Esr1

Summary

Gene Symbol: Esr1
Description: estrogen receptor 1 (alpha)
Alias: ER-alpha, ERa, ERalpha, ESR, Estr, Estra, Nr3a1, estrogen receptor, estradiol receptor, nuclear receptor subfamily 3 group A member 1
Species: mouse

Top Publications

  1. ncbi Estrogen receptor null mice: what have we learned and where will they lead us?
    J F Couse
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 20:358-417. 1999
  2. pmc Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
    O Vidal
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Proc Natl Acad Sci U S A 97:5474-9. 2000
  3. ncbi Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta
    John F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:1039-53. 2003
  4. pmc Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Andrew Sunters
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    J Biol Chem 285:8743-58. 2010
  5. ncbi Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
    J F Couse
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 138:4613-21. 1997
  6. pmc Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities
    Laura Campbell
    Faculty of Life Sciences, University of Manchester, Manchester, England, UK
    J Exp Med 207:1825-33. 2010
  7. doi Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice
    Filip Callewaert
    Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 25:124-31. 2010
  8. ncbi In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation
    Judith M A Emmen
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 146:2817-26. 2005
  9. pmc Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
    Susan A Krum
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    EMBO J 27:535-45. 2008
  10. ncbi Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    N A Sims
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Bone 30:18-25. 2002

Research Grants

  1. REMEDIATION OF EMPHYSEMA--MECHANISMS, CHARACTERISTICS
    Donald Massaro; Fiscal Year: 2001
  2. EXPERIMENTAL EMPHYSEMA--STUDIES ON REMEDIATION
    Donald Massaro; Fiscal Year: 2001
  3. Alveolar Biology: Sex, Age, and Alveolar Turnover
    Donald Massaro; Fiscal Year: 2007
  4. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
  5. TISSUE INTERACTIONS AND HORMONAL RESPONSES IN THE UTERUS
    Robert Bigsby; Fiscal Year: 2004
  6. BEHAVIORAL REGULATION OF NEUROENDOCRINE CELLS
    EMILIE RISSMAN; Fiscal Year: 2005
  7. Endocrine Regulation of Hepatocellular Carcinogenesis
    Robert Bigsby; Fiscal Year: 2007
  8. Reproduction, Nutrition and Behavior
    EMILIE RISSMAN; Fiscal Year: 2008
  9. Sex chromosome effects on neural and behavioral differentiation
    Emilie F Rissman; Fiscal Year: 2011
  10. GENETIC MECHANISMS OF ESTROGEN ATHEROPROTECTION
    Amparo Villablanca; Fiscal Year: 2003

Detail Information

Publications210 found, 100 shown here

  1. ncbi Estrogen receptor null mice: what have we learned and where will they lead us?
    J F Couse
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 20:358-417. 1999
    ..have definitively illustrated several roles that were previously believed to be dependent on functional ER alpha, including 1) the proliferative and differentiative actions critical to the function of the adult female ..
  2. pmc Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
    O Vidal
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Proc Natl Acad Sci U S A 97:5474-9. 2000
    ..The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERalpha-knockout (ERKO), ERbeta-knockout (BERKO), and double ERalpha/beta-knockout (DERKO) mice...
  3. ncbi Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta
    John F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:1039-53. 2003
    To determine the role of each estrogen receptor (ER) form (ERalpha, ERbeta) in mediating the estrogen actions necessary to maintain proper function of the hypothalamic-pituitary-gonadal axis, we have characterized the hypothalamic-..
  4. pmc Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Andrew Sunters
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    J Biol Chem 285:8743-58. 2010
    ..Strain-related IGF-IR activation of AKT requires estrogen receptor alpha (ERalpha) with which IGF-1R physically associates...
  5. ncbi Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
    J F Couse
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 138:4613-21. 1997
    Until recently, only a single type of estrogen receptor (ER) was thought to exist and mediate the genomic effects of the hormone 17beta-estradiol in mammalian tissues...
  6. pmc Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities
    Laura Campbell
    Faculty of Life Sciences, University of Manchester, Manchester, England, UK
    J Exp Med 207:1825-33. 2010
    ..which estrogen modulates skin repair, particularly the cell type-specific role of the two estrogen receptors, ERalpha and ERbeta, has yet to be determined...
  7. doi Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice
    Filip Callewaert
    Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 25:124-31. 2010
    In female mice, estrogen receptor-alpha (ERalpha) mediates the anabolic response of bone to mechanical loading...
  8. ncbi In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation
    Judith M A Emmen
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 146:2817-26. 2005
    Both estrogen receptor (ER) alpha and beta are expressed within the ovary and lack of either of these receptors affects ovarian function...
  9. pmc Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
    Susan A Krum
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    EMBO J 27:535-45. 2008
    ..a cell-type-specific hormone-inducible enhancer located 86 kb downstream of the FasL gene as the target of estrogen receptor-alpha induction of FasL expression in osteoblasts...
  10. ncbi Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    N A Sims
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Bone 30:18-25. 2002
    To determine the contributions of estrogen receptor (ER)alpha and ERbeta in bone growth and remodeling in male and female mice, we generated and analyzed full knockouts for each receptor, and a double ER knockout...
  11. pmc The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol
    Audrey Billon-Gales
    Institut de Medecine Moleculaire de Rangueil, Institut National de la Sante et de la Recherche Medicale, Unité 858, Universite Toulouse III Paul Sabatier, Centre Hospitalier Universitaire de Toulouse, 31432 Toulouse, France
    Proc Natl Acad Sci U S A 106:2053-8. 2009
    Full-length 66-kDa estrogen receptor alpha (ERalpha) stimulates target gene transcription through two activation functions (AFs), AF-1 in the N-terminal domain and AF-2 in the ligand binding domain...
  12. doi Expression, distribution and regulation of sex steroid hormone receptors in mouse heart
    Eric Lizotte
    Research Center, Montreal Heart Institute, Montreal, Quebec
    Cell Physiol Biochem 23:75-86. 2009
    ..Western blot analysis and densitometry to characterize the subcellular distribution and abundance of estrogen receptor (ER) alpha, ERbeta and androgen receptor (AR) in atrial and ventricular tissue from male and female mice...
  13. pmc Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis
    Srimoyee Ghosh
    Department of Pathology, Harvard Medical School and Immune Disease Institute, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:15169-74. 2010
    ....
  14. pmc Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone
    A E Börjesson
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, S 41345 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 108:6288-93. 2011
    The bone-sparing effect of estrogen is primarily mediated via estrogen receptor-α (ERα), which stimulates target gene transcription through two activation functions (AFs), AF-1 in the N-terminal and AF-2 in the ligand binding domain...
  15. doi Estrogen receptors α and β have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone
    L K Saxon
    The Royal Veterinary College, Royal College Street London, London NW1 OTU, United Kingdom
    Endocrinology 153:2254-66. 2012
    ..Bone loss due to disuse in cortical bone is unaffected by ER status, but in cancellous bone, functional ERα contributes to greater disuse-related bone loss...
  16. doi Generation of ERα-floxed and knockout mice using the Cre/LoxP system
    P Antonson
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE 141 83 Huddinge, Sweden
    Biochem Biophys Res Commun 424:710-6. 2012
    b>Estrogen receptor alpha (ERα) is a nuclear receptor that regulates a range of physiological processes in response to estrogens...
  17. pmc Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2
    Sara H Windahl
    Department of Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Bone Miner Res 28:291-301. 2013
    b>Estrogen receptor-α (ERα) is crucial for the adaptive response of bone to loading but the role of endogenous estradiol (E2) for this response is unclear...
  18. pmc Increased adipose tissue in male and female estrogen receptor-alpha knockout mice
    P A Heine
    Departments of Veterinary Biosciences and Kinesiology, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 97:12729-34. 2000
    ..the amount of white adipose tissue (WAT) in females, but its role in males and whether WAT effects involve estrogen receptor-alpha (ERalpha) or ERbeta were unclear...
  19. ncbi Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha
    Stefan O Mueller
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 143:2357-65. 2002
    Complete mammary gland development takes place following puberty and depends on the estrogen receptor (ER)alpha and the progesterone receptor (PR) and is tightly regulated by the interaction of the mammary epithelium with the stromal ..
  20. ncbi Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the hair follicle cycling as well as the thickness of epidermis in male mice
    Sofia Moverare
    Department of Internal Medicine Division of Endocrinology, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    J Invest Dermatol 119:1053-8. 2002
    ..The aim of this study was to investigate the relative functional importance of estrogen receptor alpha and estrogen receptor beta in the regulation of the hair follicle cycling and epidermal thickness in ..
  21. pmc Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen
    Sanhita Ray
    Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Mol Endocrinol 22:1125-40. 2008
    Accumulating evidence indicates that estrogen regulates diverse but interdependent signaling pathways via estrogen receptor (ER)-dependent and -independent mechanisms...
  22. doi DNA binding by estrogen receptor-alpha is essential for the transcriptional response to estrogen in the liver and the uterus
    Dörthe L Ahlbory-Dieker
    Bayer Schering Pharma AG, Therapeutic Research Group Women s Healthcare, Mullerstrasse 178, 13353 Berlin, Germany
    Mol Endocrinol 23:1544-55. 2009
    The majority of the biological effects of estrogens in the reproductive tract are mediated by estrogen receptor (ER)alpha, which regulates transcription by several mechanisms...
  23. pmc Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and Central Arkansas Veterans Health Care System, Little Rock, AR, USA
    J Bone Miner Res 25:769-81. 2010
    ..We have searched for the molecular mechanism of these effects using as tools a mouse model bearing an estrogen receptor alpha (ERalpha) knock-in mutation that prevents binding to DNA (ERalpha(NERKI/-)) and several osteoblast ..
  24. pmc Testosterone and 17β-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice
    Sophie Doublier
    Study Group and Laboratory on Sex and Gender Differences in Health and Disease, Department of Surgery, University of Miami Leonard M Miller School of Medicine, Miami, Florida, USA
    Kidney Int 79:404-13. 2011
    ..Female estrogen receptor knockout mice develop glomerulosclerosis at 9 months of age due to excessive ovarian testosterone production ..
  25. ncbi Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling
    Ulrich Ohnemus
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Endocrinology 146:1214-25. 2005
    ..Between the two recognized estrogen receptors (ERs), ER alpha and ER beta, only ER alpha had been detected in murine skin...
  26. ncbi The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen
    Takeshi Kurita
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Differentiation 73:313-22. 2005
    The activation function-1 (AF-1) domain of the estrogen receptor alpha (ERalpha) in stromal cells has been shown to be required for epithelial responses to estrogen in the mouse uterus...
  27. doi Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytes
    Nina D Ullrich
    Imperial College London, Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Physiol Heart Circ Physiol 294:H2421-7. 2008
    ..measured the effect of estrogens on Ca2+ current (ICaL) in isolated ventricular cardiomyocytes of wild-type (WT), ERalpha knockout (ERalphaKO), and ERbetaKO mice using the whole cell patch-clamp technique at 37 degrees C...
  28. ncbi 17beta-estradiol alters the activity of conventional and IFN-producing killer dendritic cells
    Mark C Siracusa
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Immunol 180:1423-31. 2008
    ..These data illustrate that E2 has differential effects on the development and function of DCs and IKDCs and provide evidence that E2 may strengthen innate immunity by enhancing IFN-gamma production by CD11c(+) cells...
  29. pmc Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland
    Sonia Mallepell
    National Center of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, 155 Chemin des Boveresses, CH 1066 Epalinges s Lausanne, Switzerland
    Proc Natl Acad Sci U S A 103:2196-201. 2006
    ..Estradiol is a major regulator of postnatal mammary gland development and thought to exert its effects through estrogen receptor alpha (ERalpha) expressed in the mammary gland stroma and epithelium...
  30. doi Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network
    Céline E Toutain
    Institut National de la Sante et de la Recherche Medicale, U858, Toulouse, France
    Circ Res 104:245-54, 12p following 254. 2009
    ..Finally, this protective effect of E2 was abolished in estrogen receptor-deficient mice (ERalpha(-/-)) but maintained in chimeric mice reconstituted with ERalpha-deficient bone ..
  31. doi 17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1
    Marlene Vind Hofmeister
    Dept of Biomedicine, The Water and Salt Research Center, Aarhus Univ, Aarhus C, Denmark
    Am J Physiol Renal Physiol 302:F358-68. 2012
    ..G protein-coupled estrogen receptor 1 (GPER1 or GPR30) was detected in microdissected DCT2/CNT/iCCD by RT-PCR...
  32. pmc Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice
    Jie Tian
    Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas 78957, USA
    J Clin Invest 122:192-204. 2012
    ..As ERα levels are elevated during the prepubertal and postmenopausal stages, these may represent windows of susceptibility during which increased IGF-1 exposure maximally enhances breast cancer risk...
  33. doi Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERα cross talk
    Elaine Emmerson
    The Healing Foundation Centre, The University of Manchester, Manchester, UK
    J Invest Dermatol 132:2838-48. 2012
    ..The fact that IGF-1 may compensate for estrogen deficiency in wound repair, and potentially other contexts, is an important consideration for the treatment of postmenopausal pathology...
  34. pmc Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
    J Clin Invest 123:394-404. 2013
    The detection of estrogen receptor-α (ERα) in osteoblasts and osteoclasts over 20 years ago suggested that direct effects of estrogens on both of these cell types are responsible for their beneficial effects on the skeleton, but the ..
  35. pmc Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene
    Sylvia C Hewitt
    Laboratory of Reproductive and Developmental Toxicology, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 24:4660-7. 2010
    To address issues resulting from α estrogen receptor-knockout (αERKO) residual N-terminal truncated estrogen receptor α, and to allow tissue-selective deletion of ERα, we generated loxP-flanked exon 3 mice...
  36. ncbi Role of estrogen receptor-alpha in the anterior pituitary gland
    K M Scully
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093 0648, USA
    Mol Endocrinol 11:674-81. 1997
    Targeted insertional disruption of the mouse estrogen receptor-alpha (ER alpha) gene has provided a genetic model in which to test hypotheses that estrogens exert important effects in development and homeostatic functions of the anterior ..
  37. ncbi Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice
    Marie K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    Mol Endocrinol 17:203-8. 2003
    ..The aim of the present study was to determine the role of estrogen receptor-beta (ERbeta) in vivo on global estrogen-regulated transcriptional activity in bone...
  38. ncbi Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements
    Jeanne E O'Brien
    Division of Reproductive Endocrinology and Infertility, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:26683-92. 2006
    Acting via the estrogen receptor (ER), estradiol exerts pleomorphic effects on the uterus, producing cyclical waves of cellular proliferation and differentiation in preparation for embryo implantation...
  39. ncbi Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes
    T L Dellovade
    Department of Biomedical Sciences, The Eunice Kennedy Shriver Center, Program in Neuroscience, Harvard Medical School, Waltham, Massachusetts 02452, USA
    J Comp Neurol 423:579-89. 2000
    ..by E15, the developing VMH is demarcated further by cells that are immunoreactive for neuropeptide Y, estrogen receptor alpha (ERalpha), and galanin...
  40. pmc P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis
    Robin Fuchs-Young
    Department of Molecular Carcinogenesis, The Virginia Harris Cockrell Cancer Research Center at The University of Texas MD Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, Smithville, TX 78957, USA
    Breast Cancer Res Treat 130:399-408. 2011
    Clinical studies show that estrogen receptor-α (ER) expressing tumors tend to have better prognosis, respond to antiestrogen therapy and have wild-type p53...
  41. ncbi In vivo functional analysis of the mouse estrogen receptor gene promoter: a transgenic mouse model to study tissue-specific and developmental regulation of estrogen receptor gene transcription
    L Cicatiello
    Istituto di Patologia Generale e Oncologia, Facolta di Medicina e Chirurgia, Seconda Universita di Napoli, Italy
    Mol Endocrinol 9:1077-90. 1995
    ..during ontogenesis requires identification of the genetic controls that determine timed expression of the estrogen receptor (ER) gene in multiple cell types...
  42. ncbi Disproportional body growth in female estrogen receptor-alpha-inactivated mice
    O Vidal
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, Goteborg, S 41345, Sweden
    Biochem Biophys Res Commun 265:569-71. 1999
    ..Two estrogen receptors, ERalpha and ERbeta, have been cloned...
  43. ncbi Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus
    C S Rosenfeld
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Mol Reprod Dev 59:336-46. 2001
    b>Estrogen receptor (ER)- (alpha, beta, and both alpha and beta) and aromatase (Ar) knockout (KO) mice have been created to assess the biological effects of estrogens...
  44. ncbi Estrogen receptor specificity in the regulation of the skeleton in female mice
    M K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    J Endocrinol 171:229-36. 2001
    There are two known estrogen receptors, estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta), which may mediate the actions of estrogen...
  45. pmc Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function
    Q Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 98:14132-7. 2001
    b>Estrogen receptor alpha (ER alpha) is essential for male fertility...
  46. pmc Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes
    Borja Belandia
    Institute of Reproductive and Developmental Biology, Imperial College Faculty of Medicine, Du Cane Road, London W12 0NN, UK
    EMBO J 21:4094-103. 2002
    ..a catalytic subunit in the mammalian SWI/SNF complex, is required for transcriptional activation by the estrogen receptor, but the mechanisms by which the complex is recruited to estrogen target genes are unknown...
  47. ncbi Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse
    M Kos
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Mol Endocrinol 29:281-6. 2002
    The mouse knockout of the estrogen receptor alpha (ERalpha) gene, known as alphaERKO, has been extensively used for several years to study the role and function of ERalpha...
  48. ncbi Smad 3 regulates proliferation of the mouse ovarian surface epithelium
    Daniel Symonds
    Department of Epidemiology and Preventive Medicine, Program in Toxicology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Anat Rec A Discov Mol Cell Evol Biol 273:681-6. 2003
    ..WT OSE had less immunostaining for proliferating cell nuclear antigen (PCNA) and estrogen receptor alpha (ERalpha) than Smad 3 -/- OSE...
  49. pmc The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97201, USA
    Am J Pathol 163:1599-605. 2003
    ..role of intracytoplasmic estrogen receptors in mediating suppression of EAE, we studied mice with disrupted estrogen receptor-alpha (Esr1) and -beta (Esr2) genes. We demonstrate that the protective effect of E2 is abrogated in B6...
  50. ncbi Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice
    A S Chagin
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    J Bone Miner Res 19:72-7. 2004
    ..longitudinal bone growth, appendicular and axial skeletal growth was followed and compared in female ER beta-/-, ER alpha-/-, and ER alpha-/- beta-/- mice...
  51. ncbi Estrogen receptor beta-mediated inhibition of male germ cell line development in mice by endogenous estrogens during perinatal life
    Geraldine Delbes
    Unité de Gamétogenèse et Génotoxicité, Institut National de la Sante et de la Recherche Medicale Unite 566, Commissariat a l Energie Atomique, Universite Paris 7 Denis Diderot, 92265 Fontenay aux Roses, France
    Endocrinology 145:3395-403. 2004
    ..We addressed this question by studying the testicular development of mice in which the estrogen receptor (ER) beta or the ERalpha gene was inactivated...
  52. ncbi Susceptibility to early atherosclerosis in male mice is mediated by estrogen receptor alpha
    Amparo Villablanca
    Department of Internal Medicine, University of California, Davis, One Shields Ave, TB 172, Davis, CA 95616 8636, USA
    Arterioscler Thromb Vasc Biol 24:1055-61. 2004
    Vascular tissues express 2 types of estrogen receptors (ERs): ERalpha and ERbeta. Their role in early atherosclerosis remains poorly understood, particularly in males...
  53. ncbi Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment
    Magdalena J Polanczyk
    Department of Neurology, Oregon Health and Science University, and Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 173:2227-30. 2004
    ..autoimmune encephalomyelitis) correlated with its ability to up-regulate FoxP3, as both were reduced in estrogen receptor alpha-deficient animals...
  54. pmc Estren-mediated inhibition of T lymphopoiesis is estrogen receptor-independent whereas its suppression of T cell-mediated inflammation is estrogen receptor-dependent
    U Islander
    Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Goteborg, Sweden
    Clin Exp Immunol 139:210-5. 2005
    ..of estrogen receptors (ER) in the effects of E2 and estren on the immune system, ER knock-out mice lacking both ERalpha and ERbeta (DERKO) were used...
  55. ncbi Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ
    M Silvina Frech
    Lombardi Comprehensive Cancer Center, Departments of Oncology and Pathology, Georgetown University, 3970 Reservoir Road, Washington, DC 20057, USA
    Cancer Res 65:681-5. 2005
    A conditional tetracycline-responsive transgenic mouse model with deregulated estrogen receptor alpha expression in mammary epithelial cells developed ductal hyperplasia (DH), lobular hyperplasia, and ductal carcinoma in situ (DCIS) by 4 ..
  56. ncbi Estrogen receptor alpha (ERalpha) deficiency in macrophages results in increased stimulation of CD4+ T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4+ T cells independent of antigen presentation
    K Chad Lambert
    Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA
    J Immunol 175:5716-23. 2005
    ..and patterns of cytokine expression (increased proinflammatory cytokine expression) through amelioration of ERalpha signaling...
  57. pmc Functional estrogen receptors in the mitochondria of breast cancer cells
    Ali Pedram
    Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, Long Beach, CA 90822, USA
    Mol Biol Cell 17:2125-37. 2006
    ..the mitochondria of MCF-7 breast cancer cells and endothelial cells, compatible with classical estrogen receptors ERalpha and ERbeta...
  58. pmc Keratin 6 is not essential for mammary gland development
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 8:R29. 2006
    ....
  59. pmc Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland
    Katherine E Sleeman
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, England, UK
    J Cell Biol 176:19-26. 2007
    The role of estrogen in promoting mammary stem cell proliferation remains controversial. It is unclear if estrogen receptor (ER)-expressing cells have stem/progenitor activity themselves or if they act in a paracrine fashion to stimulate ..
  60. ncbi Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)
    Magdalena J Polanczyk
    Neuroimmunology Research, Veterans Affairs Medical Center, R and D 31, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Int Immunol 19:337-43. 2007
    ..FoxP3 in E2-enhanced Treg suppression, we evaluated both markers and functional suppression in wild-type, estrogen receptor knockout (ERKO) mice and PD-1 KO mice...
  61. ncbi Effects of estrogen receptor subtype-selective agonists on autoimmune disease in lupus-prone NZB/NZW F1 mouse model
    Jing Li
    Department of Endocrinology, The First Hospital Affiliated to China Medical University, Shenyang, 110001, P R China
    Clin Immunol 123:219-26. 2007
    The specific roles of estrogen receptor (ER) subtypes alpha and beta in mediating estrogen's influences on lupus autoimmunity are unknown...
  62. pmc Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment
    Seema Tiwari-Woodruff
    Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, University of California, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:14813-8. 2007
    Treatment with either estradiol or an estrogen receptor (ER)alpha ligand has been shown to be both antiinflammatory and neuroprotective in a variety of neurological disease models, but whether neuroprotective effects could be observed in ..
  63. pmc GPR30 contributes to estrogen-induced thymic atrophy
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Mol Endocrinol 22:636-48. 2008
    ..In this study, the roles played by the membrane estrogen receptor, G protein-coupled receptor 30 (GPR30), and the intracellular estrogen receptors, estrogen receptor alpha (..
  64. pmc An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo
    Kerstin W Sinkevicius
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Endocrinology 149:2970-9. 2008
    Estrogen-nonresponsive estrogen receptor-alpha (ERalpha) knock-in (ENERKI) mice were generated to distinguish between ligand-induced and ligand-independent ER-alpha actions in vivo...
  65. doi Expression and localization of estrogen receptor alpha in the C2C12 murine skeletal muscle cell line
    Lorena Milanesi
    Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, 8000 Bahia Blanca, Argentina
    J Cell Biochem 104:1254-73. 2008
    The classical model of 17beta-estradiol action has been traditionally described to be mediated by the estrogen receptor (ER) localized exclusively in the nucleus...
  66. ncbi Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway
    Bertrand Calippe
    Institut National de la Santé et de la Recherche Médicale U858, Institut de Medecine Moleculaire de Rangueil, IFR31, Toulouse, France
    J Immunol 180:7980-8. 2008
    ..been reported to decrease the production of proinflammatory cytokines by LPS-activated macrophages through estrogen receptor alpha (ERalpha)-dependent activation of the PI3K pathway...
  67. doi Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice
    Elodie Riant
    Institut National de la Santé et de la Recherche Médicale Unité 858, Institut de Medecine Moleculaire de Rangueil, Boite Postale 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 150:2109-17. 2009
    ..Although corroborating data indicate that estrogens influence glucose metabolism through the activation of the estrogen receptor alpha (ERalpha), it has not been established whether this pathway could represent an effective therapeutic ..
  68. doi Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30
    Cecilia Engdahl
    Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    Arthritis Rheum 62:524-33. 2010
    ..via the nuclear estrogen receptors (ERs) ERalpha or ERbeta or via the recently proposed transmembrane estrogen receptor G protein-coupled receptor 30 (GPR-30)...
  69. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
    ..Prenatal male and female reproductive tract development can therefore occur in the absence of estradiol receptor-mediated responsiveness.
  70. ncbi Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene
    J F Couse
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 9:1441-54. 1995
    We employed homologous recombination in mouse embryonic stem cells to disrupt the estrogen receptor (ER) gene...
  71. ncbi Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice
    M D Iafrati
    Molecular Cardiology Research Center, New England Medical Center, Tupper Research Institute, Boston, Massachusetts 02111, USA
    Nat Med 3:545-8. 1997
    ..Blood vessel cells express the classic estrogen receptor, ER alpha (ref...
  72. ncbi Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
    K Paech
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
    Science 277:1508-10. 1997
    The transactivation properties of the two estrogen receptors, ERalpha and ERbeta, were examined with different ligands in the context of an estrogen response element and an AP1 element...
  73. ncbi Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations
    J E Staples
    Department of Microbiology, State University of New York Health Science Center, Syracuse 13210, USA
    J Immunol 163:4168-74. 1999
    ..To determine how estrogens influence the thymus and affect T cell development, estrogen receptor alpha (ERalpha) knockout (ERKO) mice were examined...
  74. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    ..of estrogen receptors (ERs) in mouse ovary and genital tracts were investigated by generating null mutants for ERalpha (ERalphaKO), ERbeta (ERbetaKO) and both ERs (ERalphabetaKO)...
  75. pmc Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice
    J B Hodgin
    Department of Pathology and Laboratory Medicine, University of North Carolina, 703 Brinkhous Bullitt Building, Chapel Hill, North Carolina 27599 7525, USA
    J Clin Invest 107:333-40. 2001
    ..are not understood, but most are thought to be mediated through estrogen receptors (ERs), of which two are known (ERalpha and ERbeta)...
  76. pmc Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on thymus
    M C Erlandsson
    Department of Rheumatology, University of Goteborg, Sweden
    Immunology 103:17-25. 2001
    ....
  77. ncbi Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk
    Diane M Klotz
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 277:8531-7. 2002
    ..growth factor-1 (IGF-1) signaling can be initiated by estradiol acting through its nuclear receptor (estrogen receptor (ER)) to stimulate the local synthesis of IGF-1...
  78. pmc The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice
    C Pendaries
    Institut National de la Santé et de la Recherche Médicale U397 et Laboratoire de Physiologie, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, 31054 Toulouse, France
    Proc Natl Acad Sci U S A 99:2205-10. 2002
    Two isoforms of estrogen receptor (ER) have been described: ERalpha and ERbeta...
  79. ncbi Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury
    Gary Pare
    Molecular Cardiology Research Institute, New England Medical Center, Boston, Massachusetts, USA
    Circ Res 90:1087-92. 2002
    ..responsiveness in ERalpha,betaKO(CH) mice could be due either to the presence of a novel, unidentified estrogen receptor or to functional expression of an estrogen receptor-alpha splice variant in the parental ERalphaKO(CH) mice...
  80. ncbi Localization of androgen and estrogen receptors in adult male mouse reproductive tract
    Qing Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    J Androl 23:870-81. 2002
    ..In this study, androgen receptor (AR) and estrogen receptors ERalpha and ERbeta were visualized by immunohistochemistry in adult male mice reproductive tracts, including testes, ..
  81. ncbi Minireview: estrogen and mouse models of atherosclerosis
    Jeffrey B Hodgin
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    Endocrinology 143:4495-501. 2002
    ....
  82. ncbi Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity
    Sonoko Ogawa
    Laboratory of Neurobiology and Behavior, Rockefeller University, New York, New York 10021, USA
    Endocrinology 144:230-9. 2003
    ..In particular, little is known about the separate roles of two types of estrogen receptors, ERalpha and ERbeta, both of which are expressed in mPOA neurons...
  83. ncbi Global transcription profiling of estrogen activity: estrogen receptor alpha regulates gene expression in the kidney
    Scott A Jelinsky
    Genomics Department, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Endocrinology 144:701-10. 2003
    ..d ED(50) for c-fos induction in the uterus. E2 regulations in the kidney were intact in ERbetaKO mice, and the ERalpha-selective agonist propylpyrazole triol acted similarly to E2, together suggesting an ERalpha-mediated mechanism...
  84. ncbi Estrogen receptor-alpha dependency of estrogen's stimulatory action on cancellous bone formation in male mice
    Kathleen E McDougall
    Academic Rheumatology, University of Bristol, Bristol BS2 8HW, United Kingdom
    Endocrinology 144:1994-9. 2003
    We examined whether estrogen receptor (ER)alpha is required for estrogen to stimulate cancellous bone formation in long bones of male mice...
  85. ncbi Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha
    Sudha Warrier Mitra
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Endocrinology 144:2055-67. 2003
    b>Estrogen receptor alpha (ER alpha) and ER beta are members of the steroid nuclear receptor family that modulate gene transcription in an estrogen-dependent manner...
  86. ncbi Endocrinology: bone adaptation requires oestrogen receptor-alpha
    Karla Lee
    Department of Veterinary Basic Sciences, The Royal Veterinary College, London NW1 0TU, UK
    Nature 424:389. 2003
  87. ncbi Transgenic models of metabolic bone disease: impact of estrogen receptor deficiency on skeletal metabolism
    L K McCauley
    Department of Periodontics, University of Michigan, Ann Arbor, Michigan, USA
    Connect Tissue Res 44:250-63. 2003
    ..Mechanisms for these effects and the selectivity to the estrogen receptor alpha (ER alpha) or ER beta are unclear...
  88. ncbi Double oestrogen receptor alpha and beta knockout mice reveal differences in neural oestrogen-mediated progestin receptor induction and female sexual behaviour
    A E Kudwa
    Neuroscience Graduate Program, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Neuroendocrinol 15:978-83. 2003
    To test the hypothesis that oestrogen receptor alpha (ERalpha) and ERbeta act together to mediate the actions of oestrogen in the ventromedial hypothalamus (VMH), we used mice with single or double knockout mutations of the ERalpha and ..
  89. pmc Brain masculinization requires androgen receptor function
    Takashi Sato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 101:1673-8. 2004
    ..but rather through its conversion by brain aromatase into estrogen, with the consequent activation of estrogen receptor (ER)-mediated signaling...
  90. ncbi The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta
    K C L Lee
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    J Endocrinol 182:193-201. 2004
    ..the ulna's adaptive response to mechanical loading in adult female mice lacking oestrogen receptor-alpha (ERalpha(-/-)), those lacking oestrogen receptor-beta (ERbeta(-/-)) and their wild-type littermates...
  91. ncbi Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism
    Sylvia Curtis Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 19:657-68. 2005
    Cross-talk between growth factor receptors and the estrogen receptor (ER) has been proposed as a signaling mechanism in estrogen target tissues, with ER(alpha) as a direct target of growth factor receptor-activated signals, leading to ..
  92. ncbi Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha
    Geraldine Delbes
    Unité de Gamétogenèse et Génotoxicité, Institut National de la Sante et de la Recherche Medicale Unite 566, Commissariat a l Energie Atomique, Universite Paris 7, Denis Diderot, Fontenay aux Roses, France
    Endocrinology 146:2454-61. 2005
    ..However, the estrogen receptor (ER)-mediated processes involved in the regulation of male reproduction during fetal and neonatal ..
  93. ncbi Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-alpha-deficient male and female mice
    Vilhelmiina Parikka
    Department of Anatomy and Medicity Research Laboratory, University of Turku, FIN 20700 Turku, Finland
    Eur J Endocrinol 152:301-14. 2005
    ..Although the beneficial effects of estrogen on bone are well known, the roles of estrogen receptors (ERs) in mediating these effects are not fully understood...
  94. ncbi Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11
    Luisa A Helguero
    Department of Medical Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    Oncogene 24:6605-16. 2005
    The mitogenic effect of 17beta-estradiol (E2) on the breast is mediated by estrogen receptor alfa (ERalpha), hence ERalpha antagonists are effective in the treatment of breast cancer...
  95. ncbi Compensatory kidney growth in estrogen receptor-alpha null mice
    Jianhong Sun
    982169 Nebraska Medical Center, Omaha, NE 68198 2169, USA
    Am J Physiol Renal Physiol 290:F319-23. 2006
    ..and the kidney, we examined compensatory kidney growth (CKG) after uninephrectomy (Unx) in wild-type and estrogen receptor-alpha null mice (ERKO)...
  96. pmc Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha
    Rodrigo P A Barros
    Department of Biosciences and Nutrition, Karolinska Institute, S 141 86 Novum, Sweden
    Proc Natl Acad Sci U S A 103:1605-8. 2006
    ..In the present study, we investigated the expression of the two estrogen receptors, ERalpha and ERbeta, and their influence on regulation of the glucose transporter, GLUT4, and its associated structural ..
  97. ncbi Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver
    G Bryzgalova
    Department of Molecular Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Diabetologia 49:588-97. 2006
    We used oestrogen receptor-alpha (ERalpha) knockout (ERKO) and receptor-beta (ERbeta) knockout (BERKO) mice to investigate the mechanism(s) behind the effects of oestrogens on glucose homeostasis.
  98. pmc Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice
    Cedric Le May
    Division of Diabetes, Endocrinology and Metabolism, Department of, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:9232-7. 2006
    ..In addition, estradiol has antiapoptotic actions in cells that are mediated by the estrogen receptor-a (ERalpha), raising the prospect that estradiol antidiabetic function may be due, in part, to a protection ..
  99. ncbi Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility
    Tim M Wintermantel
    Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Neuron 52:271-80. 2006
    ..We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mutant mice...
  100. pmc Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor
    Stavroula Kousteni
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Mol Cell Biol 27:1516-30. 2007
    Estrogens control gene transcription by cis or trans interactions of the estrogen receptor (ER) with target DNA or via the activation of cytoplasmic kinases...
  101. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...

Research Grants35

  1. REMEDIATION OF EMPHYSEMA--MECHANISMS, CHARACTERISTICS
    Donald Massaro; Fiscal Year: 2001
    ....
  2. EXPERIMENTAL EMPHYSEMA--STUDIES ON REMEDIATION
    Donald Massaro; Fiscal Year: 2001
    ....
  3. Alveolar Biology: Sex, Age, and Alveolar Turnover
    Donald Massaro; Fiscal Year: 2007
    ..Key new findings since the last submission are: 1. Adult female estrogen receptor (ER)alpha and ERbeta k.o...
  4. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..There is not treatment that slows the relentless progression of the disease or that reverses it. In this application, we use an animal model to investigate methods to slow progression and reverse the disease. ..
  5. TISSUE INTERACTIONS AND HORMONAL RESPONSES IN THE UTERUS
    Robert Bigsby; Fiscal Year: 2004
    ..proliferation in the uterine stroma occurs indirectly through activation of progesterone receptor (PR) and estrogen receptor-alpha (ER alpha) in the overlying epithelium...
  6. BEHAVIORAL REGULATION OF NEUROENDOCRINE CELLS
    EMILIE RISSMAN; Fiscal Year: 2005
    ..of androgen to estrogen in the activation of these behaviors lead her to begin working with the estrogen receptor alpha knockout mouse (ERaKOs)...
  7. Endocrine Regulation of Hepatocellular Carcinogenesis
    Robert Bigsby; Fiscal Year: 2007
    ..Although the liver expresses estrogen receptor (ERa), the protective effects of estrogen may be mediated through prolactin (PRL); whether liver ERa or PRL ..
  8. Reproduction, Nutrition and Behavior
    EMILIE RISSMAN; Fiscal Year: 2008
    ..It is likely that this information will provide new approaches for the study of GnRH-II peptide in humans. Moreover, this work may provide insights into physiological bases of eating disorders. [unreadable] [unreadable]..
  9. Sex chromosome effects on neural and behavioral differentiation
    Emilie F Rissman; Fiscal Year: 2011
    ..The work will also enrich and inform our knowledge of sex differences in both normal and clinical populations. ..
  10. GENETIC MECHANISMS OF ESTROGEN ATHEROPROTECTION
    Amparo Villablanca; Fiscal Year: 2003
    ..The overall goal of the research proposal is to understand the action of estradiol, the estrogen receptor, and estrogen/receptor interactions on atheroprotection, vascular function and gene expression in mice...
  11. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    ....
  12. Nongenomic Signaling Mechanisms of Environmental Estrogens
    Cheryl S Watson; Fiscal Year: 2011
    ..In cells that express a membraneform of the estrogen receptor-a (mERa), each xenoestrogen elicited unique signaling patterns (temporal, dose-response) via activation of ..
  13. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2009
    ..However, E2 responsiveness decreases with advanced age possibly due to a loss of ERalpha associated transcription. The current study will determine which hippocampal genes are linked to ERalpha activity...
  14. Development Estrogenization of the Rat Prostate Gland
    Gail S Prins; Fiscal Year: 2010
    ..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...
  15. Signaling cascades and memory deficits during aging
    Thomas C Foster; Fiscal Year: 2010
    ..The long range goal is to provide interventions to delay, prevent, or treat cognitive decline associated with unsuccessful aging in order to improve the health and well- being of older Americans ..
  16. Hypoxia-Induced Mitogenic Factor in Perinatal Lung
    Dechun Li; Fiscal Year: 2006
    ..It will utilize comprehensive promoter-reporter transfection studies, EMSA, footprinting, and overexpression studies to define the protein-DNA interactions critical to HIMF gene expression during the perinatal period. ..
  17. N-3 fatty acid & binding protein MRG on mammary tumor
    YUENIAN SHI; Fiscal Year: 2006
    ..These studies will help to identify MRG as mediator for differentiation for mammary gland and for interaction with n-3 PUPA on inhibition of mammary tumorigenesis. ..
  18. Endocytosis and trafficking of PRL receptor isoforms
    Linda Schuler; Fiscal Year: 2006
    ..4. Determine the role of dimerization in this process, and the effect of homo- vs. hetero-dimerization using chimeric receptors and PRL antagonists. ..
  19. PROGESTERONE RECEPTOR IN MYOMETRIUM AND LEIOMYOMA
    Robin Fuchs Young; Fiscal Year: 2002
    ....
  20. MAMMARY PROLACTIN PRODUCTION AND BREAST CANCER
    Linda Schuler; Fiscal Year: 2005
    ..during tumorigenesis, using our transgenic mice overexpressing PRL and/or TGFa, to examine the effect of E2 and ERa on tumor development and progression, and identify target genes and signaling pathways that are active in the ..
  21. PREHAB VS REHAB FOR REDUCING BEDREST EFFECTS WITH AGING
    Marybeth Brown; Fiscal Year: 2002
    ..If preliminary findings are confirmed, it would provide support for appropriate human studies, and for expansion of habilitation services to older adults to include both pre-habilitation and rehabilitation. ..
  22. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
    ....
  23. EXERCISE SPECIFICITY FOR PHYSICAL FRAILTY
    Marybeth Brown; Fiscal Year: 2004
    ..3. Determine if the gains from each exercise program can be sustained for 3 months. ..
  24. Estrogen Receptor Gene Transfer in Mouse Brains
    Sonoko Ogawa; Fiscal Year: 2004
    ..The outcome of the proposed studies will provide valuable information about mechanisms of action of two types of ERs in the brain. ..
  25. CONTROL OF ALCOHOL INTAKE BY BRAIN-GUT PEPTIDES
    NORCROSS GEARY; Fiscal Year: 2003
    ..The work will be closely coordinated, and we expect this cooperative effort to be very productive. ..
  26. Environmental Estrogens Acting via a Membrane Receptor
    CHERYL WATSON; Fiscal Year: 2004
    ..We have characterized the alpha form of the estrogen receptor (ERalpha) in the plasma membrane of GH3/B6 pituitary tumor cells, which serve as a model for membrane-..
  27. IGF-1 Signaling & ER crosstalk in mammary cancer in vivo
    Robin Fuchs Young; Fiscal Year: 2008
    ..Studies show that both pathways are involved in crosstalk with the estrogen receptor (ER) and enhance receptor activity through phosphorylation of specific serine residues...
  28. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2008
    ..controls of meal size by identifying cellular co-localization of feeding-elicited c-Fos expression and estradiol receptor-alpha expression...
  29. MIDAS PROJECT/MODEL/IMPLEMENTATION/DISSEMINATION/EHS
    Robin Fuchs Young; Fiscal Year: 2007
    ..This project seeks to improve the understanding of environmental health and science by teachers and their students and enable both to make informed decisions about the environment and their health. ..
  30. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..Health implications: New treatments to prevent diabetic kidney disease, the most important cause of kidney failure in the US, may emerge from a better understanding of a naturally protected state such as the prepubertal animal. ..
  31. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
    ..Finally, knowledge of estrogen responsive sensory neurons has important implications for understanding neuropathic pain syndromes influenced by estrogen levels. ..
  32. Tooth Eruption: Role of Dental Follicle & PTH Receptor
    Laurie McCauley; Fiscal Year: 2006
    ..Furthermore, these studies will enhance our basic knowledge as to the role of PTHrP and PTH-1R interactions in controlling mineralized tissue homeostasis. ..
  33. ROLE OF ALPHA & BETA ESTROGEN RECEPTORS IN AGGRESSION
    Sonoko Ogawa; Fiscal Year: 2003
    ..The findings of the proposed studies will provide new insights concerning the specific roles and mechanisms played by the two types of ERs in the sex-specific regulation of aggressive behavior by gonadal steroids. ..
  34. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
    ..We have also shown that: aromatase overexpression affects the expression of estrogen receptor (ER) and progesterone receptor (PR), and the expression of various growth factors, oncogenes, tumor ..