Erbb3

Summary

Gene Symbol: Erbb3
Description: erb-b2 receptor tyrosine kinase 3
Alias: C76256, Erbb-3, Erbb3r, Her3, receptor tyrosine-protein kinase erbB-3, avian erythroblastosis oncogene B 3 receptor, c-erbB-3, glial growth factor receptor, proto-oncogene-like protein c-ErbB-3, receptor tyrosine kinase, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
Species: mouse

Top Publications

  1. ncbi The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions
    I Alroy
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    FEBS Lett 410:83-6. 1997
  2. ncbi Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions
    Irina J Fox
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 79:584-97. 2005
  3. ncbi Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer
    Clodia Osipo
    Department of Pathology, Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Medical Center, Maywood, IL, USA
    Int J Oncol 30:509-20. 2007
  4. pmc Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
  5. pmc A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal
    Janna Merte
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 30:5767-75. 2010
  6. pmc Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation
    Marion A Cooley
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    Dev Dyn 241:303-14. 2012
  7. doi Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development
    M Cristina Ortega
    Grupo de Neurobiología del Desarrollo GNDe, Hospital Nacional de Paraplejicos, Toledo, Spain
    Exp Neurol 235:610-20. 2012
  8. ncbi Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses
    D Wolpowitz
    Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
    Neuron 25:79-91. 2000
  9. pmc Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors
    M H Kraus
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 86:9193-7. 1989
  10. ncbi Multiple essential functions of neuregulin in development
    D Meyer
    Nature 378:386-90. 1995

Research Grants

Scientific Experts

  • Yan Zhu
  • Lawrence A Scheving
  • Shimian Qu
  • S R Krig
  • Daekee Lee
  • Per Svensson
  • Tom Van de Putte
  • Sue Hwa Lin
  • Marie P Piechocki
  • Stacie K Loftus
  • Ali Mukherjee
  • Aeree Kim
  • Päivi J Miettinen
  • Fang Xu Jiang
  • S L Erickson
  • Junji Yamauchi
  • R Gerlai
  • D J Henderson
  • Todd D Camenisch
  • Carmen Birchmeier
  • Thomas Muller
  • Genis Camprecios
  • Ingrid Breuskin
  • Kristina Buac
  • Rebecca S Cook
  • Igor Adameyko
  • William J Muller
  • Bastian G Brinkmann
  • Mohamed Mlih
  • Xiaoling Song
  • Vyacheslav Dyachuk
  • Maria E Sheean
  • Christoph Gerhardt
  • Erez Nitzan
  • Mayumi Nagashimada
  • Nicolas Jullien
  • Manabu Makinodan
  • Zheping Huang
  • Hicham Lahlou
  • Marion A Cooley
  • Shyuan T Ngo
  • David B Vaught
  • Li Chen
  • M Cristina Ortega
  • Cammie Rinehart
  • Carlos L Arteaga
  • Jamie C Stanford
  • Patrik Ernfors
  • Christian Young
  • Violeta Sanchez
  • Ignasi Ramirez
  • Maria Soley
  • Alistair N Garratt
  • Rowena Lavery
  • Andrew Tri Van Ho
  • K Sakamoto
  • Janna Merte
  • Victoria E Abraira
  • A Meixner
  • Morgan Bodson
  • Philippe P Lefebvre
  • Marc Thiry
  • Nicolas Thelen
  • Brigitte Malgrange
  • Laurence Borgs
  • Laurent Nguyen
  • Satoshi Kawano
  • Shih Chu Kao
  • Y Abe
  • C Birchmeier
  • S Britsch
  • Kei Ichi Katayama
  • William J Pavan
  • Olivia Wansbury
  • Si Tuen Lee-Hoeflich
  • Tadasuke Komori
  • Marie Christine Chaboissier
  • Sandra Niendorf
  • L Sommer
  • J Dackor
  • Alleda E Flagg
  • Clodia Osipo
  • Piotr Topilko
  • D Riethmacher
  • Markus H Schwab
  • Tobias M Fischer
  • Cary Lai
  • Zhe Li
  • Klaus Armin Nave
  • Michael W Sereda

Detail Information

Publications115 found, 100 shown here

  1. ncbi The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions
    I Alroy
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    FEBS Lett 410:83-6. 1997
    ..The resulting signaling network has important implications for embryonic development and malignant transformation...
  2. ncbi Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions
    Irina J Fox
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 79:584-97. 2005
    The ErbB family, ErbB1 (also known as the epidermal growth factor receptor EGFR), ErbB2, ErbB3, and ErbB4 comprise a group of receptor tyrosine kinases that interact with ligands from the epidermal growth factor (EGF) superfamily, ..
  3. ncbi Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer
    Clodia Osipo
    Department of Pathology, Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Medical Center, Maywood, IL, USA
    Int J Oncol 30:509-20. 2007
    ..However, tyrosine-phosphorylated HER2/ neu, HER3, phospho-extracellular-regulated kinase-1/2 (ERK-1/2), and phospho-glycogen synthetase kinase 3alpha (GSK3alpha) ..
  4. pmc Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
    ..Unexpectedly, these mice assemble normal amounts of myelin. In addition, double mutants lacking oligodendroglial ErbB3 and ErbB4 become myelinated in the absence of any stimulation by neuregulins...
  5. pmc A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal
    Janna Merte
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 30:5767-75. 2010
    ..Therefore, through the use of a forward-genetic screen we have identified a novel allele of Sema3A that provides structural insight into the mechanism of Sema3A/Npn-1/PlexinA signaling...
  6. pmc Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation
    Marion A Cooley
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    Dev Dyn 241:303-14. 2012
    ..Here we investigated the involvement of fibulin-1 in ADAMTS1-mediated cleavage of versican in vitro, and the involvement of fibulin-1 in versican cleavage in ventricular morphogenesis...
  7. doi Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development
    M Cristina Ortega
    Grupo de Neurobiología del Desarrollo GNDe, Hospital Nacional de Paraplejicos, Toledo, Spain
    Exp Neurol 235:610-20. 2012
    ..The present findings reveal a new role for Nrg1/ErbB4 signaling in regulating OPC migration selectively during early stages of CNS development...
  8. ncbi Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses
    D Wolpowitz
    Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
    Neuron 25:79-91. 2000
    ....
  9. pmc Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors
    M H Kraus
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 86:9193-7. 1989
    ..with structural features identifying it as a member of the ERBB gene family, prompting us to designate the gene as ERBB3. It was mapped to human chromosome 12q13 and was shown to be expressed as a 6...
  10. ncbi Multiple essential functions of neuregulin in development
    D Meyer
    Nature 378:386-90. 1995
    ..The biological effects of the factor are mediated by tyrosine kinase receptors. Neuregulin can bind directly to erbB3 and erbB4 and receptor heterodimerization allows neuregulin-dependent activation of erbB2 (refs 1, 2, 5)...
  11. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
    ..Mice heterozygous for the ptc mutation were larger than normal, and a subset of them developed hindlimb defects or cerebellar medulloblastomas, abnormalities also seen in BCNS patients...
  12. ncbi Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
    D Riethmacher
    Department of Medical Genetics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nature 389:725-30. 1997
    ..Here we use gene targeting to generate mice that lack ErbB3, a high-affinity neuregulin receptor...
  13. ncbi Isoform-specific expression and function of neuregulin
    D Meyer
    Max Delbruck Center for Molecular Medicine, Department of Medical Genetics, Berlin, Germany
    Development 124:3575-86. 1997
    ..The complexity of neuregulin functions in development is therefore due to independent roles played by distinct isoforms...
  14. ncbi ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice
    S L Erickson
    Department of Molecular Biology, Genetech Inc, South San Francisco, California 94080, USA
    Development 124:4999-5011. 1997
    Heregulins bind directly to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor...
  15. ncbi Specificity within the EGF family/ErbB receptor family signaling network
    D J Riese
    Department of Pathology, Yale University, New Haven, CT, USA
    Bioessays 20:41-8. 1998
    ..family hormones can activate receptors in trans, and this heterodimerization diversifies biological responses; 5) ErbB3 requires a receptor partner for signaling; and 6) ErbB family receptors differentially couple to signaling ..
  16. ncbi erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation
    H Lim
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas, 66160 7338, USA
    Dev Biol 204:97-110. 1998
    ..No information is available about uterine and embryonic status of ErbB3 or ErbB4 during implantation...
  17. pmc Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer
    P M Siegel
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    EMBO J 18:2149-64. 1999
    ....
  18. ncbi Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors
    P J Miettinen
    Department of Pathology and Transplantation Laboratory, The Haartman Institute, and Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Development 127:2617-27. 2000
    ..Upregulated PAI-1 production and decreased gelatinolytic activity correlated to this migration defect. An intact EGF-R pathway appears to be a prerequisite for normal pancreatic development...
  19. pmc The transcription factor Sox10 is a key regulator of peripheral glial development
    S Britsch
    Max Delbruck Center for Molecular Medicine, D 13122 Berlin, Germany
    Genes Dev 15:66-78. 2001
    ..Moreover, we show that Sox10 controls expression of ErbB3 in neural crest cells...
  20. ncbi Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant
    D J Henderson
    Neural Development Unit, Institute of Child Health, University College London, London UK
    Circ Res 89:6-12. 2001
    ..We suggest that the double-sided arch arises as a primary defect in the Lp mutant, unrelated to the alignment defects, perhaps reflecting a role for the (as-yet-unknown) Lp gene in maintenance/regression of the aortic arch system...
  21. ncbi Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling
    C Paratore
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Development 128:3949-61. 2001
    ..Failures in fate decision processes might thus contribute to the etiology of Waardenburg/Hirschsprung disease...
  22. ncbi Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors
    Todd D Camenisch
    College of Pharmacy and Steele Memorial Children s Research Center, University of Arizona, Tucson, Arizona, USA
    Nat Med 8:850-5. 2002
    ..lack mesenchyme formation, are rescued by heregulin treatment, which restores phosphorylation of ErbB2 and ErbB3. These events were blocked using a soluble ErbB3 molecule, as well as with an inhibitor of ErbB2, herstatin...
  23. ncbi Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland
    Yuji Miyazaki
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
    Dev Dyn 230:591-6. 2004
    ..Here, we report on the neuregulin (NRG) -1 protein and its receptors ErbB2 and ErbB3 in the developing SMG...
  24. ncbi Gene targeting of ErbB3 using a Cre-mediated unidirectional DNA inversion strategy
    Shimian Qu
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6838, USA
    Genesis 44:477-86. 2006
    ..To test the feasibility of this strategy we targeted ErbB3, a member of the ErbB family of tyrosine kinase receptors, using this strategy...
  25. pmc Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation
    Shih Chu Kao
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Science 323:651-4. 2009
    ..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells...
  26. pmc Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium
    Daekee Lee
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Invest 119:2702-13. 2009
    ..Although the upregulation of ERBB3, a pseudo-kinase member of the EGFR/ERBB family, is known to contribute to EGFR inhibitor resistance in other ..
  27. pmc Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells
    Aeree Kim
    Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK, USA
    Breast Cancer Res 7:R708-18. 2005
    Co-expression of several receptor tyrosine kinases (RTKs), including erbB2 and erbB3, is frequently identified in breast cancers...
  28. pmc Identification of ErbB3-stimulated genes using modified representational difference analysis
    C F Edman
    Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA 92093 0684, U S A
    Biochem J 323:113-8. 1997
    ..used a PCR-based subtractive approach to identify differences in messages induced in response to activation of ErbB3 and EGFR...
  29. pmc The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system
    S Britsch
    Department of Medical Genetics, Max Delbruck Center MDC for Molecular Medicine, 13122 Berlin, Germany
    Genes Dev 12:1825-36. 1998
    ..Here, we report a novel phenotype in mice with targeted mutations in the erbB2, erbB3, or neuregulin-1 genes. These three mutations cause a severe hypoplasia of the primary sympathetic ganglion chain...
  30. ncbi The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
    Nature 399:366-70. 1999
    ....
  31. ncbi Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea
    Hang Zhou
    Division of Hematology Oncology and Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, OH 44106 4937, USA
    Oncogene 21:8732-40. 2002
    ..This erb-B-3 mouse lung cancer model will help dissect genetic changes in lung tumorigenesis and may be useful for chemoprevention studies...
  32. ncbi Molecular markers of cardiac endocardial cushion development
    Aaron D Gitler
    Department of Medicine, Cardiology Division, University of Pennsylvania Health System, 954 BRB II III, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 228:643-50. 2003
    ....
  33. ncbi Axonal neuregulin-1 regulates myelin sheath thickness
    Galin V Michailov
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Science 304:700-3. 2004
    ..We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size...
  34. pmc Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo
    Sandra Niendorf
    Leibniz Institut fur Molekulare Pharmakologie, Krahmerstr 6, D 12207 Berlin, Germany
    Mol Cell Biol 27:5029-39. 2007
    ..tyrosine kinases (RTKs), like epidermal growth factor receptor, hepatocyte growth factor receptor (c-met), and ERBB3. UBPy-deficient cells exhibit aberrantly enlarged early endosomes colocalizing with enhanced ubiquitination and ..
  35. doi In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons
    Y Abe
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Chuo Ku, Niigata 951 8585, Japan
    Neuroscience 161:95-110. 2009
    ..Modest signal for ErbB1 mRNA was also detected in a subset of dopaminergic neurons. ErbB3 mRNA was detectable at postnatal day 10, peaked at postnatal day 18, and colocalized with 2',3'-cyclic nucleotide ..
  36. doi Jun and JunD-dependent functions in cell proliferation and stress response
    A Meixner
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
    Cell Death Differ 17:1409-19. 2010
    ....
  37. pmc ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis
    Rebecca S Cook
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 71:3941-51. 2011
    The ErbB receptor family member ErbB3 has been implicated in breast cancer growth, but it has yet to be determined whether its disruption is therapeutically valuable...
  38. doi Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylation
    Shyuan T Ngo
    School of Biomedical Sciences, University of Queensland, St Lucia, 4072, Queensland, Australia
    J Cell Sci 125:1531-43. 2012
    ..Thus two classic synaptic signalling systems (neuregulin-1 and n-agrin) converge upon MuSK to regulate postsynaptic differentiation...
  39. doi Uncoupling of PI3K from ErbB3 impairs mammary gland development but does not impact on ErbB2-induced mammary tumorigenesis
    Hicham Lahlou
    Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Cancer Res 72:3080-90. 2012
    The formation of ErbB2/ErbB3 heterodimers plays a critical role in ErbB2-mediated signaling in both normal mammary development and mammary tumor progression...
  40. pmc Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3
    Erez Nitzan
    Department of Medical Neurobiology, IMRIC and ELSC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 110:12709-14. 2013
    ..Together, we propose that differential fate acquisition of neural crest-derived cells depends on their progressive segregation from the Foxd3-positive lineage. ..
  41. pmc Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination
    Maria E Sheean
    Developmental Biology Signal Transduction
    Genes Dev 28:290-303. 2014
    ..Previous work demonstrated that loss of ErbB3/Shp2 signaling impairs Schwann cell development and disrupts the myelination program...
  42. doi Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors
    Vyacheslav Dyachuk
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden A V Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
    Science 345:82-7. 2014
    ..This nerve origin places cellular elements for generating parasympathetic neurons in diverse tissues and organs, which may enable wiring of the developing parasympathetic nervous system...
  43. pmc The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development
    Mohamed Mlih
    From the CNRS, UMR 7213, University of Strasbourg, 67401 Illkirch, France
    J Biol Chem 290:2419-30. 2015
    ..We find that not only the ErbB3/Neuregulin signaling pathway but also the baroreceptor reflex response, which have been functionally associated, ..
  44. pmc ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas
    Xiaoling Song
    Department of Pathology and Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut
    Cancer Res 75:1035-45. 2015
    b>ERBB3, a member of the EGFR family of receptor tyrosine kinases, has been implicated in activation of the PI3K pathway in human lung adenocarcinomas driven by EGFR mutations...
  45. ncbi Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks
    R Gerlai
    Department of Neuroscience, Genentech Incorporated, Mail Stop 72, 1 DNA Way, South, San Francisco, CA 94080 4990, USA
    Behav Brain Res 109:219-27. 2000
    ..To investigate this the heregulin-1, ErbB2, or ErbB3 locus was disrupted in a targeted manner and mice heterozygous for the mutation were analyzed...
  46. ncbi erbB3 is dispensable for oligodendrocyte development in vitro and in vivo
    Johannes Schmucker
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Hamburg, Germany
    Glia 44:67-75. 2003
    During development and in the adult, erbB2, erbB3, and erbB4 are expressed in many tissues and as heterodimers (B2/B3, B2/B4) serve as receptors for neuregulins...
  47. pmc Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6502-7. 2004
    ..Further, Sox9-deficient endocardial mesenchymal cells fail to express ErbB3, which is required for endocardial cushion cell differentiation and proliferation...
  48. ncbi Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation
    Fang Xu Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Differentiation 73:45-9. 2005
    ..5 pancreatic cells to proliferate and form cystoid and solid colonies. These results demonstrate that laminin-1 and EGF signaling pathways interact to promote pancreas development...
  49. pmc Comparison of melanoblast expression patterns identifies distinct classes of genes
    Stacie K Loftus
    National Institutes of Health, National Human Genome Research Institute, Genetic Disease Research Branch, Bethesda, MD, USA
    Pigment Cell Melanoma Res 22:611-22. 2009
    ....
  50. pmc Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis
    Victoria E Abraira
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e8981. 2010
    ..In addition, other receptor tyrosine kinase binding partners have been identified for both Lrig1 and Lrig3, leaving open the question of whether ..
  51. doi Expression, localization, and regulation of the neuregulin receptor ErbB3 in mouse heart
    Genis Camprecios
    Faculty of Biology, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Catalonia, Spain
    J Cell Physiol 226:450-5. 2011
    ..However, here we show the presence of ErbB3 in the mouse heart from birth to adulthood by Western blotting and real-time RT-PCR...
  52. doi Downregulation of ErbB3 by Wnt3a contributes to wnt-induced osteoblast differentiation in mesenchymal cells
    Nicolas Jullien
    INSERM U606, University Paris Diderot, and Hospital Lariboisière, Paris, France
    J Cell Biochem 113:2047-56. 2012
    ..is upregulated by Wnt3a, and that this effect was counterbalanced by decreased expression of the NRG-1 receptor ErbB3. Consistently, exogenous NRG-1 had no effect on alkaline phosphatase (ALP) activity, an early marker of osteoblast ..
  53. doi Bone marrow-derived mesenchymal stem cells up-regulate acetylcholine receptor delta subunit through NRG/ErbB3-mediated mitogen-activated protein kinase pathway
    Li Chen
    Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
    Clin Transl Sci 5:27-31. 2012
    ..NRG-1 antibody added in conditional medium of BMSCs, si-ErbB3, and four Ras/Raf/MEK/ERK pathway inhibitors (FTS, Sulindac, U0126, and PD98059) were using to investigate the ..
  54. pmc HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation
    David B Vaught
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Res 72:2672-82. 2012
    Increasing evidence suggests that HER2-amplified breast cancer cells use HER3/ErbB3 to drive therapeutic resistance to HER2 inhibitors. However, the role of ErbB3 in the earliest events of breast epithelial transformation remains unknown...
  55. pmc Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions
    Zheping Huang
    Department of Pediatrics, Women and Infants Hospital of Rhode Island and the Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    J Biol Chem 287:18091-102. 2012
    ..These studies provide novel insights into the cell signaling mechanisms regulating ErbB family receptors in lung cell differentiation...
  56. pmc Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression
    Mayumi Nagashimada
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan
    J Clin Invest 122:3145-58. 2012
    ..Our results also demonstrate that Sox10 regulation by PHOX2B is pivotal for the development and pathogenesis of the autonomic ganglia...
  57. pmc A critical period for social experience-dependent oligodendrocyte maturation and myelination
    Manabu Makinodan
    F M Kirby Neurobiology Center, Children s Hospital, Boston, MA 02115, USA
    Science 337:1357-60. 2012
    ..These alterations, which occur only during this critical period, are phenocopied by loss of oligodendrocyte ErbB3 receptors, and social isolation leads to reduced expression of the ErbB3 ligand neuregulin-1...
  58. pmc The ciliary protein Ftm is required for ventricular wall and septal development
    Christoph Gerhardt
    Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 8:e57545. 2013
    ..Thus, our study suggests ciliopathy as a cause of VSDs...
  59. ncbi Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle
    L M Moscoso
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Biol 172:158-69. 1995
    ..ARIA-responsive myotubes expressed both erbB2 and erbB3, but little EGFR/erbB1 or erbB4. In adults, erbB2 and erbB3 were localized to the postsynaptic membrane...
  60. ncbi ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes
    M Marikovsky
    Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Oncogene 10:1403-11. 1995
    ..We conclude that different isoforms of NDF induce distinct growth regulatory effects on cultured keratinocytes, through direct interaction with ErbB-3...
  61. ncbi The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4
    D J Riese
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 271:20047-52. 1996
    ..Therefore, EGF, TGF-alpha, AR, and HB-EGF are functionally identical in this model system and behave differently from the EGF family hormones betacellulin and neuregulins...
  62. ncbi Gcm1, a mammalian homolog of Drosophila glial cells missing
    Y Altshuller
    Department of Pharmacological Sciences, State University of New York, Stony Brook 11794 8651, USA
    FEBS Lett 393:201-4. 1996
    ..Mouse Gcm1 demonstrates extensive similarity to Drosophila gcm but is expressed at very low levels during neuro- and gliogenesis...
  63. ncbi Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene
    J Schmitt
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Genomics 32:358-66. 1996
    ..Ribonuclease protection analyses reveal that mouse Inhbc is predominantly expressed in adult liver. Embryonic expression is detected beginning from Day 14.5 of gestation...
  64. ncbi neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
    L Sommer
    Division of Biology 216 76, California Institute of Technology, Pasadena, California, 91125, USA
    Mol Cell Neurosci 8:221-41. 1996
    ..The ngn's therefore represent both a family of putative mammalian neuronal determination genes and useful markers of the origins of neuronal diversity...
  65. ncbi Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins
    X Liao
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Oncogene 14:1023-9. 1997
    ..Evi5 thus encodes a gene separate from Gfi1 that may also be involved in T-cell disease...
  66. ncbi Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases
    K L Carraway
    Department of Cell Biology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    Nature 387:512-6. 1997
    ..Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases...
  67. pmc Bivalence of EGF-like ligands drives the ErbB signaling network
    E Tzahar
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 16:4938-50. 1997
    ..Thus, ligand bivalence enables signal diversification through selective recruitment of homo- and heterodimers of ErbB receptors, and it may explain oncogenicity of erbB-2/HER2...
  68. ncbi The erbB/HER type 1 tyrosine kinase receptor family
    R A Walker
    J Pathol 185:234-5. 1998
    ..The different distributions could be of particular importance in cancer if therapeutic modalities are identified to inhibit or stimulate the different ligands...
  69. ncbi Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4
    J P Golding
    Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Cell Biol 2:103-9. 2000
    Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons...
  70. ncbi Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction
    A K Fu
    Department of Biochemistry, Biotechnology Research Institute, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Nat Neurosci 4:374-81. 2001
    ..Taken together, these results reveal the unexpected involvement of Cdk5/p35 in neuregulin signaling at the neuromuscular synapse...
  71. ncbi Regulation of the ErbB3 binding protein Ebp1 by protein kinase C
    T J Lessor
    Molecular and Cellular Biology Program, University of Maryland, Baltimore, MD 21201, USA
    Mol Cell Endocrinol 175:185-91. 2001
    Ebp1, a 47 kDa ubiquituously expressed protein, binds the ErbB3 receptor in human serum starved breast cancer cell lines and dissociates from ErbB3 on treatment with the ErbB3 ligand, Heregulin (HRG)...
  72. pmc Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy
    S O'Shea
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    Am J Pathol 158:1871-80. 2001
    Mice heterozygous (+/-) for either heregulin (HRG), ErbB2, or ErbB3 were created by gene targeting, resulting in the loss of one functional gene copy and an associated decrease in targeted protein...
  73. ncbi A role for neuregulin1 signaling in muscle spindle differentiation
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056, Basel, Switzerland
    Neuron 36:1035-49. 2002
    ....
  74. ncbi Essential roles of Meltrin beta (ADAM19) in heart development
    Kazuto Kurohara
    Department of Growth Regulation, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Dev Biol 267:14-28. 2004
    ..These results suggest the necessity of proteolytic regulation of ErbB ligands by Meltrin beta for proper heart development...
  75. ncbi Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse
    Naoko Brown
    Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2370, USA
    Biol Reprod 71:2003-11. 2004
    ..We also observed upregulation of the erbB2 and erbB3 receptors at the blastocyst stage of embryo development...
  76. ncbi Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS
    Geraldine S Maro
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Nat Neurosci 7:930-8. 2004
    ..These data indicate that BC cells constitute a source of peripheral nervous system (PNS) components that, after the major neural crest ventrolateral migratory stream, feeds a secondary wave of migration to the PNS...
  77. ncbi Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway
    Jinbo Liu
    Department of Internal Medicine, Pulmonary and Critical Care Division, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Exp Lung Res 30:465-78. 2004
    ..through the activation of its receptor, a heterodimer of human epidermal growth factor receptors 2 and 3 (HER2/HER3)...
  78. ncbi Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice
    David E Nethery
    Dept of Internal Medicine, Pulmonary and Critical Care Division, Univ Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Appl Physiol (1985) 99:298-307. 2005
    Neuregulin-1 (NRG-1), binding to the human epidermal growth factor receptor HER2/HER3, plays a role in pulmonary epithelial cell proliferation and recovery from injury in vitro...
  79. pmc FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion
    Naciba Benlimame
    Department of Medicine, Lady Davis Institute of the Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Cell Biol 171:505-16. 2005
    ..This colocalization requires intact FAK. In summary, distinct FAK signaling has an essential function in ErbB-induced oncogenesis and invasiveness...
  80. ncbi Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene
    Zhe Li
    Department of Genetics and Development, Genome Center and Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
    Carcinogenesis 27:1054-67. 2006
    ..PIN and CAP, led to the identification of some novel biomarkers and also revealed increased expression of Egfr, Erbb3 and phosphorylated androgen receptor...
  81. ncbi Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome
    Tom Van de Putte
    Laboratory of Molecular Biology Celgen, KULeuven, Herestraat 49, B 3000 Leuven, Belgium
    Hum Mol Genet 16:1423-36. 2007
    ....
  82. pmc Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos
    J Dackor
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Placenta 28:1211-8. 2007
    ..Immunohistochemical analysis of ERBB family receptors, ERBB2, ERBB3, and ERBB4, showed similar expression between Egfr wildtype and null placentas indicating that Egfr null ..
  83. ncbi Dynamic expression of Erbb pathway members during early mammary gland morphogenesis
    Olivia Wansbury
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Invest Dermatol 128:1009-21. 2008
    ..The Neuregulin ligands, Nrg1, Nrg2, Nrg3, Nrg4 and the receptors, Erbb1, Erbb2, Erbb3, Erbb4, were expressed either at stages prior to morphological appearance of the mammary placode or from the time ..
  84. doi Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles
    Tadasuke Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
    J Comp Neurol 511:92-108. 2008
    ....
  85. pmc A Sox10 expression screen identifies an amino acid essential for Erbb3 function
    Kristina Buac
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 4:e1000177. 2008
    ..Linkage analysis, sequencing, and complementation testing confirmed that msp1 is a new allele of the receptor tyrosine kinase Erbb3, Erbb3(msp1), that carries a single amino acid substitution in the extracellular region of the ..
  86. pmc NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation
    Kristina Buac
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Pigment Cell Melanoma Res 22:773-84. 2009
    Neuregulin (NRG) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression...
  87. doi Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti
    Ingrid Breuskin
    GIGA Neurosciences, University of Liege, Belgium
    Dev Biol 335:327-39. 2009
    ..Evidence also suggests that this effect occurs via the activation of the Jagged1 gene...
  88. pmc Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice
    Kei Ichi Katayama
    Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    PLoS ONE 4:e7786. 2009
    ..These results suggest that Slitrk6 promotes innervation and survival of inner ear sensory neurons by regulating the expression of trophic and/or tropic factors including neurotrophins from sensory epithelia...
  89. doi Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10
    Ingrid Breuskin
    GIGA Neurosciences, University of Liege, Liege, Belgium
    J Neurochem 114:1827-39. 2010
    ..Taken together, these data suggest that in the absence of neural crest-derived glial cells, an increase trophic support from hair cells promotes the survival of spiral ganglion neurons in Sox10 mutant mice...
  90. pmc Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
    K Sakamoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Oncogene 29:5359-69. 2010
    ..PRL-induced mammary cancers exhibited an upregulation of ErbB2 and other ErbB receptor tyrosine kinases that may supersede the functionality of PRLR signaling through Jak2...
  91. pmc ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
    S R Krig
    Department of Biochemistry and Molecular Medicine, Divison of Basic Sciences, University of California at Davis Cancer Center, Sacramento, CA 95817, USA
    Oncogene 29:5500-10. 2010
    Understanding the mechanisms underlying ErbB3 overexpression in breast cancer will facilitate the rational design of therapies to disrupt ErbB2-ErbB3 oncogenic function...
  92. pmc Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins
    Ali Mukherjee
    Department of Oncology, Monogram Biosciences, South San Francisco, California, United States of America
    PLoS ONE 6:e16443. 2011
    ..b>HER3 signaling through heterodimerization is an important growth-promoting mechanism in several tumor types and may be a ..
  93. doi XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes
    Rowena Lavery
    Inserm U636, Nice, France
    Dev Biol 354:111-22. 2011
    ..Taken together, we found that XY Sf1:Cre(Tg/+); Sox9(flox/flox) females are capable of producing viable offspring albeit at a reduced level...
  94. doi Chronic β-adrenergic stimulation increases ErbB receptors and cell proliferation in mouse kidney
    Genis Camprecios
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Catalonia, Spain
    Growth Factors 29:94-101. 2011
    ..ErbB1 (epidermal growth factor receptor) along with ErbB2 and ErbB3 (neuregulin receptor) were transiently overexpressed in ISO-treated mice, with an increase in protein but not mRNA ..
  95. doi Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling
    Andrew Tri Van Ho
    UPMC Paris 06, UMR S 787, F 75013 Paris, France
    Dev Cell 21:273-87. 2011
    ..We show that reduced NCC-derived Neuregulin1 (Nrg1) in the somite region perturbs ErbB3 signaling in uncommitted MPCs...
  96. pmc Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development
    R Kramer
    Department of Molecular Biology, Amgen Center, Thousand Oaks, CA 91320 1789, USA
    Proc Natl Acad Sci U S A 93:4833-8. 1996
    ..The trigeminal ganglion is reduced in size and lacks projections toward the brain stem and mandible. We conclude that IgL-domain-containing neuregulins play a major role in cardiac and neuronal development...
  97. pmc Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
    J A McMahon
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA amcmahon biosun harvar d edu
    Genes Dev 12:1438-52. 1998
    ..Together these data demonstrate that inhibition of BMP signaling by axially secreted Noggin is an important requirement for normal patterning of the vertebrate neural tube and somite...
  98. ncbi Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart
    M M Lakkis
    Cardiology Division, Department of Medicine and the Department of Cell and Molecular Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Development 125:4359-67. 1998
    ..These results indicate that neurofibromin normally acts to modulate epithelial-mesenchymal transformation and proliferation in the developing heart by down regulating ras activity...
  99. ncbi The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration
    R H Adams
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Cell 104:57-69. 2001
    ..Our results indicate distinct requirements of functions mediated by the ephrinB carboxyterminus for developmental processes in the vertebrate embryo...
  100. ncbi Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator
    S D Bamforth
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Center for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN UK
    Nat Genet 29:469-74. 2001
    ..We find increased apoptosis in the midbrain region and a marked reduction in ErbB3-expressing neural crest cells in mid-embryogenesis...
  101. ncbi Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during development
    C Le Moine
    UMR CNRS 5541, Laboratoire d Histologie Embryologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Neuroscience 112:131-9. 2002
    ....

Research Grants2

  1. Regulation of Angiogenesis by C CAM1
    Sue Hwa Lin; Fiscal Year: 2004
    ..Achieving these aims will provide valuable information for applying CCAM1 for prostate cancer therapy and for developing C-CAM1 combination therapy. ..
  2. Bone Metastasis Factor-1 in Prostate Cancer/Bone Interaction
    Sue Hwa Lin; Fiscal Year: 2009
    ..Investigate the mechanism of MDA-BF-1-mediated osteoblast proliferation and differentiation;and Aim 3. Purify, identify, and clone the receptor for MDA-BF-1 (BF1-receptor). ..