Col8a1

Summary

Gene Symbol: Col8a1
Description: collagen, type VIII, alpha 1
Alias: Col8a-1, collagen alpha-1(VIII) chain, procollagen type VIII alpha 1
Species: mouse

Top Publications

  1. ncbi Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye
    Ulrike Hopfer
    Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    FASEB J 19:1232-44. 2005
  2. ncbi alpha 1(VIII)-collagen gene transcripts encode a short-chain collagen polypeptide and are expressed by various epithelial, endothelial and mesenchymal cells in newborn mouse tissues
    Y Muragaki
    Department of Pathology, Wakayama Medical College, Japan
    Eur J Biochem 207:895-902. 1992
  3. ncbi Astrocytes express type VIII collagen during the repair process of brain cold injury
    Shuichi Hirano
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 317:437-43. 2004
  4. ncbi Migration and growth are attenuated in vascular smooth muscle cells with type VIII collagen-null alleles
    Eser Adiguzel
    Department of Laboratory Medicine, University of Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 26:56-61. 2006
  5. doi Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice
    Biljana Skrbic
    Department of Cardiothoracic Surgery, Oslo University Hospital Ulleval, Kirkeveien 166, Oslo 0407, Norway Faculty of Medicine, University of Oslo, Oslo, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    Cardiovasc Res 106:32-42. 2015
  6. ncbi The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1
    Y Muragaki
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115 6092
    J Biol Chem 266:7721-7. 1991
  7. doi Type VIII collagen signals via β1 integrin and RhoA to regulate MMP-2 expression and smooth muscle cell migration
    Eser Adiguzel
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario M5S 1A8, Canada
    Matrix Biol 32:332-41. 2013
  8. pmc Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis
    Joshua Lopes
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 182:2241-53. 2013
  9. doi Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy
    Ivonne Loeffler
    Department of Internal Medicine III, University Hospital, University of Jena, Erlanger Allee 101, Jena, Germany
    Am J Physiol Renal Physiol 303:F733-45. 2012
  10. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007

Scientific Experts

  • Kristopher R Schwab
  • Eser Adiguzel
  • Ivonne Loeffler
  • Ulrike Hopfer
  • Gunter Wolf
  • Biljana Skrbic
  • Joshua Lopes
  • Michelle P Bendeck
  • Olga A Cherepanova
  • Yongfu Zhao
  • Naomi Fukai
  • Helmut Hopfer
  • Bjorn R Olsen
  • Diana L Walker
  • Shuichi Hirano
  • Marc Kvansakul
  • Geir Christensen
  • Cathrine R Carlson
  • Kate M Herum
  • Ivar Sjaastad
  • Johannes L Bjørnstad
  • Mari E Strand
  • Theis Tønnessen
  • Kristin V T Engebretsen
  • Per K Lunde
  • Henriette S Marstein
  • Ida G Lunde
  • Shu Lin Liu
  • Richard K Assoian
  • Scott Heximer
  • Guangpei Hou
  • Steven Gu
  • Marita Liebisch
  • Dirk Koczan
  • Yongji Liu
  • Qiong Gan
  • Henggui Xu
  • Catherine Meyer-Schwesinger
  • Gary K Owens
  • Nataliya A Pidkovka
  • Rolf A K Stahl
  • Li Jia
  • Olga F Sarmento
  • Bo Wang
  • Judith Berliner
  • Norbert Leitinger
  • Xiaoyan Mao
  • Tadashi Yoshida
  • Nancy Joyce
  • Scott J Vacha
  • Cecilia W Lo
  • En Li
  • Margaret L Kirby
  • Haruko Hasegawa
  • Paul F Davis
  • Shunji Hattori
  • Yoshifumi Ninomiya
  • E Helene Sage
  • Tomoko Yonezawa
  • Nicholas S Greenhill
  • Avner Yayon
  • Oren Bogin
  • Erhard Hohenester
  • Y Muragaki
  • B R Olsen
  • Y Ninomiya
  • C Shiota
  • M L Iruela-Arispe
  • A Ooshima
  • M Inoue
  • O Jacenko
  • M G Mattei
  • E H Sage
  • S Apte

Detail Information

Publications17

  1. ncbi Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye
    Ulrike Hopfer
    Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    FASEB J 19:1232-44. 2005
    ..the function of collagen VIII in mice by targeted inactivation of the genes encoding the two polypeptide subunits, Col8a1 and Col8a2...
  2. ncbi alpha 1(VIII)-collagen gene transcripts encode a short-chain collagen polypeptide and are expressed by various epithelial, endothelial and mesenchymal cells in newborn mouse tissues
    Y Muragaki
    Department of Pathology, Wakayama Medical College, Japan
    Eur J Biochem 207:895-902. 1992
    ....
  3. ncbi Astrocytes express type VIII collagen during the repair process of brain cold injury
    Shuichi Hirano
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 317:437-43. 2004
    ..These data indicate that type VIII collagen plays an important role in glial scar formation during the repair process by astrocytes...
  4. ncbi Migration and growth are attenuated in vascular smooth muscle cells with type VIII collagen-null alleles
    Eser Adiguzel
    Department of Laboratory Medicine, University of Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 26:56-61. 2006
    ..To address this, we have compared aortic SMCs from wild-type (WT) mice to SMCs from type VIII collagen-deficient (KO) mice when plated on type I collagen...
  5. doi Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice
    Biljana Skrbic
    Department of Cardiothoracic Surgery, Oslo University Hospital Ulleval, Kirkeveien 166, Oslo 0407, Norway Faculty of Medicine, University of Oslo, Oslo, Norway KG Jebsen Centre for Cardiac Research and Center for Heart Failure Research, University of Oslo, Oslo, Norway Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    Cardiovasc Res 106:32-42. 2015
    ..A reduction in colVIII might be involved in LV dilatation, and we here examined the role of reduced colVIII in pressure overload-induced remodelling using colVIII knock-out (col8KO) mice...
  6. ncbi The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1
    Y Muragaki
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115 6092
    J Biol Chem 266:7721-7. 1991
    ..By in situ hybridization we demonstrate that the alpha 2(VIII) gene is located in the p32.3-p34.3 region of the short arm of chromosome 1...
  7. doi Type VIII collagen signals via β1 integrin and RhoA to regulate MMP-2 expression and smooth muscle cell migration
    Eser Adiguzel
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario M5S 1A8, Canada
    Matrix Biol 32:332-41. 2013
    ..In conclusion, we have shown that type VIII collagen signals through beta-1 integrin receptors to suppress RhoA, allowing optimal configuration of the cytoskeleton, and the stimulation of MMP-2-dependent cell migration. ..
  8. pmc Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis
    Joshua Lopes
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 182:2241-53. 2013
    ..We discovered that apolipoprotein E (ApoE) is an endogenous repressor of the Col8a1 chain, and, therefore, in ApoE knockout mice, type VIII collagen was up-regulated...
  9. doi Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy
    Ivonne Loeffler
    Department of Internal Medicine III, University Hospital, University of Jena, Erlanger Allee 101, Jena, Germany
    Am J Physiol Renal Physiol 303:F733-45. 2012
    ....
  10. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  11. pmc Type VIII collagen modulates TGF-β1-induced proliferation of mesangial cells
    Ivonne Loeffler
    Department of Internal Medicine III, University of Jena, Erlanger Allee 101, D 07740 Jena, Germany
    J Am Soc Nephrol 22:649-63. 2011
    ..VIII collagen, a nonfibrillar protein that exists as a heterodimer composed of α1(VIII) and α2(VIII), encoded by Col8a1 and Col8a2, respectively...
  12. pmc Lack of type VIII collagen in mice ameliorates diabetic nephropathy
    Ulrike Hopfer
    Department of Medicine, University of Hamburg, Hamburg, Germany
    Diabetes 58:1672-81. 2009
    ....
  13. pmc Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration
    Olga A Cherepanova
    Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA
    Circ Res 104:609-18. 2009
    ..POVPC increased expression of type VIII collagen alpha1 chain (Col8a1) mRNA in cultured VSMCs and in vivo in rat carotid arteries by 9-fold and 4-fold, respectively...
  14. doi siRNA-targeted COL8A1 inhibits proliferation, reduces invasion and enhances sensitivity to D-limonence treatment in hepatocarcinoma cells
    Yongfu Zhao
    Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
    IUBMB Life 61:74-9. 2009
    The COL8A1 (collagen type VIII, alpha-1) gene, which encodes the alpha 1 chain of collagen, type VIII, may modulate migration, proliferation and adherence of various cells...
  15. ncbi Connexin43 deficiency causes dysregulation of coronary vasculogenesis
    Diana L Walker
    Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Building 50 Room 4537, Bethesda, MD 20892 8019, USA
    Dev Biol 284:479-98. 2005
    ....
  16. ncbi Crystal structure of the collagen alpha1(VIII) NC1 trimer
    Marc Kvansakul
    Department of Biological Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Matrix Biol 22:145-52. 2003
    ....
  17. ncbi Expression of type VIII collagen during morphogenesis of the chicken and mouse heart
    M L Iruela-Arispe
    Department of Biological Structure, University of Washington, Seattle 98195
    Dev Biol 144:107-18. 1991
    ..The contribution of this collagen to cardiac morphogenesis might reside, in part, in its ability to influence the differentiation of the myocardium and formation of the cardiac valves...