Chuk

Summary

Gene Symbol: Chuk
Description: conserved helix-loop-helix ubiquitous kinase
Alias: AI256658, Chuk1, Fbx24, Fbxo24, IKBKA, IKK1, Ikka, NFKBIKA, inhibitor of nuclear factor kappa-B kinase subunit alpha, I kappa B kinase 1, I-kappa-B kinase alpha, IKK alpha, IKK-A, IkappaB kinase alpha, nuclear factor NF-kappa-B inhibitor kinase alpha
Species: mouse

Top Publications

  1. ncbi I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue
    Danielle L Drayton
    Department of Epidemiology and Public Health, Section of Immunobiology, Yale University School of Medicine, 60 College Street, New Haven, CT 06520, USA
    J Immunol 173:6161-8. 2004
  2. ncbi Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
  3. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
  4. pmc IKKα contributes to UVB-induced VEGF expression by regulating AP-1 transactivation
    Wen Dong
    Department of Pathophysiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, P R China
    Nucleic Acids Res 40:2940-55. 2012
  5. ncbi Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    M Delhase
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Science 284:309-13. 1999
  6. doi Nuclear factor-κB2/p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1α independent manner
    Andree Yeramian
    Department of Pathology and Molecular Genetics, Laboratori de Recerca Biomèdica, Hospital Universitari Arnau de Vilanova, Institut de Recerca Biomedica de Lleida, Univeristy of Lleida, IRBLLEIDA, Lleida, Spain
    Lab Invest 91:859-71. 2011
  7. ncbi A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity
    Zhimin Peng
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 282:21487-96. 2007
  8. ncbi Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation
    I M Verma
    Laboratory of Genetics, Salk Institute, San Diego, California 92186 5800, USA
    Genes Dev 9:2723-35. 1995
  9. ncbi CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain
    M A Connelly
    Department of Pathology, University at Stony Brook, NY 11794 5215, USA
    Cell Mol Biol Res 41:537-49. 1995
  10. pmc Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
    H Nakano
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Proc Natl Acad Sci U S A 95:3537-42. 1998

Research Grants

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue
    Danielle L Drayton
    Department of Epidemiology and Public Health, Section of Immunobiology, Yale University School of Medicine, 60 College Street, New Haven, CT 06520, USA
    J Immunol 173:6161-8. 2004
    ....
  2. ncbi Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
    ..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion...
  3. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
    ..Interactions of HMGB1 with TLR 2 and TLR 4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS...
  4. pmc IKKα contributes to UVB-induced VEGF expression by regulating AP-1 transactivation
    Wen Dong
    Department of Pathophysiology, Beijing Institute of Basic Medical Sciences, Beijing 100850, P R China
    Nucleic Acids Res 40:2940-55. 2012
    ..Targeting IKKα shows promise for the prevention of UVB-induced angiogenesis and the associated photodamage...
  5. ncbi Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    M Delhase
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Science 284:309-13. 1999
    ..Once activated, IKKbeta autophosphorylated at a carboxyl-terminal serine cluster. Such phosphorylation decreased IKK activity and may prevent prolonged activation of the inflammatory response...
  6. doi Nuclear factor-κB2/p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1α independent manner
    Andree Yeramian
    Department of Pathology and Molecular Genetics, Laboratori de Recerca Biomèdica, Hospital Universitari Arnau de Vilanova, Institut de Recerca Biomedica de Lleida, Univeristy of Lleida, IRBLLEIDA, Lleida, Spain
    Lab Invest 91:859-71. 2011
    ..These findings have important clinical implications for the improvement of EC prognosis before radiotherapy...
  7. ncbi A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity
    Zhimin Peng
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 282:21487-96. 2007
    ....
  8. ncbi Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation
    I M Verma
    Laboratory of Genetics, Salk Institute, San Diego, California 92186 5800, USA
    Genes Dev 9:2723-35. 1995
  9. ncbi CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain
    M A Connelly
    Department of Pathology, University at Stony Brook, NY 11794 5215, USA
    Cell Mol Biol Res 41:537-49. 1995
    ..This new gene, CHUK (conserved helix-loop-helix ubiquitous kinase), may represent the founding member of a new class of interacting ..
  10. pmc Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
    H Nakano
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Proc Natl Acad Sci U S A 95:3537-42. 1998
    ....
  11. ncbi NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    S Ghosh
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 16:225-60. 1998
    ..In this review, we discuss some of these recent findings and their implications for the study of NF-kappa B...
  12. ncbi Limb and skin abnormalities in mice lacking IKKalpha
    K Takeda
    Department of Biochemistry and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Science 284:313-6. 1999
    The gene encoding inhibitor of kappa B (IkappaB) kinase alpha (IKKalpha; also called IKK1) was disrupted by gene targeting. IKKalpha-deficient mice died perinatally...
  13. ncbi Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
    Y Hu
    Department of Pharmacology, Cancer Center, University of California San Diego, La Jolla, CA 92093 0636, USA
    Science 284:316-20. 1999
    ..Instead, loss of IKKalpha interfered with multiple morphogenetic events, including limb and skeletal patterning and proliferation and differentiation of epidermal keratinocytes...
  14. pmc IKK1-deficient mice exhibit abnormal development of skin and skeleton
    Q Li
    The Salk Institute, La Jolla, California 92037, USA
    Genes Dev 13:1322-8. 1999
    IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in vivo functions of IKK1, we generated IKK1-deficient mice...
  15. pmc Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements
    F R McKenzie
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York 11794 5215, USA
    Mol Cell Biol 20:2635-49. 2000
    ..Site-specific serine phosphorylation of IkappaBs by two IkappaB kinases (IKKalpha [also known as CHUK] and IKKbeta) targets them for proteolysis...
  16. pmc Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation
    Q Li
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Genes Dev 14:1729-33. 2000
    NF-kappaB activity is induced by cytokines, stress, and pathogens. IKK1 and IKK2 are critical IkappaB kinases in NF-kappaB activation. In this study mice lacking IKK1 and IKK2 died at E12...
  17. pmc IkappaB kinase alpha is essential for mature B cell development and function
    T Kaisho
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    J Exp Med 193:417-26. 2001
    ..Taken together, these results demonstrate that IKKalpha is critically involved in the prevention of cell death and functional development of mature B cells...
  18. pmc Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I
    A Matsushima
    Division of Informative Cytology, Institute for Enzyme Research, University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Exp Med 193:631-6. 2001
    ..These results demonstrate that both NIK and IKKalpha are essential for the induction of NF-kappaB through LTbetaR, whereas the NIK-IKKalpha pathway is dispensable in TNFR-I signaling...
  19. ncbi Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    U Senftleben
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 293:1495-9. 2001
    ..IKKalpha is therefore a pivotal component of a second NF-kappaB activation pathway based on regulated NF-kappaB2 processing rather than IkappaB degradation...
  20. ncbi IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
    Y Cao
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 107:763-75. 2001
    ..Thus, IKKalpha is a critical intermediate in a pathway that controls mammary epithelial proliferation in response to RANK signaling via cyclin D1...
  21. pmc Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha
    Kaoru Saijo
    Laboratory of Lymphocyte Signaling, Rockefeller University, New York, NY 10021, USA
    J Exp Med 195:1647-52. 2002
    ....
  22. pmc IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program
    Xiang Li
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877 0368, USA
    J Biol Chem 277:45129-40. 2002
    ..SOCS-3, a negative effector of STAT3 signaling, was found to be an NF-kappaB/IKK-induced gene, suggesting that IKK-mediated NF-kappaB activation can coordinately illicit negative effects on STAT signaling...
  23. ncbi Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression
    Yumi Yamamoto
    Division of Hematology Oncology, Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8594, USA
    Nature 423:655-9. 2003
    ..These results define a new nuclear role of IKK-alpha in modifying histone function that is critical for the activation of NF-kappaB-directed gene expression...
  24. ncbi A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression
    Vasiliki Anest
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nature 423:659-63. 2003
    ..These findings provide additional insight into the role of the IKK complex in NF-kappaB-regulated gene expression...
  25. pmc Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers
    Giuseppina Bonizzi
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    EMBO J 23:4202-10. 2004
    ..This site links induction of organogenic chemokines and other important regulatory molecules to activation of the alternative pathway...
  26. pmc Gene expression profiling in conjunction with physiological rescues of IKKalpha-null cells with wild type or mutant IKKalpha reveals distinct classes of IKKalpha/NF-kappaB-dependent genes
    Paul E Massa
    Genetics Graduate Program, The Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York 11794 5215, USA
    J Biol Chem 280:14057-69. 2005
    ....
  27. ncbi IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, California 92093, USA
    Nature 434:1138-43. 2005
    ..Inactivation of IKKalpha in mice enhances inflammation and bacterial clearance. Hence, the two IKK catalytic subunits have evolved opposing but complimentary roles needed for the intricate control of inflammation and innate immunity...
  28. pmc I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    Maria Grazia Ruocco
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 201:1677-87. 2005
    ..IKKbeta also protects osteoclasts and their progenitors from tumor necrosis factor alpha-induced apoptosis, and its loss in hematopoietic cells prevents inflammation-induced bone loss...
  29. ncbi IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive MC 0723, La Jolla, California 92093, USA
    Cell 121:977-90. 2005
    ..IKKbeta, therefore, orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis...
  30. ncbi Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]
    Chuan Jin Wu
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Cell Biol 8:398-406. 2006
    ..These results provide a mechanism for NEMO's critical role in IKK activation, and a key to understanding the link between cytokine-receptor proximal signalling and IKK and NF-kappaB activation...
  31. ncbi IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9
    Katsuaki Hoshino
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Suehiro cho 1 7 22, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nature 440:949-53. 2006
    ..Furthermore, IKK-alpha associated with and phosphorylated IRF-7. Our results identify a role for IKK-alpha in TLR7/9 signalling, and highlight IKK-alpha as a potential target for manipulating TLR-induced IFN-alpha production...
  32. ncbi Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease
    Thomas Enzler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Immunity 25:403-15. 2006
    ..Thus, both classical and alternative NF-kappaB signaling are important for development of lupus-like disease associated with BAFF overproduction. The same mechanisms may be involved in the pathogenesis of human SLE...
  33. pmc Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)
    Christopher R Ingraham
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 38:1335-40. 2006
    ..Histological and gene expression analyses indicate that the primary defect is in keratinocyte differentiation and proliferation. This study describes a new role for an IRF family member in epidermal development...
  34. ncbi Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
    Rebecca J Richardson
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Nat Genet 38:1329-34. 2006
    ..Our results indicate that Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch and that Irf6 and Sfn interact genetically in this process...
  35. pmc A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    Bigang Liu
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 103:17202-7. 2006
    ..Thus, overexpression of IKKalpha in the epidermis antagonized chemical carcinogen-induced mitogenic and angiogenic activities, repressing tumor progression and metastases...
  36. ncbi Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
    Ralph Gareus
    Institute for Genetics, Department of Mouse Genetics and Inflammation, University of Cologne, Zülpicher Str 47, 50674 Cologne, Germany
    Nat Cell Biol 9:461-9. 2007
    The kinase IKK1 (also known as IKKalpha) was previously reported to regulate epidermal development and skeletal morphogenesis by acting in keratinocytes to induce their differentiation in an NF-kappaB independent manner...
  37. pmc p63 induces key target genes required for epidermal morphogenesis
    Maranke I Koster
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:3255-60. 2007
    ..Our data provide insights into the role of DeltaNp63alpha in epidermal morphogenesis and homeostasis, and may contribute to our understanding of the pathogenic mechanisms underlying disorders caused by p63 mutations...
  38. ncbi Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin
    Jun Li Luo
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
    Nature 446:690-4. 2007
    ..Yet a mechanistic link between inflammation and metastasis is missing. We identified a role for IkappaB kinase alpha (IKKalpha), activated by receptor activator of NF-kappaB (RANK/TNFRSF11A), in mammary epithelial ..
  39. ncbi Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding
    Geoffrey Gloire
    GIGA Research, Virology Immunology, and Medical Chemistry Units, University of Liege, B 4000 Liege, Belgium
    J Biol Chem 282:21308-18. 2007
    ..We conclude that nuclear IKKalpha is required for p65 DNA binding in a gene-specific manner...
  40. ncbi Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell 129:903-14. 2007
    ..Our results identify a signaling pathway in which proinflammatory stimuli activate the IKKalpha-mediated sumoylation-dependent phosphorylation of PIAS1 for the immediate repression of inflammatory gene activation...
  41. pmc Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    Anamitra Ghosh
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:18754-9. 2007
    ..evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-..
  42. pmc IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 38:689-98. 2008
    ..active NF-kappaB (RelA/p65-p50) in the nucleus and transcription of pro-inflammatory genes, whereas the role of IKK alpha in perpetuation of sustained inflammatory response is not known...
  43. pmc IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis
    Nadine Bakkar
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 180:787-802. 2008
    ..Together, these data reveal a unique IKK/NF-kappaB signaling switch that functions to both inhibit differentiation and promote myotube homeostasis...
  44. pmc Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner
    Lun Song
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Exp Cell Res 314:2187-98. 2008
    ..Therefore, we concluded that both IKKalpha and IKKbeta can mediate arsenite-induced AP-1 transactivation through NF-kappaB activity-independent manner...
  45. ncbi IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas
    Rodolfo Moreno-Maldonado
    Department of Epithelial Biology, CIEMAT, Madrid, Spain
    Cell Cycle 7:2021-9. 2008
    ..The tight correlation between the properties of both murine and human ASCC variants strongly suggests that IKKalpha is responsible for the development of this human SCC variant...
  46. pmc IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver
    Tom Luedde
    Institute for Genetics, Centre for Molecular Medicine CMMC, and Cologne Excellence Cluster on Cellular Stress Responses in Aging associated Diseases CECAD, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Proc Natl Acad Sci U S A 105:9733-8. 2008
    ..Here, we show that the two IkappaB kinases, IKK1/IKKalpha and IKK2/IKKbeta, display distinct collaborative and specific functions that are essential to protect the ..
  47. pmc Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
    Atsushi Matsuzawa
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 321:663-8. 2008
    ..This two-stage signaling mechanism may apply to other innate immune receptors, accounting for spatial and temporal separation of MAPK and IKK signaling...
  48. pmc RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 40:147-58. 2009
    ..Rapid degradation of RelB signals for RelA/p65 activation and loss of its protective ability to suppress the proinflammatory cytokine release in lymphoid B cells...
  49. doi IKKalpha is required to maintain skin homeostasis and prevent skin cancer
    Bigang Liu
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Cell 14:212-25. 2008
    ..Thus, IKKalpha serves as an innate surveillant...
  50. pmc IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer
    Pascal Descargues
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, Cancer Center, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0723, USA
    EMBO J 27:2639-47. 2008
    b>IkappaB kinase alpha (IKKalpha), one of the two catalytic subunits of the IKK complex involved in nuclear factor kappaB (NF-kappaB) activation, also functions as a molecular switch that controls epidermal differentiation...
  51. doi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO...
  52. pmc A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression
    Lun Song
    Department of Cellular Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, People s Republic of China
    Biochim Biophys Acta 1803:323-32. 2010
    ..Notably, IKKa-dependent Cyclin D1 regulation is unrelated to IKKbeta/NF-kappaB activity...
  53. pmc Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia
    Yun Seon Song
    Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305 5487, USA
    J Cereb Blood Flow Metab 30:1265-74. 2010
    ..These results suggest that augmentation of NIK, IKKalpha, and pH3 in response to oxidative stress is involved in cell death after cerebral ischemia (or stroke)...
  54. pmc IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway
    Mazhar Adli
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e9428. 2010
    ..These conclusions have led to a focus on development of IKKbeta inhibitors for potential use in inflammatory disorders and cancer...
  55. doi Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells
    Katsuaki Hoshino
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan
    J Immunol 184:3341-5. 2010
    ..b>IkappaB kinase alpha (IKKalpha) is critically involved in this type I IFN production through its interaction with IFN regulatory ..
  56. pmc Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
    Marianna Penzo
    Vita Salute San Raffaele University, School of Medicine, San Raffaele Scientific Institute, Milano, Italy
    J Immunol 184:4497-509. 2010
    ..Thus, proinflammatory HMGB1 chemotactic responses mechanistically require the differential collaboration of both IKK-dependent NF-kappaB signaling pathways...
  57. pmc Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation
    Sangwoon Chung
    Dept of Environmental Medicine, Univ of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 299:L192-203. 2010
    ....
  58. pmc The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida, USA
    Nat Immunol 12:834-43. 2011
    ..IKKα therefore serves a key role in the negative feedback of NF-κB canonical signaling by orchestrating assembly of the A20 ubiquitin-editing complex to limit inflammatory gene activation...
  59. pmc NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation
    Hans Hacker
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 188:4602-10. 2012
    ....
  60. pmc IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis
    Mumtaz Yaseen Balkhi
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21701, USA
    Blood 119:5467-77. 2012
    ..The results of the present study demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis...
  61. pmc I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection
    Alessandra Mancino
    Centre d Immunologie de Marseille Luminy CIML, Aix Marseille Universite, UM2, Marseille, France
    EMBO J 32:816-28. 2013
    ..The serine/threonine kinase IKKα (CHUK) has previously been shown to have anti-inflammatory activity and inhibit innate immunity...
  62. pmc Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
    Ning Li
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, UCSD, La Jolla, California 92093 0723, USA
    J Clin Invest 123:2231-43. 2013
    ....
  63. pmc The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas
    Zuoxiang Xiao
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA
    Cancer Cell 23:527-40. 2013
    ..This mouse model resembles human lung SCCs, sheds light on the mechanisms underlying lung malignancy development, and identifies targets for therapy of lung SCCs...
  64. pmc Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase
    S Nemoto
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Cell Biol 18:7336-43. 1998
    ..The formation of the MEKK1-IKK complex versus the NIK-IKK complex may provide a molecular basis for regulation of the IKK complex by various extracellular signals...
  65. ncbi IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva
    K Yoshida
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, USA
    Invest Ophthalmol Vis Sci 41:3665-9. 2000
    To determine the requirement of IkappaB kinase alpha (Ikkalpha) for differentiation of the mammalian cornea and conjunctiva.
  66. ncbi Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha
    Michelle L Chaisson
    Department of Cancer Biology, Amgen Incorporated, Seattle, Washington 98119, USA
    J Biol Chem 279:54841-8. 2004
    ..Mice expressing a kinase-inactive form of the inhibitor of kappa B kinase alpha (IKK alpha) have mammary gland defects similar to those of RANK-null mice yet have apparently normal osteoclast function...
  67. pmc Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1)
    Qiutang Li
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:12425-30. 2005
    ..Because IKK1-/- mice died at birth, we differentiated functional macrophages from embryonic day 15.5 IKK1 mutant embryonic liver...
  68. ncbi IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing
    Feng Zhu
    Science Park Research Division, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Mol Cell 27:214-27. 2007
    ..IKKalpha mutants that failed to bind to H3 did not restore the expression of 14-3-3sigma. Thus, IKKalpha protects the 14-3-3sigma locus from hypermethylation, which serves as a mechanism of maintaining genomic stability in keratinocytes...
  69. pmc IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
    Pascal Descargues
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 105:2487-92. 2008
    Cell-cycle exit and differentiation of suprabasal epidermal keratinocytes require nuclear IkappaB kinase alpha (IKKalpha), but not its protein kinase activity...
  70. ncbi Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas
    Eunmi Park
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 67:9158-68. 2007
    We reported recently a marked reduction in IkappaB kinase alpha (IKKalpha) expression in a large proportion of human poorly differentiated squamous cell carcinomas (SCC) and the occurrence of Ikkalpha mutations in human SCCs...
  71. pmc IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin
    B Liu
    Department of Carcinogenesis, The University of Texas, MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cell Death Differ 18:1854-64. 2011
    ..Thus, IKKα maintains skin homeostasis through a broad range of signaling pathways...
  72. pmc The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1
    Richard R Kew
    Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    J Immunol 188:2380-6. 2012
    ..This novel requirement for a second receptor-ligand pair enhances our understanding of the molecular mechanisms regulating HMGB1-dependent cell recruitment to sites of tissue injury...
  73. pmc IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism
    Nadine Bakkar
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 196:497-511. 2012
    ..Together, these data provide insight on PGC-1β regulation during skeletal myogenesis and reveal a unique function of alternative NF-κB signaling in promoting an oxidative metabolic phenotype...
  74. ncbi Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern
    C Grimm
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Dev Genet 23:299-316. 1998
    ..0 +/- 3.5 cM proximal to ak and is excluded as a candidate gene. Sequence analysis of Fgf8 and Chuk1, which are localized close to the marker D19Mit10, detected no mutations in the ak/ak mutants...
  75. ncbi A mouse chromosome 19 genetic map including the Lvis1 viral insertion site
    G M Hansen
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Genomics 56:228-31. 1999
    ..In addition, our study refines the gene order for distal mouse chromosome 19 and expands the comparative map between mouse chromosome 19 and the human chromosome 10q23-q26 homology region...
  76. ncbi Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase
    D J Weaver
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 167:1461-8. 2001
    ..An enhanced capacity of NOD DCs to secrete IL-12 would be expected to contribute to the development of pathogenic Th1 (Tc1) cells during the diabetogenic response...
  77. ncbi I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function
    Hong Ren
    Division of Hematology Oncology, Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 168:3721-31. 2002
    ..These results suggest that IKKalpha and IKKbeta have distinct roles in regulating thymocyte function...
  78. ncbi Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation
    Ruxana T Sadikot
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 170:1091-8. 2003
    ..Therapies targeted to NF-kappaB in lung epithelium may be beneficial in treating inflammatory lung diseases...
  79. ncbi Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions
    Jonathan M Shillingford
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Histochem Cytochem 51:555-65. 2003
    ..We propose that the technique of proteotyping will have wide applications in the analyses of defects in other mouse models...
  80. pmc Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs
    Loukia Maria Mitsos
    Department of Biochemistry, Center for Host Resistance, and Cancer Center, McGill University, Montreal, PQ, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 100:6610-5. 2003
    ..These results suggest a strong genetic interaction between Trl-3 and Trl-4 in regulating pulmonary replication of M. tuberculosis...
  81. ncbi Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia
    Jose Luis Cascallana
    Department of Animal Pathology, Veterinary Faculty, University of Santiago de Compostela, E 27002 Lugo, Spain
    Endocrinology 146:2629-38. 2005
    ....
  82. ncbi Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance
    Dan Kinoshita
    Department of Obstetrics and Gynecology, Institute of Health Biosciences, University of Tokushima Graduate School, Japan
    J Immunol 176:3995-4002. 2006
    ..Thus, our results demonstrate a novel function for IKKalpha in thymic organogenesis for the establishment of central tolerance that depends on its protein kinase activity in cooperation with NIK...
  83. ncbi Use of Chuk as an internal standard suitable for quantitative RT-PCR in mouse preimplantation embryos
    Geppino Falco
    Developmental Genomics and Ageing Section, Laboratory of Genetics, National Institute on Ageing, National Institutes of Health, Baltimore, MD 21224, USA
    Reprod Biomed Online 13:394-403. 2006
    ..embryos, it was found that a conserved helix-loop-helix ubiquitous kinase gene (Chuk, also known as IkappaB kinase alpha, IKKalpha or IKK1) satisfied this criterion...
  84. ncbi A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae
    Unhwan Ha
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 178:1736-47. 2007
    ..pneumoniae...
  85. ncbi Epithelial NEMO links innate immunity to chronic intestinal inflammation
    Arianna Nenci
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Nature 446:557-61. 2007
    ..inhibition of NF-kappaB through conditional ablation of NEMO (also called IkappaB kinase-gamma (IKKgamma)) or both IKK1 (IKKalpha) and IKK2 (IKKbeta)-IKK subunits essential for NF-kappaB activation-spontaneously caused severe chronic ..
  86. ncbi Mouse models of psoriasis
    Johann E Gudjonsson
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 127:1292-308. 2007
    ..In this review, we describe various animal models, detail the immunologic and intracellular pathways that mediate these phenotypes and assess the utility of these models to better understand this disease...
  87. pmc IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells
    Yixue Cao
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 104:15852-7. 2007
    ..Ikkalpha(AA/AA) "knockin" mice in which activation of IkappaB kinase alpha (IKKalpha) is prevented by replacement of activation loop serines with alanines exhibit delayed mammary ..
  88. pmc Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness
    Cristen Pantano
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Respir Crit Care Med 177:959-69. 2008
    ..Previous studies demonstrated that inhibition of NF-kappaB in airway epithelium causes attenuation of allergic inflammation...
  89. pmc PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination
    Shitao Li
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 33:30-42. 2009
    ....
  90. doi Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction
    Konrad A Bode
    Department of Medical Microbiology and Hygiene, University of Heidelberg, Heidelberg, Germany
    J Immunol 182:2176-84. 2009
    ..It is suggested that differences in the kinetics of a common TLR signaling module affect the biological response patterns of various TLRs, with IL-12p40 being a gene that needs prolonged NF-kappaB activation...
  91. doi RIP4 regulates epidermal differentiation and cutaneous inflammation
    Ryan B Rountree
    Department of Oncology, Amgen, Seattle, Washington, USA
    J Invest Dermatol 130:102-12. 2010
    ..These data suggest that RIP4 functions in the epidermis through PKC-specific signaling pathways to regulate differentiation and inflammation...
  92. doi Increases in nuclear p65 activation in dystrophic skeletal muscle are secondary to increases in the cellular expression of p65 and are not solely produced by increases in IkappaB-alpha kinase activity
    Rajvir Singh
    Department of Physiology, Kirksville College of Osteopathic Medicine, AT Still University, Kirksville, MO 63501, USA
    J Neurol Sci 285:159-71. 2009
    ....
  93. doi Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression
    Hsiangling Teo
    Laboratory of NFkappaB Signaling, Proteos, Singapore 138673, Singapore
    Nat Cell Biol 12:758-67. 2010
    ..These results identify the first cytoplasmic role of Rap1 and provide a mechanism through which it regulates an important signalling cascade in mammals, independent of its ability to regulate telomere function...
  94. pmc A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity
    Laurent Leotoing
    INSERM, U1016, Institut Cochin, 75014 Paris, France
    J Biol Chem 286:32277-88. 2011
    ..These results imply that ABIN-2 acts as a positive regulator of NF-κB-dependent transcription by activating IKKα...
  95. ncbi IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes
    M C Hu
    Department of Cell Biology and Functional Genomics, Amgen, Inc, Thousand Oaks, CA 91320, USA
    Gene 222:31-40. 1998
    ..2. These results indicated that both genes are not clustered on the same chromosome; nevertheless, both genes may be still regulated similarly during development and in adult tissues...
  96. ncbi The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation
    Martine Dunnwald
    Department of Oral Biology, University of Washington, Seattle, WA, USA
    Exp Dermatol 12:245-54. 2003
    ..locus and consideration of the candidate genes: calpain 1 (Capn1), phospholipase C beta 3 (Plcb3), and Rela and Ikka/Chuk that encode components of the nuclear factor-kappa B (NF-kappaB) pathway...
  97. pmc ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage
    Ganesh R Panta
    Department of Pharmacology, Center for Anticancer Drug Research, University of Tennessee Cancer Institute, College of Medicine, Memphis, Tennessee 38163, USA
    Mol Cell Biol 24:1823-35. 2004
    ..Collectively, our findings suggest that distinct members of the phosphatidylinositol kinase family activate a common prosurvival MAPK/IKK/NF-kappaB pathway that opposes the apoptotic response following DNA damage...
  98. ncbi Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway
    Keishi Makino
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:3883-7. 2004
    ..expression of ILK-KD in HER2/neu-transformed cells suppressed Akt phosphorylation and the expression of IkappaB kinase alpha and beta (IKKalpha and beta) at both the protein and mRNA levels, preventing IkappaB-alpha degradation and ..
  99. ncbi IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    Mickey C T Hu
    Department of Molecular and Cellular Oncology, The University of Texas, Houston, TX 77030, USA
    Cell 117:225-37. 2004
    ..These results suggest the negative regulation of FOXO factors by IKK as a key mechanism for promoting cell growth and tumorigenesis...
  100. ncbi Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation
    Andreas Panopoulos
    Department of Molecular Microbiology and Immunology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine at USC, Los Angeles, California 90033, USA
    J Biol Chem 280:2912-23. 2005
    ..Cleavage and degradation of TNF pathway components TNFR1, RIP, and Hsp90 were observed in l-mimosine and H(2)O(2) treated cells indicating a putative mechanism for selective inhibition of TNF but not IL-1beta-induced IKK activation...
  101. ncbi Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Rd, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:9765-8. 2005
    ..physiological processing of p100 triggered by NF-kappaB-inducing kinase (NIK) and its downstream kinase, IkappaB kinase alpha (IKKalpha), which requires the E3 ligase, beta-transducin repeat-containing protein (beta-TrCP), and occurs ..

Research Grants3

  1. NF-kappaB: Biology and Pathology
    Sankar Ghosh; Fiscal Year: 2004
    ..Students will greatly benefit from exposure to many different biological processes, diseases and scientific approaches. ..
  2. Subversion of innate immune responses by Brucella
    Sankar Ghosh; Fiscal Year: 2006
    ..We are therefore proposing to characterize the role of TIRB in Brucella infection and we believe that our studies will help in the future development of therapeutic strategies, including vaccination, against human infection by Brucella. ..
  3. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
    ..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..