Def6

Summary

Gene Symbol: Def6
Description: differentially expressed in FDCP 6
Alias: 2410003F05Rik, 6430538D02Rik, AV094905, Ibp, Slat, Slat2, Slat6, differentially expressed in FDCP 6, DEF-6, IRF-4-binding protein, IRF4-binding protein, SWAP-70-like adapter of T-cells
Species: mouse

Top Publications

  1. pmc Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases
    Qinzhong Chen
    Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Leukoc Biol 85:539-43. 2009
  2. ncbi SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells
    Yoshihiko Tanaka
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Immunity 18:403-14. 2003
  3. ncbi Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system
    Sanjay Gupta
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Hum Immunol 64:389-401. 2003
  4. pmc Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity
    Jessica C Fanzo
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 116:703-14. 2006
  5. ncbi Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system
    M Hotfilder
    Max Delbrück Laboratory in the MPG, Cologne, Germany
    Br J Haematol 106:335-44. 1999
  6. pmc Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation
    Stéphane Bécart
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 29:704-19. 2008
  7. pmc IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor
    Qinzhong Chen
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Immunity 29:899-911. 2008
  8. pmc SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis
    Ann J Canonigo-Balancio
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 183:7259-67. 2009
  9. pmc Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
    Partha S Biswas
    Department of Medicine, Columbia University, New York, New York, USA
    J Clin Invest 120:3280-95. 2010
  10. pmc SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling
    Stéphane Bécart
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 117:2164-75. 2007

Scientific Experts

  • Thomas Samson
  • Amnon Altman
  • Stéphane Bécart
  • Sanjay Gupta
  • Alessandra B Pernis
  • Camille Fos
  • Qinzhong Chen
  • Partha S Biswas
  • Sonia Feau
  • Ann J Canonigo-Balancio
  • Govind Bhagat
  • Ann J Canonigo Balancio
  • Marjorie Côte
  • Kirstin Worthmann
  • Bang Ung Youn
  • Barbara P Vistica
  • Yoshihiko Tanaka
  • Roslynn A Stirzaker
  • Harshini Mehta
  • Celine Charvet
  • Wen Yang
  • Jessica C Fanzo
  • Klaus Ley
  • Darren Boehning
  • Nacksung Kim
  • Yong Wook Park
  • Stephen P Schoenberger
  • Jongwon Lee
  • Michael Leitges
  • Inyoung Kim
  • Kabsun Kim
  • Mario Schiffer
  • Jang Bae Moon
  • Jung Ha Kim
  • Irini Tossidou
  • Tobias B Huber
  • Marcello Sestu
  • Hermann Haller
  • Beina Teng
  • Lindsey Nugent
  • Theresa T Lu
  • Cuiyan Tan
  • Rolf Jessberger
  • Varsha Kumar
  • Guangpu Shi
  • Igal Gery
  • Emily Chang
  • Li Song
  • James K Liao
  • Michael Glogauer
  • Thomas Prod'homme
  • K Mark Coggeshall
  • Partha Biswas
  • Caitlin E Sedwick
  • Paula Smith
  • M Hotfilder
  • Carl Ware
  • Wei Duan
  • Carl De Trez
  • Michael Croft
  • Ayesha Siddiq
  • Steven Greenberg
  • So Young Jang
  • Svetlana Lebedeva
  • Rika Kitamura
  • Akira Matsumoto
  • Chuanmin Hu
  • Yoav Altman
  • Andrea Lee
  • Paul J Bushway
  • Ilan Goldberg
  • Giorgio Cattoretti
  • Jessica Fanzo
  • Hiroki Tabata
  • Sooji Hong
  • Kun Bi
  • M A Cross
  • S Baxendale
  • F Sablitzky

Detail Information

Publications19

  1. pmc Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases
    Qinzhong Chen
    Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Leukoc Biol 85:539-43. 2009
    ..IFN regulatory factor-4-binding protein (IBP; which is encoded by the gene Def6) is a unique type of activator for Rac that plays a crucial role in TCR-mediated signaling and adaptive immune ..
  2. ncbi SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells
    Yoshihiko Tanaka
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Immunity 18:403-14. 2003
    We describe the isolation of a protein, SWAP-70-like adapter of T cells (SLAT), which is expressed at high levels in thymocytes and differentiated Th2 cells...
  3. ncbi Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system
    Sanjay Gupta
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Hum Immunol 64:389-401. 2003
    ..Here we report the molecular cloning of human IBP (IRF-4 binding protein), a new member of this novel family of GEFs. The IBP gene maps to human chromosome 6p21...
  4. pmc Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity
    Jessica C Fanzo
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 116:703-14. 2006
    IFN regulatory factor 4-binding (IRF-4-binding) protein (IBP) is a novel type of activator of Rho GTPases that is recruited to the immunological synapse upon TCR stimulation...
  5. ncbi Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system
    M Hotfilder
    Max Delbrück Laboratory in the MPG, Cologne, Germany
    Br J Haematol 106:335-44. 1999
    ..Def-3, which is down-regulated upon differentiation into granulocytes but expressed in progenitor cells and macrophages, defines a novel family of RNA binding proteins...
  6. pmc Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation
    Stéphane Bécart
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 29:704-19. 2008
    SWAP-70-like adaptor of T cells (SLAT) is a guanine nucleotide exchange factor for Rho GTPases that regulates the development of T helper 1 (Th1) and Th2 cell inflammatory responses by controlling the Ca(2+)-NFAT signaling pathway...
  7. pmc IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor
    Qinzhong Chen
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Immunity 29:899-911. 2008
    ..Here, we showed that mice deficient in a previously isolated protein, IBP (IRF-4-binding protein), rapidly developed rheumatoid arthritis-like joint disease and large-vessel vasculitis...
  8. pmc SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis
    Ann J Canonigo-Balancio
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 183:7259-67. 2009
    SWAP-70-like adapter of T cells (SLAT; also known as Def6) is a novel guanine nucleotide exchange factor for Rho GTPases that has been previously shown to play a role in CD4+ T cell activation and Th1/Th2 differentiation...
  9. pmc Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
    Partha S Biswas
    Department of Medicine, Columbia University, New York, New York, USA
    J Clin Invest 120:3280-95. 2010
    ....
  10. pmc SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling
    Stéphane Bécart
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 117:2164-75. 2007
    SWAP-70-like adapter of T cells (SLAT) is a novel guanine nucleotide exchange factor for Rho GTPases that is upregulated in Th2 cells, but whose physiological function is unclear...
  11. pmc SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1
    Marjorie Côte
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Cell Sci 128:4341-52. 2015
    SLAT (also known as DEF6) promotes T cell activation and differentiation by regulating NFAT-Ca(2+) signaling...
  12. pmc Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP₃ receptor 1 promotes Ca²⁺ signaling in T cells
    Camille Fos
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Sci Signal 7:ra93. 2014
    The guanine nucleotide exchange factor SLAT (SWAP-70-like adaptor of T cells) regulates T cell activation and differentiation by enabling Ca(2+) release from intracellular stores in response to stimulation of the T cell receptor (TCR)...
  13. doi Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι
    Kirstin Worthmann
    Division of Nephrology, Department of Medicine, Hannover Medical School, Hannover, Germany
    Am J Pathol 183:1945-59. 2013
    ....
  14. pmc SLAT negatively regulates RANKL-induced osteoclast differentiation
    Bang Ung Youn
    Department of Pharmacology, Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, 501 746, Korea
    Mol Cells 36:252-7. 2013
    ..Herein, we investigated the role of SWAP-70-like adapter of T cells (SLAT) in RANKL-induced osteoclastogenesis...
  15. pmc SLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU)
    Barbara P Vistica
    Laboratory of Immunology, National Eye Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Vis 18:1858-64. 2012
    SWAP 70-like adaptor of T cells (SLAT; aka Def6) is a recently discovered guanine nucleotide exchange factor for Rho guanosine triphosphate (GTP)ases that has been previously shown to play a role in cluster of differentiation(CD)4+ T cell ..
  16. pmc SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner
    Sonia Feau
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 190:174-83. 2013
    ..SWAP-70-like adapter of T cells (SLAT), also known as Def6, is a novel guanine nucleotide exchange factor for the Cdc42 GTPase and plays a role in CD4(+) ..
  17. pmc Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity
    Partha S Biswas
    Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA
    J Exp Med 209:581-96. 2012
    ..IRF4 function in T helper cells can be modulated by its interaction with regulatory protein DEF6, a molecule that shares a high degree of homology with only one other protein, SWAP-70...
  18. pmc Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages
    Harshini Mehta
    Program in Immunobiology and Cancer, Oklahoma Medical Research Foundation, and Department of Cell Biology, University of Oklahoma, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 284:11882-91. 2009
    b>SLAT (SWAP-70-like adaptor protein of T cells) is an adaptor protein expressed in cells of the hematopoietic system. SLAT interacts with and alters the function of small GTPase Rac1 in fibroblasts...
  19. ncbi Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation
    Thomas Samson
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 282:15730-42. 2007
    ..Thus, our data suggest a role for Def-6 in the fine regulation of Rac1 during myogenesis with the integrin alpha7A chain guiding this regulation in a spatio-temporal manner...