Cysltr1

Summary

Gene Symbol: Cysltr1
Description: cysteinyl leukotriene receptor 1
Alias: BB147369, CysLT1R, Cyslt1, cysteinyl leukotriene receptor 1, LTD4 receptor, cysteinyl leukotriene 1 receptor short isoform, cysteinyl leukotriene D4 receptor
Species: mouse

Top Publications

  1. ncbi Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors
    V Martin
    Center for Experimental Therapeutics, 814 BRB II III, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Biochem Pharmacol 62:1193-200. 2001
  2. ncbi Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses
    Akiko Maekawa
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 277:20820-4. 2002
  3. ncbi [Rotenone-induced changes of cysteinyl leukotriene receptor 1 expression in BV2 microglial cells]
    Jiang Yun Luo
    Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 40:131-8. 2011
  4. pmc Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing
    A Maekawa
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:2256-61. 2001
  5. pmc Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow
    Tulio Queto
    Department of Pediatrics, Instituto Fernandes Figueira, Rio de Janeiro, Brazil
    J Leukoc Biol 87:885-93. 2010
  6. ncbi Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling
    Yongfeng Jiang
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:2755-9. 2006
  7. pmc CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells
    Yongfeng Jiang
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 110:3263-70. 2007
  8. pmc Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors
    Akiko Maekawa
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16695-700. 2008
  9. pmc P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells
    Yongfeng Jiang
    Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 182:1129-37. 2009
  10. doi Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model
    Sayeh Savari
    Laboratory of Inflammation Biology, Department of Cellular and Molecular Research, National Cancer Centre Singapore, 9 Hospital Drive, Singapore 169612, Singapore and Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Carcinogenesis 37:491-9. 2016

Scientific Experts

  • Yoshihide Kanaoka
  • Taylor Doherty
  • John J Wixted
  • Akiko Maekawa
  • Yongfeng Jiang
  • Joshua A Boyce
  • Wei Ping Zhang
  • Er Qing Wei
  • San Hua Fang
  • Su Su Tang
  • Li Hui Zhang
  • Shu ying Yu
  • Daniela Masid-de-Brito
  • Yun Bi Lu
  • Tulio Queto
  • Sailaja Paruchuri
  • K Frank Austen
  • Sayeh Savari
  • Vinay Kondeti
  • Ursula Storch
  • Jung Sub Park
  • Hui Ji
  • Hao Hong
  • Guo Qing Xiang
  • Hannah E Cummings
  • Sune T Jørgensen
  • Hao Wang
  • Michiko K Oyoshi
  • Jung Min Lee
  • Pedro Xavier-Elsas
  • Wen Zhen Shi
  • Bing Zhao
  • Chun Zhen Zhao
  • Jiang Yun Luo
  • Ashish K Rehni
  • Nora A Barrett
  • Chunli Feng
  • Wei Xing
  • Brian J Bacskai
  • Qian Ding
  • Bing K Lam
  • Wen Wen Sheng
  • Immo Prinz
  • Katharina Lotzer
  • Thomas C Beller
  • Desiree Douglas
  • Janina Osman
  • Ernest Duah
  • Naveen Kumar Chandrashekar
  • Maria Juhas
  • Nosayba Al-Azzam
  • Anita Sjölander
  • Kishan Bellamkonda
  • Sven Pettersson
  • Gunilla Jonsson
  • Charles K Thodeti
  • Gedas Greicius
  • Michael Mederos y Schnitzler
  • Stephanie Blodow
  • Thomas Gudermann
  • Hideaki Ogasawara
  • Sang Myun Park
  • Mi Kyoung Seo
  • Hyun Goo Woo
  • Maria Ignez C Gaspar-Elsas
  • Lu Chen
  • Ning Li
  • Lan Chen
  • Xia yan Zhang
  • Xiao Rong Wang
  • Dong Min Xu
  • Ilo Jou
  • Seo Jun Kang
  • Zhen Lin Mei
  • Miao Jin Ji
  • Li Ying Jiang
  • Li Ping Liu
  • Yong Qi Li
  • Xiaorong Wang
  • Erqing Wei
  • Qiaojuan Shi
  • Else K Hoffmann
  • Ian H Lambert
  • Xiayan Zhang
  • Yan Long
  • Han Ting Zhang
  • Tanya M Laidlaw
  • Heidi N Eriksen
  • Feng Ying Ye
  • Wei Hu

Detail Information

Publications38

  1. ncbi Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors
    V Martin
    Center for Experimental Therapeutics, 814 BRB II III, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Biochem Pharmacol 62:1193-200. 2001
    ..Functional elucidation of mCysLT(1)R properties as described here will enable further experiments to clarify the selective role of LTD(4) in murine models of inflammation and asthma...
  2. ncbi Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses
    Akiko Maekawa
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 277:20820-4. 2002
    ..Thus, the cysLTs generated in vivo by either monocytes/macrophages or mast cells utilize CysLT(1)R for the response of the microvasculature in acute inflammation...
  3. ncbi [Rotenone-induced changes of cysteinyl leukotriene receptor 1 expression in BV2 microglial cells]
    Jiang Yun Luo
    Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 40:131-8. 2011
    To prepare and identify a polyclonal antibody (pAb) against (mouse) cysteinyl leukotriene receptor 1 (CysLT(1)) and to investigate the changes of CysLT(1) receptor expression in BV2 microglial cells after rotenone treatment.
  4. pmc Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing
    A Maekawa
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:2256-61. 2001
    ..Thus, the dominant mouse isoform with the N-terminal amino acid extension encoded by an additional exon has the same ligand response profile as the spliced form and the human receptor...
  5. pmc Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow
    Tulio Queto
    Department of Pediatrics, Instituto Fernandes Figueira, Rio de Janeiro, Brazil
    J Leukoc Biol 87:885-93. 2010
    ..were evaluated, in the absence or presence of: a) the 5-LO inhibitor zileuton, the FLAP inhibitor MK886, or the CysLT1R antagonists, montelukast and MK571; b) mutations that inactivate 5-LO, LTC4S, or CysLT1R; and c) neutralizing mAb ..
  6. ncbi Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling
    Yongfeng Jiang
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:2755-9. 2006
    ..that IL-4, which induces LTC4S expression by mast cells (MCs), requires cys-LTs, the cys-LT type 1 receptor (CysLT1), and Gi proteins to promote MC proliferation...
  7. pmc CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells
    Yongfeng Jiang
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 110:3263-70. 2007
    ..Negative regulation of CysLT(1)-induced mitogenic signaling responses of MCs by CysLT(2) demonstrates physiologically relevant functions for GPCR heterodimers on primary cells central to inflammation...
  8. pmc Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors
    Akiko Maekawa
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16695-700. 2008
    ..Our findings establish the existence of a third receptor, CysLT(E)R, that responds preferentially to LTE(4), the most abundant cys-LT in biologic fluids, and thus reveal a new target for therapeutic intervention...
  9. pmc P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells
    Yongfeng Jiang
    Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 182:1129-37. 2009
    Cysteinyl leukotrienes (cys-LTs) induce inflammatory responses through type 1 (CysLT1R) and type 2 (CysLT2R) cys-LT receptors and activate mast cells in vitro...
  10. doi Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model
    Sayeh Savari
    Laboratory of Inflammation Biology, Department of Cellular and Molecular Research, National Cancer Centre Singapore, 9 Hospital Drive, Singapore 169612, Singapore and Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Carcinogenesis 37:491-9. 2016
    ..Increased expression of both the cysteinyl leukotriene receptor 1 (CysLTR1) and the enzyme responsible for the production of leukotrienes, 5-lipoxygenase, is ..
  11. doi Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice
    Wen Zhen Shi
    Institute of Neuroscience and Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China
    Neurosci Bull 28:680-92. 2012
    ..Aquaporin-4 (AQP4), the main water channel protein in the brain, plays a critical role in water homeostasis and brain edema. Here, we investigated its role in the inflammatory responses after focal cerebral ischemia...
  12. doi Leukotriene D4 induces cognitive impairment through enhancement of CysLT₁ R-mediated amyloid-β generation in mice
    Su Su Tang
    Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, PR China
    Neuropharmacology 65:182-92. 2013
    ..LTD4 also induced expression of cysteinyl leukotriene receptor 1 (CysLT(1)R) and NF-κB p65 in the hippocampus and cortex. Pretreatment with pranlukast (1...
  13. pmc Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro
    Shu ying Yu
    1 Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China 2 Department of Pharmacology, Hangzhou Pediatric Hospital, Hangzhou 310004, China
    Acta Pharmacol Sin 35:33-40. 2014
    To investigate the roles of cysteinyl leukotriene receptors CysLT1R and CysLT2R in leukotriene D4 (LTD4)-induced activation of microglial cells in vitro.
  14. pmc Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor
    Hannah E Cummings
    Jeff and Penny Vinik Center for Allergic Disease Research, Boston, MA 02115
    J Immunol 191:5807-10. 2013
    ..They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences...
  15. pmc GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4
    Akiko Maekawa
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:11685-90. 2009
    ..Taken together, our findings suggest that GPR17 is a ligand-independent, constitutive negative regulator for the CysLT(1)R that suppresses CysLT(1)R-mediated function at the cell membrane...
  16. doi Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo
    Su Su Tang
    Department of Pharmacology, China Pharmaceutical University, Nanjing, China
    Neurobiol Aging 35:590-9. 2014
    ..In the current study, we investigated the roles of cysteinyl leukotriene receptor 1 (CysLT1R) in Aβ1-42-induced neurotoxicity in vitro or in vivo...
  17. pmc Role of cysteinyl leukotriene signaling in a mouse model of noise-induced cochlear injury
    Jung Sub Park
    Department of Pharmacology, Department of Otolaryngology, Neuroscience Graduate Program, Department of Biological Sciences, Chronic Inflammatory Disease Research Center, and
    Proc Natl Acad Sci U S A 111:9911-6. 2014
    ..We found that the expression of cysteinyl leukotriene type 1 receptor (CysLTR1) was increased until 3 d after noise exposure and enhanced CysLTR1 expression was mainly observed in the spiral ..
  18. doi Cysteinyl leukotriene 1 receptors as novel mechanosensors mediating myogenic tone together with angiotensin II type 1 receptors-brief report
    Ursula Storch
    From the Walther Straub Institute of Pharmacology and Toxicology U S, S B, T G, M MyS, Ludwig Maximilians University of Munich, Munich, Germany and DZHK German Centre for Cardiovascular Research, partner site Munich Heart Alliance T G, M MyS, Munich, Germany
    Arterioscler Thromb Vasc Biol 35:121-6. 2015
    ..Therefore, we aimed at uncovering novel vascular mechanosensors by expression profiling and functional characterization of candidate proteins...
  19. pmc Roles of 5-lipoxygenase and cysteinyl-leukotriene type 1 receptors in the hematological response to allergen challenge and its prevention by diethylcarbamazine in a murine model of asthma
    Daniela Masid-de-Brito
    Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, 21 941 590 Rio de Janeiro, RJ, Brazil
    Mediators Inflamm 2014:403970. 2014
    ..Overall, 5-LO appears as indispensable to the systemic hematological response to allergen challenge, as well as to the effectiveness of DEC. ..
  20. ncbi The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells
    Immo Prinz
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Université de la Méditerranée, Parc Scientifique de Luminy, Marseille, France
    J Immunol 175:713-9. 2005
    ..These results suggest that CysLT(1) is likely involved in the recruitment of activated alphabeta and gammadelta T cells to inflamed tissues...
  21. pmc Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis
    Thomas C Beller
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:3047-52. 2004
    ....
  22. doi Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3
    Vinay Kondeti
    Department of Chemistry, University of Akron, Akron, Ohio
    J Allergy Clin Immunol 137:289-98. 2016
    ....
  23. pmc Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production
    Taylor A Doherty
    Department of Medicine, University of California, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 132:205-13. 2013
    Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered lineage-negative type 2 innate lymphoid cells (ILC2s) potently produce IL-5 and IL-13.
  24. pmc Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis
    Michiko K Oyoshi
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:4992-7. 2012
    ..Strategies that block eosinophil infiltration, cys-LT production, or the CysLT(2)R might be useful in the treatment of AD...
  25. doi 5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1
    Jung Min Lee
    College of Pharmacy, Sookmyung Women s University, Seoul 140 742, Republic of Korea
    J Immunol 189:5284-92. 2012
    ..Similar effects were shown with CysLT receptor (CysLTR)1/2 antagonist and small RNA for CysLTR1 in BMMs, indicating the involvement of CysLT and CysLTR1 in 5-LO-mediated osteoclastogenesis...
  26. doi Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization
    Sune T Jørgensen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 31:366-78. 2013
    ..via CysLT1 is involved in activation of volume sensitive K(+) channels and homologous desensitization of the LTD4 receptor impairs regulatory volume decrease (RVD)...
  27. pmc Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand
    Yoshihide Kanaoka
    Department of Medicine, Harvard Medical School and the Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 288:10967-72. 2013
    ..b>Cysltr1/Cysltr2(-/-) mice, lacking the two defined receptors, exhibited a comparable dose-dependent vascular leak to ..
  28. ncbi [Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice]
    Hao Wang
    Department of Neurology, Tongde Hospital of Zhejiang Province, Hangzhou, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 42:52-60. 2013
    To examine the spatiotemporal profiles and localization of CysLT1R, CysLT2R and GPR17 in mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD).
  29. pmc Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes
    Nora A Barrett
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 208:593-604. 2011
    ..with Df-pulsed BMCs(GM-CSF) from LTC(4) synthase (LTC(4)S)-deficient mice or type 1 cys-LT receptor (CysLT1R)-deficient mice demonstrated that both proteins were required for Df-elicited eosinophilic pulmonary inflammation ..
  30. doi Modulation of leukotriene D4 attenuates the development of seizures in mice
    Ashish K Rehni
    Chitkara College of Pharmacy, Chandigarh Patiala National Highway, Patiala, Punjab, India
    Prostaglandins Leukot Essent Fatty Acids 85:97-106. 2011
    ..Therefore, leukotriene D(4) may be implicated in the pathogenesis of seizures...
  31. pmc GPR17 regulates immune pulmonary inflammation induced by house dust mites
    Akiko Maekawa
    Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 185:1846-54. 2010
    ..These findings reveal a constitutive negative regulation of CysLT(1)R functions by GPR17 in both the Ag presentation and downstream phases of allergic pulmonary inflammation...
  32. pmc Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor
    Sailaja Paruchuri
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:2543-55. 2009
    ..Although LTE4 shows negligible activity at the type 1 and 2 receptors for cys-LTs (CysLT1R and CysLT2R), it is a powerful inducer of mucosal eosinophilia and airway hyperresponsiveness in humans with ..
  33. pmc Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor
    John J Wixted
    Department of Orthopedic Surgery and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 221:31-9. 2009
    ....
  34. ncbi Cysteinyl leukotriene receptor 1 partially mediates brain cryoinjury in mice
    Qian Ding
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China
    Acta Pharmacol Sin 28:945-52. 2007
    To determine whether the cysteinyl leukotriene receptor 1 (CysLT1 receptor) modulates brain cryoinjury and whether the CysLT1 receptor antagonist pranlukast exerts a time-dependent protective effect on cryoinjury in mice.
  35. ncbi Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death
    Wen Wen Sheng
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China
    Biochem Biophys Res Commun 346:19-25. 2006
    ..Thus, CysLT(1) and CysLT(2) receptors play distinct roles in OGD-induced PC12 cell death; CysLT(1) attenuates while CysLT(2) facilitates the cell death...
  36. ncbi The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis
    Katharina Lotzer
    Institute for Vascular Medicine, Friedrich Schiller University of Jena, Bachstr 18, 07743 Jena, Germany
    Biochim Biophys Acta 1736:30-7. 2005
    ..We will attempt to propose strategies to further explore potential links between the 5-LO pathway and blood vessel physiology and disease progression...
  37. ncbi Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution
    Hideaki Ogasawara
    Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Biol Chem 277:18763-8. 2002
    ....
  38. ncbi Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes
    J Mollerup
    Institut of Molecular Biology, Department of Molecular Cell Biology, Copenhagen, Denmark
    Biochim Biophys Acta 1517:455-9. 2001
    ..The identified murine CysLT1 receptor differs from the hCysLT1 receptor with regard to PTX sensitivity, receptor-mediated Ca2+ influx, and ..