Eomes

Summary

Gene Symbol: Eomes
Description: eomesodermin
Alias: C77258, TBR-2, Tbr2, eomesodermin homolog, T-box brain protein 2, T-brain-2
Species: mouse

Top Publications

  1. pmc Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex
    Alessandro Sessa
    Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Neuron 60:56-69. 2008
  2. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
  3. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
  4. pmc Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Dev Dyn 238:2800-12. 2009
  5. pmc RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    J Cell Sci 123:586-94. 2010
  6. doi Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon
    Daichi Kawaguchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:3849-58. 2008
  7. ncbi A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain
    N Kimura
    Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Brain Res Dev Brain Res 115:183-93. 1999
  8. ncbi Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells
    P Shier
    The RW Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    Immunogenetics 51:771-8. 2000
  9. ncbi Tbr1 regulates differentiation of the preplate and layer 6
    R F Hevner
    Nina Ireland Laboratory of, Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 29:353-66. 2001
  10. ncbi Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development
    A Bulfone
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    Mech Dev 84:133-8. 1999

Research Grants

  1. Development of Sensory maps in the Mammalian neocortex
    Yasushi Nakagawa; Fiscal Year: 2010
  2. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
  3. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
  4. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. pmc Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex
    Alessandro Sessa
    Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Neuron 60:56-69. 2008
    T-brain gene-2 (Tbr2) is specifically expressed in the intermediate (basal) progenitor cells (IPCs) of the developing cerebral cortex; however, its function in this biological context has so far been overlooked due to the early lethality ..
  2. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
    ..we show that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6...
  3. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
    ..Thus our results also indicate novel roles for the CSF-1R in the regulation of corticogenesis...
  4. pmc Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Dev Dyn 238:2800-12. 2009
    ..Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development...
  5. pmc RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    J Cell Sci 123:586-94. 2010
    ..Our results demonstrate important functions for Dicer in regulating NSC development by maintaining proper signaling pathways related to cell survival and differentiation...
  6. doi Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon
    Daichi Kawaguchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:3849-58. 2008
    ....
  7. ncbi A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain
    N Kimura
    Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Brain Res Dev Brain Res 115:183-93. 1999
    We have identified and characterized a new member of the mammalian brain-specific T-box gene family, Tbr2, which is closely related to mouse Tbr1, and to the Xenopus earliest mesodermal gene, Eomesodermin...
  8. ncbi Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells
    P Shier
    The RW Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    Immunogenetics 51:771-8. 2000
    ..In addition, phylogenetic analyses indicate that Tbt-1 co-evolved with adaptive immune responses. Thus, Tbt-1 is the first T-box transcription factor shown to be specific for Th1 cell differentiation...
  9. ncbi Tbr1 regulates differentiation of the preplate and layer 6
    R F Hevner
    Nina Ireland Laboratory of, Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 29:353-66. 2001
    ..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development...
  10. ncbi Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development
    A Bulfone
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    Mech Dev 84:133-8. 1999
    ..Here we report the cloning of chicken Tbr1 and of murine and chicken Tbr2 (orthologs of the Xenopus eomesodermin gene), the mapping of the murine Tbr2 to chromosome 9, and their pattern of ..
  11. ncbi Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
    K Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
    Development 128:193-205. 2001
    ..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system...
  12. pmc MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex
    Jill M Weimer
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 136:2965-75. 2009
    ....
  13. ncbi Expression of the T-box gene Eomesodermin during early mouse development
    B G Ciruna
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada
    Mech Dev 81:199-203. 1999
    ..Although mEomes expression disappears from the embryo at late-streak stages, a second domain of mEomes expression is observed in the telencephalon beginning around E10.5...
  14. ncbi Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin
    S N Hancock
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Mech Dev 81:205-8. 1999
    ..Later, eomesodermin is expressed in the developing forebrain, in a pattern largely overlapping a closely related T-box gene, Tbr1 ([Bulfone et al., 1995]), and is also seen in a localized area of each limb...
  15. ncbi Eomesodermin is required for mouse trophoblast development and mesoderm formation
    A P Russ
    Wellcome CRC Institute for Cancer and Developmental Biology, and Department of Physiology, University of Cambridge, UK
    Nature 404:95-9. 2000
    ..Our results indicate that Eomesodermin defines a conserved molecular pathway controlling the morphogenetic movements of germ layer formation and has acquired a new function in mammals in the differentiation of trophoblast...
  16. ncbi Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium
    Luca Muzio
    Department of Biological and Technological Research DIBIT, Istituto Scientifico H San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Cereb Cortex 12:129-39. 2002
    ....
  17. ncbi Control of effector CD8+ T cell function by the transcription factor Eomesodermin
    Erika L Pearce
    Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 302:1041-3. 2003
    ..We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo...
  18. ncbi Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    Dan Strumpf
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
    Development 132:2093-102. 2005
    ..However, a positive regulator of TE cell fate has not been described. The T-box protein eomesodermin (Eomes) and the caudal-type homeodomain protein Cdx2 are expressed in the TE, and both Eomes and Cdx2 homozygous mutant ..
  19. ncbi Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning
    Martyn Donnison
    AgResearch Crown Research Institute, Ruakura Campus, East Street, Hamilton 2001, New Zealand
    Development 132:2299-308. 2005
    ..Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development...
  20. ncbi Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium
    Luca Muzio
    Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 25:4435-41. 2005
    ..Remarkably, in the absence of Foxg1, additional inactivation of the medial fates promoter Emx2, although not suppressing cortical specification, conversely rescues overproduction of Reelin(on) neurons...
  21. pmc Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells
    S Yamamoto
    Division of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 102:15983-8. 2005
    ..However, mutant NSPCs were able to self-renew, demonstrating that Shp2-binding sites on FRS2alpha play an important role in NSPC proliferation but are dispensable for NSPC self-renewing capacity after FGF2 stimulation...
  22. ncbi Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation
    Hitoshi Niwa
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minamimachi, Kobe, Hyogo 650 0047, Japan
    Cell 123:917-29. 2005
    ..This suggests that reciprocal inhibition between lineage-specific transcription factors might be involved in the first differentiation event of mammalian development...
  23. ncbi Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampus
    Robert F Hevner
    Department of Pathology, University of Washington, Harborview Medical Center, Harborview Pathology, Box 359791, 325 Ninth Ave, Seattle, WA 98104, USA
    Neurosci Res 55:223-33. 2006
    ..Our work has focused on Pax6, Tbr2/Eomes, NeuroD, and Tbr1, which are expressed sequentially during the neurogenesis of pyramidal-projection neurons...
  24. pmc Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism
    Jane C Quinn
    Genes and Development Group, Department of Biomedical Sciences, Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK
    Dev Biol 302:50-65. 2007
    ..in apical progenitors and is downregulated in basal progenitors, which upregulate the transcription factor Tbr2. Here we show that Pax6(-/-) cells are under-represented in the cortex of Pax6(+/+)<-->Pax6(-/-) chimeras ..
  25. ncbi Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
    Pontus C Holm
    Institute for Stem Cell Research, National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 34:99-119. 2007
    ..levels of various transcription factors involved in neurogenesis (like Satb2, Nfia, AP-2gamma, NeuroD6, Ngn2, Tbr2, Bhlhb5) and the retinoic acid signalling molecule Rlbp1 were reduced...
  26. pmc Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors
    Carolyn N Wrobel
    Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 E Chicago Ave, Ward 3 190, Chicago, IL 60611, USA
    Dev Biol 309:285-97. 2007
    ..beta-catenin activity expands RC2 and Pax6 expression in the developing cortex while postponing the onset of Tbr2 expression, suggesting a delay in maturation of radial glia into intermediate progenitors...
  27. ncbi A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus
    Ondrej Machon
    Section for Cellular and Genetic Therapy, Institute of Microbiology, Center of Molecular Biology and Neuroscience, The National Hospital, N 1349 Oslo, Norway
    Dev Biol 311:223-37. 2007
    ..Wnt signaling in the developing cortex and delays the expression onset of the neurogenic factors Pax6, Ngn2 and Tbr2 and subsequent neurogenesis...
  28. ncbi Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone
    Beatriz Cubelos
    Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus de Cantoblanco, Madrid 28049, Spain
    Cereb Cortex 18:1758-70. 2008
    ..Our results point to Cux-2 as a key element in the control of the proliferation rates of the SVZ precursors and the number of upper cortical neurons, without altering the number of deep cortical layers...
  29. pmc Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression
    Julie A Siegenthaler
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Cereb Cortex 18:1865-75. 2008
    ..Interestingly, cell proliferation in the SZ and intermediate progenitor cell (IPC) production (noted by Tbr2-immunostaining) was reduced in Foxg1(+/Cre) brains...
  30. ncbi Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo
    Amy Ralston
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, MARS Building, Toronto Medical Discovery Tower, 101 College St, Toronto, ON, Canada
    Dev Biol 313:614-29. 2008
    ..Cdx2 therefore appears to act downstream of the first lineage decision, suggesting that processes influencing lineage allocation or morphogenesis may regulate Cdx2 expression along the inside/outside axis of the embryo...
  31. ncbi Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos
    Noriyuki Nishioka
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe, Hyogo 650 0047, Japan
    Mech Dev 125:270-83. 2008
    ..None of the TE specific genes, including Eomes and a Cdx2 independent gene, Fgfr2, was detected in Tead4-/- embryos...
  32. ncbi Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis
    Daijiro Konno
    Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, and CREST, Japan Science and Technology Corporation, RIKEN, 2 2 3 Minatojima minamimachi, Chuou ku, Kobe 650 0047, Japan
    Nat Cell Biol 10:93-101. 2008
    ..Our results suggest that planar mitosis ensures the self-renewal of neuroepithelial progenitors by one daughter inheriting both apical and basal compartments during neurogenesis...
  33. doi Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 135:501-11. 2008
    The T-box transcription factor eomesodermin (Eomes) has been implicated as an important component in germ layer induction and patterning in vertebrate embryos...
  34. doi Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesis
    Anne Duggan
    Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Comp Neurol 507:1497-520. 2008
    ..We propose that, in mice and humans, INSM1 is likewise expressed transiently during terminal neurogenic divisions, from late progenitors to nascent neurons, and particularly during symmetric neuronogenic divisions...
  35. pmc Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination
    Ashley S Pawlisz
    Department of Neurology and Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, 303 E Superior Street, Chicago, IL 60611, USA
    Hum Mol Genet 17:2441-55. 2008
    ..Our data suggest that maintaining the shape and cell-cell interactions of radial glial neuroepithelial progenitors by the Lis1-Nde1 complex is essential for their self renewal during the early phase of corticogenesis...
  36. doi Hedgehog signaling is involved in development of the neocortex
    Munekazu Komada
    Departmant of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Development 135:2717-27. 2008
    ..Reduced Shh immunoreactivity in mutant dorsal telencephalons supports the above phenotypes. Our data indicate that Shh signaling plays an important role in development of the neocortex...
  37. pmc Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
    ..We show that CD8+ T cells deficient in the transcription factors T-bet and eomesodermin (Eomes) fail to differentiate into functional killers required for defense against lymphocytic choriomeningitis virus...
  38. doi Neurogenin 2 controls cortical neuron migration through regulation of Rnd2
    Julian Ik Tsen Heng
    Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nature 455:114-8. 2008
    ..Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP-binding protein...
  39. doi Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex
    Lilla M Farkas
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Neuron 60:40-55. 2008
    ..the basal (rather than apical) side of the ventricular zone and induced expression of the basal progenitor marker Tbr2. Remarkably, these cells remained negative for Tis21, a marker of neurogenic progenitors, and did not generate ..
  40. pmc miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
    Davide De Pietri Tonelli
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 135:3911-21. 2008
    ..5. Our results support the emerging concept that progenitors are less dependent on miRNAs than their differentiated progeny, and raise interesting perspectives as to the expansion of somatic stem cells...
  41. doi Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells
    Wataru Ochiai
    Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Mol Cell Neurosci 40:225-33. 2009
    ..the neocortical ventricular zone, we examined at high resolution the spatiotemporal expression patterns of Ngn2 and Tbr2. Individually DiI-labeled daughter cells were tracked from their birth in slice cultures and immunostained for Ngn2 ..
  42. pmc Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling
    Guangnan Li
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94158, USA
    Development 136:327-35. 2009
    ..These results demonstrate that the relocation of neural precursors in the dentate gyrus consists of discrete steps regulated by multiple pathways...
  43. doi The tumor suppressor Pml regulates cell fate in the developing neocortex
    Tarik Regad
    Medicial Research Council Toxicology Unit, University of Leicester, Box 138 Lancaster Road, Leicester LE1 7JL, UK
    Nat Neurosci 12:132-40. 2009
    ..Together, these findings reveal an unexpected role of Pml in controlling the function of NPCs in the CNS...
  44. pmc Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse
    Sharon W Way
    Division of Medical Genetics, Department of Pediatrics, University of Texas Health Science Center, Houston, TX 77030, USA
    Hum Mol Genet 18:1252-65. 2009
    ..Developmental analysis demonstrated that loss of Tsc2 increased the subventricular Tbr2-positive basal cell progenitor pool at the expense of early born Tbr1-positive post-mitotic neurons...
  45. pmc Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex
    Tom Kowalczyk
    Departments of Neurological Surgery and Pathology, University of Washington and Center for Neuroscience, Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
    Cereb Cortex 19:2439-50. 2009
    ..We found that basal mitoses expressing transcription factor Tbr2 (an INP marker) were present throughout corticogenesis, from embryonic day 10.5 through birth...
  46. doi Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors
    Jeremy N Pulvers
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 136:1859-68. 2009
    ..Our results show that Brca1 is required for the cerebral cortex to develop to normal size by preventing the apoptosis of early cortical progenitors and their immediate progeny...
  47. pmc Regulation of radial glial survival by signals from the meninges
    Randor Radakovits
    The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA
    J Neurosci 29:7694-705. 2009
    ..Our findings demonstrate that attachment of RGC processes at the meninges is important for RGC survival and the control of cortical size...
  48. doi Generation and analysis of a mouse line harboring GFP in the Eomes/Tbr2 locus
    Sebastian J Arnold
    Renal Division, University Hospital Freiburg, Freiburg, Germany
    Genesis 47:775-81. 2009
    During mouse embryonic development, the T-box transcription factor Eomes/Tbr2 is expressed in highly dynamic patterns in various progenitor cell types...
  49. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
    ..Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis...
  50. doi Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2
    Amy Ralston
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, MARS Building, Toronto Medical Discovery Tower, Toronto, ON M5G 1L7, Canada
    Development 137:395-403. 2010
    ....
  51. doi Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex
    Atsushi Kuwahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 137:1035-44. 2010
    ..These results reveal that Wnt signaling via N-myc is crucial for the control of neuron number in the developing neocortex...
  52. pmc The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma
    Ryoji Yagi
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:507-17. 2010
    ..Another T-box-containing transcription factor Eomes, but not T-bet, was induced both in GATA3-deficient CD4(+) T cells differentiated under Th2 cell conditions and in ..
  53. pmc Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors
    Sofia B Lizarraga
    Division of Genetics and the Manton Center for Orphan Disease Research, Children s Hospital Boston, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Development 137:1907-17. 2010
    ..Our findings suggest that the reduction in brain size observed in humans with mutations in CDK5RAP2 is associated with impaired centrosomal function and with changes in mitotic spindle orientation during progenitor proliferation...
  54. doi T-bet and eomesodermin are required for T cell-mediated antitumor immune responses
    Yibei Zhu
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 185:3174-83. 2010
    ..T-bet and Eomesodermin (Eomes) have been suggested to be master regulators of Th1 cells and CD8(+) T cells...
  55. pmc Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations
    Kaya Bilguvar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 467:207-10. 2010
    ..These findings unify previously disparate aspects of cerebral cortical development and highlight the use of whole-exome sequencing to identify disease loci in settings in which traditional methods have proved challenging...
  56. pmc Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche
    Arnob Banerjee
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 185:4988-92. 2010
    ..T-bet and eomesodermin (Eomes) are key transcription factors of cytotoxic lymphocyte lineages...
  57. pmc Pluripotency factors regulate definitive endoderm specification through eomesodermin
    Adrian Kee Keong Teo
    Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK
    Genes Dev 25:238-50. 2011
    ..Indeed, these transcription factors control the expression of EOMESODERMIN (EOMES), which marks the onset of endoderm specification...
  58. doi SOX2 expression levels distinguish between neural progenitor populations of the developing dorsal telencephalon
    Scott R Hutton
    Department of Genetics, University of North Carolina, 115 Mason Farm Rd, CB 7250, Chapel Hill, NC 27599, USA
    Dev Biol 352:40-7. 2011
    ....
  59. doi Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin
    Kenji Ichiyama
    Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Immunity 34:741-54. 2011
    ..pathway by using Smad2 and Smad3 double-deficient T cells and identified the transcription factor Eomesodermin (Eomes), whose expression was suppressed by TGF-β via the c-Jun N-terminal kinase (JNK)-c-Jun signaling pathway...
  60. pmc FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons
    Satoru Yamagishi
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz, Martinsried, Germany
    EMBO J 30:2920-33. 2011
    ..Hence, the shed FLRT2 and FLRT3 ECDs represent a novel family of chemorepellents for Unc5-positive neurons and FLRT2/Unc5D signalling modulates cortical neuron migration...
  61. pmc CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation
    Harry Z Qui
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 187:3555-64. 2011
    ..This mechanism might be therapeutically useful because CD134 plus CD137 dual costimulation induced CD4 T cell-dependent tumoricidal function in a mouse melanoma model...
  62. pmc Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex
    Maria Pia Postiglione
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Neuron 72:269-84. 2011
    ..Our results indicate that the orientation of progenitor cell divisions is important for correct lineage specification in the developing mammalian brain...
  63. doi Reelin sets the pace of neocortical neurogenesis
    Jarmila Lakomá
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Campus de San Juan s n, E 03550 San Juan de Alicante, Spain
    Development 138:5223-34. 2011
    ..These results indicate that reelin and Notch signaling cooperate to set the pace of neocortical neurogenesis, a prerequisite for proper neuronal migration and cortical layering...
  64. pmc The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation
    Scott M Gordon
    Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
    Immunity 36:55-67. 2012
    ..We show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop NK cells...
  65. pmc Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons
    Rebecca D Hodge
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98101, USA
    J Neurosci 32:6275-87. 2012
    ..Here we show that Tbr2 (also known as Eomes), a T-box transcription factor expressed by intermediate neuronal progenitors (INPs), is critically required for ..
  66. pmc A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis
    Ruth Simon
    Institute of Molecular and Cellular Anatomy, Ulm University, Ulm, Germany
    EMBO J 31:2922-36. 2012
    ..Together, our data define an important novel regulatory pathway in hippocampal development, by linking transcriptional functions of Bcl11b to Desmoplakin, a molecule known to act on cell adhesion...
  67. pmc Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate
    Goichi Miyoshi
    NYU Neuroscience Institute, Department of Physiology and Neuroscience, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Neuron 74:1045-58. 2012
    ..Thus, the dynamic expression of FoxG1 during migration within the intermediate zone is essential for the proper assembly of the cerebral cortex...
  68. pmc TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation
    Ribhu Nayar
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 109:E2794-802. 2012
    ..T cells, characterized by their high expression of CD44, CD122, CXCR3, and the transcription factor, Eomesodermin (Eomes). One component of this altered development is a non-CD8(+) T cell-intrinsic role for IL-4...
  69. pmc A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo
    Dang Vinh Do
    Cancer Science Institute of Singapore, Singapore 117599, Singapore
    Genes Dev 27:1378-90. 2013
    ..These results provide a novel genetic model of cell fate determination operating through STAT3 in the preimplantation embryo and pluripotent stem cells in vivo. ..
  70. pmc Establishment of totipotency does not depend on Oct4A
    Guangming Wu
    Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Röntgenstrasse 20, 48149 Munster, Germany
    Nat Cell Biol 15:1089-97. 2013
    ....
  71. pmc GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst
    Nadine Schrode
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Dev Cell 29:454-67. 2014
    ..This study provides a framework for quantitative analyses of mammalian embryos and establishes GATA6 as a nodal point in the gene regulatory network driving ICM lineage specification. ..
  72. pmc COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling
    Andrea Faedo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Cereb Cortex 18:2117-31. 2008
    ..We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling...
  73. doi Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output
    Rebecca D Hodge
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98101 1304, USA
    J Neurosci 28:3707-17. 2008
    ..To study the role of transcription factors (TFs), we focused on Tbr2 (T-box brain gene 2), which has been implicated previously in developmental glutamatergic neurogenesis...
  74. doi COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression
    Christian Alfano
    Telethon Institute of Genetics and Medicine TIGEM, Developmental Disorders Program, 80131 Naples, Italy
    Development 138:4685-97. 2011
    ..Thus, our data demonstrate that COUP-TFI modulates late-born neuron migration and favours proper differentiation of CPNs by finely regulating Rnd2 expression levels...
  75. pmc Ikaros promotes early-born neuronal fates in the cerebral cortex
    Jessica M Alsiö
    Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Proc Natl Acad Sci U S A 110:E716-25. 2013
    ..These data suggest that Ikaros plays a similar role in regulating early temporal fates in the mammalian cerebral cortex as Ikaros/Hunchback proteins do in the Drosophila nerve cord...
  76. pmc IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells
    Qianting Yang
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Immunol 41:3351-60. 2011
    ..The synergistic effect of IL-33 and IL-12 is partly mediated by Gadd45b. Together, these in vitro data establish a novel role of IL-33 in promoting effector type 1 adaptive immune responses...
  77. pmc Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex
    Keisuke Watanabe
    Department of Morphological Neural Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Development 138:4979-90. 2011
    ..These results indicate that Dpy19l1 is required for the proper radial migration of glutamatergic neurons, and suggest an evolutionarily conserved role for the Dpy19 family in neuronal migration...
  78. pmc Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6
    Lynn Wang
    Department of Neuroscience, Developmental Biology Center and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Neural Dev 6:35. 2011
    ..These 'basal' progenitor cells form the subventricular zone and are responsible for generating the majority of neocortical neurons. However, not much has been studied on similar types of progenitor cells in other brain regions...
  79. doi α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2
    Jacque P K Ip
    Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Nat Neurosci 15:39-47. 2011
    ..These findings establish a new α2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders...
  80. pmc Sin3a is essential for the genome integrity and viability of pluripotent cells
    Patrick McDonel
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Dev Biol 363:62-73. 2012
    ..These results indicate that Sin3a protects the genomic integrity of pluripotent embryonic cells and governs their unusual cell cycle...
  81. pmc Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Dis Model Mech 5:351-65. 2012
    ..These findings present novel insights into the function of Sall1 in the developing mouse cortex and provide avenues for future research into potential neural deficits in individuals with TBS...
  82. pmc Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain
    Darren J Yip
    Regenerative Medicine Program, Ottawa Hospital Research Institute, and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada
    Dev Cell 22:871-8. 2012
    ..We demonstrate that Snf2l binds to the Foxg1 locus at midneurogenesis and that the phenotype is rescued by reducing Foxg1 dosage, thus revealing that Snf2l and Foxg1 function antagonistically to regulate brain size...
  83. pmc Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation
    Gewei Lian
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Neurosci 32:7672-84. 2012
    ..Collectively, our results demonstrate a molecular mechanism whereby FlnA loss impaired G2 to M phase entry, leading to cell cycle prolongation, compromised neural progenitor proliferation, and reduced brain size...
  84. pmc MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain
    Tomasz Jan Nowakowski
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    Proc Natl Acad Sci U S A 110:7056-61. 2013
    ..The generation of intermediate progenitors is regulated by the transcription factor Tbr2, whose expression marks these cells. We investigated how this mechanism might be controlled...
  85. pmc Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling
    Branden R Nelson
    Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, Washington 98101, USA or
    J Neurosci 33:9122-39. 2013
    ..Thus, the embryonic progenitor niche includes a network of dynamic cell-cell interactions, using different combinations of Notch signaling molecules to maintain and likely diversify progenitor pools...
  86. ncbi Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation
    K D Tremblay
    Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 128:3609-21. 2001
    ..Collectively, these data have uncovered a unique function for Smad1 signaling in coordinating the growth of extra-embryonic structures necessary to support development within the uterine environment...
  87. ncbi Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis
    Andrea Faedo
    Stem Cell Research Institute SCRI, Istituto Scientifico HS Raffaele, Via Olgettina, 58 Milan, Italy
    Mech Dev 116:157-60. 2002
    ..The sequence and expression of Tbr1 and eomesodermin/Tbr2 are closely related to T-bet/Tbx21...
  88. pmc An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
    Marc K Saba-El-Leil
    Institut de Recherches Cliniques de Montréal and Department of Pharmacology, Universite de Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    EMBO Rep 4:964-8. 2003
    ..The inability of Erk1 to compensate for Erk2 function suggests a specific function for Erk2 in normal trophoblast development in the mouse, probably in regulating the proliferation of polar trophectoderm cells...
  89. pmc In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis
    Josée Aubin
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 18:1482-94. 2004
    ..In addition, formation of PGCs is impaired in Smad1(L/L) mutants, but restored by allelic complementation in Smad1(C/L) compound mutants. These results underscore the need to tightly balance BMP and MAPK signaling pathways through Smad1...
  90. ncbi Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning
    Cindy C Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 273:149-59. 2004
    ....
  91. pmc The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development
    N Gotoh
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Cell Biol 25:4105-16. 2005
    ..These experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis...
  92. ncbi Eomesodermin is expressed in mouse oocytes and pre-implantation embryos
    Josie McConnell
    Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Mol Reprod Dev 71:399-404. 2005
    ..Our results are consistent with mEomesodermin having a role in early preimplantation development and inner cell mass formation in addition to its function in the trophoblast lineage...
  93. ncbi IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression
    Akira Suto
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 177:3721-7. 2006
    ..Recently, it has been reported that Eomesodermin (Eomes), a member of the T-box gene family, is expressed in developing CD8+ T cells and plays an important role in ..
  94. ncbi Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:9184-95. 2006
    ..We studied the development of UBCs, using transcription factor Tbr2/Eomes as a marker for UBCs and their progenitors in embryonic and postnatal mouse cerebellum...
  95. pmc Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
    ..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
  96. pmc Eomes::GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo
    Gloria S Kwon
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genesis 45:208-17. 2007
    ..We describe the spatiotemporal expression of GFP in embryos of a Tg(Eomes::GFP) BAC transgenic strain, and have compared it with the localization of endogenous Eomes transcripts and ..
  97. ncbi BMP signalling inhibits premature neural differentiation in the mouse embryo
    Aida Di-Gregorio
    Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Development 134:3359-69. 2007
    ..Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo...
  98. ncbi Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis
    Jeffery R Barrow
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 312:312-20. 2007
    ....
  99. doi Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool
    Nina Solberg
    Section for Cellular and Genetic Therapy, Institute of Microbiology, Rikshospitalet, Oslo, Norway
    Dev Dyn 237:1799-811. 2008
    ..The lower number of progenitors in the dentate gyrus was not rescued after migration to the subgranular zone and thus the dentate gyrus lacked the entire internal blade and a part of the external blade from postnatal to adult stages...
  100. pmc E2F4 cooperates with pRB in the development of extra-embryonic tissues
    Eunice Y Lee
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Biol 332:104-15. 2009
    ..Taken together, our data show that pRB and E2F4 cooperate in placental development, but play largely non-overlapping roles in the development of many embryonic tissues...
  101. pmc The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain
    Xudong Zhao
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 17:210-21. 2009
    ..Our results indicate that Huwe1 balances proliferation and neurogenesis in the developing brain and that this pathway is subverted in malignant brain tumors...

Research Grants4

  1. Development of Sensory maps in the Mammalian neocortex
    Yasushi Nakagawa; Fiscal Year: 2010
    ..abstract_text> ..
  2. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
    ..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
  3. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  4. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007
    ..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..