Csf1

Summary

Gene Symbol: Csf1
Description: colony stimulating factor 1 (macrophage)
Alias: C87615, Csfm, MCSF, macrophage colony-stimulating factor 1, osteopetrosis
Species: mouse

Top Publications

  1. ncbi Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse development
    R J Arceci
    Pediatric Hematology Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Dev Biol 151:1-8. 1992
  2. pmc Delayed hematopoietic development in osteopetrotic (op/op) mice
    S K Begg
    Cell Biology Group, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    J Exp Med 177:237-42. 1993
  3. ncbi Effect of macrophage colony-stimulating factor (M-CSF) on mouse immune responses in vivo
    T Sakurai
    Biochemical Research Laboratory, Morinaga Milk Industry Co, Ltd, Kanagawa pref Japan
    Immunopharmacol Immunotoxicol 20:79-102. 1998
  4. ncbi Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice
    J Wegiel
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Brain Res 804:135-9. 1998
  5. pmc A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    Binzhi Qian
    Department of Developmental and Molecular Biology and the Department of Obstetrics Gynecology and Woman s Health, Center for the Study of Reproductive Biology and Woman s Health, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6562. 2009
  6. ncbi Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
    Xu Ming Dai
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 99:111-20. 2002
  7. doi IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation
    T Chihara
    Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    Cell Death Differ 17:1917-27. 2010
  8. ncbi Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    Jeffrey B Wyckoff
    Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:2649-56. 2007
  9. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
  10. ncbi Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis
    G R Ryan
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Blood 98:74-84. 2001

Research Grants

  1. EINSTEIN TRANSGENIC AND GENE TARGETING COURSE
    Jeffrey Pollard; Fiscal Year: 2004
  2. CSF-1, MACROPHAGES AND MALE REPRODUCTIVE FUNCTION
    Jeffrey Pollard; Fiscal Year: 2001
  3. Discovery and functional assessment of the rat op gene
    DAVID DOBBINS; Fiscal Year: 2004
  4. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
  5. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2006
  6. 2006 Reproductive Tract Biology Gordon Research Conference
    Jeffrey Pollard; Fiscal Year: 2006
  7. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2007
  8. Progesterone Action in the Uterus of Mice and Humans
    Jeffrey Pollard; Fiscal Year: 2008
  9. CSF-1 GENE EXPRESSION IN OSTEOCLAST BIOLOGY
    SHERRY ABBOUD WERNER; Fiscal Year: 2009
  10. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. ncbi Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse development
    R J Arceci
    Pediatric Hematology Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Dev Biol 151:1-8. 1992
    ..The patterns of CSF-1/c-fms mRNA and SF/c-kit mRNA expression are consistent with the hypothesis that these two ligand/receptor systems may act in a compensatory or synergistic manner during preimplantation development...
  2. pmc Delayed hematopoietic development in osteopetrotic (op/op) mice
    S K Begg
    Cell Biology Group, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    J Exp Med 177:237-42. 1993
    ..The data indicated that op/op mice undergo an age-related hematopoietic recovery and resolution of osteopetrosis, suggesting that the hematopoietic system has the capacity to use alternative mechanisms to compensate for the ..
  3. ncbi Effect of macrophage colony-stimulating factor (M-CSF) on mouse immune responses in vivo
    T Sakurai
    Biochemical Research Laboratory, Morinaga Milk Industry Co, Ltd, Kanagawa pref Japan
    Immunopharmacol Immunotoxicol 20:79-102. 1998
    ..These results suggest that administration of rhM-CSF not only activates murine macrophages, but modulates antigen-specific immune responses in vivo...
  4. ncbi Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice
    J Wegiel
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Brain Res 804:135-9. 1998
    ..Study suggests that CSF-1 plays a role in vivo in the formation and maturation of microglia and has little or no effect on perivascular cells...
  5. pmc A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    Binzhi Qian
    Department of Developmental and Molecular Biology and the Department of Obstetrics Gynecology and Woman s Health, Center for the Study of Reproductive Biology and Woman s Health, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6562. 2009
    ..However, at the metastatic site the role of these cells and their mechanism of actions for establishment and growth of metastases remain largely unknown...
  6. ncbi Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
    Xu Ming Dai
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 99:111-20. 2002
    ..The phenotype of Csf1(-)/Csf1r(-) mice closely resembled the phenotype of CSF-1-nullizygous (Csf1(op)/Csf1(op)) mice, including the ..
  7. doi IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation
    T Chihara
    Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    Cell Death Differ 17:1917-27. 2010
    ..Our findings indicate that macrophage phenotype and function are differentially regulated even at the level of the single receptor, Fms...
  8. ncbi Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    Jeffrey B Wyckoff
    Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:2649-56. 2007
    ..These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors...
  9. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
    ..Thus our results also indicate novel roles for the CSF-1R in the regulation of corticogenesis...
  10. ncbi Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis
    G R Ryan
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Blood 98:74-84. 2001
    ..To investigate tissue CSF-1 regulation, CSF-1-null Csf1(op)/Csf1(op) mice expressing transgenes encoding the full-length membrane-spanning CSF-1 precursor driven by 3...
  11. pmc Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation
    W W Wiktor-Jedrzejczak
    J Exp Med 156:1516-27. 1982
    ....
  12. ncbi Role of colony-stimulating factor-1 in reproduction and development
    J W Pollard
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Reprod Dev 46:54-60; discussion 60-1. 1997
    ..The pleiotropic roles for CSF-1 in reproduction and in the brain suggest that CSF-1 exerts many of its action through the trophic activities of cells of the mononuclear phagocytic lineage...
  13. pmc Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor
    M Naito
    Second Department of Pathology, Kumamoto University Medical School, Japan
    Am J Pathol 139:657-67. 1991
    ..This suggests that an M-CSF-independent population of macrophages is derived from granulocyte/macrophage-colony-forming cells (GM-CFC) or earlier hematopoietic progenitors...
  14. ncbi The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury
    O Berezovskaya
    Department of Anatomy, University of Saskatchewan, Saskatoon, Canada
    Int J Dev Neurosci 13:285-99. 1995
    ..We report some indications that CSF-1, in addition to modulation of microglia, may also act directly on neurons...
  15. pmc Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development
    R J Arceci
    Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 86:8818-22. 1989
    ....
  16. ncbi Role of colony-stimulating factor-1 in bone metabolism
    R Felix
    Department of Pathophysiology, University of Bern, Switzerland
    J Cell Biochem 55:340-9. 1994
    ..murine mutant strain op/op, results in low numbers of macrophages and monocytes and, most striking, leads to osteopetrosis due to a virtual absence of osteoclasts...
  17. ncbi Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation
    Deborah M Lenda
    Laboratory of Molecular Autoimmune Disease, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 170:3254-62. 2003
    ..To test this hypothesis, we evaluated renal inflammation during unilateral ureter obstruction in CSF-1-deficient (Csf1(op)/Csf1(op)) mice...
  18. pmc Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury
    Sarah L Pull
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:99-104. 2005
    ..Studies of B6 Csf1(op/op) (lacking macrophages) mice, Rag1(-/-) mice, and wild-type mice treated with neutrophil-specific Gr1 mAbs, ..
  19. ncbi Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse
    S C Marks
    J Hered 67:11-18. 1976
    b>Osteopetrosis (op/op) is a new mutation in the mouse that is transmitted as an autosomal recessive linked with variant waddler (Va) on chromosome 12...
  20. ncbi Differentiation of epidermal Langerhans cells in macrophage colony-stimulating-factor-deficient mice homozygous for the osteopetrosis (op) mutation
    K Takahashi
    Second Department of Pathology, Kumamoto University Medical School, Japan
    J Invest Dermatol 99:46S-47S. 1992
    The osteopetrosis (op) mutation is within the gene for macrophage colony-stimulating factor (M-CSF)...
  21. ncbi CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages
    W Wiktor-Jedrzejczak
    Department of Immunology, Military School of Medicine, Warsaw, Poland
    Exp Hematol 20:1004-10. 1992
    b>Osteopetrosis and the absence of colony-stimulating factor 1 (CSF-1) in op/op mice are associated with decreased cellularity of the bone marrow (to one tenth of the normal), a very significant reduction in the number of cells recovered ..
  22. ncbi A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility
    J W Pollard
    Department of Developmental Biology and Cancer, Albert Einstein College of Medicine AECOM, Bronx, New York 10461
    Dev Biol 148:273-83. 1991
    ..Further studies in the osteopetrotic mouse will be useful in delineating those functions required for pregnancy that are regulated by CSF-1...
  23. ncbi The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
    H Yoshida
    Department of Pathology, Kumamoto University Medical School, Japan
    Nature 345:442-4. 1990
    Mice homozygous for the recessive mutation osteopetrosis (op) on chromosome 3 have a restricted capacity for bone remodelling, and are severely deficient in mature macrophages and osteoclasts...
  24. pmc Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse
    W Wiktor-Jedrzejczak
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 87:4828-32. 1990
    Osteopetrotic (op/op) mutant mice suffer from congenital osteopetrosis due to a severe deficiency of osteoclasts. Furthermore, the total number of mononuclear phagocytes is extremely low in affected mice...
  25. ncbi The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1
    C J Sherr
    Cell 41:665-76. 1985
    ..The murine c-fms proto-oncogene product and the CSF-1 receptor are therefore related, and possibly identical, molecules...
  26. ncbi Microglia in colony-stimulating factor 1-deficient op/op mice
    G Blevins
    Canadian Network of Centres of Excellence, Department of Anatomy, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Neurosci Res 40:535-44. 1995
    Mice that are homozygous for the autosomal recessive mutation osteopetrosis (op) suffer from a general skeletal sclerosis, and the numbers of macrophages in various tissues are significantly decreased...
  27. ncbi Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse
    G Raivich
    Department of Neuromorphology, Max Planck Institute for Psychiatry, Martinsried, Germany
    Eur J Neurosci 6:1615-8. 1994
    ..osteopetrotic (op/op) mice, with a genetic deficiency in biologically active macrophage colony-stimulating factor (MCSF)...
  28. ncbi Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse
    M G Cecchini
    Department of Pathophysiology, University of Berne, Switzerland
    Development 120:1357-72. 1994
    ..Macrophages involved in inflammatory and immune (pathological) responses appear to be dependent on other factors for their ontogenesis and function.(ABSTRACT TRUNCATED AT 400 WORDS)..
  29. ncbi Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development
    Y Chang
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032
    J Neuroimmunol 52:9-17. 1994
    ....
  30. ncbi Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse
    M D Witmer-Pack
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    J Cell Sci 104:1021-9. 1993
    ..Prior work had shown that osteopetrosis is associated with a lack of osteoclasts, phagocytic cells required for remodelling in bone...
  31. ncbi CSF-1 deficiency in mice results in abnormal brain development
    M D Michaelson
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 122:2661-72. 1996
    ..The effects of CSF-1 on cultured embryonic neural cells, the developmentally appropriate expression of CSF-1 and its receptor, and the neurological abnormalities in op/op mice suggest a role for CSF-1 in brain development...
  32. ncbi Absence of colony-stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects
    P E Cohen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Reprod 55:310-7. 1996
    ....
  33. ncbi Biology and action of colony--stimulating factor-1
    E R Stanley
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Reprod Dev 46:4-10. 1997
    ..Studies on several of these proteins, including protein tyrosine phosphates 1C, the c-cbl proto-oncogene product, and protein tyrosine phosphatase-phi are discussed...
  34. ncbi Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation
    P E Cohen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Reprod 56:110-8. 1997
    ..Thus, the major effect of CSF-1 on female reproductive function is on the frequency and rate of ovulation, indicating a major role for this growth factor in regulating follicular development and ovulation...
  35. ncbi Effect of the colony-stimulating factor-1 null mutation, osteopetrotic (csfm(op)), on the distribution of macrophages in the male mouse reproductive tract
    J W Pollard
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Reprod 56:1290-300. 1997
    ..Mice homozygous for a null mutation (csfm(op)) in the gene for the mononuclear phagocytic growth factor colony-stimulating factor-1 (CSF-1) have a ..
  36. ncbi CSF-1 signal transduction
    J A Hamilton
    University of Melbourne Department of Medicine, Royal Melbourne Hospital, Parkville, Australia
    J Leukoc Biol 62:145-55. 1997
    ..The relevance of any potentially important molecular signaling pathway activated by CSF-1 in cells in vitro will ultimately have to be related to the functions of monocytes/macrophages in vivo...
  37. ncbi Colony-stimulating factor-1 plays a major role in the development of reproductive function in male mice
    P E Cohen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Endocrinol 11:1636-50. 1997
    ..Mice homozygous for the osteopetrosis mutation (csfm[op]) lack CSF-1 and, consequently, have depleted macrophage numbers...
  38. ncbi Normal development of dental innervation and nerve/tissue interactions in the colony-stimulating factor-1 deficient osteopetrotic mouse
    S I Nagahama
    Department of Anesthesiology, University of Washington, Seattle 98195 6540, USA
    Dev Dyn 211:52-9. 1998
    ..This study shows that op/op mice develop normal innervation in dental tissues and that dental nerve development proceeds independently of bone abnormalities and root failure in this animal...
  39. ncbi The role of CSF-1 in normal and neoplastic breast physiology
    E Sapi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Proc Soc Exp Biol Med 220:1-8. 1999
    ....
  40. ncbi Op/op mice defective in production of functional colony-stimulating factor-1 lack macrophages in muscularis externa of the small intestine
    H B Mikkelsen
    Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Cell Tissue Res 295:485-93. 1999
    ..in the colony-stimulating factor-1 (CSF-1) gene, which results in the absence of certain macrophages and in osteopetrosis, following a lack of osteoclasts...
  41. ncbi Postnatal mammary gland development requires macrophages and eosinophils
    V Gouon-Evans
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Development 127:2269-82. 2000
    ..Using mice homozygous for a null mutation in the gene for CSF1 (Csfm(op)/Csfm(op)), the major growth factor for macrophages, we show that in the absence of CSF1, the population of ..
  42. ncbi Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor
    A Sasaki
    First Department of Pathology, Gunma University School of Medicine, Maebashi, Japan
    Neuropathology 20:134-42. 2000
    ..The study also suggests that M-CSF affects the maturation of perivascular cells at the ultrastructural level...
  43. pmc Aberrant macrophage and neutrophil population dynamics and impaired Th1 response to Listeria monocytogenes in colony-stimulating factor 1-deficient mice
    I Guleria
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Infect Immun 69:1795-807. 2001
    ..Using mice homozygous for a null mutation (Csf1(op)) in the gene for the mononuclear phagocytic growth factor colony-stimulating factor 1 (CSF-1), we have ..
  44. pmc Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    E Y Lin
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Exp Med 193:727-40. 2001
    ..a transgenic mouse susceptible to mammary cancer with mice containing a recessive null mutation in the CSF-1 gene (Csf1(op)) and followed tumor progression in wild-type and null mutant mice...
  45. ncbi Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema
    Y Shibata
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 98:2845-52. 2001
    ..These data show that the AM deficiency observed in young Op/Op mice is spontaneously corrected with age and is associated with increased lung levels of IL-3, spontaneous MMP expression by AMs, and destruction of lung tissue...
  46. ncbi Colony-stimulating factor 1 regulation of neuroendocrine pathways that control gonadal function in mice
    Paula E Cohen
    Center for the Study of Reproductive Biology and Women s Health, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 143:1413-22. 2002
    ..Consequently mice lacking CSF-1 (Csf1(op)/Csf1(op)) have depleted populations of macrophages in many tissues...
  47. ncbi Macrophage accumulation at a site of renal inflammation is dependent on the M-CSF/c-fms pathway
    Yannick Le Meur
    Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia
    J Leukoc Biol 72:530-7. 2002
    ..Therefore, M-CSF/c-fms signaling plays a key role in macrophage accumulation during tissue injury...
  48. pmc The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification
    Liesbeth Van Wesenbeeck
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, Antwerp B 2610, Belgium
    Proc Natl Acad Sci U S A 99:14303-8. 2002
    ..The failure to resorb bone produces severe, unrelenting osteopetrosis, with a highly sclerotic skeleton, lack of marrow spaces, failure of tooth eruption, and other pathologies...
  49. ncbi Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejection
    Matthew D Jose
    Department of Nephrology, Monash Medical Centre, Melbourne, Australia
    Am J Transplant 3:294-300. 2003
    ..This pathway plays a significant and specific role in the accumulation of macrophages within a rejecting renal allograft...
  50. ncbi Amyloid beta protein deposition and neuron loss in osteopetrotic (op/op) mice
    Masato Kaku
    Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University, Graduate School of Biomedical Science, 1 2 3 Kasumi, Hiroshima 734 8553, Minami, Japan
    Brain Res Brain Res Protoc 12:104-8. 2003
    ..These results demonstrate that Abeta deposition influence neuron loss and it may be suspected that expression of SPs may be in part regulated by microglia under physiological conditions...
  51. ncbi Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice
    Linda Banaei-Bouchareb
    INSERM U457, Paris, France
    J Leukoc Biol 76:359-67. 2004
    ..5 days). F4/80-positive macrophages were found in pancreases recovered from Csf1op/Csf1+ (op/+) mice but were extremely scarce or absent in pancreas recovered from op/op ones at all studied time-points...
  52. pmc Langerhans cells arise from monocytes in vivo
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:265-73. 2006
    ..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...
  53. ncbi Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice
    Jia Li
    Department of Development and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genesis 44:328-35. 2006
    ..Null mutations in either the ligand or the receptor genes result in a severe osteopetrosis as well as a number of other phenotypes, including reproductive defects and perturbations in organ development...
  54. ncbi A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations
    Katharine M Irvine
    Cooperative Research Centre for Chronic Inflammatory Diseases and Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
    FASEB J 20:1921-3. 2006
    ..CSF-1R inhibitors such as CYC10268 provide a powerful tool to dissect the role of the CSF-1/CSF-1R signaling system in a range of biological systems and have potential for a number of therapeutic applications...
  55. ncbi Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    Elaine Y Lin
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 66:11238-46. 2006
    ..Taken together, this study shows that tumor-associated macrophages play a key role in promoting tumor angiogenesis, an essential step in the tumor progression to malignancy...
  56. ncbi Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation
    Andrew J Fleetwood
    Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 178:5245-52. 2007
    ....
  57. pmc Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis
    Christopher P Baran
    Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Am J Respir Crit Care Med 176:78-89. 2007
    ..However, little attention is given to the role of the mononuclear phagocyte survival and recruitment factor, macrophage colony-stimulating factor (M-CSF), in pulmonary fibrosis...
  58. ncbi Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitis
    Margaret L Hibbs
    Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, and Department of Medicine, University of Melbourne, Parkville, Australia
    J Immunol 178:6435-43. 2007
    ..Due to severe osteopetrosis, G-/-GM-/-M-/- mice show diminished numbers of myeloid cells, myeloid progenitors, and B lymphocytes in the ..
  59. pmc Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons
    Yoichi Kondo
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Neuroinflammation 4:31. 2007
    ..The purpose of these studies was to confirm this and to determine if the lack of CSF-1 affects the development of dopaminergic neurons and the expression of CD200, a known microglial inhibitory protein...
  60. pmc Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells
    Keisuke Oguma
    Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    EMBO J 27:1671-81. 2008
    ..These results suggest that macrophage-derived TNF-alpha promotes Wnt/beta-catenin signalling through inhibition of GSK3beta, which may contribute to tumour development in the gastric mucosa...
  61. pmc M-CSF elevates c-Fos and phospho-C/EBPalpha(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification
    Graham D Jack
    Division of Pediatric Oncology, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
    Blood 114:2172-80. 2009
    ....
  62. pmc CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice
    Julia Menke
    Laboratory of Molecular Autoimmune Disease, Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 119:2330-42. 2009
    ..Taken together, these data suggest that CSF-1 mediates renal repair by both a macrophage-dependent mechanism and direct autocrine/paracrine action on TECs...
  63. doi Transcriptional effects of colony-stimulating factor-1 in mouse macrophages
    Carol El Chartouni
    Department of Hematology and Oncology, University Hospital, University of Regensburg, 93042 Regensburg, Germany
    Immunobiology 215:466-74. 2010
    ..These motifs showed a strong positional preference on target promoters at -60, -30 and 0 bp upstream of the transcription start site, and define the common promoter structure of CSF-1-responsive genes...
  64. doi Liver regeneration is impaired in macrophage colony stimulating factor deficient mice after partial hepatectomy: the role of M-CSF-induced macrophages
    Hidetake Amemiya
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    J Surg Res 165:59-67. 2011
    ..Thus, M-CSF-induced hepatic macrophages play an important role in liver regeneration after PH...
  65. pmc Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas
    Aaron M Bender
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 70:3557-65. 2010
    ..Insertions in the growth factor gene Csf1 were found in 13 of the 21 tumors (62%), clustered in introns 5 and 8...
  66. pmc Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells
    Suwen Wei
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Leukoc Biol 88:495-505. 2010
    ..in a CSF-1-dependent manner in vivo, rescued the bone, osteoclast, tissue macrophage, and fertility defects of Csf1(op)/(op) mice, suggesting similar regulation of CSF-1R-expressing cells by IL-34 and CSF-1...
  67. doi Efficient differentiation and function of human macrophages in humanized CSF-1 mice
    Chozhavendan Rathinam
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    Blood 118:3119-28. 2011
    ..Insertion of human CSF1 into the corresponding mouse locus of Balb/c Rag2(-/-) γc(-/-) mice through VELOCIGENE technology resulted in ..
  68. doi Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development
    S M Pyonteck
    Cancer Biology and Genetics Program, New York, NY, USA
    Oncogene 31:1459-67. 2012
    ..crossed the RIP1-Tag2 (RT2) mouse model of pancreatic islet cancer to colony-stimulating factor-1 (CSF-1)-deficient Csf1(op/op) mice, which have reduced numbers of tissue macrophages...
  69. pmc Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1
    Elisa Tagliani
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 208:1901-16. 2011
    ..Together, these data provide cellular and molecular insight into the regulation of Mφ tissue densities under noninflammatory conditions and reveal a central role for CSF-1 in the coordination of Mφ and DC homeostasis...
  70. pmc Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits
    Bryna Erblich
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 6:e26317. 2011
    ..survive to adulthood and therefore to study the role of CSF-1R in olfaction we used the viable null mutants in the Csf1 (Csf1(op)) gene that encodes one of the two known CSF-1R ligands...
  71. pmc Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling
    Salvatore J Coniglio
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Med 18:519-27. 2012
    ....
  72. pmc The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1
    Heli Liu
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Biochim Biophys Acta 1824:938-45. 2012
    ..negative cooperativity of CSF-1 at the receptor-recognition sites, in combination with the difference in hydrophobicity which dictates a more stable IL-34:CSF-1R complex compared to the CSF-1:CSF-1R complex...
  73. pmc Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
    Jian Luo
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 210:157-72. 2013
    Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the CSF1 receptor (CSF1R) and thus are key regulators of the monocyte/macrophage lineage...
  74. pmc CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response
    Duy Huynh
    Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    PLoS ONE 8:e56951. 2013
    ..Colons from Csf1r null and Csf1(op/op) mice were isolated and sectioned for IHC identification of enterocytes, enteroendocrine cells, goblet cells ..
  75. ncbi Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma
    A Nowicki
    Department of Immunology, Central Clinical Hospital, Military School of Medicine, Warsaw, Poland
    Int J Cancer 65:112-9. 1996
    ..Our data suggest that the CSF-1-dependent macrophage subpopulation missing in op/op mice plays a primary role in supporting tumor stroma formation and tumor vascularization in murine LLC tumors...
  76. ncbi Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells
    S Murase
    Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Neurosci 18:10481-92. 1998
    ..Therefore, c-fms is considered to be a new developmental marker for Purkinje cells...
  77. ncbi Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1
    R Tedjo Sasmono
    CRC for Chronic Inflammatory Diseases and ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    J Leukoc Biol 82:111-23. 2007
    ..In keeping with this hypothesis, we showed that purified Ly-6G-positive granulocytes express CSF-1R after overnight culture and can subsequently differentiate to form F4/80-positive macrophages in response to CSF-1...
  78. pmc cDNA cloning and expression of murine macrophage colony-stimulating factor from L929 cells
    M B Ladner
    Department of Molecular Biology, Cetus Corp, Emeryville, CA 94608
    Proc Natl Acad Sci U S A 85:6706-10. 1988
    ..Both clones can be expressed in COS cells and the recombinant protein is active in a mouse bone marrow colony assay...
  79. ncbi Effects of macrophage colony-stimulating factor (M-CSF) on the development, differentiation, and maturation of marginal metallophilic macrophages and marginal zone macrophages in the spleen of osteopetrosis (op) mutant mice lacking functional M-CSF activi
    K Takahashi
    Second Department of Pathology, Kumamoto University School of Medicine, Japan
    J Leukoc Biol 55:581-8. 1994
    ..Although the marginal metallophilic macrophages and marginal zone macrophages are thought to be M-CSF-dependent, their development and differentiation appear to be influenced by locally produced M-CSF or other cytokines...
  80. ncbi The predominant form of secreted colony stimulating factor-1 is a proteoglycan
    L K Price
    Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 267:2190-9. 1992
    ....
  81. ncbi Colony stimulating factor 1 (CSF-1) and its in vivo role as delineated using osteopetrotic op/op mice
    W Wiktor-Jedrzejczak
    Department of Immunology, Central Clinical Hospital, Military School of Medicine, Warsaw, Poland
    Postepy Biochem 37:54-7. 1991
  82. ncbi The murine M-CSF gene is localized on chromosome 3
    S Gisselbrecht
    Institut National de la Santé et de la Recherche Médicale U152, Hopital Cochin, Paris, France
    Blood 73:1742-5. 1989
  83. pmc Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA
    T B Rajavashisth
    Proc Natl Acad Sci U S A 84:1157-61. 1987
    ..5-kb and 1.4-kb species, and intestine lacked detectable CSF-1 transcripts. Southern blot analysis suggests that the CSF-1 gene is present as a single copy in the mouse haploid genome and that it is not rearranged or amplified in L cells...
  84. pmc Induction of clonal monocyte-macrophage tumors in vivo by a mouse c-myc retrovirus: rearrangement of the CSF-1 gene as a secondary transforming event
    W R Baumbach
    Mol Cell Biol 7:664-71. 1987
    ..The pleiotropy of phenotypes among the other tumors indicated that there are a variety of other mechanisms for such secondary events which can be investigated with this system...
  85. pmc Transgenic mice in the study of cytokine function
    J Taverne
    University College London Medical School, Department of Immunology, UK
    Int J Exp Pathol 74:525-46. 1993
  86. pmc The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor
    K Carlberg
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Mol Biol Cell 5:81-95. 1994
    ....
  87. ncbi IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein
    E U Sarmiento
    Department of Immunology Microbiology, Rush Medical College, Chicago, IL 60612, USA
    J Immunol 155:2211-21. 1995
    ..These results indicate that IL-3, IL-5, and GM-CSF may contribute to the pathogenesis of allergic and other disorders characterized by eosinophilia in part through potentiation of basophil mediator release stimulated by MBP...
  88. ncbi Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E
    W J de Villiers
    Sir William Dunn School of Pathology, University of Oxford, UK
    Arterioscler Thromb Vasc Biol 18:631-40. 1998
    ..This may explain preservation of SR-A activity in these animals. Our findings clearly illustrate the importance of both M-CSF and M-CSF-dependent monocytes/Mphis in maintaining cholesterol homeostasis and in atherogenesis...
  89. ncbi Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice
    Martine M L Deckers
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, The Netherlands
    J Bone Miner Res 17:998-1007. 2002
    ..On the other hand, our results confirm that bisphosphonates can be used safely in the treatment of disorders that affect the growing skeleton, such as in juvenile osteoporosis...
  90. ncbi Metallothionein is required for zinc-induced expression of the macrophage colony stimulating factor gene
    Masako Kanekiyo
    Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    J Cell Biochem 86:145-53. 2002
    ..Moreover, overexpression of MT upregulated M-CSF mRNA expression as well as M-CSF secretion. Our findings suggest that MT expression mediates zinc regulation of M-CSF gene expression at the transcriptional level...
  91. ncbi Cellular and molecular mechanisms underlying LPS-associated myocyte impairment
    Samantha A Tavener
    Dept of Physiology and Biophysics, Univ of Calgary Medical Centre, AB, Canada
    Am J Physiol Heart Circ Physiol 290:H800-6. 2006
    ..These data suggest that macrophages and to a lesser degree neutrophils cause cardiac impairment, presumably via TNF-alpha...
  92. ncbi Macrophage colony stimulating factor is a crucial factor for the intrinsic macrophage response in mice heterozygously deficient for the myelin protein P0
    Marcus Müller
    Department of Neurology, University of Munster, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Exp Neurol 203:55-62. 2007
    ..chimeric mice by transplanting GFP+ bone marrow into P0 mutants (P0+/-) and P0 mutants that lack M-CSF (P0+/- mcsf-op)...
  93. pmc Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
    Elaine Y Lin
    Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women s Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Oncol 1:288-302. 2007
    ..This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion...
  94. doi IL-4 blocks M-CSF-dependent macrophage proliferation by inducing p21Waf1 in a STAT6-dependent way
    Luis Arpa
    Institute for Research in Biomedicine, University of Barcelona, Barcelona, Spain
    Eur J Immunol 39:514-26. 2009
    ..Thus, IL-4 and IFN-gamma blocked M-CSF-induced macrophage proliferation through distinct mechanisms...
  95. pmc VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
    Tuomas Tammela
    Molecular Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Research Programs Unit and Department of Pathology, Haartman Institute, Biomedicum Helsinki, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Nat Cell Biol 13:1202-13. 2011
    ..These results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts...
  96. pmc Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization
    Kana Miyamoto
    Department of Orthopedic Surgery, Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Exp Med 208:2175-81. 2011
    ..These results suggest that osteoclasts are dispensable for HSC mobilization and may function as negative regulators in the hematopoietic system...
  97. pmc Nucleotide sequence of a cDNA encoding murine CSF-1 (Macrophage-CSF)
    J F DeLamarter
    Nucleic Acids Res 15:2389-90. 1987
  98. ncbi Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine
    J B Smith
    Division of Neonatology, UCLA School of Medicine 90095, USA
    J Biol Chem 270:16756-65. 1995
    ..Seven were previously known. Six of these encode intercellular mediators (thrombospondin-1, MCSF, JE/MCP-1, MARC/fic/MCP-3, crg2/IP-10, and cyr61); one encodes a protein of unknown function (IRG2)...
  99. ncbi The biology and action of colony stimulating factor-1
    E R Stanley
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York
    Stem Cells 12:15-24; discussion 25. 1994
    ..Several have been identified and the behavior of one of them, protein tyrosine phosphatase 1C (PTP1C), is discussed...
  100. ncbi Colony-stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) mice
    K T Sundquist
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA
    Bone 16:39. 1995
    ..High CSF-1 gene expression occurs at bone modeling sites, co-localizes with osteoblasts, and temporally correlates with their differentiation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  101. ncbi Cloning and expression of unique murine macrophage colony-stimulating factor transcripts
    K Pogue-Geile
    Department of Radiation Oncology, University of Pittsburgh Medical Center, PA, USA
    Blood 85:3478-86. 1995
    ....

Research Grants10

  1. EINSTEIN TRANSGENIC AND GENE TARGETING COURSE
    Jeffrey Pollard; Fiscal Year: 2004
    ..Considerable emphasis in placed upon these interactions so that experimental procedures can be developed by the students in the future that address specific human diseases particularly cancer. ..
  2. CSF-1, MACROPHAGES AND MALE REPRODUCTIVE FUNCTION
    Jeffrey Pollard; Fiscal Year: 2001
    ..Furthermore, the hypothalamic- pituitary feedback loop to T is lost in these mice. The steroidogenic function of csfm/op Leydig cells can be restored by LH and, in turn, LH release can be induced in vivo by a GnRH agonist...
  3. Discovery and functional assessment of the rat op gene
    DAVID DOBBINS; Fiscal Year: 2004
    ..b>Osteopetrosis is caused by a heterogeneous group of congenital bone diseases that are characterized by a generalized ..
  4. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
    ..abstract_text> ..
  5. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2006
    ..Understanding the mechanistic basis of the macrophage enhancement of metastasis could result in the development of novel therapeutics aimed at to prevent this step. ..
  6. 2006 Reproductive Tract Biology Gordon Research Conference
    Jeffrey Pollard; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  7. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  8. Progesterone Action in the Uterus of Mice and Humans
    Jeffrey Pollard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. CSF-1 GENE EXPRESSION IN OSTEOCLAST BIOLOGY
    SHERRY ABBOUD WERNER; Fiscal Year: 2009
    ..address this issue, we will use a knock-out and high throughput knock-in approach to selectively express sCSF-1 or mCSF-1 in mice and examine their effect in collagen-induced arthritis (CIA), a model that mimics the human counterpart ..
  10. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009
    ..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..