Crabp1

Summary

Gene Symbol: Crabp1
Description: cellular retinoic acid binding protein I
Alias: AI326249, CRABP-I, Crabp-1, CrabpI, Rbp-5, cellular retinoic acid-binding protein 1
Species: mouse

Top Publications

  1. pmc Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos
    Ann V Griffith
    Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Dev Biol 327:216-27. 2009
  2. pmc Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice
    H Yanagisawa
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    J Clin Invest 102:22-33. 1998
  3. ncbi Two rhombomeres are altered in Hoxa-1 mutant mice
    M Mark
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Development 119:319-38. 1993
  4. ncbi Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis
    E Ruberte
    Laboratoire de Genetique Moleculaire des Eucaryotes, CNRS, U 184 de Biologie Moléculaire et de Génie Génétique, INSERM, Faculte de Medecine, Strasbourg, France
    Development 115:973-87. 1992
  5. ncbi Domains of cellular retinoic acid-binding protein I (CRABP I) expression in the hindbrain and neural crest of the mouse embryo
    M Maden
    Developmental Biology Research Centre, King s College London, U K
    Mech Dev 37:13-23. 1992
  6. ncbi Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos
    E Ruberte
    Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS Unité 184 de Biologie Moléculaire et de Génie Génétique de l INSERM, Strasbourg, France
    Development 111:45-60. 1991
  7. ncbi Mouse cellular retinoic acid binding protein: cloning, complementary DNA sequence, and messenger RNA expression during the retinoic acid-induced differentiation of F9 wild type and RA-3-10 mutant teratocarcinoma cells
    C M Stoner
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts
    Cancer Res 49:1497-504. 1989
  8. ncbi Anteriorization of CRABP-I expression by retinoic acid in the developing mouse central nervous system and its relationship to teratogenesis
    L Leonard
    Developmental Biology Research Centre, King s College London, United Kingdom
    Dev Biol 168:514-28. 1995
  9. ncbi Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo
    C Horton
    Developmental Biology Research Centre, King s College London, United Kingdom
    Dev Dyn 202:312-23. 1995
  10. ncbi Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Cell 75:1199-214. 1993

Scientific Experts

  • Rosalba Parenti
  • Alexander R Moise
  • Laina Freyer
  • Valérie Dupé
  • Vesna Todorovic
  • Karine Rizzoti
  • Pontus C Holm
  • Francesca Amati
  • Juan Pedro Martinez Barbera
  • Li na Wei
  • Tatsuo Furuyama
  • Huiping Zhu
  • Michelle A Lane
  • A L Gustafson
  • Frank G Schaap
  • Robert G Kelly
  • Karen Niederreither
  • Subreena Simrick
  • Karim Mesbah
  • Pierre Chambon
  • Julien Vermot
  • Tadashi Okubo
  • Zachary Harrelson
  • Virginia E Papaioannou
  • P Chambon
  • Timothy J Mead
  • Elik Chapnik
  • Xiuxia Qu
  • Pavel Kirilenko
  • Pablo Villavicencio-Lorini
  • M Albert Basson
  • Robin D Clugston
  • R Krumlauf
  • Ann V Griffith
  • Victoria Randall
  • Francesca Rochais
  • Pascal Dolle
  • A Gavalas
  • G B Mulder
  • Charlotte A Collins
  • Takahiro Sato
  • Marion A Cooley
  • P Dolle
  • Isabelle Anselme
  • J Robert Schleiffarth
  • Matthew M Goddeeris
  • Zhen Zhang
  • Andrei Molotkov
  • Anita Marguerie
  • Stephen A Murray
  • Takako Makita
  • I Washington Smoak
  • Antonio Baldini
  • Byeong Moo Kim
  • Stephane D Vincent
  • Nicolas Matt
  • Erik N Meyers
  • Huansheng Xu
  • Sophie Remacle
  • Lora L Burns-Hamuro
  • Nina Trokovic
  • Lindsay F Fowles
  • Jinghua Zhang
  • Elva Diaz
  • Shinji Takada
  • Brigitte Schuhbaur
  • Radwan Abu-Issa
  • V Sapin
  • M Rossel
  • A Lumsden
  • Christian Carbe
  • Andrea Powers
  • Yi Pan
  • Robert Blelloch
  • Katherine E Yutzey
  • S Daujat
  • N Watari
  • Eran Hornstein
  • Xin Zhang
  • Vered Sasson
  • S Vogel
  • Kay Grobe
  • Guiyuan He
  • Richard Jones
  • Heiko Lickert
  • Baljinder S Mankoo
  • Nicoletta Bobola
  • P Trainor
  • Moises Mallo
  • J P Golding

Detail Information

Publications109 found, 100 shown here

  1. pmc Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos
    Ann V Griffith
    Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Dev Biol 327:216-27. 2009
    ....
  2. pmc Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice
    H Yanagisawa
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    J Clin Invest 102:22-33. 1998
    ..This study demonstrates that ET-1/ETA-mediated signaling plays an essential role in a complex process of aortic arch patterning by affecting the postmigratory cardiac neural crest cell development...
  3. ncbi Two rhombomeres are altered in Hoxa-1 mutant mice
    M Mark
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Development 119:319-38. 1993
    ..The first three of these rhombomeres appear normal as judged from the distribution pattern of CRABPI transcripts in the neurectoderm and from the histological analysis of the cranial nerve components derived from ..
  4. ncbi Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis
    E Ruberte
    Laboratoire de Genetique Moleculaire des Eucaryotes, CNRS, U 184 de Biologie Moléculaire et de Génie Génétique, INSERM, Faculte de Medecine, Strasbourg, France
    Development 115:973-87. 1992
    ..The CRABP I transcript distribution correlates well with structures known to be targets of excess retinoid-induced ..
  5. ncbi Domains of cellular retinoic acid-binding protein I (CRABP I) expression in the hindbrain and neural crest of the mouse embryo
    M Maden
    Developmental Biology Research Centre, King s College London, U K
    Mech Dev 37:13-23. 1992
    We describe here the distribution of cellular retinoic acid-binding protein I (CRABP I) in the head of the early mouse embryo from day 8 to day 13 of gestation, using both in situ hybridisation to localise mRNA and immunocytochemistry to ..
  6. ncbi Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos
    E Ruberte
    Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS Unité 184 de Biologie Moléculaire et de Génie Génétique de l INSERM, Strasbourg, France
    Development 111:45-60. 1991
    ..the retinoic acid receptors, RAR-alpha, -beta and -gamma, and the cellular binding proteins for retinoic acid (CRABP I) and retinol (CRBP I), in mouse embryos during the period of early morphogenesis...
  7. ncbi Mouse cellular retinoic acid binding protein: cloning, complementary DNA sequence, and messenger RNA expression during the retinoic acid-induced differentiation of F9 wild type and RA-3-10 mutant teratocarcinoma cells
    C M Stoner
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts
    Cancer Res 49:1497-504. 1989
    ..One interpretation of this result is that there is negative regulation of CRABP mRNA expression, mediated directly or indirectly by the wild type functional CRABP protein, and that this regulation is aberrant in the RA-3-10 cells...
  8. ncbi Anteriorization of CRABP-I expression by retinoic acid in the developing mouse central nervous system and its relationship to teratogenesis
    L Leonard
    Developmental Biology Research Centre, King s College London, United Kingdom
    Dev Biol 168:514-28. 1995
    ..The role that CRABP-I may play in normal development of the hindbrain and in teratogenesis and the similarity of these results to those obtained with various Hox genes are discussed...
  9. ncbi Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo
    C Horton
    Developmental Biology Research Centre, King s College London, United Kingdom
    Dev Dyn 202:312-23. 1995
    ..We then considered whether cellular retinoic acid-binding protein I or II (CRABP I or II) played any role in this response by determining their relative levels in each of the tissues analysed...
  10. ncbi Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Cell 75:1199-214. 1993
    ..We conclude that Krox-20, although not required for the initial delimitation of r3 and r5, plays an important role in the process of segmentation governing hindbrain development...
  11. ncbi The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres
    I J McKay
    Department of Zoology, Oxford University, UK
    Development 120:2199-211. 1994
    ..9), Hoxb-2 (Hox 2.8), Hoxa-3 (Hox 1.5), Hoxd-4 (Hox 4.2) and cellular retinoic-acid binding protein I (CRABP I), it appears that the fundamental defect is a loss of r5 and r6...
  12. ncbi Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
    M Ishibashi
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Genes Dev 9:3136-48. 1995
    ..These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis...
  13. ncbi Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
    M Studer
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 384:630-4. 1996
    ..These results demonstrate that, as a part of its role in maintaining rhombomere identity, Hoxb-1 is involved in controlling migratory properties of motor neurons in the hindbrain...
  14. ncbi Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant
    S J Conway
    Division of Cell and Molecular Biology, Institute of Child Health, University of London, UK
    Development 124:505-14. 1997
    ..was not due to down-regulation of Pax3 in neural crest cells, as use of independent neural crest markers, Hoxa-3, CrabpI, Prx1, Prx2 and c-met also revealed a deficiency of migrating cardiac neural crest cells in homozygous embryos...
  15. pmc Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization
    Y Qiu
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 11:1925-37. 1997
    ..Furthermore, mCOUP-TFI possesses vital physiological functions that are distinct from mCOUP-TFII despite of their high degree of homology and extensive overlapping expression patterns...
  16. ncbi Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
    M Rossel
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Development 126:5027-40. 1999
    ....
  17. ncbi Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, CU de Strasbourg, France
    Development 126:5051-9. 1999
    ....
  18. ncbi Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest
    A Gavalas
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 128:3017-27. 2001
    ..Furthermore, they demonstrate that early patterning of the separate components of the pharyngeal arches can proceed independently of neural crest cell migration...
  19. ncbi Hoxa3 regulates integration of glossopharyngeal nerve precursor cells
    N Watari
    Department of Cell and Developmental Biology, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Dev Biol 240:15-31. 2001
    ..In summary, the Hoxa3 gene has crucial roles in ensuring the correct axon projection pattern of all three components of the IXth nerve, i.e., motor neurons and sensory neurons of the proximal and distal ganglia...
  20. ncbi The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 130:2525-34. 2003
    ..Thus, RALDH2 plays a crucial role in producing RA required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm...
  21. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
    ..Furthermore, our data link, for the first time, the function of the secondary heart field to congenital heart disease...
  22. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ....
  23. pmc Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice
    Victoria Randall
    Molecular Medicine Unit, Institute of Child Health, London, United Kingdom
    J Clin Invest 119:3301-10. 2009
    ..We could not rescue PAA morphogenesis by restoring neural crest Chd7 expression. Rather, biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal PAA development...
  24. ncbi Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
    J M Goddard
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City 84112, USA
    Development 122:3217-28. 1996
    ..These animals should therefore provide a useful animal model for these human diseases...
  25. doi Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 135:755-65. 2008
    ..This RMCE-mediated knock-in system can serve as a useful tool for studies on gene functions in craniofacial development...
  26. ncbi Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development
    Nicolas Matt
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Dev Dyn 233:167-76. 2005
    ..Therefore, CRBP1 is required in prenatal life to maintain normal amounts of ROL and to ensure its efficient storage but seems of secondary importance for RA synthesis, at least under conditions of maternal vitamin A sufficiency...
  27. ncbi Mutating the charged residues in the binding pocket of cellular retinoic acid-binding protein simultaneously reduces its binding affinity to retinoic acid and increases its thermostability
    J Zhang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235
    Proteins 13:87-99. 1992
    ..Elimination of the positively-charged pair of amino acids produces a protein that is more thermostable than wild-type CRABP but less effective at ligand-binding...
  28. ncbi Molecular cloning and transcriptional mapping of the mouse cellular retinoic acid-binding protein gene
    L N Wei
    Department of Microbiology Immunology, Chang Gung Medical College, Taiwan, ROC
    DNA Cell Biol 9:471-8. 1990
    ....
  29. pmc Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogenesis
    A V Perez-Castro
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Proc Natl Acad Sci U S A 86:8813-7. 1989
    ..Second, the specific expression of CRABP and CRBP in numerous developing tissues indicates that these proteins may perform specific functions during morphogenesis of a broad variety of embryonic structures...
  30. ncbi Retinoic acid induction of mouse cellular retinoic acid-binding protein-I gene expression is enhanced by sphinganine
    L N Wei
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA
    Mol Cell Endocrinol 111:207-11. 1995
    ..Using a lacZ reporter system, it was determined that a DNA fragment containing a putative AP-1 binding site in the promoter region of CRABP-I gene is required for the up-regulation of CRABP-I gene transcription...
  31. ncbi Localization of CRABP-I and CRABP-II mRNA in the early mouse embryo by whole-mount in situ hybridization: implications for teratogenesis and neural development
    S Lyn
    Division of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada
    Dev Dyn 199:280-91. 1994
    ..Furthermore, the limited ability of CRABP mRNA levels to respond to exogenous retinoids may be a factor in retinoid teratogenicity...
  32. ncbi Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo
    A L Gustafson
    Department of Toxicology, Uppsala University, Sweden
    Development 117:451-60. 1993
    ..did not express detectable levels of CRBP I but instead expressed cellular retinoic acid-binding protein I (CRABP I). Previous results have demonstrated that CRABP I is involved in accumulation of RA in the embryo...
  33. ncbi Changing patterns of the retinoic acid system in the developing retina
    P McCaffrery
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    Dev Biol 158:390-9. 1993
    ..The dorso-ventral asymmetry extends also to the cellular retinoic acid binding protein CRABP I, which first appears in the early differentiating ganglion cells in central retina and in the later embryo shows ..
  34. ncbi Antisense oligonucleotides to CRABP I and II alter the expression of TGF-beta 3, RAR-beta, and tenascin in primary cultures of embryonic palate cells
    P Nugent
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    In Vitro Cell Dev Biol Anim 31:553-8. 1995
    ..Inhibition of endogenous CRABP expression renders MEPM cells less responsive to RA with respect to induction of TGF-beta 3, RAR-beta, and tenascin gene expression.(ABSTRACT TRUNCATED AT 250 WORDS)..
  35. ncbi Wnt signalling required for expansion of neural crest and CNS progenitors
    M Ikeya
    Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
    Nature 389:966-70. 1997
    ..Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS...
  36. ncbi Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4
    J P Golding
    Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Cell Biol 2:103-9. 2000
    ..ErbB4 signalling events within the hindbrain therefore provide patterning information to cranial paraxial mesenchyme that is essential for the proper migration of neural crest cells...
  37. pmc A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse
    N B Akhmedov
    Jules Stein Eye Institute, University of California School of Medicine, Los Angeles, CA 90095 7000, USA
    Proc Natl Acad Sci U S A 97:5551-6. 2000
    ..Our findings demonstrate that mPNR expression is critical for the normal development and function of the photoreceptor cells...
  38. ncbi Evolution of the family of intracellular lipid binding proteins in vertebrates
    Frank G Schaap
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:69-77. 2002
    ..It is speculated that recruitment of an iLBP during evolution of animals enabled the mitochondrial oxidation of long-chain fatty acids...
  39. ncbi Genomic screen for genes involved in mammalian craniofacial development
    Lindsay F Fowles
    Institute for Molecular Bioscience and Special Research Centre for Functional and Applied Genomics, The University of Queensland, QLD 4072 Australia
    Genesis 35:73-87. 2003
    ....
  40. pmc Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche, Médicale Université Louis Pasteur, College de France, BP 10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 100:1763-8. 2003
    ....
  41. pmc Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development
    Zhen Zhang
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 133:3587-95. 2006
    ..Thus, the mesodermal transcription program is not only crucial for cardiovascular development, but is also key in the development and patterning of pharyngeal endoderm...
  42. ncbi Wnt5a is required for cardiac outflow tract septation in mice
    J Robert Schleiffarth
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Res 61:386-91. 2007
    ....
  43. ncbi Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling
    Vesna Todorovic
    Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA
    Development 134:3723-32. 2007
    ..This phenotype reveals a crucial role for Ltbp1L and matrix as extracellular regulators of Tgf-beta activity in heart organogenesis...
  44. pmc Fibulin-1 is required for morphogenesis of neural crest-derived structures
    Marion A Cooley
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Dev Biol 319:336-45. 2008
    ....
  45. doi Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia
    Robin D Clugston
    Department of Physiology, University of Alberta, 524 HMRC, Edmonton, Alberta, T6G 2S2 Canada
    Am J Respir Cell Mol Biol 42:276-85. 2010
    ..This study also yielded a novel experimental model that should prove particularly useful for further studies of CDH...
  46. pmc Hes1 is expressed in the second heart field and is required for outflow tract development
    Francesca Rochais
    Developmental Biology Institute of Marseilles Luminy, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy, Marseille, France
    PLoS ONE 4:e6267. 2009
    ..In order to provide further insight into second heart field development we characterized the insertion site of a transgene expressed in the second heart field and outflow tract as the result of an integration site position effect...
  47. pmc Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation
    Pablo Villavicencio-Lorini
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Clin Invest 120:1994-2004. 2010
    ..These data indicate that Hox genes not only regulate patterning but also directly influence bone formation and the ossification pattern of bones, in part via Runx2...
  48. pmc Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2
    Pavel Kirilenko
    AV Hill Building, The University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 31:1301-8. 2011
    ..Finally, we show that Meox1 can specifically bind the DNA sequences recognized by Hoxa2 on its functional target genes. These results provide new insight into the Hoxa2 regulatory network that controls branchial arch identity...
  49. doi Dgcr8 controls neural crest cells survival in cardiovascular development
    Elik Chapnik
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Dev Biol 362:50-6. 2012
    ..Our data uncover a new role of Dgcr8 in cardiovascular morphogenesis, plausibly as part of transmission mechanism for FGF-dependent survival cue for migrating cNCCs...
  50. pmc Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development
    Xiuxia Qu
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 139:2730-9. 2012
    ..Taken together, these results demonstrate that mesenchymal GAG controls lacrimal gland induction by restricting the diffusion of Fgf10...
  51. doi Pharyngeal arch deficiencies affect taste bud development in the circumvallate papilla with aberrant glossopharyngeal nerve formation
    Tadashi Okubo
    Department of Laboratory Animal Science, Kitasato University School of Medicine, Minami Ku, Sagamihara, Japan
    Dev Dyn 244:874-87. 2015
    ..The developing tongue also has a complex supply of cranial nerves through each PA. However, the relationship between the PAs and taste bud development is not fully understood...
  52. ncbi Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse
    Radwan Abu-Issa
    Department of Pediatrics, Neonatal Perinatal Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 129:4613-25. 2002
    ..This study defines the cardiovascular defects present in Fgf8 mutants and supports a role for Fgf8 in development of all the pharyngeal arches and in NCC survival...
  53. pmc Notch pathway regulation of neural crest cell development in vivo
    Timothy J Mead
    The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Dev Dyn 241:376-89. 2012
    ..The function of Notch signaling in murine neural crest-derived cell lineages in vivo was examined...
  54. ncbi A 3 kb sequence from the mouse cellular retinoic-acid-binding protein gene upstream region mediates spatial and temporal LacZ expression in transgenic mouse embryos
    L N Wei
    Department of Microbiology and Immunology, Chang Gung Medical College, Tao Yuan, Taiwan, Republic of China
    Development 112:847-54. 1991
    ..Thus, it is concluded that the 3 kb sequence, but not the 583 bp sequence, of the mouse CRABP gene contains information for its temporally and spatially specific expression in mouse embryos...
  55. ncbi Localization of specific retinoid-binding sites and expression of cellular retinoic-acid-binding protein (CRABP) in the early mouse embryo
    L Dencker
    Department of Toxicology, University of Uppsala, Sweden
    Development 110:343-52. 1990
    ..We propose that the teratogenic effects of exogenous retinoids are due to an interference with mechanisms by which endogenous retinoic acid regulates differentiation and pattern formation in these tissues...
  56. ncbi Crystal structure of cellular retinoic acid binding protein I shows increased access to the binding cavity due to formation of an intermolecular beta-sheet
    J R Thompson
    Department of Biochemistry, School of Medicine, University of Minnesota, Minneapolis 55455, USA
    J Mol Biol 252:433-46. 1995
    A recombinant form of murine apo-cellular retinoic acid binding protein I (apo-CRABPI) has been purified and crystallized at pH 5.0, and the crystal structure has been refined to an R-factor of 19.6% at a resolution of 2.7 A...
  57. ncbi Postaxial polydactyly in forelimbs of CRABP-II mutant mice
    D Fawcett
    Division of Endocrinology, Hospital for Sick Children, Toronto, Canada
    Development 121:671-9. 1995
    ..This developmental abnormality implies a role for CRABP-II in normal patterning of the limb...
  58. ncbi Changes of the expression and distribution of retinoic acid receptors during neurogenesis in mouse embryos
    T Yamagata
    Department of Pediatrics, Jichi Medical School, Tochigi, Japan
    Brain Res Dev Brain Res 77:163-76. 1994
    ..The distribution of RAR-alpha- or -beta-positive cells were consistent with the neurogenesis during development in the spinal cord and brain...
  59. ncbi Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
    P J Swiatek
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 7:2071-84. 1993
    ..These data demonstrate that Krox20 plays an essential role during development of the hindbrain and associated cranial sensory ganglia in mice...
  60. ncbi Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development
    E Ruberte
    Laboratoire de Genetique Moleculaire des Eucaryotes, CNRS, INSERM Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Development 118:267-82. 1993
    ..The cytoplasmic binding proteins, cellular retinoic acid binding proteins type I and II (CRABP I and CRABP II) and cellular retinol binding protein type I (CRBP I), were widely distributed in developing neural ..
  61. ncbi Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain
    T Seitanidou
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Mech Dev 65:31-42. 1997
    ....
  62. ncbi Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
    K L Goh
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 124:4309-19. 1997
    ....
  63. ncbi Regulation of the mouse cellular retinoic acid-binding protein-I gene by thyroid hormone and retinoids in transgenic mouse embryos and P19 cells
    L N Wei
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Endocrinol 155:35-46. 1997
    ..A role of thyroid hormones in CRABP-I gene expression and vitamin A metabolism in animals is discussed...
  64. ncbi Regulation of the CRABP-I gene during mouse embryogenesis
    D A Kleinjan
    Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands
    Mech Dev 67:157-69. 1997
    ..One of these regulatory elements has the hallmarks of an RA response element, suggesting that CRABP-I expression in neural tissue can be directly modulated by RA via the RARs/RXRs...
  65. ncbi Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch
    A Gavalas
    Institut de Génétique et de Biologie Moléculaire and Cellulaire, CNRS INSERM ULP, College de France, BP 163 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 125:1123-36. 1998
    ..Taken together, our results unveil an extensive functional synergy between Hoxa1 and Hoxb1 that was not anticipated from the phenotypes of the simple null mutants...
  66. ncbi Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization
    L Yan
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, MN 55905, USA
    DNA Cell Biol 17:659-67. 1998
    ..Cloning and structural characterization of the mouse Nnmt gene will make it possible to study molecular genetic mechanisms involved in the expression of this important methyltransferase...
  67. ncbi Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1
    G B Mulder
    University Laboratory Animal Resources, University of California at Irvine 92697 1310, USA
    Teratology 58:263-75. 1998
    ..Further, the observed defects in thymus development may be mediated by RA-induced alterations in the expression of Hoxa3...
  68. ncbi Ebf1 controls early cell differentiation in the embryonic striatum
    S Garel
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 126:5285-94. 1999
    ....
  69. ncbi Retinoic acid synthesis and hindbrain patterning in the mouse embryo
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, CU de Strasbourg
    Development 127:75-85. 2000
    ..We conclude that RA produced by the embryo is required to generate posterior cell fates in the developing mouse hindbrain, its absence leading to an abnormal r3 (and, to a lesser extent, r4) identity of the caudal hindbrain cells...
  70. ncbi Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid
    S M Ulven
    Institute for Nutrition Research, University of Oslo, Blindern, Oslo, 0316, Norway
    Dev Biol 220:379-91. 2000
    ..Therefore, our results suggest that RALDH2 is a key regulator in initiating retinoic acid synthesis sometime between the mid-primitive streak stage and the late allantoic bud stage in mouse embryos...
  71. ncbi Spatio-temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP- and CRBPI-null mutant mice
    R Romand
    Laboratoire de Neurobiologie, Universite Blaise Pascal, 63177 Aubiere Cedex, France
    Eur J Neurosci 12:2793-804. 2000
    ..Expression of the cellular retinoic acid binding protein I (CRABPI) is restricted during development in Kölliker's organ whilst cellular retinol binding protein II (CRBPII) is only ..
  72. ncbi Effects of excess vitamin A on development of cranial neural crest-derived structures: a neonatal and embryologic study
    G B Mulder
    University Laboratory Animal Resources, University of California, Irvine, California 92697, USA
    Teratology 62:214-26. 2000
    ..Our prior studies with retinoic acid have established that gestational day (gd) 9 is a sensitive embryonic age in the mouse for inducing craniofacial and thymic defects...
  73. ncbi Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol
    S Vogel
    Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons of Columbia University, New York, New York, 10032, USA
    J Biol Chem 276:1353-60. 2001
    ..The distinct tissue expression pattern and binding specificity suggest that we have identified a novel FABP family member, cellular retinol-binding protein, type III...
  74. ncbi Expression of CRABP I mRNA in fastigial cells of the developing cerebellum
    Rosalba Parenti
    Department of Physiological Science, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
    Eur J Neurosci 15:211-5. 2002
    The expression of the cellular retinoic acid binding protein type I (CRABP I) was examined in the early phase of cerebellar development in the mouse. The CRABP I was expressed from embryonic day (E) 10.5 to E15.5 in the cerebellar plate...
  75. ncbi Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 129:3563-74. 2002
    ..We suggest that RA signaling cooperates with a posteriorly restricted factor such as dHand, to generate a functional zone of polarizing activity (ZPA)...
  76. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
  77. pmc Analysis of gene expression in the developing mouse retina
    Elva Diaz
    Department of Molecular and Cell Biology, Functional Genomics Laboratory, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 100:5491-6. 2003
    ..A common theme for the identified genes is the differential expression in the dorsal-ventral axis. By analyzing gene expression patterns, we provide insight into the molecular organization of the developing retina...
  78. ncbi The meninges is a source of retinoic acid for the late-developing hindbrain
    Jinghua Zhang
    E Kennedy Shriver Center, University of Massachusetts Medical School, University of Massachusetts, Waltham, Massachusetts 02452, USA
    J Neurosci 23:7610-20. 2003
    ....
  79. ncbi Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene
    Li na Wei
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson, Minneapolis, MN 55455, USA
    Mol Cell Endocrinol 218:39-48. 2004
    ..protein 140 (RIP140) suppressed thyroid hormone (T3) induction of cellular retinoic acid binding I protein (CRABPI) gene in P19 embryonal carcinoma cells...
  80. ncbi Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice
    Tatsuo Furuyama
    Department of Molecular Genetics and Geriatric Research, National Institute for Longevity Sciences, Kumamoto University, Kumamoto 860 0811, Japan
    J Biol Chem 279:34741-9. 2004
    ..These results suggest that Foxo1 is essential to the ability of endothelial cells to respond properly to a high dose of VEGF, thereby playing a critical role in normal vascular development...
  81. pmc Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo
    Sophie Remacle
    Unit of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Mol Cell Biol 24:8567-75. 2004
    ....
  82. ncbi The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 13:2829-40. 2004
    ..While no abnormalities in branchiomeric myogenesis were detected in Tbx1(+/-) mice, reduced TBX1 levels may contribute to pharyngeal hypotonia in del22q11.2 patients...
  83. ncbi Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation
    Takako Makita
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 280:59-72. 2005
    ..5 onward is enhancer-independent, and is driven instead by basal promoter elements that provide a sufficient level of expression to support further erythropoietic differentiation...
  84. ncbi Sonic hedgehog is required for cardiac outflow tract and neural crest cell development
    I Washington Smoak
    North Carolina State University, Raleigh, 27695, USA
    Dev Biol 283:357-72. 2005
    ..Our data suggest that SHH signaling does not act directly on NCCs as a survival factor, but rather acts to restrict the domains that NCCs can populate during early stages (e8.5-10.5) of cardiovascular and craniofacial development...
  85. pmc Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning
    Andrei Molotkov
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 133:1901-10. 2006
    ..At all stages, RA target tissues are distinct from locations of RA synthesis, indicating that RALDHs function cell-nonautonomously to generate paracrine RA signals that guide morphogenetic movements in neighboring cells...
  86. ncbi Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice
    Anita Marguerie
    Cancer Research UK, London Research Institute, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cardiovasc Res 71:50-60. 2006
    ..In order to define the role of fibroblast growth factor (FGF) signaling in this process we investigated whether Fgf10 or the major Fgf10 receptor Fgfr2-IIIb are required for normal heart development...
  87. pmc Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 103:10300-4. 2006
    ....
  88. ncbi Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
    Pontus C Holm
    Institute for Stem Cell Research, National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 34:99-119. 2007
    ..Most intriguingly, this analysis revealed time- and region-specific differences in Pax6-mediated transcription, explaining the specific function of Pax6 at early and later stages of neurogenesis...
  89. ncbi Cardiovascular abnormalities in Folr1 knockout mice and folate rescue
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 79:257-68. 2007
    ..Folate-binding proteins or receptors serve to bind folic acid and 5-methyltetrahydrofolate, representing one of the two major mechanisms of cellular folate uptake...
  90. ncbi Dynamic changes in gene expression profiles of 22q11 and related orthologous genes during mouse development
    Francesca Amati
    Department of Biopathology and Diagnostic Imaging, Tor Vergata University, Rome, Italy
    Gene 391:91-102. 2007
    ..5, 8.5 and 14.5 dpc. These data are likely to be helpful in studying developmental anomalies detected in del22q11 patients...
  91. ncbi Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development
    Matthew M Goddeeris
    Departments of Cell Biology and Pediatrics, Neonatal Perinatal Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:1593-604. 2007
    ..Disruption of any of these steps can result in a single OFT phenotype...
  92. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  93. doi Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling
    Charlotte A Collins
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Dev Biol 324:55-67. 2008
    ..We show that cellular RA-binding proteins CRABP1 and CRABP2 and the fatty acid-binding protein FABP5 are dynamically expressed during skin development and in adult ..
  94. pmc Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo
    Subreena Simrick
    Department of Craniofacial Development, King s College London, Floor 27, Guy s Tower, London, SE1 9RT, UK
    Dev Biol 358:147-55. 2011
    ....
  95. ncbi Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development
    D E Smith
    Department of Cell and Developmental Biology, Roche Research Center, Nutley, NJ 07110
    Development 116:1033-9. 1992
    ..These results suggest multiple roles for the Sna gene in gastrulation and organogenesis during murine development...
  96. ncbi Localization of the cellular retinoic acid binding protein (CRABP) gene relative to the acute promyelocytic leukemia-associated breakpoint on human chromosome 15
    A Geurts van Kessel
    Department of Human Genetics, University of Nijmegen, The Netherlands
    Hum Genet 87:201-4. 1991
    ..Thus, the observed lack of CRABP expression in these leukemic cells may not be caused by disruption of its gene. CRABP maps to the region 15q22-qter...
  97. ncbi Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis
    P Dolle
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184, Strasbourg, France
    Development 110:1133-51. 1990
    ....
  98. ncbi Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse
    P Dolle
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Nature 342:702-5. 1989
    ..CRABP transcripts, however, are excluded from regions expressing mRAR gamma and mRAR beta. These results indicate that all three RARs and CRABP have specific functions during morphogenesis and differentiation of the mouse limb...
  99. ncbi The role of Hoxa-3 in mouse thymus and thyroid development
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Development 121:1989-2003. 1995
    ..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3...
  100. ncbi Analysis of the factors involved in the retinoic acid-induced differentiation of a retinoid-hypersensitive embryonal carcinoma cell mutant
    J M Dietrich
    Department of Biological Sciences, SUNY Albany 12222
    Exp Cell Res 210:201-8. 1994
    ..Our results indicate that CRABP I, RAR beta, and RAR gamma mRNAs are expressed differentially between parent and RA-hypersensitive mutant cells...
  101. ncbi The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture
    M W Kelley
    Department of Otolaryngology HNS, University of Virginia School of Medicine, Charlottesville 22908
    Development 119:1041-53. 1993
    ....