Epb4.1

Summary

Gene Symbol: Epb4.1
Description: erythrocyte protein band 4.1
Alias: 4.1R, AI415518, D4Ertd442e, Elp-1, Elp1, Epb41, mKIAA4056, P4.1, Protein 4.1R, band 4.1, protein 4.1
Species: mouse

Top Publications

  1. pmc Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b)
    Congrong Liu
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10065, USA
    J Biol Chem 288:11407-15. 2013
  2. pmc Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling
    Adam J Meyer
    Department of Genome Dynamics, University of California, Berkeley, CA 94720, USA
    J Cell Sci 124:1433-44. 2011
  3. pmc Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of beta1 integrin
    Lixiang Chen
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    J Cell Sci 124:2478-87. 2011
  4. doi Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system
    Jennifer C Pinder
    King s College London, Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Exp Cell Res 318:1467-79. 2012
  5. pmc The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons
    Steven Einheber
    School of Health Sciences, Hunter College, City University of New York, New York, New York, USA
    Glia 61:240-53. 2013
  6. pmc Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis
    Jing Liu
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY, USA
    Blood 121:e43-9. 2013
  7. pmc The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding
    Catherine Korsgren
    Division of Hematology Oncology, Department of Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Blood 116:2600-7. 2010
  8. doi Protein 4.1 and the control of ion channels
    Anthony J Baines
    Department of Biosciences, University of Kent, Canterbury, CT2 7NJ Kent, UK
    Blood Cells Mol Dis 42:211-5. 2009
  9. pmc Cytoskeletal protein 4.1R negatively regulates T-cell activation by inhibiting the phosphorylation of LAT
    Qiaozhen Kang
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Blood 113:6128-37. 2009
  10. doi alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells
    Kirian Legendre
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, 25 rue du Dr Roux, 75015 Paris, France
    J Cell Sci 121:3347-56. 2008

Research Grants

  1. GENETIC INTERACTIONS IN RED CELL MEMBRANE DISEASE
    LUANNE PETERS; Fiscal Year: 2003
  2. CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASE
    Alicia Rivera; Fiscal Year: 2003
  3. Hemolytic Anemia: Models
    LUANNE PETERS; Fiscal Year: 2006
  4. Cytokines in Sickle Cell Volume Regulation
    Alicia Rivera; Fiscal Year: 2006
  5. Adducin and the Membrane Skeleton
    LUANNE PETERS; Fiscal Year: 2007
  6. Mouse Models for Heart, Lung and Blood Disease
    LUANNE PETERS; Fiscal Year: 2007
  7. RED CELL CYTOSKELETAL PROTEIN AND MITOSIS
    Shu Ching Huang; Fiscal Year: 2008
  8. ORGANELLE MEMBRANES IN PLATELET STORAGE POOL DISEASE
    LUANNE PETERS; Fiscal Year: 2009

Scientific Experts

  • Alicia Rivera
  • LUANNE PETERS
  • Shu Ching Huang
  • Narla Mohandas
  • Xiuli An
  • Anthony J Baines
  • Shaomin Yang
  • Lixiang Chen
  • Xinhua Guo
  • Jennifer C Pinder
  • Marcela Salomao
  • Gargi Debnath
  • Joel Anne Chasis
  • Lucia De Franceschi
  • Pamela M Taylor-Harris
  • Congrong Liu
  • Steven Einheber
  • Jing Liu
  • Adam J Meyer
  • Youngsin Jung
  • A Kontrogianni-Konstantopoulos
  • JOHN CONBOY
  • Pauline M Bennett
  • Catherine Korsgren
  • Michael D Risley
  • Kazuhiro Okumura
  • Edward Carter
  • Catherine Creppe
  • Qiaozhen Kang
  • Xihui Zhang
  • Alison M Maggs
  • Philippe Gascard
  • Kirian Legendre
  • Mark A Stagg
  • Raymond F Robledo
  • Hongguang Shao
  • Magdi H Yacoub
  • E J Benz
  • Z T Shi
  • Marilyn K Parra
  • Sherry L Gee
  • John G Conboy
  • Victor C Hou
  • N Mohandas
  • Marina Rubin
  • Yelena Ginzburg
  • Huihui Li
  • Isabel Lam
  • Hua Wang
  • Liancheng Wu
  • XIAOSONG MENG
  • JOSEPH KISSIL
  • Fumin Xue
  • Jianhua Zhang
  • Haibao Weng
  • Peter Shrager
  • James L Salzer
  • Patrice Maurel
  • Nandini V L Hayes
  • J G Conboy
  • Mikayala D A King
  • Mark R Holt
  • Richard A Hughes
  • Marilyn Parra
  • Joseph H McCarty
  • Donna K Almendrala
  • Sharon Wald Krauss
  • Joseph L Kissil
  • Amy J Lambert
  • Minjoung M Go
  • Haibo Weng
  • Hiroshi Shitara
  • Samuel E Lux
  • Christopher Clowes
  • Steve D M Brown
  • Hisashi Yamakawa
  • Eiji Mochizuki
  • Ke Chen
  • Jonathan Villalobos
  • Ming Yu
  • Philomena Mburu
  • Yoshiaki Kikkawa
  • Michinari Yokohama
  • Karen Mitchell
  • Hiromichi Yonekawa
  • Kathryn E Hentges
  • Susanne Heck
  • Lina Malinouskaya
  • Cesare Terracciano
  • Gustave Moonen

Detail Information

Publications44

  1. pmc Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b)
    Congrong Liu
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10065, USA
    J Biol Chem 288:11407-15. 2013
    ..1R and the second intracellular loop and C terminus of PMCA1b. Our findings have enabled us to define a functional role for 4.1R in small intestinal calcium absorption through regulation of membrane expression of PMCA1b...
  2. pmc Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling
    Adam J Meyer
    Department of Genome Dynamics, University of California, Berkeley, CA 94720, USA
    J Cell Sci 124:1433-44. 2011
    ....
  3. pmc Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of beta1 integrin
    Lixiang Chen
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    J Cell Sci 124:2478-87. 2011
    ..These data enabled the identification of a functional role for protein 4.1R in keratinocytes by modulating the surface expression of β1 integrin, possibly through a direct association between 4.1R and β1 integrin...
  4. doi Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system
    Jennifer C Pinder
    King s College London, Randall Division of Cell and Molecular Biophysics, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Exp Cell Res 318:1467-79. 2012
    ..We conclude that isoforms of 4.1 proteins are differentially compartmentalised in the heart, and that they form specific complexes with proteins central to cardiomyocyte Ca(2+) metabolism...
  5. pmc The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons
    Steven Einheber
    School of Health Sciences, Hunter College, City University of New York, New York, New York, USA
    Glia 61:240-53. 2013
    ..1B. These results demonstrate that 4.1B is a key cytoskeletal scaffold for axonal adhesion molecules expressed in the juxtaparanodal and internodal domains that unexpectedly regulates myelin sheath thickness...
  6. pmc Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis
    Jing Liu
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY, USA
    Blood 121:e43-9. 2013
    ..The means to quantitate in vivo murine erythropoiesis using our approach will probably have broad application in the study of altered erythropoiesis in various red cell disorders...
  7. pmc The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding
    Catherine Korsgren
    Division of Hematology Oncology, Department of Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Blood 116:2600-7. 2010
    ..1R complex. A model, based on the structure of α-actinin, suggests that the EF domain modulates the function of the ABD and that the C-terminal EF hands (EF(34)) may bind to the linker that connects the ABD to the first spectrin repeat...
  8. doi Protein 4.1 and the control of ion channels
    Anthony J Baines
    Department of Biosciences, University of Kent, Canterbury, CT2 7NJ Kent, UK
    Blood Cells Mol Dis 42:211-5. 2009
    ..A hypothesis to investigate in the future is that differential regulation of 4.1 and ankyrins (e.g. by PIP(2)) allows highly selective control of cell surface accumulation and transport activity of a specific range of ion channels...
  9. pmc Cytoskeletal protein 4.1R negatively regulates T-cell activation by inhibiting the phosphorylation of LAT
    Qiaozhen Kang
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Blood 113:6128-37. 2009
    ..1R display an elevated humoral response to immunization with T cell-dependent antigen. Thus, we have defined a hitherto unrecognized role for 4.1R in negatively regulating T-cell activation by modulating intracellular signal transduction...
  10. doi alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells
    Kirian Legendre
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, 25 rue du Dr Roux, 75015 Paris, France
    J Cell Sci 121:3347-56. 2008
    ..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin...
  11. doi Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart
    Mark A Stagg
    Heart Science Centre, National Heart and Lung Institute, Imperial College London, United Kingdom
    Circ Res 103:855-63. 2008
    ..1R in modulating the functional properties of several cardiac ion transporters with consequences on cardiac electrophysiology and with possible significant roles during normal cardiac function and disease...
  12. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  13. pmc Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane
    Marcela Salomao
    Red Cell Physiology Laboratory and Membrane Biochemistry Laboratory, New York Blood Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:8026-31. 2008
    ....
  14. doi Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity
    Shaomin Yang
    Red Cell Physiology Laboratory, New York Blood Center, 310 East 67th St, New York, NY 10065, USA
    Biochim Biophys Acta 1788:1458-65. 2009
    ..1R in linking the cadherin/catenin complex to the cytoskeleton through its direct interaction with beta-catenin and in regulating the integrity of adherens junction...
  15. pmc Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene
    Shu Ching Huang
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 114:4233-42. 2009
    ..Taken together, our results suggest that 4.1R gene expression involves transcriptional regulation coupled with a complex splicing regulatory network...
  16. doi Protein 4.1 expression in the developing hair cells of the mouse inner ear
    Kazuhiro Okumura
    Department of Bioproduction, Tokyo University of Agriculture, 196, Yasaka, Abashiri, Hokkaido 099 2493, Japan
    Brain Res 1307:53-62. 2010
    ..1 family members play important roles in the development and maintenance of the inner ear hair cells, and that 4.1B may be a member of the myosin XV-whirlin complex that is important for stereocilia maturation...
  17. pmc Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation
    Marcela Salomao
    The Red Cell Physiology Laboratory, The New York Blood Center, New York, NY, USA
    Blood 116:267-9. 2010
    ..We conclude that aberrant protein sorting is one mechanistic basis for protein deficiencies in HE and HS...
  18. doi The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development
    Michael D Risley
    University of Manchester, Faculty of Life Sciences, Manchester, UK
    Dev Biol 342:146-56. 2010
    ..As the Mediator complex is a transcriptional co-activator, our results suggest that Med31 functions to promote the transcription of genes required for embryonic growth and cell proliferation...
  19. doi β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart
    Youngsin Jung
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Dyn 240:271-7. 2011
    ..These data are the first to identify cell adhesion and signaling pathways regulated by αvβ8 integrin and Band 4.1B as essential for normal formation and function of the heart during embryogenesis...
  20. pmc Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility
    Shaomin Yang
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10065, USA
    Mol Cell Biol 31:2276-86. 2011
    ..Additionally, the finding that infertility is present in B6-129 but not on the B6 background suggests the presence of a major modifier gene(s) that influences 4.1G function and is associated with male infertility...
  21. ncbi Genomic structure of the locus encoding protein 4.1. Structural basis for complex combinational patterns of tissue-specific alternative RNA splicing
    J P Huang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    J Biol Chem 268:3758-66. 1993
    ..1 isoform (135 kDa) that is predominantly expressed in nonerythroid tissues. Combinatorial splicing of these exons may generate different isoforms that exhibit complicated tissue-specific expression patterns...
  22. doi Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin
    Catherine Creppe
    GIGA Signal Transduction, University of Liege, C H U Sart Tilman, 4000 Liege, Belgium
    Cell 136:551-64. 2009
    ..Indeed, silencing of its scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons...
  23. ncbi Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes
    Alicia Rivera
    Children s Hospital Boston, Dept of Laboratory Medicine, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 291:C880-6. 2006
    ..1 plays a major role in volume regulation and physiologically downregulates Na/H exchange in mouse erythrocytes. Upregulation of the Na/H exchange is an important contributor to the elevated cell Na content of 4.1(-/-) erythrocytes...
  24. ncbi Sequence, structure and chromosomal localization of Crtm gene encoding mouse cartilage matrix protein and its exclusion as a candidate for murine achondroplasia
    A Aszodi
    Department of Experimental Pathology, University Hospital, Lund, Sweden
    Matrix Biol 16:563-73. 1998
    ..Immunostaining for CMP and sequence of Crtm in cn/cn mice failed to reveal any disease-specific mutations, suggesting that mutations in Crtm do not cause achondroplasia...
  25. ncbi Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells
    S Avraham
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Gene 204:5-16. 1997
    ..The mouse Ptpro gene was mapped to chromosome 4, closely linked to D4Mit16 and Elp1 (elliptocytosis-1), by using genomic DNAs from a (C57BL/6J x Mus spretus)F1 x Mus spretus backcross...
  26. pmc Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice
    T J Vyse
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA
    J Clin Invest 98:1762-72. 1996
    ..Interestingly, a distal chromosome 4 locus, Nba1, was linked with nephritis but not with any of the autoantibodies measured, suggesting that it contributes to renal disease at a checkpoint distal to autoantibody production...
  27. pmc ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration
    R D Palmiter
    Howard Hughes Medical Institute, University of Washington, Seattle 98195 7370, USA
    EMBO J 15:1784-91. 1996
    ..Prolonged exposure of cells expressing ZnT-2 to zinc causes an accretion of intracellular vesicles. We suggest that ZnT-2 protects these cells from zinc toxicity by facilitating zinc transport into an endosomal/lysosomal compartment...
  28. ncbi Asynchronous regulation of splicing events within protein 4.1 pre-mRNA during erythroid differentiation
    F Baklouti
    Department of Internal Medicine, Boyer Center for Molecular Medicine, School of Medicine, Yale University, New Haven, CT
    Blood 87:3934-41. 1996
    ..These findings also show that the splicing of exon 16 alters the intracellular localization of protein 4.1 in MEL cells, and appears to be essential for its targeting to the plasmalemma...
  29. pmc Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice
    C G Drake
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Proc Natl Acad Sci U S A 91:4062-6. 1994
    ..It is of interest that a gene encoding a receptor for tumor necrosis factor maps to the vicinity of this disease-associated gene...
  30. ncbi Structural diversity of band 4.1 superfamily members
    K Takeuchi
    Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Cell Sci 107:1921-8. 1994
    ..In this study, we describe the initial characterization of these new members and discuss the evolution of the band 4.1 superfamily...
  31. ncbi Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrin-actin binding domain of erythroid protein 4.1
    R Winardi
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California 94720, USA
    Blood 86:4315-22. 1995
    ..Moreover, both nucleated amphibian erythrocytes and their enucleated mammalian counterparts express 4.1 isoforms functionally competent for spectrin-actin binding...
  32. ncbi Molecular basis of hereditary elliptocytosis due to protein 4.1 deficiency
    J Conboy
    N Engl J Med 315:680-5. 1986
    ..The chromosomal location of the gene that codes for protein 4.1 suggests that hereditary elliptocytosis in one class of patients with the disorder may be caused by a mutation of this gene...
  33. ncbi Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1
    L D Walensky
    Department of Neuroscience The Johns Hopkins School of Medicine Baltimore, Maryland 21205, USA
    Curr Biol 8:1269-72. 1998
    ..The neurobehavioral findings are consistent with the distribution of 4.1R in the brain, suggesting that 4.1R performs specific functions in the central nervous system...
  34. pmc Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton
    J Conboy
    Proc Natl Acad Sci U S A 83:9512-6. 1986
    ..1. The availability of cloned erythrocyte protein 4.1 cDNA should facilitate the study of the functional characteristics of this protein in erythroid as well as non-erythroid cells...
  35. pmc Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities
    Z T Shi
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Clin Invest 103:331-40. 1999
    ..1R expression is widespread among nonerythroid cells. The 4.1R knockout mice represent a valuable animal model for exploring 4.1R function in nonerythroid cells and for determining pathophysiological sequelae to 4.1R deficiency...
  36. pmc A nonerythroid isoform of protein 4.1R interacts with components of the contractile apparatus in skeletal myofibers
    A Kontrogianni-Konstantopoulos
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 11:3805-17. 2000
    ..All of these observations suggest a topological model whereby 4.1R may play a scaffolding role by anchoring the actomyosin myofilaments and possibly modulating their displacements during contraction/relaxation...
  37. ncbi The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation
    A Kontrogianni-Konstantopoulos
    Department of Medicine, The Johns Hopkins University School of Medicine, University, Baltimore, Maryland 21205, USA
    J Biol Chem 276:20679-87. 2001
    ..1G are distributed underneath the plasma membrane in PC12 cells. Collectively, these observations suggest that brain 4.1R and 4.1G may modulate the membrane mechanical properties of neuronal cells by promoting fodrin/actin association...
  38. pmc Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch
    Victor C Hou
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, CA 94720, USA
    EMBO J 21:6195-204. 2002
    ..These findings demonstrate that natural developmental changes in hnRNP A/B proteins can effect physiologically important switches in pre-mRNA splicing...
  39. ncbi Quantitative trait loci for baseline erythroid traits
    Luanne L Peters
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 17:298-309. 2006
    ..These analyses emphasize the genetic complexity underlying the regulation of erythroid peripheral blood traits in normal populations and suggest that genes not previously recognized as significantly impacting normal erythropoiesis exist...
  40. ncbi Alternative 5' exons and differential splicing regulate expression of protein 4.1R isoforms with distinct N-termini
    Marilyn K Parra
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA 94720, USA
    Blood 101:4164-71. 2003
    ..1R protein isoforms in various cell types is regulated by a novel mechanism requiring coordination between upstream transcription initiation events and downstream alternative splicing events...
  41. ncbi Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure
    Pamela M Taylor-Harris
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London SE1 1UL, UK
    Mamm Genome 16:137-51. 2005
    ..Four genes, EPB41, EPB41L1, EPB41L2, and EPB41L3 encode proteins 4.1R, 4.1N, 4.1G, and 4.1B, respectively...
  42. pmc Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Italy
    Blood 106:1454-9. 2005
    ....
  43. pmc Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross
    Hongguang Shao
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 18:839-51. 2007
    ..The location and type of QTLs detected in this new cross will assist in future efforts to identify the genetic variation that determines the ratio of lean to fat weight as well as body size in mice...
  44. ncbi Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human
    L L Peters
    The Jackson Laboratory, Bar Harbor, Maine, 04609, USA
    Genomics 54:348-50. 1998
    ..In addition to the prototypical red blood cell 4.1R (human gene symbol EPB41,) these include two homologues that are strongly expressed in the brain (4.1N, EPB41L1; and 4...

Research Grants8

  1. GENETIC INTERACTIONS IN RED CELL MEMBRANE DISEASE
    LUANNE PETERS; Fiscal Year: 2003
    ....
  2. CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASE
    Alicia Rivera; Fiscal Year: 2003
    ..It is additionally significant, because it will provide the means for the applicant to establish an independent research career and to become competitive for a tenure-track assistant professional position. ..
  3. Hemolytic Anemia: Models
    LUANNE PETERS; Fiscal Year: 2006
    ..5 isoform in the structure and assembly of the sarcoplasmic reticulum by an in vivo developmental study. ..
  4. Cytokines in Sickle Cell Volume Regulation
    Alicia Rivera; Fiscal Year: 2006
    ..abstract_text> ..
  5. Adducin and the Membrane Skeleton
    LUANNE PETERS; Fiscal Year: 2007
    ..Follow up studies will include electrocardiology and echocardiology. ..
  6. Mouse Models for Heart, Lung and Blood Disease
    LUANNE PETERS; Fiscal Year: 2007
    ..New mouse models will be cryo-preserved in order to maintain their availability. Provision are likewise to maintain all JAX PGA resources beyond the PGA program. ..
  7. RED CELL CYTOSKELETAL PROTEIN AND MITOSIS
    Shu Ching Huang; Fiscal Year: 2008
    ..Finally, we shall define the relationship between changes in the expression of these 4.1R isoforms and the transition from proliferation to post-mitotic states during erythroid differentiation. ..
  8. ORGANELLE MEMBRANES IN PLATELET STORAGE POOL DISEASE
    LUANNE PETERS; Fiscal Year: 2009
    ..Lung fibrosis typically leads to death in the 4th to 5th decades. This study is designed to identify the underlying genetic causes of HPS, which will provide avenues of research for potential therapies. ..