Edn1

Summary

Gene Symbol: Edn1
Description: endothelin 1
Alias: ET-1, PPET1, preproET, endothelin-1, preproendothelin-1
Species: mouse

Top Publications

  1. doi Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude
    Amie K Lund
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, USA
    Hypertension 51:803-9. 2008
  2. doi Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion
    Justin W C Leung
    Department of Anatomy, The University of Hong Kong, HKSAR, China
    Brain Res 1266:121-9. 2009
  3. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
  4. ncbi A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
  5. pmc Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice
    Kazuo Yamashiro
    Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK
    J Cereb Blood Flow Metab 30:1494-503. 2010
  6. pmc High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric oxide
    K L Sweazea
    College of Nursing and Health Innovation, Arizona State University, Tempe, AZ 85287 4501, USA
    Horm Metab Res 43:470-6. 2011
  7. pmc Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina
    Simon S F Cheung
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e26184. 2011
  8. ncbi Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
    Marcus Maurer
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 432:512-6. 2004
  9. pmc Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:2496-503. 2005
  10. pmc BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension
    M Talati
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 27232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 299:L363-73. 2010

Research Grants

  1. REGULATION OF HUMAN GAMMA AND BETA GLOBIN GENES
    Joyce Lloyd; Fiscal Year: 2003
  2. Role of KLF2 in erythropoiesis and globin expression
    Joyce A Lloyd; Fiscal Year: 2010
  3. Trypanosoma cruzi and AIDS: Role of the Adipocyte
    Herbert Tanowitz; Fiscal Year: 2007
  4. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2008
  5. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2008
  6. Differentiation in T.cruzi:an emerging AIDS pathogen
    Huan Huang; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications139 found, 100 shown here

  1. doi Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude
    Amie K Lund
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, USA
    Hypertension 51:803-9. 2008
    ..Our studies establish the AHR KO mouse as a model in which modest decreases in PIO(2) lead to hypoxemia, increased plasma ET-1, and systemic hypertension without increased pulmonary prepro-ET-1 mRNA expression...
  2. doi Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion
    Justin W C Leung
    Department of Anatomy, The University of Hong Kong, HKSAR, China
    Brain Res 1266:121-9. 2009
    ....
  3. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
    ....
  4. ncbi A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
    ..Mice harboring a null mutation of the endothelin-1 gene (Edn1), which is expressed in the epithelial layer of the branchial arches and encodes for the endothelin-1 (ET-1) ..
  5. pmc Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice
    Kazuo Yamashiro
    Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK
    J Cereb Blood Flow Metab 30:1494-503. 2010
    ..Taken together, our data suggest that the endothelial dysfunction observed in MCA associated with hypercholesterolemia is prevented by cilostazol, an effect likely due to the increase in eNOS phosphorylation and, therefore, activity...
  6. pmc High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric oxide
    K L Sweazea
    College of Nursing and Health Innovation, Arizona State University, Tempe, AZ 85287 4501, USA
    Horm Metab Res 43:470-6. 2011
    ..Therefore, oxidative stress and iNOS are involved in the attenuation of endothelin-1 mediated vasoconstriction observed in isolated mesenteric arteries from high fat fed rats...
  7. pmc Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina
    Simon S F Cheung
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e26184. 2011
    ..Thus, over-expression of endothelial ET-1 in TET-1 mice may contribute to increased glutamate-induced neurotoxicity on neuronal cells and water accumulation in inner retina leading to edema...
  8. ncbi Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
    Marcus Maurer
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 432:512-6. 2004
    ..These findings identify a new biological function for mast cells: promotion of homeostasis by limiting the toxicity associated with an endogenous mediator...
  9. pmc Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:2496-503. 2005
    On the basis of previous observations, endothelin 1 (ET-1) has been suggested as contributing to the pathogenesis of Chagasic cardiomyopathy...
  10. pmc BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension
    M Talati
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 27232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 299:L363-73. 2010
    ..This is the first description of protein expression that distinguishes HPAH from IPAH in patients...
  11. pmc Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis
    K Laghmani
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9003, USA
    J Clin Invest 107:1563-9. 2001
    ..In C57BL/6 mice, excess acid ingestion increased renal cortical preproET-1 mRNA expression 2.4-fold and decreased preproET-3 mRNA expression by 37%...
  12. pmc Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta
    James M Luther
    Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    Endocrinology 150:2229-36. 2009
    ..Endogenous aldosterone contributes to the acute stimulatory effect of Ang II on PAI-1 and ppET-1 mRNA expression in the heart; renin activity correlates with basal profibrotic gene expression in the kidney...
  13. pmc Blockade of endothelin-1 with a novel series of 1,3,6-trisubstituted-2-carboxy-quinol-4-ones controls infection-associated preterm birth
    Nicole S Olgun
    College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
    Am J Pathol 177:1929-35. 2010
    ..These findings may be of clinical significance, as there is currently no FDA-approved therapy for women presenting with threatened preterm delivery...
  14. ncbi Increased gene expression of endothelin-1 and vasoactive intestinal contractor/endothelin-2 in the mammary gland of lactating mice
    Takaharu Kozakai
    Laboratory of Gene Function Analysis, Institute of Molecular and Cell Biology, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, 305 8566, Ibaraki, Japan
    Biochem Biophys Res Commun 297:1339-43. 2002
    ..The observed increase in ET-1 expression in differentiated epithelial cells suggests physiological roles for ET-1, including milk production and secretion in the mammary gland of lactating mice...
  15. ncbi Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme
    Kathryn Ivey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9104, USA
    Dev Biol 255:230-7. 2003
    ..We conclude that the Galpha(q) and Galpha(11) proteins serve as the intracellular mediators of ET-1 signaling in the pharyngeal arch mesenchyme...
  16. ncbi Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, Rome 00158, Italy
    J Biol Chem 278:41294-301. 2003
    ....
  17. ncbi Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts
    H Tokuda
    Department of Internal Medicine, Chubu National Hospital, National Institute for Longevity Sciences, Obu, Aichi 474 8511, Japan
    Eur J Endocrinol 149:239-45. 2003
    ..In the present study, we have investigated the involvement of SAPK/JNK in ET-1-induced HSP27 in MC3T3-E1 cells...
  18. ncbi Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment
    Pierre Sonveaux
    University of Louvain Medical School, Unit of Pharmacology and Therapeutics FATH 5349, Brussels, Belgium
    Cancer Res 64:3209-14. 2004
    ..Thus, blocking the tumor-selective increase in the vascular endothelin-1/ETA pathway led us to unravel an important reserve of vasorelaxation that can be exploited to selectively increase tumor response to radiotherapy...
  19. ncbi Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism
    Deepa Bedi
    Boshell Diabetes and Metabolic Diseases Research Program, Department of Anatomy, Physiology and Pharmacology, Auburn University, USA
    Biochem Biophys Res Commun 345:332-9. 2006
    ..In conclusion, we demonstrate that ET-1 inhibits basal and insulin-stimulated adiponectin secretion through PIP(2) modulation of the actin cytoskeleton...
  20. doi Endothelin-1 induces connective tissue growth factor expression in cardiomyocytes
    Anna Grazia Recchia
    Department of Pharmaco Biology, Cell Biology, University of Calabria, 87036 Rende CS, Italy
    J Mol Cell Cardiol 46:352-9. 2009
    ..CTGF inhibitors should be considered in setting a comprehensive pharmacological approach towards ET-1 induced cardiovascular diseases...
  21. pmc Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells
    Lisa R Stow
    Department of Medicine, University of Florida, Gainesville, FL 32610, United States
    Steroids 77:360-6. 2012
    Aldosterone stimulates the endothelin-1 gene (Edn1) in renal collecting duct (CD) cells by a mechanism involving the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR)...
  22. doi The inhibitory effect of miRNA-1 on ET-1 gene expression
    Dong Li
    Department of Physiology, Second Military Medical University, Shanghai 200433, China
    FEBS Lett 586:1014-21. 2012
    ..We further confirmed that miRNA-1 could inhibit endogenous ET-1 gene expression at the post-transcriptional level. Our study provides a new perspective on the regulatory mechanism of ET-1 gene...
  23. doi Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection
    Victor K L Hung
    Department of Anaesthesiology, The University of Hong Kong, HKSAR, China
    Life Sci 91:618-22. 2012
    ..Therefore, the aim of this study is to determine the role of cell-type specific ET-1 induction in the modulation of inflammatory pain processing...
  24. ncbi Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells
    A Yogi
    Kidney Research Centre, University of Ottawa Ottawa Health Research Institute, 451 Smyth Rd, Ottawa, ON, KIH 8M5
    Arterioscler Thromb Vasc Biol 27:1960-7. 2007
    ..Here we sought to determine whether upstream regulators of mitogen-activated protein kinases (MAPKs) are differentially regulated by ET-1 and Ang II focusing on the role of c-Src and the small GTPase Ras...
  25. doi Lack of iNOS impairs endothelial function in endothelin-1 transgenic mice
    Thomas Quaschning
    Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
    Kidney Blood Press Res 31:127-34. 2008
    ....
  26. ncbi Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development
    T S Chan
    Institute of Molecular Biology, University of Hong Kong
    Eur J Biochem 234:819-26. 1995
    ..These data will be useful for analyzing the function of ET-1 in these organs...
  27. ncbi Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Am J Physiol 270:R1279-86. 1996
    ..Our results demonstrate that ventilatory responses to hypoxia and hypercapnia are impaired in ET-1-deficient mice and suggest that endogenous ET-1 participates in the physiological control of ventilation...
  28. ncbi Identification of an endothelial cell-specific regulatory region in the murine endothelin-1 gene
    X Bu
    Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 272:32613-22. 1997
    ..The combination of all three elements promotes binding of a protein complex that is endothelial cell-specific. This is the first evidence for an endothelial cell-specific DNA regulatory element and cognate binding proteins...
  29. ncbi Renal sympathetic nerve activity in mice: comparison between mice and rats and between normal and endothelin-1 deficient mice
    G Y Ling
    Department of Physiology, School of Medicine, Chiba University, Chiba 260 8670, Japan
    Brain Res 808:238-49. 1998
    ..Baroreceptor resetting and normally preserved hypoxia-induced chemoreflex may explain a part of the elevation of AP in ET-1 deficient mice...
  30. ncbi Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice
    T Nagase
    Department of Geriatric Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Appl Physiol (1985) 87:2020-4. 1999
    ..Recently, it has been reported that ET-1 and a gene encoding ET-1 (Edn1) might be involved in airway hyperresponsiveness, which is a major feature of bronchial asthma...
  31. ncbi Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase
    Martin Weinzierl
    Department of Neurological Surgery, RWTH Aachen, Germany
    Brain Res 1030:125-32. 2004
    ..Together, these findings suggest that ET-1 mediates oxidative stress in the spinal cord through the modulation of spinal cord blood flow...
  32. ncbi Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice
    Hironori Yuyama
    Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Cardiovasc Pharmacol 44:S479-82. 2004
    ..These results suggest that selective endothelin-A receptor antagonists relieve pain in patients with various diseases in which ET-1 production increases (e.g. prostate cancer)...
  33. ncbi Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes
    S B Bender
    Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, Ohio 45701, USA
    Am J Physiol Heart Circ Physiol 293:H2281-8. 2007
    ..Therefore, in this model, enhanced coronary ET-1 responsiveness is mediated primarily through smooth muscle ET(B) receptors, whereas the interaction with alpha(1)-ARs is mediated solely through the ET(A) receptor subtype...
  34. doi Vascular inflammation in absence of blood pressure elevation in transgenic murine model overexpressing endothelin-1 in endothelial cells
    Farhad Amiri
    Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Hypertens 26:1102-9. 2008
    ..To further characterize this model, the role of vascular inflammation was investigated in young male transgenic and wild-type littermate mice...
  35. doi Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1
    Fernando de Paiva Conte
    Departamento de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Leukoc Biol 84:652-60. 2008
    ..These findings suggest that endogenous ETs contribute to knee-joint inflammation, acting through ET(A) and ET(B) receptors and modulating edema formation, neutrophil recruitment, and production of inflammatory mediators...
  36. doi Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications
    Jane Chiu
    Department of Pathology, 4033 Dental Sciences Building, University of Western Ontario, 1151 Richmond Street North, London, ON N6A5C1, Canada
    Can J Physiol Pharmacol 86:365-72. 2008
    ..Hence, blockade of such pathways may constitute potential adjuvant treatment modalities in chronic diabetic complications...
  37. doi Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: tight skin mice 1
    Vincent Richard
    Inserm U644 and Rouen University Hospital, Institute for Biomedical Research and IFRMP 23, University of Rouen, Rouen, France
    Fundam Clin Pharmacol 22:649-55. 2008
    ..The ET antagonist bosentan prevents endothelial alterations, suggesting a major role of ET in the adverse vascular effects of SSc...
  38. doi Paracrine regulation of the resumption of oocyte meiosis by endothelin-1
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543, Japan
    Dev Biol 327:62-70. 2009
    ....
  39. pmc Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Immunol 186:6024-34. 2011
    ..In this study, we found that IgG from women with PE, in contrast to IgG from normotensive pregnant women, induced preproET-1 mRNA expression via angiotensin II type 1 receptor activation in kidneys and placentas in pregnant mice...
  40. pmc Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1
    Y Kurihara
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Clin Invest 96:293-300. 1995
    ..To clarify the physiological and pathophysiological role of ET-1, we disrupted the mouse Edn1 locus encoding ET-1 by gene targeting and demonstrated that ET-1 is essential to the normal development of ..
  41. ncbi Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Development 125:813-24. 1998
    ..These observations define a novel genetic pathway for inductive communication between cephalic neural crest cells and their environmental counterparts...
  42. pmc Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    A Trumpp
    G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
    Genes Dev 13:3136-48. 1999
    ..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
  43. ncbi Endothelin-1 protects astrocytes from hypoxic/ischemic injury
    M C Ho
    Institute of Molecular Biology, The University of Hong Kong, Pokfulam
    FASEB J 15:618-26. 2001
    ..The present study suggests that astrocytes without ET-1 are more vulnerable to H and H/I injuries and that the up-regulation of astrocytic ET-1 is essential for the survival of astrocytes...
  44. pmc Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy
    Ralph V Shohet
    Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:2088-93. 2004
    b>Endothelin 1 (ET-1), a potent vasoconstrictor peptide expressed by endothelium, is also produced in the heart in response to a variety of stresses...
  45. pmc Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84. 2004
    ..These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart...
  46. ncbi Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality
    Yuqiang Ge
    Division of Nephrology, University of Utah Health Sciences Center, 30 North 1900 East, Salt Lake City, Utah 84132, USA
    Am J Physiol Renal Physiol 288:F912-20. 2005
    ..These data indicate that CD ET-1 KO increases renal sensitivity to the urinary concentrating effects of AVP and suggest that ET-1 functions as a physiological autocrine regulator of AVP action in the CD...
  47. ncbi Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusion
    Justin W C Leung
    Institute of Molecular Biology, The University of Hong Kong, Hong Kong SAR, China
    J Cardiovasc Pharmacol 44:S293-300. 2004
    ..Our present TET model will serve as an ideal model for studying the role of endothelial ET- 1 in the pathogenesis of ischemic stroke...
  48. ncbi Endogenous endothelin-1 is required for cardiomyocyte survival in vivo
    Xiao Song Zhao
    Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Circulation 114:830-7. 2006
    ..To investigate the role of ET-1 in the heart, we created mice with cardiomyocyte deletion of ET-1...
  49. ncbi Klf2 is an essential regulator of vascular hemodynamic forces in vivo
    John S Lee
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 11:845-57. 2006
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...
  50. pmc Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
    Takako Makita
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 452:759-63. 2008
    ..Moreover, they suggest a model in which newborn sympathetic neurons distinguish and choose between distinct vascular trajectories to innervate their appropriate end organs...
  51. pmc An endothelin-1 switch specifies maxillomandibular identity
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:18806-11. 2008
    ..The endothelin-1 (Edn1)/endothelin receptor type-A (Ednra)-->Dlx5/6-->Hand2 signaling pathway is necessary for lower jaw formation...
  52. doi Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition
    Bambang Widyantoro
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circulation 121:2407-18. 2010
    ..The underlying mechanism, however, remains elusive. Here, we hypothesize that ET-1 might contribute to the accumulation of cardiac fibroblasts through an endothelial-to-mesenchymal transition in diabetic hearts...
  53. doi Low blood pressure in endothelial cell-specific endothelin 1 knockout mice
    Yaz Y Kisanuki
    Departments of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Tex75390 8584, USA
    Hypertension 56:121-8. 2010
    ..Taken in conjunction with other lines of genetically altered mice, our results provide evidence for a paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor...
  54. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
    ..Dlx5, Dlx6, and Hand2 genes in mesenchymal cells via inducing expression of their upstream activator, Endothelin1 (Edn1), within ectodermal cells...
  55. pmc Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure
    Nelida Olave
    Department of Pediatrics, Univ of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Physiol Lung Cell Mol Physiol 302:L857-65. 2012
    ..ETAR blockade improves function but not development of the hypoxic newborn lung. Reduction of ET-1 via inhibition of TGF-β signaling indicates that TGF-β is upstream of ET-1 during hypoxia-induced signaling in the newborn lung...
  56. doi ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy
    Suko Adiarto
    Kobe University Graduate School of Medicine, Division of Cardiovascular Medicine, Department of Internal Medicine, Japan
    Life Sci 91:651-7. 2012
    ..The exact feature of these pathways and the intercellular communications involved remain unclear. In this study, we explored the role of endothelial cell-derived ET-1 in the development of AngII-induced cardiac fibrosis and hypertrophy...
  57. pmc Coronary veins determine the pattern of sympathetic innervation in the developing heart
    Joseph Nam
    Laboratory of Stem Cell and Neuro Vascular Biology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10 6C103, 10 Center Drive, Bethesda, MD 20892, USA
    Development 140:1475-85. 2013
    ..The proposed mechanism underlies a distinct, stereotypical pattern of autonomic innervation that is adapted to the complex tissue structure and physiology of the heart...
  58. ncbi Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1
    Y Kurihara
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Nature 368:703-10. 1994
    ..These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis...
  59. pmc Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention
    Dowhan Ahn
    Division of Nephrology, University of Utah Health Sciences Center, 1900 East 30 North, Salt Lake City, UT 84132, USA
    J Clin Invest 114:504-11. 2004
    ..These studies indicate that CD-derived ET-1 is an important physiologic regulator of renal Na excretion and systemic BP...
  60. doi Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation
    Dyah W Anggrahini
    Division of Cardiovascular Medicine, Department of Internal Medicine, 7 5 1 Kusunoki, Chuo, Kobe 650 0017, Japan
    Cardiovasc Res 82:143-51. 2009
    ..In this study, we determined the role of vascular endothelial ET-1 on vascular inflammation and neointima formation using vascular endothelial ET-1-knockout [ET-1(f/f); Tie2-Cre (+)] mice...
  61. ncbi A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity
    K Saida
    Fermentation Research Institute, Agency of Industrial Science and Technology, Ibaraki, Japan
    J Biol Chem 264:14613-6. 1989
    ..Furthermore, the peptide evoked a strong contractile response in the guinea pig ileum. This peptide may thus be reasonably classified as a gastrointestinal peptide, vasoactive intestinal contractor...
  62. ncbi Endothelin-1 mRNA in glomerular and epithelial cells of kidney
    M Chen
    Department of Physiology, University of Michigan, Ann Arbor 48104
    Am J Physiol 265:F542-50. 1993
    ..Our results are consistent with the proposal that ET-1 modifies tubular function in an autocrine or paracrine fashion...
  63. ncbi Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization
    Y Kitano
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Japan
    J Bone Miner Res 13:237-44. 1998
    ..We conclude that ET-1 may regulate proliferation and migration of osteogenic cells in the maxillofacial region, rather than modulating the expression level of ON and OP mRNAs...
  64. pmc Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice
    H Yanagisawa
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    J Clin Invest 102:22-33. 1998
    ..This study demonstrates that ET-1/ETA-mediated signaling plays an essential role in a complex process of aortic arch patterning by affecting the postmigratory cardiac neural crest cell development...
  65. ncbi Genetic control of ventilation: what are we learning from murine models?
    C G Tankersley
    Division of Physiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Curr Opin Pulm Med 5:344-8. 1999
    ..At the conclusion of this review, the author emphasizes the relatively small number of studies that have incorporated the use of genomics to link differential ventilatory function to molecular structure...
  66. ncbi Role of endothelin-1 in stress response in the central nervous system
    Y Kurihara
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Am J Physiol Regul Integr Comp Physiol 279:R515-21. 2000
    ..Our findings suggest that ET-1 modulates central coordination of stress responses in close association with catecholamine metabolism...
  67. ncbi Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135
    T Kojima
    Department of Molecular Genetic Research, National Institute for Longevity Sciences NILS, Morioka cho, Oobu, Aichi, 474 8522, Japan
    Biochem Biophys Res Commun 284:1039-47. 2001
    ..The Sck-pp135 interaction was reduced by Src kinase inhibitors. These results suggest that Sck, but not N-Shc nor Shc, transmit signals in conjunction with pp135 following Src activation and/or calcium entry in the cell...
  68. ncbi beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport
    T Imamura
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
    J Biol Chem 276:43663-7. 2001
    ....
  69. ncbi Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence
    Huan Huang
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park, Bronx, New York, NY 10461, U S A
    Clin Sci (Lond) 103:263S-266S. 2002
    ..These data provide further support for a role for ET-1 in the pathogenesis of chronic chagasic heart disease, and indicate that cardiac myocytes are an important source of ET-1 in this disease...
  70. ncbi PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development
    Aaron D Gitler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 7:107-16. 2004
    ..Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis...
  71. ncbi Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype
    Johan Lundkvist
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genesis 41:13-22. 2005
    ..We discuss possible reasons for the different outcomes of the same germline CADASIL mutation in mice and humans...
  72. ncbi Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice
    F Hasue
    Department of Autonomic Physiology, 1 8 1, Nohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
    Neuroscience 130:349-58. 2005
    ..The results of the present study suggest that neuronal ET-1 is involved in endogenous pain inhibitory control likely via pathways through the hypothalamus...
  73. ncbi Endothelin-1 expression in vascular adventitial fibroblasts
    Sheng Jun An
    Dept of Community Health Sciences, Faculty of Applied Health Sciences, Brock Univ, St Catharines, ON, Canada L2S 3Y6
    Am J Physiol Heart Circ Physiol 290:H700-8. 2006
    ..mRNA levels of preproET-1 and type I procollagen were detected with relative RT-PCR...
  74. ncbi Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin II
    Weihua Ni
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Circ Res 101:985-94. 2007
    ..In summary, Ets-1 functions as a critical downstream transcriptional mediator of Ang II ROS generation by regulating the expression of NAD(P)H oxidase subunits such as p47(phox)...
  75. ncbi Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion
    Yuqiang Ge
    Division of Nephrology, Univ of Utah Health Sciences Center, 900 East 30 North, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 293:F1805-10. 2007
    ..Furthermore, the increased PGE(2) in CD ET-1 KO mice partly compensates for loss of ET-1 with respect to maintaining urinary water excretion, but not in blood pressure control...
  76. ncbi Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes
    E Miles Whitman
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L309-18. 2008
    ..These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1...
  77. doi Connexin43 is involved in the effect of endothelin-1 on astrocyte proliferation and glucose uptake
    Sandra Herrero-González
    Departamento de Bioquimica y Biologia Molecular, INCYL, Universidad de Salamanca, Spain
    Glia 57:222-33. 2009
    ..Interestingly, although the rate of growth in connexin43 KO astrocytes has been reported to be reduced, we observed that an acute reduction in connexin43 by siRNA increased proliferation and glucose uptake...
  78. doi Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortality
    Patrick Ka Kit Yeung
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 852, Hong Kong, China
    J Cereb Blood Flow Metab 29:1891-902. 2009
    ..The V(2) receptor antagonist, OPC-31260, may be one of the effective drugs for the early treatment of ET-1-induced cytotoxic edema and brain injury...
  79. doi Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1
    N F Kelland
    Clinical Pharmacology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Can J Physiol Pharmacol 88:644-51. 2010
    ..These studies suggest that EC-ETB are largely responsible for the clearance of ET-1 from the circulation...
  80. pmc Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries
    Sergio de Frutos
    Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA
    Am J Physiol Cell Physiol 301:C441-50. 2011
    ..Here, we demonstrate that ROK increases actin polymerization, thus providing structural support for NFATc3 nuclear transport...
  81. pmc Collecting duct-specific endothelin B receptor knockout increases ENaC activity
    Vladislav Bugaj
    Department of Physiology, University of Texas Health Sciences Center, San Antonio, Texas 78229, USA
    Am J Physiol Cell Physiol 302:C188-94. 2012
    ....
  82. pmc APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice
    Yi Wang
    Department of Medicine, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Diabetes 60:3044-54. 2011
    ..This study aimed to investigate the roles of the multidomain adaptor protein APPL1 in modulating vascular actions of insulin in mice and in endothelial cells...
  83. pmc Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats
    Qiaoling Zhou
    Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People s Republic of China
    PLoS ONE 7:e47360. 2012
    ..Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes...
  84. doi Suppression of osteoblast Toll-like receptor 2 signaling by endothelin-1
    Ai Suzaki
    Department of General Medicine, Surugadai Nihon University Hospital, Tokyo, Japan Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
    J Orthop Res 32:910-4. 2014
    ..As TLR2 represents an important mechanism by which osteoblasts recognize bacterial pathogens, a continuously elevated ET-1 status may impair pathogenic recognition by osteoblasts and consequently affect bone metabolism during infections...
  85. pmc Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis
    Olivia Lenoir
    Paris Cardiovascular Research Centre, Institut National de la Sante et de la Recherche Medicale, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    J Am Soc Nephrol 25:1050-62. 2014
    ..Furthermore, these results indicate that activation of the endothelin-1 pathways selectively in podocytes mediates pathophysiologic crosstalk that influences mesangial architecture and sclerosis...
  86. doi Cardiopathogenic mediators generated by GATA4 signaling upon co-activation with endothelin-1 and Trypanosoma cruzi infection
    Cristina S Rigazio
    Servicio de Parasitología Chagas, Hospital de Niños Dr Ricardo Gutierrez, Gallo 1330, 1425EFD Ciudad de Buenos Aires, Argentina
    Microb Pathog 73:47-52. 2014
    ..Our findings support a role for the GATA4 signaling pathway in the myocardial production of pathogenic mediators associated with Chagas heart disease, and may help define novel therapeutic targets. ..
  87. pmc A pathogenetic role for endothelin-1 in peritoneal dialysis-associated fibrosis
    Oscar Busnadiego
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    J Am Soc Nephrol 26:173-82. 2015
    ..These results strongly support a role for an ET-1/TGF-β1 axis as an inducer of MMT and subsequent peritoneal damage and fibrosis, and they highlight ET-1 as a potential therapeutic target in the treatment of PD-associated dysfunction. ..
  88. doi Endothelin-1 upregulation mediates aging-related cardiac fibrosis
    Xianwei Wang
    Central Arkansas Veterans Healthcare System, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Key Laboratory of Henan province for Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, Henan, China Electronic address
    J Mol Cell Cardiol 80:101-9. 2015
    ..These observations in mice and human hearts suggest that aging-related cardiac fibrosis is, at least partially, dependent on the upregulation of ET-1...
  89. pmc Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders
    André L P Tavares
    Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80108, United States
    Dev Biol 400:191-201. 2015
    Endothelin-1 (EDN1) influences both craniofacial and cardiovascular development and a number of adult physiological conditions by binding to one or both of the known endothelin receptors, thus initiating multiple signaling cascades...
  90. pmc SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1
    Rokhsana Mortuza
    Department of Pathology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    J Cell Mol Med 19:1857-67. 2015
    In diabetes, hyperglycaemia causes up-regulation of endothelin 1 (ET-1) and transforming growth factor beta 1 (TGF-β1). Previously we showed glucose reduces sirtuin1 (SIRT1), a class III histone deacetylase...
  91. doi Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors
    Lin lin Bi
    Department of Pathophysiology and Key Laboratory of Neurological Diseases of Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Neurobiol 53:2054-64. 2016
    ..Altogether, our findings establish a previously unknown anxiogenic action of ET1 in the IL cortex. AMPAR-mediated glutamatergic neurotransmission may underlie the mechanism of ET1-ET(A)R signaling pathway in the regulation of anxiety...
  92. pmc Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic Macrophages
    Sarah McKenna
    Section of Neonatology, Department of Pediatrics, Children s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045
    J Immunol 195:3866-79. 2015
    ..Together, these results mechanistically link the innate immune response mediated by IκBβ/NF-κB to ET-1 expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock. ..
  93. pmc Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration
    Jihae Shin
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Sci Rep 6:29395. 2016
    ..Our study reveals a possible molecular convergence between a neurodevelopmental defect and neurodegeneration mediated by LCDs. ..
  94. pmc Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter
    D Harats
    Syntex Discovery Research, Palo Alto, California 94303
    J Clin Invest 95:1335-44. 1995
    ..Hence, this new system can be used to direct expression of molecules to the vascular wall for the purpose of examining the biological significance of either overexpression or inhibition of select proteins...
  95. ncbi Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice
    T Nakamura
    Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 4:1064-72. 1993
    ..1-fold at 1 wk, 4.2-fold at 2 wk, and 6.2-fold at 3 wk; TNF-alpha, 2.2-fold at 1 wk, 3.8-fold at 2 wk, and 5.4-fold at 3 wk).(ABSTRACT TRUNCATED AT 250 WORDS)..
  96. ncbi Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice
    K Maemura
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Cardiovasc Pharmacol 26:S17-21. 1995
    ..ET-1 mRNA and peptide levels were in parallel with the number of Edn1 authentic alleles...
  97. pmc Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice
    M Barton
    Cardiology, University Hospital Zürich and Cardiovascular Research Laboratory, Institute of Physiology, University of Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 95:14367-72. 1998
    ..ETA receptor blockade may have therapeutic potential in patients with atherosclerosis...
  98. ncbi Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice
    H Morita
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Hypertens Res 22:11-6. 1999
    ..Mice heterozygous for the null mutation of the endothelin-1 (ET-1) gene, Edn1, may be a potential tool for studying this mechanism, because they have elevated blood pressure and disturbances in ..
  99. ncbi Development of the vertebrate ear: insights from knockouts and mutants
    D M Fekete
    Dept of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Trends Neurosci 22:263-9. 1999
    ..Genes that are regionally expressed in the inner ear can, when absent or mutated, yield selective ablation of specific inner-ear structures or cell types...
  100. ncbi Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles
    G E Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 213:418-31. 1999
    ..Implications for the development of human congenital heart defects are discussed...
  101. ncbi Analysis of the desmoplakin gene reveals striking conservation with other members of the plakin family of cytolinkers
    K J Green
    Department of Pathology, R H Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Exp Dermatol 8:462-70. 1999
    ..Detailed characterization and mapping of these genes will facilitate their further evaluation as targets of genetic disorders and provide insights into the evolutionary relationships among molecules in this emerging gene family...

Research Grants6

  1. REGULATION OF HUMAN GAMMA AND BETA GLOBIN GENES
    Joyce Lloyd; Fiscal Year: 2003
    ..These results will predict the proteins involved in early beta-globin gene suppression. ..
  2. Role of KLF2 in erythropoiesis and globin expression
    Joyce A Lloyd; Fiscal Year: 2010
    ..Our long-term goal is to use KLF2 in strategies to increase embryonic/fetal beta-globin, to treat patients with beta-hemoglobinopathies. ..
  3. Trypanosoma cruzi and AIDS: Role of the Adipocyte
    Herbert Tanowitz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  6. Differentiation in T.cruzi:an emerging AIDS pathogen
    Huan Huang; Fiscal Year: 2009
    ..To further delineate the components of this pathway, we will identify the TcPKA downstream interacting molecules, using both yeast two-hybrid assays and proteomic approaches. ..