cyclooxygenase 2

Summary

Gene Symbol: cyclooxygenase 2
Description: prostaglandin-endoperoxide synthase 2
Alias: COX2, Cox-2, PES-2, PGHS-2, PHS II, PHS-2, Pghs2, TIS10, gripghs, prostaglandin G/H synthase 2, PGH synthase 2, cyclooxygenase-2, glucocorticoid-regulated inflammatory cyclooxygenase, macrophage activation-associated marker protein P71/73, prostaglandin H2 synthase 2
Species: mouse

Top Publications

  1. ncbi Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene
    Tomo o Ishikawa
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Genesis 44:143-9. 2006
  2. pmc Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
    J Clin Invest 109:1405-15. 2002
  3. ncbi Prostaglandin synthase 2
    H R Herschman
    Department of Biological Chemistry, UCLA 90095, USA
    Biochim Biophys Acta 1299:125-40. 1996
  4. ncbi Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent
    Vibha Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor 48109 0642, USA
    Am J Respir Cell Mol Biol 27:752-8. 2002
  5. ncbi Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning
    M G Camitta
    NIEHS, NIH, Research Triangle Park, Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC, USA
    Circulation 104:2453-8. 2001
  6. pmc Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus
    Charles D Loftin
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 110:549-57. 2002
  7. ncbi Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
    R G Kurumbail
    G D Searle, St Louis, Missouri 63198, USA
    Nature 384:644-8. 1996
  8. pmc Host cyclooxygenase-2 modulates carcinoma growth
    C S Williams
    Department of Medicine, The Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
    J Clin Invest 105:1589-94. 2000
  9. ncbi Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    P C Chulada
    Laboratory of Experimental Carcinogenesis and Mutagenesis, NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 60:4705-8. 2000
  10. pmc Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2
    Louise Y Y Fong
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Int J Cancer 122:978-89. 2008

Detail Information

Publications174 found, 100 shown here

  1. ncbi Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene
    Tomo o Ishikawa
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Genesis 44:143-9. 2006
    ..Spatially and temporally restricted elimination of the Cox-2 gene in Cox-2(flox/flox) conditional knockout mice should provide a valuable tool to analyze the cell type-specific role of Cox-2 in many disease models...
  2. pmc Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
    J Clin Invest 109:1405-15. 2002
    ..These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair...
  3. ncbi Prostaglandin synthase 2
    H R Herschman
    Department of Biological Chemistry, UCLA 90095, USA
    Biochim Biophys Acta 1299:125-40. 1996
  4. ncbi Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent
    Vibha Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor 48109 0642, USA
    Am J Respir Cell Mol Biol 27:752-8. 2002
    ..These alterations in AEC phenotype likely contribute to the propensity for pulmonary fibrosis observed in COX-2-deficient mice...
  5. ncbi Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning
    M G Camitta
    NIEHS, NIH, Research Triangle Park, Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC, USA
    Circulation 104:2453-8. 2001
    ....
  6. pmc Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus
    Charles D Loftin
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 110:549-57. 2002
    ..Therefore, COX-1-selective inhibitors may provide effective treatment to delay preterm labor with fewer adverse effects on fetal or neonatal health than nonselective or COX-2-selective inhibitors...
  7. ncbi Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
    R G Kurumbail
    G D Searle, St Louis, Missouri 63198, USA
    Nature 384:644-8. 1996
    ..0 to 2.5 A resolution. These structures explain the structural basis for the selective inhibition of COX-2, and demonstrate some of the conformational changes associated with time-dependent inhibition...
  8. pmc Host cyclooxygenase-2 modulates carcinoma growth
    C S Williams
    Department of Medicine, The Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
    J Clin Invest 105:1589-94. 2000
    ..Additionally, treatment of wild-type mouse fibroblasts with a selective COX-2 inhibitor reduced VEGF production by 92%...
  9. ncbi Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    P C Chulada
    Laboratory of Experimental Carcinogenesis and Mutagenesis, NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 60:4705-8. 2000
    ..The results indicate that COX-1, as well as COX-2, plays a key role in intestinal tumorigenesis and that COX-1 may also be a chemotherapeutic target for nonsteroidal anti-inflammatory drugs...
  10. pmc Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2
    Louise Y Y Fong
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Int J Cancer 122:978-89. 2008
    ..Thus, targeting only the COX-2 pathway in zinc-deficient animals did not prevent UADT carcinogenesis. Our data suggest zinc supplementation should be more thoroughly explored in human prevention clinical trials for UADT cancer...
  11. ncbi Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
    J E Dinchuk
    DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880 0400, USA
    Nature 378:406-9. 1995
    ..Female Cox-2-/- mice were infertile. COX-2 deficiency failed to alter inflammatory responses in several standard models, but striking mitigation of endotoxin-induced hepatocellular cytotoxicity was observed...
  12. pmc Compensatory prostaglandin E2 biosynthesis in cyclooxygenase 1 or 2 null cells
    K Kirtikara
    Department of Medicine, The University of Tennessee, Memphis, Tennessee 38163, USA
    J Exp Med 187:517-23. 1998
    ..in immortalized, nontransformed cells derived from wild-type, cyclooxygenase 1-deficient (COX-1(-/-)) or cyclooxygenase 2-deficient (COX-2(-/-)) mice was examined after treatment with interleukin (IL)-1beta, tumor necrosis factor ..
  13. ncbi The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice
    S Li
    Department of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USA
    Brain Res 825:86-94. 1999
    ..By contrast, COX-2+/- and COX-2-/- mice displayed no Tc rise after LPS. PFS did not affect the Tc of any animal. It would appear therefore that COX-2 is necessary for LPS-induced fever production...
  14. ncbi Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurophysiol 87:2851-7. 2002
    ..Our results indicate that COX-2-generated PGE2 regulates membrane excitability and long-term synaptic plasticity in hippocampal perforant path-dentate gyrus synapses...
  15. ncbi Transcriptional regulation of cyclooxygenase-2 gene in pancreatic beta-cells
    Fan Yang
    Susan and Leslie Gonda Goldschmied Diabetes and Genetic Research Center, Department of Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, Duarte, California 91010, USA
    J Biol Chem 279:35403-11. 2004
    ..We consider these three transcriptional regulators of COX-2 expression to be potential targets for the prevention of beta-cell damage mediated by PGE(2)...
  16. pmc Alteration of femoral bone morphology and density in COX-2-/- mice
    Galen Robertson
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Bone 39:767-72. 2006
    ..In conclusion, our study suggests that genetic ablation of COX-2 may have a sex-related effect on cortical bone homeostasis and COX-2 plays a role in maintaining normal bone micro-architecture and density in mice...
  17. pmc Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 8:R14. 2007
    ....
  18. pmc Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-kappaB dependent pathway
    Qianhong Li
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
    Circulation 116:1577-84. 2007
    ..Accordingly, we used genetically engineered mice to test the hypothesis that the cardioprotection afforded by iNOS gene transfer is mediated by COX-2 upregulation via a nuclear factor (NF)-kappaB-dependent pathway...
  19. doi Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages
    Ji Yeon Kim
    Department of Pharmaceutical Biochemistry, Kyung Hee University, Dongdaemun ku, Hoegi dong, Seoul 130 701, South Korea
    Eur J Pharmacol 584:175-84. 2008
    ..These results suggest that the anti-inflammatory properties of ILG are caused by iNOS, COX-2, TNF-alpha, and IL-6 down-regulation due to NF-kappaB inhibition via the suppression of IKK, ERK1/2 and p38 phosphorylation in RAW 264.7 cells...
  20. doi Arachidonic acid release by H2O2 mediated proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC and MAPKs-induced EGFR transactivation
    Sang Hun Lee
    Department of Veterinary Physiology, Biotherapy Human Resources Center BK 21, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, South Korea
    J Cell Biochem 106:787-97. 2009
    ..In conclusion, H(2)O(2) increased AA release and PGE(2) production by the upregulation of cPLA(2) and COX-2 via Ca(2+)/PKC/MAPKs and EGFR transactivation, subsequently proliferation of mouse ES cells...
  21. doi Renal and cardiovascular characterization of COX-2 knockdown mice
    Francesca Seta
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 296:R1751-60. 2009
    ..COX-2(Neo/Neo) mice, therefore, provide a genetic surrogate of coxib therapy with disrupted prostacyclin biosynthesis that predisposes to induced arterial thrombosis...
  22. ncbi A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein
    M K O'Banion
    Department of Medicine and Biochemistry, University of Rochester School of Medicine and Dentistry, New York 14642
    J Biol Chem 266:23261-7. 1991
    ....
  23. ncbi Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    M Oshima
    Banyu Tsukuba Research Institute Merck, Okubo, Japan
    Cell 87:803-9. 1996
    ..These results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis and indicate that COX-2-selective inhibitors can be a novel class of therapeutic agents for colorectal polyposis and cancer...
  24. ncbi Renin expression in COX-2-knockout mice on normal or low-salt diets
    T Yang
    National Institute of Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Am J Physiol Renal Physiol 279:F819-25. 2000
    ....
  25. pmc Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
    ..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...
  26. ncbi Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse)
    Valentina Campean
    Anatomisches Institut, Charite, Humboldt Universitat, Berlin, Germany
    Am J Physiol Renal Physiol 285:F19-32. 2003
    ....
  27. ncbi Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney
    Andre Schneider
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1205-13. 2004
    ..The present studies were aimed at determining the intrarenal localization of mPGES-1 and whether it is coexpressed with COX-1 or COX-2...
  28. ncbi Endotoxin-induced uveitis in cyclooxygenase-2-deficient mice
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:2306-13. 2004
    ..The purpose of this study was to delineate the role of COX-2 in acute ocular inflammation...
  29. ncbi Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages
    Tzeng Horng Leu
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
    Mol Immunol 43:308-16. 2006
    ..7 and animal models of sepsis greatly suppresses TNFalpha secretion and serum TNFalpha level, respectively. Therefore, we conclude that c-Src, with its LPS induction, has an unperceived role in transmitting LPS signaling in macrophages...
  30. ncbi Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouse
    Jagadeesh S Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 9, Room 1S 128, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 139:217-24. 2005
    ..Overall, our data indicate that constitutive brain NF-kappaB activity is decreased in COX-2 deficient mice and suggest a reciprocal coupling between NF-kappaB and COX-2...
  31. ncbi Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 0947, USA
    J Neurochem 96:669-79. 2006
    ..This response likely reflects selective COX-2-mediated conversion of PLA2-released AA to prostanoids...
  32. ncbi Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity
    Takayuki Kawano
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Med 12:225-9. 2006
    ..An EP1 receptor inhibitor reduces brain injury when administered 6 hours after MCA occlusion, suggesting that EP1 receptor inhibition may be a viable therapeutic option in ischemic stroke...
  33. ncbi Role of MAPK in the regulation of double-stranded RNA- and encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages
    Sarah A Steer
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, MO 63104, USA
    J Immunol 177:3413-20. 2006
    ..These findings support a role for p38 and JNK in the selective regulation of COX-2 expression by macrophages in response to virus infection...
  34. pmc Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice
    Muzamil Ahmad
    Geriatric Research Educational and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
    J Neurosci Res 86:3605-12. 2008
    ..COX-2 gene disruption did not alter Morris water maze performance. Taken together, these results suggest only a minor role for COX-2 activity in determining outcome after TBI in mouse...
  35. pmc cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase
    M K O'Banion
    Department of Medicine, University of Rochester School of Medicine and Dentistry, NY 14642
    Proc Natl Acad Sci U S A 89:4888-92. 1992
    ..1-kb, but not the 2.8-kb, mRNA is greatly superinduced. Thus, there are both constitutive (2.8 kb) and regulated (4.1 kb) cyclooxygenase species, the latter most likely being a major mediator of inflammation...
  36. ncbi TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
    D A Kujubu
    Department of Biological Chemistry, UCLA School of Medicine 90024
    J Biol Chem 266:12866-72. 1991
    b>TIS10 is a primary response gene whose cDNA was cloned as a result of its rapid, superinducible expression in Swiss 3T3 cells in response to 12-O-Tetradecanoylphorbol-13-acetate. The 5'-untranslated region of the 3...
  37. ncbi Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
    S G Morham
    Department of Pathology, University of North Carolina at Chapel Hill 27599 7525, USA
    Cell 83:473-82. 1995
    The prostaglandin endoperoxide H synthase isoform 2, cyclooxygenase 2 (COX-2), is induced at high levels in migratory and other responding cells by pro-inflammatory stimuli. COX-2 is generally considered to be a mediator of inflammation...
  38. ncbi Multiple female reproductive failures in cyclooxygenase 2-deficient mice
    H Lim
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
    Cell 91:197-208. 1997
    ....
  39. ncbi Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms
    R L Shattuck-Brandt
    Department of Cell Biology, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Mol Carcinog 24:177-87. 1999
    ....
  40. ncbi Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis
    R Langenbach
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 889:52-61. 1999
    ..Furthermore, data from COX-deficient mice indicate that both isoforms can contribute to the inflammatory response and that both isoforms have significant roles in carcinogenesis...
  41. pmc Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
    O Morteau
    Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 105:469-78. 2000
    ....
  42. pmc Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
    C Iadecola
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 98:1294-9. 2001
    ..Thus, COX-2 is involved in pathogenic events occurring in both the early and late stages of cerebral ischemia and may be a valuable therapeutic target for treatment of human stroke...
  43. ncbi Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice
    C H Liu
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 276:18563-9. 2001
    ..These data indicate that enhanced Cox-2 expression is sufficient to induce mammary gland tumorigenesis. Therefore, inhibition of Cox-2 may represent a mechanism-based chemopreventive approach for carcinogenesis...
  44. pmc Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice
    C B Keerthisingam
    Centre for Cardiopulmonary Biochemistry and Respiratory Medicine, Royal Free and University College London Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ, United Kingdom
    Am J Pathol 158:1411-22. 2001
    ....
  45. ncbi Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus
    N T Schwarz
    Department of Medicine Gastroenterology, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Gastroenterology 121:1354-71. 2001
    ..This study demonstrates a significant role for cyclooxygenase (COX)-2 and prostanoid production as mechanisms for surgically induced postoperative ileus...
  46. ncbi Many actions of cyclooxygenase-2 in cellular dynamics and in cancer
    Yang Cao
    Huntsman Cancer Institute, University of Utah, Salt Lake City 84112, USA
    J Cell Physiol 190:279-86. 2002
    ..Inhibition of COX-2 promises to be an effective approach in the prevention and treatment of cancer, especially colorectal cancer...
  47. ncbi Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Endocrinology 143:2410-9. 2002
    ..These results show that mPGES-1 is expressed coordinately with COX-1 and COX-2 and is involved in PGE(2) production in male genital organs...
  48. ncbi Cyclo-oxygenase 2 function is essential for bone fracture healing
    Ann Marie Simon
    Department of Orthopaedics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    J Bone Miner Res 17:963-76. 2002
    ..Because mice lacking Cox2 form normal skeletons, our observations indicate that fetal bone development and fracture healing are different and ..
  49. ncbi Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis
    Howard F Tiano
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 62:3395-401. 2002
    ..Thus, both COX-1 and COX-2 have roles in keratinocyte differentiation, and we propose that the absence of either isoform causes premature terminal differentiation of initiated keratinocytes and reduced tumor formation...
  50. ncbi Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo
    Daichi Chikazu
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    J Bone Miner Res 17:1430-40. 2002
    ....
  51. ncbi Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity
    Dayong Wu
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 278:10983-92. 2003
    ..These findings strongly suggest that the age-associated and ceramide-induced increase in COX-2 transcription is mediated through higher NF-kappa B activation, which is, in turn, because of a greater I kappa B degradation in old M phi...
  52. ncbi Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2
    Debnath Mukhopadhyay
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell 11:113-26. 2003
    ..These findings identify a novel paradigm for RNA binding proteins in facilitating opposing functions of mRNA stability and translation inhibition and reveal a mechanism for inhibiting COX-2 expression in cancer cells...
  53. ncbi Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death
    Kuniaki Ejima
    Brigham and Women s Hospital, Pulmonary and Critical Care Medicine, 75 Francis St, Boston, MA 02115, USA
    FASEB J 17:1325-7. 2003
    ..These beneficial effects occur, in part, by a compensatory increase in IL-10 that counterbalances the pro-inflammatory host response to endotoxemia...
  54. ncbi Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy
    F Sennlaub
    Department of Pediatrics, Centre de Recherche, Hopital Sainte Justine, 3175, Chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Circulation 108:198-204. 2003
    ..Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)-2 promotes tumor angiogenesis, we investigated the role of COX-2 in ischemic proliferative retinopathy...
  55. ncbi Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 278:37937-47. 2003
    ..Collectively, mPGES-2 is a unique PGES that can be coupled with both COXs and may play a role in the production of the PGE2 involved in both tissue homeostasis and disease...
  56. ncbi COX-2-deficient mice are less prone to MPTP-neurotoxicity than wild-type mice
    Zhehui Feng
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Neuroreport 14:1927-9. 2003
    ..Inhibition of COX-2 protein expression decreased the lesion caused by MPTP and protected the dopaminergic neurons in substantia nigra pars compacta. This result suggested that inhibition of COX-2 has potential therapeutic implications...
  57. pmc JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease
    Stephane Hunot
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:665-70. 2004
    ..Our data revealed that JNK2- and JNK3-induced COX-2 may be a principle pathway responsible for neurodegeneration in PD...
  58. ncbi The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 87:1471-7. 2003
    ..This suggests that cPLA2 is critical for COX-2-derived eicosanoid production in mouse brain...
  59. ncbi Inhibition of nNOS expression in the macula densa by COX-2-derived prostaglandin E(2)
    Alex Paliege
    National Institute of Diabetes and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 287:F152-9. 2004
    ..Furthermore, the inhibitory effect of PGE(2) on nNOS mRNA expression indicates a novel interaction between NO and prostaglandin-mediated pathways of renin regulation...
  60. pmc Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice
    Hiroko Oshima
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    EMBO J 23:1669-78. 2004
    ..Furthermore, Helicobacter infection upregulated epithelial PGE2 production, suggesting that the COX-2/mPGES-1 pathway contributes to the Helicobacter-associated gastric tumorigenesis...
  61. pmc Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production
    Rebecca J Hodges
    Centre for Respiratory Research, University College London, Rayne Bldg, 5 University St, London WC1E 6JJ, UK
    Am J Pathol 165:1663-76. 2004
    ..These data provide further direct evidence for the importance of up-regulating COX-2 and PGE(2) expression in protecting against the development of fibrosis after lung injury...
  62. ncbi COX-2-derived prostacyclin confers atheroprotection on female mice
    Karine M Egan
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA 19104, USA
    Science 306:1954-7. 2004
    ..receptor subtype alpha to up-regulate the production of atheroprotective prostacyclin, PGI2, by activation of cyclooxygenase 2 (COX-2)...
  63. ncbi Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 91:1389-97. 2004
    ..Overall, the data suggest that compensatory mechanisms exist in COX-2(-/-) mice and that mPGES-2 is functionally coupled with COX-2...
  64. ncbi Hypergravity induces expression of cyclooxygenase-2 in the heart vessels
    Masanobu Oshima
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 330:928-33. 2005
    ..Therefore, COX-2 induced in the heart helps protect the heart function against hypoxia under hypergravity condition through HIF-1alpha induction...
  65. ncbi Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer
    Jinyi Shao
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:26565-72. 2005
    ....
  66. pmc Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning
    Yu Ting Xuan
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circulation 112:1971-8. 2005
    ....
  67. ncbi HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, NY, USA
    Cancer Res 65:10113-9. 2005
    ..This finding may help to explain the reduced risk of breast cancer associated with regular use of nonsteroidal anti-inflammatory drugs...
  68. ncbi Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
    Sangwon F Kim
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 310:1966-70. 2005
    ..Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs...
  69. ncbi COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis
    Gladson Muthian
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Immunol 26:73-85. 2006
    ....
  70. ncbi COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis
    Alysia Kern Lovgren
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 27599, USA
    Am J Physiol Lung Cell Mol Physiol 291:L144-56. 2006
    ..If such protection is observed, investigation of these agents as a novel therapeutic approach to pulmonary fibrosis in humans may be warranted...
  71. ncbi Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, 341 Boyer Hall, 611 Charles E Young Drive East, UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 8:171-87. 2006
    ..Cox-2luc/+ knock-in mice should provide a valuable tool to analyze Cox-2 expression in many disease models...
  72. pmc Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
    Yan Cheng
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:1391-9. 2006
    ..These results suggest that inhibitors of mPGES-1 may retain their antiinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences associated with PGHS-2-mediated PGI(2) suppression...
  73. ncbi Genetic model of selective COX2 inhibition reveals novel heterodimer signaling
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 421 Curie Boulevard, BRB II III, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:699-704. 2006
    ..These drugs block the cyclooxygenase activity of prostaglandin H synthase-2 (PGHS2), but do not affect the associated peroxidase function...
  74. pmc Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis
    Sang Ho Choi
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 98:801-11. 2006
    ..Additionally, COX-1 deficiency can affect the expression of reciprocal and coupled enzymes, COX-2, Ca2+ -dependent PLA2, and terminal mPGES-2, to overcome defects in brain AA cascade...
  75. pmc Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Division of Gastroenterology, New York, New York, USA
    Gastroenterology 131:862-77. 2006
    ..We wished to test the hypothesis that cyclooxygenase 2 (Cox-2)-derived prostaglandin E2 (PGE2) is important in TLR4-related mucosal repair.
  76. ncbi The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system
    Uri R Mbonye
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 281:35770-8. 2006
    ..Finally, kifunensine, a mannosidase inhibitor that can block entry of ER proteins into the ER-associated degradation system, retards COX-2 degradation...
  77. pmc cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis
    Alysia Kern Lovgren
    University of North Carolina, Department of Genetics, Chapel Hill, NC 27599, USA
    Mol Cell Biol 27:4416-30. 2007
    ....
  78. pmc Cyclooxygenase-2 gene disruption promotes proliferation of murine calvarial osteoblasts in vitro
    Zheng Xu
    Department of Medicine, Room N4051, MARB, MC5456, University of Connecticut Health Center, Farmington, 263 Farmington Avenue, Farmington, CT 06030, USA
    Bone 41:68-76. 2007
    ..We conclude that PGs secondary to COX-2 expression decrease osteoblastic proliferation in cultured calvarial cells but increase growth of osteoblastic precursors in MSC cultures...
  79. ncbi Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal
    Masaya Kanayama
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 282:24166-74. 2007
    ..These findings represent a demonstration of a link between lipoprotein modification and activation of the inflammatory potential of macrophages...
  80. pmc A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors
    Ajay Narasimha
    Department of Molecular and Medical Pharmacology, University of California Los Angeles, CA, United States
    Prostaglandins Other Lipid Mediat 84:24-33. 2007
    ..Our results suggest, for the first time, that COX-2 deficiency contributes to the pro-atherogenic properties of HDL in mice...
  81. pmc Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Brain Res Bull 75:598-609. 2008
    ..Our results suggest that PTGS-2 activity and its specific products may modulate neuronal excitability by affecting GABAergic neurotransmission. Further, inhibition of PTGS-2, but not PTGS-1, may increase the susceptibility to seizures...
  82. doi Cyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis
    Mary Clare Cathcart
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons Ireland, Dublin, Ireland
    J Pharmacol Exp Ther 326:51-8. 2008
    ..The data provide evidence that endogenous prostaglandins modulate the pulmonary response to hypoxia...
  83. pmc Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells
    Laura E Fredenburgh
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 117:2114-22. 2008
    ..Selective COX-2 inhibition may have detrimental pulmonary vascular consequences during hypoxia...
  84. pmc Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2
    Saba Aid
    Brain Physiology and Metabolism Section, National Institute on Aging, NIH, 9000 Memorial Drive, Bldg 9 Room 1S126, Bethesda, MD 20892, USA
    J Neuroinflammation 5:17. 2008
    ..Recently, we demonstrated that COX-1 deficient mice show decreased neuroinflammatory response and neuronal damage in response to lipopolysaccharide (LPS)...
  85. pmc Reduced COX-2 expression in aged mice is associated with impaired fracture healing
    Amish A Naik
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 24:251-64. 2009
    The cellular and molecular events responsible for reduced fracture healing with aging are unknown. Cyclooxygenase 2 (COX-2), the inducible regulator of prostaglandin E(2) (PGE(2)) synthesis, is critical for normal bone repair...
  86. pmc TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage
    Tiffany Moses
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Leukoc Biol 86:971-80. 2009
    ..Together, these data indicate that TLR4 stimulation of Cox-2 activation of PGE2 production is necessary but not sufficient for intestinal IR-induced damage and inflammation...
  87. pmc Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4
    Chao Xie
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Pathol 175:772-85. 2009
    ..Taken together, our studies demonstrate that EP2 and EP4 have differential functions during endochondral bone repair. Activation of EP4, but not EP2 rescued impaired bone fracture healing in COX-2(-/-) mice...
  88. pmc Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2
    Kyriakos N Papanicolaou
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Mol Cell Cardiol 49:196-209. 2010
    ..In conclusion, our animal-based analyses together with the cell-based observations portray a limited role of cardiomyocyte-produced Cox-2 at baseline and in the context of ischemic or hemodynamic challenge...
  89. pmc Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production
    Marion Man Ying Chan
    Department of Microbiology and Immunology, School of Medicine, Temple University, Philadelphia, PA 19140, USA
    J Immunol 184:6418-26. 2010
    ..These findings may explain the enigma regarding why COX-2 inhibitors are palliative rather than curative in humans, because blocking resolution may mitigate the benefit of preventing induction...
  90. pmc Targeted deletions of cyclooxygenase-2 and atherogenesis in mice
    Yiqun Hui
    School of Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 153 Johnson Pavilion, Philadelphia, PA 19104, USA
    Circulation 121:2654-60. 2010
    ..Floxed mice were used to parse distinct cellular contributions of COX-2 in macrophages and T cells (TCs) to atherogenesis...
  91. doi Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages
    Manuel D Díaz-Muñoz
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Biochem J 443:451-61. 2012
    ..the involvement of PGE receptors [EPs (E-prostanoids)] showed that incubation with EP2 agonists up-regulated both COX2 and mPGES-1 mRNA levels...
  92. pmc Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
    Susan Parazzoli
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Biol Chem 287:32246-53. 2012
    ..IL-1β inhibited glucose-stimulated insulin secretion equally in both WT and mPGES-1(-/-) islets, indicating that COX-2, not mPGES-1, mediates IL-1β-induced PGE(2) production and subsequent inhibition of insulin secretion...
  93. pmc Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
    Nicholas S Kirkby
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
    Proc Natl Acad Sci U S A 109:17597-602. 2012
    ....
  94. pmc Prostaglandin E2 acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro
    Shilpa Choudhary
    New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 56:31-41. 2013
    ..This suppression of OB differentiation could contribute to the bone loss seen with continuous PTH in vivo...
  95. pmc Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
    C D Loftin
    Laboratory of Environmental Carcinogenesis and Mutagenesis, Comparative Medicine Branch, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 98:1059-64. 2001
    ..Together, these data establish roles for COX-1, and especially for COX-2, in the transition of the cardiopulmonary circulation at birth...
  96. ncbi Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury
    Hao Yin
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hepatology 45:159-69. 2007
    ..These findings suggest that COX-2-derived PGs may have great therapeutic potentials in treating patients with inflammatory liver diseases...
  97. ncbi Regulated expression of prostaglandin endoperoxide synthase-2 by uterine stroma
    A L Jacobs
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Endocrinology 135:1807-15. 1994
    ..In addition, the expression of PGHS-2 by USC in vivo during the periimplantation period may support PG secretion required during early stages of embryo implantation...
  98. ncbi Nitric oxide synthase-cyclooxygenase interactions are involved in tumor cell angiogenesis and migration
    L Davel
    Instituto de Oncologia Angel H Roffo, Departamento de Immunobiologia, Universidad de Buenos Aires, Argentina
    J Biol Regul Homeost Agents 16:181-9. 2002
    ..We also provide evidence of a positive regulatory effect of protein tyrosine kinases on NOS as well as on COX enzymatic functions affecting tumor induced angiogenesis and cell migration...
  99. ncbi p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: implications for the actin cytoskeleton
    Louis C Martineau
    Ottawa Health Research Institute, Division of Nephrology, Ottawa Hospital and Univ of Ottawa, 451 Smyth Rd, Rm 1317, Ottawa, Ontario, Canada K1H 8M5
    Am J Physiol Renal Physiol 286:F693-701. 2004
    ..Enhanced EP4 receptor signaling may undermine podocyte cytoskeletal dynamics and thereby compromise filtration barrier function under conditions of increased Pgc...
  100. pmc Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice
    Jeff Reese
    Department of Pediatrics, Vanderbilt University Medical Center, 1125 MRB IV Bldg, 2215 B Garland Avenue, Nashville, TN 37232 0656, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1717-1723. 2006
    ..They are consistent with a novel role for prostaglandins in ductus arteriosus contractile development...
  101. ncbi Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:1498-506. 2007
    ..These mice will provide a valuable reagent with which to elucidate the distinct roles of the COX enzymes in mammalian biology...

Research Grants21

  1. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  2. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  3. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  4. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  5. Regulation of Transepithelial Transport in PKD
    Rajeev Rohatgi; Fiscal Year: 2008
    ..SA II: To identify those factors that regulate the avid Na absorption seen in ARPKD cyst lining epithelial cells. ..
  6. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..It is intended that this program will enable several laboratories to work individually and together to achieve the highest degree of innovating and productivity. ..
  7. Aspirin for Breast Cancer Prevention
    LOUISE HOWE; Fiscal Year: 2006
    ..In particular, we will establish whether aspirin has comparable or greater efficacy than the selective cyclooxygenase 2 (COX-2) inhibitor celecoxib...
  8. Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity
    Chu Chen; Fiscal Year: 2010
    ..The outcome from the proposed project will also provide new targets for designing drugs aimed at treating or alleviating COX-2-mediated degenerative diseases. ..
  9. Mechanisms of Ductus Arteriosus Regulation
    JOHN JEFFREY REESE; Fiscal Year: 2010
    ..These studies will examine new roles for prostaglandins and their relationship with other vasoactive mediators during development. ..
  10. Corticotropin Releasing Factor-Norepinephrine Interactions in Stress & Depression
    ADRIAN DUNN; Fiscal Year: 2008
    ..The results should establish a model and indicate the nature of the cerebral structures involved, so that we can subsequently test the feed-forward hypothesis [unreadable] [unreadable]..
  11. Role of COX2 in Medullary Interstitial Cell Survival and Function
    Gilbert Moeckel; Fiscal Year: 2008
    ..role of Src family kinases (SFKs) on hypertonicity-induced signaling that mediates increased prostanoid synthesis (COX2) and osmolyte accumulation (TonEBP/NFAT5) (specific aim 2)...
  12. Rho-Dependent COX-2 Expression in Intestinal Cells
    Lee Slice; Fiscal Year: 2007
    ..3) Define the role of Rho and of Protein Kinases acting upstream and downstream of Rho in COX-2 expression in intestinal epithelial cells. 4) Characterize COX-2 promoter elements that are responsive to Rho. ..
  13. Role of Organic Osmolytes in Renal Papillary Necrosis
    Gilbert Moeckel; Fiscal Year: 2007
    ..We hypothesize that COX2 inhibitors (i.e...
  14. Endothelial Deformation and Coronary Arteriolar Function
    Dong Sun; Fiscal Year: 2006
    ....
  15. Counterblance in Inflammation
    MARION CHAN; Fiscal Year: 2005
    ..If feedback mechanisms become a new focus then a groundbreaking paradigm shift would have been made for the development of treatment for arthritis and other inflammation-induced tissue damages. ..
  16. Th1-to Th2 shift of HSP65 responses and atherogenesis
    Yoshimi Shibata; Fiscal Year: 2005
    ..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
  17. Visualizing COX-2 in kidney function and development
    Victoria Norwood; Fiscal Year: 2005
    ..This proposal will therefore answer vital, basic, currently inaccessible, questions about the biology of COX-2, eicosanoid pathways in the kidney, and the mechanisms by which COX-2 regulates renal development. ..
  18. PROSTAGLANDIN SIGNALING IN FEMALE REPRODUCTION
    John Reese; Fiscal Year: 2005
    ..The results of these experiments will enhance the understanding of maternal-fetal PG signaling, and are likely to provide new insights into premature or dysfunctional labor in women. ..
  19. Combination Chemoprevention of ER-Negative Breast Cancer
    LOUISE HOWE; Fiscal Year: 2004
    ..The results of this study will provide the basis for evaluating this combination approach in women at high risk for breast cancer. ..
  20. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2004
    ..Presently, only limited studies addressing this area have been performed. Our proposal fills this gap of knowledge. ..
  21. Arachidonic Acid Metabolism in Blood and Vascular Cells
    Jun Yang Liou; Fiscal Year: 2006
    ..Information provided by studies from this renewal application will have great impact on understanding the fundamental cytoprotection process and offer an excellent opportunity for developing new therapeutic agents. ..