Dand5

Summary

Gene Symbol: Dand5
Description: DAN domain family member 5, BMP antagonist
Alias: Cerl-2, Cerr2, Dte, GREM3, coco, DAN domain family member 5, DAN domain family, member 5, cerberus-like protein 2, dante
Species: mouse

Top Publications

  1. ncbi A mouse cerberus/Dan-related gene family
    J J Pearce
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, M5G 1X5, Ontario, Canada
    Dev Biol 209:98-110. 1999
  2. ncbi Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo
    Ana Teresa Tavares
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    Development 134:2051-60. 2007
  3. pmc The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node
    José Manuel Inácio
    Regenerative Medicine Program, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal
    PLoS ONE 8:e60406. 2013
  4. doi Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA
    Tetsuya Nakamura
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Suita 565 0871, Japan
    Nat Commun 3:1322. 2012
  5. doi Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia
    Christine E Larkins
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
    Dev Biol 367:15-24. 2012
  6. doi Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos
    Shinya Oki
    Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Development 136:3917-25. 2009
  7. pmc Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos
    Aiko Kawasumi
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 353:321-30. 2011
  8. pmc The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
    Sara Marques
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    Genes Dev 18:2342-7. 2004
  9. pmc Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination
    Daniel T Grimes
    MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
    PLoS Genet 12:e1006070. 2016
  10. pmc Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells
    Maja C Funk
    University Medical Centre, Renal Department, Centre for Clinical Research, Freiburg, Germany Spemann Graduate School of Biology and Medicine, Freiburg, Germany
    EMBO J 34:1078-89. 2015

Scientific Experts

  • Tetsuya Nakamura
  • Robert A White
  • Ana Teresa Tavares
  • Hiroshi Hamada
  • Jose Antonio Belo
  • Sara Marques
  • Daniel T Grimes
  • Kyosuke Shinohara
  • Satoko Yoshiba
  • Hidetaka Shiratori
  • Keiko Kitajima
  • Chikara Meno
  • Aiko Kawasumi
  • Leonie Alten
  • Shinya Oki
  • Milena B Furtado
  • Anja Beckers
  • Maja C Funk
  • Kristen S Barratt
  • Kimberly Fuller
  • DANIEL CONCEPCION
  • Ana Carolina Araújo
  • Dominic P Norris
  • José Manuel Inácio
  • Yanick Botilde
  • Kenjiro Katsu
  • Christine E Larkins
  • Manuel Viotti
  • Ranajeet S Saund
  • Yukio Saijoh
  • Kylie Lopes Floro
  • Sarah Field
  • Doris Kinzel
  • Sally L Dunwoodie
  • Richard P Harvey
  • Achim Gossler
  • Jost I Preis
  • Duncan B Sparrow
  • Akihiko Ishimura
  • Amit Kumar
  • Kenryo Furushima
  • Stephen A Murray
  • Orna Avsian-Kretchmer
  • Shinohara Kyosuke
  • Jennifer L Keynton
  • Surya M Nauli
  • Saloni H Patel
  • Rohanah Hussain
  • Debbie J Williams
  • Maria T Buenavista
  • Renato Mastrangeli
  • Jennifer Vibert
  • Xingjian Jin
  • Agata N Bera
  • Tabea Menchen
  • Heymut Omran
  • Sebastian J Arnold
  • Kerstin Thriene
  • Georg Kuales
  • Jörn Dengjel
  • Marcus Frank
  • Soeren S Lienkamp
  • Olivier Mauti
  • Julie Gordon
  • Takeshi Fujiwara
  • Virginia E Papaioannou
  • Hannah C Glanville-Jones
  • Ruth M Arkell
  • Joyce T O'Connell
  • JONATHAN EGGENSCHWILER
  • Yasuyuki Ohkawa
  • Hiromi Nishimura
  • Tomoyuki Sumi
  • Toshiaki Hasegawa
  • Junichi Nakai
  • Ivana Y Kuo
  • Karin Schuster-Gossler
  • Stephanie Groos
  • Lei Niu
  • Barbara E Ehrlich
  • Tamara Caspary
  • Song Hai Shi
  • Masami Kanai-Azuma
  • Norifumi Tatsumi
  • Mary T Lucero
  • Alyssa Bushey Long
  • Bernd Dworniczak
  • Anna Katerina Hadjantonakis
  • Daisuke Tokumori
  • Bärbel Ulmer

Detail Information

Publications35

  1. ncbi A mouse cerberus/Dan-related gene family
    J J Pearce
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, M5G 1X5, Ontario, Canada
    Dev Biol 209:98-110. 1999
    ..In the mouse, there are at least five family members: Cer1, Drm, PRDC, Dan, and Dte. These genes are expressed in patterns that suggest that they may play important roles in patterning the developing ..
  2. ncbi Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo
    Ana Teresa Tavares
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    Development 134:2051-60. 2007
    ..We propose that cCer and mouse Cerl-2 have evolved distinct regulatory mechanisms but retained a conserved function in left-right development, which is to restrict Nodal activity to the left side of the embryo...
  3. pmc The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node
    José Manuel Inácio
    Regenerative Medicine Program, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal
    PLoS ONE 8:e60406. 2013
    ..Simultaneous genetic removal of both Nodal node inhibitors, Cerl2 and Lefty1, sustains even longer and bilateral this LPM expression...
  4. doi Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA
    Tetsuya Nakamura
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Suita 565 0871, Japan
    Nat Commun 3:1322. 2012
    ..Mathematical modelling and experimental data suggest that these feedback loops behave as a bistable switch that can amplify in a noise-resistant manner a small bias conferred by fluid flow...
  5. doi Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia
    Christine E Larkins
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
    Dev Biol 367:15-24. 2012
    ..Symmetric Nodal and Cerl2 in the node could result from defects in either the generation and/ or the detection of Nodal flow, which would account for the subsequent defects in the LPM and organ positioning...
  6. doi Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos
    Shinya Oki
    Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Development 136:3917-25. 2009
    ..In the node of wild-type embryos, the expression of Nodal and Cerl2 (Dand5), which encodes an inhibitor of Nodal, is asymmetric, with the level of Nodal expression being higher on the left ..
  7. pmc Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos
    Aiko Kawasumi
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 353:321-30. 2011
    ..Our results suggest that LPM is the direct target of Nodal secreted by the perinodal cells, and that an L>R distribution of active Nodal in the node is translated into the asymmetry in LPM...
  8. pmc The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
    Sara Marques
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    Genes Dev 18:2342-7. 2004
    ..Our results demonstrate that Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side...
  9. pmc Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination
    Daniel T Grimes
    MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
    PLoS Genet 12:e1006070. 2016
    ..Our demonstration that PKD1L1 protein can mediate a response to flow coheres with a mechanosensation model of flow sensation in which the force of fluid flow drives asymmetric gene expression in the embryo. ..
  10. pmc Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells
    Maja C Funk
    University Medical Centre, Renal Department, Centre for Clinical Research, Freiburg, Germany Spemann Graduate School of Biology and Medicine, Freiburg, Germany
    EMBO J 34:1078-89. 2015
    ..Collectively, this study implicates CCNO as first known regulator of deuterosome formation and function for the amplification of centrioles in MCCs. ..
  11. pmc Targeted inactivation of Cerberus like-2 leads to left ventricular cardiac hyperplasia and systolic dysfunction in the mouse
    Ana Carolina Araújo
    Laboratory of Embryology and Genetic Manipulation, Regenerative Medicine Program, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Campus de Gambelas, Faro, Portugal IBB Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e Estrutural, Universidade do Algarve, Campus de Gambelas, Faro, Portugal PhD Program in Biomedical Sciences, Universidade do Algarve, Campus de Gambelas, Faro, Portugal
    PLoS ONE 9:e102716. 2014
    ....
  12. pmc Nature and extent of left/right axis defects in T(Wis) /T(Wis) mutant mouse embryos
    DANIEL CONCEPCION
    Department of Genetics and Development, Columbia University Medical Center, New York, New York
    Dev Dyn 243:1046-53. 2014
    ..Previous work has implicated node morphology in this effect. We use the T(Wis) allele of Brachyury to investigate the molecular and morphological effects of the T locus on axis determination in the mouse...
  13. doi Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway
    Kimberly Fuller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States
    Dev Biol 391:182-95. 2014
    ..Collectively, these data suggest that Rab23 is an essential component of the mechanism that transmits asymmetric patterning information from the node to the LPM. ..
  14. doi The Zic2 gene directs the formation and function of node cilia to control cardiac situs
    Kristen S Barratt
    Early Mammalian Development Laboratory, Research School of Biology, Evolution, Ecology and Genetics, The Australian National University, Canberra, ACT 0200, Australia
    Genesis 52:626-35. 2014
    ..Zic2 appears to be a component of the gene regulatory network that drives ciliation of node cells during gastrulation...
  15. doi Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo
    Yanick Botilde
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 381:203-12. 2013
    ..Our results suggest that Cluap1 contributes to ciliogenesis by regulating the intraflagellar transport (IFT) cycle at the base and tip of the cilium...
  16. doi Wnt signaling regulates left-right axis formation in the node of mouse embryos
    Keiko Kitajima
    Department of Developmental Biology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Dev Biol 380:222-32. 2013
    ..Our results suggest that Wnt signaling regulates the asymmetry of Cerl2 expression, which likely generates a left-right difference in Nodal activity at the node for further amplification in lateral plate mesoderm...
  17. pmc The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning
    Anja Beckers
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 104:15765-70. 2007
    ..Our results establish Noto as an essential regulator of node morphogenesis and ciliogenesis in the posterior notochord, and suggest Noto acts upstream of Foxj1 and Rfx3...
  18. doi BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo
    Kenjiro Katsu
    Division of Pattern Formation, Department of Organogenesis, Institute of Molecular Embryology and Genetics, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Dev Biol 363:15-26. 2012
    ..Our data indicate that Dan plays an essential role in the establishment of the L-R axis by inhibiting BMP signaling around the node...
  19. doi Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1
    Leonie Alten
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Development 139:1276-84. 2012
    ..Thus, the function of Foxj1 in vertebrate organs of asymmetry is conserved, and Noto regulates node morphogenesis and the posterior localization of cilia on node cells independently of Foxj1...
  20. pmc Role of the gut endoderm in relaying left-right patterning in mice
    Manuel Viotti
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 10:e1001276. 2012
    ....
  21. pmc Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo
    Ranajeet S Saund
    Department of Neurobiology and Anatomy, University of Utah Medical School, Salt Lake City, UT 84132 3401, USA
    Development 139:2426-35. 2012
    ..Our findings suggest an essential role of endoderm cells in the signal transfer step from the node to the LPM, possibly using gap junction communication to establish the LR axis of the mouse...
  22. pmc Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2
    Satoko Yoshiba
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, 565 0871 Osaka, Japan
    Science 338:226-31. 2012
    ..Our results thus suggest that nodal flow is sensed in a manner dependent on Pkd2 by the cilia of crown cells located at the edge of the node...
  23. pmc BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4
    Milena B Furtado
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    Genes Dev 22:3037-49. 2008
    ..We conclude that BMP/SMAD1 signaling sets a bilateral, repressive threshold for NODAL-dependent Nodal activation in LPM, limiting availability of SMAD4. This repressive threshold is essential for bistable output of the LR system...
  24. ncbi Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice
    R Sharp
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Development 121:149-61. 1995
    ....
  25. ncbi Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse
    Takeshi Fujiwara
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Ave South, Nashville, TN 37232 2175, USA
    Development 129:4685-96. 2002
    ....
  26. ncbi Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists
    Orna Avsian-Kretchmer
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Mol Endocrinol 18:1-12. 2004
    ..into four subgroups based on a conserved arrangement of additional cysteine residues-gremlin and PRDC, cerberus and coco, and DAN, together with USAG-1 and sclerostin...
  27. ncbi ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda
    Renato Mastrangeli
    Industria Farmaceutica Serono S p A Ardea site, 00040, Rome, Italy
    Eur J Dermatol 13:560-70. 2003
    ..The tissue localization and the association with Mal de Meleda suggest that ARS Component B and its protein product SLURP1 are implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin...
  28. pmc Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 103:10300-4. 2006
    ....
  29. ncbi Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
    Kenryo Furushima
    Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology CDB, RIKEN Kobe, 2 2 3 Minatojima minami, Chuo Ku, Kobe 650 0047, Japan
    Dev Biol 306:480-92. 2007
    ....
  30. doi Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner
    Akihiko Ishimura
    The 21st Century Center of Excellence COE Program, Akita University, Akita, Japan
    Dev Dyn 237:3565-76. 2008
    ..These results suggest that Man1 regulates LR asymmetry by controlling Nodal signaling in a node-independent manner...
  31. pmc Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects
    Amit Kumar
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    Dev Dyn 237:3591-601. 2008
    ..No other abnormalities were found, suggesting that Nodal signaling has no additional essential functions in developmental patterning within the extensive mesodermal and endodermal domains marked by T-Cre activity...
  32. doi Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis
    Kylie Lopes Floro
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Hum Mol Genet 20:1097-110. 2011
    ..The clinical relevance of these findings lies in the fact that heterozygous mutation of human CITED2 is associated with congenital heart disease and laterality defects...
  33. doi Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan)
    Robert A White
    Department of Pediatrics, Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Blood Cells Mol Dis 43:141-8. 2009
    ..The identification of the Nan gene will likely uncover a novel protein that contributes to the stability of the EMS and may identify a new mutation for HS...
  34. pmc Pitchfork regulates primary cilia disassembly and left-right asymmetry
    Doris Kinzel
    Institute of Stem Cell Research, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Dev Cell 19:66-77. 2010
    ..Thus, the observation of a disassembly phenotype in vivo provides an entry point to understand and categorize ciliary disease. AUTHOR AUDIO:..
  35. pmc Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2
    Sarah Field
    Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK
    Development 138:1131-42. 2011
    ..Together with co-expression in the node, these data argue that Pkd1l1 is the elusive Pkd2 binding partner required for L-R patterning and support the two-cilia hypothesis...