Genomes and Genes
Gene Symbol: Egfr
Description: epidermal growth factor receptor
Alias: 9030024J15Rik, AI552599, Erbb, Errb1, Errp, Wa5, wa-2, wa2, epidermal growth factor receptor, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, waved 2
Publications165 found, 100 shown here
- Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotypeD W Threadgill
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
Science 269:230-4. 1995Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background...
- Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7Frederic Sierro
Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
Proc Natl Acad Sci U S A 104:14759-64. 2007..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4...
- Strain-dependent epithelial defects in mice lacking the EGF receptorM Sibilia
Institute of Molecular Pathology IMP, Vienna, Austria
Science 269:234-8. 1995Mice and cells lacking the epidermal growth factor receptor (EGFR) were generated to examine its physiological role in vivo...
- LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signalingHui Wen Lue
Department of Biology, Georgia State University, Atlanta, Georgia, United States of America
PLoS ONE 6:e27720. 2011..of heparin binding-epidermal growth factor (HB-EGF) from ARCaP(E) cells that elicited constitutive epidermal growth factor receptor (EGFR) phosphorylation and its downstream extracellular signal regulated kinase (ERK) signaling...
- Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signalingSalvatore J Coniglio
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Mol Med 18:519-27. 2012..Pharmacological inhibition of epidermal growth factor receptor (EGFR) strongly inhibited microglia-stimulated invasion...
- Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivoXianrong Zhang
Department of Orthopaedic Surgery, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Bone Miner Res 26:1022-34. 2011While the epidermal growth factor receptor (EGFR)-mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions in the development and homeostasis of the skeletal system has ..
- EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathwaysRisto Kajanne
Molecular Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
J Cell Physiol 212:489-97. 2007..The results indicate that ERK pathway and AP-1 are downstream effectors of the EGF-R-mediated MMP-3 expression and collagen contraction in fibroblasts...
- The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinaseN C Luetteke
Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill 27599 7295
Genes Dev 8:399-413. 1994..Because the wa-2 mutation was mapped previously to the vicinity of the EGF/TGF-alpha receptor (EGFR) gene on mouse chromosome 11, we hypothesized that the wa-2 phenotype might result from a defect in either the ..
- Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J miceCordelia J Barrick
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Toxicol Appl Pharmacol 228:315-25. 2008Molecule-targeted therapies like those against the epidermal growth factor receptor (EGFR) are becoming widely used in the oncology clinic...
- Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expressionXiwu Chen
Department of Medicine, Division of Nephrology, Medical Center North B3109, Vanderbilt University, Nashville, TN 37232, USA
Mol Cell Biol 30:3048-58. 2010..negatively regulates the generation of profibrotic reactive oxygen species (ROS) by inhibiting epidermal growth factor receptor (EGFR) activation; however, the mechanism by which it does this is unknown...
- Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptorDaekee Lee
Department of Genetics, University of North Carolina School of Medicine, CB 7264, Chapel Hill, North Carolina, 27599, USA
Mamm Genome 15:525-36. 2004..for dominant, visible mutations, exhibit a wavy coat similar to mice homozygous for the recessive Tgfa wa1 or Egfr wa2 alleles...
- Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in miceAditya Murthy
Ontario Cancer Institute, Toronto, Ontario, Canada
J Clin Invest 120:2731-44. 2010..Loss of Timp3 enhanced metalloproteinase-dependent EGFR signaling due to increased release of the EGFR ligands TGF-alpha, amphiregulin, and HB-EGF, while depletion of shed ..
- Compromised reproductive function in adult female mice selectively expressing mutant ErbB-1 tyrosine kinase receptors in astrogliaBiao Li
Center for Human Molecular Genetics, Munroe Meyer Institute and Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5455, USA
Mol Endocrinol 17:2365-76. 2003The ErbB-1 tyrosine kinase receptor plays critical roles in regulating physiological functions...
- Regulation of cytokine receptors by Golgi N-glycan processing and endocytosisEmily A Partridge
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
Science 306:120-4. 2004..Thus, conditional regulation of N-glycan processing drives synchronous modification of cytokine receptors, which balances their surface retention against loss via endocytosis...
- Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signalingLamis Hammoud
Department of Physiology, Univ of Western Ontario, London, Ontario, Canada N6A 5C1
Am J Physiol Cell Physiol 296:C735-45. 2009..A TIMP-3/epidermal growth factor (EGF) receptor (EGFR)/c-Jun NH(2)-terminal kinase (JNK)/SP-1/p27 pathway was investigated...
- Kappa opioid receptor contributes to EGF-stimulated neurite extension in developmentNien Pei Tsai
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 107:3216-21. 2010..EGF and activated EGF receptor (EGFR) levels are elevated in embryonic spinal cords during late gestation stages, with concurrent rise in protein levels ..
- Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signalingCharlotte L Mattsson
Department of Physiology, The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
Biochim Biophys Acta 1803:983-9. 2010..Thus, in brown adipocytes, Cav1 is apparently required for an intact response to adenylyl cyclase-linked agonists/activators, whereas other signaling pathways examined function without Cav1...
- Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferationMarion A Cooley
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
Dev Dyn 241:303-14. 2012..Here we investigated the involvement of fibulin-1 in ADAMTS1-mediated cleavage of versican in vitro, and the involvement of fibulin-1 in versican cleavage in ventricular morphogenesis...
- Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during developmentM Cristina Ortega
Grupo de Neurobiología del Desarrollo GNDe, Hospital Nacional de Paraplejicos, Toledo, Spain
Exp Neurol 235:610-20. 2012..The present findings reveal a new role for Nrg1/ErbB4 signaling in regulating OPC migration selectively during early stages of CNS development...
- c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cellsHsi Lung Hsieh
Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Tao Yuan, Taiwan
J Neuroinflammation 9:152. 2012..However, the signaling mechanisms underlying ET-1-induced COX-2 expression in brain microvascular endothelial cells remain unclear...
- Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signalingMeei Hua Lin
Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Dev Biol 344:707-19. 2010..and Epgn) showed increased expression that was associated with elevated epidermal activation of the EGF receptor (EGFR) and STAT3, a downstream effector of EGFR signaling...
- Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease modelsHaruhisa Inoue
Neuroregeneration Laboratories, Udall Parkinson s Disease Center of Excellence, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 104:14430-5. 2007..protein LINGO-1 is associated with the Nogo-66 receptor complex and is endowed with a canonical EGF receptor (EGFR)-like tyrosine phosphorylation site...
- High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependentMarlon R Schneider
Institute of Molecular Animal Breeding and Biotechnology, Gene Center, and Department of Veterinary Sciences, LMU Munich, Munich, Germany
J Bone Miner Res 24:455-67. 2009Signaling through the epidermal growth factor receptor (EGFR) by ligands such as epidermal growth factor (EGF), transforming growth factor alpha (TGFA), and amphiregulin (AREG) has been reported to have effects on skeletal growth...
- Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissuesE A Berkowitz
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill 27599 7295, USA
Cell Growth Differ 7:1271-82. 1996..hybridization localized TGF-alpha expression to the advancing margins of the eyelid epithelium and epidermal growth factor receptor expression throughout the eyelid and corneal epithelia...
- Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal developmentJ F Wiesen
Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
Development 126:335-44. 1999..To determine the role of signaling through the EGF receptor (EGFR) in mammary ductal growth and branching, we used mice with a targeted null mutation in the Egfr...
- Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular glandYuji Miyazaki
Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
Dev Dyn 230:591-6. 2004Dimerization and activation of ErbB receptors by their ligands play crucial roles in organogenesis...
- Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesisBenjamin C Ling
Departments of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Cancer Cell 7:65-75. 2005..The epidermal growth factor receptor is not expressed by normal Schwann cells, yet is overexpressed in subpopulations of Nf1 mutant ..
- Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growthQiyu Feng
Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
Nat Cell Biol 8:945-56. 2006Cool-1 (cloned-out of library 1) has a key role in regulating epidermal growth factor receptor (EGFR) degradation...
- Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cellsBaifang Zhang
Division of Nephrology, McMaster University, and St Joseph s Hospital, Hamilton, Ontario, Canada
Cell Signal 19:1690-700. 2007..Akt activation was, however, mediated by transactivation of the epidermal growth factor receptor (EGFR), and this required receptor kinase activity since Akt activation did not occur in cells ..
- TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signalingRohan Samarakoon
Albany Medical College, Center for Cell Biology and Cancer Research, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
J Mol Cell Cardiol 44:527-38. 2008..established line (R22) of vascular smooth muscle cells (VSMC) was completely blocked by inhibition of epidermal growth factor receptor (EGFR) activity or adenoviral delivery of a kinase-dead EGFR(K721A) construct...
- Transactivation of the epidermal growth factor receptor is involved in the lutropin receptor-mediated down-regulation of ovarian aromatase expression in vivoNebojsa Andric
Department of Pharmacology, 2 319B BSB, 51 Newton Road, The University of Iowa, Iowa City, Iowa 52242, USA
Mol Endocrinol 24:552-60. 2010..evidence that down-regulation of Cyp19a1 by the LH surge requires efficient signaling through the epidermal growth factor receptor (EGFR)...
- Epstein-Barr virus latent membrane protein 1 modulates distinctive NF- kappaB pathways through C-terminus-activating region 1 to regulate epidermal growth factor receptor expressionChe Pei Kung
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Virol 84:6605-14. 2010..The epidermal growth factor receptor (EGFR) is highly induced by LMP1-CTAR1 in epithelial cells through activation of a novel NF-kappaB ..
- Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LHRachael P Norris
Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
Reproduction 140:655-62. 2010..b>Epidermal growth factor receptor (EGFR) activation is an essential step in triggering LH-induced meiotic resumption, but its ..
- Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signalingC S Rani
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, D C 20007, USA
J Biol Chem 272:10777-83. 1997..Thus, regulation of sphingosine kinase activity defines divergence in signal transduction pathways of PDGF and EGF receptors leading to mitogen-activated protein kinase activation...
- Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damageDaekee Lee
Department of Genetics, CB 7264, University of North Carolina, Chapel Hill, NC 27599, USA
Mol Cell Biol 24:8907-16. 2004..However, Ereg null mice are highly susceptible to cancer-predisposing intestinal damage caused by oral administration of dextran sulfate sodium...
- The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4D J Riese
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
J Biol Chem 271:20047-52. 1996..However, the ability of these ligands to activate all four erbB family receptors has not been evaluated...
- Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationJ Grimm
Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
J Cell Biol 154:345-54. 2001..Thus, we have identified a subclass of p62dok proteins that are putative links with downstream effectors of c-Ret in neuronal differentiation...
- Constitutive EGFR signaling confers a motile phenotype to neural stem cellsJohn A Boockvar
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Mol Cell Neurosci 24:1116-30. 2003The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration...
- Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cellsKazuhiro Aoki
Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
Mol Biol Cell 16:2207-17. 2005..These observations demonstrated for the first time that Vav2 and Vav3 are essential constituents of the positive feedback loop that is comprised of PI3-kinase and Rac1/Cdc42 and cycles locally with morphological changes...
- In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neuronsY Abe
Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Chuo Ku, Niigata 951 8585, Japan
Neuroscience 161:95-110. 2009..The robust and restricted expression of ErbB4 mRNA in the midbrain dopaminergic neurons suggests that ErbB4 ligands, neuregulin-1 and other EGF-related molecules, contribute to development or maintenance of this neuronal population...
- Signal transduction by receptors with tyrosine kinase activityA Ullrich
Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
Cell 61:203-12. 1990
- Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structureR Murillas
Department of Cell and Molecular Biology, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas CIEMAT, Madrid, Spain
EMBO J 14:5216-23. 1995b>Epidermal growth factor receptor (EGFR) is a key regulator of keratinocyte biology. However, the physiological role of EGFR in vivo has not been well established...
- Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptorP J Miettinen
Department of Growth and Development, University of California, San Francisco 94143 0640, USA
Nature 376:337-41. 1995..We find that EGF-R-/- mice survive for up to 8 days after birth and suffer from impaired epithelial development in several organs, including skin, lung and gastrointestinal tract...
- Epidermal growth factor receptor expression is abnormal in murine polycystic kidneyS A Orellana
Department of Pediatrics, University of Washington, Children s Hospital and Medical Center, Seattle, USA
Kidney Int 47:490-9. 1995..Therefore, renal expression of EGF receptor (EGFR) protein and mRNA was examined in an animal model for ARPKD, the C57BL/6Jcpk/cpk (CPK) mouse...
- Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase SypG S Feng
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
Oncogene 9:1545-50. 1994..The mouse Syp gene has been mapped to chromosome 5F region by the fluorescence in situ hybridization. These findings suggest specific functions for Syp in signal transduction downstream of receptor tyrosine kinases...
- Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair developmentL A Hansen
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892 0001, USA
Am J Pathol 150:1959-75. 1997Mice harboring a targeted disruption of the epidermal growth factor receptor (EGFR) allele exhibit a severely disorganized hair follicle phenotype, fuzzy coat, and systemic disease resulting in death before 3 weeks...
- Impaired lung branching morphogenesis in the absence of functional EGF receptorP J Miettinen
Department of Growth and Development, University of California at San Francisco, 94143, USA
Dev Biol 186:224-36. 1997..Taken together, our data indicate that signal transduction through the EGF receptor plays a major role in lung development and that its inactivation leads to a respiratory distress-like syndrome...
- A strain-independent postnatal neurodegeneration in mice lacking the EGF receptorM Sibilia
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
EMBO J 17:719-31. 1998Mice lacking the epidermal growth factor receptor (EGFR) exhibit strain-dependent phenotypes ranging from placental to postnatal skin, lung and brain defects...
- Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney diseaseW G Richards
Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
J Clin Invest 101:935-9. 1998..mouse models of autosomal recessive polycystic kidney disease (ARPKD) is an increased activity of the epidermal growth factor receptor (EGFR) in the affected kidneys...
- Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptorH I Kornblum
Department of Molecular and Medical Pharmacology, Brain Research Institute, University of California, Los Angeles School of Medicine, 90095, USA
J Neurosci Res 53:697-717. 1998Stimulation of the epidermal growth factor receptor (EGF-R) produces numerous effects on central nervous system (CNS) cells in vitro including neuronal survival and differentiation, astrocyte proliferation and the proliferation of ..
- Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesisB Chen
Cancer Biology Program, Hematology Oncology Division, Boston, Massachusetts, USA
Nat Genet 24:296-9. 2000..During studies of genetic interaction between Egfr, encoding the epidermal growth factor receptor, and Ptpn11, encoding the protein-tyrosine-phosphatase Shp2, we discovered that Egfr is required for ..
- The EGF receptor provides an essential survival signal for SOS-dependent skin tumor developmentM Sibilia
Research Institute of Molecular Pathology, Vienna, Austria
Cell 102:211-20. 2000The EGF receptor (EGFR) is required for skin development and is implicated in epithelial tumor formation...
- EGFRs mediate chemotactic migration in the developing telencephalonD Caric
Department of Neurobiology and Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, W1454 Biomedical Science Tower, Pittsburgh, PA 15261, USA
Development 128:4203-16. 2001..Cells that express high levels of EGFR are located in migration pathways, including the tangential pathway to the olfactory bulb via the rostral migratory ..
- Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesisReade B Roberts
Department of Cell Biology, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 99:1521-6. 2002We used the hypomorphic Egfr(wa2) allele to genetically examine the impact of impaired epidermal growth factor receptor (Egfr) signaling on the Apc(Min) mouse model of familial adenomatous polyposis...
- Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availabilitySusan Wohler Sunnarborg
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
J Biol Chem 277:12838-45. 2002..Consistent with the hypothesis that TACE regulates EGF receptor (EGFR) ligand availability in vivo, mice heterozygous for Tace and homozygous for an impaired EGFR allele (wa-2) were ..
- Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodiesKarianne E Longva
Institute of Pathology, The University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
J Cell Biol 156:843-54. 2002EGF, but not TGF alpha, efficiently induces degradation of the EGF receptor (EGFR)...
- A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesisM Llanos Casanova
Project on Cell and Molecular Biology and Gene Therapy, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, 28040 Madrid, Spain
Cancer Res 62:3402-7. 2002b>Epidermal growth factor receptor (EGFR) plays a critical role in epidermal biology. Abnormal EGFR function has been described in epithelial tumors including those induced by two-stage chemical carcinogenesis in mouse skin...
- ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ cultureMari Anne Huotari
Biomedicum Helsinki, Program for Developmental and Reproductive Biology and Haartman Institute, University of Helsinki, Helsinki 00014, Finland
Endocrinology 143:4437-46. 2002..growth factor (EGF) family of growth factors consists of several ligands that specifically activate four erbB receptor-tyrosine kinases, namely erbB-1 (EGF-R), erbB-2 (neu), erbB-3, and erbB-4...
- Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart functionRyo Iwamoto
Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 100:3221-6. 2003..HB-EGF-ErbB interactions in the heart were examined in vivo by administering HB-EGF to WT mice...
- Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signalingLeslie F Jackson
Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
EMBO J 22:2704-16. 2003Heparin-binding epidermal growth factor (HB-EGF) and betacellulin (BTC) are activating ligands for EGF receptor (EGFR/ErbB1) and ErbB4...
- Leukotrienes mediate part of Ova-induced lung effects in mice via EGFRB Boris Vargaftig
Unite de Pathogenie Microbienne Moleculaire, Unité Associée Institut Pasteur INSERM U389, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
Am J Physiol Lung Cell Mol Physiol 285:L808-18. 2003..Because mucus accumulation is regulated via the EGF receptor (EGFR), which is also implicated in the effects of LT, we studied this pathway with AG-1478, an EGFR tyrosine kinase ..
- Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitmentKe Wang
Department of Medicine, University of California, San Francisco, CA 94143, USA
J Biol Chem 279:53848-56. 2004The epidermal growth factor receptor (EGFR) and its ligands function in diverse cellular functions including cell proliferation, differentiation, motility, and survival...
- erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive functionVincent Prevot
Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Sciences Unversity, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
Endocrinology 146:1465-72. 2005..To generate animals carrying functionally impaired erbB-1 and erbB-4 receptors, we crossed Waved 2 (Wa-2+/+) mice harboring a point mutation of the erbB-1 receptor with mice expressing a dominant-negative erbB-4 ..
- Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactionsIrina J Fox
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
J Neurosci Res 79:584-97. 2005The ErbB family, ErbB1 (also known as the epidermal growth factor receptor EGFR), ErbB2, ErbB3, and ErbB4 comprise a group of receptor tyrosine kinases that interact with ligands from the epidermal growth factor (EGF) superfamily, ..
- Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cellsYu Sun
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
Neuron 45:873-86. 2005..We have found that in mouse embryonic forebrain ventricular and subventricular zones, the EGFR can distribute asymmetrically during mitosis in vivo and in vitro...
- Prospective isolation of late development multipotent precursors whose migration is promoted by EGFRFrancesca Ciccolini
Department of Neurobiology, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
Dev Biol 284:112-25. 2005..Here, we exploited the increase in EGF receptor (EGFR) levels, that occurs in late development stem cells or in younger precursors upon exposure to FGF-2, to isolate ..
- Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulinMark D Sternlicht
Department of Anatomy, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Development 132:3923-33. 2005..Postnatal mammary gland development requires epidermal growth factor receptor (EGFR) and its ligand amphiregulin (AREG), which generally must be cleaved from its transmembrane ..
- Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via an Src-dependent p38 mitogen-activated protein kinase signaling pathwayFumi Mikami
Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles 90057, USA
J Biol Chem 280:36185-94. 2005b>Epidermal growth factor receptor (EGFR) has been shown to play important roles in regulating diverse biological processes, including cell growth, differentiation, apoptosis, adhesion, and migration...
- HB-EGF promotes epithelial cell migration in eyelid developmentNaoki Mine
Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamadaoka, Suita, Osaka 565 0871, Japan
Development 132:4317-26. 2005..Crosses between HB(del/del) mice and waved 2 mice, a hypomorphic EGFR mutant strain, indicate that HB-EGF and EGFR interact genetically in eyelid closure...
- EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycansVuk Koprivica
Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
Science 310:106-10. 2005..Here, we show that suppressing the kinase function of the epidermal growth factor receptor (EGFR) blocks the activities of both myelin inhibitors and chondroitin sulfate proteoglycans in ..
- Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signalsJeffrey W Tyner
Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 116:309-21. 2006..This chronic switch in epithelial behavior exhibits genetic susceptibility and depends on persistent activation of EGFR signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes ..
- Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cellsSrinivas Papaiahgari
Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
Antioxid Redox Signal 8:43-52. 2006..Likewise, the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, AG1478, blocked hyperoxia-stimulated Akt and ERK1/2 phosphorylation,..
- Neuregulin 1-erbB signaling is necessary for normal myelination and sensory functionSuzhen Chen
Division of Neuroscience, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 26:3079-86. 2006To investigate the role of erbB signaling in the interactions between peripheral axons and myelinating Schwann cells, we generated transgenic mice expressing a dominant-negative erbB receptor in these glial cells...
- Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathwayAna Torroglosa
Area de Fisiologia, Facultad de Medicina, Universidad de Cadiz, Plaza Falla 9, 11003 Cadiz, Spain
Stem Cells 25:88-97. 2007..Both exogenous and endogenous NO impaired the EGF-induced activation of the EGF receptor (EGFR) tyrosine kinase and prevented the EGF-induced Akt phosphorylation in neurosphere cells...
- Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growthPäivi J Miettinen
Program of Developmental and Reproductive Biology, Biomedicum Helsinki, Room B530b, P O Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
Diabetes 55:3299-308. 2006b>Epidermal growth factor receptor (EGF-R) signaling is essential for proper fetal development and growth of pancreatic islets, and there is also evidence for its involvement in beta-cell signal transduction in the adult...
- p38 kinase regulates epidermal growth factor receptor downregulation and cellular migrationMark R Frey
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA
EMBO J 25:5683-92. 2006..inhibition of p38 mitogen-activated protein kinase, we show that p38 is required for efficient EGF-induced EGFR destruction but not internalization...
- A functional role for EGFR signaling in myelination and remyelinationAdan Aguirre
Center for Neuroscience Research, Children s National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010 2970, USA
Nat Neurosci 10:990-1002. 2007..Using both gain- and loss-of-function approaches, we explored the role of epidermal growth factor receptor (EGFR) signaling in adult myelin repair and in oligodendrogenesis...
- Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating systemJennifer L Macdonald
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid, Box 8231, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 105:112-7. 2008....
- Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathwaySara Panigone
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford, University School of Medicine, Stanford, California 94305, USA
Mol Endocrinol 22:924-36. 2008..is the induction of epidermal growth factor (EGF)-like growth factors and transactivation of EGF receptor (EGFR) signaling...
- VEGF inhibition and renal thrombotic microangiopathyVera Eremina
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
N Engl J Med 358:1129-36. 2008..These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy...
- An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptorMegan E Cavet
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
FASEB J 22:3607-16. 2008..GPCR) kinase-2 interacting protein 1 (GIT1) is a multifunctional scaffolding protein that regulates epidermal growth factor receptor (EGFR) signaling pathways...
- Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signalingTacghee Yi
Department of Cell and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea
J Cell Physiol 217:409-22. 2008The epidermal growth factor receptor (EGFR) functions in various cellular physiological processes such as proliferation, differentiation, and motility...
- Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathologyMarlon R Schneider
Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Feodor Lynen Str 25, D 81377 Munich, Germany
Am J Pathol 173:14-24. 2008The epidermal growth factor receptor (EGFR) network, including its seven ligands and four related receptors, represents one of the most complex signaling systems in biology...
- The EGFR is required for proper innervation to the skinAdel Maklad
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
J Invest Dermatol 129:690-8. 2009b>EGFR family members are essential for proper peripheral nervous system development. A role for EGFR itself in peripheral nervous system development in vivo, however, has not been reported...
- Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphologyShuta Ishibe
Section of Nephrology, Yale University School of Medicine, New Haven, CT 06510, USA
Development 136:337-45. 2009..Met(fl/fl);HoxB7-Cre;wa-2/wa-2 mice, which lack normal Egfr and Met signaling, exhibit small kidneys with a marked decrease in UB branching at E14...
- Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptorTang Cheng Lee
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Genesis 47:85-92. 2009The epidermal growth factor receptor (EGFR) is important for normal homeostasis in a variety of tissues and, when abnormally expressed or mutated, contributes to the development of many diseases...
- Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFRM E Evangelopoulos
Department of Neurology, Eginitio Hospital, University of Athens, Athens, Greece
J Neurosci Res 87:2138-44. 2009..Interestingly, we found that mevastatin triggered phosphorylation of the key kinases epidermal growth factor receptor (EGFR), ERK1/2, and Akt/protein kinase B...
- Clozapine-induced ERK1 and ERK2 signaling in prefrontal cortex is mediated by the EGF receptorAvril Pereira
Department of Molecular Psychopharmacology, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, 3052, Victoria, Australia
J Mol Neurosci 39:185-98. 2009..protein kinase extracellular signal-regulated kinase (MAPK-ERK) cascade that links G-protein-coupled receptor and ErbB growth factor signaling systems, thereby regulating synaptic plasticity and connectivity, processes impaired in ..
- Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasisNili Jin
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Development 136:3347-56. 2009..Knockdown of MIG-6 in H441 human bronchiolar epithelial cells increased phospho-EGFR and phospho-AKT levels as well as cell proliferation, whereas knockdown of MIG-6 in human lung microvascular ..
- The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradationYa sheng Gao
Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
J Biol Chem 285:11219-26. 2010..Here, we show that HDAC6 associates with the endosomal compartments and controls epidermal growth factor receptor (EGFR) trafficking and degradation. We found that loss of HDAC6 promoted EGFR degradation...
- TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formationXiping Cheng
The Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, 3089 Natural Science Building Kraus, 830 North University, Ann Arbor, MI 48109, USA
Cell 141:331-43. 2010..hair phenotypes in mice result from naturally occurring loss-of-function mutations in the genes for TGF-alpha and EGFR. Conversely, excessive activities of TGF-alpha/EGFR result in hairless phenotypes and skin cancers...
- Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signalingSacri R Ferron
Departamento de Biología Celular and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universidad de Valencia, 46100 Burjassot, Spain
Cell Stem Cell 7:367-79. 2010..dual-specificity kinase Dyrk1A is part of a molecular pathway involved in the regulation of biased epidermal growth factor receptor (EGFR) signaling in the progeny of dividing neural stem cells (NSC) of the adult subependymal zone (..
- Notch and EGFR pathway interaction regulates neural stem cell number and self-renewalAdan Aguirre
Center for Neuroscience Research, Children s National Medical Center, Washington, District of Columbia 20010, USA
Nature 467:323-7. 2010..EGFR (epidermal growth factor receptor) and Notch signalling pathways have fundamental roles during development of multicellular organisms...
- Glucocorticoid receptor antagonizes EGFR function to regulate eyelid developmentAna Sanchis
Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas IBV CSIC, Valencia, Spain
Int J Dev Biol 54:1473-80. 2010..These defects are due, at least in part, to the lack of antagonism between GR and epidermal growth factor receptor (EGFR) signaling, causing sustained activation of the MAPK/AP-1 pathway and the upregulation of ..
- Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/saltViolaine Griol-Charhbili
Centre de Recherche des Cordeliers, Paris, France
Hypertension 57:238-44. 2011..Activation of the epidermal growth factor receptor (EGFR) is thought to mediate the vascular effects of aldo, but this has yet to be demonstrated in ..
- A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradationChengliang Zhang
Department of Biomedical and Integrative Physiology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 286:9373-81. 2011Activated epidermal growth factor receptor (EGFR) continues to signal in the early endosome, but how this signaling process is regulated is less well understood...
- Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligationE Hakonen
Research Programs Unit, Molecular Neurology, Biomedicum Stem Cell Centre, University of Helsinki, PO Box 63, Haartmaninkatu 8, 00014 Helsinki, Finland
Diabetologia 54:1735-43. 2011b>Epidermal growth factor receptor (EGFR) signalling is essential for the proper fetal development of pancreatic islets and in the postnatal formation of an adequate beta cell mass...
- Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1Barbara Schreier
Julius Bernstein Institute of Physiology, University of Halle Wittenberg, Halle, Germany
Arterioscler Thromb Vasc Biol 31:1643-52. 2011Pathophysiological effects of the epidermal growth factor receptor (EGFR or ErbB1) include vascular remodeling...
- Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturationMinnie Hsieh
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e21574. 2011..that luteinizing hormone (LH) stimulation of ovulatory follicles causes transactivation of the epidermal growth factor receptor (EGFR) has provided insights into the mechanisms of ovulation...
- The critical role of the epidermal growth factor receptor in endochondral ossificationXianrong Zhang
Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Bone Miner Res 26:2622-33. 2011Loss of epidermal growth factor receptor (EGFR) activity in mice alters growth plate development, impairs endochondral ossification, and retards growth...
- Ligand binding induces a conformational change in epidermal growth factor receptor dimersFrancesca Walker
Ludwig Institute for Cancer Research Melbourne Parkville Branch, Australia
Growth Factors 30:394-409. 2012The activation of the epidermal growth factor receptor (EGFR) kinase requires ligand binding to the extracellular domain (ECD)...
- THE BIOLOGY OF PROGRESSIVE NEPHRON DESTRUCTIONRaymond Harris; Fiscal Year: 2007..abstract_text> ..
- Dedifferentiation Following Renal Cell InjuryShougang Zhuang; Fiscal Year: 2009..morphology and express vimentin, a marker of dedifferentiated epithelial cells;2) p38 and the epidermal growth factor receptor (EGFR) are activated after oxidant injury to RPTC;3) inhibition of p38 blocks EGFR phosphorylation;..
- EPITHELIAL/MESENCHYMAL INTERACTIONS IN LUNG DEVELOPMENTFarrah Kheradmand; Fiscal Year: 2002..Michael Mafthay, Carol Basbaum, and Gerald Cunha, all senior faculty members of Division of Pulmonary and Department of Anatomy at UCSF. (End of Abstract) ..
- Role of TGF-Alpha in Pulmonary Vascular DiseaseTIMOTHY LE CRAS; Fiscal Year: 2006..This information will serve as a basis for developing therapeutic strategies aimed at improving lung growth and preventing pulmonary hypertension in premature babies and adults. ..
- Lipid Rafts and Cell FunctionLinda Pike; Fiscal Year: 2006..and, iv) the role of rafts in endocytosis and protein processing. [unreadable] [unreadable]..
- The Role of Proteinases in Experimental AsthmaFarrah Kheradmand; Fiscal Year: 2006..Together these findings will substantially contribute to the understanding of regulation of Th2 immunity and will provide new approaches for the treatment of asthma. [unreadable] [unreadable] [unreadable]..
- Regulation of Progenenitor Cell Maturation in the CortexLaura Lillien; Fiscal Year: 2007..These cells are of particular interest for several reasons. The EGFR-hi subset is heterogeneous and includes multipotent stem cells...
- The Role of Proteases in Lung Inflammation & RemodelingFarrah Kheradmand; Fiscal Year: 2007..This work may serve as the foundation for future therapeutic studies that target a broad range of asthmatic patients. ..
- Viral-induced T Cell Responses in COPD ExacerbationFarrah Kheradmand; Fiscal Year: 2009....
- Lipid Rafts and EGF Receptor FunctionLINDA JOY PIKE; Fiscal Year: 2010....
- Immune modulators of inflammation in servere COPDFarrah Kheradmand; Fiscal Year: 2010..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with COPD and emphysema. ..