Cnr2

Summary

Gene Symbol: Cnr2
Description: cannabinoid receptor 2 (macrophage)
Alias: CB-2, CB2, CB2-R, cannabinoid receptor 2, cannabinoid receptor 2 (spleen)
Species: mouse

Top Publications

  1. pmc Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection
    Peer W F Karmaus
    Cell and Molecular Biology Program, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    J Leukoc Biol 90:983-95. 2011
  2. pmc Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    Dingzhi Wang
    Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA
    Cancer Res 68:6468-76. 2008
  3. pmc The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling
    B C Paria
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Proc Natl Acad Sci U S A 92:9460-4. 1995
  4. ncbi Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor
    N E Buckley
    Basic Neuroscience Program, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Pharmacol 396:141-9. 2000
  5. ncbi Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation
    B C Paria
    Department of Pediatrics, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    J Biol Chem 276:20523-8. 2001
  6. ncbi Cloning and molecular characterization of the rat CB2 cannabinoid receptor
    Sean M Brown
    RW Johnson Pharmaceutical Research Institute, 3210 Merryfield Row, San Diego, CA 92121, USA
    Biochim Biophys Acta 1576:255-64. 2002
  7. ncbi Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation
    Yoonkyung Do
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 173:2373-82. 2004
  8. pmc CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
    Mohab M Ibrahim
    Department of Anesthesiology, University of Arizona College of Medicine, Tucson, AZ 85724 5114, USA
    Proc Natl Acad Sci U S A 102:3093-8. 2005
  9. ncbi Antifibrogenic role of the cannabinoid receptor CB2 in the liver
    Boris Julien
    INSERM, U581, Creteil, F 94010 France
    Gastroenterology 128:742-55. 2005
  10. ncbi Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons
    G Wotherspoon
    Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK
    Neuroscience 135:235-45. 2005

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. pmc Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection
    Peer W F Karmaus
    Cell and Molecular Biology Program, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    J Leukoc Biol 90:983-95. 2011
    ..Collectively, these findings implicate a role for CB(1) and CB(2) on APCs in regulating immune responses and immune homeostasis...
  2. pmc Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    Dingzhi Wang
    Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA
    Cancer Res 68:6468-76. 2008
    ..These results indicate that the endogenous cannabinoid system may represent a potential therapeutic target for prevention or treatment of colorectal cancer...
  3. pmc The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling
    B C Paria
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Proc Natl Acad Sci U S A 92:9460-4. 1995
    ..reverse transcription-coupled PCR, we demonstrated that both brain and spleen type cannabinoid receptor (CB1-R and CB2-R, respectively) mRNAs are expressed in the preimplantation mouse embryo...
  4. ncbi Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor
    N E Buckley
    Basic Neuroscience Program, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Pharmacol 396:141-9. 2000
    ..Furthermore, we conclude that the cannabinoid CB(2) receptor knockout mouse is a useful animal model in which to study the role of the cannabinoid system in immunoregulation...
  5. ncbi Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation
    B C Paria
    Department of Pediatrics, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    J Biol Chem 276:20523-8. 2001
    ..embryo development became asynchronous in mice that are deficient in brain-type (CB1) and/or spleen-type (CB2) cannabinoid receptor genes...
  6. ncbi Cloning and molecular characterization of the rat CB2 cannabinoid receptor
    Sean M Brown
    RW Johnson Pharmaceutical Research Institute, 3210 Merryfield Row, San Diego, CA 92121, USA
    Biochim Biophys Acta 1576:255-64. 2002
    ..The importance of the carboxy terminus in regulating CB2 receptor desensitization and internalization is well-established...
  7. ncbi Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation
    Yoonkyung Do
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 173:2373-82. 2004
    The precise role of cannabinoid receptors (CB)1 and CB2, as well as endogenous ligands for these receptors, on immune cells remains unclear...
  8. pmc CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
    Mohab M Ibrahim
    Department of Anesthesiology, University of Arizona College of Medicine, Tucson, AZ 85724 5114, USA
    Proc Natl Acad Sci U S A 102:3093-8. 2005
    ..This mechanism allows for the local release of beta-endorphin, where CB(2) receptors are present, leading to anatomical specificity of opioid effects...
  9. ncbi Antifibrogenic role of the cannabinoid receptor CB2 in the liver
    Boris Julien
    INSERM, U581, Creteil, F 94010 France
    Gastroenterology 128:742-55. 2005
    ..Cannabinoids are the active components of marijuana and act via 2 G-protein-coupled receptors, CB1 and CB2. Here, we investigated whether liver fibrogenic cells are a target of cannabinoids.
  10. ncbi Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons
    G Wotherspoon
    Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK
    Neuroscience 135:235-45. 2005
    We have localized cannabinoid receptor 2 protein in rat and mouse somatic sensory nervous system, using an antibody that recognizes mouse cannabinoid receptor 2...
  11. pmc Peripheral cannabinoid receptor, CB2, regulates bone mass
    Orr Ofek
    Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 103:696-701. 2006
    ..receptors, the predominantly central cannabinoid receptor type 1 (CB1) and peripheral cannabinoid receptor type 2 (CB2)...
  12. ncbi Formation of B and T cell subsets require the cannabinoid receptor CB2
    David Ziring
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Immunogenetics 58:714-25. 2006
    ..The peripheral cannabinoid receptor CB2 is highly expressed in immune cell types (macrophages, dendritic cells, and B cells), and pharmacologically alters ..
  13. ncbi Cannabinoid receptors as novel targets for the treatment of melanoma
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    FASEB J 20:2633-5. 2006
    ..Human melanomas and melanoma cell lines express CB1 and CB2 cannabinoid receptors...
  14. pmc Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury
    Sandor Batkai
    Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    FASEB J 21:1788-800. 2007
    ..Activation of CB2 cannabinoid receptors by JWH133 protects against I/R damage by decreasing inflammatory cell infiltration, tissue ..
  15. ncbi CB2 cannabinoid receptors promote mouse neural stem cell proliferation
    Francisco Molina-Holgado
    The Wolfson Centre for Age Related Diseases, King s College London, Hodking Building, Guy s Campus, London SE1 1UL, UK
    Eur J Neurosci 25:629-34. 2007
    ..In the present study we investigated the expression of CB2 cannabinoid receptors and the effect of exogenous cannabinoids on neural stem/precursor cell proliferation...
  16. ncbi Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
    Katarzyna Maresz
    BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53226, USA
    Nat Med 13:492-7. 2007
    ..Together, our results demonstrate that the cannabinoid system within the CNS plays a critical role in regulating autoimmune inflammation, with the CNS directly suppressing T-cell effector function via the CB(2) receptor...
  17. ncbi Attenuation of allergic contact dermatitis through the endocannabinoid system
    Meliha Karsak
    Department of Molecular Psychiatry, University of Bonn, Germany
    Science 316:1494-7. 2007
    ..These results demonstrate a protective role of the endocannabinoid system in contact allergy in the skin and suggest a target for therapeutic intervention...
  18. doi The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, Complutense University, 28040 Madrid, Spain
    J Biol Chem 283:13320-9. 2008
    ....
  19. doi Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors
    Martin A Storr
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Mol Med (Berl) 86:925-36. 2008
    ..In conclusion, drugs targeting EC degradation offer therapeutic potential in the treatment of inflammatory bowel diseases. Furthermore, reduction of FAAH mRNA expression is involved in the pathophysiological response to colitis...
  20. doi Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type 2 cannabinoid receptor
    Aymen I Idris
    Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Endocrinology 149:5619-26. 2008
    ..The type 2 cannabinoid receptor (CB2) has been reported to regulate bone mass, but conflicting results have been reported with regard to its effects on ..
  21. pmc Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease
    Onintza Sagredo
    Departamento de Bioquímica y Biología Molecular and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Glia 57:1154-67. 2009
    ..Our results showed that only compounds able to activate CB2 receptors were capable of protecting striatal projection neurons from malonate-induced death...
  22. pmc Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids
    Joao P Pereira
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:403-11. 2009
    ..Instead, cannabinoid receptor 2 (CB2), a Galpha(i) protein-coupled receptor upregulated in immature B cells, was required for sinusoidal ..
  23. pmc The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
    Lauren S Whyte
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, United Kingdom
    Proc Natl Acad Sci U S A 106:16511-6. 2009
    ..In addition, this study also brings to light an effect of both the endogenous ligand, LPI, on osteoclasts and of the cannabis constituent, CBD, on osteoclasts and bone turnover in vivo...
  24. pmc The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment
    Rudolf Schicho
    Division of Gastroenterology, Department of Medicine, Snyder Institute of Infection, Immunity and Inflammation III, Alberta, Canada
    Inflamm Bowel Dis 17:1651-64. 2011
    ....
  25. ncbi Molecular characterization of a peripheral receptor for cannabinoids
    S Munro
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 365:61-5. 1993
    ..Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen...
  26. ncbi Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation
    S J Carlisle
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond 23298 0678, USA
    Int Immunopharmacol 2:69-82. 2002
    ..P388D, macrophage-like cells, and neonatal rat brain cortex microglia expressed the cannabinoid receptor type 2 (CB2) differentially in relation to cell activation...
  27. ncbi Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol
    Meritxell Alberich Jorda
    Institute for Hematology, Erasmus University Rotterdam, The Netherlands
    Blood 99:2786-93. 2002
    b>Cb2 is a novel protooncogene encoding the peripheral cannabinoid receptor. Previous studies demonstrated that 2 distinct noncoding first exons exist: exon-1A and exon-1B, which both splice to protein-coding exon-2...
  28. pmc Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
    M Llanos Casanova
    Project on Cellular and Molecular Biology and Gene Therapy, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid, Spain
    J Clin Invest 111:43-50. 2003
    ..Abrogation of EGF-R function was also observed in cannabinoid-treated tumors. These results support a new therapeutic approach for the treatment of skin tumors...
  29. ncbi Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium
    Edward S Kimball
    Enterology Research Team, Johnson and Johnson Pharmaceutical Research and Development, PA 19477 0776, USA
    Am J Physiol Gastrointest Liver Physiol 291:G364-71. 2006
    ..The demonstration of CB1R agonist effects in colitis support the neurogenic nature of the OM-induced colitis model and reinforce the importance of neuronal activation in intestinal inflammation...
  30. ncbi Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    FASEB J 20:2405-7. 2006
    ..In contrast, the CB2 cannabinoid receptor is abundant in the immune system and shows a restricted expression pattern in brain cells...
  31. ncbi Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages
    Somnath Mukhopadhyay
    Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    J Neuroimmunol 181:82-92. 2006
    ..Forskolin or dibutyryl cyclic AMP increased CB(2) receptor immunoreactivity, suggesting the involvement of the cyclic AMP-protein kinase A-Cyclic AMP response element pathway in the regulation of CB(2) receptor levels...
  32. pmc CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion
    Mohanraj Rajesh
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    Am J Physiol Heart Circ Physiol 293:H2210-8. 2007
    ....
  33. pmc Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis
    Natalie E Freeman-Anderson
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    J Lipid Res 49:2338-46. 2008
    ..b>Cannabinoid receptor 2 (CB2), the predominant macrophage cannabinoid receptor, modulates several macrophage processes associated ..
  34. doi CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    J Mol Cell Cardiol 46:612-20. 2009
    ..Our data suggest that JWH-133 administration during ischemia reduces the infarct size in a mouse model of myocardial ischemia/reperfusion through a direct cardioprotective activity on cardiomyocytes and neutrophils...
  35. doi Regulation and possible role of endocannabinoids and related mediators in hypercholesterolemic mice with atherosclerosis
    Fabrizio Montecucco
    Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Atherosclerosis 205:433-41. 2009
    ....
  36. doi The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy
    Nicole Defer
    INSERM, Unité 955, Creteil, France
    FASEB J 23:2120-30. 2009
    ..Ex vivo studies have demonstrated the cardioprotective anti-inflammatory effect of the cannabinoid type 2 (CB2) receptor agonists within hours after IR...
  37. pmc Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands
    Q R Liu
    Mol Neurobiol Branch, NIDA IRP, NIH, Baltimore, MD, USA
    Genes Brain Behav 8:519-30. 2009
    ..endocannabinoids and marijuana activate two well-characterized cannabinoid receptors (CB-Rs), CB1-Rs and CB2-Rs...
  38. doi CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages
    Ki Hoon Han
    Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, Republic of Korea
    Cardiovasc Res 84:378-86. 2009
    We investigated the mechanism by which cannabinoid receptors-1 (CB1) and -2 (CB2) modulate inflammatory activities of macrophages.
  39. pmc Cannabinoid receptor type 2 (CB2) deficiency alters atherosclerotic lesion formation in hyperlipidemic Ldlr-null mice
    Courtney D Netherland
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0581, USA
    Atherosclerosis 213:102-8. 2010
    To determine if cannabinoid receptor 2 (CB2) plays a role in atherosclerosis, we investigated the effects of systemic CB2 gene deletion on hyperlipidemia-induced atherogenesis in low density lipoprotein receptor-deficient (Ldlr(-/-)) mice.
  40. doi Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis
    Zhi Yin Lou
    Institute of Neurology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    Mol Immunol 49:453-61. 2011
    ..These results indicate that manipulation of CB(2)R may have therapeutic value in MS, but its complexity remains to be considered and studied for further clinical application...
  41. pmc Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    Z Jarai
    Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 96:14136-41. 1999
    ..Two cannabinoid receptors, CB1 and CB2, have been cloned, and studies with the selective CB1 receptor antagonist SR141716A have implicated peripherally ..
  42. ncbi Aberrant cannabinoid signaling impairs oviductal transport of embryos
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Med 10:1074-80. 2004
    ..Besides uncovering a new regulatory mechanism, this study could be clinically relevant to ectopic pregnancy...
  43. ncbi The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    Joseph Tam
    Bone Laboratory, Hadassah School of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    FASEB J 22:285-94. 2008
    ..Elevation of bone 2-AG apparently suppresses NE release from bone sympathetic terminals, thus alleviating the inhibition of bone formation. The involvement of osteoblastic CB2 signaling in this process is minimal, if any.
  44. pmc Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury
    M Zhang
    Center for Substance Abuse Research, Temple University School of Medicine, 231 OMS, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Neuroscience 152:753-60. 2008
    ..The greatest degree of neuroprotection was obtained by combining an inhibitor of CB(1) activation with an exogenous CB(2) agonist...
  45. pmc Cannabinoid ligand-receptor signaling in the mouse uterus
    S K Das
    Department of Physiology, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City 66160 7338, USA
    Proc Natl Acad Sci U S A 92:4332-6. 1995
    ..we demonstrate that the brain-type cannabinoid receptor (CB1-R) mRNA, but not the spleen-type cannabinoid receptor (CB2-R) mRNA, is expressed in the mouse uterus and that this organ has the capacity to synthesize the putative ..
  46. ncbi Leukemic predisposition of pSca-1/Cb2 transgenic mice
    Marieke Joosten
    The Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Exp Hematol 30:142-9. 2002
    The gene encoding the peripheral cannabinoid receptor Cb2 is located in the common virus integration site Evi11 and is associated with hematopoietic malignancies in mice...
  47. doi Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase
    D De Filippis
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 20:919-27. 2008
    ..Despite its proven anti-oxidant and anti-inflammatory properties, cannabidiol may be of limited use for the treatment of sepsis-induced ileus...
  48. doi Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo
    Friedrich Felix Hoyer
    Department for Cardiology, University of Bonn, Germany
    J Mol Cell Cardiol 51:1007-14. 2011
    ..cannabinoid-1 receptors (CB1) with subsequent psychoactive effects as well as peripheral cannabinoid-2 receptors (CB2)...
  49. pmc Cannabinoid receptor CB2 protects against balloon-induced neointima formation
    Filippo Molica
    Division of Cardiology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Am J Physiol Heart Circ Physiol 302:H1064-74. 2012
    ..In conclusion, pharmacological activation or genetic deletion of CB(2) receptors modulate neointima formation via protective effects in macrophages and smooth muscle cells...
  50. pmc Modulating the endocannabinoid system in human health and disease--successes and failures
    Pal Pacher
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
    FEBS J 280:1918-43. 2013
    ....
  51. pmc Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis
    Sofia Sisay
    Neuroimmunology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS ONE 8:e76907. 2013
    ..Studies using C57BL/10 and C57BL/6 (Cnr2 (tm1Zim)) CB2 cannabinoid receptor knockout mice have demonstrated an immune-augmenting effect in experimental ..
  52. doi The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy
    Georg D Duerr
    Department of Cardiac Surgery, University Clinical Centre Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Basic Res Cardiol 109:425. 2014
    ..Endocannabinoids and the cannabinoid receptor CB2 have been claimed to be involved, but their potential role in cardioprotection is not well understood...
  53. pmc Cnr2 deficiency confers resistance to inflammation-induced preterm birth in mice
    Xiaofei Sun
    Division of Reproductive Sciences X S, Y L, S K D, Perinatal Institute, and Division of Cellular and Molecular Immunology M C, C L K, S D, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229
    Endocrinology 155:4006-14. 2014
    ..A G protein-coupled cannabinoid receptor 2 (CB2), encoded by Cnr2, is expressed in various immune cells and was shown to modulate immune responses...
  54. pmc Expression Analysis of CB2-GFP BAC Transgenic Mice
    Anne Caroline Schmöle
    Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany
    PLoS ONE 10:e0138986. 2015
    ..As CB2 is primarily expressed on immune cells such as B cells, T cells, macrophages, dendritic cells, and microglia, it is ..
  55. pmc CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory
    Yong Li
    Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
    Neural Plast 2016:9817089. 2016
    ..However, recent discoveries of CB2 cannabinoid receptors in the brain demand accurate determination of whether and how CB2 receptors are involved in ..
  56. pmc The major central endocannabinoid directly acts at GABA(A) receptors
    Erwin Sigel
    Institute of Biochemistry and Molecular Medicine, University of Bern, CH 3012 Bern, Switzerland
    Proc Natl Acad Sci U S A 108:18150-5. 2011
    ..The identification of a functional binding site for 2-AG in the GABA(A) receptor may have far-reaching consequences for the study of locomotion and sedation...
  57. pmc CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling
    Javier Palazuelos
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Instituto Universitario de Investigación en Neuroquímica, and Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 287:1198-209. 2012
    ..Altogether, these findings provide a mechanism of action and a rationale for the use of nonpsychotomimetic CB(2) receptor-selective ligands as a novel strategy for the control of NP cell proliferation and neurogenesis...
  58. doi The inhibitory action of exo- and endocannabinoids on [³H]GABA release are mediated by both CB₁and CB₂receptors in the mouse hippocampus
    Romeo D Ando
    Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Neurochem Int 60:145-52. 2012
    ..In addition, in the effect of the exocannabinoid THC and the endocannabinoid 2-AG, non-CB(1), probably CB(2)-like receptors are also involved...
  59. doi Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear
    Kwang Choi
    Center for the Study of Traumatic Stress, Dept of Psychiatry, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    J Psychiatr Res 46:882-9. 2012
    ..developmental and disease-related expression pattern of the cannabinoid receptor 1 (CB1) and the cannabinoid receptor 2 (CB2) genes in the dorsolateral prefrontal cortex (PFC) of humans...
  60. pmc Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression
    Sabina Adhikary
    Departments of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 120:3741-9. 2012
    Administration of cannabinoid receptor 2 (CB2R) agonists in inflammatory and autoimmune disease and CNS injury models results in significant attenuation of clinical disease, and reduction of inflammatory mediators...
  61. doi Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
    Xuqin Zheng
    Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province 210029, China
    Biochem Biophys Res Commun 436:377-81. 2013
    ..Our findings imply that pharmacological manipulation of CB2R may provide therapeutic possibilities to treat metabolic diseases associated with lipid dysregulation. ..
  62. ncbi Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development
    Z M Yang
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Biol Reprod 55:756-61. 1996
    ..of guanine nucleotide regulatory protein-coupled brain-type and spleen-type cannabinoid receptors (CB1-R and CB2-R, respectively) provide evidence that many of the effects of cannabinoids are mediated via these receptors...
  63. pmc The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11
    P J Valk
    Institute of Hematology, Erasmus University Rotterdam, The Netherlands
    J Virol 71:6796-804. 1997
    ..The genes encoding the peripheral cannabinoid receptor (Cnr2) and alpha-L-fucosidase (Fuca1) were identified near the integration site by using a novel exon trapping system...
  64. ncbi Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, I 00133 Italy
    Endocrinology 144:20-8. 2003
    ..Taken together, it can be suggested that the endocannabinoid network plays a role in the hormonal regulation of male fertility...
  65. ncbi The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner
    Meritxell Alberich Jorda
    Erasmus MC, Department of Hematology, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Blood 104:526-34. 2004
    b>Cb2, the gene encoding the peripheral cannabinoid receptor, is located in a common virus integration site and is overex-pressed in retrovirally induced murine myeloid leukemias...
  66. ncbi Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans
    H Ishiguro
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Pharmacogenomics J 7:380-5. 2007
    We tested if cannabinoid type 2 receptor (CB2) in the central nervous system plays a role in alcohol abuse/dependence in animal model and then examined an association between the CB2 gene polymorphism and alcoholism in human...
  67. pmc The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
    Jennifer L Shoemaker
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 101:87-98. 2007
    ..Cannabinoids produce anti-inflammatory actions via cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), and delay the progression of neuroinflammatory diseases...
  68. pmc Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells
    Shuxian Jiang
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e641. 2007
    ....
  69. ncbi Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis
    Akiko Shiratsuchi
    Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Immunol Cell Biol 86:179-84. 2008
    ..An agonist of the cannabinoid receptors CB1 and CB2 also stimulated the phagocytosis of zymosan...
  70. ncbi Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of Delta9-tetrahydrocannabinol
    John P Buchweitz
    Department of Pharmacology and Toxicology, and Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Leukoc Biol 83:785-96. 2008
    ..Collectively, the immune and airway epithelial cell responses to PR8 challenge in Delta(9)-THC-treated CB(1)-/-/CB(2)-/- and wild-type mice indicated the involvement of CB(1)/CB(2) receptor-dependent and -independent mechanisms...
  71. pmc Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes
    Marisela Agudelo
    Department of Molecular Medicine, School of Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Neuroimmune Pharmacol 3:35-42. 2008
    ..These results suggest that cannabinoids bias toward Th2-type immunity by directly inducing B cell class switching from IgM to IgE through a mechanism involving CB(2) receptors...
  72. pmc Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity
    Pingwei Zhao
    Forbes Norris ALS MDA Research Center, California Pacific Medical Center Research Institute, 475 Brannan St, Suite 220, San Francisco, CA 94107, USA
    Eur J Neurosci 27:572-9. 2008
    ..To our knowledge, this is the first demonstration of presymptomatic changes in trafficking of receptors that are in direct control of excitotoxicity and death in a mouse model of ALS...
  73. pmc Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption
    E S Onaivi
    Department of Biology, William Paterson University, Wayne, New Jersey, USA
    Ann N Y Acad Sci 1139:426-33. 2008
    ..There was a reduction in CNR2 gene expression in the ventral mid-brain region of mice that developed alcohol preference, but not in those that ..
  74. pmc Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, New Jersey, USA
    Ann N Y Acad Sci 1139:434-49. 2008
    ..Many laboratories were not able to detect the presence of CB2 cannabinoid receptors (CB2-Rs) in healthy brains, but CB2-R expression has been demonstrated in rat microglial ..
  75. pmc CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury
    Ming Zhang
    Department of Physiology, Temple University School of Medicine, 208 MRB, 3420 N Broad Street, Philadelphia, PA 19140, USA
    Microvasc Res 78:86-94. 2009
    ..In conclusion, CB(2) activation contributed to protecting the brain through the attenuation of cerebral microcirculatory dysfunction during cerebral I/R injury...
  76. pmc AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors
    Douglas Thewke
    Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, 807 University Parkway, Johnson City, TN 37614, USA
    Biochem Biophys Res Commun 381:181-6. 2009
    ..Macrophages lacking the type 2 cannabinoid receptor (CB2) are partially resistant to apoptosis induced by 7-ketocholesterol (7KC)...
  77. doi Endocannabinoids anandamide and its cannabinoid receptors in liver fibrosis after murine schistosomiasis
    Hongyan Liu
    Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 29:182-6. 2009
    ..Endogenous endocannabinoids may be involved in the development of schistosoma-induced liver fibrosis...
  78. pmc The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis
    Paola Grimaldi
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 106:11131-6. 2009
    ....
  79. pmc CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis
    Balázs Csóka
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 4:e6409. 2009
    ..Here we examined the role of CB(2) receptors in regulating the host's response to sepsis...
  80. doi Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity
    Javier Palazuelos
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Spain
    Brain 132:3152-64. 2009
    ....
  81. pmc The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin
    Barbara L F Kaplan
    Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Pathol 38:382-92. 2010
    ..These results suggest that T-cell responses are not universally exaggerated in CB(1)/CB(2) null mice...
  82. pmc Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis
    Amélie Servettaz
    Universite Paris Descartes, Faculte de Medecine, Laboratoire d Immunologie, EA 1833, IFR Alfred Jost, 75679 Paris Cedex 14, France
    Am J Pathol 177:187-96. 2010
    ..Experiments were also performed in mice deficient for CB2 receptors (Cnr2(-/-))...
  83. pmc CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts
    Orr Ofek
    Bone Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel
    J Bone Miner Res 26:308-16. 2011
    b>CB2 is a Gi protein-coupled receptor activated by endo- and phytocannabinoids, thus inhibiting stimulated adenylyl cyclase activity. CB2 is expressed in bone cells and Cb2 null mice show a marked age-related bone loss...
  84. doi Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age
    J Agudo
    Center of Animal Biotechnology and Gene Therapy, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Diabetologia 53:2629-40. 2010
    ..During obesity, CB2R is involved in the development of adipose tissue inflammation and fatty liver. We examined the long-term effects of CB2R deficiency in glucose metabolism...
  85. doi Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells
    Heather L Hutchins
    Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907, USA
    J Nutr Biochem 22:195-200. 2011
    Anandamide (AEA) is an endogenous agonist for the cannabinoid receptor 2 (CB2) which is expressed in osteoblasts...
  86. ncbi Expression and function of cannabinoid receptors in mouse islets
    Chen Li
    Diabetes Research Group, King s College London, London, UK
    Islets 2:293-302. 2010
    ..CB1 and CB2 mRNA and protein expression by islets was detected by RT-PCR and western blotting respectively, and cellular ..
  87. pmc Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice
    Antonio Ortega-Alvaro
    Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, Albacete, Spain
    Neuropsychopharmacology 36:1489-504. 2011
    ..Pharmacological manipulation of CB(2)r may merit further study as a potential therapeutic target for the treatment of schizophrenia-related disorders...
  88. pmc Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice
    Florian Willecke
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 6:e19405. 2011
    Strong evidence supports a protective role of the cannabinoid receptor 2 (CB(2)) in inflammation and atherosclerosis. However, direct proof of its involvement in lesion formation is lacking...
  89. doi Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 31:860-70. 2011
    ..To investigate the differences between CB(1) and CB(2) in the hepatic response to chronic alcohol intake, we examined CB knockout mice (CB(1)(-/-), CB(2)(-/-))...
  90. pmc Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA
    Nat Neurosci 14:1160-6. 2011
    ..in wild-type and CB(1) receptor knockout (CB(1)(-/-), also known as Cnr1(-/-)) mice, but not in CB(2)(-/-) (Cnr2(-/-)) mice...
  91. pmc Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone
    Jagan R Muppidi
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Exp Med 208:1941-8. 2011
    ..Previous work demonstrated that mice deficient in cannabinoid receptor 2 (CB2) have decreased numbers of MZ B cells but it has been unclear whether CB2 regulates MZ B cell ..
  92. ncbi 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2
    Barbara L F Kaplan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, 48824, USA
    J Leukoc Biol 77:966-74. 2005
    2-Arachidonoyl-glycerol (2-AG), an endogenous ligand for cannabinoid receptor types 1 and 2 (CB1 and CB2), has previously been demonstrated to modulate immune functions including suppression of interleukin-2 expression and nuclear factor ..
  93. ncbi Involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in oxazolone-induced contact dermatitis in mice
    Saori Oka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamihara, Kanagawa 199 0195, Japan
    J Immunol 177:8796-805. 2006
    ..possible involvement of 2-arachidonoylglycerol (2-AG), an endogenous ligand for the cannabinoid receptors (CB1 and CB2), in contact dermatitis in mouse ear was investigated...
  94. pmc Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, New Jersey, USA
    PLoS ONE 3:e1640. 2008
    ..Many laboratories were not able to detect the presence of cannabinoid CB2 receptors (CB2-Rs) in healthy brains, but there has been demonstration of CB2-R expression in rat microglial cells ..
  95. pmc The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
    Duo Zheng
    Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 68:3992-8. 2008
    ..These data provide direct evidence indicating that the CB1/2 receptors play a key role in UV-induced inflammation and skin cancer development...
  96. pmc Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Delta9-tetrahydrocannabinol
    Alison E B Springs
    Centre for Integrative Toxicology, Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824 1317, USA
    J Leukoc Biol 84:1574-84. 2008
    The role of cannabinoid receptors, CB1 and CB2, in immune competence and modulation by Delta9-tetrahydrocannabinol (Delta9-THC) was investigated in CB1(-/-)/CB2(-/-) mice...
  97. doi CB(2) cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB(2) receptor in pain
    Eszter Páldy
    Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt 62, H 6726 Szeged, Hungary
    Neurochem Int 53:309-16. 2008
    ..Our data demonstrate that the SR144528 caused pronounced decrease in the activity of MOR is mediated via CB(2) cannabinoid receptors...
  98. pmc Genetic loss of Faah compromises male fertility in mice
    Xiaofei Sun
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biol Reprod 80:235-42. 2009
    ..Collectively, the results show that aberrant endocannabinoid signaling via CNR1 impairs normal sperm function. Besides unveiling a new regulatory mechanism of sperm function, this study has clinical significance in male fertility...
  99. pmc Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain
    Ildiko Racz
    Institute of Molecular Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 28:12125-35. 2008
    ....
  100. pmc Interferon-gamma is a critical modulator of CB(2) cannabinoid receptor signaling during neuropathic pain
    Ildiko Racz
    Institute of Molecular Psychiatry and Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 28:12136-45. 2008
    ..These animals no longer show the enhanced manifestations of neuropathic pain observed in CB(2) knock-outs. These data clearly demonstrate that the CB(2) receptor-mediated control of neuropathic pain is IFN-gamma dependent...

Research Grants9

  1. IL-2 Suppression by Endocannabinoid Activation of PPARgamma
    NORBERT EDWARD KAMINSKI; Fiscal Year: 2010
    ..of the nuclear receptor, peroxisome proliferator activated receptor gamma (PPARgamma), independently of CB1 and CB2. Additional results are present suggesting that the specific mechanism involves the disruption of the nuclear ..
  2. REPRESSION OF T CELL ACTIVATION BY ENDOCANNABINOIDS
    Norbert Kaminski; Fiscal Year: 2003
    ..goals of this 4 year research plan are two-fold: (a) to characterize the role of cannabinoid receptors CB1 and CB2 in the modulation of T-cell function by endogenous eicosinoid-like cannabinoids; and (b) to elucidate the signal ..
  3. The role of CB2 receptors in oxLDL-induced apopotosis and atherogenesis
    Douglas Thewke; Fiscal Year: 2006
    ..we have begun to examine the hypothesis that arachidonyl oxysterols produce these effects via the cannabinoid 2 (CB2) receptor...
  4. Regulation of stearoyl-CoA desaturases by oleate
    Douglas Thewke; Fiscal Year: 2004
    ..Ectotopic expression of SREBPs or other trans-acting factors will be used to determine their contribution to oleate regulation of SCD transcription. ..
  5. Molecular basis of arsenic-induced cell transformation
    Zigang Dong; Fiscal Year: 2007
    ..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
  6. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2007
    ....
  7. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2009
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  8. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Zigang Dong; Fiscal Year: 2010
    ..abstract_text> ..
  9. Study on Ultraviolet-induced Signal Transduction
    Zigang Dong; Fiscal Year: 2010
    ..These preclinical studies are designed to lead to the development of new strategies for the chemoprevention of human skin cancers. ..