Cplx3

Summary

Gene Symbol: Cplx3
Description: complexin 3
Alias: BC016632, CpxIII, ERGIC-53L, ERGL, Lamn1l, Lman1l, complexin-3, CPX III, complexin III, lectin, mannose-binding, 1 like
Species: mouse

Top Publications

  1. doi Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4
    Kerstin Reim
    Department of Molecular Neurobiology and Center for the Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Sci 122:1352-61. 2009
  2. pmc Structurally and functionally unique complexins at retinal ribbon synapses
    Kerstin Reim
    Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Biol 169:669-80. 2005
  3. doi Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse
    Nicola Strenzke
    InnerEarLab, Department of Otolaryngology, Göttingen University Medical School, D 37099 Göttingen, Germany
    J Neurosci 29:7991-8004. 2009
  4. doi The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones
    Cordelia Imig
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 84:416-31. 2014
  5. doi Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction
    Azusa Kurokawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Neurochem 133:806-14. 2015
  6. pmc Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses
    Lena S Mortensen
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Cell Rep 15:2239-50. 2016
  7. doi Functional Roles of Complexin3 and Complexin4 at Mouse Photoreceptor Ribbon Synapses
    Norbert Babai
    Department of Biology, Animal Physiology, Friedrich Alexander University Erlangen Nurnberg, 91058 Erlangen, Germany, and
    J Neurosci 36:6651-67. 2016
  8. pmc TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons
    Xavier Caubit
    Aix Marseille Universite, CNRS, IBDM, Marseille, France
    Nat Genet 48:1359-1369. 2016
  9. doi Molecular diversity of early-born subplate neurons
    Anna Hoerder-Suabedissen
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Cereb Cortex 23:1473-83. 2013
  10. doi The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina
    Immanuel Landgraf
    Department of Biology and Environmental Sciences, Neurobiology, University of Oldenburg, 26111 Oldenburg, Germany
    Eur J Neurosci 36:2470-81. 2012

Scientific Experts

  • Mingshan Xue
  • Kerstin Reim
  • Nils Brose
  • Anna Hoerder-Suabedissen
  • Cordelia Imig
  • Johann Helmut Brandstätter
  • Norbert Babai
  • Xavier Caubit
  • Lena S Mortensen
  • Benjamin H Cooper
  • Azusa Kurokawa
  • Hanna Regus-Leidig
  • Immanuel Landgraf
  • Zoltan Molnar
  • Josef Ammermüller
  • George Zanazzi
  • Christian Rosenmund
  • Nicola Strenzke
  • Emeric Dubois
  • Adrian S Woolf
  • Eva Rudd
  • Joshua H Singer
  • Bernard Jacq
  • Bénédicte Duban
  • Jasmin Mertins
  • Fatimetou Abderrehamane
  • Jonathan B Demb
  • Catherine Vincent-Delorme
  • Detlef Bockenhauer
  • Andreas Feigenspan
  • Anna Sendelbeck
  • Jean François Lemaître
  • Nenad Sestan
  • Agne Lieden
  • Pascal Salin
  • Jean Marie Cuisset
  • Alistair N Garratt
  • Lydia Kerkerian-Le Goff
  • Jiang Bin Ke
  • Joris Andrieux
  • Marie Pierre Lemaitre
  • Laurence Had-Aissouni
  • Mehdi Metwaly
  • Laurent Fasano
  • Michaela Fuchs
  • Jeong Seop Rhee
  • Paolo Gubellini
  • Kenneth Y Kwan
  • Dany Severac
  • Silvia J H Park
  • Ying Zhu
  • Lei Zhang
  • Ahmed Fatmi
  • Siegrid Lowel
  • Michele Carlier
  • Marwan Shinawi
  • Pierre L Roubertoux
  • Keiko Abe
  • Makoto Ohmoto
  • Masataka Narukawa
  • Joto Yoshimoto
  • Takumi Misaka
  • Stefanie Krinner
  • Sang Won Min
  • JeongSeop Rhee
  • Thomas C Sudhof
  • Marife Arancillo
  • Karin Dedek
  • Johanna Mühlhans
  • Johann H Brandstätter
  • Gary Matthews
  • Wei Zhi Wang
  • Ahmed El-Kordi
  • Sonja Rakic
  • Andre M Goffinet
  • Kay E Davies
  • Fred Wolf
  • Konstantin Radyushkin
  • Matthew A Xu-Friedman
  • Margareta Nicolic
  • Soham Chanda
  • Anna V Bulankina
  • Tobias Moser
  • Ole Paulsen
  • Cornelia Kopp-Scheinpflug
  • John Parnavelas
  • Andreas Neef
  • Darina Khimich
  • Hannelore Ehrenreich
  • Sheena Lee

Detail Information

Publications14

  1. doi Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4
    Kerstin Reim
    Department of Molecular Neurobiology and Center for the Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Sci 122:1352-61. 2009
    ..Two of the vertebrate complexins, Cplx3 and Cplx4, are specifically localized to retinal ribbon synapses...
  2. pmc Structurally and functionally unique complexins at retinal ribbon synapses
    Kerstin Reim
    Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Biol 169:669-80. 2005
    ..The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons...
  3. doi Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse
    Nicola Strenzke
    InnerEarLab, Department of Otolaryngology, Göttingen University Medical School, D 37099 Göttingen, Germany
    J Neurosci 29:7991-8004. 2009
    ..Although sound encoding in the cochlea proceeds in the absence of complexins, CPX I is required for faithful processing of sound onset and offset in the cochlear nucleus...
  4. doi The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones
    Cordelia Imig
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 84:416-31. 2014
    ....
  5. doi Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction
    Azusa Kurokawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Neurochem 133:806-14. 2015
    ..Furthermore, taste responses to some sour stimuli in CPLX2- knockout mice were significantly lower than those in wild-type mice. These suggested that CPLX2 participated in synaptic taste transduction. ..
  6. pmc Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses
    Lena S Mortensen
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Cell Rep 15:2239-50. 2016
    ..To understand the contributions of Cplx to signaling in a well-characterized neural circuit, we investigated how Cplx3, a retina-specific paralog, shapes transmission at rod bipolar (RB)→AII amacrine cell synapses in the mouse ..
  7. doi Functional Roles of Complexin3 and Complexin4 at Mouse Photoreceptor Ribbon Synapses
    Norbert Babai
    Department of Biology, Animal Physiology, Friedrich Alexander University Erlangen Nurnberg, 91058 Erlangen, Germany, and
    J Neurosci 36:6651-67. 2016
    ..We have shown previously that photoreceptor ribbon synapses in mouse retina are equipped with Cplx3 and Cplx4 and that lack of both Cplxs perturbs photoreceptor ribbon synaptic function; however, Cplx3/4 function ..
  8. pmc TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons
    Xavier Caubit
    Aix Marseille Universite, CNRS, IBDM, Marseille, France
    Nat Genet 48:1359-1369. 2016
    ..These findings highlight essential roles for Tshz3 in CPN development and function, whose alterations can account for ASD in the newly defined TSHZ3 deletion syndrome...
  9. doi Molecular diversity of early-born subplate neurons
    Anna Hoerder-Suabedissen
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Cereb Cortex 23:1473-83. 2013
    ..The postnatal subplate layer in mouse contains neurons with expression of the presynaptic protein complexin 3 (Cplx3), connective tissue growth factor (CTGF), the orphan nuclear receptor Nr4a2 (Nurr1), and the G-protein-..
  10. doi The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina
    Immanuel Landgraf
    Department of Biology and Environmental Sciences, Neurobiology, University of Oldenburg, 26111 Oldenburg, Germany
    Eur J Neurosci 36:2470-81. 2012
    ..Most importantly, Cplx 3 is localized in the lobular appendages of AII amacrine cells, the sites of signal transmission from the primary rod pathway into the OFF pathway in the inner plexiform layer...
  11. pmc Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system
    Mingshan Xue
    Departments of Neuroscience and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:7875-80. 2008
    ..Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery...
  12. doi Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex
    Anna Hoerder-Suabedissen
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Cereb Cortex 19:1738-50. 2009
    ..In situ hybridization or immunohistochemistry confirmed subplate-selective expression of complexin 3, connective tissue growth factor, nuclear receptor-related 1/Nr4a2, and monooxygenase Dbh-like 1 while ..
  13. pmc Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:367-80. 2009
    ....
  14. pmc Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development
    George Zanazzi
    Graduate Program in Neuroscience, State University of New York, Stony Brook, NY 11794, USA
    Neural Dev 5:24. 2010
    ....