Genomes and Genes
Gene Symbol: Crb1
Description: crumbs family member 1, photoreceptor morphogenesis associated
Alias: 7530426H14Rik, A930008G09Rik, protein crumbs homolog 1, crumbs homolog 1
- Ccl2/Cx3cr1 knockout mice have inner retinal dysfunction but are not an accelerated model of AMDKirstan A Vessey
Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, Australia
Invest Ophthalmol Vis Sci 53:7833-46. 2012..recent reports indicate that this ascribed phenotype is due to the presence of a retinal degeneration mutation (crb1(rd8/rd8), rd8) on the background strain...
- The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factorsUlrich F O Luhmann
Department of Genetics and
Hum Mol Genet 24:128-41. 2015Understanding phenotype-genotype correlations in retinal degeneration is a major challenge. Mutations in CRB1 lead to a spectrum of autosomal recessive retinal dystrophies with variable phenotypes suggesting the influence of modifying ..
- Rd8 mutation in the Crb1 gene of CD11c-eYFP transgenic reporter mice results in abnormal numbers of CD11c-positive cells in the retinaXiangting Chen
Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia
J Neuropathol Exp Neurol 72:782-90. 2013..confirmed that the cause of the retinal dystrophic lesions in CD11c-eYFP transgenic mice was the occurrence of the Crb1(rd8) mutation, which affects all mice of the C57BL/6N strain but not the C57BL/6J strain...
- Survey of common eye diseases in laboratory mouse strainsBo Chang
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Invest Ophthalmol Vis Sci 54:4974-81. 2013..These eye diseases are retinal degeneration 1 (Pde6b(rd1)), retinal degeneration 8 (Crb1(rd8)), and cone photoreceptor function loss 3 (Gnat2(cpfl3)).
- Repair of the degenerate retina by photoreceptor transplantationAmanda C Barber
Department of Genetics, University College London Institute of Ophthalmology, London EC1V 9EL, United Kingdom
Proc Natl Acad Sci U S A 110:354-9. 2013..Integration can increase (Prph2(+/Δ307)), decrease (Crb1(rd8/rd8), Gnat1(-/-), Rho(-/-)), or remain constant (PDE6β(rd1/rd1), Prph2(rd2/rd2)) with disease progression, ..
- Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degenerationUlrich F O Luhmann
Department of Genetics, UCL Institute of Ophthalmology, 11 43 Bath Street, EC1V9EL London, United Kingdom
Exp Eye Res 107:80-7. 2013..All mouse lines are derived from common parental strains and do not carry the homozygous rd8 mutation in the Crb1 gene that has been a major confounding factor in previous reports...
- The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypesMary J Mattapallil
Laboratory of Immunology, National Eye Institute, Bethesda, Maryland, USA
Invest Ophthalmol Vis Sci 53:2921-7. 2012..We set out to examine the prevalence of this mutation in induced mutant mouse lines, vendor C57BL/6 mice and in widely used embryonic stem cells...
- Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosisSeo Hee Cho
Pediatric Research Center, Department of Pediatrics, University of Texas Health Science Center, Houston TX 77030, USA
Hum Mol Genet 21:2663-76. 2012Mutation of the polarity gene Crumbs homolog 1 (CRB1) is responsible for >10% of Leber congenital amaurosis (LCA) cases worldwide; LCA is characterized by early-onset degenerative retinal dystrophy...
- Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse modelTomas S Aleman
Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Invest Ophthalmol Vis Sci 52:6898-910. 2011To investigate the human disease due to CRB1 mutations and compare results with the Crb1-mutant rd8 mouse.
- Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomographyM Dominik Fischer
Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
PLoS ONE 4:e7507. 2009..Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration...
- Crb1 is a determinant of retinal apical Müller glia cell featuresSerge A van de Pavert
Department of Neuromedical Genetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
Glia 55:1486-97. 2007Mutations in the human Crumbs homologue-1 (CRB1) gene cause retinal blinding diseases, such as Leber congenital amaurosis and retinitis pigmentosa...
- Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12)A I den Hollander
Department of Human Genetics, University Hospital Nijmegen, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Nat Genet 23:217-21. 1999..This protein is homologous to the Drosophila melanogaster protein crumbs (CRB), and denoted CRB1 (crumbs homologue 1)...
- Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brainAnneke I den Hollander
Department of Human Genetics, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Mech Dev 110:203-7. 2002Mutations in the human Crumbs homologue 1 (CRB1) gene cause severe retinal dystrophies. CRB1 is homologous to Drosophila Crumbs, a protein essential for establishing and maintaining epithelial polarity...
- Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesisMilena Pellikka
Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
Nature 416:143-9. 2002..Loss-of-function mutations in the human homologue of Crumbs, CRB1 (RP12), cause recessive retinal dystrophies, including retinitis pigmentosa...
- CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retinaAdrienne K Mehalow
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Hum Mol Genet 12:2179-89. 2003Mutations within the CRB1 gene have been shown to cause human retinal diseases including retinitis pigmentosa and Leber congenital amaurosis...
- Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposureSerge A van de Pavert
The Netherlands Ophthalmic Research Institute, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
J Cell Sci 117:4169-77. 2004Loss of Crumbs homologue 1 (CRB1) function causes either the eye disease Leber congenital amaurosis or progressive retinitis pigmentosa, depending on the amount of residual CRB1 activity and the genetic background...
- Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cellsAgnes G S H van Rossum
Department of Neuromedical Genetics, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
Hum Mol Genet 15:2659-72. 2006Mutations in the human Crumbs homologue-1 (CRB1) gene cause retinal diseases including Leber's congenital amaurosis (LCA) and retinitis pigmentosa type 12...
- A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1Serge A van de Pavert
Department of Neuromedical Genetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands
J Neurosci 27:564-73. 2007Different mutations in the human Crumbs homolog-1 (CRB1) gene cause a variety of retinal dystrophies, such as Leber congenital amaurosis, early onset retinitis pigmentosa (e.g...
- Towards understanding CRUMBS function in retinal dystrophiesMélisande Richard
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
Hum Mol Genet 15:R235-43. 2006Mutations in the Crumbs homologue 1 (CRB1) gene cause autosomal recessive retinitis pigmentosa (arRP) and autosomal Leber congenital amaurosis (arLCA)...
- Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse modelBhubanananda Sahu
Shiley Eye Institute, University of California San Diego, La Jolla, CA
Mol Vis 21:273-84. 2015A spontaneous frameshift mutation, c.3481delC, in the Crb1 gene is the underlying cause of dysplasia and retinal degeneration in rd8 mice. The rd8 mutation is found in C57BL/6N but not in C57BL/6J mouse sub-strains...
- Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature RetinaXu Wang
Unit on Neuron Glia Interactions in Retinal Disease
J Neurosci 36:2827-42. 2016..Our findings on constitutive microglial function are relevant in understanding microglial contributions to pathology and in the consideration of therapeutic interventions that reduce or perturb constitutive microglial function...
- Alkylglycerone phosphate synthase (AGPS) deficient mice: models for rhizomelic chondrodysplasia punctate type 3 (RCDP3) malformation syndromeRyan P Liegel
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI
Mol Genet Metab Rep 1:299-311. 2014....
- A comparative analysis of C57BL/6J and 6N substrains; chemokine/cytokine expression and susceptibility to laser-induced choroidal neovascularizationGloriane Schnabolk
Research Service, Ralph H Johnson VA Medical Center, Charleston, SC 29401, USA
Exp Eye Res 129:18-23. 2014..In particular, the rd8 mutation of the Crb1 gene present in the C57BL/6N has been shown to impact certain ocular phenotypes and appears to augment phenotypes ..
- The role of histamine in the retina: studies on the Hdc knockout mouseUrsula Greferath
Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Victoria, Australia
PLoS ONE 9:e116025. 2014..discrete lesions across the retina that corresponded to areas of photoreceptor abnormality reminiscent of the rd8 (Crb1) mutation. This was confirmed after genotyping and the strain designated Hdcrd8/rd8...
- Differences in the distribution, phenotype and gene expression of subretinal microglia/macrophages in C57BL/6N (Crb1 rd8/rd8) versus C57BL6/J (Crb1 wt/wt) miceBogale Aredo
Department of Ophthalmology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 9057, USA
J Neuroinflammation 12:6. 2015..Our goal was to study the spatial and temporal distribution, the phenotype, and gene expression of subretinal MG/MΦ in mice with normal retinas and compare them to mice with known retinal pathology...
- Methodologies for analysis of patterning in the mouse RPE sheetJeffrey H Boatright
Department of Ophthalmology, Emory University, Atlanta, GA
Mol Vis 21:40-60. 2015....
- Assessment of retinal function and morphology in aging Ccl2 knockout miceKirstan A Vessey
Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Australia
Invest Ophthalmol Vis Sci 56:1238-52. 2015..We sought to correlate changes in retinal pigment epithelium (RPE) and retinal morphology with changes in function in aging Ccl2(-/-) mice...
- Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domainsJoaquim Grego-Bessa
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Development 142:1305-14. 2015..The basal accumulation of F-actin is associated with the assembly of ectopic basal tight junctions and focal disruptions of the basement membrane, which eventually lead to a breakdown of epithelial organization...
- Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specificClaire Hippert
Department of Genetics, University College London Institute of Ophthalmology, 11 43 Bath Street, London, EC1V 9EL, United Kingdom
PLoS ONE 10:e0120415. 2015..Together, these results show that gliosis and its associated processes are variable and disease-dependent. ..
- Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular PermeabilityNori Nagai
Department of Ocular Biology and Therapeutics, University College London Institute of Ophthalmology, London, United Kingdom
Am J Pathol 185:2534-49. 2015..The findings also demonstrate that systemic exposure to CCR3 antagonists may be crucial for CNV-targeted activity. ..
- A case of mistaken identity: CD11c-eYFP(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cellsSamantha J Dando
Department of Anatomy and Developmental Biology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia
Glia 64:1331-49. 2016..We previously showed that these mice carry the Crb1(rd8) mutation, which causes retinal dystrophic lesions; therefore we hypothesized that the presence of CD11c-eYFP(+)..
- Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndromePoppy Datta
Department of Ophthalmology and Visual Sciences, University of Iowa College of Medicine, Iowa City, IA 52242
Proc Natl Acad Sci U S A 112:E4400-9. 2015..Our data also suggest that a major function of BBS proteins in photoreceptors is to transport proteins from the OS to the cell body or to prevent entry of non-OS proteins into the OS. ..
- Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with agePhilipp Herrmann
Department of Genetics, UCL Institute of Ophthalmology, London, UK
Neurobiol Aging 36:2637-48. 2015..This data emphasizes the particular vulnerability of the RPE-choroidal complex to dysregulation of the alternative complement pathway during aging...
- Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalonJacobus J Dudok
Department of Neuromedical Genetics, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
Neurosci Res 108:12-23. 2016..We examined the physiological function of Crb2 on wild type genetic background as well as on background lacking Crb1. Telencephalon lacking CRB2 resulted in reduced levels of PALS1 and CRB3 from the apical complex, an increased ..
- Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eyeJin Young Kim
Shriners Hospitals Pediatric Research Center Center for Neural Repair and Rehabilitation and Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, United States
Dev Biol 419:336-347. 2016....
- Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2Nitya Ramkumar
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Program in Biochemistry and Structural Biology, Cell and Developmental Biology, and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America
PLoS Genet 11:e1005551. 2015....
- Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulationNitya Ramkumar
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Nat Cell Biol 18:1281-1291. 2016....
- The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutationJoseph S Pak
Mary D Allen Laboratory for Vision Research, USC Eye Institute, Departments of Ophthalmology and Cell and Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA
Mol Vis 21:1281-94. 2015..One of these strains, the commonly used C57BL/6N (B6N), was discovered to carry a point mutation in the Crumbs homolog 1 (Crb1(rd8) ) gene, which codes for a developmental protein involved in tight junction formation at the outer ..
- Fundus autofluorescence and photoreceptor cell rosettes in mouse modelsErin Flynn
Department of Ophthalmology, Columbia University, New York, New York, United States
Invest Ophthalmol Vis Sci 55:5643-52. 2014..This study was conducted to study correlations among fundus autofluorescence (AF), RPE lipofuscin accumulation, and photoreceptor cell degeneration and to investigate the structural basis of fundus AF spots...
- Crumbs3 is essential for proper epithelial development and viabilityEileen L Whiteman
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Mol Cell Biol 34:43-56. 2014..Taken together, our data indicate that Crumbs3 is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytoskeleton. ..
- Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic backgroundCelso Henrique Alves
Department of Neuromedical Genetics, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
PLoS ONE 8:e82532. 2013In humans, the Crumbs homologue-1 (CRB1) gene is mutated in progressive types of autosomal recessive retinitis pigmentosa and Leber congenital amaurosis...
- Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosisLucie P Pellissier
Department of Neuromedical Genetics, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
PLoS Genet 9:e1003976. 2013..Here, we report that ablation of Crb1 and Crb2 genes results in severe impairment of retinal function, abnormal lamination and thickening of the retina ..
- Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repairBenjamin E Low
The Jackson Laboratory, Bar Harbor, Maine
Invest Ophthalmol Vis Sci 55:387-95. 2014We directly corrected the mouse Crb1(rd8) gene mutation, which is present in many inbred laboratory strains derived from C57BL/6N and complicates genetic studies of retinal disease in mice.
- CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in miceLucie P Pellissier
Department of Neuromedical Genetics
Hum Mol Genet 23:3759-71. 2014Mutations in the CRB1 gene lead to retinal dystrophies ranging from Leber congenital amaurosis (LCA) to early-onset retinitis pigmentosa (RP), due to developmental defects or loss of adhesion between photoreceptors and Müller glia cells, ..
- RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularizationMei Chen
Centre for Experimental Medicine, Queen s University of Belfast, Belfast, United Kingdom
PLoS ONE 9:e89548. 2014..This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macular degeneration (nvAMD)...
- CCL3 production by microglial cells modulates disease severity in murine models of retinal degenerationHideo Kohno
Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106
J Immunol 192:3816-27. 2014..Taken together, our results indicate that Ccl3 has an essential role in regulating the severity of retinal inflammation and degeneration in these mouse models. ..
- Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degenerationYujuan Wang
1 Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA 2 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
Lab Invest 94:674-82. 2014..survival and antiapoptotic effects of PDGF-C on focal retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) on C57BL/6N [Crb1(rd8)] (DKO rd8) background mice, a model for progressive and focal retinal degeneration...
- Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degenerationDaniel Ardeljan
Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 9:e95900. 2014..This intervention rescues RPE and photoreceptors in a MAPK-dependent process. The IL17 pathway plays a key role in RPE and photoreceptor degeneration and could hold therapeutic potential in AMD. ..
- Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunctionNorihiro Nagai
Department of Ocular Biology and Therapeutics, University College London, Institute of Ophthalmology, London, United Kingdom
Invest Ophthalmol Vis Sci 55:3709-19. 2014..Characterization of a mouse model of spontaneous choroidal neovascularization (sCNV) and its effect on retinal architecture and function...
- A mouse model for studying cone photoreceptor pathologiesMarijana Samardzija
Laboratory for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland
Invest Ophthalmol Vis Sci 55:5304-13. 2014..To develop a model with a functional all-cone retina that is morphologically well structured, we generated R91W;Nrl(-/-) double-mutant mice, which express a hypomorphic Rpe65 allele (R91W)...
- Autophagy protects the retina from light-induced degenerationYu Chen
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 288:7506-18. 2013..Taken together, these observations provide novel evidence implicating an important role of autophagy and mitophagy in protecting the retina from all-trans-retinal- and light-induced degeneration...
- Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumptionGuy A Perkins
National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, USA
Mol Vis 18:3029-48. 2012..Thus, our experiments investigated the structural and functional effects of environmentally relevant postnatal lead exposure on rod spherule and cone pedicle mitochondria and whether Bcl-xL overexpression provided neuroprotection...
- Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganizationNing Zhang
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44160, USA
J Clin Invest 123:121-37. 2013..Additionally, these results suggest that patients heterozygous for the E150K mutation should be periodically reevaluated for delayed-onset retinal degeneration...
- Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cellsJ Lakowski
Developmental Biology Unit, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK
Hum Mol Genet 19:4545-59. 2010..transplantation into the wild-type and degenerating retina of two genetic models of Leber congenital amaurosis, the Crb1(rd8/rd8) and Gucy2e(-/-) mouse...
- GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectorsWendy M Aartsen
Department of Neuromedical Genetics, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
PLoS ONE 5:e12387. 2010..Because activated Müller glial cells span the entire retina and align areas of injury, they are ideal targets for therapeutic strategies, including gene therapy...
- Composition and function of the Crumbs protein complex in the mammalian retinaIlse Gosens
Department of Human Genetics and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
Exp Eye Res 86:713-26. 2008..Mutations in the gene encoding human CRB1, the first one identified out of the three human orthologs, have been associated with a number of retinal ..
- The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryoJeffrey D Lee
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Development 134:2007-16. 2007..We propose that mouse Lulu (Epb4.1l5) helps anchor the actin-myosin contractile machinery to the membrane to allow the dynamic rearrangements of epithelia that mediate embryonic morphogenesis...
- Expression of a novel secretory form (Crb1s) of mouse Crumbs homologue Crb1 in skin developmentTatsuya Watanabe
Department of Molecular Physiology, Kyoritsu University of Pharmacy, 1 5 30 Shiba koen, Minatoku, Tokyo 105 8512, Japan
Biochem Biophys Res Commun 313:263-70. 2004..We cloned a novel variant of mouse Crb1 and termed it Crb1s...
- Retinal degeneration mutants in the mouseB Chang
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA
Vision Res 42:517-25. 2002..cpfl1 mice may provide a model for congenital achromatopsia in humans...
- Genetics of Age-Related CataractsBo Chang; Fiscal Year: 2007..abstract_text> ..