Genomes and Genes
Gene Symbol: Ctsb
Description: cathepsin B
Alias: cathepsin B, cathepsin B1
Publications110 found, 100 shown here
- Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisW Halangk
Department of Surgery, Division of Experimental Surgery, Otto von Guericke Universitat, Magdeburg, Germany
J Clin Invest 106:773-81. 2000..of digestive zymogens is unknown, but a recent hypothesis predicts that a redistribution of lysosomal cathepsin B (CTSB) into a zymogen-containing subcellular compartment triggers this event...
- Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome cM E Guicciardi
Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
J Clin Invest 106:1127-37. 2000TNF-alpha-induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine protease, has recently been implicated in apoptosis...
- Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applicationsM E Guicciardi
Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
Am J Pathol 159:2045-54. 2001..Recent evidence suggests that cathepsin B (cat B) contributes to TNF-alpha-induced apoptosis in vitro...
- Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cellsDaniel H Ebert
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 277:24609-17. 2002..In contrast, both L929 cells treated with the cathepsin B inhibitor CA-074Me and cathepsin B-deficient mouse embryo fibroblasts support reovirus disassembly and growth...
- Neuronal loss and brain atrophy in mice lacking cathepsins B and LUte Felbor
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:7883-8. 2002..b>Cathepsin B(-/-)/L(-/-) mice reveal a degree of brain atrophy not previously seen in mice...
- Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cellsLasse Foghsgaard
Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
J Biol Chem 277:39499-506. 2002..Here, we show that cathepsin B-like proteases are required for the TNF-induced AA release in transformed cells...
- Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activationAna Maria Lennon-Dumenil
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
J Exp Med 196:529-40. 2002..Phagosomal maturation is therefore a tightly regulated process that varies according to the type and differentiation stage of the phagocyte...
- Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient miceKanae Shirahama-Noda
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
J Biol Chem 278:33194-9. 2003..Thus, the AEP deficiency caused the accumulation of macromolecules in the lysosomes, highlighting a pivotal role of AEP in the endosomal/lysosomal degradation system...
- Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infectionKartik Chandran
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Science 308:1643-5. 2005..Using selective protease inhibitors and protease-deficient cell lines, we identified an essential role for cathepsin B (CatB) and an accessory role for cathepsin L (CatL) in EboV GP-dependent entry...
- Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cellsEunok Im
Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
Mol Biol Cell 16:3488-500. 2005The lysosomal protease cathepsin B has been implicated in a variety of pathologies including pancreatitis, tumor angiogenesis, and neuronal diseases. We used a tube formation assay to investigate the role of cathepsin B in angiogenesis...
- Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in miceRene Maehr
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:7066-74. 2005..We conclude that AEP is essential for processing of Cat L but not for class II MHC-restricted Ag presentation...
- Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)Masato Koike
Department of Cell Biology and Neurosciences, Osaka University Graduate School of Medicine, Suita, Japan
Am J Pathol 167:1713-28. 2005..These data strongly argue for a major involvement of autophagy in the pathogenesis of Batten disease/lysosomal storage disorders...
- Distinct roles for cysteine cathepsin genes in multistage tumorigenesisVasilena Gocheva
Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genes Dev 20:543-56. 2006..Mutants of cathepsins B or S impaired tumor formation and angiogenesis, while cathepsin B or L knockouts retarded cell proliferation and tumor growth...
- Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancerOlga Vasiljeva
Institut für Molekulare Medizin und Zellforschung and Institut für Biometrie und Medizinische Informatik, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
Cancer Res 66:5242-50. 2006..mouse mammary tumor virus-polyoma middle T antigen (PyMT) transgenic mice deficient for the cysteine protease cathepsin B (CTSB) exhibited a significantly delayed onset and reduced growth rate of mammary cancers compared with wild-..
- Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient miceLisa Sevenich
Institut für Molekulare Medizin und Zellforschung, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
Biol Chem 387:885-91. 2006b>Cathepsin B (CTSB) and cathepsin L (CTSL) are two widely expressed cysteine proteases thought to predominantly reside within lysosomes...
- Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomesSonja Stahl
Department of Human Genetics, University of Wurzburg, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
Biochim Biophys Acta 1774:1237-46. 2007..tagging for relative and absolute quantitation (iTRAQ) allowed us to simultaneously assess wildtype and cathepsin B(-/-)L(-/-) cerebral lysosomes...
- Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophagesSoon Duck Ha
Department of Microbiology and Immunology, Siebens Drake Research Institute, University of Western Ontario, London, Ontario, Canada
J Immunol 181:690-7. 2008..We found that cathepsin B, a lysosomal cysteine proteinase, was required for optimal posttranslational processing of TNF-alpha in ..
- Murine and human cathepsin B exhibit similar properties: possible implications for drug discoveryDejan Caglic
Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
Biol Chem 390:175-9. 2009..It is important, therefore, to know whether similar differences exist between murine and human cathepsin B. Thus, both enzymes were expressed and biochemically characterized...
- Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potentialAnna Moles
Department of Cell Death and Proliferation, Instituto Investigaciones Biomedicas de Barcelona, Consejo Superior de Investigaciones Cientificas, Centro de Investigaciones Biomédicas Esther Koplowitz, Hospital Clinic, Barcelona, Spain
Hepatology 49:1297-307. 2009..Here, we show that expression of cathepsin B (CtsB) and cathepsin D (CtsD) is negligible in quiescent HSCs but parallels the increase of alpha-smooth muscle ..
- VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formationSung Hee Chang
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Cancer Res 69:4537-44. 2009..angiogenesis in the Matrigel assay, and Ad-VEGF-A(164)-induced angiogenesis was reduced by approximately 50% in cathepsin B-null mice...
- Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor proteinVivian Y H Hook
Depts of Neurosciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0744, USA
Biochem Biophys Res Commun 386:284-8. 2009..This study shows that knockout of the cathepsin B gene in mice expressing human wild-type APP (hAPPwt) results in substantial decreases in brain Abeta40 and ..
- Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentationJ Deussing
Abteilung Innere Medizin I, Albert Ludwigs Universitat Freiburg, Freiburg, 79106 Germany
Proc Natl Acad Sci U S A 95:4516-21. 1998..Degradation of Ii proceeded normally in Cat B-/- splenocytes, as it did in Cat D-/- cells. We conclude that neither Cat B nor Cat D are essential for MHC class II-mediated antigen presentation...
- Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosomeS Gruenheid
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Exp Med 185:717-30. 1997....
- Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approachLi Gan
AGY Therapeutics, Inc, South San Francisco, California 94080, USA
J Biol Chem 279:5565-72. 2004..reverse transcription-PCR was used to confirm the regulation of a subset of genes, including cysteine proteases cathepsin B and cathepsin L, tissue inhibitor of matrix metalloproteinase 2, cytochrome c oxidase, and allograft ..
- A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteinsNeeraj Tiwari
Department of Molecular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Immunol 178:7932-42. 2007..Thus, endosomal processing of internalized endogenous transmembrane proteins represents a novel alternate pathway for the generation of MHC-I-binding peptides...
- Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brainJian Tao Ye
Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, East of Waihuan Road, City of Universities, Guangzhou 510006, China
Neuroreport 20:1456-60. 2009..model to investigate the alterations in mRNA expression of Abeta precursor protein cleavage enzyme 1(BACE1), cathepsin B, and glutaminyl cyclase after transient global cerebral ischemia...
- Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infectionAnja Bernhardt
Institute of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
J Biol Chem 285:33691-700. 2010..Primary epithelial cells from stomach of Ctsx(-/-) mice represent an excellent model of H. pylori gastritis to elaborate the special functions of Ctsx in regulating the immune response to H. pylori...
- Asparagine endopeptidase is required for normal kidney physiology and homeostasisGail Miller
Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee, UK
FASEB J 25:1606-17. 2011..Thus, AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor...
- Macrophage and microglia ontogeny in the mouse visual system can be traced by the expression of Cathepsins B and DRuth Bejarano-Escobar
Departamento de Biologia Celular, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain
Dev Dyn 240:1841-55. 2011Here, we show a detailed chronotopographical analysis of cathepsin B and D expression during development of the mouse visual system...
- Fine-tuning nucleophosmin in macrophage differentiation and activationLeslie Guery
Inserm Unite Mixte de Recherche, Faculte de Medecine, Dijon, France
Blood 118:4694-704. 2011..The protein is further cleaved into a 20-kDa fragment, which involves cathepsin B. NPM1 fragments contribute to the limited motility, migration, and phagocytosis capabilities of resting ..
- Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in miceLudwig Czibere
Max Planck Institute of Psychiatry, Munich, Germany
PLoS ONE 6:e23604. 2011..in the basal expression of 13 candidate genes, using tissue from the entire brain, including coronin 7 (Coro7), cathepsin B (Ctsb), muscleblind-like 1 (Mbnl1), metallothionein 1 (Mt1), solute carrier family 25 member 17 (Slc25a17), ..
- The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B releaseTobias Hoegen
Department of Neurology, Clinic of the University of Munich, D 81377 Munich, Germany
J Immunol 187:5440-51. 2011..The latter depends on the release of ATP, lysosomal destabilization (but not disruption), and cathepsin B activation...
- The activity and mRNA expression of β-secretase, cathepsin D, and cathepsin B in the brain of senescence-accelerated mouseJin Wu Zhou
Beijing Institute of Pharmacology and Toxicology, Beijing, China
J Alzheimers Dis 28:471-80. 2012..There was no significant difference between SAMP8 and SAMR1 with regards to activity of cathepsin B. β-secretase activity had a positive correlation with cathepsin D activity in the cerebral cortex of SAMR1 and ..
- A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosisShinji Noda
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
PLoS ONE 7:e32272. 2012b>Cathepsin B (CTSB) is a proteolytic enzyme potentially modulating angiogenic processes and extracellular matrix remodeling...
- Activation of the P2X₇ receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1Niamh Murphy
Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
J Neurochem 123:761-70. 2012..and increase MMP-9 activity, which is coupled with a decrease in release of TIMP-1 and an increase in activated cathepsin B within the extracellular space. This process occurs independently of NLRP3-inflammasome formation...
- Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvantsLee S Jacobson
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 288:7481-91. 2013..Together our findings suggest that necrotic cell death is a powerful mediator of a Th2-associated immune response...
- V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivoRebekka Kubisch
Pharmaceutical Biotechnology Department of Pharmacy, Ludwig Maximilians University, Munich, Germany
Int J Cancer 134:2478-88. 2014..In particular, archazolid induced the secretion of the proforms of cathepsin B and D...
- Activation of cathepsins B and L in mouse lymphosarcoma tissue under the effect of cyclophosphamide is associated with apoptosis induction and infiltration by mononuclear phagocytesS Ya Zhanaeva
Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia
Bull Exp Biol Med 156:86-90. 2013..It seems that the increase in cathepsins B and L activities in LS tissues was caused by cyclophosphamide induction of apoptosis and depended on the level of tumor cell infiltration with mononuclear phagocytes. ..
- Chlamydia muridarum infection of macrophages elicits bactericidal nitric oxide production via reactive oxygen species and cathepsin BKrithika Rajaram
Department of Biology, Indiana University, Bloomington, Indiana, USA
Infect Immun 83:3164-75. 2015..A hydroxyl radical scavenger and inhibitors of inducible nitric oxide synthase (iNOS) and cathepsin B also reversed chlamydial killing...
- Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune EncephalomyelitisEuan Ramsay Orr Allan
Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Alberta, Canada
PLoS ONE 10:e0128945. 2015..MOG) was efficiently processed and presented by macrophages to CD4+ T cells in the individual absence of cathepsin B, S or L...
- Cysteine cathepsins are essential in lysosomal degradation of α-synucleinRyan P McGlinchey
Laboratory of Molecular Biophysics, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
Proc Natl Acad Sci U S A 112:9322-7. 2015..brain and liver lysosomal extracts and individual human cathepsins demonstrate a direct involvement of cysteine cathepsin B (CtsB) and L (CtsL). Both CtsB and CtsL cleave α-syn within its amyloid region and circumvent fibril formation...
- The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/MacrophageJunjun Ni
Department of Aging Science and Pharmacology, Faculty of Dental Science, and
J Neurosci 35:12488-501. 2015Proteinase cascades are part of the basic machinery of neuronal death pathways. Neuronal cathepsin B (CatB), a typical cysteine lysosomal protease, plays a critical role in neuronal death through lysosomal leakage or excessive autophagy...
- IGF-1 promotes the growth and metastasis of hepatocellular carcinoma via the inhibition of proteasome-mediated cathepsin B degradationTian Lei
Tian Lei, Department of Gastroenterology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China
World J Gastroenterol 21:10137-49. 2015..To investigate the molecular mechanisms of the high IGF-1 level linking diabetes and cancers, which is a risk factor...
- NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitisPrajwal Gurung
Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
Proc Natl Acad Sci U S A 113:4452-7. 2016..In conclusion, our studies have uncovered the combined actions of the NLRP3 inflammasome and caspase 8 leading to IL-1β maturation and the directionality of IL-1β in driving disease inPstpip2(cmo)mice. ..
- Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infectionXiaopeng Qi
Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
J Exp Med 213:2081-97. 2016..In this study, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and autophagy...
- P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseasesGloria Lopez-Castejon
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
J Immunol 185:2611-9. 2010..bone marrow-derived macrophages and found that ATP induced rapid release of the lysosomal cysteine proteases cathepsin B, K, L, and S and that was independent of the presence of the proinflammatory cytokines IL-1beta and IL-18...
- Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malariaParisa Kalantari
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Rep 6:196-210. 2014..Finally, infected erythrocytes activated both the NLRP3 and AIM2 inflammasomes. These observations suggest that Hz and DNA work together to induce systemic inflammation during malaria. ..
- Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7Pieter Steenhuis
Department of Biochemistry, Children s Hospital, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
Biochim Biophys Acta 1822:1617-28. 2012..Our findings suggest that CLN7 is inactivated by proteolytic cleavage and that enhanced CLN7 proteolysis caused by missense mutations in selected luminal loops is associated with disease...
- Cathepsin B controls the persistence of memory CD8+ T lymphocytesSusan M Byrne
Section of Immunobiology, Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom
J Immunol 189:1133-43. 2012..Spi2A protected memory cells from lysosomal breakdown by inhibiting cathepsin B. The impaired maintenance of Spi2A-deficient memory CD8(+) T cells was rescued by concomitant cathepsin B ..
- Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor proteinChao Wang
Gladstone Institute of Neurological Diseases, San Francisco, California 94158, USA
J Biol Chem 287:39834-41. 2012..Previously, we showed that the cysteine protease cathepsin B (CatB) degrades Aβ, most likely by C-terminal truncation, in mice expressing human amyloid precursor protein ..
- Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradomeStefan Tholen
Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany
Mol Cell Proteomics 12:611-25. 2013..In stark contrast, mice deficient in cathepsin B (Ctsb) do not display an overt skin phenotype...
- Cathepsin B & L are not required for ebola virus replicationAndrea Marzi
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
PLoS Negl Trop Dis 6:e1923. 2012..Later in this pathway endosomal acidification activates the cysteine proteases Cathepsin B and L (CatB, CatL), which have been shown to cleave ZEBOV-GP leading to subsequent exposure of the putative ..
- Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsinsArvind Dev
Center of Excellence in Stem Cell Biology and Regenerative Medicine COBRE, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
J Exp Med 210:225-32. 2013..Spi2A defects were ameliorated by cathepsin-B/L inhibition, and by genetic co-deletion of lysosomal cathepsin B. Pharmacological inhibition of cathepsin B/L enhanced EPO-induced red cell formation in normal mice...
- Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocystA Dardik
Department of Biology, University of Pennsylvania, Philadelphia 19104
Dev Biol 154:396-409. 1992..The co-localization of TGF-alpha and functional EGFRs to the ICM and polar TE suggests potential autocrine, juxtacrine, and paracrine roles for TGF-alpha in blastocyst development...
- The structure of the mouse cathepsin B gene and its putative promoterF Qian
Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637
DNA Cell Biol 10:159-68. 1991The mouse cathepsin B gene and its flanking regions were cloned and characterized. The gene contains 10 exons and 9 introns spanning about 20 kb...
- Gene structure of mouse cathepsin BM Ferrara
Unité de Recherches sur l Expression des Protéases, SRV Theix, Institut National de la Recherche Agronomique, Ceyrat, France
FEBS Lett 273:195-9. 1990The structure of a genomic DNA fragment encoding mouse cathepsin B was characterized. The genomic insert spans 15 kbp and contains 9 exons encoding the 339 amino acid residues of mouse preprocathepsin B...
- Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAsS J Chan
Proc Natl Acad Sci U S A 83:7721-5. 1986b>Cathepsin B is a lysosomal thiol proteinase that may have additional extralysosomal functions...
- Multiple leader sequences for mouse cathepsin B mRNA?H Rhaissi
Unité Expression des Protéases Lysosomales, INRA Theix, Saint Genes Champanelle, France
Biochimie 75:899-904. 1993We previously described the gene structure of murine cathepsin B. Our results suggested that the 5'-untranslated region (leader) is interrupted by a large intron. The second exon (exon-2) contains the translation initiation site...
- Gene trapping in differentiating cell lines: regulation of the lysosomal protease cathepsin B in skeletal myoblast growth and fusionJ A Gogos
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Cell Biol 134:837-47. 1996..The first gene we have identified with this strategy is the lysosomal cysteine protease cathepsin B. Expression from the trapped allele is upregulated during early myoblast fusion and downregulated in myotubes...
- Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brainN Malgaretti
Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute HSR, I 20132 Milan, Italy
J Biol Chem 272:17632-9. 1997....
- The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentationS Afonso
Department of Cell, Developmental and Neurobiology, Nelson Labs, Busch Campus, Rutgers University, Piscataway, NJ 08855, USA
Development 124:3415-25. 1997..Northern blots showed that trophoblast expressed cathepsin B throughout the invasive period (days 5.5-10.5)...
- Cathepsin expression during skeletal developmentM Soderstrom
Skeletal Research Program, Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
Biochim Biophys Acta 1446:35-46. 1999..a panel of total RNAs isolated from 16-19 different human and mouse tissues revealed the presence of mRNAs for cathepsin B, H, K, L and S in most tissues, but each with a distinct profile...
- Expression of cysteine proteases in extraembryonic tissues during mouse embryogenesisK Sol-Church
Department of Research, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, Delaware, 19803, USA
Arch Biochem Biophys 372:375-81. 1999The expression of cathepsin B- and L-specific mRNAs as well as active forms of the enzymes was determined in mouse placenta and visceral yolk sac from 7.5 through 17...
- Expression of cathepsin proteinases by mouse trophoblast in vivo and in vitroS Afonso
Department of Cell Biology and Neuroscience, Nelson Labs, Rutgers University, Piscataway, NJ 08855, USA
Dev Dyn 216:374-84. 1999....
- Molecular characterization of putative yolk processing enzymes and their expression during oogenesis and embryogenesis in rainbow trout (Oncorhynchus mykiss)J Y Kwon
School of Biological Sciences, University of Exeter, Exeter EX4 4PS, United Kingdom
Biol Reprod 65:1701-9. 2001..In this study we cloned three putative yolk processing enzymes; specifically, cathepsin B and L, and lipoprotein lipase (LPL), from the rainbow trout ovary and determined their patterns of gene ..
- Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasisAli Canbay
Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
J Clin Invest 112:152-9. 2003Although a lysosomal, cathepsin B-dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this pathway to tissue damage remains unclear...
- Up-regulation of cathepsin B and cathepsin L activities in scrapie-infected mouse Neuro2a cellsYonghua Zhang
Department of Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
J Gen Virol 84:2279-83. 2003..We hypothesize that lysosomal proteases may be involved in a 'second autocatalytic loop' of PrP(Sc) formation, acting in concert with the well-known autocatalytic enhancement of PrP conversion in the presence of PrP(Sc)...
- Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)Megan K Houseweart
Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305, USA
J Neurobiol 56:315-27. 2003..L or S from cystatin B-deficient mice did not ameliorate any aspect of the EPM1 phenotype, removal of cathepsin B resulted in a 36-89% reduction in the amount of cerebellar granule cell apoptosis depending on mouse age...
- Cathepsin B Is Inhibited in Mutant Cells Selected during Persistent Reovirus InfectionDaniel H Ebert
Departments of Microbiology and Immunology and Pediatrics and Elizabeth B Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
J Biol Chem 279:3837-51. 2004..contrast to parental L cells, mutant LX cells harbor defects that interfere with the maturation and activity of cathepsin B and cathepsin L but not cathepsin H...
- Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivoLianjun Shen
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Immunity 21:155-65. 2004..Therefore, cathepsin S plays a major role in generating presented peptides for the vacuolar pathway of crosspresentation, and this mechanism is active in vivo...
- Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injuryE S Baskin-Bey
Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA
Am J Physiol Gastrointest Liver Physiol 288:G396-402. 2005..Wild-type and cathepsin B-knockout (Ctsb(-/-)) mice were fed the methionine/choline-deficient (MCD) diet for 2 wk to induce hepatic ..
- Bone microenvironment modulates expression and activity of cathepsin B in prostate cancerIzabela Podgorski
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Neoplasia 7:207-23. 2005..Because secretion of the cysteine protease cathepsin B is increased in human breast fibroblasts grown on collagen I gels, we analyzed cathepsin B levels and secretion ..
- A role for cathepsin E in the processing of mast-cell carboxypeptidase AFrida Henningsson
Swedish University of Agricultural Sciences, Department of Molecular Biosciences, The Biomedical Centre, Box 575, 751 23 Uppsala, Sweden
J Cell Sci 118:2035-42. 2005..Taken together, our results indicate that cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and that it has a role in the processing of procarboxypeptidase A into active protease...
- Cathepsin B inactivation attenuates the apoptotic injury induced by ischemia/reperfusion of mouse liverZ Ben-Ari
Liver Institute and Department of Medicine D, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
Apoptosis 10:1261-9. 2005..Recently, it was demonstrated that the release of cathepsin B, a cysteine protease, from the cytosol in liver injury induces mitochondrial release of cytochrome c and the ..
- Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long boneVincent Everts
Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam, Amsterdam, The Netherlands
J Bone Miner Res 21:1399-408. 2006..The results support the notion that osteoclasts from different bone sites use different enzymes to degrade the collagenous bone matrix...
- Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's diseaseSarah Mueller-Steiner
Gladstone Institute of Neurological Disease, University of California, San Francisco, 1650 Owens Street, 94158, USA
Neuron 51:703-14. 2006..The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD brains and has been suspected to increase Abeta production...
- Cathepsin protease activity modulates amyloid load in extracerebral amyloidosisC Rocken
Institute of Pathology, Charite University Hospital, Berlin, Germany
J Pathol 210:478-87. 2006..CathL was identified as an amyloid-promoting and CathK as an amyloid-retarding cysteine protease. CathB may only modulate the primary structure of the amyloid peptide without affecting amyloid load...
- Induced expression of cathepsins and cystatin C in a murine model of demyelinationJianmei Ma
Department of Anatomy, Dalian Medical University, Dalian, Liaoning, China
Neurochem Res 32:311-20. 2007..We propose that in MS, remyelination may be impaired by increasing activity of cathepsins inadequately controlled by cystatin C...
- Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expressionPatrick Geraghty
Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
J Immunol 178:5871-8. 2007..NE exposure resulted in macrophages, producing significantly greater amounts of cathepsin B and latent and active MMP-2...
- Proteolytic disassembly is a critical determinant for reovirus oncolysisTommy Alain
Department of Medical Sciences, Clark Smith Integrative Brain Tumor Research Center, Southern Alberta Cancer Research Institute, University of Calgary, Alberta, Canada
Mol Ther 15:1512-21. 2007..We find that the level of active cathepsin B and L is increased in tumors and that disassembly-restrictive glioma cells support reovirus oncolysis when ..
- Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient miceO Vasiljeva
Institut für Molekulare Medizin und Zellforschung, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
Oncogene 27:4191-9. 2008Expression levels of the papain-like cysteine protease cathepsin B (Ctsb) have been positively correlated with mammary tumour progression and metastasis; however, its roles in the hallmark processes of malignant growth remain poorly ..
- Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's diseaseBinggui Sun
Gladstone Institute of Neurological Disease, University of California San Francisco, San Francisco, CA 94158, USA
Neuron 60:247-57. 2008..Cystatin C (CysC, CST3) is an endogenous inhibitor of cysteine proteases, including cathepsin B (CatB), a recently discovered Abeta-degrading enzyme...
- Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblastsChun Tu
Eppley Institute for Research in Cancer and Allied Diseases, and UNMC Eppley Cancer Center, Omaha, NE 68198 6805, USA
Cancer Res 68:9147-56. 2008..Using inhibitors and shRNA-mediated depletion, we show that cathepsin B participates in podosomes-mediated focal matrix degradation and invasion in v-Src-transformed fibroblasts...
- Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phasesAnna Vreemann
School of Engineering and Science, Jacobs University Bremen, Campus Ring 6, D 28759 Bremen, Germany
Biol Chem 390:481-92. 2009..of different intestine segments by immunofluorescence microscopy provided evidence for a local release of cathepsin B from cells of individual gut sections shortly after traumatic injury...
- Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defenceOlaf Gross
III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
Nature 459:433-6. 2009..Thus, our results demonstrate the molecular basis for IL-1beta production after fungal infection and identify a crucial function for the Nlrp3 inflammasome in mammalian host defence in vivo...
- Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasomeJoseph A Duncan
Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Immunol 182:6460-9. 2009..Additionally, N. gonorrhoeae activates the cysteine protease cathepsin B as measured by the breakdown of a cathepsin B substrate...
- Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microgliaKayo Terada
Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
Glia 58:114-24. 2010b>Cathepsin B (CB) is a cysteine lysosomal protease implicated in a number of inflammatory diseases...
- Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesisElizabeth M Johnson
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Virol 83:9630-40. 2009..Mammalian reoviruses utilize cathepsins B (Ctsb), L (Ctsl), and S (Ctss) for disassembly of the virus outer capsid and activation of the membrane penetration ..
- Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fateDavid R C Natale
Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, Calgary, AB, Canada T2N 4N1
Dev Biol 335:120-31. 2009..These results suggest that Activin rather than TGF-beta (or Nodal) acts directly on TS cells influencing both TS cell maintenance and cell fate, depending on whether the cells are also exposed to FGF4...
- Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasmSoon Duck Ha
Department of Microbiology and Immunology, Siebens Drake Research Institute, University of Western Ontario, London, Ontario N6G2V4, Canada
J Biol Chem 285:2120-9. 2010..We found that the cytoplasmic delivery of LF by ANTXR2 was mediated by cathepsin B (CTSB) and required lysosomal fusion with LeTx-containing endosomes...
- IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasionVasilena Gocheva
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genes Dev 24:241-55. 2010..Together, these data establish IL-4 as an important regulator, and cathepsin proteases as critical mediators, of the cancer-promoting functions of TAMs...
- Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in miceLisa Sevenich
Institute of Molecular Medicine and Cell Research Faculty of Biology, Albert Ludwigs University, Freiburg D 79104, Germany
Proc Natl Acad Sci U S A 107:2497-502. 2010The lysosomal cysteine proteases cathepsin B (Ctsb) and cathepsin Z (Ctsz, also called cathepsin X/P) have been implicated in cancer pathogenesis. Compensation of Ctsb by Ctsz in Ctsb (-/-) mice has been suggested...
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsPeter Duewell
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 464:1357-61. 2010..induce acute inflammation, which is impaired in mice deficient in components of the NLRP3 inflammasome, cathepsin B, cathepsin L or IL-1 molecules...
- Cathepsin B-dependent motor neuron death after nerve injury in the adult mouseLi Sun
Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
Biochem Biophys Res Commun 399:391-5. 2010..b>Cathepsin B (CB), a typical cysteine lysosomal protease, has been implicated in three major morphologically distinct ..
- Missorting of cathepsin B into the secretory compartment of CI-MPR/IGFII-deficient mice does not induce spontaneous trypsinogen activation but leads to enhanced trypsin activity during experimental pancreatitis--without affecting disease severityT Meister
Department of Medicine B, Westfalische Wilhelms Universitat, Munster, Germany
J Physiol Pharmacol 61:565-75. 2010The lysosomal protease cathepsin B is thought to play a crucial role in the intracellular activation cascade of digestive proteases and in the initiation of acute pancreatitis...
- Localization of cathepsins D and B at the maternal-fetal interface and the invasiveness of the trophoblast during the postimplantation period in the mouseA M Amarante-Paffaro
Laboratory of Cytochemistry and Immunocytochemistry, Institute of Biology, University of Campinas, Campinas, Brazil
Cells Tissues Organs 193:417-25. 2011..Cathepsin D, but not cathepsin B, was also detected ultrastructurally in extracellular compartments surrounded by processes of the invading ..
- Isolation of a cathepsin B-encoding cDNA from murine osteogenic cellsC Freimert
GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Abteilung für Molekulare Zellpathologie, Neuherberg F R G
Gene 103:259-61. 1991b>Cathepsin B-encoding cDNA (CTSB) clones have been isolated from a lambda gt10 library of a murine osteosarcoma by differential screening during a search for genes which are typically expressed during osteogenic differentiation in mouse ..
- Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potentialF Qian
Howard Hughes Medical Institute, University of Chicago, Illinois 60637
Biochem Biophys Res Commun 202:429-36. 1994The highly metastatic B16a melanoma has been shown to express higher levels of cathepsin B (CB) mRNA when compared to the less metastatic variants, B16-F1 and B16-F10, and with normal mouse tissues...
- Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulationKithiganahalli N Balaji
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
J Exp Med 196:493-503. 2002..The potent activity of the impermeant, highly cathepsin B-specific membrane inhibitors CA074 and NS-196 strongly implicates extracellular cathepsin B...
- Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemiaAlexandra Benchoua
Institut National de la Sante et de la Recherche Medicale, Universite Paris Val de Marne, Crétoil, France
J Cereb Blood Flow Metab 24:1272-9. 2004..This study investigated the existence of a cross-talk between cathepsin B and proinflammatory caspases in stroke-induced cell death, as recently suggested by in vitro data...
- Oxidized Lipoproteins in NeurodegenerationMark Kindy; Fiscal Year: 2004..These studies should provide insights into the normal function of HDL and SR in the CNS and in the pathogenesis of AD. ..
- Neprilysin and Abeta-degradation in Alzheimer's diseaseMark Kindy; Fiscal Year: 2005..The results generated from this study will help us to understand how Abeta peptides are degraded and may provide a unique therapeutic window for the treatment of AD. ..
- Pesticides, Paraoxonase and Alzheimer's DiseaseMark S Kindy; Fiscal Year: 2010..The focus of this proposal is to understand the function of organophosphates (OPs as symbolic ETs) and interrelationship between ETs and paraoxonase (PON- 1) in oxidative stress and inflammation associated with AD. ..
- Proteomics/Genomics of Opiate Analgesia and AddictionVivian Hook; Fiscal Year: 2004..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
- INTEGRATED DNA SEQUENCING SYSTEMVivian Hook; Fiscal Year: 2002..abstract_text> ..
- Cathepsin B and cystatin C in AD-related neuronal damageLi Gan; Fiscal Year: 2005..We have shown that cathepsin B (CatB) released from Abeta-stimulated microglial cells plays a critical role in microglial-mediated neuronal ..
- Serpin Protease Inhibitors & Opioid NeuropeptidesVivian Hook; Fiscal Year: 2006..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
- POMC Processing and Beta-Endorphine-Related Opioid PeptidesVivian Y H Hook; Fiscal Year: 2010..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
- BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDESVivian Hook; Fiscal Year: 2009..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..