Dio3

Summary

Gene Symbol: Dio3
Description: deiodinase, iodothyronine type III
Alias: thyroxine 5-deiodinase, 5DIII, DIOIII, type 3 DI, type III iodothyronine deiodinase, type-III 5'-deiodinase
Species: mouse

Top Publications

  1. pmc A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints
    Xiajun Li
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:547-57. 2008
  2. ncbi Genomic imprinting contributes to thyroid hormone metabolism in the mouse embryo
    Chen En Tsai
    Department of Anatomy, University of Cambridge, Downing Street, United Kingdom
    Curr Biol 12:1221-6. 2002
  3. ncbi The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts
    Arturo Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Endocrinology 143:4483-6. 2002
  4. doi Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice
    Nozomi Takahashi
    Department of Bioscience, Tokyo University of Agriculture, Setagaya Ku, Tokyo, Japan
    Hum Mol Genet 18:1879-88. 2009
  5. ncbi Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12
    Shau Ping Lin
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Nat Genet 35:97-102. 2003
  6. pmc Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells
    Lei Liu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China
    J Biol Chem 285:19483-90. 2010
  7. pmc Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene
    Yunli Zhou
    Massachusetts General Hospital, Boston, MA 02114, USA
    Development 137:2643-52. 2010
  8. ncbi Aberrant regulation of imprinted gene expression in Gtl2lacZ mice
    Y Sekita
    Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cytogenet Genome Res 113:223-9. 2006
  9. pmc Type 3 deiodinase is critical for the maturation and function of the thyroid axis
    Arturo Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Clin Invest 116:476-84. 2006
  10. ncbi High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12
    Sascha Tierling
    Genetik Epigenetik, FR 8 3 Biowissenschaften, Universitat des Saarlandes, Postfach 151150, D 66041 Saarbrucken, Germany
    Genomics 87:225-35. 2006

Research Grants

Scientific Experts

  • A Boelen
  • Ulrich Schweizer
  • R P Peeters
  • Yunli Zhou
  • Xiajun Li
  • Arturo Hernandez
  • Marika Charalambous
  • Antonio C Bianco
  • Zhengbin Han
  • Valerie Anne Galton
  • Mayrin C Medina
  • Qiong Wu
  • Nozomi Takahashi
  • Donald L St Germain
  • Anne C Ferguson-Smith
  • Lily Ng
  • Virginie Marty
  • Wei Cui
  • Warner S Simonides
  • Cristina Luongo
  • Gordana Simovic
  • Stephane Labialle
  • Tomohiro Kono
  • Jerome Cavaille
  • Monica Dentice
  • Theo J Visser
  • Rujuan Dai
  • Yonatan Stelzer
  • Tatiana L Fonseca
  • Osamu Araki
  • Xingbo Xu
  • Omer Habib
  • Shigeo Akiyama
  • M Elena Martinez
  • Wen Bo Deng
  • Yijun Tian
  • Tie Bo Zeng
  • Qi Liu
  • Alfonso Massimiliano Ferrara
  • Harri Lempiäinen
  • Shinpei Yamaguchi
  • Marie Line Bortolin-Cavaillé
  • Rob Janssen
  • Natalyia Markova
  • Christine M Snyder
  • Alberto Fachado
  • Judith Molina
  • Xiao Hui Liao
  • Cintia B Ueta
  • Samuel Refetoff
  • Julie Seibt
  • Alice Muller
  • Roy E Weiss
  • Yi Lin
  • Christine J Pol
  • Anna K Naumova
  • Max P Huang
  • Olga Barca-Mayo
  • Caterina Missero
  • Raffaele Ambrosio
  • Andrzej A Dlugosz
  • Patrice Vitali
  • Jessica A Hall
  • Lei Liu
  • Chen En Tsai
  • Maya Srinivas
  • Douglas Forrest
  • Michelle Ma
  • Shau Ping Lin
  • Monique H A Kester
  • John P Hagan
  • Takayuki Ogiwara
  • Masami Murakami
  • Luciane P Capelo
  • Manabu Kawahara
  • Sascha Tierling
  • Y Sekita
  • Martina Paulsen
  • Yuelin Song
  • Hao Wu
  • Ran Lu
  • S Ansar Ahmed
  • Chikdu S Shivalila
  • Gabriela Ferreira De Medeiros
  • Rudolf Jaenisch
  • Marie Pierre Moisan
  • Styliani Markoulaki
  • Sonke Friedrichsen
  • Cedrick Florian
  • Tiebo Zeng

Detail Information

Publications63

  1. pmc A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints
    Xiajun Li
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:547-57. 2008
    ..The effects on genomic imprinting are consistent with the maternal-zygotic lethality of Zfp57 mutants...
  2. ncbi Genomic imprinting contributes to thyroid hormone metabolism in the mouse embryo
    Chen En Tsai
    Department of Anatomy, University of Cambridge, Downing Street, United Kingdom
    Curr Biol 12:1221-6. 2002
    ..D3 inactivates thyroxine (T4) and T3 by 5-deiodination, and the gene for this enzyme, Dio3, lies in the imprinted domain on human chromosome 14q32/distal mouse chromosome 12...
  3. ncbi The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts
    Arturo Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Endocrinology 143:4483-6. 2002
    The mouse Dio3 gene codes for the type 3 iodothyronine deiodinase (D3), a conserved selenocysteine-containing enzyme that inactivates thyroid hormones and is highly expressed during early development...
  4. doi Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice
    Nozomi Takahashi
    Department of Bioscience, Tokyo University of Agriculture, Setagaya Ku, Tokyo, Japan
    Hum Mol Genet 18:1879-88. 2009
    The cluster of imprinted genes located in the Dlk1-Dio3 domain spanning 1 Mb plays an essential role in controlling pre- and postnatal growth and differentiation in mice and humans...
  5. ncbi Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12
    Shau Ping Lin
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Nat Genet 35:97-102. 2003
    ..5). The 1-Mb cluster contains the paternally expressed protein-coding genes Dlk1 (refs. 6,7) and Dio3 (ref. 8,9) and several maternally expressed non-coding RNAs, including Gtl2 (refs. 6,7,10) and C/D snoRNAs...
  6. pmc Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells
    Lei Liu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China
    J Biol Chem 285:19483-90. 2010
    ..We have identified a conserved imprinted region of the mouse genome, the Dlk1-Dio3 region, which was activated in fully pluripotent mouse stem cells but repressed in partially pluripotent cells...
  7. pmc Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene
    Yunli Zhou
    Massachusetts General Hospital, Boston, MA 02114, USA
    Development 137:2643-52. 2010
    ..These data strongly indicate that activation of Gtl2 and its downstream maternal genes play an essential role in regulating Dlk1-Gtl2 imprinting, possibly by maintaining active status of the IG-DMR...
  8. ncbi Aberrant regulation of imprinted gene expression in Gtl2lacZ mice
    Y Sekita
    Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cytogenet Genome Res 113:223-9. 2006
    ..12 covers about 1 Mb and contains at least three paternally expressed genes (Pegs: Peg9/Dlk1, Peg11/Rtl1, and Dio3) and four maternally expressed genes (Megs: Meg3/Gtl2, antiPeg11/antiRlt1, Meg8/Rian, and Meg9/Mirg)...
  9. pmc Type 3 deiodinase is critical for the maturation and function of the thyroid axis
    Arturo Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Clin Invest 116:476-84. 2006
    ..role of D3, we have generated a mouse D3 knockout model (D3KO) by a targeted inactivating mutation of the Dio3 gene in mouse ES cells...
  10. ncbi High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12
    Sascha Tierling
    Genetik Epigenetik, FR 8 3 Biowissenschaften, Universitat des Saarlandes, Postfach 151150, D 66041 Saarbrucken, Germany
    Genomics 87:225-35. 2006
    The imprinted Dlk1-Dio3 region on mouse chromosome 12 contains six imprinted genes and a number of maternally expressed snoRNAs and miRNAs. Here we present a high-resolution sequence analysis of the 1...
  11. pmc Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions
    M Elena Martinez
    Department of Molecular Medicine M E M, D S G, A H, Maine Medical Center Research Institute, Scarborough, Maine 04074 Centre for Endocrinology M C, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 1BB, United Kingdom Department of Obstetrics and Gynecology and Human Genetics A S, A K N, McGill University, Montreal, Quebec, Canada H9X 3V9 Department of Microbiology and Immunology S F, Dartmouth Medical School, Lebanon, New Hampshire 03756 and Department of Genetics A C F S, University of Cambridge, Cambridge CB2 1TN, United Kingdom
    Mol Endocrinol 28:1875-86. 2014
    The Dio3 gene, which encodes for the type 3 deiodinase (D3), controls thyroid hormone (TH) availability. The lack of D3 in mice results in tissue overexposure to TH and a broad neuroendocrine phenotype...
  12. pmc Hippocampal gene expression of deiodinases 2 and 3 and effects of 3,5-diiodo-L-thyronine T2 in mouse depression paradigms
    Natalyia Markova
    Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnii proesd 1, Chernogolovka, Moscow Region 142432, Russia
    Biomed Res Int 2013:565218. 2013
    ..This demonstrates an antidepressant-like effect of T2 that could be exploited clinically. In a wider context, the current study suggests important central functions of T2, whose biological role only lately is becoming to be elucidated...
  13. pmc Role of Tet1 in erasure of genomic imprinting
    Shinpei Yamaguchi
    1 Howard Hughes Medical Institute, Boston Children s Hospital, Boston, Massachusetts 02115, USA 2 Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, Massachusetts 02115, USA 3 Division of Hematology Oncology, Department of Pediatrics, Boston Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 504:460-4. 2013
    ..Furthermore, we provide evidence supporting the role of Tet1 in the erasure of paternal imprints in the female germ line. Thus, our study establishes a critical function of Tet1 in the erasure of genomic imprinting. ..
  14. pmc Changes in thyroid status during perinatal development of MCT8-deficient male mice
    Alfonso Massimiliano Ferrara
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Endocrinology 154:2533-41. 2013
    ..This report is the first to identify that the ontogenesis of TH abnormalities in Mct8-deficient mice manifests with TH excess in the perinatal period...
  15. pmc Ground-state conditions promote robust Prdm14 reactivation and maintain an active Dlk1-Dio3 region during reprogramming
    Omer Habib
    Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 143 701, Korea Stem Cell Research Laboratory, CHA Stem Cell Institute, CHA University, Seoul 135 907, Korea
    Mol Cells 37:31-5. 2014
    ..However, iPSC generation may result in subtle epigenetic variations, such as the aberrant methylation of the Dlk1-Dio3 locus, among the clones, and this heterogeneity constitutes a major drawback to harnessing the full potential of ..
  16. pmc The 5'-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone
    Valerie Anne Galton
    Departments of Physiology and Neurobiology V A G, D L St G and Medicine D L St G, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756 and Maine Medical Center Research Institute A H, D L St G, Scarborough, Maine 04074
    Endocrinology 155:3172-81. 2014
    ..Thus, the systemic changes in thyroid hormone economy as a result of acute food deprivation are not dependent on the D1 or D2 but are mediated in part by sequestration of T4 and T3 in tissues and their enhanced metabolism by the D3. ..
  17. pmc Expression and imprinting analysis of AK044800, a transcript from the Dlk1-Dio3 imprinted gene cluster during mouse embryogenesis
    Zhengbin Han
    School of Life Science and Technology, Harbin Institute of Technology, Science Park of Harbin Institute of Technology, Harbin, China
    Mol Cells 35:285-90. 2013
    ..that full development potential is closely related with the expression state of noncoding RNAs (ncRNAs) of the Dlk1-Dio3 imprinted gene cluster...
  18. doi The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation
    Cristina Luongo
    Department of Clinical Medicine Surgery C L, M D, University of Naples Federico II, 80131 Naples, Italy Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Studio di Diagnostica Nucleare R A, 80142 Naples, Italy Institute of Experimental Endocrinology and Oncology G Salvatore Consiglio Nazionale delle Ricerche S S, 80131 Naples, Italy Department of Dermatology and Comprehensive Cancer Center A A D, University of Michigan, Ann Arbor, Michigan 48109 and Centro di Ingegneria Genetica Biotecnologie Avanzate Scarl C M, 80131 Naples, Italy
    Endocrinology 155:2077-88. 2014
    ..TH-mediated Gli2 inactivation would be beneficial for therapeutically purposes, because the inhibition of Shh-Gli2 signaling is an attractive target for several anticancer drugs, currently in clinical trials. ..
  19. doi Regulation and function of deiodinases during decidualization in female mice
    Wen Bo Deng
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
    Endocrinology 155:2704-17. 2014
    ..Once the embryo implants into the receptive uterus, type III deiodinase (Dio3), a mainly paternally imprinted gene for inactivating T3, is significantly induced in the stromal cells and ..
  20. doi The thyroid hormone degrading type 3 deiodinase is the primary deiodinase active in murine epidermis
    Max P Huang
    Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Thyroid 21:1263-8. 2011
    ..In our hands a nonspecific deiodinase inhibitor (iopanoic acid [IOP]) decreased cutaneous cell proliferation in vitro, so we hypothesized that topical IOP would inhibit epidermal proliferation in vivo...
  21. pmc Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis
    Mayrin C Medina
    University of Miami Miller School of Medicine, Division of Endocrinology and Metabolism M C M, J M, M C, L D, R S, A C, Miami, Florida 33136 Rush University Medical Center T L F, A C B, Chicago, Illinois 60612 and Diabetes Research Institute A F, Maine Medical Center Research Institute A H, Scarborough, Maine 04074
    Endocrinology 155:3160-71. 2014
    b>Dio3 is the most distal gene of the imprinted Dlk1-Dio3 gene locus and is expressed according to parental origin...
  22. pmc Life without the iodothyronine deiodinases
    Valerie Anne Galton
    The Departments of Physiology and Neurobiology V A G, D L S and Medicine D L S, Geisel School of Medicine, Dartmouth University, Lebanon, New Hampshire 03756 Maine Medical Center Research Institute A H, D L S, Scarborough, Maine 04074 and Department of Veterans Affairs Medical Center A H, Long Beach, California 90822 Harbor UCLA Medical Center A F P, Torrance, California 90509 and Department of Endocrinology E d W, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    Endocrinology 155:4081-7. 2014
    ....
  23. pmc Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
    Ulrich Schweizer
    Institut fur Biochemie und Molekularbiologie, Rheinische Friedrich Wilhelms Universitat Bonn, 53115 Bonn, Germany
    Proc Natl Acad Sci U S A 111:10526-31. 2014
    ..We solved the crystal structure of the catalytic domain of mouse deiodinase 3 (Dio3), which reveals a close structural similarity to atypical 2-Cys peroxiredoxin(s) (Prx)...
  24. ncbi Isolation and characterization of the mouse gene for the type 3 iodothyronine deiodinase
    A Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Endocrinology 140:124-30. 1999
    ..a mouse liver genomic library with a rat D3 complementary DNA probe and isolated a 12-kb clone coding for the Dio3. Restriction analysis followed by Southern blotting and nucleotide sequencing demonstrated that the Dio3 contains a ..
  25. doi Glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in a mouse insulinoma cell line
    Shigeo Akiyama
    Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Life Sci 115:22-8. 2014
    ..In the present study, we identified D3 expression in MIN6 cells derived from a mouse insulinoma cell line and examined the mechanisms regulating D3 expression in these cells...
  26. pmc Deleting maternal Gtl2 leads to growth enhancement and decreased expression of stem cell markers in teratoma
    Nozomi Takahashi
    Department of Bioscience, Tokyo University of Agriculture, Tokyo 156 0054, Japan
    J Reprod Dev 61:7-12. 2015
    The distal region of mouse chromosome 12 harbors the Dlk1-Dio3 domain, is essential for normal development and encodes maternally expressed noncoding RNAs (ncRNAs), including Gtl2 as well as paternally expressed proteins...
  27. doi DNA methylation dynamics of a maternally methylated DMR in the mouse Dlk1-Dio3 domain
    Tie Bo Zeng
    School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China
    FEBS Lett 588:4665-71. 2014
    The mouse delta-like homolog 1 and type III iodothyronine deiodinase (Dlk1-Dio3) imprinted domain contains three known paternally methylated differentially methylated regions (DMRs): intergenic DMR (IG-DMR), maternally expressed 3-DMR (..
  28. pmc Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting
    Xingbo Xu
    Institute of Human Genetics, University of Goettingen, Heinrich Dueker Weg 12, 37073 Goettingen, Germany
    Nat Commun 6:6008. 2015
    ..Lg-iPSC transcriptome analysis revealed misregulated Dlk1-Dio3 cluster gene expression and subsequently the imprinting defect at the Dlk1-Dio3 locus...
  29. doi Expression patterns of long noncoding RNAs from Dlk1-Dio3 imprinted region and the potential mechanisms of Gtl2 activation during blastocyst development
    Zhengbin Han
    Harbin Institute of Technology, School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin 150080, China University of Massachusetts, Veterinary and Animal Science Department, 661 North Pleasant Street, Amherst, MA 01003, USA
    Biochem Biophys Res Commun 463:167-73. 2015
    ..LncRNAs expressed from Dlk1-Dio3 imprinted region have been linked to pluripotency of induced pluripotent cells (iPSCs)...
  30. pmc Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity
    Tatiana L Fonseca
    Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL 60612
    Proc Natl Acad Sci U S A 112:14018-23. 2015
    ..The resulting phenotype of the adult ALB-D2KO mouse is dramatic, with greatly reduced susceptibility to diet-induced steatosis, hypertriglyceridemia, and obesity. ..
  31. doi Deletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour
    Virginie Marty
    Laboratoire de Biologie Moleculaire Eucaryote, Universite de Toulouse, UPS and CNRS, LBME, F 31000 Toulouse, France
    Hum Mol Genet 25:728-39. 2016
    The brain-specific miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 domain is implicated in several aspects of brain development and function, particularly in fine-tuning the dendritic outgrowth and spine remodelling of hippocampal ..
  32. pmc The Upregulation of Genomic Imprinted DLK1-Dio3 miRNAs in Murine Lupus Is Associated with Global DNA Hypomethylation
    Rujuan Dai
    Infectious Disease Research Facility IDRF, Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine VMCVM, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 11:e0153509. 2016
    ..Here, we report that a majority of the upregulated miRNAs in MRL-lpr mice is located at the genomic imprinted DLK1-Dio3 domain...
  33. pmc Parent-of-Origin DNA Methylation Dynamics during Mouse Development
    Yonatan Stelzer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Rep 16:3167-80. 2016
    ..To test this hypothesis, we targeted a reporter for genomic methylation to the imprinted Dlk1-Dio3 intergenic DMR (IG-DMR) to assess the methylation of both parental alleles at single-cell resolution...
  34. ncbi Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1
    A Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire, 03756, USA
    Genomics 53:119-21. 1998
  35. ncbi Activity and response to serum of the mammalian thyroid hormone deiodinase 3 gene promoter: identification of a conserved enhancer
    Arturo Hernandez
    Departments of Medicine and Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Mol Cell Endocrinol 206:23-32. 2003
    b>Dio3 is an imprinted gene that codes for the type 3 deiodinase (D3), a conserved selenocysteine-containing enzyme that degrades thyroid hormones (TH) into inactive metabolites...
  36. ncbi Induction of type 3 deiodinase activity in inflammatory cells of mice with chronic local inflammation
    A Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
    Endocrinology 146:5128-34. 2005
    ..In conclusion, local inflammation strongly induces D3 activity in inflammatory cells, especially in invading polymorphonuclear granulocytes, suggesting enhanced local degradation of T(3)...
  37. pmc Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
    Monica Dentice
    Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, 80131 Naples, Italy, and Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:14466-71. 2007
    ..This previously unrecognized functional cross-talk between Shh/Gli2 and thyroid hormone in keratinocytes is a pathway by which Shh produces its proliferative effects and offers a potential therapeutic approach to BCC...
  38. ncbi Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis
    Arturo Hernandez
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Endocrinology 148:5680-7. 2007
    ..In conclusion, the absence of D3 activity results in impaired clearance of T(3) and significant defects in the mechanisms regulating the thyroid axis at all levels: hypothalamus, pituitary, and thyroid...
  39. pmc A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function
    Lily Ng
    National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Endocrinology Branch, Bethesda, Maryland 20892 1772, USA
    Endocrinology 150:1952-60. 2009
    ..We now report that type 3 deiodinase, a thyroid hormone-inactivating enzyme encoded by Dio3, is expressed in the immature cochlea before type 2 deiodinase...
  40. pmc Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors
    Lily Ng
    National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Endocrinology Branch, Bethesda, Maryland 20892 1772, USA
    J Neurosci 30:3347-57. 2010
    ..Type 3 deiodinase, encoded by Dio3, is expressed in the immature mouse retina...
  41. pmc Thyroid hormone receptor α and regulation of type 3 deiodinase
    Olga Barca-Mayo
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Endocrinol 25:575-83. 2011
    ..T(3) stimulated the promoter activity of 1.5 kb 5'-flanking region of the human (h) DIO3 promoter in GH3 cells after cotransfection with hTRα but not with hTRβ...
  42. pmc Imprinted gene dosage is critical for the transition to independent life
    Marika Charalambous
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Cell Metab 15:209-21. 2012
    ..show that the imprinted delta-like homolog 1/preadipocyte factor (Dlk1/Pref1) and iodothyronine deiodinase type 3 (Dio3) functions converge on the development of brown fat at the transition to independent life...
  43. pmc Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice
    Cintia B Ueta
    Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Mol Endocrinol 26:809-18. 2012
    ..Here, we show that the D3 gene (Dio3) is a tissue-specific imprinted gene in the heart, and thus, heterozygous D3 knockout (HtzD3KO) mice constitute a ..
  44. pmc Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1
    Robin P Peeters
    Erasmus University Medical Center, Department of Internal Medicine, Dr Molewaterplein 50, Room Ee502, 3015 GE Rotterdam, The Netherlands
    Endocrinology 154:550-61. 2013
    ..We report that the thyroid hormone-inactivating type 3 deiodinase (encoded by Dio3) is expressed in the mouse cerebellum at embryonic and neonatal stages, suggesting a need to protect cerebellar ..
  45. pmc Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T₃in the mouse cerebral cortex
    Arturo Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Endocrinology 153:2919-28. 2012
    ..It also suggests that negatively and positively regulated genes do not have the same physiological significance or that their regulation by thyroid hormone obeys different paradigms at the molecular or cellular levels...
  46. pmc MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration
    Christine M Snyder
    Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, MA 02215, USA
    Development 140:31-42. 2013
    ..this process through its direct regulation of the largest known mammalian microRNA (miRNA) cluster, the Gtl2-Dio3 locus...
  47. doi Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion
    Harri Lempiäinen
    Discovery and Investigative Safety, Novartis Institutes for BioMedical Research, CH 4057 Basel, Switzerland
    Toxicol Sci 131:375-86. 2013
    ..revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various ..
  48. pmc Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon
    Julie Seibt
    IRIBHM Institute for Interdisciplinary Research, Universite Libre de Bruxelles ULB, Brussels, Belgium
    PLoS ONE 7:e48675. 2012
    ..This raises the possibility that the transcripts of this selective locus participate in the biological effects of proneural genes in the developing telencephalon...
  49. doi Cardiac expression of deiodinase type 3 (Dio3) following myocardial infarction is associated with the induction of a pluripotency microRNA signature from the Dlk1-Dio3 genomic region
    Rob Janssen
    Laboratory for Physiology, VU University Medical Center, v d Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Endocrinology 154:1973-8. 2013
    ..Unexpectedly, we found a set of 29 up-regulated miRNAs originating from the Dlk1-Dio3 genomic imprinted region, which has been identified as a hallmark of pluripotency and proliferation...
  50. doi Large induction of type III deiodinase expression after partial hepatectomy in the regenerating mouse and rat liver
    Monique H A Kester
    Department of Internal Medicine, Erasmus Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 150:540-5. 2009
    ..Our data suggest that D3 is important in the modulation of thyroid hormone levels in the regenerating liver, in which a decrease in cellular T3 permits an increase in proliferation...
  51. pmc The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion
    Mayrin C Medina
    Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Endocrinology 152:3717-27. 2011
    ..Embryonic and adult wild-type mice and Mice with targeted disruption of Dio3 gene (D3KO) as well as human fetal pancreas and adult islets were studied...
  52. ncbi Regulation of iodothyronine deiodinases in the Pax8-/- mouse model of congenital hypothyroidism
    Sonke Friedrichsen
    Max Planck Institut fur Experimentelle Endokrinologie, D 30625 Hannover, Germany
    Endocrinology 144:777-84. 2003
    ..In conclusion, these findings show dramatic age and thyroid state-dependent changes in the expression of deiodinases in central and peripheral tissues of mice during the first 3 wk of life...
  53. ncbi Expression of type 2 iodothyronine deiodinase in corticotropin-secreting mouse pituitary tumor cells is stimulated by glucocorticoid and corticotropin-releasing hormone
    Osamu Araki
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi 371 8511, Japan
    Endocrinology 144:4459-65. 2003
    ..These results suggest the previously unrecognized role of local thyroid hormone activation by D2 in the regulation of pituitary corticotrophs...
  54. ncbi Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes
    Stephane Labialle
    Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada
    Hum Mol Genet 17:15-26. 2008
    ..regulated the expression of only Mico1/Mico1os, whereas in the congenic mice its influence was spread onto Rtl1as, Dio3 and Dio3os, i.e...
  55. ncbi Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term
    Manabu Kawahara
    Department of Bioscience, Tokyo University of Agriculture, Setagaya Ku, Tokyo 156 8502, Japan
    FEBS Lett 581:5178-84. 2007
    ..Foetuses derived from ng(Deltach12)/fg BMEs were alive at E19.5 but could not survive further. Comparison with BMEs derived from Igf2+/- ng/fg genomes suggests that bi-allelic H19 expression might be involved in foetal development...
  56. pmc Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton
    Luciane P Capelo
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508 000, Brazil
    Bone 43:921-30. 2008
    ....
  57. doi Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection
    Anita Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 18:1095-103. 2008
    ..Our earlier studies showed that granulocytes express type 3 deiodinase (D3) when activated during a turpentine-induced abscess. We hypothesized that D3 expression by granulocytes may also occur during bacterial infection...
  58. pmc Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae
    Anita Boelen
    Department of Endocrinology and Metabolism, F5 165, Academic Medical Center, Amsterdam, The Netherlands
    Endocrinology 150:1984-90. 2009
    ..Our results suggest a protective role for D3 in the defense against acute bacterial infection, probably by reinforcing the microbial killing capacity of neutrophils...
  59. pmc At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1
    John P Hagan
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 4:e4352. 2009
    ..In mammals, imprinted genes are critical in numerous developmental and physiological processes. Aberrant imprinted gene expression is implicated in several diseases including Prader-Willi/Angelman syndromes and cancer...
  60. doi Long nuclear-retained non-coding RNAs and allele-specific higher-order chromatin organization at imprinted snoRNA gene arrays
    Patrice Vitali
    Universite de Toulouse, UPS Laboratoire de Biologie Moléculaire Eucaryote, F 31000 Toulouse, France
    J Cell Sci 123:70-83. 2010
    ..A similar allele-specific chromatin organization is documented for snoRNA gene arrays at the imprinted Dlk1-Dio3 domain...
  61. pmc Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
    Jessica A Hall
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 151:4573-82. 2010
    ..This discovery highlights the importance of deiodinase-controlled thyroid hormone signaling in BAT development, where it has important metabolic repercussions for energy homeostasis in adulthood...
  62. doi Left-ventricular remodeling after myocardial infarction is associated with a cardiomyocyte-specific hypothyroid condition
    Christine J Pol
    Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit University Medical Center, 1081 HV Amsterdam, The Netherlands
    Endocrinology 152:669-79. 2011
    ..In conclusion, pathological ventricular remodeling after MI in the mouse leads to high and stable induction of D3 activity in cardiomyocytes and a local hypothyroid condition...
  63. pmc Thyroid hormone promotes insulin-induced glucose uptake by enhancing Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytes
    Yi Lin
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126 0901, USA
    J Cell Physiol 226:2625-32. 2011
    ..Further, VAMP2 is essential for T3 to increase insulin-stimulated translocation of GLUT4 and subsequent uptake of glucose in adipocytes...

Research Grants1

  1. Regulation of Cellular Senescence by MEG3 RNA
    Yunli Zhou; Fiscal Year: 2007
    ..Therefore, another specific aim is to determine how MEGS activates p53. Whether MEG3 RNA activates p53 through repression of Mdm2 expression will be the focus of investigation. [unreadable] [unreadable] [unreadable] [unreadable]..