Genomes and Genes
Gene Symbol: Eomes
Alias: C77258, TBR-2, Tbr2, eomesodermin homolog, T-box brain protein 2, T-brain-2
Publications148 found, 100 shown here
- Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortexAlessandro Sessa
Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Neuron 60:56-69. 2008T-brain gene-2 (Tbr2) is specifically expressed in the intermediate (basal) progenitor cells (IPCs) of the developing cerebral cortex; however, its function in this biological context has so far been overlooked due to the early lethality ..
- Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortexChris Englund
Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
J Neurosci 25:247-51. 2005..we show that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6...
- The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturationSayan Nandi
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
Dev Biol 367:100-13. 2012..Thus our results also indicate novel roles for the CSF-1R in the regulation of corticogenesis...
- Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous systemYoko Kawase-Koga
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
Dev Dyn 238:2800-12. 2009..Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development...
- RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cellsYoko Kawase-Koga
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
J Cell Sci 123:586-94. 2010..Our results demonstrate important functions for Dicer in regulating NSC development by maintaining proper signaling pathways related to cell survival and differentiation...
- Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalonDaichi Kawaguchi
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Development 135:3849-58. 2008....
- A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brainN Kimura
Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Brain Res Dev Brain Res 115:183-93. 1999We have identified and characterized a new member of the mammalian brain-specific T-box gene family, Tbr2, which is closely related to mouse Tbr1, and to the Xenopus earliest mesodermal gene, Eomesodermin...
- Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cellsP Shier
The RW Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
Immunogenetics 51:771-8. 2000..In addition, phylogenetic analyses indicate that Tbt-1 co-evolved with adaptive immune responses. Thus, Tbt-1 is the first T-box transcription factor shown to be specific for Th1 cell differentiation...
- Tbr1 regulates differentiation of the preplate and layer 6R F Hevner
Nina Ireland Laboratory of, Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 29:353-66. 2001..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development...
- Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain developmentA Bulfone
Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
Mech Dev 84:133-8. 1999..Here we report the cloning of chicken Tbr1 and of murine and chicken Tbr2 (orthologs of the Xenopus eomesodermin gene), the mapping of the murine Tbr2 to chromosome 9, and their pattern of ..
- Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalonK Yun
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
Development 128:193-205. 2001..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system...
- MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortexJill M Weimer
UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Development 136:2965-75. 2009....
- Expression of the T-box gene Eomesodermin during early mouse developmentB G Ciruna
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada
Mech Dev 81:199-203. 1999..Although mEomes expression disappears from the embryo at late-streak stages, a second domain of mEomes expression is observed in the telencephalon beginning around E10.5...
- Mapping and expression analysis of the mouse ortholog of Xenopus EomesoderminS N Hancock
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
Mech Dev 81:205-8. 1999..Later, eomesodermin is expressed in the developing forebrain, in a pattern largely overlapping a closely related T-box gene, Tbr1 ([Bulfone et al., 1995]), and is also seen in a localized area of each limb...
- Eomesodermin is required for mouse trophoblast development and mesoderm formationA P Russ
Wellcome CRC Institute for Cancer and Developmental Biology, and Department of Physiology, University of Cambridge, UK
Nature 404:95-9. 2000..Our results indicate that Eomesodermin defines a conserved molecular pathway controlling the morphogenetic movements of germ layer formation and has acquired a new function in mammals in the differentiation of trophoblast...
- Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordiumLuca Muzio
Department of Biological and Technological Research DIBIT, Istituto Scientifico H San Raffaele, Via Olgettina 58, 20132 Milano, Italy
Cereb Cortex 12:129-39. 2002....
- Control of effector CD8+ T cell function by the transcription factor EomesoderminErika L Pearce
Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 302:1041-3. 2003..We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo...
- Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocystDan Strumpf
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
Development 132:2093-102. 2005..However, a positive regulator of TE cell fate has not been described. The T-box protein eomesodermin (Eomes) and the caudal-type homeodomain protein Cdx2 are expressed in the TE, and both Eomes and Cdx2 homozygous mutant ..
- Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterningMartyn Donnison
AgResearch Crown Research Institute, Ruakura Campus, East Street, Hamilton 2001, New Zealand
Development 132:2299-308. 2005..Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development...
- Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial palliumLuca Muzio
Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy
J Neurosci 25:4435-41. 2005..Remarkably, in the absence of Foxg1, additional inactivation of the medial fates promoter Emx2, although not suppressing cortical specification, conversely rescues overproduction of Reelin(on) neurons...
- Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cellsS Yamamoto
Division of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
Proc Natl Acad Sci U S A 102:15983-8. 2005..However, mutant NSPCs were able to self-renew, demonstrating that Shp2-binding sites on FRS2alpha play an important role in NSPC proliferation but are dispensable for NSPC self-renewing capacity after FGF2 stimulation...
- Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiationHitoshi Niwa
Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minamimachi, Kobe, Hyogo 650 0047, Japan
Cell 123:917-29. 2005..This suggests that reciprocal inhibition between lineage-specific transcription factors might be involved in the first differentiation event of mammalian development...
- Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampusRobert F Hevner
Department of Pathology, University of Washington, Harborview Medical Center, Harborview Pathology, Box 359791, 325 Ninth Ave, Seattle, WA 98104, USA
Neurosci Res 55:223-33. 2006..Our work has focused on Pax6, Tbr2/Eomes, NeuroD, and Tbr1, which are expressed sequentially during the neurogenesis of pyramidal-projection neurons...
- Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanismJane C Quinn
Genes and Development Group, Department of Biomedical Sciences, Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK
Dev Biol 302:50-65. 2007..in apical progenitors and is downregulated in basal progenitors, which upregulate the transcription factor Tbr2. Here we show that Pax6(-/-) cells are under-represented in the cortex of Pax6(+/+)<-->Pax6(-/-) chimeras ..
- Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalonPontus C Holm
Institute for Stem Cell Research, National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
Mol Cell Neurosci 34:99-119. 2007..levels of various transcription factors involved in neurogenesis (like Satb2, Nfia, AP-2gamma, NeuroD6, Ngn2, Tbr2, Bhlhb5) and the retinoic acid signalling molecule Rlbp1 were reduced...
- Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitorsCarolyn N Wrobel
Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 E Chicago Ave, Ward 3 190, Chicago, IL 60611, USA
Dev Biol 309:285-97. 2007..beta-catenin activity expands RC2 and Pax6 expression in the developing cortex while postponing the onset of Tbr2 expression, suggesting a delay in maturation of radial glia into intermediate progenitors...
- A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampusOndrej Machon
Section for Cellular and Genetic Therapy, Institute of Microbiology, Center of Molecular Biology and Neuroscience, The National Hospital, N 1349 Oslo, Norway
Dev Biol 311:223-37. 2007..Wnt signaling in the developing cortex and delays the expression onset of the neurogenic factors Pax6, Ngn2 and Tbr2 and subsequent neurogenesis...
- Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zoneBeatriz Cubelos
Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus de Cantoblanco, Madrid 28049, Spain
Cereb Cortex 18:1758-70. 2008..Our results point to Cux-2 as a key element in the control of the proliferation rates of the SVZ precursors and the number of upper cortical neurons, without altering the number of deep cortical layers...
- Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expressionJulie A Siegenthaler
Department of Neuroscience and Physiology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Cereb Cortex 18:1865-75. 2008..Interestingly, cell proliferation in the SZ and intermediate progenitor cell (IPC) production (noted by Tbr2-immunostaining) was reduced in Foxg1(+/Cre) brains...
- Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryoAmy Ralston
Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, MARS Building, Toronto Medical Discovery Tower, 101 College St, Toronto, ON, Canada
Dev Biol 313:614-29. 2008..Cdx2 therefore appears to act downstream of the first lineage decision, suggesting that processes influencing lineage allocation or morphogenesis may regulate Cdx2 expression along the inside/outside axis of the embryo...
- Tead4 is required for specification of trophectoderm in pre-implantation mouse embryosNoriyuki Nishioka
Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe, Hyogo 650 0047, Japan
Mech Dev 125:270-83. 2008..None of the TE specific genes, including Eomes and a Cdx2 independent gene, Fgfr2, was detected in Tead4-/- embryos...
- Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesisDaijiro Konno
Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, and CREST, Japan Science and Technology Corporation, RIKEN, 2 2 3 Minatojima minamimachi, Chuou ku, Kobe 650 0047, Japan
Nat Cell Biol 10:93-101. 2008..Our results suggest that planar mitosis ensures the self-renewal of neuroepithelial progenitors by one daughter inheriting both apical and basal compartments during neurogenesis...
- Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouseSebastian J Arnold
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Development 135:501-11. 2008The T-box transcription factor eomesodermin (Eomes) has been implicated as an important component in germ layer induction and patterning in vertebrate embryos...
- Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesisAnne Duggan
Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Comp Neurol 507:1497-520. 2008..We propose that, in mice and humans, INSM1 is likewise expressed transiently during terminal neurogenic divisions, from late progenitors to nascent neurons, and particularly during symmetric neuronogenic divisions...
- Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and laminationAshley S Pawlisz
Department of Neurology and Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, 303 E Superior Street, Chicago, IL 60611, USA
Hum Mol Genet 17:2441-55. 2008..Our data suggest that maintaining the shape and cell-cell interactions of radial glial neuroepithelial progenitors by the Lis1-Nde1 complex is essential for their self renewal during the early phase of corticogenesis...
- Hedgehog signaling is involved in development of the neocortexMunekazu Komada
Departmant of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
Development 135:2717-27. 2008..Reduced Shh immunoreactivity in mutant dorsal telencephalons supports the above phenotypes. Our data indicate that Shh signaling plays an important role in development of the neocortex...
- Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesoderminAndrew M Intlekofer
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 321:408-11. 2008..We show that CD8+ T cells deficient in the transcription factors T-bet and eomesodermin (Eomes) fail to differentiate into functional killers required for defense against lymphocytic choriomeningitis virus...
- Neurogenin 2 controls cortical neuron migration through regulation of Rnd2Julian Ik Tsen Heng
Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Nature 455:114-8. 2008..Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP-binding protein...
- Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortexLilla M Farkas
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Neuron 60:40-55. 2008..the basal (rather than apical) side of the ventricular zone and induced expression of the basal progenitor marker Tbr2. Remarkably, these cells remained negative for Tis21, a marker of neurogenic progenitors, and did not generate ..
- miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortexDavide De Pietri Tonelli
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Development 135:3911-21. 2008..5. Our results support the emerging concept that progenitors are less dependent on miRNAs than their differentiated progeny, and raise interesting perspectives as to the expansion of somatic stem cells...
- Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cellsWataru Ochiai
Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
Mol Cell Neurosci 40:225-33. 2009..the neocortical ventricular zone, we examined at high resolution the spatiotemporal expression patterns of Ngn2 and Tbr2. Individually DiI-labeled daughter cells were tracked from their birth in slice cultures and immunostained for Ngn2 ..
- Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signalingGuangnan Li
Department of Neurology, UCSF School of Medicine, San Francisco, CA 94158, USA
Development 136:327-35. 2009..These results demonstrate that the relocation of neural precursors in the dentate gyrus consists of discrete steps regulated by multiple pathways...
- The tumor suppressor Pml regulates cell fate in the developing neocortexTarik Regad
Medicial Research Council Toxicology Unit, University of Leicester, Box 138 Lancaster Road, Leicester LE1 7JL, UK
Nat Neurosci 12:132-40. 2009..Together, these findings reveal an unexpected role of Pml in controlling the function of NPCs in the CNS...
- Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouseSharon W Way
Division of Medical Genetics, Department of Pediatrics, University of Texas Health Science Center, Houston, TX 77030, USA
Hum Mol Genet 18:1252-65. 2009..Developmental analysis demonstrated that loss of Tsc2 increased the subventricular Tbr2-positive basal cell progenitor pool at the expense of early born Tbr1-positive post-mitotic neurons...
- Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortexTom Kowalczyk
Departments of Neurological Surgery and Pathology, University of Washington and Center for Neuroscience, Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
Cereb Cortex 19:2439-50. 2009..We found that basal mitoses expressing transcription factor Tbr2 (an INP marker) were present throughout corticogenesis, from embryonic day 10.5 through birth...
- Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitorsJeremy N Pulvers
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Development 136:1859-68. 2009..Our results show that Brca1 is required for the cerebral cortex to develop to normal size by preventing the apoptosis of early cortical progenitors and their immediate progeny...
- Regulation of radial glial survival by signals from the meningesRandor Radakovits
The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA
J Neurosci 29:7694-705. 2009..Our findings demonstrate that attachment of RGC processes at the meninges is important for RGC survival and the control of cortical size...
- Generation and analysis of a mouse line harboring GFP in the Eomes/Tbr2 locusSebastian J Arnold
Renal Division, University Hospital Freiburg, Freiburg, Germany
Genesis 47:775-81. 2009During mouse embryonic development, the T-box transcription factor Eomes/Tbr2 is expressed in highly dynamic patterns in various progenitor cell types...
- Retinoic acid from the meninges regulates cortical neuron generationJulie A Siegenthaler
Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
Cell 139:597-609. 2009..Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis...
- Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2Amy Ralston
Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, MARS Building, Toronto Medical Discovery Tower, Toronto, ON M5G 1L7, Canada
Development 137:395-403. 2010....
- Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortexAtsushi Kuwahara
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Development 137:1035-44. 2010..These results reveal that Wnt signaling via N-myc is crucial for the control of neuron number in the developing neocortex...
- The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gammaRyoji Yagi
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 32:507-17. 2010..Another T-box-containing transcription factor Eomes, but not T-bet, was induced both in GATA3-deficient CD4(+) T cells differentiated under Th2 cell conditions and in ..
- Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitorsSofia B Lizarraga
Division of Genetics and the Manton Center for Orphan Disease Research, Children s Hospital Boston, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Development 137:1907-17. 2010..Our findings suggest that the reduction in brain size observed in humans with mutations in CDK5RAP2 is associated with impaired centrosomal function and with changes in mitotic spindle orientation during progenitor proliferation...
- T-bet and eomesodermin are required for T cell-mediated antitumor immune responsesYibei Zhu
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Immunol 185:3174-83. 2010..T-bet and Eomesodermin (Eomes) have been suggested to be master regulators of Th1 cells and CD8(+) T cells...
- Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformationsKaya Bilguvar
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nature 467:207-10. 2010..These findings unify previously disparate aspects of cerebral cortical development and highlight the use of whole-exome sequencing to identify disease loci in settings in which traditional methods have proved challenging...
- Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell nicheArnob Banerjee
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 185:4988-92. 2010..T-bet and eomesodermin (Eomes) are key transcription factors of cytotoxic lymphocyte lineages...
- Pluripotency factors regulate definitive endoderm specification through eomesoderminAdrian Kee Keong Teo
Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK
Genes Dev 25:238-50. 2011..Indeed, these transcription factors control the expression of EOMESODERMIN (EOMES), which marks the onset of endoderm specification...
- SOX2 expression levels distinguish between neural progenitor populations of the developing dorsal telencephalonScott R Hutton
Department of Genetics, University of North Carolina, 115 Mason Farm Rd, CB 7250, Chapel Hill, NC 27599, USA
Dev Biol 352:40-7. 2011....
- Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesoderminKenji Ichiyama
Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
Immunity 34:741-54. 2011..pathway by using Smad2 and Smad3 double-deficient T cells and identified the transcription factor Eomesodermin (Eomes), whose expression was suppressed by TGF-β via the c-Jun N-terminal kinase (JNK)-c-Jun signaling pathway...
- FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neuronsSatoru Yamagishi
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz, Martinsried, Germany
EMBO J 30:2920-33. 2011..Hence, the shed FLRT2 and FLRT3 ECDs represent a novel family of chemorepellents for Unc5-positive neurons and FLRT2/Unc5D signalling modulates cortical neuron migration...
- CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiationHarry Z Qui
Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
J Immunol 187:3555-64. 2011..This mechanism might be therapeutically useful because CD134 plus CD137 dual costimulation induced CD4 T cell-dependent tumoricidal function in a mouse melanoma model...
- Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortexMaria Pia Postiglione
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Neuron 72:269-84. 2011..Our results indicate that the orientation of progenitor cell divisions is important for correct lineage specification in the developing mammalian brain...
- Reelin sets the pace of neocortical neurogenesisJarmila Lakomá
Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Campus de San Juan s n, E 03550 San Juan de Alicante, Spain
Development 138:5223-34. 2011..These results indicate that reelin and Notch signaling cooperate to set the pace of neocortical neurogenesis, a prerequisite for proper neuronal migration and cortical layering...
- The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturationScott M Gordon
Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
Immunity 36:55-67. 2012..We show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop NK cells...
- Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neuronsRebecca D Hodge
Department of Neurological Surgery, University of Washington, Seattle, Washington 98101, USA
J Neurosci 32:6275-87. 2012..Here we show that Tbr2 (also known as Eomes), a T-box transcription factor expressed by intermediate neuronal progenitors (INPs), is critically required for ..
- A dual function of Bcl11b/Ctip2 in hippocampal neurogenesisRuth Simon
Institute of Molecular and Cellular Anatomy, Ulm University, Ulm, Germany
EMBO J 31:2922-36. 2012..Together, our data define an important novel regulatory pathway in hippocampal development, by linking transcriptional functions of Bcl11b to Desmoplakin, a molecule known to act on cell adhesion...
- Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plateGoichi Miyoshi
NYU Neuroscience Institute, Department of Physiology and Neuroscience, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
Neuron 74:1045-58. 2012..Thus, the dynamic expression of FoxG1 during migration within the intermediate zone is essential for the proper assembly of the cerebral cortex...
- TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiationRibhu Nayar
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Proc Natl Acad Sci U S A 109:E2794-802. 2012..T cells, characterized by their high expression of CD44, CD122, CXCR3, and the transcription factor, Eomesodermin (Eomes). One component of this altered development is a non-CD8(+) T cell-intrinsic role for IL-4...
- A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivoDang Vinh Do
Cancer Science Institute of Singapore, Singapore 117599, Singapore
Genes Dev 27:1378-90. 2013..These results provide a novel genetic model of cell fate determination operating through STAT3 in the preimplantation embryo and pluripotent stem cells in vivo. ..
- Establishment of totipotency does not depend on Oct4AGuangming Wu
Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Röntgenstrasse 20, 48149 Munster, Germany
Nat Cell Biol 15:1089-97. 2013....
- GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocystNadine Schrode
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Dev Cell 29:454-67. 2014..This study provides a framework for quantitative analyses of mammalian embryos and establishes GATA6 as a nodal point in the gene regulatory network driving ICM lineage specification. ..
- COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signalingAndrea Faedo
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94158, USA
Cereb Cortex 18:2117-31. 2008..We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling...
- Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal outputRebecca D Hodge
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98101 1304, USA
J Neurosci 28:3707-17. 2008..To study the role of transcription factors (TFs), we focused on Tbr2 (T-box brain gene 2), which has been implicated previously in developmental glutamatergic neurogenesis...
- COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expressionChristian Alfano
Telethon Institute of Genetics and Medicine TIGEM, Developmental Disorders Program, 80131 Naples, Italy
Development 138:4685-97. 2011..Thus, our data demonstrate that COUP-TFI modulates late-born neuron migration and favours proper differentiation of CPNs by finely regulating Rnd2 expression levels...
- Ikaros promotes early-born neuronal fates in the cerebral cortexJessica M Alsiö
Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, United Kingdom
Proc Natl Acad Sci U S A 110:E716-25. 2013..These data suggest that Ikaros plays a similar role in regulating early temporal fates in the mammalian cerebral cortex as Ikaros/Hunchback proteins do in the Drosophila nerve cord...
- IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cellsQianting Yang
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Eur J Immunol 41:3351-60. 2011..The synergistic effect of IL-33 and IL-12 is partly mediated by Gadd45b. Together, these in vitro data establish a novel role of IL-33 in promoting effector type 1 adaptive immune responses...
- Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortexKeisuke Watanabe
Department of Morphological Neural Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
Development 138:4979-90. 2011..These results indicate that Dpy19l1 is required for the proper radial migration of glutamatergic neurons, and suggest an evolutionarily conserved role for the Dpy19 family in neuronal migration...
- Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6Lynn Wang
Department of Neuroscience, Developmental Biology Center and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
Neural Dev 6:35. 2011..These 'basal' progenitor cells form the subventricular zone and are responsible for generating the majority of neocortical neurons. However, not much has been studied on similar types of progenitor cells in other brain regions...
- α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2Jacque P K Ip
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Nat Neurosci 15:39-47. 2011..These findings establish a new α2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders...
- Sin3a is essential for the genome integrity and viability of pluripotent cellsPatrick McDonel
Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Dev Biol 363:62-73. 2012..These results indicate that Sin3a protects the genomic integrity of pluripotent embryonic cells and governs their unusual cell cycle...
- Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndromeSusan J Harrison
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Dis Model Mech 5:351-65. 2012..These findings present novel insights into the function of Sall1 in the developing mouse cortex and provide avenues for future research into potential neural deficits in individuals with TBS...
- Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brainDarren J Yip
Regenerative Medicine Program, Ottawa Hospital Research Institute, and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada
Dev Cell 22:871-8. 2012..We demonstrate that Snf2l binds to the Foxg1 locus at midneurogenesis and that the phenotype is rescued by reducing Foxg1 dosage, thus revealing that Snf2l and Foxg1 function antagonistically to regulate brain size...
- Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylationGewei Lian
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
J Neurosci 32:7672-84. 2012..Collectively, our results demonstrate a molecular mechanism whereby FlnA loss impaired G2 to M phase entry, leading to cell cycle prolongation, compromised neural progenitor proliferation, and reduced brain size...
- MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brainTomasz Jan Nowakowski
Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
Proc Natl Acad Sci U S A 110:7056-61. 2013..The generation of intermediate progenitors is regulated by the transcription factor Tbr2, whose expression marks these cells. We investigated how this mechanism might be controlled...
- Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signalingBranden R Nelson
Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, Washington 98101, USA or
J Neurosci 33:9122-39. 2013..Thus, the embryonic progenitor niche includes a network of dynamic cell-cell interactions, using different combinations of Notch signaling molecules to maintain and likely diversify progenitor pools...
- Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formationK D Tremblay
Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 128:3609-21. 2001..Collectively, these data have uncovered a unique function for Smad1 signaling in coordinating the growth of extra-embryonic structures necessary to support development within the uterine environment...
- Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesisAndrea Faedo
Stem Cell Research Institute SCRI, Istituto Scientifico HS Raffaele, Via Olgettina, 58 Milan, Italy
Mech Dev 116:157-60. 2002..The sequence and expression of Tbr1 and eomesodermin/Tbr2 are closely related to T-bet/Tbx21...
- An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast developmentMarc K Saba-El-Leil
Institut de Recherches Cliniques de Montréal and Department of Pharmacology, Universite de Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
EMBO Rep 4:964-8. 2003..The inability of Erk1 to compensate for Erk2 function suggests a specific function for Erk2 in normal trophoblast development in the mouse, probably in regulating the proliferation of polar trophectoderm cells...
- In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasisJosée Aubin
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genes Dev 18:1482-94. 2004..In addition, formation of PGCs is impaired in Smad1(L/L) mutants, but restored by allelic complementation in Smad1(C/L) compound mutants. These results underscore the need to tightly balance BMP and MAPK signaling pathways through Smad1...
- Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterningCindy C Lu
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Dev Biol 273:149-59. 2004....
- The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse developmentN Gotoh
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Mol Cell Biol 25:4105-16. 2005..These experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis...
- Eomesodermin is expressed in mouse oocytes and pre-implantation embryosJosie McConnell
Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
Mol Reprod Dev 71:399-404. 2005..Our results are consistent with mEomesodermin having a role in early preimplantation development and inner cell mass formation in addition to its function in the trophoblast lineage...
- IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expressionAkira Suto
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
J Immunol 177:3721-7. 2006..Recently, it has been reported that Eomesodermin (Eomes), a member of the T-box gene family, is expressed in developing CD8+ T cells and plays an important role in ..
- Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matterChris Englund
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Neurosci 26:9184-95. 2006..We studied the development of UBCs, using transcription factor Tbr2/Eomes as a marker for UBCs and their progenitors in embryonic and postnatal mouse cerebellum...
- Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3Vassiliki Fotaki
Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 26:9282-92. 2006..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
- Eomes::GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryoGloria S Kwon
Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
Genesis 45:208-17. 2007..We describe the spatiotemporal expression of GFP in embryos of a Tg(Eomes::GFP) BAC transgenic strain, and have compared it with the localization of endogenous Eomes transcripts and ..
- BMP signalling inhibits premature neural differentiation in the mouse embryoAida Di-Gregorio
Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
Development 134:3359-69. 2007..Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo...
- Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axisJeffery R Barrow
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Dev Biol 312:312-20. 2007....
- Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor poolNina Solberg
Section for Cellular and Genetic Therapy, Institute of Microbiology, Rikshospitalet, Oslo, Norway
Dev Dyn 237:1799-811. 2008..The lower number of progenitors in the dentate gyrus was not rescued after migration to the subgranular zone and thus the dentate gyrus lacked the entire internal blade and a part of the external blade from postnatal to adult stages...
- E2F4 cooperates with pRB in the development of extra-embryonic tissuesEunice Y Lee
David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Dev Biol 332:104-15. 2009..Taken together, our data show that pRB and E2F4 cooperate in placental development, but play largely non-overlapping roles in the development of many embryonic tissues...
- The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brainXudong Zhao
Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 17:210-21. 2009..Our results indicate that Huwe1 balances proliferation and neurogenesis in the developing brain and that this pathway is subverted in malignant brain tumors...
- Development of Sensory maps in the Mammalian neocortexYasushi Nakagawa; Fiscal Year: 2010..abstract_text> ..
- Zic3 and the Control of Body Pattern FormationSTEPHANIE WARE; Fiscal Year: 2005..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
- Regulation of Laminar Fate in Cerebral CortexRobert Hevner; Fiscal Year: 2006..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
- The role of cell polarity in vertebrate limb outgrowthJeffery Barrow; Fiscal Year: 2007..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..