Genomes and Genes
Gene Symbol: Erbb3
Description: erb-b2 receptor tyrosine kinase 3
Alias: C76256, Erbb-3, Erbb3r, Her3, receptor tyrosine-protein kinase erbB-3, avian erythroblastosis oncogene B 3 receptor, c-erbB-3, glial growth factor receptor, proto-oncogene-like protein c-ErbB-3, receptor tyrosine kinase, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
Publications115 found, 100 shown here
- The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactionsI Alroy
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
FEBS Lett 410:83-6. 1997..The resulting signaling network has important implications for embryonic development and malignant transformation...
- Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactionsIrina J Fox
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
J Neurosci Res 79:584-97. 2005The ErbB family, ErbB1 (also known as the epidermal growth factor receptor EGFR), ErbB2, ErbB3, and ErbB4 comprise a group of receptor tyrosine kinases that interact with ligands from the epidermal growth factor (EGF) superfamily, ..
- Role for HER2/neu and HER3 in fulvestrant-resistant breast cancerClodia Osipo
Department of Pathology, Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Medical Center, Maywood, IL, USA
Int J Oncol 30:509-20. 2007..However, tyrosine-phosphorylated HER2/ neu, HER3, phospho-extracellular-regulated kinase-1/2 (ERK-1/2), and phospho-glycogen synthetase kinase 3alpha (GSK3alpha) ..
- Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous systemBastian G Brinkmann
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
Neuron 59:581-95. 2008..Unexpectedly, these mice assemble normal amounts of myelin. In addition, double mutants lacking oligodendroglial ErbB3 and ErbB4 become myelinated in the absence of any stimulation by neuregulins...
- A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signalJanna Merte
The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neurosci 30:5767-75. 2010..Therefore, through the use of a forward-genetic screen we have identified a novel allele of Sema3A that provides structural insight into the mechanism of Sema3A/Npn-1/PlexinA signaling...
- Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferationMarion A Cooley
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
Dev Dyn 241:303-14. 2012..Here we investigated the involvement of fibulin-1 in ADAMTS1-mediated cleavage of versican in vitro, and the involvement of fibulin-1 in versican cleavage in ventricular morphogenesis...
- Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during developmentM Cristina Ortega
Grupo de Neurobiología del Desarrollo GNDe, Hospital Nacional de Paraplejicos, Toledo, Spain
Exp Neurol 235:610-20. 2012..The present findings reveal a new role for Nrg1/ErbB4 signaling in regulating OPC migration selectively during early stages of CNS development...
- Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapsesD Wolpowitz
Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
Neuron 25:79-91. 2000....
- Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumorsM H Kraus
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
Proc Natl Acad Sci U S A 86:9193-7. 1989..with structural features identifying it as a member of the ERBB gene family, prompting us to designate the gene as ERBB3. It was mapped to human chromosome 12q13 and was shown to be expressed as a 6...
- Multiple essential functions of neuregulin in developmentD Meyer
Nature 378:386-90. 1995..The biological effects of the factor are mediated by tyrosine kinase receptors. Neuregulin can bind directly to erbB3 and erbB4 and receptor heterodimerization allows neuregulin-dependent activation of erbB2 (refs 1, 2, 5)...
- Altered neural cell fates and medulloblastoma in mouse patched mutantsL V Goodrich
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
Science 277:1109-13. 1997..Mice heterozygous for the ptc mutation were larger than normal, and a subset of them developed hindlimb defects or cerebellar medulloblastomas, abnormalities also seen in BCNS patients...
- Severe neuropathies in mice with targeted mutations in the ErbB3 receptorD Riethmacher
Department of Medical Genetics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Nature 389:725-30. 1997..Here we use gene targeting to generate mice that lack ErbB3, a high-affinity neuregulin receptor...
- Isoform-specific expression and function of neuregulinD Meyer
Max Delbruck Center for Molecular Medicine, Department of Medical Genetics, Berlin, Germany
Development 124:3575-86. 1997..The complexity of neuregulin functions in development is therefore due to independent roles played by distinct isoforms...
- ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient miceS L Erickson
Department of Molecular Biology, Genetech Inc, South San Francisco, California 94080, USA
Development 124:4999-5011. 1997Heregulins bind directly to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor...
- Specificity within the EGF family/ErbB receptor family signaling networkD J Riese
Department of Pathology, Yale University, New Haven, CT, USA
Bioessays 20:41-8. 1998..family hormones can activate receptors in trans, and this heterodimerization diversifies biological responses; 5) ErbB3 requires a receptor partner for signaling; and 6) ErbB family receptors differentially couple to signaling ..
- erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantationH Lim
Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas, 66160 7338, USA
Dev Biol 204:97-110. 1998..No information is available about uterine and embryonic status of ErbB3 or ErbB4 during implantation...
- Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancerP M Siegel
Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
EMBO J 18:2149-64. 1999....
- Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptorsP J Miettinen
Department of Pathology and Transplantation Laboratory, The Haartman Institute, and Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
Development 127:2617-27. 2000..Upregulated PAI-1 production and decreased gelatinolytic activity correlated to this migration defect. An intact EGF-R pathway appears to be a prerequisite for normal pancreatic development...
- The transcription factor Sox10 is a key regulator of peripheral glial developmentS Britsch
Max Delbruck Center for Molecular Medicine, D 13122 Berlin, Germany
Genes Dev 15:66-78. 2001..Moreover, we show that Sox10 controls expression of ErbB3 in neural crest cells...
- Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutantD J Henderson
Neural Development Unit, Institute of Child Health, University College London, London UK
Circ Res 89:6-12. 2001..We suggest that the double-sided arch arises as a primary defect in the Lp mutant, unrelated to the alignment defects, perhaps reflecting a role for the (as-yet-unknown) Lp gene in maintenance/regression of the aortic arch system...
- Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signalingC Paratore
Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
Development 128:3949-61. 2001..Failures in fate decision processes might thus contribute to the etiology of Waardenburg/Hirschsprung disease...
- Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptorsTodd D Camenisch
College of Pharmacy and Steele Memorial Children s Research Center, University of Arizona, Tucson, Arizona, USA
Nat Med 8:850-5. 2002..lack mesenchyme formation, are rescued by heregulin treatment, which restores phosphorylation of ErbB2 and ErbB3. These events were blocked using a soluble ErbB3 molecule, as well as with an inhibitor of ErbB2, herstatin...
- Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular glandYuji Miyazaki
Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
Dev Dyn 230:591-6. 2004..Here, we report on the neuregulin (NRG) -1 protein and its receptors ErbB2 and ErbB3 in the developing SMG...
- Gene targeting of ErbB3 using a Cre-mediated unidirectional DNA inversion strategyShimian Qu
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6838, USA
Genesis 44:477-86. 2006..To test the feasibility of this strategy we targeted ErbB3, a member of the ErbB family of tyrosine kinase receptors, using this strategy...
- Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiationShih Chu Kao
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Science 323:651-4. 2009..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells...
- Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epitheliumDaekee Lee
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
J Clin Invest 119:2702-13. 2009..Although the upregulation of ERBB3, a pseudo-kinase member of the EGFR/ERBB family, is known to contribute to EGFR inhibitor resistance in other ..
- Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cellsAeree Kim
Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK, USA
Breast Cancer Res 7:R708-18. 2005Co-expression of several receptor tyrosine kinases (RTKs), including erbB2 and erbB3, is frequently identified in breast cancers...
- Identification of ErbB3-stimulated genes using modified representational difference analysisC F Edman
Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA 92093 0684, U S A
Biochem J 323:113-8. 1997..used a PCR-based subtractive approach to identify differences in messages induced in response to activation of ErbB3 and EGFR...
- The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous systemS Britsch
Department of Medical Genetics, Max Delbruck Center MDC for Molecular Medicine, 13122 Berlin, Germany
Genes Dev 12:1825-36. 1998..Here, we report a novel phenotype in mice with targeted mutations in the erbB2, erbB3, or neuregulin-1 genes. These three mutations cause a severe hypoplasia of the primary sympathetic ganglion chain...
- The homeobox gene Phox2b is essential for the development of autonomic neural crest derivativesA Pattyn
Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
Nature 399:366-70. 1999....
- Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosoureaHang Zhou
Division of Hematology Oncology and Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, OH 44106 4937, USA
Oncogene 21:8732-40. 2002..This erb-B-3 mouse lung cancer model will help dissect genetic changes in lung tumorigenesis and may be useful for chemoprevention studies...
- Molecular markers of cardiac endocardial cushion developmentAaron D Gitler
Department of Medicine, Cardiology Division, University of Pennsylvania Health System, 954 BRB II III, Philadelphia, Pennsylvania 19104, USA
Dev Dyn 228:643-50. 2003....
- Axonal neuregulin-1 regulates myelin sheath thicknessGalin V Michailov
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
Science 304:700-3. 2004..We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size...
- Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivoSandra Niendorf
Leibniz Institut fur Molekulare Pharmakologie, Krahmerstr 6, D 12207 Berlin, Germany
Mol Cell Biol 27:5029-39. 2007..tyrosine kinases (RTKs), like epidermal growth factor receptor, hepatocyte growth factor receptor (c-met), and ERBB3. UBPy-deficient cells exhibit aberrantly enlarged early endosomes colocalizing with enhanced ubiquitination and ..
- In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neuronsY Abe
Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Chuo Ku, Niigata 951 8585, Japan
Neuroscience 161:95-110. 2009..Modest signal for ErbB1 mRNA was also detected in a subset of dopaminergic neurons. ErbB3 mRNA was detectable at postnatal day 10, peaked at postnatal day 18, and colocalized with 2',3'-cyclic nucleotide ..
- Jun and JunD-dependent functions in cell proliferation and stress responseA Meixner
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
Cell Death Differ 17:1409-19. 2010....
- ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesisRebecca S Cook
Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Cancer Res 71:3941-51. 2011The ErbB receptor family member ErbB3 has been implicated in breast cancer growth, but it has yet to be determined whether its disruption is therapeutically valuable...
- Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylationShyuan T Ngo
School of Biomedical Sciences, University of Queensland, St Lucia, 4072, Queensland, Australia
J Cell Sci 125:1531-43. 2012..Thus two classic synaptic signalling systems (neuregulin-1 and n-agrin) converge upon MuSK to regulate postsynaptic differentiation...
- Uncoupling of PI3K from ErbB3 impairs mammary gland development but does not impact on ErbB2-induced mammary tumorigenesisHicham Lahlou
Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Cancer Res 72:3080-90. 2012The formation of ErbB2/ErbB3 heterodimers plays a critical role in ErbB2-mediated signaling in both normal mammary development and mammary tumor progression...
- Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3Erez Nitzan
Department of Medical Neurobiology, IMRIC and ELSC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 110:12709-14. 2013..Together, we propose that differential fate acquisition of neural crest-derived cells depends on their progressive segregation from the Foxd3-positive lineage. ..
- Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelinationMaria E Sheean
Developmental Biology Signal Transduction
Genes Dev 28:290-303. 2014..Previous work demonstrated that loss of ErbB3/Shp2 signaling impairs Schwann cell development and disrupts the myelination program...
- Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitorsVyacheslav Dyachuk
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden A V Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
Science 345:82-7. 2014..This nerve origin places cellular elements for generating parasympathetic neurons in diverse tissues and organs, which may enable wiring of the developing parasympathetic nervous system...
- The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart developmentMohamed Mlih
From the CNRS, UMR 7213, University of Strasbourg, 67401 Illkirch, France
J Biol Chem 290:2419-30. 2015..We find that not only the ErbB3/Neuregulin signaling pathway but also the baroreceptor reflex response, which have been functionally associated, ..
- ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomasXiaoling Song
Department of Pathology and Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut
Cancer Res 75:1035-45. 2015b>ERBB3, a member of the EGFR family of receptor tyrosine kinases, has been implicated in activation of the PI3K pathway in human lung adenocarcinomas driven by EGFR mutations...
- Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasksR Gerlai
Department of Neuroscience, Genentech Incorporated, Mail Stop 72, 1 DNA Way, South, San Francisco, CA 94080 4990, USA
Behav Brain Res 109:219-27. 2000..To investigate this the heregulin-1, ErbB2, or ErbB3 locus was disrupted in a targeted manner and mice heterozygous for the mutation were analyzed...
- erbB3 is dispensable for oligodendrocyte development in vitro and in vivoJohannes Schmucker
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Hamburg, Germany
Glia 44:67-75. 2003During development and in the adult, erbB2, erbB3, and erbB4 are expressed in many tissues and as heterodimers (B2/B3, B2/B4) serve as receptors for neuregulins...
- Essential role of Sox9 in the pathway that controls formation of cardiac valves and septaHaruhiko Akiyama
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 101:6502-7. 2004..Further, Sox9-deficient endocardial mesenchymal cells fail to express ErbB3, which is required for endocardial cushion cell differentiation and proliferation...
- Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formationFang Xu Jiang
Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
Differentiation 73:45-9. 2005..5 pancreatic cells to proliferate and form cystoid and solid colonies. These results demonstrate that laminin-1 and EGF signaling pathways interact to promote pancreas development...
- Comparison of melanoblast expression patterns identifies distinct classes of genesStacie K Loftus
National Institutes of Health, National Human Genome Research Institute, Genetic Disease Research Branch, Bethesda, MD, USA
Pigment Cell Melanoma Res 22:611-22. 2009....
- Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesisVictoria E Abraira
Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:e8981. 2010..In addition, other receptor tyrosine kinase binding partners have been identified for both Lrig1 and Lrig3, leaving open the question of whether ..
- Expression, localization, and regulation of the neuregulin receptor ErbB3 in mouse heartGenis Camprecios
Faculty of Biology, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Catalonia, Spain
J Cell Physiol 226:450-5. 2011..However, here we show the presence of ErbB3 in the mouse heart from birth to adulthood by Western blotting and real-time RT-PCR...
- Downregulation of ErbB3 by Wnt3a contributes to wnt-induced osteoblast differentiation in mesenchymal cellsNicolas Jullien
INSERM U606, University Paris Diderot, and Hospital Lariboisière, Paris, France
J Cell Biochem 113:2047-56. 2012..is upregulated by Wnt3a, and that this effect was counterbalanced by decreased expression of the NRG-1 receptor ErbB3. Consistently, exogenous NRG-1 had no effect on alkaline phosphatase (ALP) activity, an early marker of osteoblast ..
- Bone marrow-derived mesenchymal stem cells up-regulate acetylcholine receptor delta subunit through NRG/ErbB3-mediated mitogen-activated protein kinase pathwayLi Chen
Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
Clin Transl Sci 5:27-31. 2012..NRG-1 antibody added in conditional medium of BMSCs, si-ErbB3, and four Ras/Raf/MEK/ERK pathway inhibitors (FTS, Sulindac, U0126, and PD98059) were using to investigate the ..
- HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formationDavid B Vaught
Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
Cancer Res 72:2672-82. 2012Increasing evidence suggests that HER2-amplified breast cancer cells use HER3/ErbB3 to drive therapeutic resistance to HER2 inhibitors. However, the role of ErbB3 in the earliest events of breast epithelial transformation remains unknown...
- Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactionsZheping Huang
Department of Pediatrics, Women and Infants Hospital of Rhode Island and the Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
J Biol Chem 287:18091-102. 2012..These studies provide novel insights into the cell signaling mechanisms regulating ErbB family receptors in lung cell differentiation...
- Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expressionMayumi Nagashimada
Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan
J Clin Invest 122:3145-58. 2012..Our results also demonstrate that Sox10 regulation by PHOX2B is pivotal for the development and pathogenesis of the autonomic ganglia...
- A critical period for social experience-dependent oligodendrocyte maturation and myelinationManabu Makinodan
F M Kirby Neurobiology Center, Children s Hospital, Boston, MA 02115, USA
Science 337:1357-60. 2012..These alterations, which occur only during this critical period, are phenocopied by loss of oligodendrocyte ErbB3 receptors, and social isolation leads to reduced expression of the ErbB3 ligand neuregulin-1...
- The ciliary protein Ftm is required for ventricular wall and septal developmentChristoph Gerhardt
Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Dusseldorf, Germany
PLoS ONE 8:e57545. 2013..Thus, our study suggests ciliopathy as a cause of VSDs...
- Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscleL M Moscoso
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Dev Biol 172:158-69. 1995..ARIA-responsive myotubes expressed both erbB2 and erbB3, but little EGFR/erbB1 or erbB4. In adults, erbB2 and erbB3 were localized to the postsynaptic membrane...
- ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytesM Marikovsky
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Oncogene 10:1403-11. 1995..We conclude that different isoforms of NDF induce distinct growth regulatory effects on cultured keratinocytes, through direct interaction with ErbB-3...
- The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4D J Riese
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
J Biol Chem 271:20047-52. 1996..Therefore, EGF, TGF-alpha, AR, and HB-EGF are functionally identical in this model system and behave differently from the EGF family hormones betacellulin and neuregulins...
- Gcm1, a mammalian homolog of Drosophila glial cells missingY Altshuller
Department of Pharmacological Sciences, State University of New York, Stony Brook 11794 8651, USA
FEBS Lett 393:201-4. 1996..Mouse Gcm1 demonstrates extensive similarity to Drosophila gcm but is expressed at very low levels during neuro- and gliogenesis...
- Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) geneJ Schmitt
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Genomics 32:358-66. 1996..Ribonuclease protection analyses reveal that mouse Inhbc is predominantly expressed in adult liver. Embryonic expression is detected beginning from Day 14.5 of gestation...
- neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNSL Sommer
Division of Biology 216 76, California Institute of Technology, Pasadena, California, 91125, USA
Mol Cell Neurosci 8:221-41. 1996..The ngn's therefore represent both a family of putative mammalian neuronal determination genes and useful markers of the origins of neuronal diversity...
- Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteinsX Liao
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
Oncogene 14:1023-9. 1997..Evi5 thus encodes a gene separate from Gfi1 that may also be involved in T-cell disease...
- Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinasesK L Carraway
Department of Cell Biology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215, USA
Nature 387:512-6. 1997..Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases...
- Bivalence of EGF-like ligands drives the ErbB signaling networkE Tzahar
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
EMBO J 16:4938-50. 1997..Thus, ligand bivalence enables signal diversification through selective recruitment of homo- and heterodimers of ErbB receptors, and it may explain oncogenicity of erbB-2/HER2...
- The erbB/HER type 1 tyrosine kinase receptor familyR A Walker
J Pathol 185:234-5. 1998..The different distributions could be of particular importance in cancer if therapeutic modalities are identified to inhibit or stimulate the different ligands...
- Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4J P Golding
Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nat Cell Biol 2:103-9. 2000Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons...
- Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junctionA K Fu
Department of Biochemistry, Biotechnology Research Institute, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Nat Neurosci 4:374-81. 2001..Taken together, these results reveal the unexpected involvement of Cdk5/p35 in neuregulin signaling at the neuromuscular synapse...
- Regulation of the ErbB3 binding protein Ebp1 by protein kinase CT J Lessor
Molecular and Cellular Biology Program, University of Maryland, Baltimore, MD 21201, USA
Mol Cell Endocrinol 175:185-91. 2001Ebp1, a 47 kDa ubiquituously expressed protein, binds the ErbB3 receptor in human serum starved breast cancer cell lines and dissociates from ErbB3 on treatment with the ErbB3 ligand, Heregulin (HRG)...
- Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancyS O'Shea
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
Am J Pathol 158:1871-80. 2001Mice heterozygous (+/-) for either heregulin (HRG), ErbB2, or ErbB3 were created by gene targeting, resulting in the loss of one functional gene copy and an associated decrease in targeted protein...
- A role for neuregulin1 signaling in muscle spindle differentiationSimon Hippenmeyer
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056, Basel, Switzerland
Neuron 36:1035-49. 2002....
- Essential roles of Meltrin beta (ADAM19) in heart developmentKazuto Kurohara
Department of Growth Regulation, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
Dev Biol 267:14-28. 2004..These results suggest the necessity of proteolytic regulation of ErbB ligands by Meltrin beta for proper heart development...
- Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouseNaoko Brown
Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2370, USA
Biol Reprod 71:2003-11. 2004..We also observed upregulation of the erbB2 and erbB3 receptors at the blastocyst stage of embryo development...
- Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNSGeraldine S Maro
Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
Nat Neurosci 7:930-8. 2004..These data indicate that BC cells constitute a source of peripheral nervous system (PNS) components that, after the major neural crest ventrolateral migratory stream, feeds a secondary wave of migration to the PNS...
- Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathwayJinbo Liu
Department of Internal Medicine, Pulmonary and Critical Care Division, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
Exp Lung Res 30:465-78. 2004..through the activation of its receptor, a heterodimer of human epidermal growth factor receptors 2 and 3 (HER2/HER3)...
- Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in miceDavid E Nethery
Dept of Internal Medicine, Pulmonary and Critical Care Division, Univ Hospitals of Cleveland, Cleveland, OH 44106, USA
J Appl Physiol (1985) 99:298-307. 2005Neuregulin-1 (NRG-1), binding to the human epidermal growth factor receptor HER2/HER3, plays a role in pulmonary epithelial cell proliferation and recovery from injury in vitro...
- FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasionNaciba Benlimame
Department of Medicine, Lady Davis Institute of the Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
J Cell Biol 171:505-16. 2005..This colocalization requires intact FAK. In summary, distinct FAK signaling has an essential function in ErbB-induced oncogenesis and invasiveness...
- Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgeneZhe Li
Department of Genetics and Development, Genome Center and Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
Carcinogenesis 27:1054-67. 2006..PIN and CAP, led to the identification of some novel biomarkers and also revealed increased expression of Egfr, Erbb3 and phosphorylated androgen receptor...
- Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndromeTom Van de Putte
Laboratory of Molecular Biology Celgen, KULeuven, Herestraat 49, B 3000 Leuven, Belgium
Hum Mol Genet 16:1423-36. 2007....
- Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryosJ Dackor
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Placenta 28:1211-8. 2007..Immunohistochemical analysis of ERBB family receptors, ERBB2, ERBB3, and ERBB4, showed similar expression between Egfr wildtype and null placentas indicating that Egfr null ..
- Dynamic expression of Erbb pathway members during early mammary gland morphogenesisOlivia Wansbury
The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
J Invest Dermatol 128:1009-21. 2008..The Neuregulin ligands, Nrg1, Nrg2, Nrg3, Nrg4 and the receptors, Erbb1, Erbb2, Erbb3, Erbb4, were expressed either at stages prior to morphological appearance of the mammary placode or from the time ..
- Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindlesTadasuke Komori
Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
J Comp Neurol 511:92-108. 2008....
- A Sox10 expression screen identifies an amino acid essential for Erbb3 functionKristina Buac
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 4:e1000177. 2008..Linkage analysis, sequencing, and complementation testing confirmed that msp1 is a new allele of the receptor tyrosine kinase Erbb3, Erbb3(msp1), that carries a single amino acid substitution in the extracellular region of the ..
- NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferationKristina Buac
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Pigment Cell Melanoma Res 22:773-84. 2009Neuregulin (NRG) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression...
- Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of CortiIngrid Breuskin
GIGA Neurosciences, University of Liege, Belgium
Dev Biol 335:327-39. 2009..Evidence also suggests that this effect occurs via the activation of the Jagged1 gene...
- Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient miceKei Ichi Katayama
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
PLoS ONE 4:e7786. 2009..These results suggest that Slitrk6 promotes innervation and survival of inner ear sensory neurons by regulating the expression of trophic and/or tropic factors including neurotrophins from sensory epithelia...
- Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10Ingrid Breuskin
GIGA Neurosciences, University of Liege, Liege, Belgium
J Neurochem 114:1827-39. 2010..Taken together, these data suggest that in the absence of neural crest-derived glial cells, an increase trophic support from hair cells promotes the survival of spiral ganglion neurons in Sox10 mutant mice...
- Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancerK Sakamoto
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
Oncogene 29:5359-69. 2010..PRL-induced mammary cancers exhibited an upregulation of ErbB2 and other ErbB receptor tyrosine kinases that may supersede the functionality of PRLR signaling through Jak2...
- ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cellsS R Krig
Department of Biochemistry and Molecular Medicine, Divison of Basic Sciences, University of California at Davis Cancer Center, Sacramento, CA 95817, USA
Oncogene 29:5500-10. 2010Understanding the mechanisms underlying ErbB3 overexpression in breast cancer will facilitate the rational design of therapies to disrupt ErbB2-ErbB3 oncogenic function...
- Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteinsAli Mukherjee
Department of Oncology, Monogram Biosciences, South San Francisco, California, United States of America
PLoS ONE 6:e16443. 2011..b>HER3 signaling through heterodimerization is an important growth-promoting mechanism in several tumor types and may be a ..
- XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytesRowena Lavery
Inserm U636, Nice, France
Dev Biol 354:111-22. 2011..Taken together, we found that XY Sf1:Cre(Tg/+); Sox9(flox/flox) females are capable of producing viable offspring albeit at a reduced level...
- Chronic β-adrenergic stimulation increases ErbB receptors and cell proliferation in mouse kidneyGenis Camprecios
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Catalonia, Spain
Growth Factors 29:94-101. 2011..ErbB1 (epidermal growth factor receptor) along with ErbB2 and ErbB3 (neuregulin receptor) were transiently overexpressed in ISO-treated mice, with an increase in protein but not mRNA ..
- Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signalingAndrew Tri Van Ho
UPMC Paris 06, UMR S 787, F 75013 Paris, France
Dev Cell 21:273-87. 2011..We show that reduced NCC-derived Neuregulin1 (Nrg1) in the somite region perturbs ErbB3 signaling in uncommitted MPCs...
- Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal developmentR Kramer
Department of Molecular Biology, Amgen Center, Thousand Oaks, CA 91320 1789, USA
Proc Natl Acad Sci U S A 93:4833-8. 1996..The trigeminal ganglion is reduced in size and lacks projections toward the brain stem and mandible. We conclude that IgL-domain-containing neuregulins play a major role in cardiac and neuronal development...
- Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somiteJ A McMahon
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA amcmahon biosun harvar d edu
Genes Dev 12:1438-52. 1998..Together these data demonstrate that inhibition of BMP signaling by axially secreted Noggin is an important requirement for normal patterning of the vertebrate neural tube and somite...
- Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heartM M Lakkis
Cardiology Division, Department of Medicine and the Department of Cell and Molecular Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Development 125:4359-67. 1998..These results indicate that neurofibromin normally acts to modulate epithelial-mesenchymal transformation and proliferation in the developing heart by down regulating ras activity...
- The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migrationR H Adams
European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Cell 104:57-69. 2001..Our results indicate distinct requirements of functions mediated by the ephrinB carboxyterminus for developmental processes in the vertebrate embryo...
- Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activatorS D Bamforth
Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Center for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN UK
Nat Genet 29:469-74. 2001..We find increased apoptosis in the midbrain region and a marked reduction in ErbB3-expressing neural crest cells in mid-embryogenesis...
- Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during developmentC Le Moine
UMR CNRS 5541, Laboratoire d Histologie Embryologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
Neuroscience 112:131-9. 2002....
- Regulation of Angiogenesis by C CAM1Sue Hwa Lin; Fiscal Year: 2004..Achieving these aims will provide valuable information for applying CCAM1 for prostate cancer therapy and for developing C-CAM1 combination therapy. ..
- Bone Metastasis Factor-1 in Prostate Cancer/Bone InteractionSue Hwa Lin; Fiscal Year: 2009..Investigate the mechanism of MDA-BF-1-mediated osteoblast proliferation and differentiation;and Aim 3. Purify, identify, and clone the receptor for MDA-BF-1 (BF1-receptor). ..