Eda

Summary

Gene Symbol: Eda
Description: ectodysplasin-A
Alias: EDA1, Ed1, Eda-A1, Eda-A2, HED, Tnlg7c, XLHED, tabby, ectodysplasin-A, EDA protein homolog, tumor necrosis factor ligand 7c
Species: mouse

Top Publications

  1. ncbi Order of loci on the X-chromosome of the mouse
    M F Lyon
    Genet Res 7:130-3. 1966
  2. ncbi A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
    J Collignon
    Laboratory of Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Development 122:509-20. 1996
  3. ncbi Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teeth
    J A Sofaer
    J Embryol Exp Morphol 22:181-205. 1969
  4. ncbi Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic background
    J A Sofaer
    J Embryol Exp Morphol 22:207-27. 1969
  5. ncbi The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis
    H GRUNEBERG
    J Embryol Exp Morphol 15:223-44. 1966
  6. ncbi Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
  7. ncbi Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis
    A S Tucker
    MRC Centre for Developmental Neurobiology, King s College, Guy s Hospital, London Bridge, London SE1 1UL, UK
    Development 127:4691-700. 2000
  8. ncbi TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis
    J Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 229:443-55. 2001
  9. ncbi Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice
    P Kristenová
    Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
    Orthod Craniofac Res 5:205-14. 2002
  10. ncbi Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California Los Angeles, Los Angeles, California 90089 0641, USA
    Anat Rec A Discov Mol Cell Evol Biol 271:322-31. 2003

Research Grants

Scientific Experts

  • Renata Peterkova
  • J Pispa
  • Greagory Guzauskas
  • Chang Yi Cui
  • Jian Sima
  • S Risnes
  • Tina Jaskoll
  • Sarah G Hymowitz
  • Ruth Schmidt-Ullrich
  • G J Dulos
  • M L Mikkola
  • Betsy Ferguson
  • Pamela Knapp
  • Cyril Charles
  • Sophie Pantalacci
  • Irma Thesleff
  • Ingrid Fliniaux
  • Pascal Schneider
  • Marja Pummila
  • Jukka Jernvall
  • Yuhang Zhang
  • Aapo T Kangas
  • Johanna Laurikkala
  • Tuija Mustonen
  • David Schlessinger
  • Clare L Garcin
  • Ying Xiao
  • Ali Azar
  • Denis J Headon
  • Thomas Aberg
  • Denis Headon
  • Chunyan Mou
  • A S Tucker
  • Helder Gomes Rodrigues
  • Risto Jaatinen
  • Otso Häärä
  • L Christine Turtzo
  • Makoto Kunisada
  • Natalie M Gallant
  • Thomas Andl
  • Walter Birchmeier
  • Stefano Piccolo
  • Edward E Morrisey
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  • Makoto M Taketo
  • Abigail K Langton
  • Katja Närhi
  • Diana Esibizione
  • H Lesot
  • Fei Liu
  • M Peterka
  • Paul A Overbeek
  • Caroline F Drew
  • Brigitte Hammerschmidt
  • Tsuyoshi Hashimoto
  • T Boran
  • Emma L Rawlins
  • Kim Newton
  • Liesbeth Vandenput
  • Helen Brown
  • Neil Kirby
  • Matthew J Hardman
  • Michael Cheeseman
  • Jonathan S Williams
  • C Le Goascogne
  • RADHIKA P ATIT
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Detail Information

Publications103 found, 100 shown here

  1. ncbi Order of loci on the X-chromosome of the mouse
    M F Lyon
    Genet Res 7:130-3. 1966
  2. ncbi A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
    J Collignon
    Laboratory of Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Development 122:509-20. 1996
    ..However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties...
  3. ncbi Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teeth
    J A Sofaer
    J Embryol Exp Morphol 22:181-205. 1969
  4. ncbi Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic background
    J A Sofaer
    J Embryol Exp Morphol 22:207-27. 1969
  5. ncbi The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis
    H GRUNEBERG
    J Embryol Exp Morphol 15:223-44. 1966
  6. ncbi Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
    b>Tabby is a mouse mutant characterized by deficient development of the ectodermal organs: teeth, hair, and a subset of glands...
  7. ncbi Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis
    A S Tucker
    MRC Centre for Developmental Neurobiology, King s College, Guy s Hospital, London Bridge, London SE1 1UL, UK
    Development 127:4691-700. 2000
    b>tabby and downless mutant mice have apparently identical defects in teeth, hair and sweat glands. Recently, genes responsible for these spontaneous mutations have been identified...
  8. ncbi TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis
    J Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 229:443-55. 2001
    ..Our in situ hybridization analysis of the expression of ectodysplasin (encoded by the Tabby gene) and edar (encoded by the downless gene) during mouse tooth morphogenesis showed that they are expressed in ..
  9. ncbi Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice
    P Kristenová
    Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
    Orthod Craniofac Res 5:205-14. 2002
    To sort and classify the highly variable lower molar dentition in tabby (Ta) mice postnatally...
  10. ncbi Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California Los Angeles, Los Angeles, California 90089 0641, USA
    Anat Rec A Discov Mol Cell Evol Biol 271:322-31. 2003
    ..Abnormal phenotypes similar to HED are seen in Tabby (Eda(Ta)) and downless (Edar(dl)) mutant mice...
  11. ncbi Stimulation of ectodermal organ development by Ectodysplasin-A1
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 259:123-36. 2003
    ..We have overexpressed two splice forms of ectodysplasin, Eda-A1 and Eda-A2, binding to Edar and another TNF receptor, Xedar, respectively, under the keratin 14 (K14) promoter ..
  12. ncbi Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Gene Expr Patterns 3:675-9. 2003
    Ectodysplasin (Eda), a member of the tumor necrosis factor (TNF) superfamily, and its receptor Edar are necessary components of ectodermal organ development...
  13. ncbi Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles
    Chang Yi Cui
    Laboratory of Genetics, National Institutes of Health National Institute on Aging, Baltimore, MD 21224, USA
    Hum Mol Genet 12:2931-40. 2003
    ..their action further, we conditionally expressed the isoforms as tetracycline ('Tet')-regulated transgenes in Tabby (EDA-negative) and wild-type mice...
  14. pmc Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency
    Kim Newton
    Molecular Oncology Department, Genentech, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 24:1608-13. 2004
    b>EDA-A1 and EDA-A2 are members of the tumor necrosis factor family of ligands...
  15. ncbi The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors
    R Peterkova
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences CR, Videnska 1083, 14220 Prague, Czech Republic
    Arch Oral Biol 50:219-25. 2005
    A supernumerary cheek tooth occurs mesially to the first molar in tabby/EDA (Ta) mice affected by hypohidrotic ectodermal dysplasia...
  16. pmc Generation of the primary hair follicle pattern
    Chunyan Mou
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 103:9075-80. 2006
    ..This Edar-BMP activation-inhibition mechanism appears to operate alongside a labile prepattern, suggesting that Edar-mediated stabilization of beta-catenin active foci is a key event in determining definitive follicle locations...
  17. ncbi Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression
    Marja Pummila
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014 Helsinki, Finland
    Development 134:117-25. 2007
    ..Ectodysplasin-A (Eda), a tumour necrosis factor-like signalling molecule, and its receptor Edar are required for the development of a ..
  18. pmc The Edar subfamily in feather placode formation
    Caroline F Drew
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Dev Biol 305:232-45. 2007
    ..Our findings illustrate the roles of these three receptors during avian skin morphogenesis and also suggest that activators of feather placode fate undergo mutual regulation to reach a decision on skin appendage location and size...
  19. pmc Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis
    Fei Liu
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Biol 313:210-24. 2008
    ....
  20. ncbi Disruption of the palatal rugae pattern in Tabby (eda) mutant mice
    Cyril Charles
    IPHEP, CNRS UMR 6046, Faculté SFA, Universite de Poitiers, Poitiers, France
    Eur J Oral Sci 115:441-8. 2007
    ..Therefore, we searched for and compared palatal rugae anomalies of Tabby mice bearing a mutation in the eda gene with their wild-type counterparts...
  21. doi Effect of eda loss of function on upper jugal tooth morphology
    Cyril Charles
    IPHEP, CNRS UMR 6046, Faculté SFA, Universite de Poitiers, 40 Avenue du Recteur Pineau, Poitiers Cedex, France
    Anat Rec (Hoboken) 292:299-308. 2009
    The Tabby/eda mice, which bear a loss of function mutation for the eda (ectodysplasinA) gene, are known to display developmental anomalies in organs with an ectodermal origin...
  22. ncbi The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A
    A Kumar
    Hamon Center for Therapeutic Oncology Research and the Division of Hematology Oncology, University of Texas Southwestern Medical Center, Dallas 75390 8593, USA
    J Biol Chem 276:2668-77. 2001
    ..Collectively, the above results suggest that EDAR utilizes a novel signal transduction pathway. Finally, ectodysplasin A can physically interact with the extracellular domain of EDAR and thus represents its biological ligand.
  23. ncbi Determination of a molecular map position for Hyp using a new interspecific backcross produced by in vitro fertilization
    G Kay
    Section of Comparative Biology, MRC Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Genomics 11:651-7. 1991
    ..52 +/- 1.4 and that between Hyp and Cbx-rs1 was 1.98 +/- 1.39. Thus closely linked flanking markers for the Hyp locus that will facilitate the molecular characterization of the gene itself have been defined...
  24. ncbi Rps4 maps near the inactivation center on the mouse X chromosome
    R M Hamvas
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, United Kingdom
    Genomics 12:363-7. 1992
    ..The gene order Ccg-1-Rps4/Phka-Xist-Pgk-1 is conserved between mouse and human...
  25. ncbi Genetic mapping in the region of the mouse X-inactivation center
    J T Keer
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, United Kingdom
    Genomics 7:566-72. 1990
    ..We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1/Pgk-1 interval...
  26. pmc Construction of a detailed molecular map of the mouse X chromosome by microcloning and interspecific crosses
    N Brockdorff
    Department of Biochemistry, St Mary s Hospital Medical School, London, UK
    EMBO J 6:3291-7. 1987
    ..Some of the mapped microclones detect moderately repetitive sequences that were clustered in several discrete regions of the mouse X chromosome...
  27. ncbi A-raf oncogene localizes on mouse X chromosome to region some 10-17 centimorgans proximal to hypoxanthine phosphoribosyltransferase gene
    P Avner
    Somat Cell Mol Genet 13:267-72. 1987
    ..This localization on the mouse X chromosome is compatible with the presence of the A-raf oncogene on the short arm of the human X chromosome between the centromere and Xp21...
  28. ncbi The tabby syndrome in the mouse
    H GRUNEBERG
    Proc R Soc Lond B Biol Sci 179:139-56. 1971
  29. pmc Dominance in threshold characters. A comparison of two tabby alleles in the mouse
    J A Sofaer
    Genetics 64:273-80. 1970
  30. ncbi X-linked polydactyly (Xpl), a new mutation in the mouse
    H O Sweet
    J Hered 71:207-9. 1980
    ..Linkage tests show that Xpl is located on the distal end of the X chromosome with the order Ta--13--jp--15--Xpl...
  31. ncbi Suppressed expression of the cytochrome P45017 alpha protein in the testicular feminized (Tfm) mouse testes
    C Le Goascogne
    INSERM U 33, Lab Hormones, Le Kremlin Bicetre, France
    J Endocrinol 139:127-30. 1993
    ....
  32. ncbi Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain
    B M Ferguson
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201 3098, USA
    Hum Mol Genet 6:1589-94. 1997
    ..We have identified a candidate cDNA for the mouse Tabby gene (Ta), which, based on phenotype and syntenic mapping, is postulated to represent the analogous murine ..
  33. pmc The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains
    A K Srivastava
    J C Self Research Institute of Human Genetics, Greenwood Genetic Center, SC 29646, USA
    Proc Natl Acad Sci U S A 94:13069-74. 1997
    Mouse Tabby (Ta) and X chromosome-linked human EDA share the features of hypoplastic hair, teeth, and eccrine sweat glands. We have cloned the Ta gene and find it to be homologous to the EDA gene...
  34. ncbi Interactions between epidermal growth factor and the Tabby mutation in skin
    K Isaacs
    School of Science, University of Western Sydney Nepean, Kingswood, NSW, Australia
    Exp Dermatol 7:273-80. 1998
    Mutations of the X-linked genes Tabby (Ta) in mice and EDA in humans result in developmental and functional abnormalities, primarily in the skin and hair follicles...
  35. ncbi Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion
    M L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
    Mech Dev 88:133-46. 1999
    In the mouse Tabby (Ta) mutant and human X-linked anhidrotic ectodermal dysplasia (EDA) syndrome development of several ectodermal organs such as hair, teeth, and sweat glands is impaired...
  36. ncbi Alterations in the incisor development in the Tabby mouse
    S Miard
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 43:517-29. 1999
    The X-linked tabby (Ta) syndrome in the mouse is homologous to the hypohidrotic ectodermal dysplasia (HED) in humans. As in humans with HED, Ta mice exhibit hypohidrosis, characteristic defects of hairs and tooth abnormalities...
  37. pmc Partial deletion of the bovine ED1 gene causes anhidrotic ectodermal dysplasia in cattle
    C Drogemuller
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, 30559 Hannover, Germany
    Genome Res 11:1699-705. 2001
    Anhidrotic ectodermal dysplasia (ED1) is characterized by hypotrichosis, reduced number of sweat glands, and incisior anodontia in human, mouse, and cattle...
  38. ncbi Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epithelium
    R Peterkova
    Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
    Orthod Craniofac Res 5:215-26. 2002
    Prenatal identification of the different dentition morphotypes, which exist in the lower molar region of tabby (Ta) adult mice, and investigation of their origin...
  39. ncbi Linkage in the mouse: the sex-linked genes and Rough
    D S Falconer
    Z Indukt Abstamm Vererbungsl 86:263-8. 1954
  40. ncbi Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model
    Liesbeth Vandenput
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Bone Miner Res 19:1462-70. 2004
    ..whereas cortical thickness as well as trabecular BMD and structure were fully maintained by T in the corresponding Tabby control mice...
  41. pmc Electrophoretic variation for x-chromosome-linked phosphoglycerate kinase (pgk-1) in the mouse
    J T Nielsen
    Institute of Genetics, University of Aarhus, Aarhus, Denmark
    Genetics 87:319-25. 1977
    ..Pgk-1 showed 29/122 recombinations with Hq, 5/185 with Ta and 0/108 recombinants with Mo. Based on these recombination data, a gene order of Hq-Ta-Pgk-1-Mo is suggested...
  42. pmc Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling
    Otso Häärä
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, POB 56, 00014 Helsinki, Finland
    Development 139:3189-99. 2012
    ..Here, we have analyzed a signaling network involving ectodysplasin (Eda) and fibroblast growth factor 20 (Fgf20) that subtly affects tooth morphogenesis...
  43. doi Roles of dental development and adaptation in rodent evolution
    Helder Gomes Rodrigues
    Team Evo Devo of Vertebrate Dentition, Institut de Génomique Fonctionnelle de Lyon, ENS de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, Ecole Normale Superieure de Lyon, 32 34 avenue Tony Garnier, F 69007 Lyon, France
    Nat Commun 4:2504. 2013
    ..We find that overexpression of Eda or Edar is sufficient to produce the longitudinal crests defining stephanodonty in transgenic laboratory mice...
  44. pmc Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair
    Clare L Garcin
    The Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Invest Dermatol 136:1022-30. 2016
    The highly conserved ectodysplasin A (EDA)/EDA receptor signaling pathway is critical during development for the formation of skin appendages...
  45. pmc Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology
    Ali Azar
    Developmental Biology Division
    Hum Mol Genet 25:3564-3577. 2016
    Hypohidrotic ectodermal dysplasia (HED) results from mutation of the EDA, EDAR or EDARADD genes and is characterized by reduced or absent eccrine sweat glands, hair follicles and teeth, and defective formation of salivary, mammary and ..
  46. pmc A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development
    Ying Xiao
    Dermatology Branch, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 12:e1006150. 2016
    ..We found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling promoted Merkel cell morphogenesis by inducing Shh expression in early follicles...
  47. pmc Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development
    Jian Sima
    Laboratory of Genetics and Genomics, NIA NIH IRP, 251 Bayview Blvd, room 10B014, Baltimore, MD 21224, USA
    Development 143:4723-4735. 2016
    ..expression of Dkk4 arrests MG growth at early germ phase, which is similar to that observed in Eda-ablated Tabby mice...
  48. pmc X chromosome dosage and the response to cerebral ischemia
    L Christine Turtzo
    Department of Neurology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 31:13255-9. 2011
    ..used to investigate the role of X chromosome dosage in female XX and XO littermates of two mouse strains (Paf and Eda(Ta))...
  49. ncbi Genetic and endocrine studies of the pregnancy-blocking pheromone of mice
    P C Hoppe
    J Reprod Fertil 45:109-15. 1975
    ..The preputial gland can be excluded as the site of pheromone synthesis since males which are hemizygous for the Tabby-J gene and have no preputial glands blocked pregnancies as effectively as their normal littermates...
  50. pmc X-linked and autosomal genes controlling mouse alpha-galactosidase expression
    A J Lusis
    Genetics 88:327-42. 1978
    ..Among certain recombinant inbred lines, the variation appears to segregate as a single major locus...
  51. ncbi The genetics of Sleek: a possible regulatory mutation of the tabby-crinkled-downless syndrome
    M Crocker
    Genet Res 34:231-8. 1979
  52. ncbi High-density molecular map of the central span of the mouse X chromosome
    N Brockdorff
    Section of Comparative Biology, MRC Clinical Research Centre, Harrow Middlesex, United Kingdom
    Genomics 10:17-22. 1991
    ..been positioned with respect to existing DNA markers utilizing a new interspecific backcross segregating for the Tabby (Ta) locus. The density of clones within this 11.5-cM interval is now, on average, one clone every 1000 kb...
  53. ncbi An X-linked recessive mutation producing cleft palate, crooked tail, and polydactyly in mice
    J Barra
    Institut Pasteur, Unite de Genetique des Mammiferes, Paris, France
    J Hered 81:388-92. 1990
    ..It maps proximal to Tabby. Hemizygous males and homozygous females exhibit skeletal malformations of the tail, polydactyly of the hind feet, ..
  54. ncbi Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia
    S R Blecher
    School of Human Biology, University of Guelph, Ontario, Canada
    Nature 345:542-4. 1990
    b>Tabby (Ta), a murine X-linked mutant gene, produces a syndrome of ectodermal dysplasia including anhidrosis (absence of sweat glands)...
  55. pmc Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross
    P Avner
    Proc Natl Acad Sci U S A 84:1629-33. 1987
    ..X chromosome using an interspecific cross involving Mus spretus to a contiguous region lying proximally to the Tabby (Ta) locus. Pedigree and recombinational analysis establish the marker order as being Hprt-FIX-c11-G6PD-St14-1...
  56. ncbi Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse
    L C Amar
    Unité INSERM U 276, Institut Pasteur, Paris, France
    Genomics 2:220-30. 1988
    ....
  57. ncbi The localization of G6pd, glucose-6-phosphate dehydrogenase, and mdx, muscular dystrophy in the mouse X chromosome
    J Peters
    Genet Res 52:195-201. 1988
  58. ncbi Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome
    R Heilig
    Nature 328:168-70. 1987
    ..Both sequences map to the region of 10 centimorgan lying between the Tabby (Ta) and St14-1 (DxPas8) loci, close to the phosphorylase b kinase locus (Phk)...
  59. ncbi Genetic activity of sex chromosomes in somatic cells of mammals
    M F Lyon
    Philos Trans R Soc Lond B Biol Sci 259:41-52. 1970
  60. ncbi A comparative study of the coats of chimaeric mice and those of heterozygotes for X-linked genes
    B M Cattanach
    Genet Res 19:213-28. 1972
  61. ncbi Location of phosphorylase kinase (Phk) in the mouse X chromosome
    F Huijing
    Biochem Genet 9:193-6. 1973
  62. ncbi Threshold phenomena versus cell heredity in the manifestation of sex-linked genes in mammals
    H GRUNEBERG
    J Embryol Exp Morphol 22:145-79. 1969
  63. ncbi X-linked gene for testicular feminization in the mouse
    M F Lyon
    Nature 227:1217-9. 1970
  64. ncbi The glandular aspects of the tabby syndrome in the mouse
    H GRUNEBERG
    J Embryol Exp Morphol 25:1-19. 1971
  65. pmc X chromosome-linked muscular dystrophy (mdx) in the mouse
    G Bulfield
    Proc Natl Acad Sci U S A 81:1189-92. 1984
    ..Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome...
  66. ncbi Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
    H Sakano
    Nature 286:676-83. 1980
    ..The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms...
  67. ncbi Jimpy 4J: a new X-linked mouse mutation producing severe CNS hypomyelination
    S Billings-Gagliardi
    University of Massachusetts Medical School, Department of Cell Biology, Worcester 01655, USA
    Dev Neurosci 17:300-10. 1995
    ....
  68. ncbi Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice
    C Le Goascogne
    INSERM U 488, Bicetre, France
    Glia 29:14-24. 2000
    ..The role of PROG in myelin repair is discussed...
  69. ncbi Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation
    D S Johnston
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman 99164, USA
    Endocrinology 142:2405-8. 2001
    ....
  70. ncbi Mutation of the ectodysplasin-A gene results in bone defects in mice
    N L Hill
    Department of Biological Sciences, The University of Delaware, Newark, DE 19716, USA
    J Comp Pathol 126:220-5. 2002
    ..An animal model of EDA, the Tabby mouse, also has mutations in the ectodysplasin-A gene and defects similar to those of human beings with EDA...
  71. ncbi Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Development 129:2541-53. 2002
    ..The recent cloning of the genes that underlie these syndromes, ectodysplasin (ED1) and the ectodysplasin A receptor (EDAR), and their identification as a novel TNF ligand-receptor pair suggested a role for TNF ..
  72. ncbi Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways
    M Cerghet
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Neurocytol 30:841-55. 2001
    ..Our data shows for the first time, in vivo, that mutations in Plp gene increase oligodendrocyte death by activating the caspase cascade but the trigger to upregulate this cascade follows different pathways...
  73. ncbi [Total sex-linkage in the house mouse]
    D S Falconer
    Z Indukt Abstamm Vererbungsl 85:210-9. 1953
  74. ncbi Ectodysplasin regulates pattern formation in the mammalian hair coat
    Min Zhang
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Genesis 37:30-7. 2003
    ..Here we present evidence of follicular patterning by ectodysplasin-A1 (Eda-A1), a signaling protein necessary for the proper development of hair and other appendages...
  75. ncbi The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity
    Sarah G Hymowitz
    Department of Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Structure 11:1513-20. 2003
    b>EDA is a tumor necrosis factor family member involved in ectodermal development. Splice variants EDA-A1 and EDA-A2 differ only by the presence of Glu 308 and Val 309 in the expected receptor binding region of EDA-A1 but not EDA-A2...
  76. ncbi The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development
    A S Tucker
    Craniofacial Development, Dental Institute, Guy s Hospital, King s College London, London SE1 9RT, UK
    Dev Biol 268:185-94. 2004
    ..of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice...
  77. ncbi Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, PO Box 56 Viikinkaari 9, University of Helsinki, Finland
    Development 131:4907-19. 2004
    ..Ectodysplasin (Eda) is a unique signalling molecule in the tumour necrosis factor family that, together with its receptor Edar, is ..
  78. ncbi Nonindependence of mammalian dental characters
    Aapo T Kangas
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Nature 432:211-4. 2004
    ..We investigated how three different levels of the cell signalling protein ectodysplasin (Eda) changed dental characters in mouse...
  79. ncbi Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice
    T Boran
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the CR, Prague, Czech Republic
    J Dent Res 84:228-33. 2005
    ..could also be involved in the reduction of tooth number and the determination of anomalous tooth boundaries in tabby (Ta)/EDA mice...
  80. ncbi Intercellular growth factor signaling and the development of mouse tracheal submucosal glands
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Dyn 233:1378-85. 2005
    ..Glands are completely absent in mice lacking Ectodysplasin (Eda) and Edaradd (Eda receptor adaptor protein), members of the tumor necrosis (TNF) superfamily of signaling factors...
  81. ncbi Repertoire of mouse ectodysplasin-A (EDA-A) isoforms
    Tsuyoshi Hashimoto
    Laboratory of Genetics, NIH National Institute on Aging, Baltimore, MD 21224, USA
    Gene 371:42-51. 2006
    ..Isoform EDA-A1 protein shows partial rescue of the affected Tabby mouse phenotypes, suggesting that other isoforms may be required for full function...
  82. pmc EDA signaling and skin appendage development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 5:2477-83. 2006
    ..For developing skin appendages, a model for tissue-specific regulation of signaling is provided by the EDA pathway, which accesses the otherwise ubiquitous NFkappaB transcription factors...
  83. ncbi Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs
    Brigitte Hammerschmidt
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Dev Biol 305:246-61. 2007
    ..Moreover, the identified molecular hierarchy offers a model for the periodic patterning of zigzag hairs mechanistically similar to mesodermal segmentation...
  84. ncbi An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution
    Abigail K Langton
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Invest Dermatol 128:1311-8. 2008
    ..JID Journal Club article: for questions, answers, and open discussion about this article please go to http://network.nature.com/group/jidclub...
  85. doi Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation
    Katja Närhi
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 135:1019-28. 2008
    ..of beta-catenin resulted in precocious and excessive induction of hair follicles even in the absence of Eda/Edar signaling, a pathway essential for primary hair placode formation...
  86. doi Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes
    Ingrid Fliniaux
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 320:60-71. 2008
    ..Ectodysplasin-A1 (Eda-A1) and Wnts are high in hierarchy of placode activators...
  87. pmc Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice
    Diana Esibizione
    Laboratory of Genetics, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
    Gene 427:42-6. 2008
    ..earlier used expression profiling to infer genes differentially expressed at various developmental time points in Tabby (Eda-deficient) compared to wild-type mouse skin...
  88. pmc Requirement for Shh and Fox family genes at different stages in sweat gland development
    Makoto Kunisada
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, MD 21224, USA
    Hum Mol Genet 18:1769-78. 2009
    ..To initiate analyses, we compared the model of Eda mutant Tabby mice, in which sweat glands were not formed, with wild-type (WT) mice...
  89. pmc Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction
    Yuhang Zhang
    Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 17:49-61. 2009
    ..Wnt/beta-catenin signaling is initially activated independently of EDA/EDAR/NF-kappaB activity in primary hair follicle primordia...
  90. pmc Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e10009. 2010
    ..Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda(-/y)) mice still make secondary hair...
  91. ncbi A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1
    G F Kay
    Section of Comparative Biology, MRC Clinical Research Centre, Harrow, UK
    Nature 354:486-9. 1991
    ..These Y-linked genes may form part of a coregulated group of genes which function during spermatogenesis...
  92. pmc Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosome
    J Nasir
    Department of Biochemistry and Molecular Genetics, Saint Mary s Hospital Medical School, London, United Kingdom
    Proc Natl Acad Sci U S A 87:399-403. 1990
    ..First, the repeat sequence island encompasses a 1-megabase region devoid of CpG islands; second, it features a high concentration of L1 long interspersed repeat sequences...
  93. pmc Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse cross
    L C Amar
    EMBO J 4:3695-700. 1985
    ..and SPE/Pas mouse strains segregating the X chromosome markers hypoxanthine phosphoribosyl transferase (Hprt) and Tabby (Ta). Three of the probes map to the region between the centromere and Hprt, and two distal to Ta...
  94. ncbi The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus
    J P DiSanto
    INSERM U132, Hopital Necker Enfants Malades, Institut Pasteur, Paris, France
    Eur J Immunol 24:3014-8. 1994
    ..Genomic clones for the murine IL-2R gamma will allow for further studies on the regulation and function of this gene in vivo...
  95. ncbi Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 2. Follicle morphogenesis in the hair mutants, Tabby and downy
    U Vielkind
    Department of Biomedical Sciences, University of Guelph, Ont, Canada
    Acta Anat (Basel) 157:183-94. 1996
    Wild-type mice have three main types of hair in their pelage: tylotrichs, awls and zigzags. Tabby mice have a yellowish coat consisting of awls only, whereas downy mice have a sparse grayish coat consisting of unusually fine hairs...
  96. ncbi Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryos
    R V Jamieson
    Embryology Unit, Children s Medical Research Institute, Wentworthville, New South Wales, Australia
    Dev Biol 199:235-44. 1998
    ....
  97. ncbi Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
    C D Vulpe
    Howard Hughes Medical Institute and the Department of Medicine, University of California at San Francisco, 94143, USA
    Nat Genet 21:195-9. 1999
    ..We suggest that the hephaestin protein is a multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation and that it is an important link between copper and iron metabolism in mammals...
  98. ncbi Androgens indirectly accelerate thymocyte apoptosis
    G J Dulos
    Department of Pharmacology, N V Organon, Oss, The Netherlands
    Int Immunopharmacol 1:321-8. 2001
    ..Thus, it is concluded that androgens indirectly accelerate thymocyte apoptosis in vivo...
  99. ncbi Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis
    Thomas Aberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 270:76-93. 2004
    ..We conclude that Runx2 mediates the functions of epithelial FGF signals regulating Fgf3 expression in the dental mesenchyme and that Fgf3 may be a direct target gene of Runx2...
  100. ncbi NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth
    Ruth Schmidt-Ullrich
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Development 133:1045-57. 2006
    ..Furthermore, the similarity between the phenotypes of c(IkappaBADeltaN) mice and mice deficient in Eda A1 (tabby) or its receptor EdaR (downless) raised the issue of whether in vivo NF-kappaB regulates or is regulated by ..

Research Grants2

  1. Controlling Apoptosis in Oligondendrocytes
    Pamela Knapp; Fiscal Year: 2005
    ..Specific Aim 4: Biochemical and histological techniques are used to determine whether pathways which are independent of caspase-3 play a significant role in cell loss after SCI. ..
  2. Opioids Modulate Oligodendrocyte Development & Function
    Pamela Knapp; Fiscal Year: 2006
    ..Techniques used include cell culture, immunostaining, in situ hybridization, immunoblot, confocal microscopy and adenoviral transfection. ..