Dhrs3

Summary

Gene Symbol: Dhrs3
Description: dehydrogenase/reductase (SDR family) member 3
Alias: Rsdr1, retSDR1, short-chain dehydrogenase/reductase 3, retinal short-chain dehydrogenase/reductase 1
Species: mouse

Top Publications

  1. pmc The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development
    Sara E Billings
    1Department of Pharmacology and Toxicology, School of Pharmacy, 5060 Malott Hall, 1251 Wescoe Hall Dr, University of Kansas, Lawrence, KS 66045, USA
    FASEB J 27:4877-89. 2013
  2. pmc The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis
    Mark K Adams
    From the Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Biol Chem 289:14868-80. 2014
  3. pmc p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation
    Chad Deisenroth
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:28343-56. 2011
  4. ncbi Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal
    F Haeseleer
    Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington 98195 6485, USA
    J Biol Chem 273:21790-9. 1998
  5. ncbi Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2)
    D Bächner
    Gesellschaft fur Biotechnologische Forschung, Growth Factors and Receptors, Braunschweig, Germany
    Dev Dyn 213:398-411. 1998
  6. ncbi Identification of novel genes expressed during metanephric induction through single-cell library screening
    J M Abidari
    Scott Department of Urology, Department of Molecular and Human Genetics, and Department of Pediatrics, Baylor College of Medicine, and Texas Children s Hospital, Houston, Texas 77030, USA
    Kidney Int 57:2221-8. 2000

Scientific Experts

  • Alexander R Moise
  • Mark K Adams
  • Sara E Billings
  • Chad Deisenroth
  • Olga V Belyaeva
  • Lizhi Wu
  • Natalia Y Kedishvili
  • MAUREEN A KANE
  • Xiao Yan Pang
  • Paul A Trainor
  • Naomi E Butler Tjaden
  • Keely Pierzchalski
  • Aiwen Jin
  • Laura Tollini
  • Yanping Zhang
  • Yoko Itahana
  • J M Abidari
  • D Bächner
  • F Haeseleer
  • J R Lupski
  • N Katsanis
  • G Karsenty
  • E T Gonzales
  • K Inoue
  • A Hoffmann
  • L Lebioda
  • D Schroder
  • P Steinert
  • J C Saari
  • G Gross
  • J Lauber
  • N Betat
  • L Flohe
  • J Huang
  • K Palczewski
  • M Ahrens

Detail Information

Publications6

  1. pmc The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development
    Sara E Billings
    1Department of Pharmacology and Toxicology, School of Pharmacy, 5060 Malott Hall, 1251 Wescoe Hall Dr, University of Kansas, Lawrence, KS 66045, USA
    FASEB J 27:4877-89. 2013
    ..Herein, we investigate the role of the retinaldehyde reductase Dhrs3 in embryonic retinoid metabolism using a Dhrs3-deficient mouse...
  2. pmc The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis
    Mark K Adams
    From the Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Biol Chem 289:14868-80. 2014
    The retinoic acid-inducible dehydrogenase reductase 3 (DHRS3) is thought to function as a retinaldehyde reductase that controls the levels of all-trans-retinaldehyde, the immediate precursor for bioactive all-trans-retinoic acid...
  3. pmc p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation
    Chad Deisenroth
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:28343-56. 2011
    ..an effort to identify novel p53 target genes, a microarray approach was utilized to identify DHRS3 (also known as retSDR1) as a robust candidate gene...
  4. ncbi Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal
    F Haeseleer
    Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington 98195 6485, USA
    J Biol Chem 273:21790-9. 1998
    ..We report here the cloning of a dehydrogenase, retSDR1, that belongs to the short-chain dehydrogenase/reductase superfamily and localizes predominantly in cone ..
  5. ncbi Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2)
    D Bächner
    Gesellschaft fur Biotechnologische Forschung, Growth Factors and Receptors, Braunschweig, Germany
    Dev Dyn 213:398-411. 1998
    ..C3H10T1/2-progenitors, therefore, may serve as a legitimate model for the investigation of the Bmp-mediated events during mesenchymal differentiation...
  6. ncbi Identification of novel genes expressed during metanephric induction through single-cell library screening
    J M Abidari
    Scott Department of Urology, Department of Molecular and Human Genetics, and Department of Pediatrics, Baylor College of Medicine, and Texas Children s Hospital, Houston, Texas 77030, USA
    Kidney Int 57:2221-8. 2000
    ..These findings suggest that Bmp7 controls the expression of genes important for nephrogenesis, but the identity of these genes has remained largely undetermined...