Egf

Summary

Gene Symbol: Egf
Description: epidermal growth factor
Alias: AI790464, pro-epidermal growth factor, Pro-epidermal growth factor precursor (EGF)
Species: mouse

Top Publications

  1. ncbi Stimulatory effect of epidermal growth factor on the development of mouse early embryos in vitro
    T M Kuo
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    Endocrinol Jpn 38:485-90. 1991
  2. ncbi Assessment of transcript polyadenylation by 3' RACE: the response of epidermal growth factor messenger ribonucleic acid to thyroid hormone in the thyroid and submaxillary glands
    L G Sheflin
    Buffalo Veterans Affairs Medical Center, New York 14215, USA
    Endocrinology 136:5666-76. 1995
  3. ncbi Neurotrophic actions of a novel molluscan epidermal growth factor
    P M Hermann
    Department of Physiology and Biophysics, Neuroscience Research Group, University of Calgary, Calgary, Alberta, T2N 4N1 Canada
    J Neurosci 20:6355-64. 2000
  4. ncbi Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha
    P L Bryant
    Environmental Sciences and Engineering Department, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 62:103-14. 2001
  5. pmc Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling
    Salvatore J Coniglio
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Med 18:519-27. 2012
  6. doi EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth
    Frédéric Bouchard
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, QC
    Blood 116:759-66. 2010
  7. doi MAPK/ERK and Wnt/β-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells
    Caixia Jin
    Department of Surgery, University of North Carolina at Chapel Hill, NC, United States
    Biochem Biophys Res Commun 409:803-7. 2011
  8. ncbi Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
    M L Mucenski
    NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
    Oncogene Res 2:219-33. 1988
  9. ncbi The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF
    M Kashimata
    Department of Pharmacology, Meikai University, Saitama, Sakado, Japan
    Dev Biol 220:183-96. 2000
  10. ncbi Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene
    C Bartholomew
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    Oncogene 4:529-34. 1989

Research Grants

  1. ERBB REGULATION OF BREAST DEVELOPMENT AND TUMORIGENESI
    David Lee; Fiscal Year: 2004
  2. Lipid Rafts and Cell Function
    Linda Pike; Fiscal Year: 2006
  3. Lipid Rafts and EGF Receptor Function
    LINDA JOY PIKE; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. ncbi Stimulatory effect of epidermal growth factor on the development of mouse early embryos in vitro
    T M Kuo
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    Endocrinol Jpn 38:485-90. 1991
    Effects of epidermal growth factor (EGF) on the development of mouse 2-cell embryos cultured in vitro were investigated. The addition of EGF at a concentration of 0...
  2. ncbi Assessment of transcript polyadenylation by 3' RACE: the response of epidermal growth factor messenger ribonucleic acid to thyroid hormone in the thyroid and submaxillary glands
    L G Sheflin
    Buffalo Veterans Affairs Medical Center, New York 14215, USA
    Endocrinology 136:5666-76. 1995
    The complementary DNA (cDNA) sequence of epidermal growth factor (EGF) indicates that its 3' untranslated region (3' UTR) is 745 bases long, with polyadenylation occurring at residue 4749...
  3. ncbi Neurotrophic actions of a novel molluscan epidermal growth factor
    P M Hermann
    Department of Physiology and Biophysics, Neuroscience Research Group, University of Calgary, Calgary, Alberta, T2N 4N1 Canada
    J Neurosci 20:6355-64. 2000
    The mammalian epidermal growth factor (EGF) is expressed in the developing and adult CNS, and it has been implicated in the control of cell proliferation, differentiation, and neurotrophic events...
  4. ncbi Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha
    P L Bryant
    Environmental Sciences and Engineering Department, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 62:103-14. 2001
    ..These responses are correlated with disruption of expression of epidermal growth factor (EGF) receptor ligands, primarily EGF and transforming growth factor-alpha (TGF-alpha), and altered epithelial cell ..
  5. pmc Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling
    Salvatore J Coniglio
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Med 18:519-27. 2012
    ..cells were found to constitutively secrete CSF-1, the levels of which were unaffected by epidermal growth factor (EGF) stimulation, EGFR inhibition or coculture with microglia...
  6. doi EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth
    Frédéric Bouchard
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, QC
    Blood 116:759-66. 2010
    ..that EGR-1 expression is induced in stromal cells after contact with lymphoma cells via epidermal growth factor (EGF)...
  7. doi MAPK/ERK and Wnt/β-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells
    Caixia Jin
    Department of Surgery, University of North Carolina at Chapel Hill, NC, United States
    Biochem Biophys Res Commun 409:803-7. 2011
    ..Epidermal growth factor (EGF) supplementation shows a significant increase in Sca-1(+) HPC proliferation and colony formation while stimulating ..
  8. ncbi Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
    M L Mucenski
    NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
    Oncogene Res 2:219-33. 1988
    ..The chromosomal location of the proto-oncogene Nras, and two growth factors, epidermal growth factor (Egf), and the beta subunit of nerve growth factor (Ngfb), which had previously been assigned to Chromosome 3 by somatic ..
  9. ncbi The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF
    M Kashimata
    Department of Pharmacology, Meikai University, Saitama, Sakado, Japan
    Dev Biol 220:183-96. 2000
    We have previously reported that epidermal growth factor (EGF) stimulates branching morphogenesis of the fetal mouse submandibular gland (SMG) (M. Kashimata and E. W. Gresik, 1997, Dev. Dyn...
  10. ncbi Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene
    C Bartholomew
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    Oncogene 4:529-34. 1989
    ..These results demonstrate that the CB-1/Fim-3 and Evi-1 loci constitute a large genomic region in which viral integrations activate the transcription of a new potential myeloid transforming gene...
  11. ncbi Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1
    W S Moseley
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 5:899-905. 1989
    ..These studies provide a model for examination of specific evolutionary events...
  12. ncbi Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form
    A G Kumar
    Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030
    J Immunol 153:4088-98. 1994
    ..Thus, expression of VCAM-1 is restricted and controlled at the level of transcription and by alternative splicing...
  13. ncbi Messenger ribonucleic acid for transforming growth factor-alpha, but not for epidermal growth factor, is expressed in fetal and neonatal mouse brain
    J Yeh
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115
    Am J Obstet Gynecol 167:242-5. 1992
    ....
  14. ncbi Lactogenic hormones increase epidermal growth factor messenger RNA content of mouse mammary glands
    S E Fenton
    Endocrinology Reproductive Physiology Program, University of Wisconsin, Madison 53706
    Biochem Biophys Res Commun 181:1063-9. 1991
    Epidermal growth factor (EGF) is known to stimulate mammary epithelial proliferation, has been identified in milk and is expressed in lactating mammary epithelia. This study examined hormonal control of EGF mRNA in mammary glands of mice...
  15. ncbi Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues
    L B Rall
    Nature 313:228-31. 1985
    Epidermal growth factor (EGF), a protein comprising 53 amino acids, is derived from a precursor of 1,217 amino acids that includes at least seven EGF-like sequences...
  16. ncbi Epidermal growth factor. Location of disulfide bonds
    C R Savage
    J Biol Chem 248:7669-72. 1973
  17. pmc Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development
    E Nexø
    Proc Natl Acad Sci U S A 77:2782-5. 1980
    ..and a radioreceptor assay, we have estimated the content of mouse epidermal growth factor-urogastrone (EGF-URO) in fetal mice at 11(1/2) to 17(1/2) days of gestation...
  18. pmc Murine epidermal growth factor: heterogeneity on high resolution ion-exchange chromatography
    A W Burgess
    EMBO J 2:2065-9. 1983
    We have shown that epidermal growth factor (EGF) purified either by the classical method of Savage and Cohen, or solely by h.p.l.c. techniques can be resolved into two species, EGF alpha and EGF beta...
  19. ncbi Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth
    D A Hinton
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Exp Cell Res 219:640-9. 1995
    ..Evidence is presented suggesting that surface GalTase interacts with the epidermal growth factor (EGF) receptor, as suggested by others...
  20. ncbi Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF
    T J Kilpatrick
    Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Australia
    J Neurosci 15:3653-61. 1995
    Fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF) have both been reported to stimulate precursors in the developing CNS...
  21. ncbi Effects of epidermal growth factor on the growth and differentiation of cultured mouse ovarian follicles
    N I Boland
    Department of Physiology, University Medical School, Edinburgh, UK
    J Reprod Fertil 101:369-74. 1994
    The aim of this investigation was to determine the influence of epidermal growth factor (EGF) on follicular growth and steroidogenesis in mice...
  22. ncbi An inborn error in epidermal growth factor prohormone metabolism in a mouse model of autosomal recessive polycystic kidney disease
    J Lakshmanan
    Department of Pediatrics, Harbor UCLA Medical Center, Torrance 90509
    Biochem Biophys Res Commun 196:892-901. 1993
    The C57BL/6J CPK heterozygous breeders secrete in urine a variant EGF-prohormone with a molecular mass of 154 kDa in addition to the normal 165 kDa EGF-prohormone...
  23. ncbi The distribution of epidermal growth factor binding sites in the developing mouse palate
    C L Brunet
    Department of Cell and Structural Biology, University of Manchester, United Kingdom
    Int J Dev Biol 37:451-8. 1993
    The distribution of epidermal growth factor (EGF) receptors in the developing mouse palate was mapped using 125I-EGF labeling of paired palate organ cultures...
  24. ncbi Expression of alternatively spliced epidermal growth factor-like domains in aggrecans of different species. Evidence for a novel module
    C Fulop
    Department of Biochemistry, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612
    J Biol Chem 268:17377-83. 1993
    ..domain of human aggrecan has been shown previously to contain an alternatively spliced epidermal growth factor (EGF)-like module...
  25. ncbi Transforming growth factor beta 1-induced delay of cell cycle progression and its association with growth-related gene expression in mouse fibroblasts
    T A Kim
    Department of Biochemistry, Roswell Park Cancer Institute, Buffalo, NY 14263
    Cancer Lett 71:125-32. 1993
    TGF beta-induced cell cycle progression is relatively slower than that induced by EGF or PDGF-BB. Further, TGF beta delays EGF or PDGF-induced 5-phase entry in C3H 10T1/2 mouse fibroblasts...
  26. ncbi The mouse BP-1 gene: structure, chromosomal localization, and regulation of expression by type I interferons and interleukin-7
    J Wang
    Howard Hughes Medical Institute, University of Alabama at Birmingham 35294, USA
    Genomics 33:167-76. 1996
    ..This finding indicates that the upregulated BP-1 expression can be disassociated from the cell growth signal...
  27. ncbi The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4
    D J Riese
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 271:20047-52. 1996
    The epidermal growth factor (EGF) family hormones amphiregulin (AR), transforming growth factor-alpha (TGF-alpha), and heparin-binding EGF-like growth factor (HB-EGF) are thought to play significant roles in the genesis or progression of ..
  28. ncbi Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development
    D Z Wang
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Genes Dev 11:309-20. 1997
    ..fibroblasts showed reduced mitogen-activated protein kinase activation in response to epidermal growth factor (EGF)...
  29. pmc MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
    G R Fanger
    Division of Basic Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    EMBO J 16:4961-72. 1997
    ..MEKK1 and 2 were activated by EGF, and kinase-inactive mutants of each MEKK partially inhibited EGF-stimulated JNK activity...
  30. pmc The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis
    C T Kuo
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 11:2996-3006. 1997
    ..Therefore, LKLF defines a novel transcriptional pathway in which endothelial cells regulate the assembly of the vascular tunica media and concomitant vessel wall stabilization during mammalian embryogenesis...
  31. ncbi Specificity within the EGF family/ErbB receptor family signaling network
    D J Riese
    Department of Pathology, Yale University, New Haven, CT, USA
    Bioessays 20:41-8. 1998
    Recent years have witnessed tremendous growth in the epidermal growth factor (EGF) family of peptide growth factors and the ErbB family of tyrosine kinases, the receptors for these factors...
  32. ncbi Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis
    B Chen
    Cancer Biology Program, Hematology Oncology Division, Boston, Massachusetts, USA
    Nat Genet 24:296-9. 2000
    ....
  33. ncbi EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells
    Fiona Doetsch
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Neuron 36:1021-34. 2002
    ..SVZ cells exposed to EGF in culture grow to form neurospheres that are multipotent and self-renewing...
  34. pmc Synergistic suppression of apoptosis in salivary acinar cells by IGF1 and EGF
    K H Limesand
    Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Cell Death Differ 10:345-55. 2003
    ..IGF1 also suppressed apoptosis induced by taxol and brefeldin A. EGF was unable to suppress apoptosis induced by etoposide, but was able to synergize with IGF1 to further suppress ..
  35. ncbi EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland
    Noriko Koyama
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
    Dev Dyn 227:216-26. 2003
    Branching morphogenesis of fetal mouse submandibular glands (SMGs) partly depends on the epidermal growth factor (EGF) receptor that triggers at least three intracellular signaling pathways involving (1) the mitogen-activated protein ..
  36. ncbi Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells
    Danica Ramljak
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
    Exp Cell Res 287:397-410. 2003
    ..Our findings may be of importance for understanding the emerging role of Bcl-x(L) as a potential marker of poor prognosis in breast cancer...
  37. ncbi Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling
    Sachiko Kamakura
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 6:547-54. 2004
    ..These results suggest that direct protein-protein interactions coordinate cross-talk between the Notch-Hes and JAK-STAT pathways...
  38. ncbi A major quantitative trait locus on mouse chromosome 3 is involved in disease susceptibility in different colitis models
    Michelle E A Borm
    Department of Immunogenetics, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Gastroenterology 128:74-85. 2005
    ..Disease expression differs markedly between inbred strains of mice, indicating genetic control of disease susceptibility. We performed a genome-wide screen to localize the chromosomal regions regulating disease expression...
  39. ncbi Growth of intestinal epithelium in organ culture is dependent on EGF signalling
    Helen E Abud
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, PO Box 2008, Parkville, Victoria 3050, Australia
    Exp Cell Res 303:252-62. 2005
    ..This demonstrates an essential role for the EGF signalling pathway during the early stages of intestinal development.
  40. ncbi Localization of am3 using EL congenic mouse strains
    T Shimizu
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, 2 870 1 Sakaecho nishi, Chiba 271 8587, Japan
    J Dent Res 84:315-9. 2005
    ..These results confine the am3 locus to an approximately 4.4-cM region, and demonstrate that other unmapped genes are also involved in the absence of M3 in EL/Sea mice...
  41. ncbi HB-EGF decelerates cell proliferation synergistically with TGFalpha in perinatal distal lung development
    Seigo Minami
    Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Dev Dyn 237:247-58. 2008
    Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family of growth factors that is suggested to be involved in distal lung development...
  42. doi Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes
    Therese E Holmström
    Department of Physiology, The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Exp Cell Res 314:3581-92. 2008
    ..In primary cultures of mouse brown pre-adipocytes, both EGF (epidermal growth factor) and PDGF (platelet-derived growth factor) induced Erk1/2 activation...
  43. pmc Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation
    Eric Haines
    Hormones and Cancer Research Unit, Department of Medicine, McGill University, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 29:2505-20. 2009
    ..talk mechanism(s) downstream of prolactin (PRL), a primary differentiation hormone, and epidermal growth factor (EGF), an important proliferative factor, in mammary epithelial cell growth and differentiation...
  44. pmc Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux
    Xiaoye Zhou
    Colleges of Life Sciences, Nankai University, Tianjin 300071, China
    J Biol Chem 285:6316-26. 2010
    ..However, inhibition of ERK1/2 and activation of LXR synergistically induced macrophage cholesterol efflux and ABCA1 expression. Our data suggest that ERK1/2 activity can play an important role in macrophage cholesterol trafficking...
  45. pmc Involvement of beta1-integrin up-regulation in basic fibroblast growth factor- and epidermal growth factor-induced proliferation of mouse neuroepithelial cells
    Yusuke Suzuki
    Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 285:18443-51. 2010
    In neural stem cells, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) promote cell proliferation and self-renewal...
  46. doi IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses
    Jihye Lee
    Laboratory of Developmental Immunology, Japan Science and Technology Agency Core Research for Engineering, Science, and Technology, Graduate School of Frontier Biosciences, Osaka University, Osaka 565 0871, Japan
    J Immunol 189:1928-36. 2012
    ..From these results, we consider whether the IL-6 amplifier in grafts might be a valuable therapeutic target for the prevention of transplant rejection, including chronic rejection...
  47. doi Long-term estradiol exposure is a direct mitogen for insulin/EGF-primed endometrial cells and drives PTEN loss-induced hyperplasic growth
    Nuria Eritja
    Oncologic Pathology Group, Department of Basic Medical Sciences, University of Lleida, University Hospital Arnau de Vilanova, Lleida Institute for Biomedical Research IRBLleida, Lleida, Spain
    Am J Pathol 183:277-87. 2013
    ..between loss of PTEN, growth factors [eg, insulin/insulin-like growth factor (IGF)-1], epidermal growth factor (EGF), and hyperestrogenism in the development of endometrial carcinoma is still controversial...
  48. doi Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes
    Yakun Wang
    State Key Laboratory of Agrobiotechnology, College of Biological Science, China Agricultural University, 100193 Beijing, People s Republic of China
    Endocrinology 154:3401-9. 2013
    ..We investigated the regulatory mechanism of LH-activated epidermal growth factor (EGF) receptor signaling on NPR2 function...
  49. doi Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4 + cells recruited from bone marrow
    Takehito Sato
    Department of Pharmacology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami, Sagamihara, Kanagawa, 252 0374, Japan
    J Gastroenterol 49:455-69. 2014
    ..Recent results suggest that vascular endothelial growth factor receptor 1 (VEGFR1), which binds to VEGF, promotes angiogenesis. In the present study, we investigated the role of VEGFR1 signaling in gastric ulcer healing and angiogenesis...
  50. doi Epidermal growth factor enhances androgen receptor‑mediated bladder cancer progression and invasion via potentiation of AR transactivation
    Teng Fu Hsieh
    Sex Hormone Research Center and Graduate Institute of Clinical Medical Science, China Medical University Hospital, Taichung 404, Taiwan, R O C
    Oncol Rep 30:2917-22. 2013
    ..Epidermal growth factor (EGF), a key player in BCa progression, has been demonstrated to be able to potentiate AR transactivation in prostate ..
  51. pmc EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis
    Zhonghua Zhang
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229
    J Immunol 192:859-66. 2014
    Despite the important role for epidermal growth factor (EGF) in epithelial homeostasis and wound healing, it has not been investigated in atopic dermatitis (AD). We used AD animal models to explore the role of EGF in AD...
  52. pmc Ocular surface disease and dacryoadenitis in aging C57BL/6 mice
    Andrew J McClellan
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Houston, Texas
    Am J Pathol 184:631-43. 2014
    ..Taken together, our results indicate that age-related autoimmunity contributes to development of DED with aging. ..
  53. doi EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner
    Cai Xia Ma
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou, 450001, Henan, China
    Cell Mol Life Sci 72:2005-22. 2015
    ..Here, we have identified a GATA-4 target, EGF, which is essential for cardiogenesis and regulates cardiac differentiation in a dose- and time-dependent manner...
  54. doi Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion
    Yunpeng Xie
    Department of Biochemistry and Molecular Biology, Dalian Medical University, 116044, Dalian, Liaoning, People s Republic of China
    Cell Tissue Res 362:421-30. 2015
    ..However, little is known about the roles of FoxM1 in the invasion of EVT cells. EGF, as a growth factor (epidermal growth factor), has been studied extensively in reproduction...
  55. pmc VIP and growth factors in the infected cornea
    Xiaoyu Jiang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 52:6154-61. 2011
    ..However, whether VIP treatment modulates growth factors to promote healing in the infected cornea remains untested and is the purpose of this study...
  56. pmc EGF stimulates Müller glial proliferation via a BMP-dependent mechanism
    Yumi Ueki
    Department of Biological Structure, University of Washington, Seattle, Washington 98195, USA
    Glia 61:778-89. 2013
    ..Among these stimuli, EGF is known to be a potent mitogen for Müller glia...
  57. pmc ROS production as a common mechanism of ENaC regulation by EGF, insulin, and IGF-1
    Daria V Ilatovskaya
    Medical College of Wisconsin, Dept of Physiology, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Cell Physiol 304:C102-11. 2013
    ..ENaC activity is acutely upregulated by epidermal growth factor (EGF), insulin, and insulin-like growth factor-1 (IGF-1)...
  58. ncbi Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst
    A Dardik
    Department of Biology, University of Pennsylvania, Philadelphia 19104
    Dev Biol 154:396-409. 1992
    Results of previous studies suggested that responses of mouse blastocysts to TGF-alpha/EGF treatment are mediated by EGF receptors (EGFR) located on the apical surface of the trophectoderm (TE)...
  59. ncbi Reduced level of epidermal growth factor in the skeletal muscle of mice with muscular dystrophy
    M Hiramatsu
    Department of Dental Pharmacology, Meikai University School of Dentistry, Saitama, Japan
    Horm Metab Res 24:138-9. 1992
  60. ncbi Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints
    G T Montelione
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854 5635
    Biochemistry 31:236-49. 1992
    ..the present structure refinement (which we have deposited in the Brookhaven Protein Data Bank) are important data for understanding the structures of EGF-like proteins and for further detailed comparisons of these structures with mEGF.
  61. ncbi Localization of epidermal growth factor precursor in tooth and lung during embryonic mouse development
    M L Snead
    Department of Basic Sciences Biochemistry, University of Southern California, Los Angeles 90089 0191
    Dev Biol 134:420-9. 1989
    The murine epidermal growth factor (EGF) precursor is a 1217 amino acid protein which contains mature EGF (amino acid residues 977-1029) as well as eight EGF-like repeats...
  62. ncbi Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells
    J Massague
    J Biol Chem 258:13614-20. 1983
    ..properties of native eTGF has been prepared to characterize the interaction of eTGF with epidermal growth factor (EGF) membrane receptors...
  63. ncbi Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins
    J Scott
    Science 221:236-40. 1983
    The structure of the messenger RNA (mRNA) encoding the precursor to mouse submaxillary epidermal growth factor (EGF) was determined from the sequence of a set of overlapping complementary DNA's (cDNA)...
  64. ncbi Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues
    J A Abraham
    Scios Nova Inc, Mountain View, CA 94043
    Biochem Biophys Res Commun 190:125-33. 1993
    Clones were obtained that encode the rat and mouse forms of heparin-binding EGF-like growth factor (HB-EGF), a potent mitogen for smooth muscle cells, fibroblasts and keratinocytes that is proposed to be derived from a transmembrane ..
  65. ncbi Ontogenesis and distribution of epidermal growth factor immunoreactivity and binding activity in the mouse fetal and neonatal tissues
    H Shigeta
    Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan
    Endocr J 40:641-7. 1993
    Epidermal growth factor (EGF) immunoreactivity, EGF binding activity, and their ontogenic changes were investigated in placenta, amnion, and various organs of mouse fetus and neonate...
  66. ncbi Interdependence of epidermal growth factor and insulin-like growth factor-I expression in the mouse uterus
    V Hana
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Endocrinology 135:107-12. 1994
    Both epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) have been implicated as paracrine mediators of estrogen action in the rodent uterus...
  67. ncbi EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro
    L Shum
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 94143 0640
    Development 118:903-17. 1993
    Mutations associated with genes of the EGF superfamily are implicated in facial malformations arising from abnormal development of the first branchial arch...
  68. ncbi Growth factors and their receptors in development
    E D Adamson
    La Jolla Cancer Research Foundation, California 92037
    Dev Genet 14:159-64. 1993
  69. ncbi Effect of thyroid hormone on epidermal growth factor gene expression in mouse submandibular gland
    M Fujieda
    Department of Endocrinology and Metabolism, Nagoya University, Japan
    Endocrinology 132:121-5. 1993
    Epidermal growth factor (EGF) in mouse submandibular gland (SMG) is synthesized in the granular convoluted tubular (GCT) cells. The synthesis of EGF in SMG has been shown to be increased by thyroid hormone...
  70. ncbi Epidermal growth factor and platelet-derived growth factor regulate the activity of the insulin-like growth factor I gene promoter
    S Li
    Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Exp Gerontol 31:195-206. 1996
    ..We have now investigated the activity of the IGF-I promoter, in response to stimulation of cells by either PDGF or EGF. Both growth factors stimulate the activity of the IGF-I promoter, indicating that they regulate the levels of ..
  71. ncbi Immunohistochemical studies on the expression and estrogen dependency of EGF and its receptor and C-fos proto-oncogene in the uterus and vagina of normal and neonatally estrogen-treated mice
    L Falck
    Department of Anatomy, University of Lund, Sweden
    Anat Rec 245:459-71. 1996
    ..g., EGF) and proto-oncogenes (e.g., c-fos)...
  72. ncbi Glucocorticoids, tumor necrosis factor-alpha, and epidermal growth factor regulation of pulmonary morphogenesis: a multivariate in vitro analysis of their related actions
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
    Dev Dyn 205:365-78. 1996
    ..5-E12) cultured under defined conditions in the presence of single or combined CORT, TNF-alpha, and EGF supplementation...
  73. pmc Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor
    S W Curtis
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 93:12626-30. 1996
    Past studies have shown that epidermal growth factor (EGF) is able to mimic the uterotropic effects of estrogen in the rodent...
  74. ncbi Cell proliferation and expression of EGF, TGF-alpha, and EGF receptor in the developing primary palate
    A Iamaroon
    Department of Clinical Dental Sciences, University of British Columbia, Vancouver, Canada
    J Dent Res 75:1534-9. 1996
    Growth factors such as epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) play an important role in cell proliferation during embryogenesis...
  75. ncbi Epidermal growth factor and epidermal growth factor-receptor expression in the mouse dental follicle during tooth eruption
    B Shroff
    Department of Orthodontics, Dental School, UMAB 21201, USA
    Arch Oral Biol 41:613-7. 1996
    When the role of exogenous epidermal growth factor (EGF) during tooth eruption was first demonstrated it was strongly suggested that EGF was a natural regulator of eruption...
  76. ncbi Characterization of the mouse epidermal growth factor promoter and 5'-flanking region. Role for an atypical TATA sequence
    S E Fenton
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 271:30870-8. 1996
    ..toward delineating mechanisms that regulate its activity, we have characterized the mouse epidermal growth factor (EGF) promoter...
  77. ncbi Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit
    M Kashimata
    Department of Cell Biology and Anatomical Sciences, City University of New York Medical School, New York, New York 10031, USA
    Dev Dyn 208:149-61. 1997
    Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) regulate branching morphogenesis of fetal mouse submandibular gland (SMG) rudiments in vitro...
  78. pmc Effects of epidermal growth factor on preimplantation mouse embryos
    A Terada
    Department of Obstetrics and Gynecology, Mie University School of Medicine, Japan
    J Assist Reprod Genet 14:404-11. 1997
    Our purpose was to clarify the effects of epidermal growth factor (EGF) on mouse preimplantation embryos.
  79. ncbi Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    R J Wechsler-Reya
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Neuron 22:103-14. 1999
    ..Blocking Shh function in vivo dramatically reduces GCP proliferation. These findings provide insight into the mechanisms of normal growth and tumorigenesis in the cerebellum...
  80. ncbi Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations
    T Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California, 90089, USA
    Anat Rec 256:252-68. 1999
    ..We report here the protein expression in embryonic SMGs of four signal transduction pathways: TGF-alpha/EGF/EGF-R; IGF-II/IGF-IR/IGF-IIR; TGF-betas and cognate receptors; TNF, IL-6, and cognate receptors...
  81. ncbi Involvement of heparin-binding EGF-like growth factor and its processing by metalloproteinases in early epithelial morphogenesis of the submandibular gland
    Y Umeda
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka 560 0043, Japan
    Dev Biol 237:202-11. 2001
    In the present study, the role of a member of the epidermal growth factor (EGF) family, heparin-binding EGF-like growth factor (HB-EGF), in organ development was investigated by using developing mouse submandibular gland (SMG), in which ..
  82. ncbi Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes
    Fabienne Desmots
    INSERM U456, Faculte de Pharmacie, Universite de Rennes I, 35043 Rennes Cedex, France
    J Biol Chem 277:17892-900. 2002
    ..cultured hepatocytes by tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), and epidermal growth factor (EGF), factors that play crucial roles in hepatocyte survival and proliferation during liver regeneration...
  83. pmc Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain
    Hidenori Shiraha
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Cell Biol 22:2716-27. 2002
    ..protein 10, monokine induced by gamma interferon, and platelet factor 4 inhibit epidermal growth factor (EGF)-induced m-calpain activation and thereby EGF-induced fibroblast cell motility (H. Shiraha, A. Glading, K...
  84. ncbi Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor
    Yuji Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:23216-22. 2002
    ..It is a substrate for the insulin receptor as well as the epidermal growth factor (EGF) receptor and other receptor-tyrosine kinases...
  85. ncbi Growth factor engineering by degenerate homoduplex gene family recombination
    Wayne M Coco
    Enchira Biotechnology Corporation, 4200 Research Forest Drive, The Woodlands, TX 77381, USA
    Nat Biotechnol 20:1246-50. 2002
    ..of "top-strand" oligonucleotides incorporating polymorphisms from mammalian genes encoding epidermal growth factor (EGF) using multiple polymorphic "scaffold" oligonucleotides. Top strands were then linked by gap filling and ligation...
  86. ncbi Epidermal growth factor as a biologic switch in hair growth cycle
    Kingston K L Mak
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Biol Chem 278:26120-6. 2003
    ..We propose that epidermal growth factor functions as a biologic switch that is turned on and off in hair follicles at the beginning and end of the anagen phase of the hair cycle, guarding the entry to and exit from the anagen phase...
  87. ncbi Divergence of epidermal growth factor - transforming growth factor beta signaling in embryonic orofacial tissue
    Vasker Bhattacherjee
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville School of Dentistry, Louisville, Kentucky 40292, USA
    In Vitro Cell Dev Biol Anim 39:257-61. 2003
    The epidermal growth factor (EGF) and transforming growth factor beta (TGFbeta) families of signaling molecules play a major role in growth and development of embryos...
  88. ncbi Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer
    Christopher W Gregory
    Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 7500, USA
    J Biol Chem 279:7119-30. 2004
    ..In this report, we show that epidermal growth factor (EGF) increases androgen-dependent AR transactivation in the recurrent prostate cancer cell line CWR-R1 through a ..
  89. ncbi G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway
    Jacques T Weissman
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    Oncogene 23:241-9. 2004
    ..A constitutively active mutant of Galphai2 also mediated Ras/rap-dependent responses. These data indicate that GPCRs coupled to pertussis-toxin-sensitive G-proteins activate Rap through a Galpha subunit, C3G, and Src-dependent pathway...
  90. ncbi Immunohistochemical study of genesis of the mouse oral vestibule
    Shunji Kumabe
    Department of Oral Anatomy, Osaka Dental University, 8 1, Kuzuhahanazono cho, Hirakata shi, Osaka 573 1121, Japan
    Okajimas Folia Anat Jpn 80:93-102. 2003
    ..The following results were obtained: 1) EGF, TGFalpha, EGFR, PCNA, FGF2, pRb, and FGFR1-4 were immunolocalized in the developing tissues...
  91. ncbi Mechanotransduction through growth-factor shedding into the extracellular space
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 429:83-6. 2004
    ....
  92. ncbi The sequential cleavage of membrane anchored pro-EGF requires a membrane serine protease other than kallikrein in rat kidney
    Sylvain M Le Gall
    Institut de Biochimie et Biophysique Moléculaire et Cellulaire CNRS UMR 8619, Université Paris XI Bât 430, 91405 Orsay Cedex, France
    Regul Pept 122:119-29. 2004
    Epidermal growth factor (EGF) is present in kidney membranes as an integral type I precursor protein, enzymatically processed to release immunoreactive materials in urine or incubation medium...
  93. ncbi Suppressor of cytokine signalling-2 and epidermal growth factor regulate neurite outgrowth of cortical neurons
    Yona Goldshmit
    Neural Regeneration Laboratory, Centre for Neuroscience, The University of Melbourne, Parkville, Victoria 3010, Australia
    Eur J Neurosci 20:2260-6. 2004
    ..regulator of cytokine signalling, suppressor of cytokine signalling-2 (SOCS2) and epidermal growth factor (EGF), both of which are expressed in the cortical plate during neural development, promote neurite outgrowth of ..
  94. pmc Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling
    Sandra E Nicholson
    The Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 102:2328-33. 2005
    ..the ability of SOCS-5 to negatively regulate signaling cascades downstream of the epidermal growth factor receptor (EGF-R) has been examined by using an EGF-responsive cell line engineered to constitutively express the EGF-R and SOCS-5 ..
  95. ncbi Epidermal growth factor potentiates renal cell death in hydronephrotic neonatal mice, but cell survival in rats
    Susan C Kiley
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 68:504-14. 2005
    Epidermal growth factor (EGF) markedly attenuates tubular apoptosis induced by unilateral ureteral obstruction (UUO) in the neonatal rat, and reduces apoptosis induced by mechanical stretch of cultured rat tubular cells.
  96. pmc Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1
    Si Tse Jiang
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan
    Am J Pathol 168:205-20. 2006
    ..Abnormalities in Na(+)/K(+)-ATPase, aquaporin-2, and vasopressin V2 receptor expression were also identified. This mouse model may be suitable for further studies of progression and therapeutic interventions of ADPKD...
  97. ncbi The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation
    Elizabeth A Duncan
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 281:12521-5. 2006
    ..In this work, we have shown that MSK1/2 are required for epidermal growth factor (EGF)-induced, but not tumor necrosis factor-induced, histone H3-Ser10 phosphorylation, both globally and at specific ..
  98. ncbi Binding of epidermal growth factor and transforming growth factor-alpha in mammalian preimplantation embryos
    B Fischer
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Theriogenology 41:879-87. 1994
    ..of the pig (Days 11 to 15), cow (Days 14 to 16), sheep (Day 14) and pony (Day 16) bind epidermal growth factor (EGF) specifically. Binding was not detected in embryos of the rabbit at Day 5 or 6 or the hamster at Day 3...
  99. ncbi SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15
    Akiyoshi Uezu
    Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Biol Chem 282:26481-9. 2007
    ..SGIP1alpha was colocalized with Eps15 and the AP-2 complex. Upon epidermal growth factor (EGF) stimulation, SGIP1alpha was colocalized with EGF at the plasma membrane, indicating the localization of SGIP1alpha ..
  100. pmc EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF
    Shenghong Yang
    Department of Biochemistry, Boston University School of Medicine, 715 Albany St, Boston, Massachusetts 02118, USA
    Am J Physiol Lung Cell Mol Physiol 295:L143-51. 2008
    ..tropoelastin mRNA levels in lung fibroblasts through transactivation of the epidermal growth factor (EGF) receptor (EGFR)/Mek/Erk pathway, which is dependent on the NE-initiated release of soluble EGFR ligands...
  101. pmc Palmitoylation of the EGF receptor impairs signal transduction and abolishes high-affinity ligand binding
    Jennifer L Macdonald-Obermann
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8231, St Louis, Missouri 63110, USA
    Biochemistry 48:2505-13. 2009
    The intracellular juxtamembrane domain of the EGF receptor has been shown to be involved in the stimulation of the receptor's tyrosine kinase activity...

Research Grants4

  1. ERBB REGULATION OF BREAST DEVELOPMENT AND TUMORIGENESI
    David Lee; Fiscal Year: 2004
    ..Finally, his development of knockout mice lacking several EGFR ligands (amphiregulin (AR), TGF-alpha, EGF) individually or in combination established roles for ERBB signaling in mammary gland development and function...
  2. Lipid Rafts and Cell Function
    Linda Pike; Fiscal Year: 2006
    ..and, iv) the role of rafts in endocytosis and protein processing. [unreadable] [unreadable]..
  3. Lipid Rafts and EGF Receptor Function
    LINDA JOY PIKE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The EGF receptor is a plasma membrane tyrosine kinase that is involved in the control of cell growth...