Ctsb

Summary

Gene Symbol: Ctsb
Description: cathepsin B
Alias: cathepsin B, cathepsin B1
Species: mouse

Top Publications

  1. pmc Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    W Halangk
    Department of Surgery, Division of Experimental Surgery, Otto von Guericke Universitat, Magdeburg, Germany
    J Clin Invest 106:773-81. 2000
  2. pmc Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
    M E Guicciardi
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 106:1127-37. 2000
  3. pmc Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications
    M E Guicciardi
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 159:2045-54. 2001
  4. ncbi Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells
    Daniel H Ebert
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:24609-17. 2002
  5. pmc Neuronal loss and brain atrophy in mice lacking cathepsins B and L
    Ute Felbor
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:7883-8. 2002
  6. ncbi Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells
    Lasse Foghsgaard
    Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    J Biol Chem 277:39499-506. 2002
  7. pmc Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation
    Ana Maria Lennon-Dumenil
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    J Exp Med 196:529-40. 2002
  8. ncbi Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice
    Kanae Shirahama-Noda
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    J Biol Chem 278:33194-9. 2003
  9. pmc Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
    Kartik Chandran
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 308:1643-5. 2005
  10. pmc Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells
    Eunok Im
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Mol Biol Cell 16:3488-500. 2005

Scientific Experts

  • S Ya Zhanaeva
  • Niamh Murphy
  • Mark S Kindy
  • Vincent Everts
  • Ludwig Czibere
  • David R C Natale
  • Gloria Lopez-Castejon
  • Linnzi M Furman
  • I Podgorski
  • J A Gogos
  • G J Gores
  • Li Gan
  • Rahamim Gadba
  • V Y Hook
  • C Rocken
  • U Felbor
  • S Afonso
  • Thomas Reinheckel
  • Christoph Peters
  • Vasilena Gocheva
  • Prajwal Gurung
  • Soon Duck Ha
  • Binggui Sun
  • Lisa Sevenich
  • Susan M Byrne
  • Hiroshi Nakanishi
  • Zhou Wu
  • Paul Saftig
  • Jan Deussing
  • Johanna A Joyce
  • M E Guicciardi
  • Yungui Zhou
  • Yasuo Uchiyama
  • Kartik Chandran
  • Xiaopeng Qi
  • Daniel H Ebert
  • Thirumala Devi Kanneganti
  • Olga Vasiljeva
  • Tian Lei
  • Junjun Ni
  • Ryan P McGlinchey
  • Sarah Mueller-Steiner
  • Krithika Rajaram
  • Euan Ramsay Orr Allan
  • Parisa Kalantari
  • Rebekka Kubisch
  • Arvind Dev
  • Lee S Jacobson
  • C Peters
  • Stefan Tholen
  • Terence S Dermody
  • Philip G Ashton-Rickardt
  • Jin Wu Zhou
  • Katherine A Fitzgerald
  • Pieter Steenhuis
  • Chao Wang
  • Andrea Marzi
  • Shinji Noda
  • Eicke Latz
  • A M Amarante-Paffaro
  • Tobias Hoegen
  • Gail Miller
  • Rene Maehr
  • Leslie Guery
  • Ruth Bejarano-Escobar
  • Kanae Shirahama-Noda
  • T Meister
  • Anja Bernhardt
  • Kayo Terada
  • Li Sun
  • Kenji Yamamoto
  • Lianne C Hsing
  • Peter Duewell
  • Anders Grubb
  • Hidde L Ploegh
  • Elizabeth M Johnson
  • Anna Vreemann
  • Jian Tao Ye
  • Brooke K McMichael
  • Sung Hee Chang
  • Anna Moles
  • Sung Ouk Kim
  • Joseph A Duncan
  • Olaf Gross
  • Dejan Caglic
  • O Vasiljeva
  • S F Bronk
  • Chun Tu
  • Sebastien Conus
  • J Deussing

Detail Information

Publications110 found, 100 shown here

  1. pmc Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    W Halangk
    Department of Surgery, Division of Experimental Surgery, Otto von Guericke Universitat, Magdeburg, Germany
    J Clin Invest 106:773-81. 2000
    ..of digestive zymogens is unknown, but a recent hypothesis predicts that a redistribution of lysosomal cathepsin B (CTSB) into a zymogen-containing subcellular compartment triggers this event...
  2. pmc Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
    M E Guicciardi
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 106:1127-37. 2000
    TNF-alpha-induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine protease, has recently been implicated in apoptosis...
  3. pmc Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications
    M E Guicciardi
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 159:2045-54. 2001
    ..Recent evidence suggests that cathepsin B (cat B) contributes to TNF-alpha-induced apoptosis in vitro...
  4. ncbi Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells
    Daniel H Ebert
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:24609-17. 2002
    ..In contrast, both L929 cells treated with the cathepsin B inhibitor CA-074Me and cathepsin B-deficient mouse embryo fibroblasts support reovirus disassembly and growth...
  5. pmc Neuronal loss and brain atrophy in mice lacking cathepsins B and L
    Ute Felbor
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:7883-8. 2002
    ..b>Cathepsin B(-/-)/L(-/-) mice reveal a degree of brain atrophy not previously seen in mice...
  6. ncbi Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells
    Lasse Foghsgaard
    Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    J Biol Chem 277:39499-506. 2002
    ..Here, we show that cathepsin B-like proteases are required for the TNF-induced AA release in transformed cells...
  7. pmc Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation
    Ana Maria Lennon-Dumenil
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    J Exp Med 196:529-40. 2002
    ..Phagosomal maturation is therefore a tightly regulated process that varies according to the type and differentiation stage of the phagocyte...
  8. ncbi Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice
    Kanae Shirahama-Noda
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    J Biol Chem 278:33194-9. 2003
    ..Thus, the AEP deficiency caused the accumulation of macromolecules in the lysosomes, highlighting a pivotal role of AEP in the endosomal/lysosomal degradation system...
  9. pmc Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
    Kartik Chandran
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 308:1643-5. 2005
    ..Using selective protease inhibitors and protease-deficient cell lines, we identified an essential role for cathepsin B (CatB) and an accessory role for cathepsin L (CatL) in EboV GP-dependent entry...
  10. pmc Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells
    Eunok Im
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Mol Biol Cell 16:3488-500. 2005
    The lysosomal protease cathepsin B has been implicated in a variety of pathologies including pancreatitis, tumor angiogenesis, and neuronal diseases. We used a tube formation assay to investigate the role of cathepsin B in angiogenesis...
  11. ncbi Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice
    Rene Maehr
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:7066-74. 2005
    ..We conclude that AEP is essential for processing of Cat L but not for class II MHC-restricted Ag presentation...
  12. pmc Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)
    Masato Koike
    Department of Cell Biology and Neurosciences, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Pathol 167:1713-28. 2005
    ..These data strongly argue for a major involvement of autophagy in the pathogenesis of Batten disease/lysosomal storage disorders...
  13. pmc Distinct roles for cysteine cathepsin genes in multistage tumorigenesis
    Vasilena Gocheva
    Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 20:543-56. 2006
    ..Mutants of cathepsins B or S impaired tumor formation and angiogenesis, while cathepsin B or L knockouts retarded cell proliferation and tumor growth...
  14. ncbi Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer
    Olga Vasiljeva
    Institut für Molekulare Medizin und Zellforschung and Institut für Biometrie und Medizinische Informatik, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    Cancer Res 66:5242-50. 2006
    ..mouse mammary tumor virus-polyoma middle T antigen (PyMT) transgenic mice deficient for the cysteine protease cathepsin B (CTSB) exhibited a significantly delayed onset and reduced growth rate of mammary cancers compared with wild-..
  15. ncbi Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice
    Lisa Sevenich
    Institut für Molekulare Medizin und Zellforschung, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    Biol Chem 387:885-91. 2006
    b>Cathepsin B (CTSB) and cathepsin L (CTSL) are two widely expressed cysteine proteases thought to predominantly reside within lysosomes...
  16. ncbi Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes
    Sonja Stahl
    Department of Human Genetics, University of Wurzburg, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
    Biochim Biophys Acta 1774:1237-46. 2007
    ..tagging for relative and absolute quantitation (iTRAQ) allowed us to simultaneously assess wildtype and cathepsin B(-/-)L(-/-) cerebral lysosomes...
  17. ncbi Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages
    Soon Duck Ha
    Department of Microbiology and Immunology, Siebens Drake Research Institute, University of Western Ontario, London, Ontario, Canada
    J Immunol 181:690-7. 2008
    ..We found that cathepsin B, a lysosomal cysteine proteinase, was required for optimal posttranslational processing of TNF-alpha in ..
  18. doi Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery
    Dejan Caglic
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 390:175-9. 2009
    ..It is important, therefore, to know whether similar differences exist between murine and human cathepsin B. Thus, both enzymes were expressed and biochemically characterized...
  19. pmc Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
    Anna Moles
    Department of Cell Death and Proliferation, Instituto Investigaciones Biomedicas de Barcelona, Consejo Superior de Investigaciones Cientificas, Centro de Investigaciones Biomédicas Esther Koplowitz, Hospital Clinic, Barcelona, Spain
    Hepatology 49:1297-307. 2009
    ..Here, we show that expression of cathepsin B (CtsB) and cathepsin D (CtsD) is negligible in quiescent HSCs but parallels the increase of alpha-smooth muscle ..
  20. pmc VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation
    Sung Hee Chang
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 69:4537-44. 2009
    ..angiogenesis in the Matrigel assay, and Ad-VEGF-A(164)-induced angiogenesis was reduced by approximately 50% in cathepsin B-null mice...
  21. pmc Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein
    Vivian Y H Hook
    Depts of Neurosciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0744, USA
    Biochem Biophys Res Commun 386:284-8. 2009
    ..This study shows that knockout of the cathepsin B gene in mice expressing human wild-type APP (hAPPwt) results in substantial decreases in brain Abeta40 and ..
  22. pmc Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
    J Deussing
    Abteilung Innere Medizin I, Albert Ludwigs Universitat Freiburg, Freiburg, 79106 Germany
    Proc Natl Acad Sci U S A 95:4516-21. 1998
    ..Degradation of Ii proceeded normally in Cat B-/- splenocytes, as it did in Cat D-/- cells. We conclude that neither Cat B nor Cat D are essential for MHC class II-mediated antigen presentation...
  23. pmc Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome
    S Gruenheid
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Exp Med 185:717-30. 1997
    ....
  24. ncbi Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach
    Li Gan
    AGY Therapeutics, Inc, South San Francisco, California 94080, USA
    J Biol Chem 279:5565-72. 2004
    ..reverse transcription-PCR was used to confirm the regulation of a subset of genes, including cysteine proteases cathepsin B and cathepsin L, tissue inhibitor of matrix metalloproteinase 2, cytochrome c oxidase, and allograft ..
  25. ncbi A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins
    Neeraj Tiwari
    Department of Molecular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Immunol 178:7932-42. 2007
    ..Thus, endosomal processing of internalized endogenous transmembrane proteins represents a novel alternate pathway for the generation of MHC-I-binding peptides...
  26. doi Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain
    Jian Tao Ye
    Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, East of Waihuan Road, City of Universities, Guangzhou 510006, China
    Neuroreport 20:1456-60. 2009
    ..model to investigate the alterations in mRNA expression of Abeta precursor protein cleavage enzyme 1(BACE1), cathepsin B, and glutaminyl cyclase after transient global cerebral ischemia...
  27. pmc Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection
    Anja Bernhardt
    Institute of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Biol Chem 285:33691-700. 2010
    ..Primary epithelial cells from stomach of Ctsx(-/-) mice represent an excellent model of H. pylori gastritis to elaborate the special functions of Ctsx in regulating the immune response to H. pylori...
  28. doi Asparagine endopeptidase is required for normal kidney physiology and homeostasis
    Gail Miller
    Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee, UK
    FASEB J 25:1606-17. 2011
    ..Thus, AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor...
  29. doi Macrophage and microglia ontogeny in the mouse visual system can be traced by the expression of Cathepsins B and D
    Ruth Bejarano-Escobar
    Departamento de Biologia Celular, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain
    Dev Dyn 240:1841-55. 2011
    Here, we show a detailed chronotopographical analysis of cathepsin B and D expression during development of the mouse visual system...
  30. pmc Fine-tuning nucleophosmin in macrophage differentiation and activation
    Leslie Guery
    Inserm Unite Mixte de Recherche, Faculte de Medecine, Dijon, France
    Blood 118:4694-704. 2011
    ..The protein is further cleaved into a 20-kDa fragment, which involves cathepsin B. NPM1 fragments contribute to the limited motility, migration, and phagocytosis capabilities of resting ..
  31. pmc Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice
    Ludwig Czibere
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 6:e23604. 2011
    ..in the basal expression of 13 candidate genes, using tissue from the entire brain, including coronin 7 (Coro7), cathepsin B (Ctsb), muscleblind-like 1 (Mbnl1), metallothionein 1 (Mt1), solute carrier family 25 member 17 (Slc25a17), ..
  32. doi The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release
    Tobias Hoegen
    Department of Neurology, Clinic of the University of Munich, D 81377 Munich, Germany
    J Immunol 187:5440-51. 2011
    ..The latter depends on the release of ATP, lysosomal destabilization (but not disruption), and cathepsin B activation...
  33. doi The activity and mRNA expression of β-secretase, cathepsin D, and cathepsin B in the brain of senescence-accelerated mouse
    Jin Wu Zhou
    Beijing Institute of Pharmacology and Toxicology, Beijing, China
    J Alzheimers Dis 28:471-80. 2012
    ..There was no significant difference between SAMP8 and SAMR1 with regards to activity of cathepsin B. β-secretase activity had a positive correlation with cathepsin D activity in the cerebral cortex of SAMR1 and ..
  34. pmc A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis
    Shinji Noda
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 7:e32272. 2012
    b>Cathepsin B (CTSB) is a proteolytic enzyme potentially modulating angiogenic processes and extracellular matrix remodeling...
  35. doi Activation of the P2X₇ receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1
    Niamh Murphy
    Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    J Neurochem 123:761-70. 2012
    ..and increase MMP-9 activity, which is coupled with a decrease in release of TIMP-1 and an increase in activated cathepsin B within the extracellular space. This process occurs independently of NLRP3-inflammasome formation...
  36. pmc Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants
    Lee S Jacobson
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 288:7481-91. 2013
    ..Together our findings suggest that necrotic cell death is a powerful mediator of a Th2-associated immune response...
  37. doi V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo
    Rebekka Kubisch
    Pharmaceutical Biotechnology Department of Pharmacy, Ludwig Maximilians University, Munich, Germany
    Int J Cancer 134:2478-88. 2014
    ..In particular, archazolid induced the secretion of the proforms of cathepsin B and D...
  38. ncbi Activation of cathepsins B and L in mouse lymphosarcoma tissue under the effect of cyclophosphamide is associated with apoptosis induction and infiltration by mononuclear phagocytes
    S Ya Zhanaeva
    Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia
    Bull Exp Biol Med 156:86-90. 2013
    ..It seems that the increase in cathepsins B and L activities in LS tissues was caused by cyclophosphamide induction of apoptosis and depended on the level of tumor cell infiltration with mononuclear phagocytes. ..
  39. pmc Chlamydia muridarum infection of macrophages elicits bactericidal nitric oxide production via reactive oxygen species and cathepsin B
    Krithika Rajaram
    Department of Biology, Indiana University, Bloomington, Indiana, USA
    Infect Immun 83:3164-75. 2015
    ..A hydroxyl radical scavenger and inhibitors of inducible nitric oxide synthase (iNOS) and cathepsin B also reversed chlamydial killing...
  40. pmc Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis
    Euan Ramsay Orr Allan
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Alberta, Canada
    PLoS ONE 10:e0128945. 2015
    ..MOG) was efficiently processed and presented by macrophages to CD4+ T cells in the individual absence of cathepsin B, S or L...
  41. pmc Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
    Ryan P McGlinchey
    Laboratory of Molecular Biophysics, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 112:9322-7. 2015
    ..brain and liver lysosomal extracts and individual human cathepsins demonstrate a direct involvement of cysteine cathepsin B (CtsB) and L (CtsL). Both CtsB and CtsL cleave α-syn within its amyloid region and circumvent fibril formation...
  42. doi The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage
    Junjun Ni
    Department of Aging Science and Pharmacology, Faculty of Dental Science, and
    J Neurosci 35:12488-501. 2015
    Proteinase cascades are part of the basic machinery of neuronal death pathways. Neuronal cathepsin B (CatB), a typical cysteine lysosomal protease, plays a critical role in neuronal death through lysosomal leakage or excessive autophagy...
  43. pmc IGF-1 promotes the growth and metastasis of hepatocellular carcinoma via the inhibition of proteasome-mediated cathepsin B degradation
    Tian Lei
    Tian Lei, Department of Gastroenterology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China
    World J Gastroenterol 21:10137-49. 2015
    ..To investigate the molecular mechanisms of the high IGF-1 level linking diabetes and cancers, which is a risk factor...
  44. pmc NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 113:4452-7. 2016
    ..In conclusion, our studies have uncovered the combined actions of the NLRP3 inflammasome and caspase 8 leading to IL-1β maturation and the directionality of IL-1β in driving disease inPstpip2(cmo)mice. ..
  45. pmc Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
    Xiaopeng Qi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Exp Med 213:2081-97. 2016
    ..In this study, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and autophagy...
  46. doi P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases
    Gloria Lopez-Castejon
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 185:2611-9. 2010
    ..bone marrow-derived macrophages and found that ATP induced rapid release of the lysosomal cysteine proteases cathepsin B, K, L, and S and that was independent of the presence of the proinflammatory cytokines IL-1beta and IL-18...
  47. pmc Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria
    Parisa Kalantari
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 6:196-210. 2014
    ..Finally, infected erythrocytes activated both the NLRP3 and AIM2 inflammasomes. These observations suggest that Hz and DNA work together to induce systemic inflammation during malaria. ..
  48. doi Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7
    Pieter Steenhuis
    Department of Biochemistry, Children s Hospital, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Biochim Biophys Acta 1822:1617-28. 2012
    ..Our findings suggest that CLN7 is inactivated by proteolytic cleavage and that enhanced CLN7 proteolysis caused by missense mutations in selected luminal loops is associated with disease...
  49. pmc Cathepsin B controls the persistence of memory CD8+ T lymphocytes
    Susan M Byrne
    Section of Immunobiology, Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom
    J Immunol 189:1133-43. 2012
    ..Spi2A protected memory cells from lysosomal breakdown by inhibiting cathepsin B. The impaired maintenance of Spi2A-deficient memory CD8(+) T cells was rescued by concomitant cathepsin B ..
  50. pmc Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein
    Chao Wang
    Gladstone Institute of Neurological Diseases, San Francisco, California 94158, USA
    J Biol Chem 287:39834-41. 2012
    ..Previously, we showed that the cysteine protease cathepsin B (CatB) degrades Aβ, most likely by C-terminal truncation, in mice expressing human amyloid precursor protein ..
  51. pmc Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome
    Stefan Tholen
    Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany
    Mol Cell Proteomics 12:611-25. 2013
    ..In stark contrast, mice deficient in cathepsin B (Ctsb) do not display an overt skin phenotype...
  52. pmc Cathepsin B & L are not required for ebola virus replication
    Andrea Marzi
    Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS Negl Trop Dis 6:e1923. 2012
    ..Later in this pathway endosomal acidification activates the cysteine proteases Cathepsin B and L (CatB, CatL), which have been shown to cleave ZEBOV-GP leading to subsequent exposure of the putative ..
  53. pmc Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins
    Arvind Dev
    Center of Excellence in Stem Cell Biology and Regenerative Medicine COBRE, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    J Exp Med 210:225-32. 2013
    ..Spi2A defects were ameliorated by cathepsin-B/L inhibition, and by genetic co-deletion of lysosomal cathepsin B. Pharmacological inhibition of cathepsin B/L enhanced EPO-induced red cell formation in normal mice...
  54. ncbi Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst
    A Dardik
    Department of Biology, University of Pennsylvania, Philadelphia 19104
    Dev Biol 154:396-409. 1992
    ..The co-localization of TGF-alpha and functional EGFRs to the ICM and polar TE suggests potential autocrine, juxtacrine, and paracrine roles for TGF-alpha in blastocyst development...
  55. ncbi The structure of the mouse cathepsin B gene and its putative promoter
    F Qian
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637
    DNA Cell Biol 10:159-68. 1991
    The mouse cathepsin B gene and its flanking regions were cloned and characterized. The gene contains 10 exons and 9 introns spanning about 20 kb...
  56. ncbi Gene structure of mouse cathepsin B
    M Ferrara
    Unité de Recherches sur l Expression des Protéases, SRV Theix, Institut National de la Recherche Agronomique, Ceyrat, France
    FEBS Lett 273:195-9. 1990
    The structure of a genomic DNA fragment encoding mouse cathepsin B was characterized. The genomic insert spans 15 kbp and contains 9 exons encoding the 339 amino acid residues of mouse preprocathepsin B...
  57. pmc Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs
    S J Chan
    Proc Natl Acad Sci U S A 83:7721-5. 1986
    b>Cathepsin B is a lysosomal thiol proteinase that may have additional extralysosomal functions...
  58. ncbi Multiple leader sequences for mouse cathepsin B mRNA?
    H Rhaissi
    Unité Expression des Protéases Lysosomales, INRA Theix, Saint Genes Champanelle, France
    Biochimie 75:899-904. 1993
    We previously described the gene structure of murine cathepsin B. Our results suggested that the 5'-untranslated region (leader) is interrupted by a large intron. The second exon (exon-2) contains the translation initiation site...
  59. pmc Gene trapping in differentiating cell lines: regulation of the lysosomal protease cathepsin B in skeletal myoblast growth and fusion
    J A Gogos
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biol 134:837-47. 1996
    ..The first gene we have identified with this strategy is the lysosomal cysteine protease cathepsin B. Expression from the trapped allele is upregulated during early myoblast fusion and downregulated in myotubes...
  60. ncbi Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brain
    N Malgaretti
    Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute HSR, I 20132 Milan, Italy
    J Biol Chem 272:17632-9. 1997
    ....
  61. ncbi The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation
    S Afonso
    Department of Cell, Developmental and Neurobiology, Nelson Labs, Busch Campus, Rutgers University, Piscataway, NJ 08855, USA
    Development 124:3415-25. 1997
    ..Northern blots showed that trophoblast expressed cathepsin B throughout the invasive period (days 5.5-10.5)...
  62. ncbi Cathepsin expression during skeletal development
    M Soderstrom
    Skeletal Research Program, Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
    Biochim Biophys Acta 1446:35-46. 1999
    ..a panel of total RNAs isolated from 16-19 different human and mouse tissues revealed the presence of mRNAs for cathepsin B, H, K, L and S in most tissues, but each with a distinct profile...
  63. ncbi Expression of cysteine proteases in extraembryonic tissues during mouse embryogenesis
    K Sol-Church
    Department of Research, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, Delaware, 19803, USA
    Arch Biochem Biophys 372:375-81. 1999
    The expression of cathepsin B- and L-specific mRNAs as well as active forms of the enzymes was determined in mouse placenta and visceral yolk sac from 7.5 through 17...
  64. ncbi Expression of cathepsin proteinases by mouse trophoblast in vivo and in vitro
    S Afonso
    Department of Cell Biology and Neuroscience, Nelson Labs, Rutgers University, Piscataway, NJ 08855, USA
    Dev Dyn 216:374-84. 1999
    ....
  65. ncbi Molecular characterization of putative yolk processing enzymes and their expression during oogenesis and embryogenesis in rainbow trout (Oncorhynchus mykiss)
    J Y Kwon
    School of Biological Sciences, University of Exeter, Exeter EX4 4PS, United Kingdom
    Biol Reprod 65:1701-9. 2001
    ..In this study we cloned three putative yolk processing enzymes; specifically, cathepsin B and L, and lipoprotein lipase (LPL), from the rainbow trout ovary and determined their patterns of gene ..
  66. pmc Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
    Ali Canbay
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 112:152-9. 2003
    Although a lysosomal, cathepsin B-dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this pathway to tissue damage remains unclear...
  67. ncbi Up-regulation of cathepsin B and cathepsin L activities in scrapie-infected mouse Neuro2a cells
    Yonghua Zhang
    Department of Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Gen Virol 84:2279-83. 2003
    ..We hypothesize that lysosomal proteases may be involved in a 'second autocatalytic loop' of PrP(Sc) formation, acting in concert with the well-known autocatalytic enhancement of PrP conversion in the presence of PrP(Sc)...
  68. ncbi Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)
    Megan K Houseweart
    Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305, USA
    J Neurobiol 56:315-27. 2003
    ..L or S from cystatin B-deficient mice did not ameliorate any aspect of the EPM1 phenotype, removal of cathepsin B resulted in a 36-89% reduction in the amount of cerebellar granule cell apoptosis depending on mouse age...
  69. ncbi Cathepsin B Is Inhibited in Mutant Cells Selected during Persistent Reovirus Infection
    Daniel H Ebert
    Departments of Microbiology and Immunology and Pediatrics and Elizabeth B Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    J Biol Chem 279:3837-51. 2004
    ..contrast to parental L cells, mutant LX cells harbor defects that interfere with the maturation and activity of cathepsin B and cathepsin L but not cathepsin H...
  70. ncbi Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo
    Lianjun Shen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Immunity 21:155-65. 2004
    ..Therefore, cathepsin S plays a major role in generating presented peptides for the vacuolar pathway of crosspresentation, and this mechanism is active in vivo...
  71. ncbi Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury
    E S Baskin-Bey
    Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 288:G396-402. 2005
    ..Wild-type and cathepsin B-knockout (Ctsb(-/-)) mice were fed the methionine/choline-deficient (MCD) diet for 2 wk to induce hepatic ..
  72. pmc Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 7:207-23. 2005
    ..Because secretion of the cysteine protease cathepsin B is increased in human breast fibroblasts grown on collagen I gels, we analyzed cathepsin B levels and secretion ..
  73. ncbi A role for cathepsin E in the processing of mast-cell carboxypeptidase A
    Frida Henningsson
    Swedish University of Agricultural Sciences, Department of Molecular Biosciences, The Biomedical Centre, Box 575, 751 23 Uppsala, Sweden
    J Cell Sci 118:2035-42. 2005
    ..Taken together, our results indicate that cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and that it has a role in the processing of procarboxypeptidase A into active protease...
  74. ncbi Cathepsin B inactivation attenuates the apoptotic injury induced by ischemia/reperfusion of mouse liver
    Z Ben-Ari
    Liver Institute and Department of Medicine D, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Apoptosis 10:1261-9. 2005
    ..Recently, it was demonstrated that the release of cathepsin B, a cysteine protease, from the cytosol in liver injury induces mitochondrial release of cytochrome c and the ..
  75. ncbi Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone
    Vincent Everts
    Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam, Amsterdam, The Netherlands
    J Bone Miner Res 21:1399-408. 2006
    ..The results support the notion that osteoclasts from different bone sites use different enzymes to degrade the collagenous bone matrix...
  76. ncbi Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease
    Sarah Mueller-Steiner
    Gladstone Institute of Neurological Disease, University of California, San Francisco, 1650 Owens Street, 94158, USA
    Neuron 51:703-14. 2006
    ..The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD brains and has been suspected to increase Abeta production...
  77. ncbi Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis
    C Rocken
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Pathol 210:478-87. 2006
    ..CathL was identified as an amyloid-promoting and CathK as an amyloid-retarding cysteine protease. CathB may only modulate the primary structure of the amyloid peptide without affecting amyloid load...
  78. ncbi Induced expression of cathepsins and cystatin C in a murine model of demyelination
    Jianmei Ma
    Department of Anatomy, Dalian Medical University, Dalian, Liaoning, China
    Neurochem Res 32:311-20. 2007
    ..We propose that in MS, remyelination may be impaired by increasing activity of cathepsins inadequately controlled by cystatin C...
  79. ncbi Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression
    Patrick Geraghty
    Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    J Immunol 178:5871-8. 2007
    ..NE exposure resulted in macrophages, producing significantly greater amounts of cathepsin B and latent and active MMP-2...
  80. ncbi Proteolytic disassembly is a critical determinant for reovirus oncolysis
    Tommy Alain
    Department of Medical Sciences, Clark Smith Integrative Brain Tumor Research Center, Southern Alberta Cancer Research Institute, University of Calgary, Alberta, Canada
    Mol Ther 15:1512-21. 2007
    ..We find that the level of active cathepsin B and L is increased in tumors and that disassembly-restrictive glioma cells support reovirus oncolysis when ..
  81. doi Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice
    O Vasiljeva
    Institut für Molekulare Medizin und Zellforschung, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    Oncogene 27:4191-9. 2008
    Expression levels of the papain-like cysteine protease cathepsin B (Ctsb) have been positively correlated with mammary tumour progression and metastasis; however, its roles in the hallmark processes of malignant growth remain poorly ..
  82. pmc Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease
    Binggui Sun
    Gladstone Institute of Neurological Disease, University of California San Francisco, San Francisco, CA 94158, USA
    Neuron 60:247-57. 2008
    ..Cystatin C (CysC, CST3) is an endogenous inhibitor of cysteine proteases, including cathepsin B (CatB), a recently discovered Abeta-degrading enzyme...
  83. pmc Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts
    Chun Tu
    Eppley Institute for Research in Cancer and Allied Diseases, and UNMC Eppley Cancer Center, Omaha, NE 68198 6805, USA
    Cancer Res 68:9147-56. 2008
    ..Using inhibitors and shRNA-mediated depletion, we show that cathepsin B participates in podosomes-mediated focal matrix degradation and invasion in v-Src-transformed fibroblasts...
  84. doi Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases
    Anna Vreemann
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
    Biol Chem 390:481-92. 2009
    ..of different intestine segments by immunofluorescence microscopy provided evidence for a local release of cathepsin B from cells of individual gut sections shortly after traumatic injury...
  85. doi Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    Olaf Gross
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Nature 459:433-6. 2009
    ..Thus, our results demonstrate the molecular basis for IL-1beta production after fungal infection and identify a crucial function for the Nlrp3 inflammasome in mammalian host defence in vivo...
  86. pmc Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome
    Joseph A Duncan
    Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 182:6460-9. 2009
    ..Additionally, N. gonorrhoeae activates the cysteine protease cathepsin B as measured by the breakdown of a cathepsin B substrate...
  87. doi Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia
    Kayo Terada
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    Glia 58:114-24. 2010
    b>Cathepsin B (CB) is a cysteine lysosomal protease implicated in a number of inflammatory diseases...
  88. pmc Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis
    Elizabeth M Johnson
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Virol 83:9630-40. 2009
    ..Mammalian reoviruses utilize cathepsins B (Ctsb), L (Ctsl), and S (Ctss) for disassembly of the virus outer capsid and activation of the membrane penetration ..
  89. doi Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate
    David R C Natale
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, Calgary, AB, Canada T2N 4N1
    Dev Biol 335:120-31. 2009
    ..These results suggest that Activin rather than TGF-beta (or Nodal) acts directly on TS cells influencing both TS cell maintenance and cell fate, depending on whether the cells are also exposed to FGF4...
  90. pmc Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm
    Soon Duck Ha
    Department of Microbiology and Immunology, Siebens Drake Research Institute, University of Western Ontario, London, Ontario N6G2V4, Canada
    J Biol Chem 285:2120-9. 2010
    ..We found that the cytoplasmic delivery of LF by ANTXR2 was mediated by cathepsin B (CTSB) and required lysosomal fusion with LeTx-containing endosomes...
  91. pmc IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    Vasilena Gocheva
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 24:241-55. 2010
    ..Together, these data establish IL-4 as an important regulator, and cathepsin proteases as critical mediators, of the cancer-promoting functions of TAMs...
  92. pmc Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice
    Lisa Sevenich
    Institute of Molecular Medicine and Cell Research Faculty of Biology, Albert Ludwigs University, Freiburg D 79104, Germany
    Proc Natl Acad Sci U S A 107:2497-502. 2010
    The lysosomal cysteine proteases cathepsin B (Ctsb) and cathepsin Z (Ctsz, also called cathepsin X/P) have been implicated in cancer pathogenesis. Compensation of Ctsb by Ctsz in Ctsb (-/-) mice has been suggested...
  93. pmc NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    Peter Duewell
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1357-61. 2010
    ..induce acute inflammation, which is impaired in mice deficient in components of the NLRP3 inflammasome, cathepsin B, cathepsin L or IL-1 molecules...
  94. doi Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse
    Li Sun
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 399:391-5. 2010
    ..b>Cathepsin B (CB), a typical cysteine lysosomal protease, has been implicated in three major morphologically distinct ..
  95. ncbi Missorting of cathepsin B into the secretory compartment of CI-MPR/IGFII-deficient mice does not induce spontaneous trypsinogen activation but leads to enhanced trypsin activity during experimental pancreatitis--without affecting disease severity
    T Meister
    Department of Medicine B, Westfalische Wilhelms Universitat, Munster, Germany
    J Physiol Pharmacol 61:565-75. 2010
    The lysosomal protease cathepsin B is thought to play a crucial role in the intracellular activation cascade of digestive proteases and in the initiation of acute pancreatitis...
  96. doi Localization of cathepsins D and B at the maternal-fetal interface and the invasiveness of the trophoblast during the postimplantation period in the mouse
    A M Amarante-Paffaro
    Laboratory of Cytochemistry and Immunocytochemistry, Institute of Biology, University of Campinas, Campinas, Brazil
    Cells Tissues Organs 193:417-25. 2011
    ..Cathepsin D, but not cathepsin B, was also detected ultrastructurally in extracellular compartments surrounded by processes of the invading ..
  97. ncbi Isolation of a cathepsin B-encoding cDNA from murine osteogenic cells
    C Freimert
    GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Abteilung für Molekulare Zellpathologie, Neuherberg F R G
    Gene 103:259-61. 1991
    b>Cathepsin B-encoding cDNA (CTSB) clones have been isolated from a lambda gt10 library of a murine osteosarcoma by differential screening during a search for genes which are typically expressed during osteogenic differentiation in mouse ..
  98. ncbi Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potential
    F Qian
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Biochem Biophys Res Commun 202:429-36. 1994
    The highly metastatic B16a melanoma has been shown to express higher levels of cathepsin B (CB) mRNA when compared to the less metastatic variants, B16-F1 and B16-F10, and with normal mouse tissues...
  99. pmc Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
    Kithiganahalli N Balaji
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    J Exp Med 196:493-503. 2002
    ..The potent activity of the impermeant, highly cathepsin B-specific membrane inhibitors CA074 and NS-196 strongly implicates extracellular cathepsin B...
  100. ncbi Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia
    Alexandra Benchoua
    Institut National de la Sante et de la Recherche Medicale, Universite Paris Val de Marne, Crétoil, France
    J Cereb Blood Flow Metab 24:1272-9. 2004
    ..This study investigated the existence of a cross-talk between cathepsin B and proinflammatory caspases in stroke-induced cell death, as recently suggested by in vitro data...

Research Grants9

  1. Oxidized Lipoproteins in Neurodegeneration
    Mark Kindy; Fiscal Year: 2004
    ..These studies should provide insights into the normal function of HDL and SR in the CNS and in the pathogenesis of AD. ..
  2. Neprilysin and Abeta-degradation in Alzheimer's disease
    Mark Kindy; Fiscal Year: 2005
    ..The results generated from this study will help us to understand how Abeta peptides are degraded and may provide a unique therapeutic window for the treatment of AD. ..
  3. Pesticides, Paraoxonase and Alzheimer's Disease
    Mark S Kindy; Fiscal Year: 2010
    ..The focus of this proposal is to understand the function of organophosphates (OPs as symbolic ETs) and interrelationship between ETs and paraoxonase (PON- 1) in oxidative stress and inflammation associated with AD. ..
  4. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  5. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  6. Cathepsin B and cystatin C in AD-related neuronal damage
    Li Gan; Fiscal Year: 2005
    ..We have shown that cathepsin B (CatB) released from Abeta-stimulated microglial cells plays a critical role in microglial-mediated neuronal ..
  7. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  8. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  9. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..