Clec3b

Summary

Gene Symbol: Clec3b
Description: C-type lectin domain family 3, member b
Alias: Tna, tetranectin, plasminogen kringle 4-binding protein, tetranectin (plasminogen binding protein)
Species: mouse

Top Publications

  1. doi Delayed fracture healing in tetranectin-deficient mice
    Kousuke Iba
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Bone Miner Metab 31:399-408. 2013
  2. pmc A potential role for tetranectin in mineralization during osteogenesis
    U M Wewer
    Laboratory of Molecular Pathology, University Institute of Pathological Anatomy, Copenhagen, Denmark
    J Cell Biol 127:1767-75. 1994
  3. ncbi Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator
    Uffe B Westergaard
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Denmark
    Eur J Biochem 270:1850-4. 2003
  4. ncbi Expression and localization of annexin VII (synexin) in muscle cells
    S Selbert
    Max Planck Institut fur Biochemie, Martinsried, Germany
    J Cell Sci 108:85-95. 1995
  5. ncbi Cloning of a cDNA encoding murine tetranectin
    C B Sørensen
    Protein Chemistry Laboratory, University of Aarhus, Denmark
    Gene 152:243-5. 1995
  6. ncbi Mouse tetranectin: cDNA sequence, tissue-specific expression, and chromosomal mapping
    K Ibaraki
    Bone Research Branch, National Institute of Dental Research National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Mamm Genome 6:693-6. 1995
  7. ncbi Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4, Room 329, Bethesda, Maryland 20892 0460, USA
    Mamm Genome 7:787-8. 1996
  8. ncbi Assignment of the gene for human tetranectin (TNA) to chromosome 3p22-->p21.3 by somatic cell hybrid mapping
    M E Durkin
    Institute of Molecular Pathology, University of Copenhagen, Denmark
    Cytogenet Cell Genet 76:39-40. 1997
  9. ncbi Cloning of the murine tetranectin gene and 5'-flanking region
    C B Sørensen
    Protein Chemistry Laboratory, University of Aarhus, Science Park, Aarhus C, Denmark
    Gene 201:199-202. 1997
  10. ncbi Tetranectin is a novel marker for myogenesis during embryonic development, muscle regeneration, and muscle cell differentiation in vitro
    U M Wewer
    Institute of Molecular Pathology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Dev Biol 200:247-59. 1998

Scientific Experts

  • Kousuke Iba
  • U M Wewer
  • M Hermann
  • Uffe B Westergaard
  • M E Durkin
  • R Albrechtsen
  • C B Sørensen
  • C A Kozak
  • A Draxl
  • P Hengster
  • R Margreiter
  • D Pirkebner
  • K Ibaraki
  • Christian W Heegaard
  • Mikkel H Andersen
  • Sergey N Fedosov
  • Torben E Petersen
  • T E Petersen
  • L Berglund
  • S Selbert
  • M F Young
  • F C Nielsen
  • E Engvall
  • F Loechel
  • B J Gilpin
  • W Kuang
  • S L Naylor
  • L Sangameswaran
  • M Stewart
  • P Fischer
  • D Pongratz
  • A A Noegel
  • P Schjørring

Detail Information

Publications14

  1. doi Delayed fracture healing in tetranectin-deficient mice
    Kousuke Iba
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Bone Miner Metab 31:399-408. 2013
    b>Tetranectin is a plasminogen-binding protein that enhances plasminogen activation, which has been suggested to play a role in tissue remodeling. Recently, we showed that tetranectin has a role in the wound-healing process...
  2. pmc A potential role for tetranectin in mineralization during osteogenesis
    U M Wewer
    Laboratory of Molecular Pathology, University Institute of Pathological Anatomy, Copenhagen, Denmark
    J Cell Biol 127:1767-75. 1994
    b>Tetranectin is a protein shared by the blood and the extracellular matrix. Tetranectin is composed of four identical, noncovalently bound polypeptides each with a molecular mass of approximately 21 kD...
  3. ncbi Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator
    Uffe B Westergaard
    Protein Chemistry Laboratory, Department of Molecular and Structural Biology, University of Aarhus, Denmark
    Eur J Biochem 270:1850-4. 2003
    In the search for new ligands for the plasminogen kringle 4 binding-protein tetranectin, it has been found by ligand blot analysis and ELISA that tetranectin specifically bound to the plasminogen-like hepatocyte growth factor and tissue-..
  4. ncbi Expression and localization of annexin VII (synexin) in muscle cells
    S Selbert
    Max Planck Institut fur Biochemie, Martinsried, Germany
    J Cell Sci 108:85-95. 1995
    ..The results obtained indicate a developmentally and Ca(2+)-regulated localization and expression of annexin VII and raise the possibility that annexin VII may play a role in excitation-contraction coupling in skeletal muscle...
  5. ncbi Cloning of a cDNA encoding murine tetranectin
    C B Sørensen
    Protein Chemistry Laboratory, University of Aarhus, Denmark
    Gene 152:243-5. 1995
    A full-length cDNA encoding murine tetranectin (TN) was isolated and cloned from a murine lung lambda ZAPII cDNA library...
  6. ncbi Mouse tetranectin: cDNA sequence, tissue-specific expression, and chromosomal mapping
    K Ibaraki
    Bone Research Branch, National Institute of Dental Research National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Mamm Genome 6:693-6. 1995
    b>Tetranectin is a plasminogen-binding tetrameric protein originally isolated from plasma...
  7. ncbi Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4, Room 329, Bethesda, Maryland 20892 0460, USA
    Mamm Genome 7:787-8. 1996
  8. ncbi Assignment of the gene for human tetranectin (TNA) to chromosome 3p22-->p21.3 by somatic cell hybrid mapping
    M E Durkin
    Institute of Molecular Pathology, University of Copenhagen, Denmark
    Cytogenet Cell Genet 76:39-40. 1997
    b>Tetranectin is a plasminogen-binding protein that is induced during the mineralization phase of osteogenesis...
  9. ncbi Cloning of the murine tetranectin gene and 5'-flanking region
    C B Sørensen
    Protein Chemistry Laboratory, University of Aarhus, Science Park, Aarhus C, Denmark
    Gene 201:199-202. 1997
    The gene encoding murine tetranectin (Tna) and its 5'-flanking region was isolated and cloned from a EMBL3 SP6/T7 genomic library...
  10. ncbi Tetranectin is a novel marker for myogenesis during embryonic development, muscle regeneration, and muscle cell differentiation in vitro
    U M Wewer
    Institute of Molecular Pathology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Dev Biol 200:247-59. 1998
    b>Tetranectin, a plasminogen-binding protein with a C-type lectin domain, is found in both serum and the extracellular matrix...
  11. pmc Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity
    K Iba
    The Institute of Molecular Pathology, University of Copenhagen, Copenhagen, Denmark
    Mol Cell Biol 21:7817-25. 2001
    b>Tetranectin is a plasminogen-binding, homotrimeric protein belonging to the C-type lectin family of proteins...
  12. ncbi In the search of potential human islet stem cells: is tetranectin showing us the way?
    M Hermann
    KMT Laboratory, University Hospital of Innsbruck, Innsbruck, Austria
    Transplant Proc 37:1322-5. 2005
    ..We describe the in vivo and in vitro localisation of tetranectin (TN) in human and murine islet cells. Similar to human islets, murine islets stain positive for tetranectin...
  13. doi Impaired cutaneous wound healing in mice lacking tetranectin
    Kousuke Iba
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Wound Repair Regen 17:108-12. 2009
    b>Tetranectin was originally purified from human serum on the basis of plasminogen kringle 4-binding properties...