Genomes and Genes
Gene Symbol: Csf2
Description: colony stimulating factor 2 (granulocyte-macrophage)
Alias: Csfgm, GMCSF, Gm-CSf, MGI-IGM, granulocyte-macrophage colony-stimulating factor, CSF, colony-stimulating factor, granulocyte-macrophage colony stimulating factor 2, put. GM-CSF
Publications164 found, 100 shown here
- Granulocyte macrophage colony-stimulating factor is required for cytokine induction by a highly 6-branched 1,3-β-D-glucan from Aureobasidium pullulans in mouse-derived splenocytesRui Tada
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
Immunopharmacol Immunotoxicol 33:302-8. 2011..of cytokines by AP-FBG was dependent on the existence of a granulocyte macrophage colony-stimulating factor (GM-CSF); this is similar way to be a typical 1,3-β-D-glucan from Sparassis crispa (SCG), which is a 1,3-β-D-..
- Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1Rajinder P Parti
Department of Pediatrics, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 42:415-23. 2010..in unprimed alveolar macrophages and after priming with granulocyte macrophage colony-stimulating factor (GM-CSF), which regulates alveolar macrophage maturation...
- Hypoxia-inducible factor-2α regulates GM-CSF-derived soluble vascular endothelial growth factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesisJulie M Roda
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA
J Immunol 187:1970-6. 2011..We have recently demonstrated that macrophages stimulated with GM-CSF at low O(2) secrete high levels of a soluble form of the VEGF receptor 1 (sVEGFR-1), which neutralizes VEGF and ..
- Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSFShinya Dohgu
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
J Neuroinflammation 8:167. 2011..g/mL, 4 hr) selectively increased interleukin (IL)-6 and granulocyte-macrophage colony-stimulating factor (GM-CSF) release from BMECs...
- SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritisPeter K K Wong
Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Clin Invest 116:1571-81. 2006..These features were most likely due to increased production of and enhanced responsiveness to G-CSF and IL-6 during arthritis in these mice...
- HNF-1 alpha and HNF-1 beta expression in mouse intestinal cryptsM S Serfas
Department of Genetics, University of Illinois College of Medicine, Chicago 60612
Am J Physiol 265:G506-13. 1993..Although HNF-1 is necessary for transcription of the AFP gene, other factors must be involved in eliciting the cell type-specific pattern of AFP expression in the intestine...
- cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2M Shindo
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Biochem Biophys Res Commun 244:285-92. 1998..Interspecific backcross mapping revealed that Ark1 is located in a distal region of mouse chromosome 2, while Ark2 is located in a central region of mouse chromosome 11...
- Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouseTakaaki Sugimoto
Department of Surgery, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, 663 8501, Japan
J Exp Med 199:535-45. 2004..Thus, Ag and IL-18 stimulate memory Th1 cells to induce severe airway inflammation and AHR in the naive host...
- Differential use of CARD9 by dectin-1 in macrophages and dendritic cellsHelen S Goodridge
Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Immunol 182:1146-54. 2009..However, priming of bone marrow-derived macrophages with GM-CSF or IFN-gamma permits Dectin-1-CARD9-mediated TNF-alpha induction...
- In vitro effector activity of Pneumocystis murina-specific T-cytotoxic-1 CD8+ T cells: role of granulocyte-macrophage colony-stimulating factorFlorencia McAllister
Children s Hospital of Pittsburgh, Department of Pediatrics, Suite 3765, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
Infect Immun 73:7450-7. 2005..CD8+ T cells secreted higher levels of IFN-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) and lower levels of interleukin-4 (IL-4), IL-5, IL-10, and IL-13 than Tc2 CD8+ T cells when stimulated with P...
- Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell functionDonald Cheatem
Department of Microbiology and Immunology MC790, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Clin Immunol 131:260-70. 2009..In this study, we used GM-CSF and Flt3-L to modulate DC function in NOD mice and observed the effects on T1D development...
- Granulocyte-macrophage colony-stimulating factor corrects macrophage deficiencies, but not osteopetrosis, in the colony-stimulating factor-1-deficient op/op mouseW Wiktor-Jedrzejczak
Department of Immunology, Central Clinical Hospital, Military School of Medicine, Warsaw, Poland
Endocrinology 134:1932-5. 1994The op mutation in the mouse is in the coding region of the colony-stimulating factor-1 (CSF-1) gene, prevents formation of biologically active factor, and, thus, results in generalized macrophage deficiency and, in osteopetrosis, ..
- Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4Saroj K Basak
Division of Pulmonary and Critical Care, Department of Medicine, UCLA School of Medicine, Los Angeles 90095 1690, USA
Blood 99:2869-79. 2002..The combination of recombinant granulocyte macrophage-colony-stimulating factor (rGM-CSF) and recombinant interleukin-4 (rIL-4) provides an important stimulus for generating DCs from murine bone marrow ..
- Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4Stacey A Ritz
Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, Hamilton, Ontario, Canada
Am J Respir Cell Mol Biol 27:428-35. 2002..whether IL-4 is necessary for Th2-polarized responses during granulocyte macrophage colony-stimulating factor (GM-CSF)-driven respiratory mucosal sensitization...
- IL-3 and granulocyte-macrophage colony-stimulating factor strongly induce Ig secretion by sort-purified murine B cell activated through the membrane Ig, but not the CD40, signaling pathwayC M Snapper
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 154:5842-50. 1995..We show that either IL-3 or granulocyte-macrophage CSF (GM-CSF) stimulates 10- to 50-fold enhancements in IgM secretion by sort-purified B cells treated with alpha delta-..
- Bone marrow and splenic granulocyte-macrophage colony-stimulating factor and transforming growth factor-beta mRNA levels in irradiated miceC M Chang
Department of Experimental Hematology, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Blood 86:2130-6. 1995..radiation exposure on endogenous bone marrow (BM) and splenic granulocyte-macrophage colony-stimulating factor (GM-CSF) and transforming growth factor-beta (TGF-beta) mRNA levels were assayed in B6D2F1 female mice...
- Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasisG Dranoff
Whitehead Institute for Biomedical Research, Cambridge, MA
Science 264:713-6. 1994The in vivo function of murine granulocyte-macrophage colony-stimulating factor (GM-CSF) was investigated in mice, carrying a null allele of the GM-CSF gene, that were generated by gene targeting techniques in embryonic stem cells...
- Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in miceG Tiegs
Department of Biochemical Pharmacology, Faculty of Biology, University of Konstanz, Germany
J Clin Invest 93:2616-22. 1994GM-CSF is known to prime leukocytes for inflammatory stimuli in vitro. The objective of this study was to investigate the role of GM-CSF in vivo in a systemic inflammatory reaction syndrome...
- Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathologyE Stanley
Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Victoria, Australia
Proc Natl Acad Sci U S A 91:5592-6. 1994Mice homozygous for a disrupted granulocyte/macrophage colony-stimulating factor (GM-CSF) gene develop normally and show no major perturbation of hematopoiesis up to 12 weeks of age...
- Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient miceJ A Huffman
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Clin Invest 97:649-55. 1996Mutation of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene by homologous recombination caused alveolar proteinosis in mice...
- T cell functions in granulocyte/macrophage colony-stimulating factor deficient miceH Wada
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 94:12557-61. 1997Immunological functions were analyzed in mice lacking granulocyte/macrophage colony-stimulating factor (GM-CSF)...
- Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected miceY Zhan
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia
Blood 91:863-9. 1998The in vivo roles of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte (G)-CSF were studied in factor-deficient gene-targeted knockout mice infected with the facultative intracellular bacterium Listeria ..
- Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient miceI K Campbell
Department of Medicine, Inflammation Research Center, University of Melbourne, Victoria, Australia
J Immunol 161:3639-44. 1998The involvement of granulocyte-macrophage CSF (GM-CSF) in collagen-induced arthritis (CIA) was examined using GM-CSF-deficient mice...
- GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infectionA M Levine
Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
J Clin Invest 103:563-9. 1999Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-targeted mice (GM-/-) cleared group B streptococcus (GBS) from the lungs more slowly than wild-type mice...
- Distinct changes in pulmonary surfactant homeostasis in common beta-chain- and GM-CSF-deficient miceJ A Reed
Children s Hospital Medical Center, Cincinnati, Ohio 43229 3039, USA
Am J Physiol Lung Cell Mol Physiol 278:L1164-71. 2000..alveolar proteinosis (PAP) is caused by inactivation of either granulocyte-macrophage colony-stimulating factor (GM-CSF) or GM receptor common beta-chain (beta(c)) genes in mice [GM(-/-), beta(c)(-/-)], demonstrating a critical role of ..
- GM-CSF regulates protein and lipid catabolism by alveolar macrophagesM Yoshida
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 280:L379-86. 2001..DPPC) was assessed in alveolar macrophages isolated from granulocyte-macrophage colony-stimulated factor (GM-CSF) gene-targeted [GM(-/-)] mice, wild-type mice, and GM(-/-) mice expressing GM-CSF under control of the SP-C ..
- Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosisJ L McQualter
Neuroimmunology Laboratory, Department of Biochemistry, La Trobe University, Victoria 3086, Australia
J Exp Med 194:873-82. 2001..The hematopoietic growth factor, granulocyte macrophage colony-stimulating factor (GM-CSF), is considered to play a central role in maintaining chronic inflammation...
- Impaired functional activity of alveolar macrophages from GM-CSF-deficient miceR Paine
Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Am J Physiol Lung Cell Mol Physiol 281:L1210-8. 2001We hypothesized that pulmonary granulocyte-macrophage colony-stimulating factor (GM-CSF) is critically involved in determining the functional capabilities of alveolar macrophages (AM) for host defense...
- GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1Y Shibata
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Immunity 15:557-67. 2001GM-CSF gene targeted (GM(-/-)) mice are susceptible to respiratory infections and develop alveolar proteinosis due to defects in innate immune function and surfactant catabolism in alveolar macrophages (AMs), respectively...
- Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentationFabio Re
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 169:2264-73. 2002Neonatal microglial cells respond to GM-CSF and M-CSF by acquiring different morphologies and phenotypes...
- Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivoSteven Bozinovski
Arthritis and Inflammation Research Center, Department of Medicine, Cooperative Research Center CRC for Chronic Inflammatory Diseases, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia
J Biol Chem 277:42808-14. 2002..the role of Akt and Erk1/2 as LPS intensely stimulates granulocyte/macrophage-colony-stimulating factor (GM-CSF) release, and neutralizing GM-CSF profoundly suppressed LPS-induced inflammation, suppressed expression and ..
- Deficiencies of GM-CSF and interferon gamma link inflammation and cancerThomas Enzler
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 197:1213-9. 2003..We report that aged granulocyte-macrophage colony stimulating factor (GM-CSF)-deficient mice develop a systemic lupus erythematosis (SLE)-like disorder associated with the ..
- GM-CSF BiologyJohn A Hamilton
Department of Medicine, Arthritis and Inflammation Research Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville 3010 Vic, Australia
Growth Factors 22:225-31. 2004Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally defined by its ability to generate in vitro granulocyte and macrophage colonies from bone marrow precursor cells...
- GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirementsKate H Brettingham-Moore
Discipline of Biochemistry, University of Tasmania Private Bag 58, Hobart 7001, Tasmania, Australia
Nucleic Acids Res 33:225-34. 2005Granulocyte-macrophage colony stimulating factor (GM-CSF) plays a key role in myeloid cell function and is rapidly and transiently expressed in T cells in response to immune or inflammatory stimuli...
- Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproductionSally A Litherland
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Immunol 175:4561-5. 2005..NODC11), or diabetes-resistant C57L (NOD.LC11) loci on chromosome 11. These intervals contain the gene for GM-CSF (Csf2; 53.8 Mb) and those for STAT3, STAT5A, and STAT5B (Stat3, Stat5a, and Stat5b; 100.4-100.6 Mb)...
- Elevated gelatinase activity in pulmonary alveolar proteinosis: role of macrophage-colony stimulating factorTracey L Bonfield
Department of Pulmonary, Allergy and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195 5038, USA
J Leukoc Biol 79:133-9. 2006Pulmonary alveolar proteinosis (PAP) is an anti-granulocyte macrophage-colony stimulating factor (GM-CSF) autoimmune disease resulting in the accumulation of phospholipids in the alveoli...
- GM-CSF action in the CNS decreases food intake and body weightJacquelyn A Reed
University of Cincinnati, Cincinnati, Ohio, USA
J Clin Invest 115:3035-44. 2005..The present work tested a role for the proinflammatory cytokine GM-CSF. Central but not peripheral administration of GM-CSF to adult rats significantly decreased food intake and body ..
- GM-CSF deficiency reduces macrophage PPAR-gamma expression and aggravates atherosclerosis in ApoE-deficient miceMichael Ditiatkovski
Cell Biology Laboratory, Monash University, Melbourne, Victoria, 8008, Australia
Arterioscler Thromb Vasc Biol 26:2337-44. 2006Granulocyte-macrophage colony-stimulating factor (GM-CSF) is expressed in atherosclerotic lesions but its significance for lesion development is unknown...
- GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPSPierre Yves Berclaz
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 36:114-21. 2007..Because granulocyte macrophage colony-stimulating factor (GM-CSF)-deficient (GM(-/-)) mice are hyporesponsive to LPS, we evaluated the role of GM-CSF in TLR-4 signaling in AMs...
- Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogenyJelena S Bezbradica
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Immunity 25:487-97. 2006..We discovered that granulocyte-macrophage colony-stimulating factor (Csf-2)-deficient mice developed iNKT cells that failed to respond to the model antigen alpha-galactosylceramide because ..
- Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesionsZory Shaposhnik
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Arterioscler Thromb Vasc Biol 27:621-7. 2007..Based primarily on previous in vitro studies, we hypothesized that granulocyte macrophage colony-stimulating factor (GM-CSF)-deficient mice would have decreased dendritic cells in lesions.
- GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitisEugene D Ponomarev
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
J Immunol 178:39-48. 2007..autoimmune disease believed to be triggered by T cells secreting Th1-specific proinflammatory cytokines, such as GM-CSF. In the animal model of MS, experimental autoimmune encephalomyelitis (EAE), Th1 but not Th2 cells have been shown ..
- Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammationAndrew J Fleetwood
Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
J Immunol 178:5245-52. 2007GM-CSF and M-CSF (CSF-1) can enhance macrophage lineage numbers as well as modulate their differentiation and function...
- Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitisMargaret L Hibbs
Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, and Department of Medicine, University of Melbourne, Parkville, Australia
J Immunol 178:6435-43. 2007To assess the combined role of G-CSF, GM-CSF, and M-CSF in myeloid cell production, mice deficient in all three myeloid CSFs were generated (G-/-GM-/-M-/- mice)...
- ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosisMary Jane Thomassen
Program in Lung Cell Biology and Translational Research, Division of Pulmonary and Critical Care Medicine, East Carolina University, Greenville, NC, USA
J Lipid Res 48:2762-8. 2007..Neutralizing autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) are also present, resulting in virtual GM-CSF deficiency...
- Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammationYung Chang Su
Immunology and Inflammation Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
J Immunol 180:2600-7. 2008GM-CSF plays an important role in inflammation by promoting the production, activation, and survival of granulocytes and macrophages...
- Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factorTracey L Bonfield
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44109, USA
J Immunol 181:235-42. 2008Macrophage CSF (M-CSF) regulates monocyte differentiation, activation, and foam cell formation. We have observed that it is elevated in human pulmonary alveolar proteinosis (PAP) and in the GM-CSF knockout mouse, a murine model for PAP...
- GM-CSF enhances a CpG-independent pathway of neutrophil activation triggered by bacterial DNAJuan I Fuxman Bass
Departamento de Inmunologia, Instituto de Investigaciones Hematológicas e Instituto de Estudios Oncológicos Fundación Maissa Academia Nacional de Medicina, Buenos Aires, Argentina
Mol Immunol 46:37-44. 2008..In this study we determined that GM-CSF enhances the activation of neutrophils by bacterial DNA...
- The role of GM-CSF in adipose tissue inflammationDong Hoon Kim
Department of Psychiartry, University of Cincinnati, Cincinnati, OH, USA
Am J Physiol Endocrinol Metab 295:E1038-46. 2008Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a proinflammatory cytokine that has a central action to reduce food intake and body weight...
- GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survivalIvo Sonderegger
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, 8952 Zurich, Switzerland
J Exp Med 205:2281-94. 2008Granulocyte macrophage-colony stimulating factor (GM-CSF) is critically involved in development of organ-related autoimmune inflammatory diseases including experimental allergic encephalitis and collagen-induced arthritis...
- Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating diseaseIrah L King
Interdepartmental Graduate Program in Neuroscience, School of Medicine and Dentistry, University of Rochester, NY, USA
Blood 113:3190-7. 2009....
- GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesionsSu Ning Zhu
Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
J Exp Med 206:2141-9. 2009..Systemic injection of granulocyte/macrophage colony-stimulating factor (GM-CSF) markedly increased cell proliferation in early lesions, whereas function-blocking anti-GM-CSF antibody inhibited ..
- The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesisAkiko Kimura
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD, USA
Blood 114:4721-8. 2009..Granulocyte macrophage-colony stimulating factor (GM-CSF) controls homeostatic and emergency development of granulocytes...
- Restoration of PPARγ reverses lipid accumulation in alveolar macrophages of GM-CSF knockout miceAnagha Malur
East Carolina Univ, Greenville, NC 27834, USA
Am J Physiol Lung Cell Mol Physiol 300:L73-80. 2011..is a lung disease characterized by a deficiency of functional granulocyte macrophage colony-stimulating factor (GM-CSF) resulting in surfactant accumulation and lipid-engorged alveolar macrophages...
- Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lungTim Willinger
Department of Immunobiology, The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 108:2390-5. 2011..To overcome this, we generated human IL-3/GM-CSF knock-in (hIL-3/GM-CSF KI) mice...
- Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cellsIan K Campbell
Reid Rheumatology Laboratory, Division of Inflammation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
J Immunol 186:5468-77. 2011..We evaluated CD4 T cell function in Nfkb1(-/-) mice and found increased apoptosis and selectively reduced GM-CSF production. Apoptosis was blocked by expression of a Bcl-2 transgene without restoring a disease response...
- The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSFMohamed El-Behi
Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Nat Immunol 12:568-75. 2011..Here we found that IL-23 induced production of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in T(H)17 cells and that GM-CSF had an essential role in their encephalitogenicity...
- RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammationLaura Codarri
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
Nat Immunol 12:560-7. 2011..Here we report that interleukin 23 (IL-23) and the transcription factor RORγt drove expression of the cytokine GM-CSF in helper T cells, whereas IL-12, interferon-γ (IFN-γ) and IL-27 acted as negative regulators...
- Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cellsJohn R Lukens
Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Immunol 188:3107-15. 2012Recent findings have demonstrated an indispensable role for GM-CSF in the pathogenesis of experimental autoimmune encephalomyelitis...
- Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro modelsDerek C Lacey
Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
J Immunol 188:5752-65. 2012GM-CSF and M-CSF (CSF-1) induce different phenotypic changes in macrophage lineage populations...
- Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axisC Henrique Serezani
Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
J Immunol 189:906-15. 2012..1, and PU.1 small interfering RNA abolished LTB(4)-enhanced dectin-1 expression. GM-CSF controls PU.1 expression, and this cytokine was decreased in LT-deficient macrophages...
- GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cellsMelanie Greter
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunity 36:1031-46. 2012GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and resident CD103(+) DCs in some tissues...
- Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33Monique A M Willart
Laboratory of Immunoregulation and Mucosal Immunology, Ghent University, 9000 Ghent, Belgium
J Exp Med 209:1505-17. 2012..release of IL-1α, which then acted in an autocrine manner to trigger the release of DC-attracting chemokines, GM-CSF, and IL-33...
- Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27Andrew Young
Centre for Infection and Immunity, Queen s University Belfast, Belfast BT9 7AE, Northern Ireland
J Immunol 189:2079-83. 2012GM-CSF is a potent proinflammatory cytokine that plays a pathogenic role in the CNS inflammatory disease experimental autoimmune encephalomyelitis...
- Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfismM W Sornson
Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093, USA
Nature 384:327-33. 1996..These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis...
- High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promotersS R Himes
Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
Immunity 5:479-89. 1996..We show that the CK-1 element (CD28RE) within the GM-CSF promoter binds the RelA and c-Rel transcription factors in response to CD28 activation...
- Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiationM Kieslinger
Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
Genes Dev 14:232-44. 2000..Bone marrow cells from these animals displayed a strong increase in apoptotic cell death during GM-CSF-dependent functional maturation in vitro...
- Nf1 and Gmcsf interact in myeloid leukemogenesisR A Birnbaum
Department of Pediatrics, University of California, San Francisco 94143 0519, USA
Mol Cell 5:189-95. 2000..We generated hematopoietic cells deficient in both Nf1 and Gmcsf to test whether GM-CSF is required to drive excessive proliferation of Nf1-/- cells in vivo...
- GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lungPierre Yves Berclaz
Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Blood 100:4193-200. 2002Severely impaired pulmonary microbial clearance was observed in granulocyte-macrophage colony-stimulating factor (GM-CSF)-deficient mice...
- Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1Pierre Yves Berclaz
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 169:6332-42. 2002GM-CSF gene-targeted (GM(-/-)) mice have impaired pulmonary clearance of bacterial and fungal pathogens by alveolar macrophages (AMs)...
- Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytesDavid K Jin
Department of Genetic Medicine, Division of Hematology Medical Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
Nat Med 12:557-67. 2006..revascularization of ischemic hindlimbs was partially diminished in mice deficient in both GM-CSF and G-CSF (Csf2-/- Csf3-/-), profound impairment in neovascularization was detected in sKitL-deficient Mmp9-/- as well as ..
- GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic (NOD) mouse myeloid cellsF Seydel
Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
J Autoimmun 31:377-84. 2008..We found that GM-CSF can regulate the binding of STAT5 on the promoter of its own gene, Csf2, within regions previously identified as sites of chromatin epigenetic modification important to the regulation of ..
- Increased tolerance to endotoxin by granulocyte-macrophage colony-stimulating factor-deficient miceS Basu
Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, Royal Melbourne Hospital, Victoria, Australia
J Immunol 159:1412-7. 1997The contribution of granulocyte-macrophage CSF (GM-CSF) to endotoxin-mediated septic shock has been assessed by treating GM-CSF-deficient mice with LPS...
- Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivityS Gillessen
Department of Adult Oncology, Dana Farber Cancer Institute Harvard Medical School, Boston, MA, USA
Blood 97:922-8. 2001Studies of mice rendered deficient in granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3) have established unique roles for these cytokines in pulmonary homeostasis, resistance to infection, and antigen-..
- Local transgenic expression of granulocyte macrophage-colony stimulating factor initiates autoimmunityM Biondo
Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia
J Immunol 166:2090-9. 2001..Here we tested whether local production of GM-CSF, a pro-inflammatory cytokine, is sufficient to break tolerance and initiate autoimmunity...
- Fine-structure mapping of the murine IL-3 and GM-CSF genes by pulsed-field gel electrophoresis and molecular cloningJ S Lee
Medical Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT
Genomics 5:359-62. 1989..In the present work we have derived a map of the region covering the Il-3 and Csfgm loci using a combination of pulsed-field gel electrophoresis and molecular cloning...
- Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traitsM A Yui
Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Mamm Genome 7:331-4. 1996..These results demonstrate the utility of this congenic approach for the study of complex genetic traits...
- Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injuryRobert Paine
Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA
Am J Pathol 163:2397-406. 2003Granulocyte macrophage-colony stimulating factor (GM-CSF) plays an important role in pulmonary homeostasis, with effects on both alveolar macrophages and alveolar epithelial cells...
- GM-CSF increases cross-presentation and CD103 expression by mouse CD8⁺ spleen dendritic cellsYifan Zhan
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Eur J Immunol 41:2585-95. 2011..Little is known about how these functions of CD8(+) DCs are modulated. Here, we show that granulocyte-macrophage CSF (GM-CSF), a cytokine that exists at low levels at steady state but is elevated during infection and inflammation, ..
- Local delivery of GM-CSF protects mice from lethal pneumococcal pneumoniaKathrin Steinwede
Department of Experimental Pneumology, Hannover Medical School, Hannover 30625, Germany
J Immunol 187:5346-56. 2011The growth factor GM-CSF has an important role in pulmonary surfactant metabolism and the regulation of antibacterial activities of lung sentinel cells...
- GM-CSF provides autocrine protection for murine alveolar epithelial cells from oxidant-induced mitochondrial injuryAnne Sturrock
Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Univ of Utah School of Medicine, Salt Lake City, UT 84132, USA
Am J Physiol Lung Cell Mol Physiol 302:L343-51. 2012..Overexpression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the lung protects against these effects, although the mechanisms are not yet clear...
- IL-2 and GM-CSF are regulated by DNA demethylation during activation of T cells, B cells and macrophagesYan Li
College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi 712100, PR China
Biochem Biophys Res Commun 419:748-53. 2012..We found that the expression of two cytokines (IL-2 and GM-CSF) responded differently to activation in three types of immune cells: EL4, A20 and RAW264.7 cells...
- CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3Cyril Seillet
Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Blood 121:1574-83. 2013..Collectively, these results uncover a previously undescribed pathway by which CD8α+ DCs emerge independent of Id2, Nfil3, and Batf3, but dependent on Irf8...
- Single proline substitutions in predicted alpha-helices of murine granulocyte-macrophage colony-stimulating factor result in a loss in bioactivity and altered glycosylationS W Altmann
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104
J Biol Chem 266:5333-41. 1991....
- A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and humanA M Buchberg
Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
Genetics 122:153-61. 1989..to mouse chromosome 11 by somatic cell hybrid or genetic backcross analysis were determined (Erbb, Rel, 11-3, Csfgm, Trp53-1, Evi-2, Erba, Erbb-2, Csfg, Myhs, Cola-1, Myla, Hox-2 and Pkca)...
- Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factorN M Gough
Nature 309:763-7. 1984DNA clones specifying the murine granulocyte-macrophage colony stimulating factor have been isolated...
- Transgenic mice in the study of cytokine functionJ Taverne
University College London Medical School, Department of Immunology, UK
Int J Exp Pathol 74:525-46. 1993
- IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic proteinE U Sarmiento
Department of Immunology Microbiology, Rush Medical College, Chicago, IL 60612, USA
J Immunol 155:2211-21. 1995We have examined the potential of IL-3, IL-5, and granulocyte-macrophage (GM)-CSF to enhance basophil activation by eosinophil granule major basic protein (MBP). Preincubating basophil-containing mononuclear cells with 0...
- Localization of sequences related to the human RAD6 DNA repair gene on mouse chromosomes 11 and 13M L Roller
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
Mamm Genome 6:305-6. 1995
- The transcription factor Sp1 is required for induction of the murine GM-CSF promoter in T cellsE S Masuda
Department of Cellular Biology, DNAX Research Institute, Palo Alto, CA 94304
Biochem Biophys Res Commun 205:1518-25. 1994The cis-acting region, GM-kappa B/GC-box (positions -95 and -73), within the murine GM-CSF gene promoter is required for maximal induction by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in T cells...
- Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasisH W Murray
Division of Infectious Diseases, Cornell University Medical College, New York 10021
J Clin Invest 95:1183-92. 1995GM-CSF induces three effects potentially beneficial in visceral leishmaniasis: blood monocyte mobilization, macrophage activation, and amelioration of granulocytopenia...
- Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during developmentY Chang
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032
J Neuroimmunol 52:9-17. 1994..Cytokines studied were interleukin (IL)-1 alpha, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, macrophage-colony stimulating factor (M-CSF), granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor ..
- Molecular basis for developmental changes of GM-CSF gene inducibility in embryonal carcinoma cellsT Heike
Department of Pediatrics, Faculty of Medicine, Kyoto University, Japan
Biochem Biophys Res Commun 198:473-9. 1994In a previous report, we reported that the induction of GM-CSF gene in differentiated P19 cells results from the maturation of the transcriptional machinery...
- Mapping the ovine genes encoding IL3, IL4, IL5, and CSF2 to sheep chromosome 5q13-q15 by FISHR J Hawken
Centre for Animal Biotechnology, University of Melbourne, Parkville, Australia
Mamm Genome 7:858-9. 1996
- Structural organization and expression of the gene for the mouse GM2 activator proteinC Bertoni
Dipartimento di Biologia Cellulare e Molecolare, Universita di Perugia, Italy
Mamm Genome 8:90-3. 1997..Northern blot analysis demonstrated variation in the GM2 activator protein mRNA expression during mouse development. Gm2a was mapped to Chromosome (Chr) 11, where it co-segregated with Csfgm.
- Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transductionH Jiao
Department of Cancer Biology, Cleveland Clinic Research Institute, OH 44195, USA
Exp Hematol 25:592-600. 1997..mice die from pulmonary accumulation of macrophages that are regulated by macrophage colony-stimulating factor (M-CSF) and granulocyte (G)-M-CSF...
- Granulocyte-macrophage colony-stimulating factor-deficient mice have impaired resistance to blood-stage malariaJ Riopel
Centre for the Study of Host Resistance, McGill University and The Montreal General Hospital Research Institute, Montreal, Quebec, Canada
Infect Immun 69:129-36. 2001The contribution of granulocyte-macrophage colony-stimulating factor (GM-CSF), a hematopoietic and immunoregulatory cytokine, to resistance to blood-stage malaria was investigated by infecting GM-CSF-deficient (knockout [KO]) mice with ..
- Granulocyte macrophage-colony stimulating factor (GM-CSF) recruits immune cells to the pancreas and delays STZ-induced diabetesMichelle Krakowski
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Pathol 196:103-12. 2002Granulocyte macrophage-colony stimulating factor (GM-CSF) is one of the most widely used growth factors for enhancing immune responses and is known to recruit and activate antigen-presenting cells (APCs)...
- Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) miceAzusa Ujike
Department of Experimental Immunology and CREST Program of JST, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4 1, Sendai 980 8575, Japan
Nat Immunol 3:542-8. 2002..Thus, PIR-B is critical for B cell suppression, DC maturation and for balancing T(H)1 and T(H)2 immune responses...
- Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory functionGeorge Miller
Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Immunol 169:2875-85. 2002GM-CSF is critical for dendritic cell (DC) survival and differentiation in vitro. To study its effect on DC development and function in vivo, we used a gene transfer vector to transiently overexpress GM-CSF in mice...
- Molecular cloning and expression of gerbil granulocyte/macrophage colony-stimulating factorDenis Gaucher
Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Ste Anne de Bellevue, QC, Canada H9X 3V9
Gene 294:233-8. 2002..of cDNA ends techniques, we cloned the cDNA encoding gerbil granulocyte/macrophage colony-stimulating factor (GM-CSF)...
- CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESISBethany Moore; Fiscal Year: 2002..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
- Collectin Deficiency in the mouseSamuel Hawgood; Fiscal Year: 2004..Although our studies are focused on a specific organism, we expect the mechanisms underlying collectin-IAV-host interactions will pertain more generally to the action of collectins in respiratory immune responses. ..
- GM-CSF THERAPY FOR ALVEOLAR PROTEINOSISMary Jane Thomassen; Fiscal Year: 2003..Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) deficient mice develop a PAP like syndrome which is corrected by exogenous GM-CSF, suggesting a ..
- Cytokine Dysregulation in GM-CSF AutoimmunityMary Jane Thomassen; Fiscal Year: 2007..recognized autoimmune disorder characterized by neutralizing autoantibodies to granulocyte-macrophage colony stimulating factor (GMCSF) and severely dysregulated lung surfactant metabolism, the GM-CSh requirement in normal ..
- STAT5 and PGS2 Dysfunction in Type 1 DiabetesSally Litherland; Fiscal Year: 2005..autoimmune PGS2/COX2 expression was highly resistant to IL-10 suppression, and that high autocrine production of GM-CSF by at-risk/Type1 diabetic human monocytes and non-obese diabetic (NOD) mouse macrophages promotes a build up of ..
- Cytokine Signaling in Autoimmune APC DysfunctionSally Litherland; Fiscal Year: 2005Both overexpression and knock-out deletion of granulocyte-macrophage colony stimulating factor (GM-CSF) in mice can lead to dysregulation of myeloid differentiation and autoimmune disease...
- PGE2 Regulation of Epithelial/Fibroblast InteractionsBethany Moore; Fiscal Year: 2006..abstract_text> ..
- FASEB Summer Research Conference, Lung Surfactant: Molecular and Cell BiologySamuel Hawgood; Fiscal Year: 2006..unreadable] 5. Collectins and mucosal host defense. [unreadable] 6. Design of novel surfactant-based therapeutics. [unreadable] [unreadable] [unreadable] [unreadable]..
- PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMGEORGE DEEPE; Fiscal Year: 2007..months and sustaining its durability requires tumor necrosis factor (TNF)-c_ and granulocyte-macrophage colony stimulating factor (GM-CSF) but not interleukins-10 or -12 or interferon-[unreadable]...
- Zeiss LSM 510 Laser Scanning MicroscopeMercedes Gonzalez Juarrero; Fiscal Year: 2007..The initial service contracts will derive from the guarantee of the machine and thereafter, users' feel will be responsible for the cost of the facility. [unreadable] [unreadable] [unreadable]..
- Defending Against Systemic MycosesGEORGE DEEPE; Fiscal Year: 2008..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..