Genomes and Genes
Gene Symbol: Csf1r
Description: colony stimulating factor 1 receptor
Alias: AI323359, CD115, CSF-1R, Csfmr, Fim-2, Fim2, Fms, M-CSF-R, M-CSFR, macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, c-fms, proto-oncogene c-Fms, proto-oncogene fms
Publications137 found, 100 shown here
- Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental developmentR J Arceci
Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, NY 10461
Proc Natl Acad Sci U S A 86:8818-22. 1989....
- Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineageV W Keng
Graduate School of Bioagricultural Sciences, Chikusa ku, Nagoya, 464 8601, Japan
Biochem Biophys Res Commun 276:1155-61. 2000..These results indicate that Hex plays an essential role in progenitor cells which commit to the hepatic endoderm and in the hematopoietic differentiation of the monocyte lineage...
- Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapySaul J Priceman
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
Blood 115:1461-71. 2010..CSF-1 receptor (CSF1R) signaling is important for the recruitment of CD11b(+)F4/80(+) tumor-associated macrophages (TAMs) and ..
- A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms geneHanna Krysinska
University of Leeds, Leeds Institute of Molecular Medicine, St James s University Hospital, Wellcome Trust Brenner Building, Leeds LS9 7TF, United Kingdom
Mol Cell Biol 27:878-87. 2007..low-level transcription and partial chromatin reorganization of myeloid cell-specific genes including the c-fms (csf1R) locus. Expression of the c-fms gene is dependent on the Ets family transcription factor PU...
- Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPSJ M Osborne
Department of Microbiology, Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
J Leukoc Biol 64:692-701. 1998..Attempts to express mDEP-1 constitutively in the macrophage cell line RAW264 were unsuccessful, with results suggesting that the gene product inhibits cell proliferation...
- CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphologyWenfeng Yu
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
J Leukoc Biol 84:852-63. 2008..The MacCsf1r-/- macrophage line will facilitate genetic and proteomic approaches to CSF-1R structure/function studies in the major disease-related CSF-1R-expressing cell type...
- The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulationBenjamin Pakuts
Department of Medical Biophysics, University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
J Biol Chem 282:17953-63. 2007..Using murine myeloid cells expressing CSF-1R (FD-Fms cells), we show that SLAP-2 is tyrosine-phosphorylated upon stimulation with CSF-1 and associates constitutively ..
- Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1Adrian Zarebski
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Immunity 28:370-80. 2008..This shared transcriptional pathway may provide new avenues for understanding SCN caused by mutations in other genes and for clinical intervention into human neutropenias...
- Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminusF H Qiu
Laboratory of Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
EMBO J 7:1003-11. 1988..These structural alterations are likely determinants of the oncogenic activation of v-kit.(ABSTRACT TRUNCATED AT 250 WORDS)..
- PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiationM C Olson
Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
Immunity 3:703-14. 1995..1-/- ES cells. Development of macrophages is restored with the introduction of a PU.1 cDNA regulated by its own promoter. The PU.1-/- ES cells represent an important model for analyzing myeloid cell development...
- VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient miceShumpei Niida
Department of Bone and Joint Disease, Research Institute, National Center for Geriatrics and Gerontology, Aichi 474 8522, Japan
Proc Natl Acad Sci U S A 102:14016-21. 2005..These results strongly suggest that the interaction of signals by means of VEGFR-1 and the CSF-1 receptor plays a predominant role not only in osteoclastogenesis but also in the maintenance of bone marrow functions...
- A CSF-1 receptor phosphotyrosine 559 signaling pathway regulates receptor ubiquitination and tyrosine phosphorylationYing Xiong
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 286:952-60. 2011..Thus the results indicate that CSF-1-mediated receptor dimerization leads to a Tyr-559/SFK/c-Cbl pathway resulting in receptor ubiquitination that permits full receptor tyrosine phosphorylation of this class III RTK in macrophages...
- Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactionsM Reedijk
Department of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
EMBO J 11:1365-72. 1992..Complex formation between the CSF-1R and PI 3'-kinase can therefore be reconstructed in vitro in a specific interaction involving the phosphorylated receptor KI and the SH2 domains of p85 alpha...
- Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptorM Reedijk
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
Mol Cell Biol 10:5601-8. 1990..of the receptor and cellular transformation require exogenous CSF-1, whereas NIH 3T3 cells expressing mouse c-fms are transformed by autocrine stimulation...
- fim-1 and fim-2: two new integration regions of Friend murine leukemia virus in myeloblastic leukemiasB Sola
J Virol 60:718-25. 1986..Rearrangements of these two regions were found in F-MuLV-induced myeloblastic leukemias but not in 20 lymphoid or erythroid leukemias induced by the same virus...
- Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblastsP van der Geer
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92186 5800
EMBO J 12:5161-72. 1993..Tyr697 was identified as a binding site for GRB2. We suggest that PI 3-kinase, GRB2 and some of the GRB2-associated proteins could play an important role in signal transduction by the CSF-1 receptor...
- Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alphaJ A Hamilton
Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
J Immunol 156:2553-7. 1996..it is proposed that the type I IFN receptor (IFNAR 1) "knockout" mice may be useful in delineating some of the in vivo actions of CSF-1, LPS, TNF-alpha, and possibly other agents...
- Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopeniaA Hart
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Immunity 13:167-77. 2000..We map the megakaryocytic defects in 14 Jacobsen patients to a minimal region on 11q that includes the Fli-1 gene and suggest that dysmegakaryopoiesis in these patients may be caused by hemizygous loss of Fli-1...
- A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulationCynthia M Rohde
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109, USA
J Biol Chem 279:43448-61. 2004..These findings may have implications for the oncogenic conversion of c-Kit and Flt3 with JMD mutations...
- PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2Yukiko Aikawa
Molecular Oncology Division, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan
Nat Med 16:580-5, 1p following 585. 2010..1 to stimulate the expression of macrophage colony-stimulating factor receptor (CSF1R, also known as M-CSFR, c-FMS or CD115). Studies using PU.1-deficient mice showed that PU...
- The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1C J Sherr
Cell 41:665-76. 1985The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen...
- Murine c-fms cDNA: cloning, sequence analysis and retroviral expressionV M Rothwell
Cell Biology Department, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Oncogene Res 1:311-24. 1987We have isolated and sequenced a cDNA clone coding for the murine c-fms gene. The 3677 nucleotide cDNA clone codes for a protein of 976 amino acids, which has 76% and 75% homology to the v-fms and human proteins, respectively...
- Role of colony-stimulating factor-1 in bone metabolismR Felix
Department of Pathophysiology, University of Bern, Switzerland
J Cell Biochem 55:340-9. 1994..The expression of CSF-1 receptors, encoded by the proto-oncogene c-fms, by osteoclast precursors and osteoclasts, suggested an effect of this cytokine not only during osteoclast ..
- Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during developmentY Chang
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032
J Neuroimmunol 52:9-17. 1994..Transcripts encoding the M-CSF receptor (c-fms) were also detected at all of these time points...
- Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongationX Yue
Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia
Mol Cell Biol 13:3191-201. 1993The gene encoding the receptor for macrophage colony-stimulating factor 1 (CSF-1), the c-fms protooncogene, is selectively expressed in immature and mature mononuclear phagocytes and trophoblasts. Exon 1 is expressed only in trophoblasts...
- Biology and action of colony--stimulating factor-1E R Stanley
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
Mol Reprod Dev 46:4-10. 1997..The CSF-1R is a tyrosine kinase encoded by the c-fms proto-oncogene product...
- The role of CSF-1 in normal and neoplastic breast physiologyE Sapi
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
Proc Soc Exp Biol Med 220:1-8. 1999Colony stimulating factor (CSF-1) and its receptor (CSF-1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation...
- Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1A M Lichanska
Department of Microbiology and Centre for Molecular and Cellular Biology, University of Queensland, Queensland, Australia
Blood 94:127-38. 1999..The mouse c-fms mRNA, encoding the receptor for macrophage colony-stimulating factor (CSF-1), was expressed on phagocytic cells in ..
- Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouseJ Palis
University of Rochester Medical Center, Department of Pediatrics and Cancer Center, Box 777, Rochester, NY 14642, USA rochester edu
Development 126:5073-84. 1999....
- A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expressionS R Himes
Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
J Leukoc Biol 70:812-20. 2001The c-fms gene encodes the receptor for macrophage colony-stimulating factor-1. This gene is expressed selectively in the macrophage cell lineage...
- Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defectsXu Ming Dai
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Blood 99:111-20. 2002..To investigate the in vivo specificity of CSF-1 for the CSF-1R, the mouse Csf1r gene was inactivated...
- Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cellsHiromi Tagoh
Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
Genes Dev 16:1721-37. 2002Expression of the gene for the macrophage colony stimulating factor receptor (CSF-1R), c-fms, has been viewed as a hallmark of the commitment of multipotent precursor cells to macrophages...
- Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progressionHisamitsu Ide
Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 99:14404-9. 2002..These observations correlate CSF-1R expression with changes in the growth and development of the normal and neoplastic prostate...
- Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejectionMatthew D Jose
Department of Nephrology, Monash Medical Centre, Melbourne, Australia
Am J Transplant 3:294-300. 2003..importance of M-CSF in driving macrophage proliferation during acute rejection, we blocked the M-CSF receptor, c-fms, in a mouse model of acute renal allograft rejection...
- Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient miceLinda Banaei-Bouchareb
INSERM U457, Paris, France
J Leukoc Biol 76:359-67. 2004..The demonstration of the colony-stimulating factor 1-dependent macrophage involvement in life-time pancreas development/remodeling allows us to pinpoint the tissue-modeling and remodeling functions of this leukocyte lineage...
- Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing boneXu Ming Dai
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Bone Miner Res 19:1441-51. 2004..We therefore examined the micro- and ultrastructure of the developing bones of osteoclast-deficient CSF-1R-nullizygous mice (Csf1r(-/-) mice).
- Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversibleHiromi Tagoh
Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
EMBO J 23:4275-85. 2004The murine c-fms (Csf1r) gene encodes the macrophage colony-stimulating factor receptor, which is essential for macrophage development...
- Langerhans cells arise from monocytes in vivoFlorent Ginhoux
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Nat Immunol 7:265-73. 2006..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...
- Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in miceJia Li
Department of Development and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Genesis 44:328-35. 2006..To distinguish cell type specific phenotypes, we have created a conditional allele of the Csf1r by placing LoxP sites around Exon 5 of the Csf1r gene in mice...
- A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populationsKatharine M Irvine
Cooperative Research Centre for Chronic Inflammatory Diseases and Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
FASEB J 20:1921-3. 2006..CSF-1R inhibitors such as CYC10268 provide a powerful tool to dissect the role of the CSF-1/CSF-1R signaling system in a range of biological systems and have potential for a number of therapeutic applications...
- A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis modelHiroaki Ohno
Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, 3 Miyahara, Takasaki, Gunma, 370 1295, Japan
Mol Cancer Ther 5:2634-43. 2006..In this study, we investigated whether an inhibitor of M-CSF receptor (c-Fms) suppresses osteoclast-dependent osteolysis in bone metastatic lesions...
- Origin of the lamina propria dendritic cell networkMilena Bogunovic
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
Immunity 31:513-25. 2009..lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands...
- The origin and development of nonlymphoid tissue CD103+ DCsFlorent Ginhoux
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Exp Med 206:3115-30. 2009..DCs are related to lymphoid organ CD8(+) DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8)...
- IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activationT Chihara
Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan
Cell Death Differ 17:1917-27. 2010Macrophage colony-stimulating factor (M-CSF) regulates the production, survival and function of macrophages through Fms, the receptor tyrosine kinase...
- Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cellsSuwen Wei
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Leukoc Biol 88:495-505. 2010..Thus, the different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues...
- An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammationKelli P A MacDonald
Queensland Institute of Medical Research, Brisbane, Australia
Blood 116:3955-63. 2010..phagocyte system requires macrophage colony-stimulating factor (CSF-1) signaling through the CSF-1 receptor (CSF1R, CD115)...
- Fate mapping analysis reveals that adult microglia derive from primitive macrophagesFlorent Ginhoux
Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
Science 330:841-5. 2010..These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders...
- Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficitsBryna Erblich
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York, United States of America
PLoS ONE 6:e26317. 2011..b>Csf1r nulls rarely survive to adulthood and therefore to study the role of CSF-1R in olfaction we used the viable null ..
- Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signalingSalvatore J Coniglio
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Mol Med 18:519-27. 2012....
- The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturationSayan Nandi
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
Dev Biol 367:100-13. 2012..Here we show that compared to wild type mice, CSF-1R-deficient (Csf1r-/-) mice have smaller brains of greater mass...
- The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1Heli Liu
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Biochim Biophys Acta 1824:938-45. 2012..negative cooperativity of CSF-1 at the receptor-recognition sites, in combination with the difference in hydrophobicity which dictates a more stable IL-34:CSF-1R complex compared to the CSF-1:CSF-1R complex...
- c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functionsYongzheng He
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
PLoS ONE 7:e46900. 2012..Here, we show that M-CSF binding to its receptor, c-Fms, results in increased c-Fms activation in Nf1(+/) (-) osteoclast progenitors, mediating multiple gain-in-functions ..
- Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survivalJian Luo
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 210:157-72. 2013Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the CSF1 receptor (CSF1R) and thus are key regulators of the monocyte/macrophage lineage...
- The CSF-1 receptor fashions the intestinal stem cell nicheDilara Akcora
Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department, University of Melbourne, Australia
Stem Cell Res 10:203-12. 2013..Nevertheless, we previously showed that germline CSF-1 receptor (Csf1r) knock out (KO) or Csf1 mutation is associated with an absence of mature PC, reduced crypt proliferation and ..
- CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress responseDuy Huynh
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
PLoS ONE 8:e56951. 2013..Colons from Csf1r null and Csf1(op/op) mice were isolated and sectioned for IHC identification of enterocytes, enteroendocrine cells,..
- AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 geneH Okada
Department of Cell Biology, Cancer Institute, Tokyo, Japan
Oncogene 17:2287-93. 1998..The results suggest that the expression of a particular set of hematopoiesis-related genes is closely correlated with the PEBP2/CBF function...
- Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cellsS Murase
Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Neurosci 18:10481-92. 1998To investigate whether the c-fms proto-oncogene plays a role in the CNS, we examined its expression in mouse brain...
- SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophagesK L Berg
Department of Developmental Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 274:35855-65. 1999..Thus, p62(DOK) is a major SHP-1 substrate whose tyrosine phosphorylation correlates with growth factor-independent survival in macrophages...
- T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiationPaul D Simoncic
Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Mol Cell Biol 26:4149-60. 2006..These data implicate Tcptp as a critical regulator of CSF-1 signaling and mononuclear phagocyte development in hematopoiesis...
- Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1R Tedjo Sasmono
CRC for Chronic Inflammatory Diseases and ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
J Leukoc Biol 82:111-23. 2007..is controlled by macrophage colony-stimulating factor (CSF-1), which binds to a receptor (CSF-1R) encoded by the c-fms proto-oncogene...
- Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse developmentR J Arceci
Pediatric Hematology Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
Dev Biol 151:1-8. 1992c-fms and c-kit are structurally related tyrosine kinase receptors for colony-stimulating factor-1 (CSF-1) and for steel factor (SF), respectively...
- The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both speciesK Kaupmann
Developmental Biology Unit, University of Bielefeld, Germany
Genomics 14:488-90. 1992..The gene order cen-Junb-Um-Tat-(Cdh3/Aprt) was determined. The human homologue CDH3 was mapped to chromosome 16q24.1-qter by analyzing human/mouse somatic cell hybrids...
- A molecular genetic linkage map of mouse chromosome 18, including spm, Grl-1, Fim-2/c-fms, and MbpY Sakai
Department of Biochemistry, Aichi Prefecture Colony, Japan
Biochem Genet 29:103-13. 1991..m. molossinus, Chinese mice of wild origin, and M. m. yamashinai) carry the Grl-1b, Fim-2b, and Mbpb alleles. Only castaneus strains carry the intermediate combination of the Grl-1b, Fim-2a, and Mbpb alleles...
- Biochemical and genetic characterization of multiple splice variants of the Flt3 ligandT McClanahan
DNAX Research Institute of Molecular and Cellular Biology, Department of Molecular Biology, Palo Alto, CA 94304, USA
Blood 88:3371-82. 1996..FL), c-Kit ligand (KL), and macrophage colony-stimulating factor as well as their receptors, Flt3, c-Kit, and c-Fms. The message for FL is unusually ubiquitous, whereas that of its receptor is quite restricted, apparently limiting ..
- Equine synteny mapping of comparative anchor tagged sequences (CATS) from human Chromosome 5A R Caetano
University of California Davis, Veterinary Genetics Laboratory, Davis, California 95616 8744, USA
Mamm Genome 10:1082-4. 1999....
- Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domainsM Masuhara
Institute of Life Science, Kurume University, Aikawamachi 2432 3, Kurume, 839 0861, Japan
Biochem Biophys Res Commun 268:697-703. 2000..A two-hybrid assay indicated that STAP-1 bound not only to c-kit but also to c-fms but not to JAK2 or Pyk2. In 293 cells, STAP-1 was tyrosine-phosphorylated by activated c-kit...
- The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturationSijin Liu
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Clin Invest 117:3296-305. 2007..This work demonstrates that HRI deficiency attenuates hepcidin expression and iron homeostasis in mice, indicating a potential role for HRI in the anemia of inflammation...
- Expression of macrophage colony-stimulating factor (M-CSF) and its receptor in streptozotocin-induced diabetic ratsWei Liu
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
Curr Eye Res 34:123-33. 2009..To demonstrate the expression and location of macrophage colony-stimulating factor (M-CSF) and its receptor (CSF-1R) in the retinas of diabetic rats, as well as in vitreous human proliferative diabetic retinopathy (PDR)...
- A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic miceDmitry A Ovchinnikov
Institute for Molecular Bioscience, University of Queensland, Australia
J Leukoc Biol 87:815-22. 2010b>Csf1r mRNA in adult mice is expressed in cells of the macrophage lineage, and during development, it is also expressed from a separate promoter in placental trophoblast cells...
- Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5Richard M Ingram
Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
Exp Hematol 39:730-40.e1-2. 2011..determined the molecular mechanism by which PAX5 silences the myeloid-specific colony-stimulating-factor-receptor (Csf1R) gene and showed that PAX5 directly binds to the Csf1r promoter as well as to an intronic enhancer that generates ..
- Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammationJason C Lenzo
Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Immunol Cell Biol 90:429-40. 2012..A correlation has been observed between macrophage numbers and the severity of certain inflammatory conditions, and it could be that CSF-1 and GM-CSF contribute to the control of these numbers in the ways proposed...
- Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinaseOlivier Zwaenepoel
Department of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece
FASEB J 26:691-706. 2012..These findings may have important implications in cancer development...
- Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principlesJonathan Elegheert
Unit for Structural Biology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University, K L Ledeganckstraat 35, 9000 Ghent, Belgium
Structure 19:1762-72. 2011The hematopoietic colony stimulating factor-1 receptor (CSF-1R or FMS) is essential for the cellular repertoire of the mammalian immune system...
- Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophagesGuillaume Hoeffel
Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
J Exp Med 209:1167-81. 2012..Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development...
- M-CSF instructs myeloid lineage fate in single haematopoietic stem cellsNoushine Mossadegh-Keller
Centre d immunologie de Marseille Luminy, Aix Marseille Universite, UM2, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
Nature 497:239-43. 2013..This fundamentally changes the current view of how HSCs respond to environmental challenge and implicates stress-induced cytokines as direct instructors of HSC fate...
- Abl family kinases regulate endothelial barrier function in vitro and in miceElizabeth M Chislock
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America
PLoS ONE 8:e85231. 2013..kinases including the platelet-derived growth factor receptor (PDGFR), Kit, colony stimulating factor 1 receptor (CSF1R), and discoidin domain receptors, has shown protective effects in animal models of inflammation, sepsis, and other ..
- Pleiotropic effects of extended blockade of CSF1R signaling in adult miceKristin A Sauter
The Roslin Institute and Royal Dick School of Veterinary Studies and
J Leukoc Biol 96:265-74. 2014We investigated the role of CSF1R signaling in adult mice using prolonged treatment with anti-CSF1R antibody. Mutation of the CSF1 gene in the op/op mouse produces numerous developmental abnormalities...
- Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)Violeta Chitu
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neurobiol Dis 74:219-28. 2015Mutations in the colony stimulating factor-1 receptor (CSF1R) that abrogate the expression of the affected allele or lead to the expression of mutant receptor chains devoid of kinase activity have been identified in both familial and ..
- Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host diseaseMotoko Koyama
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
J Exp Med 212:1303-21. 2015....
- Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial InfarctionAnne Laure Leblond
Centre for Research in Vascular Biology CRVB, Biosciences Institute, University College Cork, College Road, Cork, Ireland
PLoS ONE 10:e0137515. 2015....
- Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophagesV Kanagasundaram
Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Mol Cell Biol 19:4079-92. 1999..Specific structural proteins associated with the separate CSF-1R multimeric complexes upon CSF-1 stimulation and the presence of the distinct pools of the CSF-1R were dependent on the integrity of the microtubular network...
- A multipoint genetic linkage map of mouse chromosome 18K R Johnson
Jackson Laboratory, Bar Harbor, Maine 04609
Genomics 13:1143-9. 1992..3-Tpi-10-11.8-(Egr-1, Hmg17-rs9)-2.1-Fgfa-2.2-Grl-1-10.1-(Cdx-1, Csfmr, Pdgfrb, Pdea, Rps14)-2.1-Adrb-2-22.9-Mbp...
- Colony stimulating factor 1 (CSF-1) and its in vivo role as delineated using osteopetrotic op/op miceW Wiktor-Jedrzejczak
Department of Immunology, Central Clinical Hospital, Military School of Medicine, Warsaw, Poland
Postepy Biochem 37:54-7. 1991
- Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell lineP van der Geer
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138 9216
Mol Cell Biol 10:2991-3002. 1990..In addition, we show that CSF-1 receptors are capable of autophosphorylation at six to eight major sites in vitro...
- A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and humanA M Buchberg
Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
Genetics 122:153-61. 1989..the known linkage homologies that exist between murine chromosome 11 and human chromosomes (Mpo, Ngfr, Pdgfr and Fms). Two of the latter genes, Mpo and Ngfr, mapped to mouse chromosome 11...
- Genetic mapping of the mouse c-fms proto-oncogene to chromosome 18M D Hoggan
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
J Virol 62:1055-6. 1988..X mouse somatic cell hybrids were analyzed by Southern blot hybridization with a probe specific for the cellular c-fms proto-oncogene...
- Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptorsL M Wang
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284
Genomics 3:172-6. 1988..The genes for CSF1R, CSF1, CSF2, IL-3, and IL-5 form a cluster on the long arm of human Chromosome 5...
- Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcriptionM A Collart
J Immunol 139:949-55. 1987..Taken together, these results suggest a possible role for the c-fos gene product, a nuclear protein, in the modulation of the functional activity of differentiated macrophages...
- Differential expression of cellular oncogenes during pre- and postnatal development of the mouseR Muller
Nature 299:640-4. 1982
- The genes coding for alpha and beta catenin (Catna1 and Catnb) and plakoglobin (Jup) map to mouse chromosomes 18, 9, and 11, respectivelyJ L Guenet
Unité de Génétique des Mammifères de l Institut Pasteur, Paris, France
Mamm Genome 6:363-6. 1995
- Detection of c-fms protooncogene in early mouse embryos by whole mount in situ hybridization indicates roles for macrophages in tissue remodellingD A Hume
Centre for Molecular and Cellular Biology, University of Queensland, Australia
Br J Haematol 90:939-42. 1995The c-fms protoncogene which encodes the receptor for macrophage colony-stimulating factor (CSF-1) was localized in the developing mouse embryo by whole in situ hybridization. c-fms was expressed first in placental trophoblasts. Around 9...
- Isolation of new oncogenic forms of the murine c-fms geneN de Parseval
Hopital Cochin, Institut Cochin de Genetique Moleculaire, U 363 Institut National de la Santé et de la Recherche Médicale, Universite Paris V, France
J Virol 69:3597-604. 1995The c-fms gene encodes the receptor for the macrophage colony-stimulating factor, which plays a key role in the proliferation and differentiation of cells of the myelomonocytic lineage...
- Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalizationG M Myles
Cell Biology Department, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Mol Cell Biol 14:4843-54. 1994The receptor (Fms) for macrophage colony-stimulating factor (M-CSF) is a member of the tyrosine kinase class of growth factor receptors...
- Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomesJ Santos
Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
Cytogenet Cell Genet 62:217-9. 1993DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
- Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase CD V Serreze
Jackson Laboratory, Bar Harbor, ME 04609
Proc Natl Acad Sci U S A 90:9625-9. 1993..These defects, in turn, were associated with an inability of CSF-1 to up-regulate c-fms (CSF-1 receptor) and Ifgr (gamma-interferon receptor) expression...
- Chromosomal assignment of seven genes on canine chromosomes by fluorescence in situ hybridizationM L Guevara-Fujita
Department of Human Genetics, University of Michigan Medical School, 4708 Medical Science Building II, Ann Arbor, Michigan 48109 0618, USA
Mamm Genome 7:268-70. 1996..These assignments are based on the karyotype proposed by Stone and associates (Genome 34, 407, 1991) using high-resolution techniques. In addition, we have assigned the Menkes gene to the X Chr of the dog...
- Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cellsE Ashihara
Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
J Cell Physiol 171:343-56. 1997..colony-stimulating factor (GM-CSF) receptor, the erythropoietin receptor, the G-CSF receptor, and c-Fms, the receptor for macrophage colony-stimulating factor (M-CSF)...
- IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patchesH Yoshida
Department of Molecular Genetics, Faculty of Medicine, Institute of Genetics, Faculty of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyoku, Kyoto 606 850, Japan
Int Immunol 11:643-55. 1999..Intestinal IL-7Ralpha+ cells are lymphoid in morphology but CD3(-) and functional in both nu/nu and Rag2-/- mice. These results implicate IL-7Ralpha+ CD3(-) cells as the direct inducer of the organizing center of PP...
- A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryoR J Passey
School of Pathology, University of New South Wales, Sydney, Australia
J Immunol 163:2209-16. 1999..The S100A8 null provides a new model for studying fetal-maternal interactions during implantation...
- Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophagesAxel Kallies
Department of Molecular Genetics, Institute of Molecular Pharmacology, Medical Center Benjamin Franklin, Free University of Berlin, Germany
Blood 99:3213-9. 2002..Congruently, the expression of a major endosomal/lysosomal protease, cathepsin B, is strongly reduced in ICSBP(-/-) BMMs...
- Macrophage accumulation at a site of renal inflammation is dependent on the M-CSF/c-fms pathwayYannick Le Meur
Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia
J Leukoc Biol 72:530-7. 2002..Therefore, we determined whether M-CSF, acting through its receptor c-fms, contributes to macrophage accumulation at a site of tissue injury...
- Protein Tyrosine Phosphatase and Macrophage FunctionFiona Pixley; Fiscal Year: 2005..2. To elucidate the role of PTP? in the regulation of paxillin tyrosine phosphorylation. 3. To determine the role of PTP? in mouse development and macrophage function. ..
- Predicting Melanoma Response to BAY 43-9006/ChemotherapyHarriet Kluger; Fiscal Year: 2008..We will assess individual markers as well as panels of markers. [unreadable] [unreadable]..
- Tyrosine Kinase Pathways in Autoimmune Arthritis.Ricardo Paniagua; Fiscal Year: 2008....
- ID2 IN CELL CYCLE REGULATION AND CANCERAntonio Iavarone; Fiscal Year: 2010..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..