Dlx1

Summary

Gene Symbol: Dlx1
Description: distal-less homeobox 1
Alias: Dlx, Dlx-1, homeobox protein DLX-1, DII B
Species: mouse

Top Publications

  1. ncbi Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes
    S A Anderson
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94143 0984, USA
    Science 278:474-6. 1997
  2. ncbi Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina
    Jimmy de Melo
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
    Development 132:311-22. 2005
  3. pmc A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
  4. ncbi Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
    A Bulfone
    Department of Psychiatry, University of California, San Francisco 94143 0984
    J Neurosci 13:3155-72. 1993
  5. ncbi Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone
    Marie Catherine Tiveron
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
    J Neurosci 26:13273-8. 2006
  6. ncbi Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb development
    P Dolle
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Differentiation 49:93-9. 1992
  7. ncbi Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres
    S Xuan
    Cell Biology and Genetics Program, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Neuron 14:1141-52. 1995
  8. ncbi Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system
    S Garel
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Dev Dyn 210:191-205. 1997
  9. ncbi Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition
    B L Thomas
    Department of Craniofacial Development, Guy s Hospital, London, UK
    Development 124:4811-8. 1997
  10. ncbi Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain
    M Qiu
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco 94143 0984, USA
    Genes Dev 9:2523-38. 1995

Research Grants

Scientific Experts

  • L Puelles
  • Yangu Zhao
  • Juhee Jeong
  • GRANT STEPHEN MASTICK
  • Gregory B Potter
  • Kathryn Markham
  • Kunio Kitamura
  • Yanling Wang
  • Gordon Fishell
  • Zhiyong Zhao
  • R Maas
  • Inma Cobos
  • S R Line
  • R F Hevner
  • A Stoykova
  • H Toresson
  • C P Simmons
  • H Peters
  • F Lezot
  • John L R Rubenstein
  • Jason E Long
  • Noel Ghanem
  • J L Rubenstein
  • Marc Ekker
  • Jimmy de Melo
  • S A Anderson
  • Guoyan Du
  • David D Eisenstat
  • Vincent Villette
  • Gary Hatch
  • A Bulfone
  • Mario Fonseca
  • Shyamali Mandal
  • Petra Kraus
  • Hae Young Lee
  • Qing Ping Zhou
  • Gary T Philips
  • Amelia Stanco
  • Thomas Lufkin
  • Bryan A Seybold
  • O Marin
  • Hiroki Taniguchi
  • Yong Ri Jin
  • Bei Wang
  • Sonia Garel
  • Vanessa Coremans
  • Angela Bithell
  • Koji Oishi
  • M Qiu
  • Gaia Colasante
  • Harold Cremer
  • Nadia Lo Iacono
  • Feng Qiu
  • Francois Guillemot
  • Kazuaki Yoshikawa
  • Luc Poitras
  • Sophie Chauvet
  • Arturo Alvarez-Buylla
  • Minoree Kohwi
  • Trung N Le
  • Giovanni Levi
  • Olivier Britz
  • Daniel B Polley
  • S Garel
  • D D Eisenstat
  • Marie Catherine Tiveron
  • Marjory L Givens
  • Carrie N Stair
  • Olga Britanova
  • Wei Liu
  • Kenryo Furushima
  • Ling Pan
  • Christopher Gregg
  • Emily Wroblewski
  • Antigoni Ekonomou
  • Nadean L Brown
  • J K Liu
  • Y Suda
  • Noriko Osumi
  • Shinichi Aizawa
  • C Fode
  • Hiroshi Kiyonari
  • Daisuke Kurokawa
  • Andrea Faedo
  • Louis Bruno Ruest
  • S Casarosa
  • Xiangguo Qiu
  • Agnes Baude
  • Philippe Lachamp
  • Gracie L Andrews

Detail Information

Publications104 found, 100 shown here

  1. ncbi Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes
    S A Anderson
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94143 0984, USA
    Science 278:474-6. 1997
    ..Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few ..
  2. ncbi Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina
    Jimmy de Melo
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
    Development 132:311-22. 2005
    ..Expression begins at embryonic day 12.5 and is maintained until late embryogenesis for Dlx1, while Dlx2 expression extends to adulthood...
  3. pmc A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
    ..Our results suggest that some OB interneurons are derived from progenitors outside the LGE and that precursors expressing what has classically been considered a pallial transcription factor generate GABAergic interneurons...
  4. ncbi Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
    A Bulfone
    Department of Psychiatry, University of California, San Francisco 94143 0984
    J Neurosci 13:3155-72. 1993
    ..5 mouse embryo. Three of the genes, Dlx-1, Dlx-2 (Tes-1), and Gbx-2, encode homeodomain-containing proteins, and one gene, Wnt-3, encodes a putative ..
  5. ncbi Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone
    Marie Catherine Tiveron
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
    J Neurosci 26:13273-8. 2006
    ..Using MASH-1 mutant mice in concert with the interneuron marker DLX, we exclude that interneurons themselves produce the chemokine in an autocrine manner...
  6. ncbi Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb development
    P Dolle
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Differentiation 49:93-9. 1992
    We have analysed the expression pattern of the mouse homeobox containing gene Dlx-1. This gene harbors a homeodomain related to that found in the Drosophila distal-less (dll) gene...
  7. ncbi Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres
    S Xuan
    Cell Biology and Genetics Program, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Neuron 14:1141-52. 1995
    ..These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation...
  8. ncbi Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system
    S Garel
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Dev Dyn 210:191-205. 1997
    ..These data suggest that Ebf genes may be involved in the control of neuronal differentiation in the CNS and in enforcing regional diversity in populations of post-mitotic forebrain neurons...
  9. ncbi Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition
    B L Thomas
    Department of Craniofacial Development, Guy s Hospital, London, UK
    Development 124:4811-8. 1997
    ..A role for Dlx-1 and Dlx-2 genes in patterning of the dentition has been proposed with the genes envisaged as participating in an '..
  10. ncbi Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain
    M Qiu
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco 94143 0984, USA
    Genes Dev 9:2523-38. 1995
    ..To determine the function of Dlx-2, we generated a null mutation in mice using gene targeting...
  11. pmc Cloning and characterization of two members of the vertebrate Dlx gene family
    A Simeone
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    Proc Natl Acad Sci U S A 91:2250-4. 1994
    ..Similarly, the two human genes DLX1 and DLX2 are closely linked in a convergent configuration at 2q32, near the HOXD (previously HOX4) locus...
  12. ncbi Forebrain patterning defects in Small eye mutant mice
    A Stoykova
    Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 122:3453-65. 1996
    ..Our detailed analysis included a comparison of the expression of Pax6, Dlx1 and several other genes during embryonic mouse brain development in wild-type and in the mutant Small eye (Sey) ..
  13. ncbi Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches
    M Qiu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Biol 185:165-84. 1997
    The Dlx homeobox gene family is expressed in a complex pattern within the embryonic craniofacial ectoderm and ectomesenchyme...
  14. ncbi Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons
    S A Anderson
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
    Neuron 19:27-37. 1997
    ..Inroads to this subject have been made, due to the discovery of transcription factors, such as the Dlx genes, whose expression patterns suggest that they have a role in striatal development...
  15. ncbi Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation
    J K Liu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Dyn 210:498-512. 1997
    The Dlx gene family encodes homeodomain proteins that are required for forebrain and craniofacial development...
  16. ncbi Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes
    A S Fernandez
    CNRS URA 1414, Equipe Régionalisation nerveuse, Ecole Normale Superieure, 46, rue d Ulm 75230 PARIS Cedex 05 France
    Development 125:2099-111. 1998
    ..Expression of homeobox-containing genes of the Emx, Dlx and Pax families were used as markers of anteroposterior developmental subdivisions of the forebrain in mouse, ..
  17. ncbi Mash1 regulates neurogenesis in the ventral telencephalon
    S Casarosa
    IGBMC, CNRS INSERM Universite Louis Pasteur, BP 163, CU de Strasbourg, France
    Development 126:525-34. 1999
    ..Therefore, Mash1 is an important regulator of neurogenesis in the ventral telencephalon, where it is required both to specify neuronal precursors and to control the timing of their production...
  18. ncbi An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons
    A Bulfone
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Neuron 21:1273-82. 1998
    ..with a homozygous deficiency in Tbr-1 lack most projection neurons, whereas mice with a homozygous deficiency in Dlx-1 and Dlx-2 lack most GABAergic interneurons...
  19. ncbi DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
    D D Eisenstat
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
    J Comp Neurol 414:217-37. 1999
    The homeobox genes in the Dlx family are required for differentiation of basal forebrain neurons and craniofacial morphogenesis...
  20. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
    Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns...
  21. ncbi Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Development 127:4361-71. 2000
    ..identity of early striatal progenitors and in its absence the ventral telencephalic regulatory genes Mash1 and Dlx are lost from most of the striatal germinal zone...
  22. ncbi The Gsh2 homeodomain gene controls multiple aspects of telencephalic development
    J G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 127:5007-20. 2000
    ..Taken together, our data support a model in which Gsh2, in response to sonic hedgehog signaling, plays a crucial role in multiple aspects of telencephalic development...
  23. ncbi Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
    K Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, Box 0984, San Francisco, CA 94143 0984, USA
    Development 128:193-205. 2001
    ..The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system...
  24. ncbi Distinct cortical migrations from the medial and lateral ganglionic eminences
    S A Anderson
    Nina Ireland Laboratory of Developmental Neuroscience, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Development 128:353-63. 2001
    ..In addition, by comparing the phenotypes of mouse mutants with differential effects on MGE and LGE migration, we provide evidence that the MGE and LGE may give rise to different subtypes of cortical interneurons...
  25. ncbi Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons
    S J Pleasure
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neuron 28:727-40. 2000
    ..differentiation in the embryonic basal telencephalon (lateral and medial ganglionic eminences) through loss of Dlx1/2 homeobox function blocks the migration of virtually all GABAergic interneurons to the hippocampus...
  26. ncbi Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions
    O Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, CA 94143, USA
    Science 293:872-5. 2001
    ....
  27. ncbi Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans
    Kunio Kitamura
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Nat Genet 32:359-69. 2002
    ..The present report is, to our knowledge, the first to use phenotypic analysis of a knockout mouse to identify a gene associated with an X-linked human brain malformation...
  28. pmc Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters
    Noel Ghanem
    Ottawa Health Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Genome Res 13:533-43. 2003
    Dlx homeobox genes of vertebrates are generally arranged as three bigene clusters on distinct chromosomes. The Dlx1/Dlx2, Dlx5/Dlx6, and Dlx3/Dlx7 clusters likely originate from duplications of an ancestral Dlx gene pair...
  29. ncbi Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina
    Jimmy de Melo
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
    J Comp Neurol 461:187-204. 2003
    ..We assessed Dlx gene expression in the developing and adult mouse retina. Dlx1 and Dlx2 are detected in retinal neuroprogenitors by embryonic day (E) 12.5 (Eisenstat et al. [1999] J. Comp...
  30. pmc Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation
    Qing Ping Zhou
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
    Nucleic Acids Res 32:884-92. 2004
    ..Dlx genes are expressed in the developing forebrain, retina, craniofacial structures and limbs. Dlx1/Dlx2 double knockout mice die at birth with multiple defects including abnormal forebrain development and decreased ..
  31. ncbi The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158 2611, USA
    J Comp Neurol 483:292-303. 2005
    ..functionally relevant role in regulating Arx in vivo, as shown by the severe reduction in the expression of Arx in Dlx1/2 double-knockout mice...
  32. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Here we show that Dlx1 is also required for regulating the functional longevity of cortical and hippocampal interneurons in the adult ..
  33. ncbi Cellular patterns of transcription factor expression in developing cortical interneurons
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
    Cereb Cortex 16:i82-8. 2006
    ..patterns in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB)...
  34. ncbi Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2
    Trung N Le
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
    J Biol Chem 282:19071-81. 2007
    Dlx homeobox genes play an important role in vertebrate forebrain development. Dlx1/Dlx2 null mice die at birth with an abnormal cortical phenotype, including impaired differentiation and migration of GABAergic interneurons to the ..
  35. pmc Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:3230-43. 2007
    ..Here we explore the mechanisms that result in olfactory bulb interneuron defects in Dlx1&2-/- (distal-less homeobox 1 and 2) and Mash1-/- (mammalian achaete-schute homolog 1) mutants...
  36. ncbi The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer
    Luc Poitras
    Center for Advanced Research in Environmental Genomics CAREG Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Development 134:1755-65. 2007
    ..In the developing forebrain of mammals, the combined function of the Dlx1, Dlx2, Dlx5 and Dlx6 homeobox genes is necessary for the differentiation of the GABAergic interneurons born in the ..
  37. pmc Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons
    Noel Ghanem
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 27:5012-22. 2007
    ..These data suggest that interneuron subtypes use distinct combinations of Dlx1/Dlx2 enhancers from the time they are specified through adulthood.
  38. pmc Dlx transcription factors promote migration through repression of axon and dendrite growth
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 54:873-88. 2007
    ..However, the mechanisms underlying this process are poorly understood. Here, we demonstrate that Dlx1/2 has a central role in restraining neurite growth of subpallial-derived immature interneurons at a stage when they ..
  39. pmc Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons
    Gregory B Potter
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
    Mol Cell Neurosci 40:167-86. 2009
    b>DLX1 and DLX2 transcription factors are necessary for forebrain GABAergic neuron differentiation, migration, and survival...
  40. pmc Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways
    Jason E Long
    Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, CA 94158 2324, USA
    Cereb Cortex 19:i96-106. 2009
    ..We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most gamma-aminobutyric acidergic projection neurons ..
  41. pmc CXCR4 and CXCR7 have distinct functions in regulating interneuron migration
    Yanling Wang
    Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Neuron 69:61-76. 2011
    ..On the other hand, CXCL12 stimulation of CXCR7, but not CXCR4, promoted MAP kinase signaling. Thus, we suggest that CXCR4 and CXCR7 have distinct roles and signal transduction in regulating interneuron movement and laminar positioning...
  42. pmc A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
    Hiroki Taniguchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 71:995-1013. 2011
    ..As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain...
  43. ncbi Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus
    T McGuinness
    Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco 94143 0984, USA
    Genomics 35:473-85. 1996
    There are at least five murine Dlx genes that are related to the Drosophila Distal-less homeobox gene...
  44. ncbi Dlx-1 and Dlx-2 expression in the adult mouse brain: relationship to dopaminergic phenotypic regulation
    Sachiko Saino-Saito
    Weill Medical College of Cornell University at The Burke Medical Research Institute, White Plains, New York 10605, USA
    J Comp Neurol 461:18-30. 2003
    Expression of the homeodomain-containing transcription factors Dlx-1 and Dlx-2 in the lateral (LGE) and medial (MGE) ganglionic eminences, subpallial embryonic structures, is required for generation of telencephalic interneurons...
  45. pmc Multiple requirements for Hes 1 during early eye formation
    Hae Young Lee
    Department of Pediatrics, Northwestern University Medical School at Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    Dev Biol 284:464-78. 2005
    ..Together, these studies demonstrate that Hes1, like Pax6, simultaneously regulates multiple developmental processes during optic development...
  46. pmc Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development
    Sophie Chauvet
    Developmental Biology Institute of Marseille Luminy, CNRS UMR 6216, University of Mediterranee, Case 907, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Neuron 56:807-22. 2007
    ..Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits...
  47. ncbi Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system
    K H Kaestner
    Division of Molecular Biology of the Cell I, German Cancer Research Centre, Heidelberg, Germany
    Mech Dev 55:221-30. 1996
    ..5 centiMorgans (cM) and fkh-4 to chromosome 19 at 10.5 cM. The potential relationship of the two genes to the mouse mutations staggerer and small thymus (for fkh-5) and muscle deficient (for fkh-4) is discussed...
  48. ncbi Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway
    E S Monuki
    Division of Neurogenetics, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuron 32:591-604. 2001
    ..These findings provide evidence for the roof plate as an organizing center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning...
  49. pmc Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity
    Louis Bruno Ruest
    Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY 40292, USA
    Development 131:4413-23. 2004
    ..Together, our results suggest that the establishment of a 'mandibular identity' during lower jaw development requires both Ednra-dependent and -independent signaling pathways...
  50. pmc Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder
    Angela Bithell
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 5:e10392. 2010
    In the rodent forebrain GABAergic neurons are generated from progenitor cells that express the transcription factors Dlx1 and Dlx2...
  51. doi The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster
    Noel Ghanem
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Neurosci 32:8219-30. 2012
    ..show that the Rb/E2F pathway regulates key aspects of differentiation and migration through direct control of the Dlx1 and Dlx2 homeodomain proteins, required for interneuron specification...
  52. pmc Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex
    Bryan A Seybold
    Coleman Memorial Laboratory, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 109:13829-34. 2012
    ..cortical inhibitory interneurons after the critical period by studying mice with a conditional deletion of Dlx1. Following the loss of interneurons, baseline firing rates rose and tone-evoked responses became less sparse in ..
  53. ncbi Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall
    S J Gaunt
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Development 117:769-78. 1993
    ..Our findings lead us to suggest that the goosecoid gene product plays a role in spatial programming within discrete embryonic fields, and possibly lineage compartments, during organogenesis stages of mouse development...
  54. ncbi Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Development 125:813-24. 1998
    ..These observations define a novel genetic pathway for inductive communication between cephalic neural crest cells and their environmental counterparts...
  55. ncbi The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice
    Sonia Garel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143 0984, USA
    Development 129:5621-34. 2002
    ..A similar shift in the topography of thalamocortical axons inside the basal ganglia and neocortex was observed in Dlx1/2(-/-) embryos, which also have an abnormal basal ganglia development...
  56. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
    ..By contrast, we continue to postulate that prosomeres p1-p3 (i.e. the pretectum, thalamus and prethalamus) are the caudal forebrain...
  57. pmc Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type
    Gary T Philips
    Biology Department, University of Nevada, Biology 200, 1664 N Virginia Street, Reno, NV 89557, USA
    Dev Biol 279:308-21. 2005
    ..Subsequently, precocious neurons adopted a generic rather than a specific retinal neuron fate. Thus, Pax6 regulates the timing of retinal neurogenesis and couples it with specific neuron differentiation programs...
  58. pmc Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1
    Antigoni Ekonomou
    Mammalian Neurogenesis Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kingdom
    PLoS Biol 3:e186. 2005
    ..Our data also suggest that other SOXB1 members showing expression in specific neuronal populations are likely to play continuous roles from the establishment of precursors to their final differentiation...
  59. doi Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects
    Nadia Lo Iacono
    Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
    Development 135:1377-88. 2008
    ..Here, we show that p63 and Dlx proteins colocalize in the nuclei of the apical ectodermal ridge (AER)...
  60. pmc Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons
    Gaia Colasante
    Department of Biological and Technological Research, San Raffaele Scientific Institute, Stem Cell Research Institute, Vita e Salute San Raffaele University, 20132 Milan, Italy
    J Neurosci 28:10674-86. 2008
    ..Functional characterization of the Arx GABAergic enhancer element revealed its strict dependence on the activity of Dlx transcription factors...
  61. pmc Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin
    Vanessa Coremans
    KU Leuven, VIB Vesalius Research Center, Herestraat 49, Gasthuisberg O and N1, B3000 Leuven, Belgium
    BMC Neurosci 11:2. 2010
    ..Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated...
  62. pmc Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons
    Shyamali Mandal
    Department of Psychiatry, Neuroscience Program and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, California 94158 2324, Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, and Cold Spring Harbor Laboratories, Laurel Hollow, New York 11791
    J Neurosci 33:16897-914. 2013
    ..b>Dlx1/2(-/-) and Lhx6(-/-) mouse mutants, which exhibit MGE interneuron migration defects, have reduced expression of the ..
  63. pmc Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood
    Vincent Villette
    INSERM U901, Marseille, 13009, France
    J Comp Neurol 524:2440-61. 2016
    ..We propose that a subpopulation of EBGNs forms into adulthood a scaffold of GABAergic projection neurons linking the hippocampus to distant structures. J. Comp. Neurol. 524:2440-2461, 2016. © 2016 Wiley Periodicals, Inc. ..
  64. pmc Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala
    Bei Wang
    Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, California 94158 2324, USA
    J Comp Neurol 519:2320-34. 2011
    ..expression from the Dlx6-lacZ (Dlx6(LacZ) ) allele in heterozygotes (Dlx6(LacZ/+) ), with the expression of Dlx1, Dlx2, Dlx5 and Dlx6 RNA...
  65. doi Making sense of Dlx1 antisense RNA
    Petra Kraus
    Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore 138672, Singapore
    Dev Biol 376:224-35. 2013
    ..to interrogate the biological significance of another distal-less antisense lncRNA, the previously uncharacterized Dlx1 antisense (Dlx1as) transcript...
  66. ncbi Order of six loci at 2q24-q31 and orientation of the HOXD locus
    E Rossi
    Universita di Pavia, Italy
    Genomics 24:34-40. 1994
    ..of 9 homeobox genes of the Antennapedia class; EVX2, a homeobox gene related to Drosophila-even-skipped gene; DLX1 and DLX2, two homeobox genes related to the Drosophila distal-less gene; and TTN and NEB, the genes for the two ..
  67. pmc A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    EMBO J 12:2735-47. 1993
    ..Its gene product contains a homeodomain of the bicoid class and is able to recognize and transactivate a bicoid target sequence...
  68. ncbi Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain
    M Hallonet
    Max Planck Institut for Biophysical Chemistry, Department of Molecular and Cell Biology, Am Fassberg 11, Germany
    Development 125:2599-610. 1998
    ..Comparison of the limits of the expression territory of Vax1 with that of Dlx1, Pax6 and Emx1 indicates that the corticostriatal ridge is a complex structure with distinct identifiable genetic ..
  69. ncbi FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development
    M Bei
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 125:4325-33. 1998
    ..In addition, we have investigated the effects of FGFs and BMP4 on the distal-less homeobox genes Dlx1 and Dlx2 and we have clarified the relationship between Msx and Dlx gene function in the developing tooth...
  70. ncbi Ebf1 controls early cell differentiation in the embryonic striatum
    S Garel
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 126:5285-94. 1999
    ....
  71. pmc Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene
    D Acampora
    International Institute of Genetics and Biophysics, Consiglio Nationale delle Ricerche CNR, 80125 Naples, Italy
    Genes Dev 13:2787-800. 1999
    ....
  72. ncbi MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants
    C P Simmons
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, United Kingdom
    J Immunol 163:6502-10. 1999
    ..The results highlight the versatility of toxin-based adjuvants and suggest that LT potentiates CTL responses independently of IL-12 and IFN-gamma and probably by a mechanism unrelated to cross-priming...
  73. ncbi Pax6 regulates the identity of embryonic diencephalic neurons
    G S Mastick
    Department of Biology, University of Nevada, Reno, Nevada 89557, USA
    Mol Cell Neurosci 17:190-207. 2001
    ..2, and a subset of proliferating progenitors were labeled with an antibody against DLX transcription factors...
  74. ncbi Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression
    Thorsten Stühmer
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Development 129:245-52. 2002
    ..We also used this method to show cross-regulation between different Dlx family members. We find that Dlx2 can induce Dlx5 expression, and that Dlx1, Dlx2 and Dlx5 can induce expression from a Dlx5/6-lacZ enhancer/"reporter construct.
  75. ncbi Mosaic development of the olfactory cortex with Pax6-dependent and -independent components
    Tatsumi Hirata
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
    Brain Res Dev Brain Res 136:17-26. 2002
    ....
  76. ncbi Cross-talk between Msx/Dlx homeobox genes and vitamin D during tooth mineralization
    F Lezot
    Laboratoire de Biologie Orofaciale et Pathologie INSERM EMI 0110, Université Paris 7 EA2380, IFR 58 Institut des Cordeliers, rue de l Ecole de Medecine, 75006 Paris, France
    Connect Tissue Res 43:509-14. 2002
    ..This study is devoted to potential cross-talk between vitamin D and Msx/Dlx transcription factors...
  77. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
  78. ncbi Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon
    Jan Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    Development 130:1113-22. 2003
    ..This correlates well with the malformation of the lateral and basolateral amygdala in Tlx mutants, both of which have been suggested to derive from ventral portions of the pallium...
  79. ncbi A role for the mesenchymal T-box gene Brachyury in AER formation during limb development
    Chunqiao Liu
    Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Development 130:1327-37. 2003
    ....
  80. ncbi Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial origin
    Robert F Hevner
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359630, 325 Ninth Ave, Seattle, WA 98104 2499, USA
    Brain Res Dev Brain Res 141:39-53. 2003
    ..5. In contrast, interneurons expressed a subpallial transcription factor (Dlx), contained high levels of GABA, were frequently calbindin(+), and were born throughout corticogenesis (from E10...
  81. ncbi Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm
    Daisuke Kurokawa
    Laboratory for Vertebrate Body Plan, Center for Developmental Biology CDB RIKEN Kobe, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0046, Japan
    Development 131:3307-17. 2004
    ..The AN enhancer region is conserved among mouse, human and Xenopus; moreover, the counterpart region in Xenopus exhibited an enhancer activity in mouse anterior neuroectoderm...
  82. ncbi CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain
    Christopher Gregg
    Genes and Development Research Group, Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Development 132:565-78. 2005
    ..These results demonstrate a novel region-specific role for CNTF/LIF/gp130 signaling in the development of the germinal layers of the embryonic telencephalon...
  83. ncbi Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis
    Ling Pan
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 132:703-12. 2005
    ..These results indicate that Brn3 factors are functionally equal and that their unique roles in neurogenesis are determined by the distinctive Brn3 spatiotemporal expression patterns...
  84. ncbi Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
    Eur J Neurosci 21:658-68. 2005
    ..In the Lbx1 mutants Satb2 expression is greatly reduced. We suggest that Satb2 may regulate differentiation of subsets of neurons at the level of higher order chromatin structure via binding to MARs...
  85. ncbi Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain
    Kenryo Furushima
    Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology CDB, RIKEN Kobe, Kobe, Japan
    Dev Dyn 232:1056-61. 2005
    ..However, no defects were apparent in embryonic day 10.5 Opr null mutants, and subtle defects were later found in medial pallium and ventral structures of forebrain, suggesting the compensation of Opr deficiency by its cognate(s)...
  86. pmc Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families
    Marjory L Givens
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093 0674, USA
    J Biol Chem 280:19156-65. 2005
    ..Finally, mice lacking MSX1 or DLX1 and 2 show altered numbers of GnRH-expressing cells in regions where these factors likely function...
  87. ncbi Severe hearing loss in Dlxl mutant mice
    Daniel B Polley
    Coleman Memorial Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143, USA edu
    Hear Res 214:84-8. 2006
    The Dlx homeobox gene family participates in regulating middle and inner ear development...
  88. ncbi A role for proneural genes in the maturation of cortical progenitor cells
    Olivier Britz
    Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Cereb Cortex 16:i138-51. 2006
    ..Taken together, these data support a model whereby Ngn2 and Mash1 function together to regulate the zonal distribution of progenitors in the developing neocortex...
  89. pmc A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors
    Feng Qiu
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 28:3392-403. 2008
    ..Our data suggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism...
  90. pmc Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways
    Jason E Long
    Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, California 94158 2324, USA
    J Comp Neurol 512:556-72. 2009
    ..We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most GABAergic projection neurons of the basal ..
  91. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
    ..Thus, our study identifies Rspo2 as a mesenchyme-derived factor that plays critical roles in regulating BA1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate...
  92. ncbi Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain
    M Price
    European Molecular Biology Laboratory, Heidelberg, Germany
    Neuron 8:241-55. 1992
    ..abuts and partially overlaps with the expression domains of two other related homeobox-containing genes, TTF-1 and Dlx. The expression domains of the three genes in the developing prosencephalon coincide with anatomical boundaries, ..
  93. pmc The evolution of the vertebrate Dlx gene family
    D W Stock
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Proc Natl Acad Sci U S A 93:10858-63. 1996
    The vertebrate Dlx gene family consists of homeobox-containing transcription factors distributed in pairs on the same chromosomes as the Hox genes...
  94. ncbi Emx1 and Emx2 functions in development of dorsal telencephalon
    M Yoshida
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Japan
    Development 124:101-11. 1997
    ..In the more lateral region of telencephalon, Emx2-deficiency may be compensated for by Emx1 and vice versa. Phenotypes of newborn brains also suggest that these genes function in neurogenesis corresponding to their later expressions...
  95. ncbi Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate
    H Miura
    Mitsubishi Kasei Institute of Life Sciences, Machida shi, Tokyo, Japan
    Mech Dev 65:99-109. 1997
    ..The expression of Arx in the ganglionic eminence and ventral thalamus overlapped regionally with that of Dlx1, but the cell layer where Arx is expressed differed from that of the Dlx1...
  96. pmc A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
    ....
  97. ncbi Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence
    C Skogh
    Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Mol Cell Neurosci 17:811-20. 2001
    ..These results demonstrate that at least a subpopulation of neurogenic LGE precursors exhibit glial characteristics...
  98. ncbi Emx2 directs the development of diencephalon in cooperation with Otx2
    Y Suda
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University, Japan
    Development 128:2433-50. 2001
    ..Consequently, development of the dorsal and ventral thalamus and anterior pretectum requires cooperation between Emx2 and Otx2, whereas Emx2 expression is incompatible with development of the commissural region of the pretectum...
  99. pmc Differential modulation of BMP signaling promotes the elaboration of cerebral cortical GABAergic neurons or oligodendrocytes from a common sonic hedgehog-responsive ventral forebrain progenitor species
    Shau Yu Yung
    Departments of Neuroscience, Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:16273-8. 2002
    ....
  100. ncbi Variation of tooth number in mammalian dentition: connecting genetics, development, and evolution
    Sergio R P Line
    Department of Morphology, Faculdade de Odontologia de Piracicaba, State University of Campinas, 13414 900Piracicaba SP, Brazil
    Evol Dev 5:295-304. 2003
    ....
  101. ncbi Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus
    Gracie L Andrews
    Biology and Biochemistry Departments, Cell and Molecular Biology Graduate Program, University of Nevada, Reno 89557, USA
    Mol Cell Neurosci 23:107-20. 2003
    ..for DLX function, the initial differentiation of the ventral thalamic neurons was examined in embryos mutant for Dlx1 and Dlx2...

Research Grants5

  1. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  2. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  3. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  4. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  5. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....