Dcn

Summary

Gene Symbol: Dcn
Description: decorin
Alias: DSPG2, PG40, PGII, PGS2, SLRR1B, decorin, bone proteoglycan II
Species: mouse

Top Publications

  1. ncbi Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration
    R Merline
    Pharmazentrum frankfurt ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt am Main, Germany
    J Physiol Pharmacol 60:5-13. 2009
  2. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
  3. pmc The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis
    Oliver Jungmann
    Insitute of Physiological Chemistry and Pathobiochemistry, University Hospital Munster, Munster, Germany
    PLoS ONE 7:e50809. 2012
  4. pmc Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
    K G Danielson
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 136:729-43. 1997
  5. pmc Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis
    R V Iozzo
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:3092-7. 1999
  6. ncbi A role for decorin in the structural organization of periodontal ligament
    L Hakkinen
    Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    Lab Invest 80:1869-80. 2000
  7. pmc Resistance to Lyme disease in decorin-deficient mice
    E L Brown
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030, USA
    J Clin Invest 107:845-52. 2001
  8. ncbi Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues
    A Corsi
    Department of Experimental Medicine, Universita dell Aquila, Italy
    J Bone Miner Res 17:1180-9. 2002
  9. ncbi Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Reproduction 125:585-95. 2003
  10. ncbi The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, SP Brazil
    Cell Mol Biol (Noisy-le-grand) 49:673-8. 2003

Research Grants

  1. ROLE OF MGRB10 IN IGF-I INDUCED SIGNALING
    Andrea Morrione; Fiscal Year: 2002
  2. Proepithelin Signaling in Urothelial Cells
    Andrea Morrione; Fiscal Year: 2009

Scientific Experts

  • Daniela G Seidler
  • Andrea Morrione
  • Ayman Al Haj Zen
  • R V Iozzo
  • Sara M Weis
  • P M Coan
  • Sunil Wadhwa
  • Liliana Schaefer
  • E L Brown
  • Lisa Shaw
  • L Hakkinen
  • Elke Schonherr
  • Telma Mt Zorn
  • Shoujun Chen
  • David E Birk
  • Enrique Brandan
  • Kornélia Baghy
  • Claudio Cabello-Verrugio
  • Zhiping Wu
  • Rick T Owens
  • Xiuli Bi
  • Zsolt Horvath
  • Guiyun Zhang
  • Ilona Kovalszky
  • Zsuzsa Schaff
  • Oliver Jungmann
  • Christian Stock
  • Louis J Soslowsky
  • Mara S Ludwig
  • Marian F Young
  • S San Martin
  • Javier Barallobre-Barreiro
  • Maria A Gubbiotti
  • J A Gordon
  • Ambart E C Covarrubias
  • Tadanori Mammoto
  • Koshiro Ueda
  • Andrew A Dunkman
  • Katalin Kiss
  • Michael J Mienaltowski
  • Carla Bocian
  • Young Hyun You
  • Beatrice E Lechner
  • Alexandra Fullár
  • Katherine A Fantauzzo
  • LeAnn M Dourte
  • Winston W Y Kao
  • Michiko Ichii
  • Jean Denis Bénazet
  • Dwi U Kemaladewi
  • Mei Sun
  • Marta Benet
  • Giorgio Giacomo Galli
  • Cinzia L Marchica
  • K P Goetsch
  • Rosetta Merline
  • Emi Hiroki
  • M Ward
  • David P Beason
  • Wancai Yang
  • Yanjun Gu
  • Yoshiaki Ito
  • Wenjin Liu
  • Grace Guzman
  • Kumar Sharma
  • Tsuyoshi Hikake
  • Yuxiang Zhang
  • Naoto Haruyama
  • Kentaro Araki
  • Valentina Pinelli
  • R Merline
  • Yoshiyuki Mochida
  • Anne Gabory
  • Susan M Faust
  • Zishu Pan
  • Yasuhiro Kishioka
  • Cristian Santander
  • Francesco G Salerno
  • Jinhong Zhu
  • Stefano Biressi
  • Claus Rühland
  • Kevin Jon Williams
  • Adam S Raefski
  • Rebeca Droguett
  • K G Danielson
  • David J McQuillan
  • Manoranjan Santra
  • Jaime Gutierrez
  • Millicent M Sullivan
  • Yanming Bi

Detail Information

Publications104 found, 100 shown here

  1. ncbi Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration
    R Merline
    Pharmazentrum frankfurt ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt am Main, Germany
    J Physiol Pharmacol 60:5-13. 2009
    Although deficiency of the small leucine-rich proteoglycan decorin aggravates diabetic nephropathy in mice, the precise mechanisms of action are not fully understood...
  2. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  3. pmc The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis
    Oliver Jungmann
    Insitute of Physiological Chemistry and Pathobiochemistry, University Hospital Munster, Munster, Germany
    PLoS ONE 7:e50809. 2012
    b>Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling...
  4. pmc Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
    K G Danielson
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 136:729-43. 1997
    b>Decorin is a member of the expanding group of widely distributed small leucine-rich proteoglycans that are expected to play important functions in tissue assembly...
  5. pmc Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis
    R V Iozzo
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:3092-7. 1999
    Ectopic expression of decorin in a wide variety of transformed cells results in growth arrest and the inability to generate tumors in nude mice...
  6. ncbi A role for decorin in the structural organization of periodontal ligament
    L Hakkinen
    Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    Lab Invest 80:1869-80. 2000
    b>Decorin is a small leucine-rich proteoglycan that interacts with several matrix molecules, including various types of collagen and growth factors, and suppresses the growth of neoplastic cells by an epidermal growth factor (EGF) receptor-..
  7. pmc Resistance to Lyme disease in decorin-deficient mice
    E L Brown
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030, USA
    J Clin Invest 107:845-52. 2001
    ..BORRELIA: burgdorferi, the causative agent of Lyme disease (LD), expresses two surface-exposed decorin-binding adhesins, DbpA and DbpB...
  8. ncbi Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues
    A Corsi
    Department of Experimental Medicine, Universita dell Aquila, Italy
    J Bone Miner Res 17:1180-9. 2002
    b>Decorin (dcn) and biglycan (bgn), two members of the family of small leucine-rich proteoglycans (SLRPs), are the predominant proteoglycans expressed in skin and bone, respectively...
  9. ncbi Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Reproduction 125:585-95. 2003
    ..are important in the regulation of collagen fibrillogenesis, and the present study analysed four members (decorin, biglycan, lumican and fibromodulin) of the family of small leucine-rich proteoglycans (SLRPs) in the uterus from ..
  10. ncbi The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, SP Brazil
    Cell Mol Biol (Noisy-le-grand) 49:673-8. 2003
    ..is associated with the presence of thick collagen fibrils in decidualised regions of the endometrium and that decorin is associated exclusively with thin collagen fibrils in non-decidualised endometrial areas...
  11. pmc Protective niche for Borrelia burgdorferi to evade humoral immunity
    Fang Ting Liang
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Pathol 165:977-85. 2004
    ..B. burgdorferi expresses several ligand-binding lipoproteins, including the decorin-binding proteins (Dbps) A and B, which may mediate attachment to decorin, a major component of the host ..
  12. ncbi Decorin deficiency leads to impaired angiogenesis in injured mouse cornea
    Elke Schonherr
    Institute of Physiological Chemistry and Pathobiochemistry, University and University Hospital of Münster, Munster, Germany
    J Vasc Res 41:499-508. 2004
    ..We investigated consequences of the targeted ablation of decorin (DCN), biglycan (BGN) and fibromodulin (FMOD) genes on inflammation-induced angiogenesis in the cornea...
  13. ncbi A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival
    Daniela G Seidler
    Department of Physiological Chemistry and Pathobiochemistry, Waldeyerstr 15, University Hospital Munster, University of Munster, D 48149 Munster, Germany
    Biochem Biophys Res Commun 332:1162-70. 2005
    ..Proteoglycans, like decorin, affect these complex interactions...
  14. ncbi Decorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice
    Ayman Al Haj Zen
    Inserm EMI 0016, Rene Descartes Medical School Necker, University Paris 5, 156, rue de Vaugirard, 75015 Paris, France
    Atherosclerosis 187:31-9. 2006
    Atherosclerosis results from accumulation of macrophages and extracellular matrix in the arterial wall. Decorin, a small matrix proteoglycan, is able to regulate cell proliferation, migration and growth factors' activity...
  15. ncbi Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development
    Guiyun Zhang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biochem 98:1436-49. 2006
    ..Small leucine-rich proteoglycans have been implicated in the regulation of fibrillogenesis and decorin is the prototypic member of this family...
  16. pmc Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin
    Liliana Schaefer
    Departments of Internal Medicine D, University of Munster, Munster, Germany
    Am J Pathol 170:301-15. 2007
    b>Decorin, a small leucine-rich proteoglycan, affects the synthesis of the elastic fiber component fibrillin-1 in the kidney via hitherto unknown mechanisms...
  17. ncbi The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis
    Claus Rühland
    Department of Physiological Chemistry and Pathobiochemistry, University of Munster, Germany
    FEBS J 274:4246-55. 2007
    b>Decorin is a multifunctional small leucine-rich proteoglycan involved in the regulation of collagen fibrillogenesis...
  18. pmc Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation
    Xiuli Bi
    Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Carcinogenesis 29:1435-40. 2008
    b>Decorin is a member of the small leucine-rich proteoglycan gene family and plays an important role in suppressing cancer cell growth and metastasis...
  19. pmc Decorin modulates collagen matrix assembly and mineralization
    Yoshiyuki Mochida
    Dental Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, United States
    Matrix Biol 28:44-52. 2009
    b>Decorin (DCN) is one of the major matrix proteoglycans in bone...
  20. pmc Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan
    Guiyun Zhang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 284:8888-97. 2009
    b>Decorin and biglycan are class I small leucine-rich proteoglycans (SLRPs) involved in regulation of collagen fibril and matrix assembly...
  21. doi Decorin suppresses bone metastasis in a breast cancer cell line
    Kentaro Araki
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan
    Oncology 77:92-9. 2009
    b>Decorin, the prototype of an expanding family of small leucine-rich proteoglycans, is involved in a number of cellular processes including matrix assembly, fibrillogenesis and the control of cell proliferation...
  22. pmc Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice
    Kornélia Baghy
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Lab Invest 91:439-51. 2011
    Accumulation of connective tissue is a typical feature of chronic liver diseases. Decorin, a small leucine-rich proteoglycan, regulates collagen fibrillogenesis during development, and by directly blocking the bioactivity of transforming ..
  23. pmc A role for decorin in a murine model of allergen-induced asthma
    Cinzia L Marchica
    Meakins Christie Laboratories, McGill University Health Center, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 300:L863-73. 2011
    b>Decorin (Dcn) is an extracellular matrix proteoglycan, which affects airway mechanics, airway-parenchymal interdependence, airway smooth muscle proliferation and apoptosis, and transforming growth factor-β bioavailability...
  24. doi Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification
    Christian Stock
    Institute of Physiology II, Munster University, UKM, Munster, Germany
    J Cell Physiol 226:2641-50. 2011
    ..Time-lapse microscopy revealed that in B16V cells exposed to either decorin or chondroitin sulfates migration and invasion decreased by more than 50%...
  25. pmc The role for decorin in delayed-type hypersensitivity
    Daniela G Seidler
    Institute of Physiological Chemistry and Pathobiochemistry, D 48149 Munster, Germany
    J Immunol 187:6108-19. 2011
    b>Decorin, a small leucine-rich proteoglycan, regulates extracellular matrix organization, growth factor-mediated signaling, and cell growth...
  26. pmc Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21
    Rosetta Merline
    1Pharmazentrum Frankfurt, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Sci Signal 4:ra75. 2011
    ..Here, we show that the soluble form of the extracellular matrix proteoglycan decorin controls inflammation and tumor growth through PDCD4 (programmed cell death 4) and miR-21 (microRNA-21) by two ..
  27. pmc The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly
    Shoujun Chen
    Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33612 4799, USA
    FEBS J 280:2120-37. 2013
    ..SLRPs regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function...
  28. pmc Biglycan and decorin differentially regulate signaling in the fetal membranes
    Zhiping Wu
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA
    Matrix Biol 35:266-75. 2014
    ..Notably, a subtype of Ehlers-Danlos Syndrome is caused by expression of abnormal biglycan and decorin proteoglycans...
  29. ncbi The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin
    Enrique Brandan
    Centro de Regulación Celular y Patología Joaquín V Luco, CRCP, Departamento de Biologia Celular y Molecular, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Biol Chem 281:31562-71. 2006
    b>Decorin is a small leucine-rich proteoglycan that modulates the activity of transforming growth factor type beta and other growth factors and thereby influences the processes of proliferation and differentiation in a wide array of ..
  30. ncbi The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation
    T Scholzen
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    J Biol Chem 269:28270-81. 1994
    b>Decorin, a proteoglycan known to interact with collagen and growth factors, may play key roles during ontogenesis, tissue remodeling, and cancer...
  31. pmc Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury
    Liliana Schaefer
    Medizinische Klinik und Poliklinik D, Albert Schweitzer Str 33, 48149 Munster, Germany
    Am J Pathol 165:383-96. 2004
    There is growing evidence that the two small leucine-rich proteoglycans biglycan and decorin regulate the assembly of connective tissues and alter cell behavior during development and pathological processes...
  32. ncbi A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1
    Claudio Cabello-Verrugio
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad Millennium Institute for Fundamental and Applied Biology MIFAB, Pontificia Universidad Catolica de Chile, Casilla 114 D Santiago, Chile
    J Biol Chem 282:18842-50. 2007
    ..Here we describe two novel modulators of this pathway, lipoprotein-receptor related protein (LRP-1) and decorin. Decorin null (Dcn null) myoblasts showed a diminished TGF-beta response that is restored by decorin re-..
  33. doi H19 acts as a trans regulator of the imprinted gene network controlling growth in mice
    Anne Gabory
    Genetics and Development Department, INSERM U567, CNRS UMR 8104, University of Paris Descartes, Institut Cochin, Paris, France
    Development 136:3413-21. 2009
    ..Our results also bring further experimental evidence for the existence of the IGN and open new perspectives in the comprehension of the role of genomic imprinting in embryonic growth and in human imprinting pathologies...
  34. pmc Wild type N-ras displays anti-malignant properties, in part by downregulating decorin
    Marta Benet
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    J Cell Physiol 227:2341-51. 2012
    ..Through mRNA and microRNA (miRNAs) expression profiling we have identified genes (decorin) and miRNAs (mir-29A, let-7b) modulated by wt N-ras potentially responsible for the anti-malignant effect...
  35. pmc Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis
    Katherine A Fantauzzo
    Department of Dermatology, Columbia University, New York, NY 10032, USA
    Development 139:203-14. 2012
    ..Our findings identify Trps1 as a novel regulator of the Wnt signaling pathway and of early hair follicle progenitors in the developing vibrissa follicle...
  36. doi Cell-type specific regulation of myostatin signaling
    Dwi U Kemaladewi
    Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4 P, PO Box 9600, 2300RC, Leiden, The Netherlands
    FASEB J 26:1462-72. 2012
    ..Together, our results identify a molecular mechanism that explains the cell-type specific aspects of signaling by myostatin and other TGF-β family members...
  37. pmc Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition
    Zhiping Wu
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 7:e29627. 2012
    ..Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of reproductive tissues and muscle...
  38. pmc Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon
    LeAnn M Dourte
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104 6081, USA
    J Biomech Eng 134:031005. 2012
    ..b>Decorin content was varied in a dose dependent manner using decorin null, decorin heterozygote, and wild type mice...
  39. pmc Dichotomy of decorin activity on the insulin-like growth factor-I system
    Andrea Morrione
    Department of Urology and the Biology of Prostate Cancer Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    FEBS J 280:2138-49. 2013
    The stromal-specific proteoglycan decorin has emerged in recent years as a critical regulator of tumor initiation and progression...
  40. pmc The injury response of aged tendons in the absence of biglycan and decorin
    Andrew A Dunkman
    The McKay Orthopaedic Research Laboratory, University of Pennsylvania, 424 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104, USA
    Matrix Biol 35:232-8. 2014
    Recent studies have demonstrated that the small leucine-rich proteoglycans (SLRPs) biglycan and decorin impact tendon development, aging and healing in mature mice...
  41. pmc Decorin deficiency promotes hepatic carcinogenesis
    Zsolt Horvath
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Matrix Biol 35:194-205. 2014
    ..A key constituent for the hepatic microenvironment is the small leucine-rich proteoglycan decorin, known to interfere with cellular events of tumorigenesis mainly by blocking various receptor tyrosine kinases (..
  42. pmc Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation
    Tadanori Mammoto
    Vascular Biology Program, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts
    Dev Dyn 244:713-23. 2015
    ..However, the mechanism by which cell compaction is stabilized over time to ensure correct organ-specific cell fate switching remains unknown...
  43. doi The absence of the embryo in the pseudopregnant uterus alters the deposition of some ECM molecules during decidualization in mice
    Ambart E C Covarrubias
    Laboratory of Reproductive and Extracellular Matrix Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil and
    Connect Tissue Res 56:253-63. 2015
    ..induced in pseudopregnant Swiss mice, and the distribution of collagen types I, III, IV, V and the proteoglycans decorin and biglycan was investigated by immunolabeling from the fifth to the eighth day of pseudopregnancy...
  44. pmc Possible dual role of decorin in abdominal aortic aneurysm
    Koshiro Ueda
    Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, 755 8505, Japan
    PLoS ONE 10:e0120689. 2015
    ..b>Decorin, a small leucine-rich repeat proteoglycan, has been suggested to regulate inflammation and stabilize the ..
  45. pmc Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model
    J A Gordon
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA
    J Biomech 48:2110-5. 2015
    ..the mechanical and structural differences observed in mouse Achilles tendons lacking class I SLRPs; either decorin or biglycan...
  46. pmc Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy
    Maria A Gubbiotti
    Department of Pathology, Anatomy and Cell Biology, and the Cancer Cell Biology and Signaling Program, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Matrix Biol 48:14-25. 2015
    ..b>Decorin, a secreted proteoglycan, evokes autophagy in endothelial cells and mitophagy in breast carcinoma cells...
  47. pmc Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
    Javier Barallobre-Barreiro
    From King s British Heart Foundation Centre, King s College London, United Kingdom J B B, A Zoccarato, R K T, M F, X Y, A Zampetaki, M C, P W, A M S, K O, M M Institute for Molecular and Translational Therapeutic Strategies, MH Hannover, Germany S K G, T T St George s Hospital, NHS Trust, London, United Kingdom M F, A V, A K, M J University Medical Center Hamburg Eppendorf, Germany T W, M N H Protein Metrics, San Carlos, CA M B Biobanco A Coruña, INIBIC Complexo Hospitalario Universitario de A Coruña, Spain N D Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität Frankfurt, Frankfurt am Main, Germany L S Institute for Pharmacology and Clinical Pharmacology, Heinrich Heine University, Dusseldorf, MA 02115-6084
    Circulation 134:817-32. 2016
    ..Myocardial fibrosis is a feature of many cardiac diseases. We used proteomics to profile glycoproteins in the human cardiac extracellular matrix (ECM)...
  48. doi A comparative study of myostatin, follistatin and decorin expression in muscle of different origin
    Emi Hiroki
    Department of Anatomy, Tokyo Dental College, Masago, Mihama ku, Chiba City, Japan
    Anat Sci Int 86:151-9. 2011
    ..b>Decorin-a small leucine-rich proteoglycan-traps myostatin and modulates its activity towards myogenic cells in the ECM...
  49. pmc The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells
    Michiko Ichii
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 119:1683-92. 2012
    ..In contrast, the production of decorin, tenascins, and fibromodulin markedly increased...
  50. pmc Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice
    Xiuli Bi
    School of Life Sciences, Liaoning University, Shenyang 110036, China
    Carcinogenesis 33:326-30. 2012
    Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting ..
  51. pmc The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates transforming growth factor (TGF)-β-dependent signaling, and inhibits TGF-β-dependent fibrotic response in skeletal muscles
    Claudio Cabello-Verrugio
    Centro de Regulación Celular y Patología, Centro de Regeneración y Envejecimiento, Departamento de Biologia Celular y Molecular, Pontificia Universidad Catolica de Chile, Santiago
    J Biol Chem 287:6773-87. 2012
    b>Decorin is a small proteoglycan, composed of 12 leucine-rich repeats (LRRs) that modulates the activity of transforming growth factor type β (TGF-β) and other growth factors, and thereby influences proliferation and differentiation in ..
  52. pmc Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone
    Giorgio Giacomo Galli
    Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 8:e1002711. 2012
    ..Collectively, our results define a novel role for Prdm5 in sustaining the transcriptional program necessary to the proper assembly of osteoblastic extracellular matrix...
  53. doi Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland
    Development 139:4250-60. 2012
    ..In summary, our analysis reveals that SMAD4 is required to initiate: (1) formation of the Sox9-positive digit ray primordia; and (2) aggregation and chondrogenic differentiation of all limb skeletal elements...
  54. pmc Role of Nox2 in diabetic kidney disease
    Young Hyun You
    Center for Renal Translational Medicine, Division of Nephrology Hypertension, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Am J Physiol Renal Physiol 304:F840-8. 2013
    ..The present results demonstrate that lack of Nox2 does not protect against diabetic kidney disease in type 1 diabetes, despite a reduction in macrophage infiltration. The lack of renoprotection may be due to upregulation of renal Nox4...
  55. pmc Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis
    Kornélia Baghy
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    FEBS J 280:2150-64. 2013
    b>Decorin, a secreted small leucine-rich proteoglycan, acts as a tumor repressor in a variety of cancers, mainly by blocking the action of several receptor tyrosine kinases such as the receptors for hepatocyte, epidermal and insulin-like ..
  56. pmc Decorin potentiates interferon-γ activity in a model of allergic inflammation
    Carla Bocian
    Institute of Physiological Chemistry and Pathobiochemistry, Waldeyerstrasse 15, 48149 Munster, Germany
    J Biol Chem 288:12699-711. 2013
    The proteoglycan decorin modulates leukocyte recruitment during delayed-type hypersensitivity responses...
  57. pmc Intracellularly-retained decorin lacking the C-terminal ear repeat causes ER stress: a cell-based etiological mechanism for congenital stromal corneal dystrophy
    Shoujun Chen
    Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612 4799, USA
    Am J Pathol 183:247-56. 2013
    b>Decorin, a small leucine-rich proteoglycan (SLRP), is involved in the pathophysiology of human congenital stromal corneal dystrophy (CSCD). This disease is characterized by corneal opacities and vision impairment...
  58. ncbi Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues
    P Bianco
    Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892
    J Histochem Cytochem 38:1549-63. 1990
    The messenger RNAs and core proteins of the two small chondroitin/dermatan sulfate proteoglycans, biglycan and decorin, were localized in developing human bone and other tissues by both 35S-labeled RNA probes and antibodies directed ..
  59. pmc Transforming growth factor-beta 3 is required for secondary palate fusion
    G Proetzel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Genet 11:409-14. 1995
    ..No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects...
  60. pmc Interval mapping of high growth (hg), a major locus that increases weight gain in mice
    S Horvat
    Department of Animal Science, University of California, Davis 95616 8521, USA
    Genetics 139:1737-48. 1995
    ..The interval mapping and test-cross results indicate that hg is not allelic with candidate genes Igf1 or decorin (Dcn), a gene that was mapped close to hg in this study...
  61. ncbi Fine genetic mapping of the region surrounding the high growth (hg) locus in mouse chromosome 10: targeting random amplified polymorphic DNA (RAPD) markers
    S Horvat
    Department of Animal Science, University of California, Davis, California 95616 8521, USA
    Mamm Genome 7:312-4. 1996
  62. ncbi Cat3vl and Cat3vao cataract mutations on mouse chromosome 10: phenotypic characterization, linkage studies and analysis of candidate genes
    J Loster
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Mol Gen Genet 257:97-102. 1997
    ..So far, negative results have been obtained for the genes encoding the proteoglycans lumican and decorin, the nuclear orphan receptor Tr2-11 and the transcription factor Elk3...
  63. ncbi Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants
    K G Danielson
    Department of Pathology, Anatomy and Cell Biology, Room 249 Jefferson Alumni Hall, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
    Mamm Genome 10:201-3. 1999
  64. ncbi Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, Department of Surgery, Childrens Hospital Los Angeles Research Institute, University of Southern California School of Dentistry, Los Angeles 90033, USA
    Am J Physiol 277:L412-22. 1999
    ..vivo culture, we examined the capacity of a naturally occurring inhibitor of TGF-beta activity, the proteoglycan decorin, to overcome the inhibitory effects of exogenous TGF-beta...
  65. ncbi Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin
    N Matsushima
    School of Health Sciences, Sapporo Medical University, Hokkaido, Japan
    Proteins 38:210-25. 2000
    ..a family of nine small proteoglycans, forming three distinct subfamilies: class I contains biglycan/PG-I and decorin/PG-II; class II: lumican, fibromodulin, PRELP, keratocan, and osteoadherin; and class III: epiphycan/PG-Lb and ..
  66. ncbi Biglycan-like extracellular matrix genes of agnathans and teleosts
    S Shintani
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, D 72076, Tubingen, Germany
    J Mol Evol 51:363-73. 2000
    Biglycan and decorin are two members of a family of small extracellular matrix proteoglycans characterized by the presence of 10 leucine-rich repeats and one or two attachment sites for glucosaminoglycans...
  67. ncbi Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family
    S P Henry
    Graduate School of Biomedical Sciences, University of Texas, Houston, Texas, 77030, USA
    J Biol Chem 276:12212-21. 2001
    ..The deduced amino acid sequence is about 50% identical (and 70% similar) to decorin and biglycan...
  68. pmc Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint
    A M Säämänen
    Skeletal Research Programme, Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Biochem J 355:577-85. 2001
    ..was determined, and its age-related expression and distribution were characterized in knee epiphyses, with decorin studied for reference...
  69. ncbi Expression and localization of proteoglycans during limb myogenic activation
    H Olguin
    Centro de Regulación Celular y Patología, Departamento de Biología Celular y Moleculare Facultad de Ciencias Biológicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    Dev Dyn 221:106-15. 2001
    ..that the expression of myogenin was temporally and spatially coincident with the expression of syndecan-3 and decorin, two essential proteoglycans in the modulation of skeletal muscle differentiation...
  70. pmc Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathy
    Manolis Mavroidis
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 160:943-52. 2002
    ..The most substantial changes were found in genes coding the small extracellular matrix proteins osteopontin and decorin that are dramatically induced in the desmin-null myocardium...
  71. pmc Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction
    Liliana Schaefer
    Department of Internal Medicine D, Physiological Chemistry and Pathobiochemistry, and Arteriosclerosis Research, University of Munster, Munster, Germany
    Am J Pathol 160:1181-91. 2002
    b>Decorin, a small dermatan-sulfate proteoglycan, participates in extracellular matrix assembly and influences directly and indirectly cell behavior via interactions with signaling membrane receptors and transforming growth factor (TGF)-..
  72. ncbi Differential expression of glycosaminoglycans and proteoglycans in the migratory pathway of the primordial germ cells of the mouse
    Mauricio Soto-Suazo
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508 900, Brazil
    Histochem Cell Biol 118:69-78. 2002
    ..Some molecules such as chondroitin-0-sulfate, decorin, and biglycan are present only in certain phases of the migratory process of primordial germ cells...
  73. ncbi Decorin binds fibrinogen in a Zn2+-dependent interaction
    Tracey A Dugan
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas Medical Center, Houston 77030, USA
    J Biol Chem 278:13655-62. 2003
    We have previously shown that decorin, a member of the small leucine-rich proteoglycan family of extracellular matrix proteoglycans/glycoproteins is a Zn(2+) metalloprotein at physiological Zn(2+) concentrations (Yang, V. W-C...
  74. ncbi Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice
    Yuxiang Zhang
    Department of Anesthesiology, School of Medicine, Fukushima Medical University, Fukushima City, Fukushima, Japan
    Dev Dyn 226:618-26. 2003
    ..In the present study, we focused on two small leucine-rich proteoglycans, decorin and biglycan, because they assembled extracellular matrix molecules such as collagens and modulated signaling ..
  75. ncbi Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy
    Michael D Ross
    Department of Medicine, Divisions of Nephrology and Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33248-55. 2003
    ..Thus, podocan defines a new class within the SLR protein family and is a previously unrecognized component of the sclerotic glomerular lesion that develops in the course of experimental HIVAN...
  76. ncbi Inhibition of myoblast migration via decorin expression is critical for normal skeletal muscle differentiation
    Hugo C Olguin
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    Dev Biol 259:209-24. 2003
    ..limb muscle formation and showed a spatiotemporal relation between the onset of myogenesis and the expression of decorin, an important muscle extracellular matrix component and potent regulator of TGF-beta activity...
  77. ncbi Alterations in lung mechanics in decorin-deficient mice
    Anita Fust
    Meakins Christie Laboratories, Shriner s Hospital for Crippled Children, McGill University, Montreal, Quebec, Canada H2X 2P2
    Am J Physiol Lung Cell Mol Physiol 288:L159-66. 2005
    b>Decorin, a small leucine-rich proteoglycan with a widespread tissue distribution, is required for the normal fibrillogenesis of collagen in most tissues...
  78. ncbi A role for decorin in the remodeling of myocardial infarction
    Sara M Weis
    Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093, USA
    Matrix Biol 24:313-24. 2005
    Because the small leucine-rich proteoglycan decorin has been implicated in regulation of collagen fibrillogenesis leading to proper extracellular matrix assembly, we hypothesized it could play a key role in cardiac fibrosis following ..
  79. ncbi Extracellular matrix proteoglycans control the fate of bone marrow stromal cells
    Yanming Bi
    Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Biol Chem 280:30481-9. 2005
    ..Using mice deficient in two members of the small leucine-rich proteoglycans, biglycan and decorin, we uncovered a role for these two extracellular matrix proteoglycans in modulating bone formation from bone ..
  80. ncbi Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia...
  81. ncbi Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation
    Rebeca Droguett
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    Matrix Biol 25:332-41. 2006
    ..b>Decorin, biglycan and betaglycan are proteoglycans that bind TGF-beta during skeletal muscle differentiation...
  82. ncbi Matricellular hevin regulates decorin production and collagen assembly
    Millicent M Sullivan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 281:27621-32. 2006
    ..We present evidence for an altered collagen matrix and levels of the proteoglycan decorin in the normal dermis and dermal wound bed of hevin-null mice...
  83. ncbi Origin and characteristics of glycogen cells in the developing murine placenta
    P M Coan
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Dev Dyn 235:3280-94. 2006
    ..be facilitated by temporally regulated expression of matrix metalloproteinase 9 and the imprinted gene product, Decorin. Expression of the clearance receptor for type II insulin-like growth factor (IGF-II), IGF2R, in a short ..
  84. ncbi Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis
    Jinhong Zhu
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Rangos Research Center, and Department of Bioengineering, University of Pittsburgh, Pennsylvania 15213 2583, USA
    J Biol Chem 282:25852-63. 2007
    ..myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimulated fibroblast proliferation in vitro and induced its differentiation into ..
  85. ncbi Effect of PEEP on induced constriction is enhanced in decorin-deficient mice
    Francesco G Salerno
    Respiratory Unit, University of Foggia and Fondazione Salvatore Maugeri, Cassano Murge, BA Italy
    Am J Physiol Lung Cell Mol Physiol 293:L1111-7. 2007
    b>Decorin (Dcn), a small leucine-rich proteoglycan, is present in the extracellular matrix of the airways and lung tissues, contributes to lung mechanical properties, and its deposition is altered in asthma...
  86. ncbi Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice
    Adam S Raefski
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA
    J Mol Neurosci 32:111-9. 2007
    ..In silico pathway analysis of both X-linked and autosomal mis-regulated genes suggests that modulation of Wnt signaling is a critical factor in the normal growth and development of the amygdala...
  87. pmc Decorin deficiency enhances progressive nephropathy in diabetic mice
    Kevin Jon Williams
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Am J Pathol 171:1441-50. 2007
    b>Decorin, a proteoglycan that inhibits active transforming growth factor-beta, is increased in diabetic nephropathy; however, its functional significance is unclear...
  88. doi Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice
    Zishu Pan
    Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Dev Dyn 237:316-27. 2008
    ..Our study demonstrates Alkbh1 performs important functions in placental trophoblast lineage differentiation and participates in mechanisms of transcriptional regulation...
  89. pmc Genetic evidence for key roles of decorin and biglycan in dentin mineralization
    Naoto Haruyama
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Matrix Biol 28:129-36. 2009
    ..Using DSPP/biglycan (Dspp(-/-)Bgn(-/0)) and DSPP/decorin (Dspp(-/-)Dcn(-/-)) double knockout mice, here we determined that the enlarged predentin layer in Dspp(-/-) teeth ..
  90. pmc TGFbeta neutralization within cardiac allografts by decorin gene transfer attenuates chronic rejection
    Susan M Faust
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    J Immunol 183:7307-13. 2009
    ..b>Decorin, an extracellular matrix protein, inhibits both TGFbeta bioactivity and gene expression...
  91. pmc Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer
    Yanjun Gu
    Department of Pathology, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin 300060, China
    J Exp Clin Cancer Res 29:6. 2010
    ..In this study, we investigate differential gene expression, especially the expression of decorin, EGFR and cyclin D1, during mammary gland epithelial cell carcinogenesis in TA2 mice.
  92. pmc The Mohawk homeobox gene is a critical regulator of tendon differentiation
    Yoshiaki Ito
    Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    Proc Natl Acad Sci U S A 107:10538-42. 2010
    ..These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells...
  93. pmc The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis
    Wenjin Liu
    Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Biol 30:4797-807. 2010
    ..In addition to defects in tendon collagen fibrillogenesis, Mkx(-/-) mutant mice exhibited abnormal tendon sheaths. These results identify Mkx as an important regulator of tendon development...
  94. doi Decorin modulates collagen I-stimulated, but not fibronectin-stimulated, migration of C2C12 myoblasts
    K P Goetsch
    Department of Biochemistry, School of Biochemistry, Genetics and Microbiology, University of KwaZulu Natal, Scottsville, South Africa
    Matrix Biol 30:109-17. 2011
    ..b>Decorin has been identified as an anti-fibrotic agent with binding sites located on both fibronectin and collagen I...
  95. doi Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin
    M Ward
    Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
    Cell Prolif 44:343-51. 2011
    ..Pre-adipocytes were seeded on plates coated with biglycan and decorin and were allowed to differentiate...
  96. pmc Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy: C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans
    Shoujun Chen
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida
    Am J Pathol 179:2409-19. 2011
    ..It is linked to a frameshift mutation in decorin, resulting in a C-terminal truncation lacking 33 amino acids that includes the "ear" repeat, a feature specific ..
  97. ncbi Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose
    A Mogyorosi
    Renal Electrolyte and Hypertension Division, Department of Medicine, and the Penn Center for the Molecular Studies of Kidney Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol 275:F827-32. 1998
    The core protein of the proteoglycan decorin binds and neutralizes transforming growth factor-beta (TGF-beta)...
  98. ncbi Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray
    Yosuke Mizuno
    Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama 230 0045, Japan
    Biochem Biophys Res Commun 290:1499-505. 2002
    ..3 new ones--Asb4 (ankyrin repeat and SOCS box-containing protein 4), Ata3 (amino acid transport system A3), and Decorin--which were confirmed by using normal diploid embryos from the reciprocal F1 crosses of B6 and JF1 mice...
  99. ncbi Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development
    Tsuyoshi Hikake
    Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, 960 1295 Fukushima, Japan
    Anat Embryol (Berl) 206:373-80. 2003
    ..5-P4.5). Proteoglycans (versican, decorin, biglycan, glypican, syndecan-1, and syndecan-3) were expressed in the tooth germs in various patterns...
  100. ncbi Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: role of decorin in cell response to BMP-2
    Jaime Gutierrez
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 206:58-67. 2006
    ..An important and specific increase in the synthesis of secreted decorin was observed in BMP-2-treated cells, as compared to untreated myoblasts and myoblasts induced to differentiate ..
  101. ncbi Protection of adult mouse progenitor cells and human glioma cells by de novo decorin expression in an oxygen- and glucose-deprived cell culture model system
    Manoranjan Santra
    Neurology Research, Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Cereb Blood Flow Metab 26:1311-22. 2006
    ..We employed an in vitro hypoxia cell culture model system and gene transfer technology to examine the effect of the decorin gene on cell survival against oxygen and glucose deprivation (OGD)...

Research Grants2

  1. ROLE OF MGRB10 IN IGF-I INDUCED SIGNALING
    Andrea Morrione; Fiscal Year: 2002
    ....
  2. Proepithelin Signaling in Urothelial Cells
    Andrea Morrione; Fiscal Year: 2009
    ..Furthermore, the identification of novel proteins and novel mechanism(s) that regulate proepithelin action will help us in designing novel therapeutic agents to target malignant cells in bladder tumors. ..