Edn1

Summary

Gene Symbol: Edn1
Description: endothelin 1
Alias: ET-1, preproET, PPET1, endothelin-1, preproendothelin, preproendothelin-1
Species: mouse

Top Publications

  1. pmc Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS
    Toshiharu Yamashita
    Department of Regenerative Medicine, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8575, Japan
    Mol Cell Biol 28:1285-97. 2008
  2. doi Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude
    Amie K Lund
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, USA
    Hypertension 51:803-9. 2008
  3. doi Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion
    Justin W C Leung
    Department of Anatomy, The University of Hong Kong, HKSAR, China
    Brain Res 1266:121-9. 2009
  4. pmc An endothelin-1 switch specifies maxillomandibular identity
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:18806-11. 2008
  5. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
  6. ncbi A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
  7. pmc Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina
    Simon S F Cheung
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e26184. 2011
  8. pmc Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats
    Qiaoling Zhou
    Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People s Republic of China
    PLoS ONE 7:e47360. 2012
  9. pmc Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice
    H Yanagisawa
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    J Clin Invest 102:22-33. 1998
  10. pmc High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric oxide
    K L Sweazea
    College of Nursing and Health Innovation, Arizona State University, Tempe, AZ 85287 4501, USA
    Horm Metab Res 43:470-6. 2011

Research Grants

  1. Trypanosoma cruzi and AIDS: Role of the Adipocyte
    Herbert Tanowitz; Fiscal Year: 2007
  2. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2008
  3. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2008
  4. Differentiation in T.cruzi:an emerging AIDS pathogen
    Huan Huang; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications109 found, 100 shown here

  1. pmc Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS
    Toshiharu Yamashita
    Department of Regenerative Medicine, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8575, Japan
    Mol Cell Biol 28:1285-97. 2008
    ..The expression of endothelin 1 and platelet-derived growth factor beta was increased in the lung endothelial cells of NEPAS/HIF-3alpha-null ..
  2. doi Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude
    Amie K Lund
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, USA
    Hypertension 51:803-9. 2008
    ..Our studies establish the AHR KO mouse as a model in which modest decreases in PIO(2) lead to hypoxemia, increased plasma ET-1, and systemic hypertension without increased pulmonary prepro-ET-1 mRNA expression...
  3. doi Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion
    Justin W C Leung
    Department of Anatomy, The University of Hong Kong, HKSAR, China
    Brain Res 1266:121-9. 2009
    ....
  4. pmc An endothelin-1 switch specifies maxillomandibular identity
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:18806-11. 2008
    ..The endothelin-1 (Edn1)/endothelin receptor type-A (Ednra)-->Dlx5/6-->Hand2 signaling pathway is necessary for lower jaw formation...
  5. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
    ....
  6. ncbi A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
    ..Mice harboring a null mutation of the endothelin-1 gene (Edn1), which is expressed in the epithelial layer of the branchial arches and encodes for the endothelin-1 (ET-1) ..
  7. pmc Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina
    Simon S F Cheung
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e26184. 2011
    ..Thus, over-expression of endothelial ET-1 in TET-1 mice may contribute to increased glutamate-induced neurotoxicity on neuronal cells and water accumulation in inner retina leading to edema...
  8. pmc Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats
    Qiaoling Zhou
    Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People s Republic of China
    PLoS ONE 7:e47360. 2012
    ..Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes...
  9. pmc Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice
    H Yanagisawa
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    J Clin Invest 102:22-33. 1998
    ..This study demonstrates that ET-1/ETA-mediated signaling plays an essential role in a complex process of aortic arch patterning by affecting the postmigratory cardiac neural crest cell development...
  10. pmc High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric oxide
    K L Sweazea
    College of Nursing and Health Innovation, Arizona State University, Tempe, AZ 85287 4501, USA
    Horm Metab Res 43:470-6. 2011
    ..Therefore, oxidative stress and iNOS are involved in the attenuation of endothelin-1 mediated vasoconstriction observed in isolated mesenteric arteries from high fat fed rats...
  11. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
    ..Dlx5, Dlx6, and Hand2 genes in mesenchymal cells via inducing expression of their upstream activator, Endothelin1 (Edn1), within ectodermal cells...
  12. pmc Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice
    Kazuo Yamashiro
    Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK
    J Cereb Blood Flow Metab 30:1494-503. 2010
    ..Taken together, our data suggest that the endothelial dysfunction observed in MCA associated with hypercholesterolemia is prevented by cilostazol, an effect likely due to the increase in eNOS phosphorylation and, therefore, activity...
  13. pmc Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84. 2004
    ..These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart...
  14. ncbi Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
    Marcus Maurer
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 432:512-6. 2004
    ..These findings identify a new biological function for mast cells: promotion of homeostasis by limiting the toxicity associated with an endogenous mediator...
  15. pmc BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension
    M Talati
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 27232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 299:L363-73. 2010
    ..This is the first description of protein expression that distinguishes HPAH from IPAH in patients...
  16. doi Low blood pressure in endothelial cell-specific endothelin 1 knockout mice
    Yaz Y Kisanuki
    Departments of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Tex75390 8584, USA
    Hypertension 56:121-8. 2010
    ..Taken in conjunction with other lines of genetically altered mice, our results provide evidence for a paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor...
  17. pmc Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:2496-503. 2005
    On the basis of previous observations, endothelin 1 (ET-1) has been suggested as contributing to the pathogenesis of Chagasic cardiomyopathy...
  18. pmc Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis
    K Laghmani
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9003, USA
    J Clin Invest 107:1563-9. 2001
    ..In C57BL/6 mice, excess acid ingestion increased renal cortical preproET-1 mRNA expression 2.4-fold and decreased preproET-3 mRNA expression by 37%...
  19. pmc Blockade of endothelin-1 with a novel series of 1,3,6-trisubstituted-2-carboxy-quinol-4-ones controls infection-associated preterm birth
    Nicole S Olgun
    College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
    Am J Pathol 177:1929-35. 2010
    ..These findings may be of clinical significance, as there is currently no FDA-approved therapy for women presenting with threatened preterm delivery...
  20. pmc Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta
    James M Luther
    Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    Endocrinology 150:2229-36. 2009
    ..infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-type (WT), aldosterone synthase-deficient (AS(-/-)), and AS(-/-)..
  21. doi Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition
    Bambang Widyantoro
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circulation 121:2407-18. 2010
    ..The underlying mechanism, however, remains elusive. Here, we hypothesize that ET-1 might contribute to the accumulation of cardiac fibroblasts through an endothelial-to-mesenchymal transition in diabetic hearts...
  22. doi Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation
    Dyah W Anggrahini
    Division of Cardiovascular Medicine, Department of Internal Medicine, 7 5 1 Kusunoki, Chuo, Kobe 650 0017, Japan
    Cardiovasc Res 82:143-51. 2009
    ..In this study, we determined the role of vascular endothelial ET-1 on vascular inflammation and neointima formation using vascular endothelial ET-1-knockout [ET-1(f/f); Tie2-Cre (+)] mice...
  23. ncbi Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, Rome 00158, Italy
    J Biol Chem 278:41294-301. 2003
    ....
  24. ncbi Endothelin-1 expression in vascular adventitial fibroblasts
    Sheng Jun An
    Dept of Community Health Sciences, Faculty of Applied Health Sciences, Brock Univ, St Catharines, ON, Canada L2S 3Y6
    Am J Physiol Heart Circ Physiol 290:H700-8. 2006
    ..mRNA levels of preproET-1 and type I procollagen were detected with relative RT-PCR...
  25. ncbi Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment
    Pierre Sonveaux
    University of Louvain Medical School, Unit of Pharmacology and Therapeutics FATH 5349, Brussels, Belgium
    Cancer Res 64:3209-14. 2004
    ..Thus, blocking the tumor-selective increase in the vascular endothelin-1/ETA pathway led us to unravel an important reserve of vasorelaxation that can be exploited to selectively increase tumor response to radiotherapy...
  26. doi Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1
    N F Kelland
    Clinical Pharmacology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Can J Physiol Pharmacol 88:644-51. 2010
    ..These studies suggest that EC-ETB are largely responsible for the clearance of ET-1 from the circulation...
  27. doi Connexin43 is involved in the effect of endothelin-1 on astrocyte proliferation and glucose uptake
    Sandra Herrero-González
    Departamento de Bioquimica y Biologia Molecular, INCYL, Universidad de Salamanca, Spain
    Glia 57:222-33. 2009
    ..Interestingly, although the rate of growth in connexin43 KO astrocytes has been reported to be reduced, we observed that an acute reduction in connexin43 by siRNA increased proliferation and glucose uptake...
  28. ncbi Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice
    F Hasue
    Department of Autonomic Physiology, 1 8 1, Nohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
    Neuroscience 130:349-58. 2005
    ..The results of the present study suggest that neuronal ET-1 is involved in endogenous pain inhibitory control likely via pathways through the hypothalamus...
  29. ncbi Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism
    Deepa Bedi
    Boshell Diabetes and Metabolic Diseases Research Program, Department of Anatomy, Physiology and Pharmacology, Auburn University, USA
    Biochem Biophys Res Commun 345:332-9. 2006
    ..In conclusion, we demonstrate that ET-1 inhibits basal and insulin-stimulated adiponectin secretion through PIP(2) modulation of the actin cytoskeleton...
  30. pmc Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries
    Sergio de Frutos
    Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA
    Am J Physiol Cell Physiol 301:C441-50. 2011
    ..Here, we demonstrate that ROK increases actin polymerization, thus providing structural support for NFATc3 nuclear transport...
  31. ncbi Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme
    Kathryn Ivey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9104, USA
    Dev Biol 255:230-7. 2003
    ..We conclude that the Galpha(q) and Galpha(11) proteins serve as the intracellular mediators of ET-1 signaling in the pharyngeal arch mesenchyme...
  32. pmc Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells
    Lisa R Stow
    Department of Medicine, University of Florida, Gainesville, FL 32610, United States
    Steroids 77:360-6. 2012
    Aldosterone stimulates the endothelin-1 gene (Edn1) in renal collecting duct (CD) cells by a mechanism involving the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR)...
  33. pmc APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice
    Yi Wang
    Department of Medicine, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Diabetes 60:3044-54. 2011
    ..This study aimed to investigate the roles of the multidomain adaptor protein APPL1 in modulating vascular actions of insulin in mice and in endothelial cells...
  34. doi The inhibitory effect of miRNA-1 on ET-1 gene expression
    Dong Li
    Department of Physiology, Second Military Medical University, Shanghai 200433, China
    FEBS Lett 586:1014-21. 2012
    ..We further confirmed that miRNA-1 could inhibit endogenous ET-1 gene expression at the post-transcriptional level. Our study provides a new perspective on the regulatory mechanism of ET-1 gene...
  35. ncbi Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts
    H Tokuda
    Department of Internal Medicine, Chubu National Hospital, National Institute for Longevity Sciences, Obu, Aichi 474 8511, Japan
    Eur J Endocrinol 149:239-45. 2003
    ..In the present study, we have investigated the involvement of SAPK/JNK in ET-1-induced HSP27 in MC3T3-E1 cells...
  36. doi Endothelin-1 induces connective tissue growth factor expression in cardiomyocytes
    Anna Grazia Recchia
    Department of Pharmaco Biology, Cell Biology, University of Calabria, 87036 Rende CS, Italy
    J Mol Cell Cardiol 46:352-9. 2009
    ..CTGF inhibitors should be considered in setting a comprehensive pharmacological approach towards ET-1 induced cardiovascular diseases...
  37. doi Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection
    Victor K L Hung
    Department of Anaesthesiology, The University of Hong Kong, HKSAR, China
    Life Sci 91:618-22. 2012
    ..Therefore, the aim of this study is to determine the role of cell-type specific ET-1 induction in the modulation of inflammatory pain processing...
  38. ncbi Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence
    Huan Huang
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park, Bronx, New York, NY 10461, U S A
    Clin Sci (Lond) 103:263S-266S. 2002
    ..These data provide further support for a role for ET-1 in the pathogenesis of chronic chagasic heart disease, and indicate that cardiac myocytes are an important source of ET-1 in this disease...
  39. ncbi Increased gene expression of endothelin-1 and vasoactive intestinal contractor/endothelin-2 in the mammary gland of lactating mice
    Takaharu Kozakai
    Laboratory of Gene Function Analysis, Institute of Molecular and Cell Biology, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, 305 8566, Ibaraki, Japan
    Biochem Biophys Res Commun 297:1339-43. 2002
    ..The observed increase in ET-1 expression in differentiated epithelial cells suggests physiological roles for ET-1, including milk production and secretion in the mammary gland of lactating mice...
  40. pmc Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    A Trumpp
    G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
    Genes Dev 13:3136-48. 1999
    ..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
  41. doi Lack of iNOS impairs endothelial function in endothelin-1 transgenic mice
    Thomas Quaschning
    Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
    Kidney Blood Press Res 31:127-34. 2008
    ....
  42. ncbi Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells
    A Yogi
    Kidney Research Centre, University of Ottawa Ottawa Health Research Institute, 451 Smyth Rd, Ottawa, ON, KIH 8M5
    Arterioscler Thromb Vasc Biol 27:1960-7. 2007
    ..Here we sought to determine whether upstream regulators of mitogen-activated protein kinases (MAPKs) are differentially regulated by ET-1 and Ang II focusing on the role of c-Src and the small GTPase Ras...
  43. doi Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: tight skin mice 1
    Vincent Richard
    Inserm U644 and Rouen University Hospital, Institute for Biomedical Research and IFRMP 23, University of Rouen, Rouen, France
    Fundam Clin Pharmacol 22:649-55. 2008
    ..The ET antagonist bosentan prevents endothelial alterations, suggesting a major role of ET in the adverse vascular effects of SSc...
  44. doi Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications
    Jane Chiu
    Department of Pathology, 4033 Dental Sciences Building, University of Western Ontario, 1151 Richmond Street North, London, ON N6A5C1, Canada
    Can J Physiol Pharmacol 86:365-72. 2008
    ..Hence, blockade of such pathways may constitute potential adjuvant treatment modalities in chronic diabetic complications...
  45. doi Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1
    Fernando de Paiva Conte
    Departamento de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Leukoc Biol 84:652-60. 2008
    ..These findings suggest that endogenous ETs contribute to knee-joint inflammation, acting through ET(A) and ET(B) receptors and modulating edema formation, neutrophil recruitment, and production of inflammatory mediators...
  46. ncbi Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin II
    Weihua Ni
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Circ Res 101:985-94. 2007
    ..In summary, Ets-1 functions as a critical downstream transcriptional mediator of Ang II ROS generation by regulating the expression of NAD(P)H oxidase subunits such as p47(phox)...
  47. ncbi Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes
    S B Bender
    Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, Ohio 45701, USA
    Am J Physiol Heart Circ Physiol 293:H2281-8. 2007
    ..Therefore, in this model, enhanced coronary ET-1 responsiveness is mediated primarily through smooth muscle ET(B) receptors, whereas the interaction with alpha(1)-ARs is mediated solely through the ET(A) receptor subtype...
  48. doi Paracrine regulation of the resumption of oocyte meiosis by endothelin-1
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543, Japan
    Dev Biol 327:62-70. 2009
    ....
  49. ncbi Endogenous endothelin-1 is required for cardiomyocyte survival in vivo
    Xiao Song Zhao
    Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Circulation 114:830-7. 2006
    ..To investigate the role of ET-1 in the heart, we created mice with cardiomyocyte deletion of ET-1...
  50. ncbi Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice
    Hironori Yuyama
    Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Cardiovasc Pharmacol 44:S479-82. 2004
    ..These results suggest that selective endothelin-A receptor antagonists relieve pain in patients with various diseases in which ET-1 production increases (e.g. prostate cancer)...
  51. ncbi Endothelin-1 protects astrocytes from hypoxic/ischemic injury
    M C Ho
    Institute of Molecular Biology, The University of Hong Kong, Pokfulam
    FASEB J 15:618-26. 2001
    ..The present study suggests that astrocytes without ET-1 are more vulnerable to H and H/I injuries and that the up-regulation of astrocytic ET-1 is essential for the survival of astrocytes...
  52. pmc Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Immunol 186:6024-34. 2011
    ..In this study, we found that IgG from women with PE, in contrast to IgG from normotensive pregnant women, induced preproET-1 mRNA expression via angiotensin II type 1 receptor activation in kidneys and placentas in pregnant mice...
  53. ncbi Identification of an endothelial cell-specific regulatory region in the murine endothelin-1 gene
    X Bu
    Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 272:32613-22. 1997
    ..The combination of all three elements promotes binding of a protein complex that is endothelial cell-specific. This is the first evidence for an endothelial cell-specific DNA regulatory element and cognate binding proteins...
  54. ncbi Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Am J Physiol 270:R1279-86. 1996
    ..Our results demonstrate that ventilatory responses to hypoxia and hypercapnia are impaired in ET-1-deficient mice and suggest that endogenous ET-1 participates in the physiological control of ventilation...
  55. ncbi Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development
    T S Chan
    Institute of Molecular Biology, University of Hong Kong
    Eur J Biochem 234:819-26. 1995
    ..These data will be useful for analyzing the function of ET-1 in these organs...
  56. ncbi Renal sympathetic nerve activity in mice: comparison between mice and rats and between normal and endothelin-1 deficient mice
    G Y Ling
    Department of Physiology, School of Medicine, Chiba University, Chiba 260 8670, Japan
    Brain Res 808:238-49. 1998
    ..Baroreceptor resetting and normally preserved hypoxia-induced chemoreflex may explain a part of the elevation of AP in ET-1 deficient mice...
  57. pmc Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention
    Dowhan Ahn
    Division of Nephrology, University of Utah Health Sciences Center, 1900 East 30 North, Salt Lake City, UT 84132, USA
    J Clin Invest 114:504-11. 2004
    ..These studies indicate that CD-derived ET-1 is an important physiologic regulator of renal Na excretion and systemic BP...
  58. ncbi Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase
    Martin Weinzierl
    Department of Neurological Surgery, RWTH Aachen, Germany
    Brain Res 1030:125-32. 2004
    ..Together, these findings suggest that ET-1 mediates oxidative stress in the spinal cord through the modulation of spinal cord blood flow...
  59. doi Vascular inflammation in absence of blood pressure elevation in transgenic murine model overexpressing endothelin-1 in endothelial cells
    Farhad Amiri
    Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Hypertens 26:1102-9. 2008
    We previously showed that in transgenic mice with endothelium-targeted overexpression of human preproendothelin-1, mesenteric resistance arteries exhibited vascular remodeling, endothelial dysfunction and increased oxidative stress early ..
  60. ncbi Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality
    Yuqiang Ge
    Division of Nephrology, University of Utah Health Sciences Center, 30 North 1900 East, Salt Lake City, Utah 84132, USA
    Am J Physiol Renal Physiol 288:F912-20. 2005
    ..These data indicate that CD ET-1 KO increases renal sensitivity to the urinary concentrating effects of AVP and suggest that ET-1 functions as a physiological autocrine regulator of AVP action in the CD...
  61. pmc Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1
    Y Kurihara
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Clin Invest 96:293-300. 1995
    ..To clarify the physiological and pathophysiological role of ET-1, we disrupted the mouse Edn1 locus encoding ET-1 by gene targeting and demonstrated that ET-1 is essential to the normal development of ..
  62. ncbi Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusion
    Justin W C Leung
    Institute of Molecular Biology, The University of Hong Kong, Hong Kong SAR, China
    J Cardiovasc Pharmacol 44:S293-300. 2004
    ..Our present TET model will serve as an ideal model for studying the role of endothelial ET- 1 in the pathogenesis of ischemic stroke...
  63. ncbi Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice
    T Nagase
    Department of Geriatric Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Appl Physiol (1985) 87:2020-4. 1999
    ..Recently, it has been reported that ET-1 and a gene encoding ET-1 (Edn1) might be involved in airway hyperresponsiveness, which is a major feature of bronchial asthma...
  64. pmc Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice
    Ben Fogelgren
    Deptartment of Anatomy, Biochemistry, and Physiology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    Am J Physiol Renal Physiol 296:F1166-78. 2009
    ..Defects are associated with embryological deficiencies of Six2, suggesting that proper levels of this protein during nephrogenesis are critical for normal glomerular development and adult renal function...
  65. pmc Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway
    Fernanda R C Giachini
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Am J Physiol Heart Circ Physiol 296:H489-96. 2009
    ..These data demonstrate that IL-10 counteracts ET(A)-mediated vascular responses to ET-1, as well as activation of the ERK1/2 pathway...
  66. doi Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice
    Barbara Baragatti
    Scuola Superiore Sant Anna, Piazza Martiri della Libertà 33, Pisa 56127, Italy
    Am J Physiol Heart Circ Physiol 300:H892-901. 2011
    ....
  67. pmc ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling
    Hiba Komati
    Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Biol Chem 286:1508-16. 2011
    ..Together, the results identify a novel nuclear effector of ET-1 signaling and suggest that PEX1 may be a regulator of the early stages of cardiac hypertrophy...
  68. doi Endothelin-1 and angiotensin II modulate rate and contraction amplitude in a subpopulation of mouse embryonic stem cell-derived cardiomyocyte-containing bodies
    E L Lagerqvist
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, Melbourne, Australia
    Stem Cell Res 6:23-33. 2011
    ..These results indicate the presence of functional ET(A) and both AT₁ and AT₂ receptors in murine ESC-CMs, but their expression and or activity appears to be evident only in a limited set of BBs...
  69. ncbi Development of the vertebrate ear: insights from knockouts and mutants
    D M Fekete
    Dept of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Trends Neurosci 22:263-9. 1999
    ..Genes that are regionally expressed in the inner ear can, when absent or mutated, yield selective ablation of specific inner-ear structures or cell types...
  70. doi Endothelin axis induces metalloproteinase activation and invasiveness in human lymphatic endothelial cells
    Francesca Spinella
    Molecular Pathology Laboratory, Regina Elena Cancer Institute, 00144 Rome, Italy
    Can J Physiol Pharmacol 88:782-7. 2010
    ..Our results suggest that ET-1 is a lymphangiogenic mediator and that targeting pharmacologically ETB may be therapeutically exploited in a variety of diseases, including cancer...
  71. ncbi Endothelin-1 aggravates hepatic ischemia/reperfusion injury during obstructive cholestasis in bile duct ligated mice
    Hiroyuki Nagai
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Surg Res 162:46-53. 2010
    ..However, the mechanism of liver injury in cholestatic liver is not fully understood. The goal of this study was to investigate the process of liver injury due to hepatic ischemia/reperfusion in obstructive cholestasis...
  72. pmc Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis
    Yuqing Chen
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0838, USA
    J Am Soc Nephrol 20:1623-32. 2009
    ..In patients with progressive hypertensive renal disease, a CHGA haplotype predicted rate of GFR decline. In conclusion, these data suggest that CHGA acts through the glomerular endothelium to regulate renal function...
  73. doi Effect of endothelin-1 on osteoblastic differentiation is modified by the level of connexin43: comparative study on calvarial osteoblastic cells isolated from Cx43+/- and Cx43+/+ mice
    Graziello Geneau
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, CNRS UMR 6187, 86022, Poitiers Cedex, France
    Cell Tissue Res 340:103-15. 2010
    ..With respect to roles in mechanotransduction and OB differentiation, Cx43 might modulate osteoblastic sensitivity to soluble factors...
  74. doi Expression and localization of endothelin-1 and its receptors in the spiral ganglion neurons of mouse
    Tao Liu
    Department of Otorhinolaryngology, West China Hospital of Sichuan University, No 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, People s Republic of China
    Cell Mol Neurobiol 29:739-45. 2009
    ..The present results suggest that ET-1 may play physiological roles in the spiral ganglion cells via ETAR and ETBR...
  75. pmc Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter
    D Harats
    Syntex Discovery Research, Palo Alto, California 94303
    J Clin Invest 95:1335-44. 1995
    ..genes in the vascular wall, we created transgenic mice using the reporter gene luciferase and the murine preproendothelin-1 promoter...
  76. ncbi Endothelin-1 regulates the dorsoventral branchial arch patterning in mice
    Hidenori Ozeki
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mech Dev 121:387-95. 2004
    ..These findings indicate that the ET-1/EdnrA signaling may contribute to the dorsoventral axis patterning of the branchial arch system as a mediator of the regional intercellular interactions...
  77. ncbi Development gone awry: congenital heart disease
    Peter J Gruber
    Cardiac Center, Children s Hospital of Philadelphia, PA, USA
    Circ Res 94:273-83. 2004
    ..In this review, we summarize some of the more clinically significant forms of congenital heart disease, and we highlight relevant genetic and developmental pathways...
  78. ncbi Thapsigargin and EGTA inhibit endothelin-1-induced glucose transport
    Ying Shun Kao
    Institute of Biochemistry, National Yang Ming University, Taipei, Taiwan ROC
    J Biomed Sci 11:206-13. 2004
    ....
  79. ncbi Endothelin-1-stimulated glucose uptake is desensitized by tumor necrosis factor-alpha in 3T3-L1 adipocytes
    Nadia Rachdaoui
    Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Physiol Endocrinol Metab 285:E545-51. 2003
    ....
  80. ncbi The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome
    Lazaros Kochilas
    Cardiovascular Division, University of Pennsylvania, Philadelphia 19104, USA
    Dev Biol 251:157-66. 2002
    ..Based on our studies, we propose that Lgdel genes are required for the expression of soluble signals that regulate neural crest cell differentiation...
  81. ncbi Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin-2 gene (EDN2): comparison with the endothelin-1 gene (EDN1)
    Kaname Saida
    National Institute of Advanced Industrial Science and Technology, Ministry of Economy, Trade and Industry, Tsukuba, Ibaraki 305 8566, Japan
    Clin Sci (Lond) 103:84S-89S. 2002
    ..Similarities between the genomic organization of the PPVIC/preproET2 and preproendothelin-1 genes suggest that the two are distantly related...
  82. ncbi The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression
    K Saida
    National Institute of Bioscience and Human Technology, Tsukuba, Ibaraki, 305 8566, Japan
    Genomics 64:51-61. 2000
    ..Several remarkable similarities of the PPVIC gene to the human preproendothelin-1 gene strongly suggest that the two genes have arisen from a common progenitor by gene duplication...
  83. ncbi Endothelin in the central control of cardiovascular and respiratory functions
    T Kuwaki
    Department of Physiology, School of Medicine, Chiba University, Japan
    Clin Exp Pharmacol Physiol 26:989-94. 1999
    ..6. We conclude that endogenous ET-1 plays an important role in the central neural control of circulation and respiration and that ETA receptors mediate this mechanism...
  84. ncbi Analysis of the desmoplakin gene reveals striking conservation with other members of the plakin family of cytolinkers
    K J Green
    Department of Pathology, R H Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Exp Dermatol 8:462-70. 1999
    ..Detailed characterization and mapping of these genes will facilitate their further evaluation as targets of genetic disorders and provide insights into the evolutionary relationships among molecules in this emerging gene family...
  85. ncbi Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles
    G E Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 213:418-31. 1999
    ..Implications for the development of human congenital heart defects are discussed...
  86. ncbi Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice
    H Morita
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Hypertens Res 22:11-6. 1999
    ..Mice heterozygous for the null mutation of the endothelin-1 (ET-1) gene, Edn1, may be a potential tool for studying this mechanism, because they have elevated blood pressure and disturbances in ..
  87. pmc Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice
    M Barton
    Cardiology, University Hospital Zürich and Cardiovascular Research Laboratory, Institute of Physiology, University of Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 95:14367-72. 1998
    ..ETA receptor blockade may have therapeutic potential in patients with atherosclerosis...
  88. ncbi Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice
    K Maemura
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Cardiovasc Pharmacol 26:S17-21. 1995
    ..ET-1 mRNA and peptide levels were in parallel with the number of Edn1 authentic alleles...
  89. ncbi Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice
    T Nakamura
    Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 4:1064-72. 1993
    ..1-fold at 1 wk, 4.2-fold at 2 wk, and 6.2-fold at 3 wk; TNF-alpha, 2.2-fold at 1 wk, 3.8-fold at 2 wk, and 5.4-fold at 3 wk).(ABSTRACT TRUNCATED AT 250 WORDS)..
  90. ncbi Synergistic effect of endothelin-1 and cyclic AMP on glucose transport in 3T3-L1 adipocytes
    Jim C Fong
    Institute of Biochemistry, National Yang Ming University, 155, Sec 2, Linung Street, 112 Taipei, Taiwan
    Cell Signal 16:811-21. 2004
    ..Taken together, these results indicate that ET-1 may act with cAMP in a synergistic way to increase glucose transport, probably through enhanced GLUT1 expression via a PKC-dependent mechanism...
  91. ncbi Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure
    Yuqiang Ge
    Division of Nephrology, Univ of Utah Health Sciences Center, 1900 East, 30 North, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 289:F692-8. 2005
    ..Furthermore, the CD ET(A) receptor does not appear to be involved in modulation of systemic blood pressure or renal Na excretion under physiological conditions...
  92. ncbi Expression of a neuropeptide, endothelin-1 in pons and medulla of prenatal and perinatal mouse brains
    Margaret C S Tsang
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    Int J Neurosci 115:1485-501. 2005
    ..This article demonstrates the spatio-temporal expression of mouse preproendothelin-1 (mPPET-1) gene in pre- and perinatal mouse brain by in situ hybridization using a probe specific for mPPET-..
  93. pmc Mouse model of focal cerebral ischemia using endothelin-1
    Nobutaka Horie
    Department of Neurosurgery, Stanford School of Medicine, Stanford, CA 94305 5487, USA
    J Neurosci Methods 173:286-90. 2008
    ..However, lesion size was still relatively small and strain-dependent. This study shows that ET-1 has a much less potent effect for producing an infarct in mice than rats...
  94. doi Role of the renin-angiotensin-aldosterone system in collecting duct-derived endothelin-1 regulation of blood pressure
    Yuqiang Ge
    Division of Nephrology, University of Utah Health Sciences Center, 1900 East 30 North, Salt Lake City, UT 84132, USA
    Can J Physiol Pharmacol 86:329-36. 2008
    ..In summary, hypertension in CD ET-1 KO is partly due to angiotensin II and aldosterone. We speculate that CD-derived ET-1 may regulate, via a novel pathway, renal renin production...
  95. pmc Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
    Takako Makita
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 452:759-63. 2008
    ..Moreover, they suggest a model in which newborn sympathetic neurons distinguish and choose between distinct vascular trajectories to innervate their appropriate end organs...
  96. pmc Blockade of endothelinergic receptors prevents development of proliferative vitreoretinopathy in mice
    María Iribarne
    Facultad de Ciencias Biomedicas, Universidad Austral, Pilar, Buenos Aires, Argentina
    Am J Pathol 172:1030-42. 2008
    ..In addition, the presence of ET-1 and ETR-B in human fibrous membranes suggests that similar treatments could be helpful after PVR has been established...
  97. ncbi Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene
    Sabine Stuebe
    Universitäres Herzzentrum, Kardiologie, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 376:363-73. 2008
    ..This activation is mediated by heterotrimeric G proteins, Rho GTPases, and is under negative control of the transcription factor YY1...
  98. ncbi Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts
    Haruhiko Tokuda
    Department of Clinical Laboratory, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8511, and Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 362:799-804. 2007
    ..These results strongly suggest that Rho-kinase regulates ET-1-stimulated IL-6 synthesis through p38 MAP kinase activation in osteoblasts...
  99. ncbi Endothelin-1 regulates adiponectin gene expression and secretion in 3T3-L1 adipocytes via distinct signaling pathways
    Chi Chang Juan
    Department of Physiology, School of Medicine, National Yang Ming University, and Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
    Endocrinology 148:1835-42. 2007
    ..These findings suggested that the cardiovascular system affects adipocyte physiology by regulating the expression of adipocytokines and, consequently, energy homeostasis via vasoactive factors, such as ET-1...
  100. ncbi Obesity-induced upregulation of myocardial endothelin-1 expression is mediated by leptin
    Suko Adiarto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 353:623-7. 2007
    ..In contrast, in leptin-deficient obese (ob/ob) mice, both serum and myocardial ET-1 levels were not higher than in wild type mice. These findings suggest that upregulation of myocardial ET-1 by obesity is mediated by leptin...
  101. ncbi Endothelin-1, an ulcer inducer, promotes gastric ulcer healing via mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors
    Tsutomu Nishida
    Department of Gastroenterology and Hepatology, Clinical Research Bldg K1, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Am J Physiol Gastrointest Liver Physiol 290:G1041-50. 2006
    ..Thus ET-1 has important roles not only in ulcer formation but also in ulcer healing via mobilizing myofibroblasts and inducing production of stroma-derived factors...

Research Grants4

  1. Trypanosoma cruzi and AIDS: Role of the Adipocyte
    Herbert Tanowitz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  4. Differentiation in T.cruzi:an emerging AIDS pathogen
    Huan Huang; Fiscal Year: 2009
    ..To further delineate the components of this pathway, we will identify the TcPKA downstream interacting molecules, using both yeast two-hybrid assays and proteomic approaches. ..