Dll4

Summary

Gene Symbol: Dll4
Description: delta-like 4 (Drosophila)
Alias: Delta4, delta-like protein 4, drosophila Delta homolog 4
Species: mouse

Top Publications

  1. ncbi Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras
    Philip S Hodkinson
    University of Edinburgh, MRC Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4SA, Scotland, United Kingdom
    J Biol Chem 282:28991-9001. 2007
  2. ncbi Monitoring Notch1 activity in development: evidence for a feedback regulatory loop
    Gonzalo del Monte
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Campus Cantoblanco, Madrid, Spain
    Dev Dyn 236:2594-614. 2007
  3. doi Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos
    Elizabeth A V Jones
    Inserm U833, F 75005, Paris, France
    Development 135:2479-88. 2008
  4. doi Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches
    Joanne B Tan
    Hospital for Sick Children Research Institute, Toronto, ON, Canada
    Immunity 30:254-63. 2009
  5. pmc Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches
    Mi Jeong Yoon
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, South Korea
    Mol Cell Biol 28:4794-804. 2008
  6. pmc Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
    Branden R Nelson
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Dev Dyn 238:2163-78. 2009
  7. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
  8. pmc Dll4, a novel Notch ligand expressed in arterial endothelium
    J R Shutter
    Departments of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 USA
    Genes Dev 14:1313-8. 2000
  9. pmc Notch signaling is essential for vascular morphogenesis in mice
    L T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 14:1343-52. 2000
  10. ncbi Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels
    N Villa
    Department of Biological Chemistry, UCLA, Los Angeles, CA 90095 1737, USA
    Mech Dev 108:161-4. 2001

Research Grants

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras
    Philip S Hodkinson
    University of Edinburgh, MRC Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4SA, Scotland, United Kingdom
    J Biol Chem 282:28991-9001. 2007
    ..This new CSL-independent Notch/R-Ras pathway provides a molecular mechanism to explain Notch, integrin, and Ras cross-talk during the development of multicellular organisms...
  2. ncbi Monitoring Notch1 activity in development: evidence for a feedback regulatory loop
    Gonzalo del Monte
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Campus Cantoblanco, Madrid, Spain
    Dev Dyn 236:2594-614. 2007
    ..We found that Notch1 transcription and activity was severely reduced in zebrafish and mouse Notch pathway mutants, suggesting that vertebrate Notch1 expression is regulated by a positive feedback loop...
  3. doi Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos
    Elizabeth A V Jones
    Inserm U833, F 75005, Paris, France
    Development 135:2479-88. 2008
    ..This method allows genetic defects caused by loss-of-function of a gene important for cardiovascular development to be isolated even in the presence of hemodynamic defects...
  4. doi Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches
    Joanne B Tan
    Hospital for Sick Children Research Institute, Toronto, ON, Canada
    Immunity 30:254-63. 2009
    ..Our study has revealed that the Fringe-Notch2 interaction has important functions in vivo and provides insights into mechanisms regulating MZ B cell development...
  5. pmc Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches
    Mi Jeong Yoon
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, South Korea
    Mol Cell Biol 28:4794-804. 2008
    ..Interestingly, dll1 and dll4/Jag1 are expressed in the SAPs and the endothelium of the AGM, respectively, where mib1 is detected...
  6. pmc Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
    Branden R Nelson
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Dev Dyn 238:2163-78. 2009
    ..Thus, these results suggest a molecular mechanism whereby attenuated Notch levels coupled with reduced proneurogenic activity in progenitors leads to increased gliogenesis and decreased neurogenesis in the Ascl1-deficient retina...
  7. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
    ..Notch 2 and Notch 1/3 may, therefore, have different roles in the commitment and differentiation of neuronal and glial lineages of the OE during development, and the maintenance of non-neuronal phenotypes postnatally...
  8. pmc Dll4, a novel Notch ligand expressed in arterial endothelium
    J R Shutter
    Departments of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 USA
    Genes Dev 14:1313-8. 2000
    We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular ..
  9. pmc Notch signaling is essential for vascular morphogenesis in mice
    L T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 14:1343-52. 2000
    ..Analysis of the expression patterns of genes encoding ligands for Notch family receptors indicated that only the Dll4 gene is expressed in a pattern consistent with that expected for a gene encoding a ligand for the Notch1 and Notch4 ..
  10. ncbi Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels
    N Villa
    Department of Biological Chemistry, UCLA, Los Angeles, CA 90095 1737, USA
    Mech Dev 108:161-4. 2001
    ..Here, we report that Notch1, Notch3, Notch4, Delta4, Jagged1 and Jagged2 are all expressed in arteries, but are not expressed by veins...
  11. ncbi A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer
    X Q Yan
    Department of Pathology Pharmacology, Amgen, Thousand Oaks, CA 91320, USA
    Blood 98:3793-9. 2001
    ..The biological role of a novel Notch ligand, Dll4, in mice was explored by reconstituting lethally irradiated mice with bone marrow (BM) cells transduced with Dll4 ..
  12. ncbi Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis
    C Mailhos
    Developmental Genetics, Imperial Cancer Research Fund, London, England
    Differentiation 69:135-44. 2001
    ..We report the expression of Delta4 (D14) in arterial endothelium during mouse embryogenesis and in the endothelium of tumor blood vessels...
  13. ncbi Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
    Katsuto Hozumi
    Department of Immunology, and Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Nat Immunol 5:638-44. 2004
    ..Thus, Notch signaling is essential for lymphocyte development in vivo, but there is a redundancy of Notch-Notch ligand signaling that can drive T cell development within the thymus...
  14. pmc Dosage-sensitive requirement for mouse Dll4 in artery development
    Antonio Duarte
    CIISA, Faculdade de Medicina Veterinaria, 1300 0 477 Lisboa, Portugal
    Genes Dev 18:2474-8. 2004
    ..In mice, the Notch4 receptor and the Delta-like 4 (Dll4) ligand are specifically expressed in arterial endothelial cells, suggesting a similar role...
  15. pmc Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 18:2469-73. 2004
    ..Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand exhibit haploinsufficient lethality because of defects in vascular remodeling...
  16. pmc Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    Nicholas W Gale
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 101:15949-54. 2004
    ..One potential such regulator is delta-like 4 ligand (Dll4), a recently identified partner for the Notch receptors...
  17. ncbi Periodic Delta-like 4 expression in developing retinal arteries
    Suzanne Claxton
    Department of Biology, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Gene Expr Patterns 5:123-7. 2004
    ..We studied expression of Notch 1-4 and its ligand Delta-like 4 (Dll4) in the developing retinal vasculature...
  18. ncbi Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles
    Rui Benedito
    CIISA, Faculdade de Medicina Veterinaria, R Prof Cid dos Santos, 1300 477 Lisboa, Portugal
    Gene Expr Patterns 5:750-5. 2005
    ..Here, we report the expression pattern of a Delta gene family member, Delta-like 4 (Dll4)...
  19. ncbi Three-dimensional architecture of the thymus is required to maintain delta-like expression necessary for inducing T cell development
    Mahmood Mohtashami
    Department of Immunology, University of Toronto, and Sunnybrook and Women s Research Institute, Toronto, Ontario, Canada
    J Immunol 176:730-4. 2006
    ..to fetal thymic organ cultures, TSMC fail to maintain expression of the Notch ligands, Delta-like (Dll) 1 and Dll4, and concomitantly lose the ability to support T lymphopoiesis...
  20. ncbi Delta-4 Notch ligand promotes erythroid differentiation of human umbilical cord blood CD34+ cells
    Akira Sugimoto
    Hayashibara Biochemical Laboratories, Inc Okayama, Japan
    Exp Hematol 34:424-32. 2006
    ..In this study, we analyzed effects of one Notch ligand, Delta-4, whose function is less clear than others, such as Delta-1 and Jagged-1 and -2...
  21. ncbi The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development
    Seungwoon Seo
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Dev Biol 294:458-70. 2006
    ..of Foxc genes in vitro induces expression of arterial markers such as Notch1 and its ligand Delta-like 4 (Dll4), and Foxc1 and Foxc2 directly activate the Dll4 promoter via a Foxc-binding site...
  22. ncbi Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    Irene Noguera-Troise
    Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA
    Nature 444:1032-7. 2006
    ..We report that VEGF dynamically regulates tumour endothelial expression of Delta-like ligand 4 (Dll4), which was previously shown to be absolutely required for normal embryonic vascular development...
  23. ncbi Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    John Ridgway
    Tumor Biology and Angiogenesis, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 444:1083-7. 2006
    Haploinsufficiency of Dll4, a vascular-specific Notch ligand, has shown that it is essential for embryonic vascular development and arteriogenesis...
  24. ncbi Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    Mats Hellstrom
    AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 445:776-80. 2007
    ..Here we present evidence that delta-like 4 (Dll4)-Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and ..
  25. pmc Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
    I B Lobov
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 104:3219-24. 2007
    ..To better define the role of Dll4 during vascular growth and differentiation, we selected the postnatal retina as a model because its vasculature ..
  26. pmc The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
    Steven Suchting
    Institut National de la Sante et de la Recherche Medicale, U833, 75005 Paris, France
    Proc Natl Acad Sci U S A 104:3225-30. 2007
    Delta-like 4 (Dll4) is a transmembrane ligand for Notch receptors that is expressed in arterial blood vessels and sprouting endothelial cells...
  27. pmc Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
    Jeffrey S Scehnet
    Department of Pathology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, USA
    Blood 109:4753-60. 2007
    ..Notch receptors and ligands (Jagged and Delta-like) play a critical role in this process in addition to VEGF. Dll4 is one of the Notch ligands that regulates arterial specification and maturation events...
  28. pmc CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS
    Dimitris Skokos
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 204:1525-31. 2007
    ..Thus, activation of the two DC subsets by TLR4 leads to Th1 responses by two distinct MyD88-dependent pathways...
  29. pmc Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
    Matthew A Schaller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 204:2925-34. 2007
    ..Using quantitative polymerase chain reaction, we observed that only Delta-like 4 (dll4) was up-regulated on bone marrow-derived dendritic cells after respiratory syncytial virus (RSV) infection, and ..
  30. pmc Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos
    Alexandre Trindade
    Centro de Informatica do Instituto Superior de Agronomia CIISA, Lisbon Technical University, Lisbon, Portugal
    Blood 112:1720-9. 2008
    ..endothelial cells (ECs) and the observed vascular phenotypes in mutants of Notch receptors or ligands, especially Dll4. DLL4 is specifically expressed in arterial ECs during development, and haplo-insufficiency is embryonically lethal ..
  31. doi Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
    ..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors...
  32. pmc Delta-like 4 is indispensable in thymic environment specific for T cell development
    Katsuto Hozumi
    Department of Immunology and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara 259 1193, Japan
    J Exp Med 205:2507-13. 2008
    ..in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the absence of a thymic microenvironment...
  33. pmc Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland
    J Exp Med 205:2515-23. 2008
    ..Moreover, they strongly suggest that N1-expressing thymic progenitors interact with DL4-expressing TECs to suppress B lineage potential and to induce the first steps of intrathymic T cell development...
  34. pmc TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4
    Toshihiro Ito
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    J Clin Invest 119:33-46. 2009
    ..cytokine profile, decreased accumulation of granuloma-associated myeloid DCs, and profoundly impaired delta-like 4 (dll4) Notch ligand expression...
  35. doi Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms
    Thorsten B Feyerabend
    Institute for Immunology, University of Ulm, D 89081 Ulm, Germany
    Immunity 30:67-79. 2009
    ..Chimeric mice lacking the Notch ligand delta-like 4 (Dll4) in thymus epithelium revealed an essential role for Dll4 in T cell development...
  36. doi Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade
    Shinsuke Yamanda
    Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Aoba ku, Sendai, Japan
    Blood 113:3631-9. 2009
    Delta-like 4 (DLL4) is one of the Notch ligands and plays an important role in vascular development...
  37. doi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
    ..is inhibited by Notch signaling, which is activated by binding of the Notch receptor to its ligand Delta-like 4 (Dll4)...
  38. pmc Notch exhibits ligand bias and maneuvers stage-specific steering of neural differentiation in embryonic stem cells
    Saravana Kumar Ramasamy
    National Centre for Cell Science, Ganeshkhind, Pune 411007, Maharashtra, India
    Mol Cell Biol 30:1946-57. 2010
    ..Thus, our investigation underscores a multifaceted role of Notch, demonstrating the interdependency of ligand usage and lineage specification and Notch acting as a master switch, displaying stage-specific influence on neurogenesis...
  39. pmc Coronary arteries form by developmental reprogramming of venous cells
    Kristy Red-Horse
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford, California 94305 5307, USA
    Nature 464:549-53. 2010
    ..Understanding this new reprogramming process and identifying the endogenous signals should suggest more natural ways of engineering coronary bypass grafts and revascularizing the heart...
  40. doi Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes
    Mahmood Mohtashami
    Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
    J Immunol 185:867-76. 2010
    ..However, using cocultures, either Dll4 or Dll1 were shown to support T lymphopoiesis...
  41. doi The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling
    Monica Corada
    IFOM, The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Dev Cell 18:938-49. 2010
    ..Both in vivo and in vitro data show that beta-catenin upregulates Dll4 transcription and strongly increases Notch signaling in the endothelium, leading to functional and morphological ..
  42. pmc Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis
    Dusan Djokovic
    Department of Pathology, University of Southern California, Los Angeles, USA
    BMC Cancer 10:641. 2010
    b>Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel development and maturation...
  43. pmc Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
    Luca Pellegrinet
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
    Gastroenterology 140:1230-1240.e1-7. 2011
    ..Furthermore, we investigated whether the induction of goblet cell differentiation that results from loss of Notch requires the transcription factor Krüppel-like factor 4 (Klf4)...
  44. pmc Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac
    Jessica N Copeland
    Department of Pathology and Laboratory Medicine and Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    BMC Dev Biol 11:12. 2011
    ..To further understand the role of Notch signaling during endothelial differentiation and the genes regulated by this pathway, both loss-of-function and gain-of-function approaches were analyzed in vivo...
  45. pmc Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis
    Carla Real
    Angiogenesis Laboratory, CIPM Portuguese Institute of Oncology, Lisbon, Portugal
    PLoS ONE 6:e18323. 2011
    ..growth factor (VEGF), recent findings show the Notch signalling pathway, in particular the ligand Delta-like 4 (Dll4), is also essential for adequate tumor angiogenesis; Dll4 inhibition results in impaired, non-functional, ..
  46. doi Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus
    Fabienne Billiard
    Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA
    Eur J Immunol 41:2207-16. 2011
    The essential role of the Delta-like ligand 4 (Dll4)-Notch signaling pathway in T-lymphocyte development is well established...
  47. doi The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development
    Kyle Niessen
    Department of Molecular Biology, Division of Research, Genentech Inc, South San Francisco, CA 94080, USA
    Blood 118:1989-97. 2011
    ..In this report, we show that blockade of Notch1 and Dll4, with specific function-blocking antibodies, results in defective postnatal lymphatic development in mice...
  48. pmc Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development
    Ribal Bassil
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 187:2322-8. 2011
    ..However, the role of Dll4 in Th1/Th17-mediated autoimmune diseases remains largely unknown...
  49. doi Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling
    Rui Benedito
    Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, D 48149 Munster, Germany
    Nature 484:110-4. 2012
    ..Signalling triggered by VEGF-A (also known as VEGF) has been shown to induce expression of the Notch ligand DLL4 in angiogenic vessels and, most prominently, in the tip of endothelial sprouts...
  50. pmc Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling
    Bingruo Wu
    Departments of Genetics, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 151:1083-96. 2012
    ..This information may help develop better cell therapies for coronary artery disease...
  51. pmc Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
    Brunella Cristofaro
    CIRB College de France, Inserm U1050 CNRS UMR 7241, Paris, France
    Development 140:1720-9. 2013
    ..The Notch ligand Delta-like 4 (Dll4) promotes arterial differentiation and restricts vessel branching...
  52. pmc Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development
    Natalia Sacilotto
    Ludwig Institute for Cancer Research Ltd, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Proc Natl Acad Sci U S A 110:11893-8. 2013
    ..characterization of two arterial endothelial cell-specific gene enhancers for the Notch ligand Delta-like ligand 4 (Dll4), we show that arterial Dll4 expression requires the direct binding of both the RBPJ/Notch intracellular domain and ..
  53. pmc ETS factors regulate Vegf-dependent arterial specification
    Joshua D Wythe
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 26:45-58. 2013
    ..signaling specifies arterial fate during early vascular development by inducing the transcription of Delta-like 4 (Dll4), the earliest Notch ligand gene expressed in arterial precursor cells...
  54. ncbi In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects
    Alix de La Coste
    Unité de Biologie des Populations Lymphocytaires, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2582, Paris, France
    J Immunol 174:2730-7. 2005
    ....
  55. ncbi The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions
    Patricia Hainaud
    Institut des Vaisseaux et du Sang, INSERM U689, IFR139, Paris VII Denis Diderot, Hopital Lariboisiere, Paris, France
    Cancer Res 66:8501-10. 2006
    Vascular endothelial growth factor (VEGF) and Delta-like 4 ligand (DLL4) are the only genes whose haploinsufficiency results in vascular abnormalities...
  56. pmc Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation
    Sumanta Mukherjee
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 182:7381-8. 2009
    ..In the present studies we have investigated the role of a specific notch ligand, delta-like 4 (Dll4)...
  57. ncbi Lack of Delta like 1 and 4 expressions in nude thymus anlages
    Noriyuki Tsukamoto
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Funai gun, Kyoto 629 0392, Japan
    Cell Immunol 234:77-80. 2005
    ..We investigated the expressions of Delta like (Dll) 1 and Dll4 in the mouse thymus anlages...
  58. pmc Vascular endothelial growth factor-A inhibits EphB4 and stimulates delta-like ligand 4 expression in adult endothelial cells
    Chenzi Yang
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, Connecticut 06520 8089, USA
    J Surg Res 183:478-86. 2013
    ..In addition, although VEGF-A stimulates angiogenesis and determines arterial identity in nascent arterial endothelial cells (EC), the role of VEGF-A in regulating identity in adult venous EC is also not clear...
  59. pmc Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
    Amir Rattner
    Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 110:E3830-9. 2013
    ..The response to Edn2 is sufficiently potent that it overrides the activities of other homeostatic regulators of angiogenesis, such as Vegf. ..
  60. doi Inhibition of Delta-like 4 mediated signaling induces abortion in mice due to deregulation of decidual angiogenesis
    C M García-Pascual
    Fundacion IVI, Instituto Universitario IVI INCLIVA, 46015, C Catedrático Agustín Escardino n 9, PARC CIENTIFIC UNIVERSITAT DE VALENCIA Edificio 3, CUE 2ª Planta Despacho 2 02, 46980 Paterna Valencia, Spain
    Placenta 35:501-8. 2014
    To explore whether the Dll4/Notch1 pathway plays a key role in regulating the vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) driven decidual angiogenesis and related pregnancy through induction of a tip/stalk phenotype.
  61. pmc Sex steroid blockade enhances thymopoiesis by modulating Notch signaling
    Enrico Velardi
    Immunology Program, Department of Medicine, and Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Department of Clinical and Experimental Medicine, University of Perugia, 06122 Perugia, Italy
    J Exp Med 211:2341-9. 2014
    ..influence thymopoiesis is through direct inhibition in cortical thymic epithelial cells (cTECs) of Delta-like 4 (Dll4), a Notch ligand crucial for the commitment and differentiation of T cell progenitors in a dose-dependent manner...
  62. pmc VEGFR3 does not sustain retinal angiogenesis without VEGFR2
    Georgia Zarkada
    Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 112:761-6. 2015
    ..abundant in the tip cells of angiogenic sprouts, where VEGF/VEGFR2 functions upstream of the delta-like ligand 4 (DLL4)/Notch signal transduction pathway...
  63. pmc Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure
    Jun ichiro Koga
    From The Center for Excellence in Vascular Biology J K, T N, J L F, T N, M A, The Center for Interdisciplinary Cardiovascular Sciences J L F, H Z, J D, H I, M A, and Channing Division of Network Medicine M A, Department of Medicine, Brigham and Women s Hospital, Boston, MA Department of Pathology J C A, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Division of Vascular and Endovascular Surgery, Department of Surgery C K O, Brigham and Women s Hospital, Harvard Medical School, Boston, MA David H Koch Institute for Integrative Cancer Research J E D, O F K, D G A, Harvard MIT Division of Health Sciences and Technology J E D, O F K, D G A, Institutes for Medical Engineering and Science J E D, O F K, D G A, and Department of Chemical Engineering D G A, Massachusetts Institute of Technology, Cambridge, MA and Department of Immunology, Juntendo University School of Medicine, Tokyo
    Arterioscler Thromb Vasc Biol 35:2343-53. 2015
    ..Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested the hypothesis that Notch signaling promotes vein graft disease...
  64. doi Neuralized-2: expression in human and rodents and interaction with Delta-like ligands
    Grete Rullinkov
    Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia
    Biochem Biophys Res Commun 389:420-5. 2009
    ..Neur2 protein has a predominantly cytoplasmic localization. We also show that in addition to Delta-like1, Neur1 and Neur2 interact with another Notch ligand, Delta-like4...
  65. doi Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors
    Julie S Yuan
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 101 College Street, Toronto, Ontario, Canada
    Blood 117:1184-95. 2011
    ..Our data provide novel insights into the Notch-pre-TCR collaboration, and suggest that decreasing Lfng expression during the DN3-DP transition minimizes the potent leukemogenic potential of Notch1 signaling...
  66. pmc Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors
    Julia Heisig
    Developmental Biochemistry, Theodor Boveri Institute, Biocenter, University of Wuerzburg, Wuerzburg, Germany
    PLoS Genet 8:e1002728. 2012
    ..These data clearly establish the three HEY bHLH factors as highly redundant transcriptional repressors in vitro and in vivo, which explains the combinatorial action observed in different tissues with overlapping expression...
  67. ncbi Molecular cloning of delta-4, a new mouse and human Notch ligand
    T Yoneya
    Pharmaceutical Research Laboratory, Kirin Brewery Co Ltd, Miyahara, Takasaki, Gunma 370 1295, Japan
    J Biochem 129:27-34. 2001
    ..Soluble forms of the extracellular portion of Delta-4 inhibit the apparent proliferation of human aortic endothelial cells, but not human pulmonary arterial endothelial cells...
  68. ncbi Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad
    Jennifer Brennan
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 244:418-28. 2002
    ..This newly formed arterial system establishes a new pattern of blood flow in the XY gonad, which we speculate may have an important role in export of testosterone to masculinize the XY embryo...
  69. pmc A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development
    Takamune Takahashi
    Nephrology Division and Center for Vascular Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:1817-31. 2003
    ..These findings implicate a member of the receptor tyrosine phosphatase family, CD148, in developmental vascular organization and provide evidence that it regulates endothelial proliferation and endothelium-pericyte interactions...
  70. ncbi Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development
    Cornelia Leimeister
    Theodor Boveri Institute, Biozentrum, Physiological Chemistry I, University of Wuerzburg, Am Hubland, 97074, Wuerzburg, Germany
    Gene Expr Patterns 3:595-8. 2003
    ..Our results point to a Lfng-dependent role for Notch signalling in the development of nephron segments, especially the proximal tubules...
  71. ncbi Developmental expression of the Notch signaling pathway genes during mouse preimplantation development
    Sarah Cormier
    Unite de Biologie du Developpement, Institut Pasteur, CNRS URA 2578, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Gene Expr Patterns 4:713-7. 2004
    ..Finally, we show that all the above genes are expressed both in Embryonic and Trophoblast Stem cells (ES and TS cells, respectively). Our results suggest that the Notch pathway may be active during mouse preimplantation development...
  72. ncbi Function of Delta4 gene and its effects on 32D cell differentiation
    Chun Yan Ji
    Institute of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China
    Chin Med J (Engl) 117:1687-92. 2004
    ..The Notch signal system contains three parts: Notch molecules, Notch ligands and effectors. Delta4 is a newly-discovered Notch ligand which has received the attention of few detailed studies...
  73. ncbi Delta-4 expression on a stromal cell line is augmented by interleukin-6 via STAT3 activation
    Motoyuki Suzuki
    Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Exp Hematol 34:1143-50. 2006
    ..In this study, we focused on a new member of Notch ligand family, Delta-4, and analyzed regulatory mechanisms of Delta-4 expression by cytokines using stromal cell lines...
  74. ncbi Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium
    Gerald A Schwarting
    Shriver Center UMMS, 200 Trapelo Road, Waltham, MA 02452, USA
    J Mol Histol 38:543-53. 2007
    ..The Notch ligand Dll4 is expressed by basal OE cells that are interspersed with Notch1(+) progenitors during later OE neurogenesis...
  75. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
  76. ncbi Negative regulators of vessel patterning
    Steven Suchting
    Inserm U833, Collge de France, 11 place Marcelin Berthelot, 75005 Paris, France
    Novartis Found Symp 283:77-80; discussion 80-6, 238-41. 2007
    ..that endothelial tip cell formation and vessel branching are negatively regulated by the Notch ligand Delta-like 4 (Dll4)...
  77. doi Notch signaling is required for the maintenance of enteric neural crest progenitors
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3555-65. 2008
    ....
  78. pmc Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis
    Yung Hae Kim
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Development 135:3755-64. 2008
    ..Our findings provide mechanistic insight into the processes underlying artery and vein size equilibration during angiogenesis...
  79. pmc Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli
    Rui Benedito
    Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisboa, Portugal
    BMC Dev Biol 8:117. 2008
    In the vascular system, Notch receptors and ligands are expressed mainly on arteries, with Delta-like 4 (Dll4) being the only ligand known to be expressed early during the development of arterial endothelial cells and capillaries...
  80. doi Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis
    Nadine Kassner
    Deutsches Rheuma ForschungsZentrum Berlin, Berlin, Germany
    J Immunol 184:550-4. 2010
    ..We provide a new mechanism for IL-10 induction by pDCs underlining the importance of the Dll-4/Notch axis in the regulation of inflammatory T cell responses...
  81. pmc RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
    Yufeng Dong
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 137:1461-71. 2010
    ..Finally, Hes1 was identified as an RBPjkappa-dependent Notch target gene important for MPC maintenance and the suppression of in vitro chondrogenesis...
  82. pmc Increased expression of angiogenic genes in the brains of mouse meg3-null embryos
    Francesca E Gordon
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Endocrinology 151:2443-52. 2010
    ..In conclusion, Meg3 may play an important role in control of vascularization in the brain and may function as a tumor suppressor in part by inhibiting angiogenesis...
  83. doi Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis
    Catarina Catela
    EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo RM, Italy
    Dev Dyn 239:2149-60. 2010
    ..These findings uncover a novel and essential function for SGK1 in cardiovascular development contributing to a better understanding of mammalian angiogenesis...
  84. doi Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate
    Natsumi Abe
    Department of Immunology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Eur J Immunol 40:2608-17. 2010
    ..Stromal cells expressing Dll4 or Dll1, but not Jagged1, support T lymphopoiesis in vitro, but the molecular basis of this functional divergence ..
  85. pmc Identification and functional analysis of endothelial tip cell-enriched genes
    Raquel del Toro
    Inserm U833, Paris, France
    Blood 116:4025-33. 2010
    ..Expression of the Notch ligand Delta-like-4 (Dll4) in tip cells suppresses tip cell fate in neighboring stalk cells via Notch signaling...
  86. pmc Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1
    Matthew A Schaller
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e12172. 2010
    ..It has also been shown that Notch ligands have diverse functions during T cell activation. We chose to investigate the role of Notch ligands during the Th2 response...
  87. pmc Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity
    Sihyug Jang
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 185:5835-44. 2010
    ..In this study, we show that delta-like ligand 4 (Dll4) was upregulated on dendritic cells in response to cockroach allergen...
  88. pmc Delta-like ligand 4-Notch signaling regulates bone marrow-derived pericyte/vascular smooth muscle cell formation
    Keri Schadler Stewart
    The Children s Cancer Hospital, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 117:719-26. 2011
    Delta-like ligand 4 (DLL4) is essential for the formation of mature vasculature. However, the role of DLL4-Notch signaling in pericyte/vascular smooth muscle cell (vSMC) development is poorly understood...
  89. doi Differential regulation of Notch ligands in dendritic cells upon interaction with T helper cells
    D Sauma
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    Scand J Immunol 74:62-70. 2011
    ..Based on our results, we propose that the positive feedback loop that Th2 cells exert on T cell polarization may involve the induction of Jagged 2 expression in DCs...
  90. pmc Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression
    Matthew R Mysliwiec
    Department of Anatomy, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 286:17193-204. 2011
    ..The identification of Jarid2 as a potential regulator of Notch1 signaling has broad implications for many cellular processes including development, stem cell maintenance, and tumor formation...
  91. doi Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon
    Shengxi Wu
    Department of Morphological Neural Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556 Japan
    Development 138:2499-509. 2011
    ..IPGNs are maintained in the neocortex and may act as progenitors for adult neurogenesis...
  92. pmc Delta-like ligand 4 regulates central nervous system T cell accumulation during experimental autoimmune encephalomyelitis
    Nathanael D Reynolds
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 187:2803-13. 2011
    ..that CNS-infiltrating myeloid dendritic cells, macrophages, and resident microglia expressed Delta-like ligand 4 (DLL4) after EAE induction...
  93. pmc Stepwise arteriovenous fate acquisition during mammalian vasculogenesis
    Diana C Chong
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Dev Dyn 240:2153-65. 2011
    ..Together, our results provide a first spatiotemporal analysis of mammalian AV cell fate establishment and anatomy, as well as a delineation of a molecular toolkit for analysis of arteries and veins during early vessel development...
  94. ncbi Isolation and characterization of the notch ligand delta4
    P K Rao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA
    Exp Cell Res 260:379-86. 2000
    ..Here we present the isolation of a novel Notch ligand, Delta4. Expression analyses indicate that mouse Delta4 is highly expressed in the eye and lung during embryogenesis and ..
  95. ncbi Expression of Notch pathway components in fetal and adult mouse small intestine
    Natalia Schröder
    Institut für Molekularbiologie OE5250, Medizinische Hochschule Hannover, Carl Neubergstrasse 1, D 30625 Hannover, Germany
    Gene Expr Patterns 2:247-50. 2002
    ....
  96. ncbi Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
    Roi Gazit
    Cell and Animal Biology, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Development 131:903-13. 2004
    ..Taken together, our data demonstrate that CGC differentiation, but not specification, depends on Math1, which acts by regulating the level of multiple components of the Notch signaling pathway...
  97. ncbi Segmental expression of Notch and Hairy genes in nephrogenesis
    Linghong Chen
    Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 W 168th St, New York, NY 10032, USA
    Am J Physiol Renal Physiol 288:F939-52. 2005
    ..These studies provide the basis for the future development of strategies to examine the role of individual effector molecules in the determination of the differentiation pattern of the nephron...
  98. ncbi Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud
    Jeffrey C Francis
    Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London, UK
    Dev Dyn 234:1006-15. 2005
    ..Regulation of the extent of the AER is achieved by Notch signalling positively regulating apoptosis in the AER. We also demonstrate that Notch1 is not required for proper formation of all the derivatives of the limb mesenchyme...
  99. ncbi A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool
    Marta G del Barrio
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 134:3427-36. 2007
    ..We show here in experiments conducted using mouse and chick that Foxn4 induces expression of delta-like 4 (Dll4) and Mash1 (Ascl1). Dll4 then signals through Notch1 to subdivide the p2 progenitor pool...
  100. pmc Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1
    Alex Robert-Moreno
    Centre Oncologia Molecular, IDIBELL, Gran Via km 2 7 Hospitalet, Barcelona, Spain
    EMBO J 27:1886-95. 2008
    ..Taken together, our results indicate that Jagged1-mediated activation of Notch1 is responsible for regulating GATA2 expression in the AGM, which in turn is essential for definitive haematopoiesis in the mouse...
  101. pmc Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells
    Hisaki Hayashi
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 3:e2401. 2008
    ..for arterial cell specification during development by directly inducing the transcription of Delta-like 4 (Dll4), a ligand for Notch receptors...

Research Grants5

  1. NOTCH SIGNALING IN HEMATOPOIETIC CELLS
    THOMAS KADESCH; Fiscal Year: 2002
    ..Experiments are proposed to characterize signaling through Deltex. ..
  2. TRANSCRIPTIONAL DETERMINANTS OF B LYMPHOCYTES
    THOMAS KADESCH; Fiscal Year: 2002
    ....
  3. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
    ..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..
  4. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
    ..These studies will lead to an understanding of the complex factors that guide GnRH neurons to their proper destinations in the hypothalamus to control the hypothalamic-pituitary-gonadal axis. ..