Genomes and Genes
Gene Symbol: Eda
Alias: EDA1, Ed1, Eda-A1, Eda-A2, HED, Tnlg7c, XLHED, tabby, ectodysplasin-A, EDA protein homolog, tumor necrosis factor ligand 7c
Publications103 found, 100 shown here
- Order of loci on the X-chromosome of the mouseM F Lyon
Genet Res 7:130-3. 1966
- A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2J Collignon
Laboratory of Developmental Genetics, MRC National Institute for Medical Research, London, UK
Development 122:509-20. 1996..However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties...
- Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teethJ A Sofaer
J Embryol Exp Morphol 22:181-205. 1969
- Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic backgroundJ A Sofaer
J Embryol Exp Morphol 22:207-27. 1969
- The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesisH GRUNEBERG
J Embryol Exp Morphol 15:223-44. 1966
- Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGFJ Pispa
Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Dev Biol 216:521-34. 1999b>Tabby is a mouse mutant characterized by deficient development of the ectodermal organs: teeth, hair, and a subset of glands...
- Edar/Eda interactions regulate enamel knot formation in tooth morphogenesisA S Tucker
MRC Centre for Developmental Neurobiology, King s College, Guy s Hospital, London Bridge, London SE1 1UL, UK
Development 127:4691-700. 2000b>tabby and downless mutant mice have apparently identical defects in teeth, hair and sweat glands. Recently, genes responsible for these spontaneous mutations have been identified...
- TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesisJ Laurikkala
Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
Dev Biol 229:443-55. 2001..Our in situ hybridization analysis of the expression of ectodysplasin (encoded by the Tabby gene) and edar (encoded by the downless gene) during mouse tooth morphogenesis showed that they are expressed in ..
- Different morphotypes of functional dentition in the lower molar region of tabby (EDA) miceP Kristenová
Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
Orthod Craniofac Res 5:205-14. 2002To sort and classify the highly variable lower molar dentition in tabby (Ta) mice postnatally...
- Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland developmentTina Jaskoll
Laboratory for Developmental Genetics, University of Southern California Los Angeles, Los Angeles, California 90089 0641, USA
Anat Rec A Discov Mol Cell Evol Biol 271:322-31. 2003..Abnormal phenotypes similar to HED are seen in Tabby (Eda(Ta)) and downless (Edar(dl)) mutant mice...
- Stimulation of ectodermal organ development by Ectodysplasin-A1Tuija Mustonen
Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 259:123-36. 2003..We have overexpressed two splice forms of ectodysplasin, Eda-A1 and Eda-A2, binding to Edar and another TNF receptor, Xedar, respectively, under the keratin 14 (K14) promoter ..
- Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesisJohanna Pispa
Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
Gene Expr Patterns 3:675-9. 2003Ectodysplasin (Eda), a member of the tumor necrosis factor (TNF) superfamily, and its receptor Edar are necessary components of ectodermal organ development...
- Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair folliclesChang Yi Cui
Laboratory of Genetics, National Institutes of Health National Institute on Aging, Baltimore, MD 21224, USA
Hum Mol Genet 12:2931-40. 2003..their action further, we conditionally expressed the isoforms as tetracycline ('Tet')-regulated transgenes in Tabby (EDA-negative) and wild-type mice...
- Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiencyKim Newton
Molecular Oncology Department, Genentech, Inc, South San Francisco, California 94080, USA
Mol Cell Biol 24:1608-13. 2004b>EDA-A1 and EDA-A2 are members of the tumor necrosis factor family of ligands...
- The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestorsR Peterkova
Department of Teratology, Institute of Experimental Medicine, Academy of Sciences CR, Videnska 1083, 14220 Prague, Czech Republic
Arch Oral Biol 50:219-25. 2005A supernumerary cheek tooth occurs mesially to the first molar in tabby/EDA (Ta) mice affected by hypohidrotic ectodermal dysplasia...
- Generation of the primary hair follicle patternChunyan Mou
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
Proc Natl Acad Sci U S A 103:9075-80. 2006..This Edar-BMP activation-inhibition mechanism appears to operate alongside a labile prepattern, suggesting that Edar-mediated stabilization of beta-catenin active foci is a key event in determining definitive follicle locations...
- Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expressionMarja Pummila
Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014 Helsinki, Finland
Development 134:117-25. 2007..Ectodysplasin-A (Eda), a tumour necrosis factor-like signalling molecule, and its receptor Edar are required for the development of a ..
- The Edar subfamily in feather placode formationCaroline F Drew
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
Dev Biol 305:232-45. 2007..Our findings illustrate the roles of these three receptors during avian skin morphogenesis and also suggest that activators of feather placode fate undergo mutual regulation to reach a decision on skin appendage location and size...
- Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesisFei Liu
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Dev Biol 313:210-24. 2008....
- Disruption of the palatal rugae pattern in Tabby (eda) mutant miceCyril Charles
IPHEP, CNRS UMR 6046, Faculté SFA, Universite de Poitiers, Poitiers, France
Eur J Oral Sci 115:441-8. 2007..Therefore, we searched for and compared palatal rugae anomalies of Tabby mice bearing a mutation in the eda gene with their wild-type counterparts...
- Effect of eda loss of function on upper jugal tooth morphologyCyril Charles
IPHEP, CNRS UMR 6046, Faculté SFA, Universite de Poitiers, 40 Avenue du Recteur Pineau, Poitiers Cedex, France
Anat Rec (Hoboken) 292:299-308. 2009The Tabby/eda mice, which bear a loss of function mutation for the eda (ectodysplasinA) gene, are known to display developmental anomalies in organs with an ectodermal origin...
- The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin AA Kumar
Hamon Center for Therapeutic Oncology Research and the Division of Hematology Oncology, University of Texas Southwestern Medical Center, Dallas 75390 8593, USA
J Biol Chem 276:2668-77. 2001..Collectively, the above results suggest that EDAR utilizes a novel signal transduction pathway. Finally, ectodysplasin A can physically interact with the extracellular domain of EDAR and thus represents its biological ligand.
- Determination of a molecular map position for Hyp using a new interspecific backcross produced by in vitro fertilizationG Kay
Section of Comparative Biology, MRC Clinical Research Centre, Harrow, Middlesex, United Kingdom
Genomics 11:651-7. 1991..52 +/- 1.4 and that between Hyp and Cbx-rs1 was 1.98 +/- 1.39. Thus closely linked flanking markers for the Hyp locus that will facilitate the molecular characterization of the gene itself have been defined...
- Rps4 maps near the inactivation center on the mouse X chromosomeR M Hamvas
Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, United Kingdom
Genomics 12:363-7. 1992..The gene order Ccg-1-Rps4/Phka-Xist-Pgk-1 is conserved between mouse and human...
- Genetic mapping in the region of the mouse X-inactivation centerJ T Keer
Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, United Kingdom
Genomics 7:566-72. 1990..We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1/Pgk-1 interval...
- Construction of a detailed molecular map of the mouse X chromosome by microcloning and interspecific crossesN Brockdorff
Department of Biochemistry, St Mary s Hospital Medical School, London, UK
EMBO J 6:3291-7. 1987..Some of the mapped microclones detect moderately repetitive sequences that were clustered in several discrete regions of the mouse X chromosome...
- A-raf oncogene localizes on mouse X chromosome to region some 10-17 centimorgans proximal to hypoxanthine phosphoribosyltransferase geneP Avner
Somat Cell Mol Genet 13:267-72. 1987..This localization on the mouse X chromosome is compatible with the presence of the A-raf oncogene on the short arm of the human X chromosome between the centromere and Xp21...
- The tabby syndrome in the mouseH GRUNEBERG
Proc R Soc Lond B Biol Sci 179:139-56. 1971
- Dominance in threshold characters. A comparison of two tabby alleles in the mouseJ A Sofaer
Genetics 64:273-80. 1970
- X-linked polydactyly (Xpl), a new mutation in the mouseH O Sweet
J Hered 71:207-9. 1980..Linkage tests show that Xpl is located on the distal end of the X chromosome with the order Ta--13--jp--15--Xpl...
- Suppressed expression of the cytochrome P45017 alpha protein in the testicular feminized (Tfm) mouse testesC Le Goascogne
INSERM U 33, Lab Hormones, Le Kremlin Bicetre, France
J Endocrinol 139:127-30. 1993....
- Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domainB M Ferguson
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201 3098, USA
Hum Mol Genet 6:1589-94. 1997..We have identified a candidate cDNA for the mouse Tabby gene (Ta), which, based on phenotype and syntenic mapping, is postulated to represent the analogous murine ..
- The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domainsA K Srivastava
J C Self Research Institute of Human Genetics, Greenwood Genetic Center, SC 29646, USA
Proc Natl Acad Sci U S A 94:13069-74. 1997Mouse Tabby (Ta) and X chromosome-linked human EDA share the features of hypoplastic hair, teeth, and eccrine sweat glands. We have cloned the Ta gene and find it to be homologous to the EDA gene...
- Interactions between epidermal growth factor and the Tabby mutation in skinK Isaacs
School of Science, University of Western Sydney Nepean, Kingswood, NSW, Australia
Exp Dermatol 7:273-80. 1998Mutations of the X-linked genes Tabby (Ta) in mice and EDA in humans result in developmental and functional abnormalities, primarily in the skin and hair follicles...
- Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesionM L Mikkola
Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
Mech Dev 88:133-46. 1999In the mouse Tabby (Ta) mutant and human X-linked anhidrotic ectodermal dysplasia (EDA) syndrome development of several ectodermal organs such as hair, teeth, and sweat glands is impaired...
- Alterations in the incisor development in the Tabby mouseS Miard
INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
Int J Dev Biol 43:517-29. 1999The X-linked tabby (Ta) syndrome in the mouse is homologous to the hypohidrotic ectodermal dysplasia (HED) in humans. As in humans with HED, Ta mice exhibit hypohidrosis, characteristic defects of hairs and tooth abnormalities...
- Partial deletion of the bovine ED1 gene causes anhidrotic ectodermal dysplasia in cattleC Drogemuller
Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, 30559 Hannover, Germany
Genome Res 11:1699-705. 2001Anhidrotic ectodermal dysplasia (ED1) is characterized by hypotrichosis, reduced number of sweat glands, and incisior anodontia in human, mouse, and cattle...
- Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epitheliumR Peterkova
Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
Orthod Craniofac Res 5:215-26. 2002Prenatal identification of the different dentition morphotypes, which exist in the lower molar region of tabby (Ta) adult mice, and investigation of their origin...
- Linkage in the mouse: the sex-linked genes and RoughD S Falconer
Z Indukt Abstamm Vererbungsl 86:263-8. 1954
- Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse modelLiesbeth Vandenput
Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
J Bone Miner Res 19:1462-70. 2004..whereas cortical thickness as well as trabecular BMD and structure were fully maintained by T in the corresponding Tabby control mice...
- Electrophoretic variation for x-chromosome-linked phosphoglycerate kinase (pgk-1) in the mouseJ T Nielsen
Institute of Genetics, University of Aarhus, Aarhus, Denmark
Genetics 87:319-25. 1977..Pgk-1 showed 29/122 recombinations with Hq, 5/185 with Ta and 0/108 recombinants with Mo. Based on these recombination data, a gene order of Hq-Ta-Pgk-1-Mo is suggested...
- Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signalingOtso Häärä
Developmental Biology Program, Institute of Biotechnology, University of Helsinki, POB 56, 00014 Helsinki, Finland
Development 139:3189-99. 2012..Here, we have analyzed a signaling network involving ectodysplasin (Eda) and fibroblast growth factor 20 (Fgf20) that subtly affects tooth morphogenesis...
- Roles of dental development and adaptation in rodent evolutionHelder Gomes Rodrigues
Team Evo Devo of Vertebrate Dentition, Institut de Génomique Fonctionnelle de Lyon, ENS de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, Ecole Normale Superieure de Lyon, 32 34 avenue Tony Garnier, F 69007 Lyon, France
Nat Commun 4:2504. 2013..We find that overexpression of Eda or Edar is sufficient to produce the longitudinal crests defining stephanodonty in transgenic laboratory mice...
- Ectodysplasin A Pathway Contributes to Human and Murine Skin RepairClare L Garcin
The Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
J Invest Dermatol 136:1022-30. 2016The highly conserved ectodysplasin A (EDA)/EDA receptor signaling pathway is critical during development for the formation of skin appendages...
- Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathologyAli Azar
Developmental Biology Division
Hum Mol Genet 25:3564-3577. 2016Hypohidrotic ectodermal dysplasia (HED) results from mutation of the EDA, EDAR or EDARADD genes and is characterized by reduced or absent eccrine sweat glands, hair follicles and teeth, and defective formation of salivary, mammary and ..
- A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell DevelopmentYing Xiao
Dermatology Branch, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 12:e1006150. 2016..We found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling promoted Merkel cell morphogenesis by inducing Shh expression in early follicles...
- Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland developmentJian Sima
Laboratory of Genetics and Genomics, NIA NIH IRP, 251 Bayview Blvd, room 10B014, Baltimore, MD 21224, USA
Development 143:4723-4735. 2016..expression of Dkk4 arrests MG growth at early germ phase, which is similar to that observed in Eda-ablated Tabby mice...
- X chromosome dosage and the response to cerebral ischemiaL Christine Turtzo
Department of Neurology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurosci 31:13255-9. 2011..used to investigate the role of X chromosome dosage in female XX and XO littermates of two mouse strains (Paf and Eda(Ta))...
- Genetic and endocrine studies of the pregnancy-blocking pheromone of miceP C Hoppe
J Reprod Fertil 45:109-15. 1975..The preputial gland can be excluded as the site of pheromone synthesis since males which are hemizygous for the Tabby-J gene and have no preputial glands blocked pregnancies as effectively as their normal littermates...
- X-linked and autosomal genes controlling mouse alpha-galactosidase expressionA J Lusis
Genetics 88:327-42. 1978..Among certain recombinant inbred lines, the variation appears to segregate as a single major locus...
- The genetics of Sleek: a possible regulatory mutation of the tabby-crinkled-downless syndromeM Crocker
Genet Res 34:231-8. 1979
- High-density molecular map of the central span of the mouse X chromosomeN Brockdorff
Section of Comparative Biology, MRC Clinical Research Centre, Harrow Middlesex, United Kingdom
Genomics 10:17-22. 1991..been positioned with respect to existing DNA markers utilizing a new interspecific backcross segregating for the Tabby (Ta) locus. The density of clones within this 11.5-cM interval is now, on average, one clone every 1000 kb...
- An X-linked recessive mutation producing cleft palate, crooked tail, and polydactyly in miceJ Barra
Institut Pasteur, Unite de Genetique des Mammiferes, Paris, France
J Hered 81:388-92. 1990..It maps proximal to Tabby. Hemizygous males and homozygous females exhibit skeletal malformations of the tail, polydactyly of the hind feet, ..
- Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasiaS R Blecher
School of Human Biology, University of Guelph, Ontario, Canada
Nature 345:542-4. 1990b>Tabby (Ta), a murine X-linked mutant gene, produces a syndrome of ectodermal dysplasia including anhidrosis (absence of sweat glands)...
- Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse crossP Avner
Proc Natl Acad Sci U S A 84:1629-33. 1987..X chromosome using an interspecific cross involving Mus spretus to a contiguous region lying proximally to the Tabby (Ta) locus. Pedigree and recombinational analysis establish the marker order as being Hprt-FIX-c11-G6PD-St14-1...
- Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouseL C Amar
Unité INSERM U 276, Institut Pasteur, Paris, France
Genomics 2:220-30. 1988....
- The localization of G6pd, glucose-6-phosphate dehydrogenase, and mdx, muscular dystrophy in the mouse X chromosomeJ Peters
Genet Res 52:195-201. 1988
- Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosomeR Heilig
Nature 328:168-70. 1987..Both sequences map to the region of 10 centimorgan lying between the Tabby (Ta) and St14-1 (DxPas8) loci, close to the phosphorylase b kinase locus (Phk)...
- Genetic activity of sex chromosomes in somatic cells of mammalsM F Lyon
Philos Trans R Soc Lond B Biol Sci 259:41-52. 1970
- A comparative study of the coats of chimaeric mice and those of heterozygotes for X-linked genesB M Cattanach
Genet Res 19:213-28. 1972
- Location of phosphorylase kinase (Phk) in the mouse X chromosomeF Huijing
Biochem Genet 9:193-6. 1973
- Threshold phenomena versus cell heredity in the manifestation of sex-linked genes in mammalsH GRUNEBERG
J Embryol Exp Morphol 22:145-79. 1969
- X-linked gene for testicular feminization in the mouseM F Lyon
Nature 227:1217-9. 1970
- The glandular aspects of the tabby syndrome in the mouseH GRUNEBERG
J Embryol Exp Morphol 25:1-19. 1971
- X chromosome-linked muscular dystrophy (mdx) in the mouseG Bulfield
Proc Natl Acad Sci U S A 81:1189-92. 1984..Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome...
- Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genesH Sakano
Nature 286:676-83. 1980..The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms...
- Jimpy 4J: a new X-linked mouse mutation producing severe CNS hypomyelinationS Billings-Gagliardi
University of Massachusetts Medical School, Department of Cell Biology, Worcester 01655, USA
Dev Neurosci 17:300-10. 1995....
- Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer miceC Le Goascogne
INSERM U 488, Bicetre, France
Glia 29:14-24. 2000..The role of PROG in myelin repair is discussed...
- Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantationD S Johnston
School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman 99164, USA
Endocrinology 142:2405-8. 2001....
- Mutation of the ectodysplasin-A gene results in bone defects in miceN L Hill
Department of Biological Sciences, The University of Delaware, Newark, DE 19716, USA
J Comp Pathol 126:220-5. 2002..An animal model of EDA, the Tabby mouse, also has mutations in the ectodysplasin-A gene and defects similar to those of human beings with EDA...
- Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor EdarJohanna Laurikkala
Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
Development 129:2541-53. 2002..The recent cloning of the genes that underlie these syndromes, ectodysplasin (ED1) and the ectodysplasin A receptor (EDAR), and their identification as a novel TNF ligand-receptor pair suggested a role for TNF ..
- Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathwaysM Cerghet
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Neurocytol 30:841-55. 2001..Our data shows for the first time, in vivo, that mutations in Plp gene increase oligodendrocyte death by activating the caspase cascade but the trigger to upregulate this cascade follows different pathways...
- [Total sex-linkage in the house mouse]D S Falconer
Z Indukt Abstamm Vererbungsl 85:210-9. 1953
- Ectodysplasin regulates pattern formation in the mammalian hair coatMin Zhang
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
Genesis 37:30-7. 2003..Here we present evidence of follicular patterning by ectodysplasin-A1 (Eda-A1), a signaling protein necessary for the proper development of hair and other appendages...
- The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificitySarah G Hymowitz
Department of Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Structure 11:1513-20. 2003b>EDA is a tumor necrosis factor family member involved in ectodermal development. Splice variants EDA-A1 and EDA-A2 differ only by the presence of Glu 308 and Val 309 in the expected receptor binding region of EDA-A1 but not EDA-A2...
- The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth developmentA S Tucker
Craniofacial Development, Dental Institute, Guy s Hospital, King s College London, London SE1 9RT, UK
Dev Biol 268:185-94. 2004..of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice...
- Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendagesTuija Mustonen
Developmental Biology Program, Institute of Biotechnology, PO Box 56 Viikinkaari 9, University of Helsinki, Finland
Development 131:4907-19. 2004..Ectodysplasin (Eda) is a unique signalling molecule in the tumour necrosis factor family that, together with its receptor Edar, is ..
- Nonindependence of mammalian dental charactersAapo T Kangas
Developmental Biology Program, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
Nature 432:211-4. 2004..We investigated how three different levels of the cell signalling protein ectodysplasin (Eda) changed dental characters in mouse...
- Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA miceT Boran
Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the CR, Prague, Czech Republic
J Dent Res 84:228-33. 2005..could also be involved in the reduction of tooth number and the determination of anomalous tooth boundaries in tabby (Ta)/EDA mice...
- Intercellular growth factor signaling and the development of mouse tracheal submucosal glandsEmma L Rawlins
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Dev Dyn 233:1378-85. 2005..Glands are completely absent in mice lacking Ectodysplasin (Eda) and Edaradd (Eda receptor adaptor protein), members of the tumor necrosis (TNF) superfamily of signaling factors...
- Repertoire of mouse ectodysplasin-A (EDA-A) isoformsTsuyoshi Hashimoto
Laboratory of Genetics, NIH National Institute on Aging, Baltimore, MD 21224, USA
Gene 371:42-51. 2006..Isoform EDA-A1 protein shows partial rescue of the affected Tabby mouse phenotypes, suggesting that other isoforms may be required for full function...
- EDA signaling and skin appendage developmentChang Yi Cui
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Cell Cycle 5:2477-83. 2006..For developing skin appendages, a model for tissue-specific regulation of signaling is provided by the EDA pathway, which accesses the otherwise ubiquitous NFkappaB transcription factors...
- Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairsBrigitte Hammerschmidt
Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
Dev Biol 305:246-61. 2007..Moreover, the identified molecular hierarchy offers a model for the periodic patterning of zigzag hairs mechanistically similar to mesodermal segmentation...
- An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contributionAbigail K Langton
Faculty of Life Sciences, University of Manchester, Manchester, UK
J Invest Dermatol 128:1311-8. 2008..JID Journal Club article: for questions, answers, and open discussion about this article please go to http://network.nature.com/group/jidclub...
- Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formationKatja Närhi
Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN 00014, Helsinki, Finland
Development 135:1019-28. 2008..of beta-catenin resulted in precocious and excessive induction of hair follicles even in the absence of Eda/Edar signaling, a pathway essential for primary hair placode formation...
- Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodesIngrid Fliniaux
Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014, Helsinki, Finland
Dev Biol 320:60-71. 2008..Ectodysplasin-A1 (Eda-A1) and Wnts are high in hierarchy of placode activators...
- Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant miceDiana Esibizione
Laboratory of Genetics, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
Gene 427:42-6. 2008..earlier used expression profiling to infer genes differentially expressed at various developmental time points in Tabby (Eda-deficient) compared to wild-type mouse skin...
- Requirement for Shh and Fox family genes at different stages in sweat gland developmentMakoto Kunisada
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, MD 21224, USA
Hum Mol Genet 18:1769-78. 2009..To initiate analyses, we compared the model of Eda mutant Tabby mice, in which sweat glands were not formed, with wild-type (WT) mice...
- Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle inductionYuhang Zhang
Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Dev Cell 17:49-61. 2009..Wnt/beta-catenin signaling is initially activated independently of EDA/EDAR/NF-kappaB activity in primary hair follicle primordia...
- Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hairChang Yi Cui
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
PLoS ONE 5:e10009. 2010..Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda(-/y)) mice still make secondary hair...
- A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1G F Kay
Section of Comparative Biology, MRC Clinical Research Centre, Harrow, UK
Nature 354:486-9. 1991..These Y-linked genes may form part of a coregulated group of genes which function during spermatogenesis...
- Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosomeJ Nasir
Department of Biochemistry and Molecular Genetics, Saint Mary s Hospital Medical School, London, United Kingdom
Proc Natl Acad Sci U S A 87:399-403. 1990..First, the repeat sequence island encompasses a 1-megabase region devoid of CpG islands; second, it features a high concentration of L1 long interspersed repeat sequences...
- Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse crossL C Amar
EMBO J 4:3695-700. 1985..and SPE/Pas mouse strains segregating the X chromosome markers hypoxanthine phosphoribosyl transferase (Hprt) and Tabby (Ta). Three of the probes map to the region between the centromere and Hprt, and two distal to Ta...
- The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymusJ P DiSanto
INSERM U132, Hopital Necker Enfants Malades, Institut Pasteur, Paris, France
Eur J Immunol 24:3014-8. 1994..Genomic clones for the murine IL-2R gamma will allow for further studies on the regulation and function of this gene in vivo...
- Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 2. Follicle morphogenesis in the hair mutants, Tabby and downyU Vielkind
Department of Biomedical Sciences, University of Guelph, Ont, Canada
Acta Anat (Basel) 157:183-94. 1996Wild-type mice have three main types of hair in their pelage: tylotrichs, awls and zigzags. Tabby mice have a yellowish coat consisting of awls only, whereas downy mice have a sparse grayish coat consisting of unusually fine hairs...
- Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryosR V Jamieson
Embryology Unit, Children s Medical Research Institute, Wentworthville, New South Wales, Australia
Dev Biol 199:235-44. 1998....
- Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouseC D Vulpe
Howard Hughes Medical Institute and the Department of Medicine, University of California at San Francisco, 94143, USA
Nat Genet 21:195-9. 1999..We suggest that the hephaestin protein is a multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation and that it is an important link between copper and iron metabolism in mammals...
- Androgens indirectly accelerate thymocyte apoptosisG J Dulos
Department of Pharmacology, N V Organon, Oss, The Netherlands
Int Immunopharmacol 1:321-8. 2001..Thus, it is concluded that androgens indirectly accelerate thymocyte apoptosis in vivo...
- Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesisThomas Aberg
Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 270:76-93. 2004..We conclude that Runx2 mediates the functions of epithelial FGF signals regulating Fgf3 expression in the dental mesenchyme and that Fgf3 may be a direct target gene of Runx2...
- NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growthRuth Schmidt-Ullrich
Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
Development 133:1045-57. 2006..Furthermore, the similarity between the phenotypes of c(IkappaBADeltaN) mice and mice deficient in Eda A1 (tabby) or its receptor EdaR (downless) raised the issue of whether in vivo NF-kappaB regulates or is regulated by ..
- Controlling Apoptosis in OligondendrocytesPamela Knapp; Fiscal Year: 2005..Specific Aim 4: Biochemical and histological techniques are used to determine whether pathways which are independent of caspase-3 play a significant role in cell loss after SCI. ..
- Opioids Modulate Oligodendrocyte Development & FunctionPamela Knapp; Fiscal Year: 2006..Techniques used include cell culture, immunostaining, in situ hybridization, immunoblot, confocal microscopy and adenoviral transfection. ..