Cplx2

Summary

Gene Symbol: Cplx2
Description: complexin 2
Alias: 921-L, AI413745, AW492120, complexin-2, CPX II, complexin II, synaphin-1
Species: mouse

Top Publications

  1. pmc Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems
    Ming Yi Lin
    Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2520, USA
    J Physiol 591:2463-73. 2013
  2. pmc Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:367-80. 2009
  3. doi Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse
    Nicola Strenzke
    InnerEarLab, Department of Otolaryngology, Göttingen University Medical School, D 37099 Göttingen, Germany
    J Neurosci 29:7991-8004. 2009
  4. pmc Complexin controls the force transfer from SNARE complexes to membranes in fusion
    Anton Maximov
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 323:516-21. 2009
  5. pmc Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming
    Haijiang Cai
    Department of Physiology and Biophysics, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 105:19538-43. 2008
  6. pmc Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system
    Mingshan Xue
    Departments of Neuroscience and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:7875-80. 2008
  7. ncbi Complexins regulate a late step in Ca2+-dependent neurotransmitter release
    K Reim
    Max Planck Institut fur experimentelle Medizin, Abteilung Neurogenetik, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075 Gottingen, Bundesrepublik, Deutschland
    Cell 104:71-81. 2001
  8. doi Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons
    Gülcin Vardar
    Department of Neurophysiology and NeuroCure Cluster of Excellence, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Neurosci 36:7911-24. 2016
  9. doi Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction
    Azusa Kurokawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Neurochem 133:806-14. 2015
  10. doi The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones
    Cordelia Imig
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 84:416-31. 2014

Scientific Experts

  • Huan Yu
  • Wanjin Hong
  • Dervila Glynn
  • A Jennifer Morton
  • Michael B Butterworth
  • Mingshan Xue
  • Kerstin Reim
  • Nils Brose
  • Thomas C Sudhof
  • Xiaofei Yang
  • Christian Rosenmund
  • Haijiang Cai
  • Whitney Freeman
  • Gülcin Vardar
  • Azusa Kurokawa
  • Marife Arancillo
  • Cordelia Imig
  • Madhurima Dhara
  • Ming Yi Lin
  • Ziying Wang
  • Mohiuddin Ahmad
  • Thomas J Ha
  • K Reim
  • Robert H Chow
  • K Radyushkin
  • Lucian Medrihan
  • Yue Yang
  • Anton Maximov
  • Nicola Strenzke
  • S Takahashi
  • N Brose
  • Yoshitake Yamauchi
  • Natalja M Raevskaya
  • Helen E Gibson
  • G Z Huang
  • Yuan Ju Wu
  • Shuwen Chang
  • Thorsten Trimbuch
  • Masataka Narukawa
  • Takumi Misaka
  • Joto Yoshimoto
  • Keiko Abe
  • Makoto Ohmoto
  • Stefanie Krinner
  • Chad Grabner
  • H Kaba
  • Ralf Mohrmann
  • Paanteha K Moghadam
  • Claudia Schirra
  • Sang Won Min
  • Soumyajit Dutta
  • Anneka Bost
  • Jens Rettig
  • Antonio Yarzagaray
  • Benjamin H Cooper
  • Yvonne Schwarz
  • JeongSeop Rhee
  • Dieter Bruns
  • Peng Cao
  • Chien Ping Ko
  • Joyce G Rohan
  • Kang Liu
  • Jiang Liu
  • Hongyu Zhang
  • Xiumei Zhang
  • Yeteng He
  • Weichen Shi
  • Tianfeng Zhu
  • Xinbing Wei
  • Fan Yi
  • Fengli Li
  • Yan Zhang
  • Fan Yang
  • Huiyan Xu
  • Daniel Goldowitz
  • Douglas J Swanson
  • Debanjan Goswami
  • Joanna Yeung
  • Roumyana Kirova
  • Yiai Tong
  • Elissa J Chesler
  • Robert C Malenka
  • Kunho Choi
  • Jai S Polepalli
  • Yea Jin Kaeser-Woo
  • H T McMahon
  • J Frahm
  • A Ronnenberg
  • S Castaneda
  • H Bickeboller

Detail Information

Publications35

  1. pmc Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems
    Ming Yi Lin
    Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2520, USA
    J Physiol 591:2463-73. 2013
    ....
  2. pmc Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:367-80. 2009
    ....
  3. doi Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse
    Nicola Strenzke
    InnerEarLab, Department of Otolaryngology, Göttingen University Medical School, D 37099 Göttingen, Germany
    J Neurosci 29:7991-8004. 2009
    ..Although sound encoding in the cochlea proceeds in the absence of complexins, CPX I is required for faithful processing of sound onset and offset in the cochlear nucleus...
  4. pmc Complexin controls the force transfer from SNARE complexes to membranes in fusion
    Anton Maximov
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 323:516-21. 2009
    ..Thus, complexin probably activates and clamps the force transfer from assembled trans-SNARE complexes onto fusing membranes...
  5. pmc Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming
    Haijiang Cai
    Department of Physiology and Biophysics, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 105:19538-43. 2008
    ..We show that adrenal chromaffin cells from CPX II knockout mice exhibit markedly diminished releasable vesicle pools (comprising the readily and slowly releasable ..
  6. pmc Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system
    Mingshan Xue
    Departments of Neuroscience and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:7875-80. 2008
    ..Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery...
  7. ncbi Complexins regulate a late step in Ca2+-dependent neurotransmitter release
    K Reim
    Max Planck Institut fur experimentelle Medizin, Abteilung Neurogenetik, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075 Gottingen, Bundesrepublik, Deutschland
    Cell 104:71-81. 2001
    ....
  8. doi Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons
    Gülcin Vardar
    Department of Neurophysiology and NeuroCure Cluster of Excellence, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Neurosci 36:7911-24. 2016
    ....
  9. doi Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction
    Azusa Kurokawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Neurochem 133:806-14. 2015
    ..Among four Cplx isoforms, strong expression of Cplx2 mRNA was detected in type III taste cells...
  10. doi The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones
    Cordelia Imig
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 84:416-31. 2014
    ....
  11. pmc Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics
    Madhurima Dhara
    Institute for Physiology, University of Saarland, 66424 Homburg Saar, Germany
    J Cell Biol 204:1123-40. 2014
    ..Thus, our results illustrate how key features of CpxII, SytI, and their interplay transform the constitutively active SNARE-mediated fusion mechanism into a highly synchronized, Ca(2+)-triggered release apparatus. ..
  12. pmc Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes
    Xiaofei Yang
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305
    Proc Natl Acad Sci U S A 110:20777-82. 2013
    ....
  13. doi NOX2 deficiency ameliorates cerebral injury through reduction of complexin II-mediated glutamate excitotoxicity in experimental stroke
    Ziying Wang
    Department of Pharmacology, School of Medicine, Shandong University, Jinan, Shandong 250012, China
    Free Radic Biol Med 65:942-51. 2013
    ..In this study, we first identified the upregulation of complexin II in the ischemic brain and evaluated its potential role in ischemic stroke showing that gene silencing of ..
  14. pmc Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum
    Thomas J Ha
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, Canada
    Eur J Neurosci 36:2888-98. 2012
    ..The candidate genes identified in this way represent direct or indirect Pax6-downstream genes involved in cerebellar development...
  15. pmc Postsynaptic complexin controls AMPA receptor exocytosis during LTP
    Mohiuddin Ahmad
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford CA 94305, USA
    Neuron 73:260-7. 2012
    ..These results suggest a complexin-dependent molecular mechanism for regulating AMPAR delivery to synapses, a mechanism that is surprisingly similar to presynaptic exocytosis but controlled by regulators other than synaptotagmin-1...
  16. ncbi [Effects of neonatal isolation stress on hyperlocomotion of complexin II knockout mouse]
    Huan Yu
    Department of Physiology and Pathophysiology, Basic Medical School of Jiujiang University, Jiujiang 332000, China
    Sheng Li Xue Bao 63:300-4. 2011
    The aim of this study was to investigate the influence of neonatal isolation stress on hyperlocomotion in complexin II knockout mouse (Cplx2(-/-))...
  17. ncbi Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HD
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Brain Res Bull 72:108-20. 2007
    ..One protein that may contribute to neurological dysfunction in HD is complexin II. Complexins are presynaptic proteins that are believed to modulate neurotransmitter release...
  18. ncbi Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses
    S Takahashi
    Department of Immunology, Kochi Medical School, Japan
    FEBS Lett 368:455-60. 1995
    ..Immuno-electron microscopic study revealed that both 921 proteins are localized at the presynaptic terminal, indicating that the 921 proteins are differentially expressed at the dendritic and somatic presynapses...
  19. ncbi Reduced hippocampal LTP in mice lacking a presynaptic protein: complexin II
    S Takahashi
    Department of Physiology, Nankoku, Kochi 783 8505, Japan
    Eur J Neurosci 11:2359-66. 1999
    ..To examine this possibility and to understand the physiological function of complexins, we generated complexin II knockout mice. The complexin-II-deficient mice (-/-) were viable and fertile, and appeared normal...
  20. ncbi Involvement of complexin II in synaptic plasticity in the CA1 region of the hippocampus: the use of complexin II-lacking mice
    G Z Huang
    Department of Neuropsychiatry, Kochi Medical School, Nankoku, Japan
    Jpn J Pharmacol 84:179-87. 2000
    An electrophysiological study was performed with mice lacking complexin II, a presynaptic protein...
  21. ncbi Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease
    A J Morton
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    J Neurochem 76:166-72. 2001
    ..Here we describe the specific and progressive loss of complexin II from the brains of mice carrying the HD mutation (R6/2 line), and the later appearance of this protein in a ..
  22. ncbi Complexin II is essential for normal neurological function in mice
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, UK
    Hum Mol Genet 12:2431-48. 2003
    ..Given that decreased expression of CPLXII is seen in HD and schizophrenic patients, a role for CPLXII depletion should be considered in other diseases where motor, cognitive and psychiatric symptoms co-exist...
  23. ncbi Differential messenger RNA expression of complexins in mouse brain
    Whitney Freeman
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Brain Res Bull 63:33-44. 2004
    ....
  24. ncbi Regional and progressive changes in brain expression of complexin II in a mouse transgenic for the Huntington's disease mutation
    Whitney Freeman
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Brain Res Bull 63:45-55. 2004
    ..We have shown previously that there is a decrease in protein levels of the SNARE-associated protein, complexin II (CPLXII) in Huntington's disease brain and in the R6/2 mouse model of Huntington's disease...
  25. doi Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Hum Mol Genet 19:3402-12. 2010
    b>Complexin 2 is a protein modulator of neurotransmitter release that is downregulated in humans suffering from depression, animal models of depression and neurological disorders such as Huntington's disease in which depression is a major ..
  26. doi Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia
    K Radyushkin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Genes Brain Behav 9:592-602. 2010
    ..As dysfunction in synaptic transmission plays a key role in schizophrenia, and complexin2 (CPLX2) gene expression is reduced in hippocampus of schizophrenic patients, we developed a mouse model with Cplx2 null ..
  27. ncbi SNAREs and traffic
    Wanjin Hong
    Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore
    Biochim Biophys Acta 1744:120-44. 2005
    ..In the post-genomic era, a fairly complete list of "all" SNAREs in several organisms (including human) can now be made. This review aims to summarize the key properties and the mechanism of action of SNAREs in mammalian cells...
  28. pmc A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation
    Yue Yang
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 326:575-8. 2009
    ..The NeuroD2 target gene encoding Complexin II, which acts locally at presynaptic sites, mediated the ability of NeuroD2 to suppress presynaptic ..
  29. pmc Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses
    Lucian Medrihan
    Center for Physiology, Georg August University and DFG Research Center of Molecular Physiology of the Brain, D 37073 Gottingen, Germany
    J Physiol 587:5095-106. 2009
    ....
  30. pmc Structurally and functionally unique complexins at retinal ribbon synapses
    Kerstin Reim
    Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Biol 169:669-80. 2005
    ..The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons...
  31. ncbi PKA-dependent ENaC trafficking requires the SNARE-binding protein complexin
    M B Butterworth
    Dept of Cell Biology and Physiology, University of Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 289:F969-77. 2005
    ..b>Complexin II mRNA coexpressed with alpha-, beta-, and gamma-ENaC subunits in Xenopus laevis oocytes reduced sodium currents ..
  32. ncbi Vulnerability of synaptic plasticity in the complexin II knockout mouse to maternal deprivation stress
    Yoshitake Yamauchi
    Department of Neuropsychiatry, Kochi Medical School, Kohasu, Nankoku City, Kochi 783 8505, Japan
    Brain Res 1056:59-67. 2005
    ..Postmortem studies in schizophrenic patients have shown that expression of complexin II, which is involved in neurotransmitter release at central nervous system synapses, is decreased in the brain...
  33. ncbi Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity
    Natalja M Raevskaya
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia
    Gene 359:127-37. 2005
    We report here on the in vitro and in silico characterization of the organization of the human complexin 2 (CPLX2) gene. This encodes for a protein of 134 amino acid residues, contains five exons, is localized on human chromosome 5q35...
  34. ncbi A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse
    Helen E Gibson
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Eur J Neurosci 22:1701-12. 2005
    b>Complexin II is reduced in Huntington's disease (HD) patients and in the R6/2 mouse model of HD. Mice lacking complexin II (Cplx2-/- mice) show selective cognitive deficits that reflect those seen in R6/2 mice...
  35. ncbi Complexins: cytosolic proteins that regulate SNAP receptor function
    H T McMahon
    Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas 75235, USA
    Cell 83:111-9. 1995
    ..homologous hydrophilic proteins that are tightly conserved, with 100% identity among mouse, rat, and human complexin II. They are enriched in neurons where they colocalize with syntaxin and SNAP-25; in addition, complexin II is ..