Cxadr

Summary

Gene Symbol: Cxadr
Description: coxsackie virus and adenovirus receptor
Alias: 2610206D03Rik, AU016810, AW553441, CAR, MCAR, MCVADR, coxsackievirus and adenovirus receptor homolog
Species: mouse

Top Publications

  1. doi Cardiomyocyte-targeted overexpression of the coxsackie-adenovirus receptor causes a cardiomyopathy in association with beta-catenin signaling
    Laura Caruso
    Cell Biology Program, Research Institute, Division of Infectious Diseases, Hospital for Sick Children, Toronto, Ontario, Canada
    J Mol Cell Cardiol 48:1194-205. 2010
  2. pmc HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
    R P Tomko
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, NY 10016, USA
    Proc Natl Acad Sci U S A 94:3352-6. 1997
  3. pmc Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene
    Ahmad Pazirandeh
    Ludwig Institutet for Cancer Research, Stockholm Branch, Stockholm, Sweden
    PLoS ONE 6:e20203. 2011
  4. pmc The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K
    Petra Verdino
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 329:1210-4. 2010
  5. pmc The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation
    Deborah A Witherden
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 329:1205-10. 2010
  6. doi The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells
    Christopher Patzke
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    J Neurosci 30:2897-910. 2010
  7. pmc Tissue-specific deletion of the coxsackievirus and adenovirus receptor protects mice from virus-induced pancreatitis and myocarditis
    Nicole L Kallewaard
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cell Host Microbe 6:91-8. 2009
  8. pmc The tight junction protein CAR regulates cardiac conduction and cell-cell communication
    Ulrike Lisewski
    Neuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine MDC, 13122 Berlin Buch, Germany
    J Exp Med 205:2369-79. 2008
  9. pmc Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
    Byung Kwan Lim
    Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
    J Clin Invest 118:2758-70. 2008
  10. ncbi Coxsackievirus and adenovirus receptor is up-regulated in migratory germ cells during passage of the blood-testis barrier
    Momina Mirza
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Institutet, Box 240, SE 17177, Stockholm, Sweden
    Endocrinology 148:5459-69. 2007

Research Grants

Scientific Experts

  • Steven Carson
  • N Rubio
  • Jeffrey Bergelson
  • K Sollerbrant
  • L Lenaerts
  • Yu Feng Li
  • C J Cohen
  • Christian A Shaw
  • Momina Mirza
  • Jin Wen Chen
  • Lennart Philipson
  • Sara Salinas
  • Fabien Loustalot
  • Yeong Seok Oh
  • Eric J Kremer
  • Taranum Sultana
  • Myung Chan Gye
  • Michael Gotthardt
  • Stella Yuen
  • Laura Caruso
  • Mary Anne Opavsky
  • Josephine Nalbantoglu
  • Ulrike Lisewski
  • Petra Verdino
  • Deborah A Witherden
  • Yu Shi
  • Kuo Cheng Huang
  • Charleine Zussy
  • Christoph Schell
  • Bjorn E Clausen
  • Armin A Dorner
  • Roos F J Marsman
  • Ying Gao
  • Ralf F Pettersson
  • Elisabeth Raschperger
  • Jung Yen Liu
  • Nadia Houri
  • Giampietro Schiavo
  • Daniel Henaff
  • Robert Fischer
  • Ahmad Pazirandeh
  • Chen Chen
  • Sebastien Bergeron
  • Julie Smith
  • Ian A Wilson
  • Wendy L Havran
  • Christopher Patzke
  • M A Gray
  • Jonas Fuxe
  • Bingning Dong
  • Nicole L Kallewaard
  • Volker Ruppert
  • Byung Kwan Lim
  • Sang Young Han
  • Fritz G Rathjen
  • K Kawabata
  • Manabu Yamashita
  • R P Tomko
  • Katherine J D A Excoffon
  • Giri Venkatraman
  • Damon R Asher
  • Robert W Finberg
  • Michel G Desarménien
  • Monica Di Luca
  • Cyril Bories
  • Seok Hyun Kim
  • Yves De Koninck
  • Yuko Hotta
  • Jorge Valero
  • Nicolas Lonjon
  • Florence Bernex
  • Felix Junyent
  • Neus Bayo-Puxan
  • Joao O Malva
  • Won Heum Nah
  • Fabrizio Gardoni
  • Bomi Choi
  • Andreas Bregenzer
  • Pierre Louis Tharaux
  • Anna Brand
  • Manuel Rogg
  • Martin Helmstädter
  • Florian Grahammer
  • Oliver Kretz
  • Khalad Karram
  • Tobias B Huber
  • Mi Hou
  • Wing Yee Lui
  • Bastian Spallek
  • Nanette H Bishopric

Detail Information

Publications56

  1. doi Cardiomyocyte-targeted overexpression of the coxsackie-adenovirus receptor causes a cardiomyopathy in association with beta-catenin signaling
    Laura Caruso
    Cell Biology Program, Research Institute, Division of Infectious Diseases, Hospital for Sick Children, Toronto, Ontario, Canada
    J Mol Cell Cardiol 48:1194-205. 2010
    ..a binary transgenic mouse enabling cardiac-restricted doxycycline-regulated expression of Flag-tagged murine CAR (mCAR(+)/alpha MtTA(+) mice)...
  2. pmc HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
    R P Tomko
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, NY 10016, USA
    Proc Natl Acad Sci U S A 94:3352-6. 1997
    ..from human and mouse that encode the human CVB and Ad2 and 5 receptor (HCAR) and the mouse CVB Ad2 and 5 receptor (MCAR). Both are 46-kDa glycoproteins whose primary amino acid sequences are highly homologous...
  3. pmc Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene
    Ahmad Pazirandeh
    Ludwig Institutet for Cancer Research, Stockholm Branch, Stockholm, Sweden
    PLoS ONE 6:e20203. 2011
    To determine the normal function of the Coxsackievirus and Adenovirus Receptor (CAR), a protein found in tight junctions and other intercellular complexes, we constructed a mouse line in which the CAR gene could be disrupted at any ..
  4. pmc The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K
    Petra Verdino
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 329:1210-4. 2010
    Coxsackie and adenovirus receptor (CAR) is the primary cellular receptor for group B coxsackieviruses and most adenovirus serotypes and plays a crucial role in adenoviral gene therapy...
  5. pmc The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation
    Deborah A Witherden
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 329:1205-10. 2010
    ..Binding of JAML to its ligand Coxsackie and adenovirus receptor (CAR) provides costimulation leading to cellular proliferation and cytokine and growth factor production...
  6. doi The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells
    Christopher Patzke
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    J Neurosci 30:2897-910. 2010
    The coxsackievirus-adenovirus receptor (CAR) is a member of the Ig superfamily strongly expressed in the developing nervous system...
  7. pmc Tissue-specific deletion of the coxsackievirus and adenovirus receptor protects mice from virus-induced pancreatitis and myocarditis
    Nicole L Kallewaard
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cell Host Microbe 6:91-8. 2009
    ..cells, infection by group B coxsackievirus (CVB) is mediated by the coxsackievirus and adenovirus receptor (CAR), but the importance of this molecule in CVB-induced disease has not been determined...
  8. pmc The tight junction protein CAR regulates cardiac conduction and cell-cell communication
    Ulrike Lisewski
    Neuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine MDC, 13122 Berlin Buch, Germany
    J Exp Med 205:2369-79. 2008
    The Coxsackievirus-adenovirus receptor (CAR) is known for its role in virus uptake and as a protein of the tight junction...
  9. pmc Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
    Byung Kwan Lim
    Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
    J Clin Invest 118:2758-70. 2008
    The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that belongs to the family of adhesion molecules. In the postnatal heart, it is localized predominantly at the intercalated disc, where its function is not known...
  10. ncbi Coxsackievirus and adenovirus receptor is up-regulated in migratory germ cells during passage of the blood-testis barrier
    Momina Mirza
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Institutet, Box 240, SE 17177, Stockholm, Sweden
    Endocrinology 148:5459-69. 2007
    The coxsackievirus and adenovirus receptor (CAR) is a cell adhesion molecule expressed in epithelial tight junctions and other cell-cell contacts...
  11. ncbi Interaction of the Coxsackie and adenovirus receptor (CAR) with the cytoskeleton: binding to actin
    Kuo Cheng Huang
    Department of Neurology and Neurosurgery, McGill University, Montreal, Que, Canada
    FEBS Lett 581:2702-8. 2007
    The Coxsackie and adenovirus receptor (CAR) is a cell adhesion molecule that is highly expressed in the developing brain. CAR is enriched in growth cone particles (GCP) after subcellular fractionation...
  12. pmc Simultaneous dystrophin and dysferlin deficiencies associated with high-level expression of the coxsackie and adenovirus receptor in transgenic mice
    Christian A Shaw
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University Health Center and Meakins Christie Laboratories, 3801 University St, Montreal, Quebec, Canada H3A 2B4
    Am J Pathol 169:2148-60. 2006
    The Coxsackie and adenovirus receptor (CAR), a cell adhesion molecule of the immunoglobulin superfamily, is usually confined to the sarcolemma at the neuromuscular junction in mature skeletal muscle fibers...
  13. ncbi The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis
    Elisabeth Raschperger
    Ludwig Institute for Cancer Research, Nobels v 3, SE 171 77 Stockholm, Sweden
    Exp Cell Res 312:1566-80. 2006
    The coxsackie- and adenovirus receptor (CAR) is a transmembrane protein belonging to the immunoglobulin superfamily...
  14. ncbi Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis
    Momina Mirza
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Institute, PO Box 240, SE 17177 Stockholm, Sweden
    Exp Cell Res 312:817-30. 2006
    The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein important for viral binding to target cells...
  15. ncbi The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain
    T Honda
    Research Laboratory for Molecular Genetics, Niigata University, 1 Asahimachi, Niigata, Japan
    Brain Res Mol Brain Res 77:19-28. 2000
    ..sequence was recently reported, encoding the mouse homologue of the human coxsackievirus and adenovirus receptor (mCAR)...
  16. ncbi Expression of the adenovirus receptor and its interaction with the fiber knob
    R P Tomko
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016, USA
    Exp Cell Res 255:47-55. 2000
    ..In fact a specific antibody interfering with only CVB binding recognizes the IG2 domain in the receptor, suggesting that the CVB interacts with this region or an overlap between the IG1 and the IG2 regions...
  17. pmc Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs
    Christian A Shaw
    Department of Neurology and Neurosurgery, McGill University and Montreal Neurological Institute, Montreal, Canada
    BMC Cell Biol 5:42. 2004
    The Coxsackie and adenovirus receptor (CAR) has a restricted expression pattern in the adult. In skeletal muscle, although CAR is expressed in immature fibers, its transcript levels are barely detectable in mature muscle...
  18. pmc The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 72:415-9. 1998
    Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated...
  19. ncbi The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2)
    Momina Mirza
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Intitutet, Box 240, SE 17177 Stockholm, Sweden
    Exp Cell Res 309:110-20. 2005
    The coxsackievirus and adenovirus receptor (CAR) is a cell surface protein that is proposed to be involved in cell-cell adhesion...
  20. ncbi Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 275:1320-3. 1997
    A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR)...
  21. ncbi Receptor for the group B coxsackieviruses and adenoviruses: CAR
    S D Carson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Rev Med Virol 11:219-26. 2001
    Considerable progress towards the characterisation of the long-sought receptor, CAR (coxsackievirus and adenovirus receptor), shared by group B coxsackieviruses (CVB) and most adenoviruses (Ad) has been made since it was isolated and ..
  22. ncbi The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)
    Kerstin Sollerbrant
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Intitutet, SE 17177 Stockholm, Sweden
    J Biol Chem 278:7439-44. 2003
    The Coxsackievirus and adenovirus receptor (CAR) functions as a virus receptor, but its primary biological function is unknown...
  23. ncbi Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development
    Armin A Dorner
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rössie Strasse10, 13125 Berlin, Germany
    J Cell Sci 118:3509-21. 2005
    The coxsackievirus-adenovirus receptor (CAR) is a cell contact protein on various cell types with unknown physiological function...
  24. ncbi Developmental distribution of coxsackie virus and adenovirus receptor localized in the nervous system
    Yuko Hotta
    Department of Molecular Genetics, Genome Science Branch, Center for Bioresource based Researches, Brain Research Institute, Niigata University, Niigata, Japan
    Brain Res Dev Brain Res 143:1-13. 2003
    Mouse coxsackie virus and adenovirus receptor (mCAR), which was isolated from the nerve growth cone-enriched fraction of newborn mouse brains, is a member of immunoglobulin-super family, and functions as a homophilic adhesion molecule...
  25. ncbi Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves
    Jin Wen Chen
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, USA
    Circ Res 98:923-30. 2006
    The coxsackievirus and adenovirus receptor (CAR), which mediates infection by the viruses most commonly associated with myocarditis, is a transmembrane component of specialized intercellular junctions, including the myocardial ..
  26. ncbi Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development
    Damon R Asher
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Genesis 42:77-85. 2005
    The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that is known to be a site of viral attachment and entry, but its physiologic functions are undefined...
  27. doi Surmounting limited gene delivery into primary immune cell populations: Efficient cell type-specific adenoviral transduction by CAR
    Bjorn E Clausen
    Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    Eur J Immunol 45:1596-9. 2015
    ..leukocytes to adenoviral infection, due to insufficient expression of the human coxsackie/adenovirus receptor (CAR). In this issue of the European Journal of Immunology, Heger et al. [Eur. J. Immunol. 2015...
  28. doi Mice depleted of the coxsackievirus and adenovirus receptor display normal spermatogenesis and an intact blood-testis barrier
    Taranum Sultana
    Paediatric Endocrinology UnitDepartment of Women s and Children s HealthDepartment of Biosciences and NutritionNovumDepartment of Physiology and PharmacologyKarolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden
    Reproduction 147:875-83. 2014
    The coxsackievirus and adenovirus receptor (CXADR (CAR)) is a cell adhesion molecule expressed mainly in epithelial cells...
  29. pmc Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response
    Christoph Schell
    Renal Division, University Medical Center Freiburg, Freiburg, Germany Spemann Graduate School of Biology and Medicine SGBM, Albert Ludwigs University Freiburg, Freiburg, Germany Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg, Germany
    PLoS ONE 10:e0129424. 2015
    The coxsackie- and adenovirus receptor (CXADR) is a member of the immunoglobulin protein superfamily, present in various epithelial cells including glomerular epithelial cells...
  30. doi Synergistic effect of interferon-gamma and tumor necrosis factor-alpha on coxsackievirus and adenovirus receptor expression: an explanation of cell sloughing during testicular inflammation in mice
    Ying Gao
    School of Biological Sciences, The University of Hong Kong, Hong Kong, People s Republic of China
    Biol Reprod 90:59. 2014
    Coxsackievirus and adenovirus receptor (CAR) is a junction molecule that expresses on Sertoli and germ cells...
  31. pmc Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia
    Roos F J Marsman
    Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 63:549-59. 2014
    The aim of this study was to investigate the modulatory effect of the coxsackie and adenovirus receptor (CAR) on ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
  32. pmc The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP)
    Nadia Houri
    Department of Neurology and Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e73296. 2013
    The Coxsackievirus and Adenovirus Receptor (CAR) is a cell adhesion molecule originally characterized as a virus receptor but subsequently shown to be involved in physiological processes such as neuronal and heart development, epithelial ..
  33. doi Hepatic damage caused by coxsackievirus B3 is dependent on age-related tissue tropisms associated with the coxsackievirus-adenovirus receptor
    Jung Yen Liu
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
    Pathog Dis 68:52-60. 2013
    ..This study was designed to explore the role of coxsackievirus-adenovirus receptor (CAR) in the pathogenesis of CVB3-infected hepatocytes via in vitro and mice studies...
  34. doi Down-regulation of coxsakie and adenovirus receptor during embryo implantation
    Yufeng Li
    Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 32:103-6. 2012
    In this study, real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression. Both localization and quantity were evaluated in the uteri obtained at days post coitus (dpc) 2.5, 4.5, 6.5, 8.5...
  35. pmc The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry
    Fabien Loustalot
    Institut de Genetique Moleculaire de Montpellier, CNRS, Montpellier, France Université de Montpellier, Montpellier, France
    J Virol 89:9417-26. 2015
    The coxsackievirus and adenovirus receptor (CAR) is a cell adhesion molecule used as a docking molecule by some adenoviruses (AdVs) and group B coxsackieviruses...
  36. doi Coxsackievirus and Adenovirus Receptor, a Tight Junction Protein, in Peri-Implantation Mouse Embryos
    Yeong Seok Oh
    Department of Life Science and Research Institute for Natural Sciences, Hanyang University, Seoul, Korea
    Biol Reprod 95:5. 2016
    To understand the role of Coxsackievirus and adenovirus receptor (CAR), a tight junction (TJ) protein, in peri-implantation embryos, developmental expression of CAR and its role in paracellular permeability were examined in mouse embryos...
  37. doi Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity
    Charleine Zussy
    Institut de Genetique Moleculaire de Montpellier, Centre National de la Recherche Scientifique 5535, 34293 Montpellier, France, Universite de Montpellier, 34000 Montpellier, France
    J Neurosci 36:9558-71. 2016
    ..Here, we demonstrate that in the adult brain, the coxsackievirus and adenovirus receptor (CAR) is located on neuron projections, at the presynapse in mature neurons, and on the soma of immature neurons in the ..
  38. doi Inhibition of the protein tyrosine phosphatase SHP-1 increases glucose uptake in skeletal muscle cells by augmenting insulin receptor signaling and GLUT4 expression
    Sebastien Bergeron
    Department of Medicine, Faculty of Medicine, Cardiology Axis of Quebec Heart and Lung Institute, Ste Foy, Quebec, Canada
    Endocrinology 152:4581-8. 2011
    ....
  39. pmc Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice
    Momina Mirza
    Department of Women s and Children s Health, Karolinska Institute and University Hospital, Stockholm, Sweden
    PLoS ONE 7:e37523. 2012
    ..To address this, we generated mice carrying a conditional deletion of the CAR gene (Cxadr) and knocked out CAR in the mouse embryo at different time points during post-cardiac development...
  40. ncbi Characterization of a cDNA encoding the bovine coxsackie and adenovirus receptor
    I Thoelen
    Laboratory of Clinical and Epidemiological Virology, University of Leuven, Belgium
    Biochem Biophys Res Commun 288:805-8. 2001
    ..Recombinant human subgroup C adenovectors use the coxsackie and adenovirus receptor (CAR) to enter their target cells...
  41. ncbi The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear development
    Katherine J D A Excoffon
    Department of Internal Medicine, Division of Pulmonary Medicine, University of Iowa, 440 EMRB, Iowa City, IA 52242, USA
    Hear Res 215:1-9. 2006
    ..The gene for CAR, CXADR, is located within the genomic locus for Usher syndrome type 1E (USH1E)...
  42. ncbi Mouse adenovirus type 1 attachment is not mediated by the coxsackie-adenovirus receptor
    L Lenaerts
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    FEBS Lett 580:3937-42. 2006
    Common human adenovirus (Ad) vectors are derived from serotype 2 or 5, which use the coxsackie-adenovirus receptor (CAR) as their primary cell receptor...
  43. ncbi Expression of Coxsackie-Adenovirus receptor (CAR) in the developing mouse olfactory system
    Giri Venkatraman
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Neurocytol 34:295-305. 2005
    ..The Coxsackie-Adenovirus receptor (CAR) and members of the integrin family have been implicated in the process of AdV infection in various systems...
  44. ncbi Structure and chromosomal localization of the murine coxsackievirus and adenovirus receptor gene
    Jin Wen Chen
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 22:253-9. 2003
    We analyzed BAC genomic clones encoding the murine coxsackievirus and adenovirus receptor (mCAR)...
  45. ncbi Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP
    K Kawabata
    Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation, Osaka, Japan
    Gene Ther 14:1199-207. 2007
    Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily and a component of epithelial tight junction. CAR also functions as a primary receptor for coxsackievirus B and adenovirus (Ad) infection...
  46. ncbi Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells
    Manabu Yamashita
    National Institute of Biomedical Innovation, Ibaraki, Osaka 567 0085, Japan
    Int J Cancer 121:1690-6. 2007
    The coxsackie and adenovirus receptor (CAR) is involved in the epithelial cell tight junction, the downregulated expression of which is observed in different cancer types...
  47. doi Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus-adenovirus receptor during viral myocarditis
    Volker Ruppert
    Department of Cardiology, University of Marburg, Marburg, Germany
    Cardiovasc Pathol 17:81-92. 2008
    The coxsackievirus-adenovirus receptor (CAR) was originally described as a transmembrane protein involved in viral infection and was later found to be required for normal heart development...
  48. ncbi Binding of adenovirus to its receptors in mouse astrocytes induces c-fos proto-oncogene and apoptosis
    Nazario Rubio
    Department of Neuroimmunology, Instituto Cajal, C S I C, Dr Arce Avenue 37, Madrid, Spain
    Virology 297:211-9. 2002
    ..The purpose of our study was to ascertain the potential for adenovirus as a gene therapy vector for neural disorders caused by astrocyte dysfunctions...
  49. pmc Gene transfer using liposome-complexed adenovirus seems to overcome limitations due to coxsackievirus and adenovirus receptor-deficiency of cancer cells, both in vitro and in vivo
    Sang Young Han
    Department of Internal Medicine, Dong A University College of Medicine Busan 602 714, Korea
    Exp Mol Med 40:427-34. 2008
    ..therapy requires that target cells express appropriate receptors such as coxsakievirus and adenovirus receptor (CAR)...
  50. doi Regulatory T cells protect mice against coxsackievirus-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway
    Yu Shi
    Division of Cardiology, Heart and Stroke Richard Lewar Centre of Excellence, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada
    Circulation 121:2624-34. 2010
    ..This study was designed to test the protective effects of Tregs and to determine the underlying mechanisms...
  51. pmc CAR-associated vesicular transport of an adenovirus in motor neuron axons
    Sara Salinas
    Molecular Neuropathobiology Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
    PLoS Pathog 5:e1000442. 2009
    ..we show that interaction with the neuronal membrane correlates with coxsackievirus and adenovirus receptor (CAR) surface expression, followed by endocytosis involving clathrin...
  52. pmc Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease
    Bingning Dong
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:18831-6. 2009
    Constitutive androstane receptor CAR (NR1I3) has been identified as a central mediator of coordinate responses to xenobiotic and endobiotic stress...
  53. doi The coxsackie-adenovirus receptor induces an inflammatory cardiomyopathy independent of viral infection
    Stella Yuen
    Cell Biology Program, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    J Mol Cell Cardiol 50:826-40. 2011
    ..transgenic mice under the control of a tetracycline-responsive (tet-off) α-myosin heavy chain (αMtTA) promoter (mCAR(+)/αMtTA(+) mice)...
  54. doi Expression of coxsackievirus and adenovirus receptor isoforms in developing mouse bladder uroepithelium
    Myung Chan Gye
    Department of Life Science, Hanyang University College of Natural Sciences, Seoul Korea
    Urology 77:1009.e9-1009.e18. 2011
    ..In the present study, we examined the developmental changes in the expression of coxsackievirus and adenovirus receptor (CAR) isoforms in mouse bladder uroepithelium.
  55. doi Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants
    M A Gray
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    Xenobiotica 39:915-30. 2009
    ..androstane receptor (CAR; NR1I3) was cloned and compared for homology and activity with mouse and human CAR (mCAR, hCAR). Porcine CAR (pgCAR) was 86% and 75% homologous to hCAR at the nucleotide and protein levels...
  56. ncbi Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting
    C J Cohen
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Biol Chem 276:25392-8. 2001
    The coxsackievirus and adenovirus receptor (CAR) mediates attachment and infection by coxsackie B viruses and many adenoviruses...

Research Grants5

  1. MYOCARDITIS--RECEPTORS FOR A CARDIOTROPIC VIRUS
    Jeffrey Bergelson; Fiscal Year: 2001
    ..We have now purified and cloned another- --novel---cell surface protein, CAR, that functions both in attachment and infection by all six coxsackie B serotypes...
  2. Expression of the coxsackievirus and adenovirus receptor
    Christopher Cohen; Fiscal Year: 2002
    ..coxsackieviruses and many adenoviruses initiate infection by binding to the coxsackievirus and adenovirus receptor (CAR)...
  3. Naturalization-Resistant Adenovirus Vaccine Vector
    Jeffrey Bergelson; Fiscal Year: 2005
    ..Such a chimeric vector could solve one of the major obstacles to the use of adenovirus vectors for HIV immunization. ..
  4. Junction Adhesion Molecule CAR and the Immune System
    Steven Carson; Fiscal Year: 2007
    b>CAR is a junction adhesion molecule (JAM), similar to other known JAM proteins. These proteins generally localize to tight junctions, where they participate in cell-cell adhesion and link to cytoplasmic proteins...
  5. Cell Biology of Enterovirus Infection in Polarized Epithelial Cells
    Jeffrey Bergelson; Fiscal Year: 2007
    ..and virus movement to the tight junction, where interaction with the coxsackievirus and adenovirus receptor (CAR) initiates the uncoating process that releases viral RNA; activation of Fyn kinase triggers virus internalization ..