Dmtn

Summary

Gene Symbol: Dmtn
Description: dematin actin binding protein
Alias: AI325486, Epb4.9, Epb49, dematin, dematin, dematin actin-binding protein, erythrocyte membrane protein band 4.9, erythrocyte protein band 4.9
Species: mouse

Top Publications

  1. ncbi Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brain
    N Malgaretti
    Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute HSR, I 20132 Milan, Italy
    J Biol Chem 272:17632-9. 1997
  2. pmc Headpiece domain of dematin regulates calcium mobilization and signaling in platelets
    Adam J Wieschhaus
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 287:41218-31. 2012
  3. pmc Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3
    Marco Lalle
    Dipartimento di Malattie Infettive, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Biol Chem 286:1227-36. 2011
  4. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
  5. pmc The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation
    Morvarid Mohseni
    Department of Pharmacology, UIC Cancer Center, University of Illinois College of Medicine, Chicago, IL 60612 3725, USA
    Mol Cell Biol 28:4712-8. 2008
  6. doi Erythrocyte dematin is a candidate gene for Marie Unna hereditary hypotrichosis and related hairloss disorders
    Morvarid Mohseni
    Am J Hematol 83:430-2. 2008
  7. ncbi Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia
    Huiqing Chen
    Department of Pharmacology Cancer Center, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 282:4124-35. 2007
  8. pmc The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability
    Roy Drissen
    Erasmus MC, Department of Cell Biology, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 25:5205-14. 2005
  9. pmc Headpiece domain of dematin is required for the stability of the erythrocyte membrane
    Richie Khanna
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Proc Natl Acad Sci U S A 99:6637-42. 2002
  10. ncbi cDNA sequence, genomic structure, and expression of the mouse dematin gene (Epb4.9)
    A C Azim
    Section of Hematology Oncology Research, Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Mamm Genome 10:1026-9. 1999

Detail Information

Publications15

  1. ncbi Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brain
    N Malgaretti
    Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute HSR, I 20132 Milan, Italy
    J Biol Chem 272:17632-9. 1997
    ....
  2. pmc Headpiece domain of dematin regulates calcium mobilization and signaling in platelets
    Adam J Wieschhaus
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 287:41218-31. 2012
    b>Dematin is a broadly expressed membrane cytoskeletal protein that has been well characterized in erythrocytes and to a lesser extent in non-erythroid cells. However, dematin's function in platelets is not known...
  3. pmc Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3
    Marco Lalle
    Dipartimento di Malattie Infettive, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Biol Chem 286:1227-36. 2011
    ..Here, we show that the remodeling of the host cell directed by the parasite also includes the recruitment of dematin, an actin-binding protein of the erythrocyte membrane skeleton and its repositioning to the parasite...
  4. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  5. pmc The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation
    Morvarid Mohseni
    Department of Pharmacology, UIC Cancer Center, University of Illinois College of Medicine, Chicago, IL 60612 3725, USA
    Mol Cell Biol 28:4712-8. 2008
    ..Here, we provide the first evidence that dematin functions upstream of RhoA and regulates its activation...
  6. doi Erythrocyte dematin is a candidate gene for Marie Unna hereditary hypotrichosis and related hairloss disorders
    Morvarid Mohseni
    Am J Hematol 83:430-2. 2008
  7. ncbi Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia
    Huiqing Chen
    Department of Pharmacology Cancer Center, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 282:4124-35. 2007
    b>Dematin and adducin are actin-binding proteins of the erythrocyte "junctional complex." Individually, they exert modest effects on erythrocyte shape and membrane stability, and their homologues are expressed widely in non-erythroid cells...
  8. pmc The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability
    Roy Drissen
    Erasmus MC, Department of Cell Biology, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 25:5205-14. 2005
    ..Our data provide an explanation for the hitherto unexplained severity of the EKLF null phenotype in erythropoiesis...
  9. pmc Headpiece domain of dematin is required for the stability of the erythrocyte membrane
    Richie Khanna
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Proc Natl Acad Sci U S A 99:6637-42. 2002
    b>Dematin is an actin-binding and bundling protein of the erythrocyte membrane skeleton. Dematin is localized to the spectrin-actin junctions, and its actin-bundling activity is regulated by phosphorylation of cAMP-dependent protein kinase...
  10. ncbi cDNA sequence, genomic structure, and expression of the mouse dematin gene (Epb4.9)
    A C Azim
    Section of Hematology Oncology Research, Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Mamm Genome 10:1026-9. 1999
  11. ncbi Genomic structure, mapping, activity and expression of fibroblast growth factor 17
    J Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Dev 83:165-78. 1999
    ..In the developing great vessels Fgfl7 is preferentially expressed, suggesting that it may have a more prominent role in vascular growth...
  12. ncbi Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14
    S Strehl
    Genetics Division, Children s Hospital and Harvard Medical School, Boston, Massachusetts, 02215, USA
    Genomics 53:81-9. 1998
    ..The differences in the genomic structure of cadherin subfamilies will be discussed in the context of the evolution of the cadherin superfamily...
  13. ncbi ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis
    G A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Endocrinology 138:4262-72. 1997
    ..Finally, chromosomal mapping demonstrated that the ADAM7 gene maps to the central region of mouse Chromosome 14, approximately 4-5 cM distal from the fertilin beta locus, which encodes another reproductive-specific ADAM protein...
  14. ncbi Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion
    C Cho
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut, 06030, USA
    Genomics 34:413-7. 1996
    ....
  15. ncbi The gene encoding the erythrocyte membrane skeleton protein dematin (Epb4.9) maps to mouse chromosome 14
    L L Peters
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 26:634-5. 1995