dilatation was also enhanced in estrogen receptor-beta knockout versus wild-type males. We suggest that estrogen receptor-beta modifies the adrenergic control of small artery tone in males but not in females...
  91. ncbi Knee ligament mechanical properties are not influenced by estrogen or its receptors
    Stuart J Warden
    Dept of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Am J Physiol Endocrinol Metab 290:E1034-40. 2006
    ..This study investigated the influence of estrogen and its receptors (ER alpha and ER beta) on knee ligament mechanical properties...
  92. ncbi Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction
    Hiromichi Hamada
    Division of Cardiovascular Research, St Elizabeth Medical Center of Boston, Tufts University School of Medicine, Boston, Mass, USA
    Circulation 114:2261-70. 2006
    ..However, the roles of estrogen receptors alpha (ER alpha) and beta (ER beta) in EPC biology are largely unknown.
  93. ncbi Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice
    Nancy L Cho
    Departments of Surgery and Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 67:2366-72. 2007
    ..of E(2) in intestinal tumor inhibition, we separately crossed C57BL/6J-Min/+ (Min/+) mice with Eralpha(+/-) and Erbeta(+/-) mice to generate ER-deficient Min/+ progeny...
  94. ncbi Role of estrogen receptors in neuroprotection by estradiol against MPTP toxicity
    Marc Morissette
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, Quebec City, QC, Canada
    Neuropharmacology 52:1509-20. 2007
    ..is thought to be mediated by an interaction with estrogen receptors (ER), of which there are two: ERalpha and ERbeta. In the present study, the role of these two ERs in MPTP toxicity and its neuroprotection by estradiol was ..
  95. ncbi Gender-specific effects of endogenous testosterone: female alpha-estrogen receptor-deficient C57Bl/6J mice develop glomerulosclerosis
    S J Elliot
    Department of Medicine, Study Group and Laboratory on Sex and Gender Differences in Health and Disease, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Kidney Int 72:464-72. 2007
    ..Estrogen deficiency had no deleterious effects on the glomeruli in B6 mice. Our study shows that genetic traits strongly influence the GS-promoting effects of estrogen deficiency while testosterone induces GS in a gender-specific manner...
  96. ncbi The effects of oestrogen receptors alpha and beta on testicular cell number and steroidogenesis in mice
    M L Gould
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    Reproduction 134:271-9. 2007
    ..This study used mice null for oestrogen receptor alpha (ER alpha) or beta (ER beta) to investigate which receptor mediates the effects of oestrogen within the testis...
  97. ncbi Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain
    M Morissette
    Molecular Endocrinology and Oncology Research Center, Medical Center and Faculty of Pharmacy, Laval University, 2705 Laurier Boulevard, Sainte Foy, Quebec, Canada
    J Steroid Biochem Mol Biol 108:327-38. 2008
    ..The estrogen receptors ERalpha and ERbeta are present in the brain and their targeting could bring selectivity and reduced risk of cancer...
  98. doi Genetic and pharmacologic strategies to determine the function of estrogen receptor alpha and estrogen receptor beta in cardiovascular system
    Paula Anahi Arias-Loza
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Gend Med 5:S34-45. 2008
    ....
  99. doi Oestrogen receptor beta contributes to the transient sex difference in tyrosine hydroxylase expression in the mouse locus coeruleus
    J S Pendergast
    Department of Neurological Surgery, The Miami Project to Cure Paralysis, Miller School of Medicine, Miami, FL, USA
    J Neuroendocrinol 20:1155-64. 2008
    ..studies reported conflicting results regarding ER protein expression in the mouse LC, we evaluated ER alpha and ER beta gene expression by in situ hybridisation and the real-time reverse transcription-polymerase chain reaction...
  100. doi Role of estrogen receptor-alpha and -beta in regulating leptin expression in 3T3-L1 adipocytes
    Kyong Wook Yi
    Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea
    Obesity (Silver Spring) 16:2393-9. 2008
    We investigated the effects of the estrogen receptor-alpha (ERalpha) and -beta (ERbeta) in the regulation of leptin, resistin, and adiponectin expression in 3T3-L1 adipocytes...
  101. doi Oestrogen receptor alpha and beta immunoreactive cells in the suprachiasmatic nucleus of mice: distribution, sex differences and regulation by gonadal hormones
    B Vida
    Department of Endocrine Neurobiology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroendocrinol 20:1270-7. 2008
    ..and neurochemical phenotype of neurones expressing the alpha and beta subtypes of oestrogen receptors (ERalpha and ERbeta) in the mouse SCN...

Research Grants17

  1. REMEDIATION OF EMPHYSEMA--MECHANISMS, CHARACTERISTICS
    Donald Massaro; Fiscal Year: 2001
    ....
  2. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..There is not treatment that slows the relentless progression of the disease or that reverses it. In this application, we use an animal model to investigate methods to slow progression and reverse the disease. ..
  3. EXPERIMENTAL EMPHYSEMA--STUDIES ON REMEDIATION
    Donald Massaro; Fiscal Year: 2001
    ....
  4. Alveolar Biology: Sex, Age, and Alveolar Turnover
    Donald Massaro; Fiscal Year: 2007
    ..Key new findings since the last submission are: 1. Adult female estrogen receptor (ER)alpha and ERbeta k.o. mice have an alveolar phenotype - larger and fewer alveoli with less surface area than wildtype mice. 2...
  5. Reproduction, Nutrition and Behavior
    EMILIE RISSMAN; Fiscal Year: 2008
    ..It is likely that this information will provide new approaches for the study of GnRH-II peptide in humans. Moreover, this work may provide insights into physiological bases of eating disorders. [unreadable] [unreadable]..
  6. Testosterone in TNFR1 Signaling During Acute Myocardial Injury
    Meijing Wang; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  7. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
    ....
  8. BEHAVIORAL REGULATION OF NEUROENDOCRINE CELLS
    EMILIE RISSMAN; Fiscal Year: 2005
    ..receptors in activation of sexual behavior the PI has obtained several additional KO mice; including the estrogen receptor beta knockout and Tfm mice (androgen receptor knockouts)...
  9. Tooth Eruption: Role of Dental Follicle & PTH Receptor
    Laurie McCauley; Fiscal Year: 2006
    ..Furthermore, these studies will enhance our basic knowledge as to the role of PTHrP and PTH-1R interactions in controlling mineralized tissue homeostasis. ..
  10. Microglia adenine nucleotides and hypoxia
    JYOTI WATTERS; Fiscal Year: 2009
    ..Results of this work will aid in the identification of new pharmacologic targets that may be exploited therapeutically to control microglial activation in response to several stimuli including hypoxia. ..
  11. ECM Regulation by Estrogen in ARMD
    Sharon Elliot; Fiscal Year: 2006
    ..Conversely, we expect that estrogen's antioxidant action on the cell membrane will diminish MPO-induced blebbing and that activation of estrogen receptors will modify matrix molecule dysregulation. ..
  12. Estrogen Receptor Gene Transfer in Mouse Brains
    Sonoko Ogawa; Fiscal Year: 2004
    ..The outcome of the proposed studies will provide valuable information about mechanisms of action of two types of ERs in the brain. ..
  13. EXERCISE SPECIFICITY FOR PHYSICAL FRAILTY
    Marybeth Brown; Fiscal Year: 2004
    ..3. Determine if the gains from each exercise program can be sustained for 3 months. ..
  14. ROLE OF ALPHA & BETA ESTROGEN RECEPTORS IN AGGRESSION
    Sonoko Ogawa; Fiscal Year: 2003
    ..The findings of the proposed studies will provide new insights concerning the specific roles and mechanisms played by the two types of ERs in the sex-specific regulation of aggressive behavior by gonadal steroids. ..
  15. PREHAB VS REHAB FOR REDUCING BEDREST EFFECTS WITH AGING
    Marybeth Brown; Fiscal Year: 2002
    ..If preliminary findings are confirmed, it would provide support for appropriate human studies, and for expansion of habilitation services to older adults to include both pre-habilitation and rehabilitation. ..
  16. Sex chromosome effects on neural and behavioral differentiation
    Emilie F Rissman; Fiscal Year: 2011
    ..The work will also enrich and inform our knowledge of sex differences in both normal and clinical populations. ..
  17. Development Estrogenization of the Rat Prostate Gland
    Gail S Prins; Fiscal Year: 2010
    ..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...