DEC2

Summary

Gene Symbol: DEC2
Description: basic helix-loop-helix family, member e41
Alias: 6430520M22Rik, Bhlhb2l, Bhlhb3, DEC2, Sharp1, class E basic helix-loop-helix protein 41, bHLH transcriptional factor Dec2, basic helix-loop-helix domain containing, class B3, class B basic helix-loop-helix protein 3, differentially expressed in chondrocytes protein 2
Species: mouse

Top Publications

  1. ncbi 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation
    Jun Kondo
    Department of Pathology, Hirosaki University School of Medicine, Japan
    Int J Mol Med 17:1053-6. 2006
  2. ncbi Embryonic expression of mSharp-1/mDEC2, which encodes a basic helix-loop-helix transcription factor
    Sameena Azmi
    Department of Biochemisty and Molecular Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 114:181-5. 2002
  3. doi Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity
    Brid Bode
    Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    J Biol Rhythms 26:530-40. 2011
  4. doi Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice
    Brid Bode
    Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Chronobiol Int 28:737-50. 2011
  5. pmc Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
    Xuexian O Yang
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1260-6. 2009
  6. pmc The transcriptional repressor DEC2 regulates sleep length in mammals
    Ying He
    Department of Neurology, University of California at San Francisco, Mission Bay, 1550 Fourth Street, San Francisco, CA 94158, USA
    Science 325:866-70. 2009
  7. pmc SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP
    Neriman Tuba Gulbagci
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    EMBO Rep 10:79-86. 2009
  8. pmc Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice
    Moritz J Rossner
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 3:e2762. 2008
  9. pmc DEC1 modulates the circadian phase of clock gene expression
    Ayumu Nakashima
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Mol Cell Biol 28:4080-92. 2008
  10. ncbi Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements
    Katsumi Fujimoto
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Int J Mol Med 19:925-32. 2007

Scientific Experts

  • Kazuya Yamada
  • Moritz J Rossner
  • Fuyuki Sato
  • Takeshi Kawamoto
  • Katsumi Fujimoto
  • Yukio Kato
  • Mitsuhide Noshiro
  • Reshma Taneja
  • Sato Honma
  • Brid Bode
  • Ali Shahmoradi
  • Henrik Oster
  • Ken ichi Honma
  • Sameena Azmi
  • Ayumu Nakashima
  • Suma Gopinadhan
  • Neriman Tuba Gulbagci
  • Masae Furukawa
  • Zhiduo Liu
  • Paul C Baier
  • Masatoshi Suzuki
  • Sujata Acharjee
  • Akihiro Goriki
  • Bingting Liu
  • Shilpa Rani Shankar
  • Yaju Wang
  • Hidenori Hamaguchi
  • Noritsugu Ozaki
  • Anthony H Tsang
  • Belinda Mei Tze Ling
  • Teng Kai Chung
  • Li Li
  • Truc P T Pham
  • Ujjal K Bhawal
  • Jian Jun Liu
  • Xuexian O Yang
  • Ying He
  • Bing Sun
  • Yoshitake Cho
  • Fabienne Guillaumond
  • Kiyomasa K Honda
  • Hugues Dardente
  • Taichi Ueshima
  • Tomoyuki Iwata
  • Jun Kondo
  • Taizo Hamada
  • Matthew Preston Butler
  • Ryozo Nagai
  • Norihiko Takeda
  • Koji Maemura
  • Anne Ozog
  • Konstantin Radyushkin
  • Rong Cai
  • Takashi Todo
  • Jihwan Myung
  • Dongdong Li
  • Takashi Yoritaka
  • Wenhan Mei
  • Toru Takumi
  • Johannes Hirrlinger
  • Daniel Forger
  • Yong Zuo
  • Michael C Wehr
  • Takaya Abe
  • Tianshi Wang
  • Lisa Reinecke
  • Christina Kroos
  • Magdalena M Brzózka
  • Akio Matsubara
  • Jinke Cheng
  • Fumiyuki Hatanaka
  • Hiroshi Kiyonari
  • Shintaro Tanoue
  • Cécile Vercherat
  • Sven P Wichert
  • Jae Kyoung Kim
  • Kiyomasa Honda
  • Narendra Bharathy
  • Kotaro Tanimoto
  • K Fujimoto
  • Marta Garaulet
  • Wai Kay Kok
  • Kazuo Tanne
  • Pooja Gopal
  • Urara Fukuzaki-Dohi
  • Carmen Sánchez-Moreno
  • Jeongho Kwon
  • Jaekyoon Shin
  • Jiali Li
  • Charlie Xiang

Detail Information

Publications37

  1. ncbi 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation
    Jun Kondo
    Department of Pathology, Hirosaki University School of Medicine, Japan
    Int J Mol Med 17:1053-6. 2006
    The basic helix-loop-helix (bHLH) transcription factors, DEC2 and DEC1, play critical roles in the circadian rhythm of the suprachiasmatic nucleus (SCN)...
  2. ncbi Embryonic expression of mSharp-1/mDEC2, which encodes a basic helix-loop-helix transcription factor
    Sameena Azmi
    Department of Biochemisty and Molecular Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 114:181-5. 2002
    ..The diversity of its expression pattern suggests that mSharp-1 may regulate the differentiation of several cell types during vertebrate development...
  3. doi Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity
    Brid Bode
    Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    J Biol Rhythms 26:530-40. 2011
    ..An accessory loop involving the transcription factors DEC1 and DEC2 has been described that also impinges on CLOCK/BMAL1-mediated transactivation...
  4. doi Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice
    Brid Bode
    Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Chronobiol Int 28:737-50. 2011
    ..The basic helix-loop-helix transcription factors DEC1 (BHLHE40) and DEC2 (BHLHE41) can interact with this core TTL, forming an accessory feedback mechanism...
  5. pmc Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
    Xuexian O Yang
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1260-6. 2009
    ..Here we show that the basic helix-loop-helix transcription factor Dec2 was selectively expressed in T(H)2 cells...
  6. pmc The transcriptional repressor DEC2 regulates sleep length in mammals
    Ying He
    Department of Neurology, University of California at San Francisco, Mission Bay, 1550 Fourth Street, San Francisco, CA 94158, USA
    Science 325:866-70. 2009
    ..These mice represent a model of human sleep homeostasis that provides an opportunity to probe the effect of sleep on human physical and mental health...
  7. pmc SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP
    Neriman Tuba Gulbagci
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    EMBO Rep 10:79-86. 2009
    b>SHARP1, a basic helix-loop-helix transcription factor, is expressed in many cell types; however, the mechanisms by which it regulates cellular differentiation remain largely unknown...
  8. pmc Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice
    Moritz J Rossner
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 3:e2762. 2008
    ..However, the molecular mechanisms leading to the disintegration of tissue-specific clocks are complex and not well understood...
  9. pmc DEC1 modulates the circadian phase of clock gene expression
    Ayumu Nakashima
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Mol Cell Biol 28:4080-92. 2008
    ..Overexpression of Dec1 delayed the phase of clock genes such as Dec1, Dec2, Per1, and Dbp that contain E boxes in their regulatory regions, whereas it had little effect on the circadian ..
  10. ncbi Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements
    Katsumi Fujimoto
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Int J Mol Med 19:925-32. 2007
    b>Dec2, a member of the basic helix-loop-helix (bHLH) superfamily, has been shown to function as a transcriptional repressor and is implicated in cell proliferation and differentiation...
  11. ncbi Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1
    Fuyuki Sato
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Eur J Biochem 271:4409-19. 2004
    ..Moreover, mutant DEC1 also counteracted DEC2-mediated suppressive activity in a dominant-negative manner...
  12. ncbi Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors
    Sameena Azmi
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 279:52643-52. 2004
    ..Our data suggest that protein-protein interactions between Sharp-1, MyoD, and E47 resulting in interference with MyoD function underlies Sharp-1-mediated repression of myogenic differentiation...
  13. ncbi mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression
    Sameena Azmi
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 278:20098-109. 2003
    ..In this study, we have characterized the DNA-binding and transcriptional properties of the bHLH factor mSharp-1/DEC2. mSharp-1 belongs to the Hairy/Enhancer of Split subfamily of bHLH factors and exhibits the highest structural and ..
  14. doi Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Genes Cells 13:131-44. 2008
    DEC1 (BHLHB2/Sharp2/Stra13) and DEC2 (BHLHB3/Sharp1) are basic-helix-loop-helix (bHLH) transcription factors, involved in cellular differentiation, responses to hypoxia and circadian rhythms...
  15. ncbi Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins
    K Fujimoto
    Department of Biochemistry, Hiroshima University School of Dentistry, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Biochem Biophys Res Commun 280:164-71. 2001
    ..We report here the identification and characterization of human, mouse and rat DEC2, a novel member of the DEC subfamily...
  16. ncbi Dec1 and Dec2 are regulators of the mammalian molecular clock
    Sato Honma
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Nature 419:841-4. 2002
    ..We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 ..
  17. pmc Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex
    Ali Shahmoradi
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 112:E3582-9. 2015
    The bHLH transcription factors SHARP1 and SHARP2 are partially redundant modulators of the circadian system...
  18. doi The basic helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates Twist1 through an E-box element
    Masatoshi Suzuki
    Department of Anesthesiology, Nihon University School of Dentistry at Matsudo, Chiba 271 8587, Japan
    Biochem Biophys Res Commun 455:390-5. 2014
    Differentiated embryo chondrocyte 2 (DEC2/Sharp-1/Bhlhe41), a basic helix-loop-helix (bHLH) transcription factor, has been shown to regulate the transcription of target genes by binding to their E-box elements...
  19. pmc Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders
    Paul C Baier
    Department of Neurology, University of Kiel, Kiel, Germany Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    PLoS ONE 9:e110310. 2014
    ..The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC2/BHLHE40 has been shown ..
  20. pmc Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation
    Bingting Liu
    From the Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation and State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 289:22358-64. 2014
    ..SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1, which then releases Sharp-1 repression of PPARγ expression and adipocyte differentiation. These results reveal SENP1 as a novel regulator in adipogenesis. ..
  21. pmc A novel protein, CHRONO, functions as a core component of the mammalian circadian clock
    Akihiro Goriki
    RIKEN Brain Science Institute, Wako, Saitama, Japan Graduate School of Biomedical Sciences, Hiroshima University, Minami, Hiroshima, Japan
    PLoS Biol 12:e1001839. 2014
    ....
  22. doi Sharp-1 regulates TGF-β signaling and skeletal muscle regeneration
    Sujata Acharjee
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Cell Sci 127:599-608. 2014
    ..These results demonstrate that Sharp-1 regulates muscle regenerative capacity, at least in part, by modulation of TGF-β signaling. ..
  23. doi The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
    Yoshitake Cho
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Mol Pharmacol 76:1360-9. 2009
    The basic helix-loop-helix proteins differentiated embryo chondrocyte 1 (DEC1) and DEC2 are involved in circadian rhythm control...
  24. ncbi A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation
    Takeshi Kawamoto
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Biochem Biophys Res Commun 313:117-24. 2004
    ..a basic helix-loop-helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and DEC1 and DEC2 as well as PERs and CRYs suppressed the induced expression...
  25. doi Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2
    Truc P T Pham
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine and Samsung Biomedical Research Institute, Suwon Si, Kyonggi Do, Republic of Korea
    Biochem Biophys Res Commun 413:376-82. 2011
    ..study, we show that berberine up-regulated the expression of two different sets of C/EBP inhibitors, CHOP and DEC2, while down-modulating C/EBPα, PPARγ and other adipogenic markers and effectors in differentiating 3T3-L1 ..
  26. doi Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by RORα and their roles in adipogenesis
    Noritsugu Ozaki
    Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Genes Cells 17:109-21. 2012
    DEC1 and DEC2, members of the basic helix-loop-helix superfamily, are involved in various biological phenomena including clock systems, cell differentiation and metabolism...
  27. pmc G9a mediates Sharp-1-dependent inhibition of skeletal muscle differentiation
    Belinda Mei Tze Ling
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Mol Biol Cell 23:4778-85. 2012
    ..Our findings provide new insights into Sharp-1-dependent regulation of myogenesis and identify epigenetic mechanisms that could be targeted in myopathies characterized by elevated Sharp-1 levels...
  28. doi Tissue-specific interaction of Per1/2 and Dec2 in the regulation of fibroblast circadian rhythms
    Anthony H Tsang
    Circadian Rhythms Group, Gottingen, Germany
    J Biol Rhythms 27:478-89. 2012
    ..genetic interaction at the cellular level, we isolated fibroblasts from different tissues of Per1, Per2, and Dec2 single and double mutant mice...
  29. ncbi Molecular circadian rhythms in central and peripheral clocks in mammals
    Hugues Dardente
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, QC, Canada
    Chronobiol Int 24:195-213. 2007
    ....
  30. ncbi Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes
    Takeshi Kawamoto
    Department of Dental and Medical Biochemistry and Department of Prosthetic Dentistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553
    J Biochem 140:401-8. 2006
    ..clock systems, we examined the effect of fasting on circadian expression of clock genes including Dec1 and Dec2 in mice...
  31. ncbi Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli
    Kazuya Yamada
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Japan
    Front Biosci 10:3151-71. 2005
    ..BHLHB2 (also referred to as the DEC1/Eip1/SHARP-2/Stra13/Clast5) and BHLHB3 (also referred to as the DEC2/SHARP-1/SHARP1), are transcription factors that contain a unique orange domain...
  32. doi Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling
    Zhiduo Liu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Immunol 183:6320-9. 2009
    ..In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during ..
  33. pmc Sharp-1 modulates the cellular response to DNA damage
    Jian Jun Liu
    Department of Physiology, National University of Singapore, Singapore, Singapore
    FEBS Lett 584:619-24. 2010
    ..Our studies identify a novel function for Sharp-1 in cell cycle arrest and DNA damage-induced apoptosis. Inappropriate Sharp-1 expression may therefore be associated with tumorigenesis...
  34. ncbi Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice
    Matthew Preston Butler
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Rhythms 19:126-34. 2004
    DEC1 and DEC2 are basic helix-loop-helix transcription factors that functionally resemble negative feedback components of the mammalian circadian clock...
  35. pmc Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system
    Hidenori Hamaguchi
    Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Biochem J 382:43-50. 2004
    b>Dec2, a member of the basic helix-loop-helix superfamily, is a recently confirmed regulatory protein for the clockwork system...
  36. doi Altered Stra13 and Dec2 circadian gene expression in hypoxic cells
    Fabienne Guillaumond
    Universite de Nice Sophia Antipolis, CNRS FRE3094, 28 Av Valrose, 06108 Nice, France
    Biochem Biophys Res Commun 369:1184-9. 2008
    ..Here we show that Stra13 and Dec2, two circadian transcriptional regulators which play a crucial role in cell proliferation and apoptosis are ..
  37. ncbi Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice
    Mitsuhide Noshiro
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Biol Rhythms 20:404-18. 2005
    DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the ..