Cxcl12

Summary

Gene Symbol: Cxcl12
Description: chemokine (C-X-C motif) ligand 12
Alias: Pbsf, Scyb12, Sdf1, Tlsf, Tpar1, stromal cell-derived factor 1, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, pre-B-cell growth-stimulating factor, thymic lymphoma cell-stimulating factor
Species: mouse

Top Publications

  1. ncbi Primordial germ cell migration in the chick and mouse embryo: the role of the chemokine SDF-1/CXCL12
    Jürg Stebler
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Dev Biol 272:351-61. 2004
  2. ncbi Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain
    Gerald A Schwarting
    Shriver Center University of Massachusetts Medical Center, Waltham, Massachusetts 02452, USA
    J Neurosci 26:6834-40. 2006
  3. doi SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis
    Noriyuki Unoki
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 51:3362-71. 2010
  4. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
  5. ncbi Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury
    J Dawn Abbott
    Department of Cardiology, Yale University Medical School, New Haven, Conn, USA
    Circulation 110:3300-5. 2004
  6. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
  7. ncbi Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice
    Ayelet Dar
    Department of Immunology, Weizmann Institute, Rehovot, Israel
    Exp Hematol 34:967-75. 2006
  8. ncbi Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
    K E McGrath
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, Rochester, New York, 14642, USA
    Dev Biol 213:442-56. 1999
  9. ncbi Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury
    Florian Tögel
    Department of Medicine, Division of Nephrology, University of Utah and VA Medical Centers, Salt Lake City, Utah 84148, USA
    Kidney Int 67:1772-84. 2005
  10. doi Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes
    S G Sayyed
    Nephrological Center, Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
    Diabetologia 52:2445-54. 2009

Detail Information

Publications165 found, 100 shown here

  1. ncbi Primordial germ cell migration in the chick and mouse embryo: the role of the chemokine SDF-1/CXCL12
    Jürg Stebler
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Dev Biol 272:351-61. 2004
    ..migration in these species, we have investigated the role of the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) in guiding the cells towards their target in the chick embryo...
  2. ncbi Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain
    Gerald A Schwarting
    Shriver Center University of Massachusetts Medical Center, Waltham, Massachusetts 02452, USA
    J Neurosci 26:6834-40. 2006
    ..We show here that stromal cell-derived factor-1 [SDF-1, also known as chemokine C-X-C motif ligand 12 (CXCL12)] is expressed in the embryonic nasal mesenchyme from as early as E10 in an increasing rostral to caudal gradient ..
  3. doi SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis
    Noriyuki Unoki
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 51:3362-71. 2010
    ..CONCLUSIONS. SDF-1/CXCR4 promotes retinal angiogenesis by both tip cell activation and the indirect angiogenic effects of microglia...
  4. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..These results may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia...
  5. ncbi Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury
    J Dawn Abbott
    Department of Cardiology, Yale University Medical School, New Haven, Conn, USA
    Circulation 110:3300-5. 2004
    ..The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell-derived factor-1alpha (SDF-1) in this process...
  6. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  7. ncbi Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice
    Ayelet Dar
    Department of Immunology, Weizmann Institute, Rehovot, Israel
    Exp Hematol 34:967-75. 2006
    The chemokine SDF-1 (CXCL12) and its receptor CXCR4 are involved in regulation of migration, survival, and development of multiple cell types, including human hematopoietic CD34+/CD38-/low and stromal STRO-1+ stem cells...
  8. ncbi Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
    K E McGrath
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, Rochester, New York, 14642, USA
    Dev Biol 213:442-56. 1999
    ..Migration occurred with an optimum dose similar to that found for adult hematopoietic cells and was dependent on the presence of SDF-1 in a gradient. This work suggests roles for chemokine signaling in multiple embryogenic events...
  9. ncbi Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury
    Florian Tögel
    Department of Medicine, Division of Nephrology, University of Utah and VA Medical Centers, Salt Lake City, Utah 84148, USA
    Kidney Int 67:1772-84. 2005
    ..The postischemic kidney has been shown to recruit different leukocyte populations, including bone marrow-derived stem cells. Therefore, we investigated the SDF-1/CXCR4 system in the kidney after ischemic acute renal failure (ARF)...
  10. doi Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes
    S G Sayyed
    Nephrological Center, Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
    Diabetologia 52:2445-54. 2009
    Chemokine (C-X-C motif) ligand 12 (CXCL12) (also known as stromal cell-derived factor-1 [SDF-1]-alpha) is a homeostatic chemokine with multiple roles in cell homing, tumour metastasis, angiogenesis and tissue regeneration after acute ..
  11. doi Pathways implicated in stem cell migration: the SDF-1/CXCR4 axis
    Yaron Vagima
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Methods Mol Biol 750:277-89. 2011
    ..Stromal Derived Factor-1 (SDF-1, CXCL12) and its major receptor CXCR4 play major roles in stem cell motility and development...
  12. doi Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model
    Shu Chi Wang
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    Lab Invest 92:151-62. 2012
    ..More importantly, ALTS1C1 expressed a relatively high level of stromal-derived factor-1 (SDF-1/CXCL12) in vitro and in vivo and higher microvascular density (MVD) in vivo...
  13. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
    ..Stx also enhanced the association of CXCR4, CXCR7, and SDF1 mRNAs with ribosomes...
  14. ncbi Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury
    Magda Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202 3270, USA
    Blood Cells Mol Dis 32:52-7. 2004
    ....
  15. pmc Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2)
    Z Liu
    Thier 306, Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Diabetologia 52:1589-98. 2009
    ..Since AKT is known to modulate the wingless-type MMTV integration site family (WNT) signalling cascade, we examined the effects of SDF-1/CXCR4 on WNT signalling in beta cells and whether this signalling is important for cell survival...
  16. pmc Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
    Anne Christine Hick
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    BMC Dev Biol 9:66. 2009
    ..The morphogenic mechanisms by which the ductal network is established as well as the signaling pathways involved in this process are poorly understood...
  17. pmc Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man
    Andrew J Boyle
    Department of Medicine, Division of Cardiology, University of California San Francisco, USA
    J Transl Med 9:150. 2011
    ..It remains unknown if they are produced by, and released from, the heart in order to attract stem cells to repair the damaged myocardium...
  18. ncbi Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury
    Joseph M Petty
    Department of Medicine, University of Vermont College of Medicine, 149 Beaumont Avenue, Burlington, VT 05405, USA
    J Immunol 178:8148-57. 2007
    ..described chemoattractant effects on marrow neutrophils, we investigated whether stromal-derived factor-1 (SDF-1) (CXCL12) might participate in this later phase of recruitment...
  19. pmc Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis
    Kevin S Carbajal
    Department of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, and Institute for Immunology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 107:11068-73. 2010
    ..Treatment with anti-CXCL12 [stromal derived factor-1alpha, (SDF-1alpha)] blocking serum resulted in a marked impairment in migration and ..
  20. ncbi SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs
    L Carramolino
    Pharmacia and Upjohn, R and D, Madrid, Spain
    Gene 195:151-9. 1997
    ..The SA-1 gene described in this study is highly conserved between mouse and man. This implies a crucial function for this protein...
  21. pmc HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta
    Hui Peng
    Laboratory of Neurotoxicology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68195 5880, USA
    Glia 54:619-29. 2006
    ....
  22. ncbi Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Eberhard Karls Universitätsklinikum Tübingen, Tubingen, Germany
    Circulation 117:206-15. 2008
    ..The chemokine stromal cell-derived factor-1 (SDF-1) regulates homing of CD34+ stem cells. We evaluated the role of platelet-derived SDF-1 in adhesion and differentiation of human CD34+ cells into endothelial progenitor cells...
  23. doi Bone marrow AT1 augments neointima formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1{alpha}
    Hirokazu Yokoi
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566 Japan
    Arterioscler Thromb Vasc Biol 30:60-7. 2010
    ....
  24. pmc Inhibition of stromal cell-derived factor-1α further impairs diabetic wound healing
    Dustin M Bermudez
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Vasc Surg 53:774-84. 2011
    ..We hypothesized that SDF-1α is a critical component of the normal wound-healing response and that inhibition of SDF-1α would further delay the wound-healing process...
  25. pmc SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation
    Raphael A Nemenoff
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Arterioscler Thromb Vasc Biol 31:1300-8. 2011
    ..We investigated the effects of SDF-1α on resident SMC and bone marrow-derived cells and in mediating neointima formation...
  26. pmc Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
    Ki Woo Kim
    Division of Hypothalamic Research and Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:10673-8. 2011
    ..Collectively, these results indicate that SF-1 directs transcriptional programs in the hypothalamus relevant to coordinated control of energy homeostasis, especially after excess caloric intake...
  27. doi MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia
    Coen van Solingen
    Department of Nephrology, LUMC, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Cardiovasc Res 92:449-55. 2011
    ..Based on the seed sequence, miR-126 can also be predicted to regulate vasculogenesis by modulating the endothelial expression of stromal cell-derived factor-1 (SDF-1)...
  28. pmc Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendriti
    Cristina Delgado-Martín
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
    J Biol Chem 286:37222-36. 2011
    ..As maDCs are exposed to chemokine CXCL12 (receptors CXCR4 and CXCR7) during their migration, its functions are amenable to be regulated by this ligand...
  29. pmc Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord
    Haoqian Zhang
    Department of Neurosurgery, University of California, San Francisco, California 94143 0110, USA
    J Neurosci 31:15894-903. 2011
    ..cord involve cooperativity between the upregulation of the chemoattractant stromal cell-derived factor-1 (SDF-1)/CXCL12 in the injured cord and matrix metalloproteinase-9 (MMP-9/gelatinase B), expressed by infiltrating monocytes...
  30. pmc Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger
    Gerard J Madlambayan
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida, Gainesville, Florida, USA
    Blood 114:4310-9. 2009
    ..The varied BM contribution seen in different model systems is suggestive of redundant mechanisms governing postnatal neovasculogenesis and provides an explanation for contradictory results observed in the field...
  31. pmc Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure
    Shi Zhu Jin
    Department of Gastroenterology, First Clinical College, Jilin University, Norman Bethune School of Medicine, Changchun 130021, Jilin Province, China
    World J Gastroenterol 15:2657-64. 2009
    ..To evaluate the number of bone marrow mononuclear cells (BMMC) that are migrated to the liver following transplantation of murine BMMC into mice with acute liver injury...
  32. ncbi Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells
    Ayelet Dar
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 6:1038-46. 2005
    Regulation of the availability of chemokine SDF-1 (CXCL12) in bone marrow is still not fully understood...
  33. ncbi CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis
    Erin E McCandless
    Division of Infectious Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:8053-64. 2006
    ..The molecular mechanisms that orchestrate this movement are not known. The chemokine CXCL12 is highly expressed throughout the CNS by microendothelial cells under normal conditions, suggesting it might play ..
  34. pmc A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
    C C Bleul
    The Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, Massachusetts 02115, USA
    J Exp Med 184:1101-9. 1996
    ..Since SDF-1 is expressed constitutively in a broad range of tissues it may have a role in immune surveillance and in basal extravasation of lymphocytes and monocytes rather than in inflammation...
  35. ncbi The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
    K Tachibana
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Japan
    Nature 393:591-4. 1998
    ..The cell-surface receptor CXCR4 is a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1 (for pre-B-cell growth-stimulating factor/stromal-cell-derived factor), which is responsible for B-cell ..
  36. ncbi A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells
    Wei Zhu
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 282:18676-85. 2007
    ..Our data provide the first evidence for a co-requirement of the SDF-1/CXCR4 signaling axis in BMP2-induced osteogenic differentiation of C2C12 and ST2 cells and, thus, uncover a new potential target for modulation of osteogenesis...
  37. pmc Nitric oxide donor upregulation of stromal cell-derived factor-1/chemokine (CXC motif) receptor 4 enhances bone marrow stromal cell migration into ischemic brain after stroke
    Xu Cui
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    Stem Cells 25:2777-85. 2007
    Stromal cell-derived factor-1 (SDF1) and its chemokine (CXC motif) receptor 4 (CXCR4), along with matrix metalloproteinases (MMPs), regulate bone marrow stromal cell (BMSC) migration...
  38. pmc Cardiogenic induction of pluripotent stem cells streamlined through a conserved SDF-1/VEGF/BMP2 integrated network
    Anca Chiriac
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e9943. 2010
    ..As embryonic stem cells respond concomitantly to diverse signaling pathways during differentiation, extraction of a pro-cardiogenic network would offer a roadmap to streamline cardiac progenitor output...
  39. ncbi Caveolin plays a central role in endothelial progenitor cell mobilization and homing in SDF-1-driven postischemic vasculogenesis
    Elhem Sbaa
    Unit of Pharmacology and Therapeutics, University of Louvain Medical School, Brussels, Belgium
    Circ Res 98:1219-27. 2006
    ..In particular, a transient reduction in caveolin expression was shown to therapeutically increase the engraftment of progenitor cells...
  40. pmc p21Cip1 modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice
    Michelle Olive
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland 20817, USA
    J Clin Invest 118:2050-61. 2008
    ....
  41. doi Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors
    Roberta Melchionna
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Via Monti di Creta 104, Rome 00167, Italy
    Muscle Nerve 41:828-35. 2010
    ..Our experiments demonstrate that SDF-1 regulates myogenic differentiation via both CXCR4 and CXCR7 chemokine receptors...
  42. pmc Stromal-derived factor-1 and its receptor, CXCR4, are constitutively expressed by mouse liver sinusoidal endothelial cells: implications for the regulation of hematopoietic cell migration to the liver during extramedullary hematopoiesis
    Mayela Mendt
    Unidad de Terapia Celular Laboratorio de Patología Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado, Caracas, Venezuela
    Stem Cells Dev 21:2142-51. 2012
    ..To our knowledge, this is the first report showing that LSEC not only express and secrete SDF-1, but also its receptor CXCR4...
  43. pmc Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy
    Koichi Murata
    Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan
    PLoS ONE 7:e37163. 2012
    Stromal cell-derived factor 1 (SDF-1/CXCL12/PBSF) plays important roles in the biological and physiological functions of haematopoietic and mesenchymal stem cells...
  44. pmc Hypoxic preconditioning improves survival of cardiac progenitor cells: role of stromal cell derived factor-1α-CXCR4 axis
    Fengdi Yan
    Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China
    PLoS ONE 7:e37948. 2012
    ....
  45. pmc Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo
    Claudia Orelio
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 112:4895-904. 2008
    ..Our results suggest that IL-1 is an important homeostatic regulator at the earliest time of HSC development, acting to limit the differentiation of some HSCs along the myeloid lineage...
  46. pmc Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 186:121-31. 2011
    Antagonism of CXCR4 disrupts the interaction between the CXCR4 receptor on hematopoietic stem cells (HSCs) and the CXCL12 expressed by stromal cells in the bone marrow, which subsequently results in the shedding of HSCs to the periphery...
  47. pmc The chemokine stromal cell-derived factor-1 regulates GABAergic inputs to neural progenitors in the postnatal dentate gyrus
    Bula J Bhattacharyya
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:6720-30. 2008
    ..Hence, SDF-1/CXCR4 signaling is likely to be an important regulator of adult neurogenesis in the DG...
  48. ncbi Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins
    K Tashiro
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Science 261:600-3. 1993
    ..Two cDNAs that encoded putative cytokine molecules, stromal cell-derived factor-1 alpha (SDF-1 alpha) and SDF-1 beta, which belong to the intercrine-macrophage inflammatory protein superfamily, were cloned...
  49. ncbi Interleukin-6 and cAMP induce stromal cell-derived factor-1 chemotaxis in astroglia by up-regulating CXCR4 cell surface expression. Implications for brain inflammation
    Veysel Odemis
    Abteilung Anatomie und Zellbiologie, Universitat Ulm, 89069 Ulm, Germany
    J Biol Chem 277:39801-8. 2002
    ....
  50. ncbi Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an alternative hypothesis to stem cell plasticity
    Anna Pituch-Noworolska
    Polish American Children s Hospital, Medical College, Jagiellonian University, Cracow, Poland
    Folia Histochem Cytobiol 41:13-21. 2003
    ....
  51. ncbi A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo
    Toshiaki Ara
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Osaka, Japan
    J Immunol 170:4649-55. 2003
    ..In CXCL12(-/-) or CXCR4(-/-) embryos on a C57BL/6 background, accumulation of T cell progenitors in the outer mesenchymal ..
  52. ncbi Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis
    Benjamin T Suratt
    University of Vermont College of Medicine, 149 Beaumont Ave, Burlington, VT 05405, USA
    Blood 104:565-71. 2004
    ....
  53. ncbi Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 118:1981-9. 2005
    ....
  54. ncbi Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stem Cells Dev 14:199-203. 2005
    ..Here we demonstrate that stromal cell-derived factor-1 (SDF-1/CXCL12), known for its ability to attract and to promote survival of hematopoietic progenitor cells (HPCs) and stem cells,..
  55. ncbi Complement C3a enhances CXCL12 (SDF-1)-mediated chemotaxis of bone marrow hematopoietic cells independently of C3a receptor
    Marek Honczarenko
    Joint Program in Transfusion Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 175:3698-706. 2005
    Complement C3a promotes CXCL12-induced migration and engraftment of human and murine hemopoietic progenitor cells, suggesting a cross-influence between anaphylatoxin and chemokine axes...
  56. ncbi The SDF-1/CXCR4 pathway and the development of the cerebellar system
    Tim O Vilz
    Anatomisches Institut, Anatomie und Zellbiologie, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Eur J Neurosci 22:1831-9. 2005
    ..Moreover, they fail to express plexin D1, suggesting that SDF-1/CXCR4 signalling may also impinge on axon guidance critical to the orderly formation of granule cell mossy fibre afferents...
  57. pmc Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
    David K Jin
    Department of Genetic Medicine, Division of Hematology Medical Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 12:557-67. 2006
    ..Delivery of SDF-1 may be effective in restoring angiogenesis in individuals with vasculopathies...
  58. pmc Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism
    Jessy Deshane
    Department of Medicine, Nephrology Research and Training Center and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 204:605-18. 2007
    ..These findings demonstrate a mechanistic role for HO-1 in SDF-1-mediated angiogenesis and provide new avenues for therapeutic approaches in vascular repair...
  59. ncbi AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis
    Hal E Broxmeyer
    Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann N Y Acad Sci 1106:1-19. 2007
    The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) and its receptor, CXCR4, are involved in a number of facets of the regulation of hematopoiesis at the level of hematopoietic stem (HSCs) and progenitor (HPCs) cells...
  60. ncbi Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt
    Tatsuya Yano
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 56:2946-57. 2007
    ..We determined whether stromal cell-derived factor (SDF)-1/CXCL12 and its receptor, CX chemokine receptor (CXCR)4, are important for the survival of beta-cells.
  61. doi Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1
    Heng Huei Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, ROC
    J Mol Cell Cardiol 45:44-55. 2008
    ..These data suggest that cardiac HO-1 gene transfer post MI provides protection at least in part by promoting neovascularization through inducing angiogenic factors and the recruitment of circulating progenitor/stem cells...
  62. pmc The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins
    Patricia Rueda
    Departamento de Biologia Experimental, Universidad de Jaen, Jaen, Spain
    PLoS ONE 3:e2543. 2008
    The CXCL12gamma chemokine arises by alternative splicing from Cxcl12, an essential gene during development. This protein binds CXCR4 and displays an exceptional degree of conservation (99%) in mammals...
  63. doi Erythropoietin administration after myocardial infarction in mice attenuates ischemic cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4/SDF-1 axis
    Stefan Brunner
    Klinikum Grosshadern, Medical Department I, Munich, Germany
    FASEB J 23:351-61. 2009
    ..However, EPO has no beneficial effects on resident CSCs. Therefore, new treatment regimes using EPO together with other agents may combine complementary beneficial effects preventing ischemic cardiomyopathy...
  64. pmc Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow
    Joseph M Petty
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Immunol 182:604-12. 2009
    ..Furthermore, SDF-1 (CXCL12) signaling through neutrophil CXCR4 augments VLA-4 adhesion to VCAM-1 in vitro, an effect that is blocked by ..
  65. doi SDF-1 alpha expression during wound healing in the aged is HIF dependent
    Shang A Loh
    Department of Surgery, Division of Plastic Surgery, 257 Campus Drive, GK 201, Stanford, CA 94305 5148, USA
    Plast Reconstr Surg 123:65S-75S. 2009
    ..Thus, the authors examined the relative importance of interleukin (IL)-1 beta and hypoxia-inducible factor (HIF)-1 alpha on SDF-1 alpha expression in aged wound healing...
  66. pmc Stromal cell-derived factor-1/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1+CD11b+ cells
    Bob Y Liu
    Research Oncology, Genentech Inc, South San Francisco, California, USA
    PLoS ONE 5:e8611. 2010
    ..However, these differences have not been formally described, nor have any angiogenic factors been implicated to be involved in the Wnt1 tumors...
  67. ncbi Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene
    M Shirozu
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Genomics 28:495-500. 1995
    ..cDNA and genomic clones of human SDF1 alpha and SDF1 beta (SDF1A and SDF1B) were isolated and characterized...
  68. pmc Molecular cloning and structure of a pre-B-cell growth-stimulating factor
    T Nagasawa
    Division of Immunology, Osaka University, Japan
    Proc Natl Acad Sci U S A 91:2305-9. 1994
    ..The amino acid sequence of this cytokine, designated pre-B-cell growth-stimulating factor (PBSF), revealed that it is a member of intercrine alpha subfamily...
  69. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..Pre-B-cell growth-stimulating factor/stromal cell-derived factor-1 (PBSF/SDF-1) is a member of the CXC group of chemokines PBSF/SDF-1 stimulates proliferation of B-cell progenitors in ..
  70. pmc Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin
    T Nagasawa
    Department of Immunology, Osaka Medical Center for Maternal and Child Health, Japan
    Proc Natl Acad Sci U S A 93:14726-9. 1996
    Pre-B-cell growth-stimulating factor/ stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell-derived factor and as a pre-B-cell stimulatory factor...
  71. pmc Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
    Q Ma
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:9448-53. 1998
    ..This receptor-ligand selectivity is unusual among chemokines and their receptors, as is the function in migration of nonhematopoietic cells...
  72. pmc Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor
    Meiling Lu
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 99:7090-5. 2002
    ..Finally, the DG is unusual as a site of adult neurogenesis. We find that both CXCR4 and SDF-1 are expressed in the adult DG, suggesting an ongoing role in DG morphogenesis...
  73. ncbi The chemokine SDF1 regulates migration of dentate granule cells
    Anil Bagri
    Neurodevelopmental Disorders Laboratory, Department of Neurology, Program in Neuroscience, University of California, San Francisco, CA 94143 0435, USA
    Development 129:4249-60. 2002
    ..In searching for candidate ligands that may regulate dentate granule cell migration, we found that SDF1, a chemokine that regulates cerebellar and leukocyte migration, and its receptor CXCR4 are expressed in patterns ..
  74. ncbi Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo
    Hal E Broxmeyer
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 170:421-9. 2003
    ..To further evaluate SDF-1/CXCL12 effects on progenitor cell survival, transgenic mice endogenously expressing SDF-1/CXCL12 under a Rous sarcoma ..
  75. ncbi Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus
    Karl Balabanian
    Institut National de la Santé et de la Recherche Médicale Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 170:3392-400. 2003
    In normal mice, stromal cell-derived factor 1 (SDF-1/CXCL12) promotes the migration, proliferation, and survival of peritoneal B1a (PerB1a) lymphocytes...
  76. pmc Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)
    Toshiaki Ara
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 100:5319-23. 2003
    ..Stromal cell-derived factor-1 (SDF-1, also called PBSF and CXCL12) is a member of chemokines, a family of structurally related chemoattractive cytokines...
  77. ncbi The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells
    Sreekanth H Chalasani
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 23:4601-12. 2003
    ..Mouse embryos lacking the CXCR4 receptor have a reduced number of retinal ganglion cells. The ligand of CXCR4, SDF-1, may therefore provide generalized trophic support to neurons during their development and maturation...
  78. ncbi CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development...
  79. ncbi The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival
    Kathleen A Molyneaux
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 130:4279-86. 2003
    ..Recent genetic evidence in zebrafish has shown that the interaction between stromal cell-derived factor 1 (SDF1) and its G-protein-coupled receptor CXCR4, already known to control many types of normal and pathological cell ..
  80. pmc The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas
    Ayse G Kayali
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 163:859-69. 2003
    ..Together, these data indicate that the SDF-1alpha-CXCR4 ligand receptor axis is an obligatory component in the maintenance of duct cell survival, proliferation, and migration during pancreatic regeneration...
  81. pmc Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression
    Yoshihiro Ueda
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 199:47-58. 2004
    ..Mobilization reflects a reduced CXCL12 message and protein in BM and changes to the BM environment that prevents homing by cells from naive donors...
  82. ncbi Expression of the chemokine receptor Cxcr4 mRNA during mouse brain development
    Fadel Tissir
    Developmental Genetics Unit, University of Louvain Medical School, avenue E Mounier, 73 Box DENE 7382, B1200 Brussels, Belgium
    Brain Res Dev Brain Res 149:63-71. 2004
    The expression of Cxcr4 mRNA that encodes the receptor for the chemokine Sdf1 was studied during mouse brain development using in situ hybridization, from E9.5 to maturity at P21...
  83. ncbi SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
    Elena De Falco
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Blood 104:3472-82. 2004
    ..Our findings unravel a function for SDF-1 in increase of EPC number and formation of vascular structures by bone marrow progenitor cells...
  84. ncbi Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 5:943-52. 2004
    ..Centroblasts had high expression of CXCR4 and GC B cells migrated toward the CXCR4 ligand SDF-1 (CXCL12), which was more abundant in the dark zone than in the light zone...
  85. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
    ..CXCR4 expression within germinal zones suggests that NSC homing after injury and migration during development may invoke similar mechanisms...
  86. pmc SDF-1 is both necessary and sufficient to promote proliferative retinopathy
    Jason M Butler
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, Florida, USA
    J Clin Invest 115:86-93. 2005
    ..Together, these data demonstrate that SDF-1 plays a major role in proliferative retinopathy and may be an ideal target for the prevention of proliferative retinopathy...
  87. ncbi Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo
    Yan Xi Sun
    Department of Periodontics, Prevention, Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    J Bone Miner Res 20:318-29. 2005
    ..Neutralization of CXCR4 limited the number and the growth of intraosseous metastasis in vivo. Together, these in vivo metastasis data provide critical support that SDF-1/CXCR4 plays a role in skeletal metastasis...
  88. ncbi A role for CXCR4 signaling in survival and migration of neural and oligodendrocyte precursors
    M Dziembowska
    Department of Neuroscience, Pasteur Institute, Paris, France
    Glia 50:258-69. 2005
    ..The present study shows that signaling of CXCR4 receptor by the chemokine CXCL12 regulates survival and migration of neural precursors (NP) as well as oligodendrocyte progenitors (OP)...
  89. ncbi Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts
    Lorinda M Wright
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Bone 36:840-53. 2005
    ..Stromal cell-derived factor-1 (SDF-1 or CXCL12) is a chemokine highly expressed by bone endothelium, BMSC, and immature Ob that is essential for the normal ..
  90. pmc G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
    Craig L Semerad
    Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110, USA
    Blood 106:3020-7. 2005
    Accumulating evidence indicates that interaction of stromal cell-derived factor 1 (SDF-1/CXCL12 [CXC motif, ligand 12]) with its cognate receptor, CXCR4 (CXC motif, receptor 4), generates signals that regulate hematopoietic progenitor ..
  91. pmc CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells
    Elena Vasyutina
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Genes Dev 19:2187-98. 2005
    ..We show here that migrating muscle progenitors express the chemokine receptor CXCR4. The corresponding ligand, SDF1, is expressed in limb and branchial arch mesenchyme; i.e...
  92. ncbi Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling
    Victor Borrell
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nat Neurosci 9:1284-93. 2006
    ..We also show that the chemokine CXCL12 secreted by the meninges enhances the dispersion of Cajal-Retzius cells along the cortical surface, while ..
  93. ncbi Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    Tatsuki Sugiyama
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 25:977-88. 2006
    ..Most HSCs were found in contact with the cells expressing high amounts of CXCL12, which we have called CXCL12-abundant reticular (CAR) cells...
  94. ncbi Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone
    Marie Catherine Tiveron
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
    J Neurosci 26:13273-8. 2006
    ..We show here that the chemokine stromal-derived factor 1 (SDF-1; CXCL12) is expressed in the main invasion route for cortical interneurons in the SVZ/IZ...
  95. pmc The CXCR4/CXCL12 (SDF-1) signalling pathway protects non-obese diabetic mouse from autoimmune diabetes
    E Aboumrad
    INSERM 449, Faculte Laennec, Lyon, France
    Clin Exp Immunol 148:432-9. 2007
    ..Immunofluorescence studies indicated that AMD3100 reduced the number of CXCR4(+) and SDF-1 positive cells in the inflamed islets. We can conclude that the CXCL-12/CXCR4 pathway has protective effects against autoimmune diabetes...
  96. pmc Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha
    Katherine A Gallagher
    Department of Surgery, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Invest 117:1249-59. 2007
    ..The targets identified, which we believe to be novel, can significantly advance the field of diabetic wound healing...
  97. pmc Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis
    Xiaofeng Hu
    Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40202, USA
    Circulation 116:654-63. 2007
    ..However, the role of the SDF-1alpha-CXCR4 axis in modulating myocardial ischemia/reperfusion injury is unknown...
  98. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
    ..We confirmed that the principal chemokine ligand for CXCR7 was CXCL12/SDF-1, which also binds CXCR4...
  99. pmc The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4
    Cedric Laguri
    Institut de Biologie Structurale, UMR 5075 CNRS CEA UJF, Grenoble, France
    PLoS ONE 2:e1110. 2007
    ..The alternative splicing of the cxcl12 gene generates a recently identified isoform, CXCL12gamma, which structure/function relationships remain ..
  100. pmc Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling
    Guangnan Li
    Program in Neuroscience, and Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:1085-98. 2008
    ..We show that a chemokine, Cxcl12, is an attractant for interneurons during the stage of stream formation and tangential migration...
  101. doi Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model
    Toshiyuki Kitaori
    Kyoto University, Kyoto, Japan
    Arthritis Rheum 60:813-23. 2009
    Stromal cell-derived factor 1 (SDF-1; CXCL12/pre-B cell growth-stimulating factor) is a dominant chemokine in bone marrow and is known to be involved in inflammatory diseases, including rheumatoid arthritis...

Research Grants14

  1. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..We hypothesized that the CXC chemokine Stromal cell derived factor-1 (SDF-l/CXCL12) and its receptor CXCR4 are involved in these important and clinically relevant processes...
  2. GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATION
    Thalia Papayannopoulou; Fiscal Year: 2002
    ....
  3. NEUTROPHIL HOMEOSTASIS IN LUNG INFLAMMATION
    BENJAMIN SURATT; Fiscal Year: 2005
    ..These studies will address fundamental questions of neutrophil biology as well as provide clues to the mechanisms of lung injury in bone marrow transplantation. ..
  4. IL-6 regulation of matrix degradation in liver fibrosis
    Meena Bansal; Fiscal Year: 2006
    ..Understanding these mechanisms will provide the basis for the development of novel anti-fibrotic therapies to treat a widely prevalent disease for which there is no effective treatment to date. ..
  5. Imaging Vaccina Viral-Host Pathogenesis
    Gary Luker; Fiscal Year: 2007
    ..Collectively, the research is expected to facilitate the development of improved vaccines and treatments for smallpox, thereby enhancing our ability to prevent the use of smallpox for bioterrorism. [unreadable] [unreadable] [unreadable]..
  6. Lymphocyte Exit from Tissues: Control and Significance to Host Defense
    GUDRUN DEBES; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Role of Matrix Metalloproteinase-2 in Liver Fibrosis
    Meena Bansal; Fiscal Year: 2007
    ..Findings from these investigations may lead to novel approaches to the treatment of chronic fibrosing liver disease. [unreadable] [unreadable]..
  8. BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLS
    Thalia Papayannopoulou; Fiscal Year: 2009
    ..We believe that the proposed studies will enhance our understanding and provide a more comprehensive picture of the influence of <x4 integrins on prenatal and postnatal hematopoiesis. ..
  9. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  10. Reciprocal regulation of SDF-1 between marrow and lung during acute lung injury
    Benjamin T Suratt; Fiscal Year: 2010
    ..The studies we propose are expected to improve our limited understanding of this phase of ALI, and could eventually lead to improved therapies for a condition that continues to be all too often fatal. ..
  11. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  12. Attenuation of Radiation-Induced GI Injury by Cultured Myeloid Progenitors
    Julie Christensen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
    ..These studies will lead to an understanding of the complex factors that guide GnRH neurons to their proper destinations in the hypothalamus to control the hypothalamic-pituitary-gonadal axis. ..