Genomes and Genes
Gene Symbol: Dct
Description: dopachrome tautomerase
Alias: TRP-2, TRP2, Tyrp-2, Tyrp2, slaty, slt, L-dopachrome tautomerase, DOPAchrome conversion factor, DOPAchrome isomerase, DOPAchrome oxidoreductase, L-dopachrome Delta-isomerase, SLATY locus protein, tyrosinase-related protein 2
Publications116 found, 100 shown here
- Functional properties of cloned melanogenic proteinsV J Hearing
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
Pigment Cell Res 5:264-70. 1992..They map to the albino, brown, and slaty loci in mice, and encode proteins with similar structures and features, but with distinct catalytic capacities...
- The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somitesP Soriano
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Development 124:2691-700. 1997..These results indicate that PDGFs may exert their functions during early embryogenesis by affecting cell survival and patterning...
- TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsB R Wong
The Rockefeller University, New York, New York 10021, USA
J Biol Chem 272:25190-4. 1997..These results suggest a role for this TNF-related ligand in the regulation of the T cell-dependent immune response...
- Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte developmentL Kos
Laboratory for Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
Pigment Cell Res 12:13-21. 1999..c. These results demonstrate that HGF/SF-MET signaling influences, but is not required for, the initial development of neural crest-derived melanocytes in vivo and in vitro...
- Tyrosinase gene expression in zebrafish embryosE Camp
Department of Molecular Biosciences Genetics, University of Adelaide, 5005 Adelaide, Australia
Dev Genes Evol 211:150-3. 2001..A wave of gene activation and cell migration is then observed moving towards the posterior of the animal. DOPA staining for tyrosinase activity shows the presence of active enzyme in embryos at least 3 h before visible pigmentation...
- Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutantC S Lee
Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
Dev Biol 236:17-29. 2001..This defect is specific to the ventral region of the RPE. Using molecular markers for RPE (Mi and Tyrp2) and NR (Math5), we demonstrate that there is a gradual loss of Mi and Tyrp2 expression and an appearance of Math5 ..
- Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomesAlexander C Theos
Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust, Cambridge CB2 2XY, United Kingdom
Mol Biol Cell 16:5356-72. 2005....
- TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factorK P Steel
MRC Institute of Hearing Research, University Park, Nottingham, UK
Development 115:1111-9. 1992....
- The role of Pax-6 in eye and nasal developmentJ C Grindley
Developmental Genetics Section, Western General Hospital, Edinburgh, UK
Development 121:1433-42. 1995....
- Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytesW J Pavan
Department of Molecular Biology, Princeton University, NJ 08544 1014
Proc Natl Acad Sci U S A 91:7159-63. 1994..The non-uniform distribution of melanoblasts in wild-type mice suggests that piebald acts stochastically to affect melanocyte development...
- Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper proteinC A Hodgkinson
Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
Cell 74:395-404. 1993..The multiple spontaneous and induced mutations available at mi provide a unique biological resource for studying the role of a bHLH-ZIP protein in mammalian development...
- Structure of the mouse tyrosinase-related protein-2/dopachrome tautomerase (Tyrp2/Dct) gene and sequence of two novel slaty allelesP S Budd
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
Genomics 29:35-43. 1995..exons and 5' and 3' flanking regions of the mouse tyrosinase-related protein-2 (dopachrome tautomerase) gene (Tyrp2/Dct), which is mutated in slaty mice...
- Tyrosinase and related proteins in mammalian pigmentationV del Marmol
LOCE, Institut J Bordet, Universite Libre de Bruxelles, Belgium
FEBS Lett 381:165-8. 1996..We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man...
- Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse modelE M Southard-Smith
Mouse Embryology Section, Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
Nat Genet 18:60-4. 1998..Our studies suggest that Sox10 is essential for proper peripheral nervous system development. We propose SOX10 as a candidate disease gene for individuals with HSCR whose disease does not have an identified genetic origin...
- Otx1 and Otx2 activities are required for the normal development of the mouse inner earH Morsli
National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
Development 126:2335-43. 1999..These results suggest that both Otx genes play important and differing roles in the morphogenesis of the mouse inner ear and the development of its sensory organs...
- Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissuesS Zhao
Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
Dev Biol 216:154-63. 1999..we generated transgenic mice carrying the lacZ reporter gene linked to the tyrosinase-related protein 2 (TRP2) promoter...
- MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair folliclesS A Jordan
MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom
Dev Biol 225:424-36. 2000..We have utilised an organ culture for embryonic skin taken from Dct-lacZ transgenic mice...
- Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eyeR Ashery-Padan
Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
Genes Dev 14:2701-11. 2000....
- The transcription factor Sox10 is a key regulator of peripheral glial developmentS Britsch
Max Delbruck Center for Molecular Medicine, D 13122 Berlin, Germany
Genes Dev 15:66-78. 2001..Haploinsufficiency of Sox10 can thus cause pigmentation and megacolon defects, which are also observed in Sox10(Dom)/+ mice and in patients with Waardenburg-Hirschsprung disease caused by heterozygous SOX10 mutations...
- Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomeraseS B Potterf
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Dev Biol 237:245-57. 2001..for the Sox10(Dom) mutation entirely lack neural crest-derived cells expressing the lineage marker KIT, MITF, or DCT. Moreover, neural crest cell cultures derived from homozygous embryos do not give rise to pigmented cells...
- Expression of Cre recombinase in pigment cellsLaurence Guyonneau
ISREC Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Pigment Cell Res 15:305-9. 2002..A construct was generated where Cre recombinase is controlled by the promoter of the mouse dopachrome tautomerase (Dct) gene. The construct was functionally tested in vitro and introduced into mice...
- The oculocutaneous albinism type IV gene Matp is a new marker of pigment cell precursors during mouse embryonic developmentLaura L Baxter
Mouse Embryology Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 49, Convent Drive, Building 49, Room 4A82, Bethesda, MD 20892 4472, USA
Mech Dev 116:209-12. 2002..membrane-associated transporter protein (MATP) varied similarly to the melanogenic enzymes dopachrome tautomerase (DCT) and tyrosinase related protein 1 (TYRP1) (Proc. Natl Acad. Sci. USA (2002) in press)...
- Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4Gertrude E Costin
Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Sci 116:3203-12. 2003..dark vesicles that contain tyrosinase and two other melanogenic enzymes, Tyrp1 (tyrosinase-related protein 1) and Dct (DOPAchrome tautomerase); this secretory process is not seen in wild-type melanocytes...
- Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine developmentLaura L Baxter
Mouse Embryology Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Gene Expr Patterns 3:703-7. 2003..Pmel17 expression in dorsal regions precedes dopachrome tautomerase (Dct) ISH expression, suggesting Pmel17 identifies melanoblasts at an earlier developmental stage...
- Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytesMark Oliver Trowe
Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Development 135:1725-34. 2008....
- Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progressionAng Li
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Dev Cell 21:722-34. 2011..Myosin contractility balances the extension of long pseudopods by effecting retraction and allowing force generation for movement through the complex 3D epidermal environment...
- A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomeraseK Tsukamoto
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
EMBO J 11:519-26. 1992..We now report that TRP-2 (tyrosinase related protein-2), which maps to and is mutated at the slaty locus in mice, encodes a protein with DOPAchrome tautomerase activity.
- Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouseJ Cable
MRC Institute of Hearing Research, University Park, Nottingham, UK
Mech Dev 50:139-50. 1995..These results suggest that mutations of the c-kit receptor tyrosine kinase encoded at the W locus do not alter early migration or differentiation of melanoblasts but severely affect melanoblasts survival...
- Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutantMichele Merves
Department of Pediatric Otolaryngology, Center for Hearing and Deafness Research, Cincinnati, OH 45229, USA
J Assoc Res Otolaryngol 4:264-75. 2003..These results suggest redundant or alternative mechanisms that likely regulate water homeostasis in the developing and mature inner ear...
- Melanocytes and pigmentation are affected in dopachrome tautomerase knockout miceLaurence Guyonneau
Molecular Oncology, Swiss Institute for Experimental Cancer Research, National Center of Competence in Research, 1066 Epalinges, Switzerland
Mol Cell Biol 24:3396-403. 2004..In comparison to the knockout, the slaty mutation (Dct(slt)/Dct(slt)) has less melanin and affects growth of primary melanocytes severely...
- Tyrosinase-related protein-2 and -1 are trafficked on distinct routes in B16 melanoma cellsGabriela Negroiu
Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, 060031 Bucharest 17, Romania
Biochem Biophys Res Commun 328:914-21. 2005..These data show that highly structural homologous glycoproteins use distinct trafficking pathways in the same cell...
- Altered melanocyte differentiation and retinal pigmented epithelium transdifferentiation induced by Mash1 expression in pigment cell precursorsJessica L Lanning
Department of Dermatology, Henry Ford Health System, Detroit, Michigan, USA
J Invest Dermatol 125:805-17. 2005..factor Mash1 was expressed early in pigment cell development in transgenic mice from the dopachrome tautomerase (Dct) promoter. Dct:Mash1 transgenic founders exhibit variable microphthalmia and patchy coat color hypopigmentation...
- Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cellsB Bouchard
Institut National de la Sante et de la Recherche Medicale, Service Dermatologie, Paris, France
Eur J Biochem 219:127-34. 1994..b>TYRP2 has been mapped to the chromosomal region 13q32, thus extending a region of synteny with mouse-chromosome 14.
- Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomeraseF Solano
Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Spain
Biochem J 313:447-53. 1996..This enzyme, also named TRP2, belongs to a family of three metalloenzymes termed the tyrosinase-related proteins (TRPs)...
- Ectopic c-kit expression affects the fate of melanocyte precursors in Patch mutant embryosB Wehrle-Haller
Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
Dev Biol 177:463-74. 1996....
- Wnt signalling required for expansion of neural crest and CNS progenitorsM Ikeya
Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
Nature 389:966-70. 1997..Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS...
- Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosisT Kunisada
Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Japan
Mech Dev 94:67-78. 2000..Loss of E-cadherin expression in dermal melanocyte precursors suggests that HGF caused dermal localization of melanocytes and their precursors by down-regulation of E-cadherin molecules...
- The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursorsHyung Ok Lee
Cell and Developmental Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Dev Biol 259:162-75. 2003..Rather, the EDNRB-mediated signaling is required for the terminal migration of melanoblasts and ENS precursors, and this pathway is not required for the survival of the migratory cells...
- Complementary expression patterns of retinoid acid-synthesizing and -metabolizing enzymes in pre-natal mouse inner ear structuresRaymond Romand
Institut Clinique de la Souris, 1, rue Laurent Fries, B P 10142, 67404 Illkirch, France
Gene Expr Patterns 4:123-33. 2004....
- Pax3 functions at a nodal point in melanocyte stem cell differentiationDeborah Lang
Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nature 433:884-7. 2005..Thus, a stem cell transcription factor can both determine cell fate and simultaneously maintain an undifferentiated state, leaving a cell poised to differentiate in response to external stimuli...
- Multiple requirements for Hes 1 during early eye formationHae Young Lee
Department of Pediatrics, Northwestern University Medical School at Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
Dev Biol 284:464-78. 2005..Together, these studies demonstrate that Hes1, like Pax6, simultaneously regulates multiple developmental processes during optic development...
- Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesisTae Inoue-Narita
Department of Dermatology, Akita University School of Medicine, Akita, Japan
Cancer Res 68:5760-8. 2008..Our results show that Pten is important for the maintenance of melanocyte stem cells and the suppression of melanomagenesis...
- Comparison of melanoblast expression patterns identifies distinct classes of genesStacie K Loftus
National Institutes of Health, National Human Genome Research Institute, Genetic Disease Research Branch, Bethesda, MD, USA
Pigment Cell Melanoma Res 22:611-22. 2009....
- The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell developmentKatja S Grossmann
Neuroscience Department, Department of Cancer Research, Department of Cardiovascular Research, Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
Proc Natl Acad Sci U S A 106:16704-9. 2009..Together, our genetic and biochemical analyses demonstrate that Shp2 is an essential component in the transduction of Nrg1/ErbB signals...
- Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: implication for skin photoprotection against UVA radiationShan Jiang
Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Free Radic Biol Med 48:1144-51. 2010Dopachrome tautomerase (Dct) is a critical enzyme in the melanogenesis pathway that isomerizes the intermediate dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and influences the proportion of DHICA monomer incorporated into ..
- Purification and N-glycosylation analysis of melanoma antigen dopachrome tautomeraseChristopher J Vavricka
Department of Biochemistry, Virginia Tech, 111 Engel Hall, West Campus Drive, Blacksburg, VA 24061, USA
Protein J 29:204-12. 2010Dopachrome tautomerase (DCT) plays a critical role in lowering the oxidative stress resulting from melanogenesis. Levels of DCT are elevated in melanoma cell lines that are especially resistant to chemotherapy and radiation...
- The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytesDebra L Silver
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Dev Biol 375:172-81. 2013..Together our findings indicate that Magoh-regulated proliferation of melanoblasts in the dermis may be critical for production of epidermally-bound melanoblasts. Our results point to a central role for Magoh in melanocyte development...
- A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cellsErez Nitzan
Department of Medical Neurobiology, IMRIC and ELSC, Hebrew University, Hadassah Medical School, Jerusalem 91120, PO Box 12272, Israel
Development 140:2269-79. 2013..Their timely downregulation in the dorsal neural tube is thus necessary for the switch between neural and melanocytic phases of NC development...
- Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligoS You
Laboratory of Immunology and Infectious Diseases, KAIST, Daejeon, Republic of Korea
Clin Exp Immunol 174:38-44. 2013..by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (TRP2)-180 (SVYDFFVWL) peptide, lipopolysaccharides and cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides...
- Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse modelKathryn A O'Donnell
Department of Molecular Biology and Genetics, and High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 110:E2706-13. 2013....
- Pax3 function is required specifically for inner ear structures with melanogenic fatesHongkyung Kim
Department of Anatomy, Yonsei University College of Medicine, Seoul 120 752, Republic of Korea
Biochem Biophys Res Commun 445:608-14. 2014..Consistently, the expression of Dct, a melanoblast marker, was also absent in the mutant inner ears. However, when examined at E11...
- Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progressionG Denecker
1 Unit of Molecular and Cellular Oncology, Inflammation Research Center, VIB, 9052 Ghent, Belgium 2 Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium
Cell Death Differ 21:1250-61. 2014..Moreover, our data are also relevant for human melanomagenesis as loss of ZEB2 expression is associated with reduced patient survival. ..
- Patterns of gene expression associated with Pten deficiency in the developing inner earHyung Jin Kim
Division of Intractable Diseases, Center for Biomedical Sciences, National Institute of Health, Chungcheongbuk Do, South Korea
PLoS ONE 9:e97544. 2014..From this study, we suggest two key regulatory signaling networks mediated by Spp1 and Rgs4, which may play potential roles in neuronal differentiation of developing auditory neurons. ..
- White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineageHitomi Aoki
Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
Genes Cells 20:439-49. 2015....
- A direct role for murine Cdx proteins in the trunk neural crest gene regulatory networkOraly Sanchez-Ferras
Molecular Genetics of Development Laboratory, Department of Biological Sciences and BioMed Research Center, University of Quebec at Montreal UQAM, Montreal H2X 3Y7, Canada
Development 143:1363-74. 2016....
- Regulation of mammalian melanogenesis. I: Partial purification and characterization of a dopachrome converting factor: dopachrome tautomeraseP Aroca
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Murcia, Spain
Biochim Biophys Acta 1035:266-75. 1990..1984) J. Invest. Dermatol. 83, 145-149) and the dopachrome conversion factor (Korner and Pawelek (1980) J. Invest. Dermatol...
- Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelaninM L Lamoreux
Department of Veterinary Pathobiology, Texas A and M University, College Station, USA
Pigment Cell Res 14:23-31. 2001..e., the albino (C) locus that encodes tyrosinase, the slaty (Slt) locus that encodes tyrosinase-related protein 2 (TRP2 also known as dopachrome tautomerase, DCT), the brown (..
- The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterizationY Hui
Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Biol Chem 276:47489-95. 2001..The identification of mCysLT(2)R will be useful for establishing CysLT(2)R-deficient mice and determining novel leukotriene functions...
- Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicleLan Ying Wu
Center for Craniofacial Molecular Biology, Division of Craniofacial Sciences and Therapeutics, School of Dentistry, Los Angeles, California 90033, USA
Invest Ophthalmol Vis Sci 44:2404-12. 2003..In the Msx1;Msx2, double mutant mouse, eye development arrests early in embryogenesis. To investigate possible functions of Msx2 in early ocular development, we created transgenic animals that overexpress Msx2...
- Neuroepithelial cells supply an initial transient wave of MSC differentiationYasuhiro Takashima
Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
Cell 129:1377-88. 2007..MSC recruitment from this pathway, however, is transient and is replaced by MSCs from unknown sources. We conclude that MSC can be defined as a definite in vivo entity recruited from multiple developmental origins...
- Functional characterization of melanocyte stem cells in hair folliclesSatomi Nishikawa-Torikai
Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Kobe, Japan
J Invest Dermatol 131:2358-67. 2011..Using Dct(tm1(Cre)Bee)/CAG-CAT-GFP mice, we show that, in the presence of stem cell factor and basic fibroblast growth factor ..
- NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared nicheChiung Ying Chang
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
Nature 495:98-102. 2013..Our findings reveal how melanocyte and hair follicle stem cell behaviours maintain reliance upon cooperative factors within the niche, and how this can be uncoupled in injury, stress and disease states...
- Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafnessAnnalisa Buniello
Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
PLoS ONE 8:e56274. 2013..We use Trp2 as a marker of melanoblasts migrating from the neural crest at E12...
- A cDNA encoding tyrosinase-related protein maps to the brown locus in mouseI J Jackson
Medical Research Council Clinical, Western General Hospital, Edinburgh, United Kingdom
Proc Natl Acad Sci U S A 85:4392-6. 1988..All b mutations in laboratory strains are associated with the same diagnostic Taq I fragment, suggesting that all derive from the same original mutation. I discuss possible function(s) of the tyrosinase-related protein...
- Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progressionS J Orlow
Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York 10016, USA
Proc Natl Acad Sci U S A 92:10152-6. 1995..within and among tumors in levels of mRNAs and proteins encoded by the wild-type alleles at the albino, brown, slaty, and silver loci...
- Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathwayB Wehrle-Haller
Institute of Neuroscience, University of Oregon, Eugene 97403
Development 121:731-42. 1995..In contrast, membrane-bound Steel factor appears to promote melanocyte precursor survival in the dermis...
- Cloning and analysis of gene regulation of a novel LPS-inducible cDNAC G Lee
Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
Immunogenetics 41:263-70. 1995..By interspecific back-cross analysis, Irg1 was mapped to mouse chromosome 14 linked to Tyrp2 and Rap2a. The IRG1 message appears 1...
- Dopachrome tautomerase is a zinc-containing enzymeF Solano
Dept of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Spain
Biochem Biophys Res Commun 204:1243-50. 1994..This enzyme, also named TRP2, belongs to the family of the tyrosinase related proteins...
- High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complexS J Orlow
Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York
J Invest Dermatol 103:196-201. 1994....
- Functional analysis of the slaty gene product (TRP2) as dopachrome tautomerase and the effect of a point mutation on its catalytic functionG Kroumpouzos
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
Biochem Biophys Res Commun 202:1060-8. 1994..Recently, a gene encoding a homologue of the melanogenic enzyme tyrosinase (termed tyrosinase related protein 2 or TRP2) was cloned and was subsequently mapped to the slaty locus on chromosome 14...
- Assignment of the tyrosinase-related protein-2 gene (TYRP2) to human chromosome 13q31-q32 by fluorescence in situ hybridization: extended synteny with mouse chromosome 14R A Sturm
Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia
Genomics 21:293-6. 1994
- Fine structure mapping and deletion analysis of the murine piebald locusD L Metallinos
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544
Genetics 136:217-23. 1994..Two anchor loci of chromosome 14, slaty and hypogonadal, in addition to simple sequence length repeat markers, were used to localize s to a 2-cM interval ..
- Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentialsT Ishiguro
Laboratory of Biomedical Research, University of Tokyo, Japan
Cancer Res 56:875-9. 1996..TI-241 may regulate the expression of various genes as a transcription factor in the complex process of metastasis...
- Tyrosinase-related protein-2 (DCT; TYRP2) maps to bovine chromosome 12G A Hawkins
DNA Research and Testing Laboratory, ABS Global, Inc, DeForest, Wisconsin 53532, USA
Mamm Genome 7:474-5. 1996
- The genetics of pigmentation: from fancy genes to complex traitsG S Barsh
Department of Pediatrics, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5428, USA
Trends Genet 12:299-305. 1996..Recent developments show that homologous genes in humans are responsible not only for rare diseases, such as albinism and piebaldism, but also for common phenotypic variations, such as red hair and fair skin...
- Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryosF Bernex
URA INRA de Génétique Moleculaire, Ecole Nationale Veterinaire d Alfort, Maisons Alfort, France
Development 122:3023-33. 1996..Nevertheless, we assume that the Kit/SCF pathway could be involved in the growth of transformed endothelial, epithelial and endocrine cells...
- Comparative linkage mapping of human chromosome 13 and bovine chromosome 12H S Sun
Department of Animal Sciences, University of Wisconsin, Madison 53706, USA
Genomics 39:47-54. 1997..One intrachromosomal rearrangement was detected in this linkage group relative to human, and this rearrangement was confirmed by fluorescence in situ hybridization results...
- Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factorK Opdecamp
Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Development 124:2377-86. 1997..In the trunk region of wild-type embryos, Mitf-expressing cells that coexpressed the melanoblast marker Dct and the tyrosine kinase receptor Kit were found in the dorsolateral neural crest migration pathway...
- Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differentlyA Nakayama
Laboratory of Developmental Neurogenetics, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Mech Dev 70:155-66. 1998..In wild type embryos, Mitf expression in neuropithelium and neural crest precedes that of the melanoblast marker Dct, is then co-expressed with Dct, and gradually fades away except in cells in hair follicles...
- Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant miceB Wehrle-Haller
Department of Pathology, Centre Medical Universitaire, 1, rue Michel Servet, Geneva 4, 1211, Switzerland
Dev Biol 210:71-86. 1999....
- Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survivalB Wehrle-Haller
Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403 1254, USA
Dev Biol 232:471-83. 2001..We further suggest that the MGF mediates MP migration through a signaling pathway that does not involve RAS...
- Specific expression of the retinoic acid-synthesizing enzyme RALDH2 during mouse inner ear developmentR Romand
Laboratoire de Neurobiologie, Universite Blaise Pascal, 63177 Cedex, Aubiere, France
Mech Dev 106:185-9. 2001..Raldh2 mesenchymal expression did not correlate with migrating neural crest-derived melanoblasts. These restricted expression domains may correspond to specific sites of RA synthesis during inner ear morphogenesis...
- Mutation of melanosome protein RAB38 in chocolate miceStacie K Loftus
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:4471-6. 2002..This study demonstrates the utility of expression profile analysis to identify mammalian disease genes...
- A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutationCherie Rao
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02476, USA
Development 130:4665-72. 2003..elegans. Our results suggest that the role of ADAMTS proteases in the regulation of cell migration has been conserved in mammalian development...
- Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanomaArlo J Miller
Dana Farber Cancer Institute and Children s Hospital, Department of Pediatric Hematology Oncology, Boston, Massachusetts, USA
Cancer Res 64:509-16. 2004..These studies identify MITF as a major transcriptional regulator of TRPM1 and suggest that its prognostic value may be linked to MITF-mediated regulation of cellular differentiation...
- The role of Pax2 in mouse inner ear developmentQuianna Burton
National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Dev Biol 272:161-75. 2004....
- Requirement for Mab21l2 during development of murine retina and ventral body wallRyuichi Yamada
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, 630 0101, Japan
Dev Biol 274:295-307. 2004..Our results reveal that Mab21l2 plays crucial roles in retina and in ventral body wall formation...
- Vax genes ventralize the embryonic eyeStina H Mui
Molecular Neurobiology Laboratory, The Salk Institute La Jolla, California 92037, USA
Genes Dev 19:1249-59. 2005....
- Molecular mechanisms underlying inner ear patterning defects in kreisler mutantsDaniel Choo
Department of Otolaryngology Head and Neck Surgery, Center for Hearing and Deafness Research, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, OH 45229 3039, USA
Dev Biol 289:308-17. 2006..The data also identify Gbx2, Dlx5, Wnt2b and Otx2 as key otic genes ultimately affected by perturbation of the kr/mafB-hindbrain pathway...
- Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferationZhongxian Jiao
Department of Neurology, Henry Ford Health Sciences Center, 2799 West Grand Boulevard, Detroit, MI 48202, USA
Dev Biol 296:396-408. 2006DOPAchrome tautomerase (Dct) functions downstream of tyrosinase in the biosynthetic pathway of eumelanin by catalyzing the conversion of dopachrome to 5,5-dihydroxyindole-2-carboxylic acid (DHICA) in pigment cells...
- The slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytesTomohisa Hirobe
Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
Pigment Cell Res 19:454-9. 2006The slaty (Dct(slt)) mutation is known to reduce the activity of dopachrome tautomerase in melanocytes and to reduce the melanin content in skin, hairs and eyes...
- Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndromeTom Van de Putte
Laboratory of Molecular Biology Celgen, KULeuven, Herestraat 49, B 3000 Leuven, Belgium
Hum Mol Genet 16:1423-36. 2007....
- Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty miceTomohisa Hirobe
Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
Anat Rec (Hoboken) 290:981-93. 2007The slaty (Dct(slt)) mutation is known to reduce the activity of dopachrome tautomerase, which converts dopachrome to 5,6-dihydroxyindole-2-carboxylic acid in the pathway of eumelanin synthesis and to inhibit melanosome maturation in ..
- High levels of melanin-related metabolites in plasma from pink-eyed dilution miceKazumasa Wakamatsu
Pigment Cell Res 20:222-4. 2007
- Timeline and distribution of melanocyte precursors in the mouse heartFlavia Carneiro Brito
Department of Biological Sciences, Florida International University, Miami, Florida 33199, USA
Pigment Cell Melanoma Res 21:464-70. 2008..In this study, we tracked cardiac melanoblasts using in situ hybridization with a dopachrome tautomerase (Dct) probe and Dct-LacZ transgenic mice...
- The transcription factor Sox5 modulates Sox10 function during melanocyte developmentC Claus Stolt
Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
Nucleic Acids Res 36:5427-40. 2008..Both binding site competition and recruitment of corepressors thus help Sox5 to modulate the activity of Sox10 in the melanocyte lineage...
- NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferationKristina Buac
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Pigment Cell Melanoma Res 22:773-84. 2009..We propose that targeting ERBB3 activation and downstream genes identified in this study may provide novel therapeutic interventions for malignant melanoma...
- Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skinIgor Adameyko
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
Cell 139:366-79. 2009..These results reveal SCPs as a cellular origin of melanocytes, and have broad implications on the molecular mechanisms regulating skin pigmentation during development, in health and pigmentation disorders...
- Key roles for transforming growth factor beta in melanocyte stem cell maintenanceEmi K Nishimura
Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
Cell Stem Cell 6:130-40. 2010..These data demonstrate that the TGF-beta signaling pathway is one of the key niche factors that regulate melanocyte stem cell immaturity and quiescence...
- Hair follicle stem cells provide a functional niche for melanocyte stem cellsShintaro Tanimura
Department of Stem Cell Medicine, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
Cell Stem Cell 8:177-87. 2011....
- The developmental role of Agouti in color pattern evolutionMarie Manceau
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Science 331:1062-5. 2011..Thus, natural selection favors late-acting, tissue-specific changes in embryonic Agouti expression to produce large changes in adult color pattern...
- REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTSGregory Barsh; Fiscal Year: 2003..abstract_text> ..
- Molecular Development of the Endolymphatic Duct and SacDaniel Choo; Fiscal Year: 2005..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
- Genetics of Dark Skin in MiceGregory Barsh; Fiscal Year: 2006..unreadable] [unreadable]..
- Attractin and Mahoganoid in Spongy NeurodegenerationGregory Barsh; Fiscal Year: 2007..Investigating the biochemical, cellular, and genetic relationships between Atrn, Mahoganoid, and PrP is likely to provide general insight into the pathogenesis of spongy degeneration. [unreadable] [unreadable]..