Genomes and Genes
Gene Symbol: Dbh
Description: dopamine beta hydroxylase
Alias: dopamine beta-hydroxylase, dopamine beta-monooxygenase
Publications114 found, 100 shown here
- Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memoryS A Thomas
Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle 98195 7370, USA
Behav Neurosci 111:579-89. 1997Mice unable to synthesize norepinephrine (NE) were created by targeted disruption of the dopamine beta-hydroxylase (DBH) gene...
- Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivoDaphne M Hasbani
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 25:9428-33. 2005..These results suggest that DA does not contribute to acute MPTP toxicity in vivo...
- The homeobox gene Phox2b is essential for the development of autonomic neural crest derivativesA Pattyn
Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
Nature 399:366-70. 1999....
- Norepinephrine-deficient mice have increased susceptibility to seizure-inducing stimuliP Szot
Department of Psychiatry, University of Washington, Seattle, Washington 98195, USA
J Neurosci 19:10985-92. 1999..Seizure susceptibility was determined in the dopamine beta-hydroxylase null mutant (Dbh -/-) mouse using four different convulsant stimuli: 2,2,2-trifluroethyl ether (flurothyl), pentylenetetrazol (PTZ), ..
- Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animalsDavid Weinshenker
Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 99:13873-7. 2002..NE) signaling modulates psychostimulant responses by testing LRA in dopamine beta-hydroxylase knockout (Dbh-/-) mice that lack NE. Surprisingly, Dbh-/- animals were hypersensitive to the behavioral effects of amphetamine...
- Essential role of Gata transcription factors in sympathetic neuron developmentKonstantina Tsarovina
Max Planck Institut für Hirnforschung, Abteilung Neurochemie, Deutschordenstr 46, 60528 Frankfurt Main, Germany
Development 131:4775-86. 2004..after Mash1, Phox2b, Hand2 and Phox2a expression, but before the onset of the noradrenergic marker genes Th and Dbh, and is maintained throughout development...
- Cholinergic differentiation occurs early in mouse sympathetic neurons and requires Phox2bK Huber
Institut für Anatomie und Zellbiologie III, Interdisziplindäres Zentrum für Neurowissenschaften, Ruprecht Karls Universitat Heidelberg, Imn Neuenheimer Feld 307, 69120 Heidelberg, Germany
Gene Expr 13:133-9. 2006..Phox2b is required for development of cholinergic neurons but does not suffice to support cholinergic properties in chromaffin cells...
- Genetic or pharmacological blockade of noradrenaline synthesis enhances the neurochemical, behavioral, and neurotoxic effects of methamphetamineDavid Weinshenker
Department of Human Genetics, Emory University, Atlanta, Georgia, USA
J Neurochem 105:471-83. 2008..lacking NA (genetic or acute pharmacological blockade of the NA biosynthetic enzyme dopamine beta-hydroxylase; DBH)...
- The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neuronsKonstantina Tsarovina
Research Group Developmental Neurobiology, Max Planck Institute for Brain Research, 60528 Frankfurt M, Germany
J Neurosci 30:10833-43. 2010..Inactivation of Gata3 in embryonic DBH-expressing neurons elicits a strong reduction in neuron numbers due to apoptotic cell death and reduced ..
- Noradrenaline is essential for mouse fetal developmentS A Thomas
Department of Biochemistry, Howard Hughes Medical Institute, Seattle, Washington, USA
Nature 374:643-6. 1995..Mutant embryos had a histological phenotype similar to that of embryos deficient in tyrosine hydroxylase, suggesting that death might be due to cardiovascular failure...
- Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenalineS A Thomas
Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle 98195 7370, USA
Nature 387:94-7. 1997..The unexpected increase in basal metabolic rate is not due to hyperthyroidism, compensation by the widely expressed uncoupling protein UCP2, or shivering...
- Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylaseS A Thomas
Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, USA
J Neurochem 70:2468-76. 1998Mice with a targeted disruption of the dopamine beta-hydroxylase (DBH) gene are unable to synthesize norepinephrine (NE) and epinephrine...
- Contribution of Hox genes to the diversity of the hindbrain sensory systemGary O Gaufo
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Development 131:1259-66. 2004..More generally, these findings contribute to our understanding of how Hox genes specifically control cellular diversity in the developing organism..
- c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant miceK Burau
Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
Eur J Neurosci 20:353-62. 2004..Our data suggest that c-ret signalling is necessary for the maturation of cholinergic sympathetic neurons but dispensable for de novo induction of ChAT and VAChT expression...
- Locus coeruleus neurons originate in alar rhombomere 1 and migrate into the basal plate: Studies in chick and mouse embryosPilar Aroca
Department of Human Anatomy and Psychobiology, Medical School, University of Murcia, Spain
J Comp Neurol 496:802-18. 2006..studied the topography of the developing LoC in the hindbrain, using as markers the key noradrenergic marker gene Dbh and the transcription factors Phox2a and Phox2b (upstream of Dbh)...
- Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosisRosanna Parlato
Department of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
Development 134:1663-70. 2007..Thus, our analysis indicates that the activity of cell-autonomous pro-survival signalling is operative in developing sympathetic neurons in the absence of CREB...
- Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous systemYuka Morikawa
Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, USA
Dev Biol 307:114-26. 2007..the levels of the norepinephrine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was examined...
- Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxietyJesse R Schank
Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
Biol Psychiatry 63:1007-12. 2008..While the mechanisms underlying cocaine's rewarding effects have been studied extensively, less attention has been paid to the unpleasant behavioral states induced by cocaine, such as anxiety...
- Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiationEva Coppola
Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
Development 137:4211-20. 2010....
- The full expression of fasting-induced torpor requires beta 3-adrenergic receptor signalingSteven J Swoap
Department of Biology, Williams College, Williamstown, Massachusetts 01267, USA
J Neurosci 26:241-5. 2006..the torpor adaptation to fasting by telemetrically monitoring the Tb of dopamine beta-hydroxylase knock-out (Dbh-/-) mice, which lack the ability to produce the SNS transmitters, norepinephrine (NE), and epinephrine...
- Stage-specific expression of alkaline phosphatase during neural development in the mouseS Narisawa
La Jolla Cancer Research Foundation, Cancer Research Center, California 92037
Dev Dyn 201:227-35. 1994..We conclude that AP is a useful marker of a subpopulation of neuroectodermal cells present in the neural tube as early as E8.5, at which stages there are no other AP positive intraembryonic cells except PGCs...
- Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous systemN A Compagnone
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143, USA
Endocrinology 136:5212-23. 1995....
- Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activityY Shi
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York 10032, USA
Genes Dev 9:2583-97. 1995..We suggest that the Abi-1 protein may serve as a regulator of Abl function in transformation or in signal transduction...
- Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndromeH Chen
Department of Biochemistry and Molecular Biology, U T M D Anderson Cancer Center, Houston, USA
Nat Genet 19:51-5. 1998..Our results demonstrate an essential function for Lmx1b in mouse limb and kidney development and suggest that NPS might result from mutations in the human LMX1B gene...
- Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient miceM S Szczypka
Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle 98195, USA
Neuron 22:167-78. 1999..TH immunoreactivity and DA were detected in the ventral striatum and adjacent posterior regions of rescued mice, suggesting that these regions mediate a critical DA-dependent aspect of feeding behavior...
- Dopamine beta-hydroxylase deficiency impairs cellular immunityR C Alaniz
Department of Immunology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 96:2274-8. 1999..We addressed this question genetically by using mice that lack dopamine beta-hydroxylase (dbh-/- mice). dbh-/- mice cannot produce norepinephrine or epinephrine, but produce dopamine instead...
- GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglionJ Nishino
Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
Neuron 23:725-36. 1999..These observations suggest that GFR alpha3-mediated signaling is required both for the rostral migration of SCG precursors and for the survival of mature SCG neurons...
- Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanismCarlos A Paladini
Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
Proc Natl Acad Sci U S A 100:2866-71. 2003..These data suggest that endogenously released dopamine plays a critical role in the afferent control of dopamine neuron bursting activity and that this control is exerted via a network feedback mechanism...
- Peptides that regulate food intake: norepinephrine is not required for reduction of feeding induced by cholecystokininC Matson Cannon
Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195 7370, USA
Am J Physiol Regul Integr Comp Physiol 284:R1384-8. 2003..NE) is necessary for satiety induced by peripheral CCK-8 by using mice lacking dopamine beta-hydroxylase (Dbh(-/-)), the enzyme responsible for synthesizing NE and epinephrine from dopamine...
- The role of dopamine in learning, memory, and performance of a water escape taskVictor H Denenberg
Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195 7370, USA
Behav Brain Res 148:73-8. 2004....
- Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypyElena H Chartoff
Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Brain Res 1022:71-80. 2004....
- Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of gliaFabien D'Autréaux
Department of Pathology and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
Development 134:2237-49. 2007..We suggest that enteric neuronal development occurs in stages and that Hand2 expression is required for terminal differentiation but not for precursors to enter the neuronal lineage...
- Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineageHendrik Wildner
Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
Development 135:473-81. 2008..of sympatho-adrenal precursors, as assessed by the expression of neuronal subtype-specific genes such as Th and Dbh, is delayed in a pronounced manner, which is accompanied by a reduced proliferation...
- Regulation of gene expression of catecholamine biosynthetic enzymes in dopamine-beta-hydroxylase- and CRH-knockout mice exposed to stressRichard Kvetnansky
Institute of Experimental Endocrinology, Centre of Excellence CENDO, Slovak Academy of Sciences, Bratislava, Slovak Republic
Ann N Y Acad Sci 1148:257-68. 2008Norepinephrine-deficient mice harbor a disruption of the gene for dopamine-beta-hydroxylase (DBH-KO). Corticotropin-releasing hormone knockout mice (CRH-KO) have markedly reduced HPA activity...
- Increased basement membrane thickness, pericyte ghosts, and loss of retinal thickness and cells in dopamine beta hydroxylase knockout miceJena J Steinle
Departments of Ophthalmology and Anatomy and Neurobiology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Exp Eye Res 88:1014-9. 2009..To test this, retinas from non-diabetic dopamine beta hydroxylase (Dbh, Dbh(-/-)) knockout mice and their littermate controls were assessed for diabetic-like capillary ..
- Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrainJohn Jacob
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 136:2477-85. 2009..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
- Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neuronsHadas Tilleman
Zlotowski Center for Neuroscience, Department of Morphology, Division of Basic Sciences, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
Mol Cell Neurosci 45:1-11. 2010..In addition, we conclude that the position of the mid-hindbrain organizer determines the size of the LC and propose that Bmp5/7 play an important role in mediating this organizer function...
- The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrievalLei Zhang
Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
J Neurosci 33:5006-16. 2013....
- Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crestJoshua W Vincentz
Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Division of Pediatrics Cardiology, Departments of Anatomy, Indiana University Medical School, Indianapolis, Indiana, United States of America
PLoS Genet 9:e1003405. 2013..These data demonstrate that Twist1 functions in post-migratory neural crest cells to repress pro-neural factors and thereby regulate cell fate determination between ectodermal and mesodermal lineages...
- Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal deathNathan J Vandusen
Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Departments of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, IN 46202 5225, USA
Dev Biol 388:149-58. 2014..In both cases, Hand2 loss-of-function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh), a gene encoding a crucial catecholaminergic biosynthetic enzyme...
- Nicotinic receptor Alpha7 expression during mouse adrenal gland developmentLorise C Gahring
Salt Lake City VA Geriatric Research, Education and Clinical Center, Salt Lake City, Utah, United States of America Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, United States of America
PLoS ONE 9:e103861. 2014..by their progressive increase in the co-expression of tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) that is complete by E18.5...
- The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neuronsC Fode
IGBMC, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
Neuron 20:483-94. 1998..Interestingly, the homeobox gene Phox2a is activated independently of ngn2 in epibranchial placodes, suggesting that neuronal fate and neuronal subtype identity may be specified independently in cranial sensory ganglia...
- Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous systemK C Lim
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA
Nat Genet 25:209-12. 2000..find here that null mutation of Gata3 leads to reduced accumulation of Th (encoding tyrosine hydroxylase, Th) and Dbh (dopamine beta-hydroxylase, Dbh) mRNA, whereas several other SNS genes are unaffected...
- Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesiaSiobhan Robinson
Neurobiology and Behavior Program, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 101:13329-34. 2004..These data suggest that restoration of endogenous dopamine signaling activates hypersensitive long-loop feedback pathways that serve to limit dopamine release and underscore the importance of recording from awake animals...
- Pontine norepinephrine defects in Mecp2-null mice involve deficient expression of dopamine beta-hydroxylase but not a loss of catecholaminergic neuronsXiaoli Zhang
Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30303, USA
Biochem Biophys Res Commun 394:285-90. 2010..deficiency in tyrosine hydroxylase (TH) has been demonstrated, it is possible that dopamine beta-hydroxylase (DBH), the critical enzyme converting dopamine to NE, is also affected...
- A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesisJoshua W Vincentz
Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Division of Pediatric Cardiology, Department of Anatomy, Indiana Medical School, Indianapolis, Indiana 46202 5225, USA
J Neurosci 32:2110-20. 2012..Finally, we demonstrate that Hand1 is dispensable for normal tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) expression in sympathetic neurons, even when Hand2 gene dosage is concurrently reduced by half...
- Developmental expression of orphan G protein-coupled receptor 50 in the mouse brainEllen Grünewald
Medical Genetics Section, University of Edinburgh, Institute of Genetics and Molecular Medicine, Molecular Medicine Centre, Crewe Road, Edinburgh EH2 4XU, United Kingdom
ACS Chem Neurosci 3:459-72. 2012..With this study, we identify a link between GPR50 and neurotransmitter signaling and strengthen a likely role in stress response and energy homeostasis...
- Developmental origins of central norepinephrine neuron diversitySabrina D Robertson
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Nat Neurosci 16:1016-23. 2013....
- Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3Y Qian
The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 15:2533-45. 2001....
- A mutation in the ATP7B copper transporter causes reduced dopamine beta-hydroxylase and norepinephrine in mouse adrenalVincent Gerbasi
Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Neurochem Res 28:867-73. 2003..One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepinephrine and epinephrine, neurohormones in endocrine and nervous tissue...
- Leptin regulation of bone resorption by the sympathetic nervous system and CARTFlorent Elefteriou
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 434:514-20. 2005..Our study establishes that leptin-regulated neural pathways control both aspects of bone remodelling, and demonstrates that integrity of sympathetic signalling is necessary for the increase in bone resorption caused by gonadal failure...
- In vivo role for CREB signaling in the noradrenergic differentiation of sympathetic neuronsRoland Rüdiger
RG Developmental Neurobiology, Department Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstr 46, D 60528 Frankfurt M, Germany
Mol Cell Neurosci 42:142-51. 2009..development proceeds normally in CREB-deficient mouse embryos, a decrease in noradrenergic differentiation (TH, DBH) was observed in chick sympathetic ganglia in response to ACREB, a dominant-negative CREB variant which interferes ..
- Redundant catecholamine signaling consolidates fear memory via phospholipase CMing Ouyang
Department of Pharmacology and Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
J Neurosci 32:1932-41. 2012..The results support recent evidence indicating that blocking β-adrenergic receptors alone shortly after trauma may not be sufficient to prevent PTSD...
- Adrenergic deficiency leads to impaired electrical conduction and increased arrhythmic potential in the embryonic mouse heartCandice Baker
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd, Orlando, FL 32827, USA
Biochem Biophys Res Commun 423:536-41. 2012..model where adrenergic hormone production was blocked due to targeted disruption of the dopamine β-hydroxylase (Dbh) gene...
- Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolismKingsley Osuala
Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida 32827, USA
Physiol Genomics 44:934-47. 2012..To perform this study, we used a mouse model with targeted disruption of the Dopamine β-hydroxylase (Dbh) gene, whose product is responsible for enzymatic conversion of dopamine into norepinephrine...
- Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expressionMayumi Nagashimada
Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan
J Clin Invest 122:3145-58. 2012..mutation of PHOX2B reduced transactivation of wild-type PHOX2B on its known target, dopamine β-hydroxylase (DBH), in a dominant-negative fashion...
- Severe stress switches CRF action in the nucleus accumbens from appetitive to aversiveJulia C Lemos
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA
Nature 490:402-6. 2012..Thus, the current findings offer a biological substrate for the switch in affect which is central to stress-induced depressive disorders...
- The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversificationAlessandro Furlan
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden
EMBO J 32:1613-25. 2013....
- Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78, Pbx3, and Notch1 genes in the region of mouse chromosome 2 homologous to human chromosome 9qA Pilz
Department of Genetics and Biometry, University College London, United Kingdom
Genomics 21:104-9. 1994..The consensus gene order deduced by combining data from both crosses is D2Mit1-(Dbh,Notch1)-(Col5a1,Rxra)-Spna2-Ab l-(Ak1,Fpgs)- (Grp78,Pbx3)-(Epb7.2,Hc,Gsn)-Acra...
- Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complexM Kasahara
Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
Proc Natl Acad Sci U S A 93:9096-101. 1996..3 and 9q33-q34). These observations have implications in understanding the genomic organization of the present-day MHC and offer insights into the origin of the MHC...
- The isolation and mapping of PCR markers specific to mouse Chromosome 2S Malas
Department of Genetics and Biometry, University College London, UK
Mamm Genome 7:145-8. 1996
- The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous systemM C Tiveron
Institut de Biologie du Developpement de Marseille, Centre National dela Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de la Mediterranée, Marseille, France
J Neurosci 16:7649-60. 1996..e., that of the medullary control reflexes of autonomic functions. This suggests that Phox2 could be involved in the establishment of these circuits...
- Norepinephrine facilitates the development of the murine sweat response but is not essentialA T Tafari
Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, Washington 98195 7370, USA
J Neurosci 17:4275-81. 1997..We tested this hypothesis in vivo using dopamine beta-hydroxylase-deficient mice (DBH -/-), which are unable to synthesize NE and epinephrine, and tyrosine hydroxylase-deficient mice (TH -/-), which ..
- Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesisA Pattyn
Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, France
Development 124:4065-75. 1997..This suggests that Phox2b links early patterning events to the differentiation of defined neuronal populations in the hindbrain...
- Impaired maternal behavior in mice lacking norepinephrine and epinephrineS A Thomas
Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle 98195, USA
Cell 91:583-92. 1997..NE) and epinephrine in behavior were investigated by targeted disruption of the dopamine beta-hydroxylase (Dbh) gene, thereby eliminating these compounds in vivo...
- Dopamine-stimulated sexual behavior is testosterone dependent in miceM S Szczypka
Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle 98195 7370, USA
Behav Neurosci 112:1229-35. 1998..In addition, replacement of testosterone to castrated males showed that the testosterone-responsive pathways of DA-/- males were more sensitive to testosterone than wild-type mice...
- Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrainM Davenne
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, Strasbourg
Neuron 22:677-91. 1999....
- Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoformY Saga
Banyu Tsukuba Research Institute Merck Tsukuba, Ibaraki, 300 33 Japan
Genes Cells 4:219-28. 1999..In contrast to the widespread expression of RXRalpha and RXRbeta, the expression of RXRgamma is restricted to particular tissues in which RXRgamma1 is the major isoform expressed in the mouse corpus striatum...
- Feeding behavior in dopamine-deficient miceM S Szczypka
Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, WA 98195 7370, USA
Proc Natl Acad Sci U S A 96:12138-43. 1999..Therefore, DA-/- mice can execute behaviors necessary to seek and ingest food, but they do not eat enough to survive...
- Ethanol-associated behaviors of mice lacking norepinephrineD Weinshenker
Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
J Neurosci 20:3157-64. 2000..to determine the effect of NE depletion on ethanol-mediated behaviors by using dopamine beta-hydroxylase knockout (Dbh -/-) mice that specifically lack the ability to synthesize NE...
- Dopamine is required for hyperphagia in Lep(ob/ob) miceM S Szczypka
Howard Hughes Medical Institute and Department of Biochemistry, Box 357370, University of Washington, Seattle, Washington, USA
Nat Genet 25:102-4. 2000..Dopamine-deficient mice (Dbh(Th/+), Th-/-; hereafter DD mice) cannot synthesize dopamine in dopaminergic neurons...
- Role of the target in the pathfinding of facial visceral motor axonsJ Jacob
MRC Centre for Developmental Neurobiology, King s College, Guy s Campus, 4th floor New Hunt s House, London, SE1 9RT, United Kingdom
Mol Cell Neurosci 16:14-26. 2000..Moreover, the absence of correct facial visceral motor pathways was concomitant with defects in the pathfinding of rostrally-projecting sympathetic axons...
- Dopamine production in the caudate putamen restores feeding in dopamine-deficient miceM S Szczypka
Howard Hughes Medical Institute and, Department of Biochemistry, Box 357370, University of Washington, Seattle, WA 98195, USA
Neuron 30:819-28. 2001..These data suggest that a fundamental difference exists between feeding for sustenance and the ability to prefer rewarding substances...
- Use of dopamine-beta-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugsJ F Cryan
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
J Pharmacol Exp Ther 298:651-7. 2001..that are unable to synthesize NE and epinephrine due to targeted disruption of the dopamine-beta-hydroxylase gene (Dbh)...
- Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophyA Rapacciuolo
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Am Coll Cardiol 38:876-82. 2001..We sought to define the role of norepinephrine and epinephrine in the development of cardiac hypertrophy and to determine whether the absence of circulating catecholamines alters the activation of downstream myocardial signaling pathways...
- Genetic comparison of seizure control by norepinephrine and neuropeptide YD Weinshenker
Departments of Howard Hughes Medical Institute, Biochemistry, Clinical Center, University of Washington, Seattle, Washington 98195, USA
J Neurosci 21:7764-9. 2001..NPY knock-out (NPY KO) and dopamine beta-hydroxylase knock-out (DBH KO) mice that lack NE are susceptible to seizures, and agonists of NE and NPY receptors protect against seizures...
- Role of catecholamine signaling in brain and nervous system functions: new insights from mouse molecular genetic studyK Kobayashi
Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Japan
J Investig Dermatol Symp Proc 6:115-21. 2001....
- Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stressGiovanni Esposito
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Circulation 105:85-92. 2002..Epidemiological data, however, have shown that cardiac hypertrophy is associated with increased mortality, thus casting doubt on the validity of this hypothesis...
- Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient miceDouglas S Kim
Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7275, USA
Proc Natl Acad Sci U S A 100:1346-51. 2003..This study of a genetic model of dopamine depletion provides evidence that A(2A) receptor antagonists could ameliorate the hypokinetic symptoms of advanced Parkinson's disease patients without inducing excessive motor activity...
- FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signalsRas Trokovic
Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland
EMBO J 22:1811-23. 2003..In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border...
- Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neuronsPontus C Holm
Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm S 171 77, Sweden
Development 130:3535-45. 2003..In summary, our findings suggest that, unlike NT3 and GDNF, TrkB ligands are required and sufficient to promote the development of central noradrenergic neurons...
- Norepinephrine and epinephrine-deficient mice are hyperinsulinemic and have lower blood glucoseLinda Ste Marie
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Endocrinology 144:4427-32. 2003..The absence of NE and Epi in dopamine beta-hydroxylase-null (Dbh-/-) mice results in chronically low blood glucose levels, an impaired glucagon response to hypoglycemia, and ..
- Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stressSteven J Swoap
Department of Biology, Williams College, Williamstown, MA 01267, USA
Am J Physiol Regul Integr Comp Physiol 286:R108-13. 2004We used mice deficient in dopamine beta-hydroxylase [Dbh(-/-)] and their littermate controls [Dbh(+/-)] to examine the role of epinephrine (Epi) and norepinephrine (NE) in the maintenance of cardiovascular parameters during 7 days of ..
- MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birthBruno Blanchi
Centre d immunologie de Marseille Luminy, CNRS INSERM Université Mediterrané, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
Nat Neurosci 6:1091-100. 2003..Our results show an essential role of MafB in central respiratory control, possibly involving the specification of rhythmogenic preBötC neurons...
- Reward without dopamineClaire Matson Cannon
Department of Biochemistry and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195 7370, USA
J Neurosci 23:10827-31. 2003..Thus, DA is not required for mice to learn to consume sweet solutions preferentially. We conclude that DA is not required to find the sweet tastes of sucrose or saccharin rewarding...
- Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitorsJohn F Cryan
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:8186-91. 2004..to synthesize norepinephrine (NE) and epinephrine due to targeted disruption of the dopamine beta-hydroxylase gene, Dbh, were used to critically test roles for NE in mediating acute behavioral changes elicited by different classes of ..
- Altered sleep latency and arousal regulation in mice lacking norepinephrineMelissa S Hunsley
Howard Hughes Medical Institute and Department of Biochemistry, Box 357370, University of Washington, Seattle, WA 98195 7370, USA
Pharmacol Biochem Behav 78:765-73. 2004..The results presented here suggest that NE promotes wakefulness during transitions between sleep and wake under conditions involving mild stress and SD, but not under baseline circumstances...
- Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitisZhiping Li
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Hepatology 40:434-41. 2004..In conclusion, low NE activity increases hepatic NKT cell apoptosis and depletes liver NKT cells, promoting proinflammatory polarization of hepatic cytokine production that sensitizes the liver to LPS toxicity...
- Vlgr1 knockout mice show audiogenic seizure susceptibilityHideshi Yagi
Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Japan
J Neurochem 92:191-202. 2005..Our monogenic mice, which have a unique genetic background, serve as a useful tool for further studies on seizures...
- Adrenergic catecholamine trophic activity contributes to flow-mediated arterial remodelingCauveh Erami
Department of Cell and Molecular Physiology, 474 MSRB, Univ of North Carolina, Chapel Hill, NC 27599 7545, USA
Am J Physiol Heart Circ Physiol 289:H744-53. 2005..wild-type mice or mice deficient in norepinephrine and epinephrine synthesis [dopamine beta-hydroxylase knockout (DBH-KO)], all distal branches of the left carotid artery (LC) except the thyroid artery were ligated to reduce flow in ..
- Genetic reduction of noradrenergic function alters social memory and reduces aggression in miceMelissa D Marino
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Behav Brain Res 161:197-203. 2005..We tested dopamine beta-hydroxylase knockout (Dbh -/-) mice that lack NA in various social behavior paradigms...
- Norepinephrine- and epinephrine-deficient mice gain weight normally on a high-fat dietLinda Ste Marie
Department of Biochemistry, Howard Hughes Medical Institute, Box 357370, University of Washington, Seattle, WA 98195, USA
Obes Res 13:1518-22. 2005..one would predict that mice unable to make NE/Epi because of inactivation of the dopamine beta-hydroxylase gene (Dbh-null mice) would have a propensity to become obese...
- Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiationEva Coppola
TIGEM Telethon Institute of Genetics and Medicine, Napoli, Italy, and MRC Centre for Developmental Neurobiology, King s College Guy s Campus, London, UK
EMBO J 24:4392-403. 2005..Therefore, our analysis strongly indicates that biochemical differences between the proteins rather than temporal regulation of their expression account for the specific function of each paralogue...
- Morphine reward in dopamine-deficient miceThomas S Hnasko
Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195, USA
Nature 438:854-7. 2005....
- Delays in neuronal differentiation in Mash1/Ascl1 mutantsAlexandre Pattyn
CNRS UMR 8542, Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
Dev Biol 295:67-75. 2006..Finally, we provide evidence that the acceleration imposed by Mash1, regardless of the production of post-mitotic cells, affects differentiation itself, both generic and type-specific...
- Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesiaThomas S Hnasko
Graduate Program in Neurobiology and Behavior, Department of Biochemistry, and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 103:8858-63. 2006..This approach offers numerous advantages compared with previous models aimed at examining dopamine signaling in discrete dopaminergic circuits...
- Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndromeTom Van de Putte
Laboratory of Molecular Biology Celgen, KULeuven, Herestraat 49, B 3000 Leuven, Belgium
Hum Mol Genet 16:1423-36. 2007....
- Norepinephrine loss produces more profound motor deficits than MPTP treatment in miceK S Rommelfanger
Department of Human Genetics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:13804-9. 2007..a battery of coordinated movement tests and examining motor deficits in dopamine beta-hydroxylase knockout (Dbh-/-) mice that lack NE altogether...
- Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signalingDermot F Reilly
Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
Arterioscler Thromb Vasc Biol 28:121-6. 2008..Molecular clocks have been described in the heart and the vasculature; however it is largely unknown how the suprachiasmatic nucleus (SCN) entrains these peripheral oscillators...
- Norepinephrine controls both torpor initiation and emergence via distinct mechanisms in the mouseSteven J Swoap
Department of Biology, Williams College, Williamstown, Massachusetts, United States of America
PLoS ONE 3:e4038. 2008..We previously showed that dopamine beta-hydroxylase knockout (Dbh -/-) mice, which lack norepinephrine (NE), do not reduce circulating leptin upon fasting nor do they enter torpor...
- Dopamine is necessary for cue-dependent fear conditioningJonathan P Fadok
Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195, USA
J Neurosci 29:11089-97. 2009..These findings indicate that DA acting on multiple receptor subtypes within multiple target regions facilitates the stabilization of fear memory...
- TRH in mediating the bradycardia of caloric restrictionSteven Swoap; Fiscal Year: 2005..The mice to be used in this proposal will be lacking an intact sympathetic nervous system (Dbh-/-), lacking parasympathetic nervous system to the heart (M2R-/-), hypothyroid, and lacking the neurotransmitter, ..
- Disulfiram, DBH, and cocaine-induced anxietyDavid Weinshenker; Fiscal Year: 2005..The enzyme dopamine beta-hydroxylase (DBH) converts DA to NE in noradrenegic cells, thus controlling the abundance of both NE and DA in the brain...
- Role of dopamine D1 receptors in morphine withdrawalElena Chartoff; Fiscal Year: 2006..This work may lead to new pharmacotherapies that can alleviate aversive and dysphoric states associated with opiate withdrawal and perhaps reduce relapse to drug taking. ..
- Modeling genetically controlled DBH activity in miceDavid Weinshenker; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, adrenergic neurons, and adrenal chromaffin cells...
- A Rodent Model of Epilepsy and Depression Co-morbidityDavid Weinshenker; Fiscal Year: 2007..Completion of these aims will develop animal models with which to study epilepsy and depression comorbidity and lay the groundwork for identification of genes that contribute to both diseases. ..
- Cellular Mechanisms in Cocaine Self-AdministrationCARLOS PALADINI; Fiscal Year: 2007..Recordings from yoked-controls will also be used. Intracranial microinjections will also be used to determine whether the mGluR response can control cocaine self-administration. ..
- Consequences of repeated kappa receptor activation on brain stimulation rewardElena Chartoff; Fiscal Year: 2006..abstract_text> ..
- Mechanism of Disulfiram-Induced Cocaine AbstinenceDavid Weinshenker; Fiscal Year: 2009..The enzyme dopamine (3-hydroxylase(DBH) converts DA to NE in noradrenegic cells, thus controlling the abundanceof both NE and DA in the brain...