Chrnb2

Summary

Gene Symbol: Chrnb2
Description: cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
Alias: Acrb-2, Acrb2, C030030P04Rik, [b]2-nAchR, neuronal acetylcholine receptor subunit beta-2, acetylcholine receptor beta 2 neural
Species: mouse

Top Publications

  1. ncbi Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
    M R Picciotto
    CNRS UA D1284 Neurobiologie Moleculaire, Institut Pasteur, Paris, France
    Nature 374:65-7. 1995
  2. ncbi Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine
    M R Picciotto
    CNRS UA D1284, Neurobiologie moleculaire, Institut Pasteur, Paris, France
    Nature 391:173-7. 1998
  3. ncbi Identification of four classes of brain nicotinic receptors using beta2 mutant mice
    M Zoli
    Centre National de la Recherche Scientifique Unité de Recherche Associée D1284, Neurobiologie moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 18:4461-72. 1998
  4. pmc Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors
    M Zoli
    CNRS UA D1284, Neurobiologie moleculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 18:1235-44. 1999
  5. ncbi Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors
    W Xu
    Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Neurosci 19:9298-305. 1999
  6. ncbi Mice lacking specific nicotinic acetylcholine receptor subunits exhibit dramatically altered spontaneous activity patterns and reveal a limited role for retinal waves in forming ON and OFF circuits in the inner retina
    A Bansal
    Synapse Formation and Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, Maryland, USA
    J Neurosci 20:7672-81. 2000
  7. ncbi Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei
    R Klink
    Laboratoire de Neurobiologie Moléculaire, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182 Récepteurs et Cognition, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 21:1452-63. 2001
  8. pmc Requirement of the nicotinic acetylcholine receptor beta 2 subunit for the anatomical and functional development of the visual system
    F M Rossi
    Laboratoire de Neurobiologie Moléculaire, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Recepteurs et Cognition, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 98:6453-8. 2001
  9. ncbi Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1
    Ines Ibanez-Tallon
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, New York, NY 10021, USA
    Neuron 33:893-903. 2002
  10. ncbi Retinogeniculate axons undergo eye-specific segregation in the absence of eye-specific layers
    Gianna Muir-Robinson
    Neurobiology Section, Biology Division, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 22:5259-64. 2002

Research Grants

Scientific Experts

Detail Information

Publications108 found, 100 shown here

  1. ncbi Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
    M R Picciotto
    CNRS UA D1284 Neurobiologie Moleculaire, Institut Pasteur, Paris, France
    Nature 374:65-7. 1995
    ..Paradoxically, mutant mice are able to perform better than their non-mutant siblings on this task...
  2. ncbi Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine
    M R Picciotto
    CNRS UA D1284, Neurobiologie moleculaire, Institut Pasteur, Paris, France
    Nature 391:173-7. 1998
    ..Our results strongly support the idea that the beta2-containing neuronal nicotinic acetylcholine receptor is involved in mediating the reinforcing properties of nicotine...
  3. ncbi Identification of four classes of brain nicotinic receptors using beta2 mutant mice
    M Zoli
    Centre National de la Recherche Scientifique Unité de Recherche Associée D1284, Neurobiologie moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 18:4461-72. 1998
    ..Type 4 nAChRs also exhibit faster desensitization than type 3 nAChRs at high doses of nicotine. Knock-out animals lacking individual alpha subunits should allow a further dissection of nAChR subclasses...
  4. pmc Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors
    M Zoli
    CNRS UA D1284, Neurobiologie moleculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 18:1235-44. 1999
    ....
  5. ncbi Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors
    W Xu
    Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Neurosci 19:9298-305. 1999
    ..The phenotype of the beta2-/-beta4-/- and alpha3-/- mice resembles the autosomal recessive megacystis-microcolon-hypoperistalsis syndrome in humans...
  6. ncbi Mice lacking specific nicotinic acetylcholine receptor subunits exhibit dramatically altered spontaneous activity patterns and reveal a limited role for retinal waves in forming ON and OFF circuits in the inner retina
    A Bansal
    Synapse Formation and Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, Maryland, USA
    J Neurosci 20:7672-81. 2000
    ..These results indicate that retinal waves mediated by nAChRs are involved in, but not required for, the development of neural circuits that define the ON and OFF sublamina of the inner plexiform layer...
  7. ncbi Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei
    R Klink
    Laboratoire de Neurobiologie Moléculaire, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182 Récepteurs et Cognition, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 21:1452-63. 2001
    ..Neurons in the DA nuclei thus exhibit a diversity of nAChRs that might differentially modulate reinforcement and motor behavior...
  8. pmc Requirement of the nicotinic acetylcholine receptor beta 2 subunit for the anatomical and functional development of the visual system
    F M Rossi
    Laboratoire de Neurobiologie Moléculaire, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Recepteurs et Cognition, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 98:6453-8. 2001
    ..We conclude that the beta2 subunit of the nicotinic acetylcholine receptor is necessary for the anatomical and functional development of the visual system...
  9. ncbi Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1
    Ines Ibanez-Tallon
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, New York, NY 10021, USA
    Neuron 33:893-903. 2002
    ....
  10. ncbi Retinogeniculate axons undergo eye-specific segregation in the absence of eye-specific layers
    Gianna Muir-Robinson
    Neurobiology Section, Biology Division, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 22:5259-64. 2002
    ..These results indicate that spontaneous neural activity may independently regulate eye-specific segregation and the formation of layers at the developing retinothalamic projection...
  11. pmc beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure
    Gary Cohen
    Laboratoire de Neurologie et de Physiologie du Développement, Institut National de la Santé et de la Recherche Médicale E9935, Hopital Robert Debre, 75019 Paris, France
    Proc Natl Acad Sci U S A 99:13272-7. 2002
    ..We propose that nicotine impairs breathing (and possibly arousal) responses to stress by disrupting functions normally regulated by beta2-containing, high-affinity nAChRs...
  12. pmc Executive and social behaviors under nicotinic receptor regulation
    Sylvie Granon
    Department of Neuroscience, Receptors and Cognition Centre National de la Recherche Scientifique 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 100:9596-601. 2003
    ..Such deficits in executive functions resemble the rigid and asocial behavior found in some psychopathological disorders such as autism and attention deficit hyperactivity disorder...
  13. ncbi Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice
    Nicolas Champtiaux
    Laboratoire de Neurobiologie Moléculaire, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182 Récepteurs et Cognition, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 23:7820-9. 2003
    ....
  14. ncbi Retinotopic map refinement requires spontaneous retinal waves during a brief critical period of development
    Todd McLaughlin
    Molecular Neurobiology Lab, The Salk Institute, La Jolla, CA 92037, USA
    Neuron 40:1147-60. 2003
    ..Thus, spontaneous retinal waves that correlate RGC activity are required for retinotopic map remodeling during a brief early critical period...
  15. ncbi Beta2-containing nicotinic receptors contribute to the organization of sleep and regulate putative micro-arousals in mice
    Clément Léna
    Recepteurs et Cognition, Unité de Recherche Associée Centre National de la Recherche Scientifique, Institut Pasteur, 757242 Paris Cedex 15, France
    J Neurosci 24:5711-8. 2004
    ..Our results show that the beta2-containing nAChRs contribute to the organization of sleep by regulating the transient phasic activity in NREMS, the REMS onset and duration, and the REMS-promoting effect of stress...
  16. ncbi Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors
    L M Marubio
    Baylor College of Medicine, Department of Human and Molecular Genetics, One Baylor Plaza, Houston, TX 77030, USA
    Neuroscience 129:575-82. 2004
    ..Mice lacking both the alpha7 and the beta2 nAChR subunits displayed impaired learning and memory performance in a passive avoidance test and showed enhanced motor performance on the rotarod...
  17. pmc High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections
    Christine L Torborg
    Neurobiology Section, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0357, USA
    Nat Neurosci 8:72-8. 2005
    ..These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation...
  18. ncbi Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
    U Maskos
    Unité Récepteurs et Cognition, CNRS URA 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 436:103-7. 2005
    ..We thus demonstrate the sufficient role of the VTA in both nicotine reinforcement and endogenous cholinergic regulation of cognitive functions...
  19. ncbi Evidence for an instructive role of retinal activity in retinotopic map refinement in the superior colliculus of the mouse
    Anand R Chandrasekaran
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 25:6929-38. 2005
    ..These experiments demonstrate how axon guidance cues and activity-dependent factors combine to instruct retinotopic map development...
  20. ncbi The role of nicotinic acetylcholine receptors in lymphocyte development
    Marina Skok
    Department of Molecular Immunology, Palladin Institute of Biochemistry, 01601 Kiev, Ukraine
    J Neuroimmunol 171:86-98. 2006
    ..More annexin V-positive B cells were found in the bone marrow of knockout than wild-type animals. We conclude that nicotinic receptors are involved in regulating lymphocyte development and control the B lymphocyte survival...
  21. pmc Development of precise maps in visual cortex requires patterned spontaneous activity in the retina
    Jianhua Cang
    W M Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 48:797-809. 2005
    ..Our findings demonstrate that disrupting early spontaneous activity in the eye alters thalamic connections to the cortex...
  22. ncbi Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors
    Monica Mameli-Engvall
    CNRS URA 2182 Unité Récepteurs et Cognition, Institut Pasteur, 75724 Paris Cedex 15, France
    Neuron 50:911-21. 2006
    ....
  23. pmc Ephrin-As and patterned retinal activity act together in the development of topographic maps in the primary visual system
    Cory Pfeiffenberger
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
    J Neurosci 26:12873-84. 2006
    ....
  24. pmc Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 89:106-13. 2008
    ..In addition, nicotine withdrawal selectively affects acquisition but not recall or expression of the learned response...
  25. ncbi Nicotinic acetylcholine receptors alpha4beta2 and alpha7 regulate myelo- and erythropoiesis within the bone marrow
    Lyudmyla M Koval
    Palladin Institute of Biochemistry, 9 Leontovicha Str, 10601 Kyiv, Ukraine
    Int J Biochem Cell Biol 40:980-90. 2008
    ....
  26. doi Retinocollicular synapse maturation and plasticity are regulated by correlated retinal waves
    Ruchir D Shah
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 28:292-303. 2008
    ....
  27. pmc Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice
    Barbara J Caldarone
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Neurosci Lett 439:187-91. 2008
    ..This shows that female mice have an anxiogenic-like response to chronic nicotine, but are less sensitive to nicotine's psychostimulant properties, which may be related to the increased relapse to smoking following abstinence in women...
  28. doi Chronic nicotine exposure has dissociable behavioural effects on control and beta2-/- mice
    Morgane Besson
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Department of Neuroscience and CNRS URA2182, Institut Pasteur, 25 rue du Dr Roux, Paris 75015, France
    Behav Genet 38:503-14. 2008
    ..These data support the proposal that beta2-/- mice represent a relevant model for cognitive disorders in humans and that nicotine administered chronically at low dose may relieve some of these...
  29. doi Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells
    Andrew D Huberman
    Department of Neurobiology, Fairchild Science Building D235, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Neuron 59:425-38. 2008
    ..Our findings reveal that in a genetically identified sensory map, spontaneous activity promotes synaptic specificity by segregating axons arising from RGCs of the same subtype...
  30. pmc Retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor
    Chao Sun
    Departments of Neurobiology, Physiology, and Behavior, and Ophthalmology and Vision Science, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 105:13638-43. 2008
    ....
  31. pmc Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion
    Maria Elena Avale
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Unité de Recherche Associée 2182, Centre National de la Recherche Scientifique, Institut Pasteur, F75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 105:15991-6. 2008
    ..These findings highlight the crucial interplay of nAChRs over the DA control of spontaneous locomotion...
  32. pmc Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration
    Nicolas Maubourguet
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, Paris, France
    PLoS Comput Biol 4:e1000229. 2008
    ....
  33. doi Expression of mutant beta2 nicotinic receptors during development is crucial for epileptogenesis
    Irene Manfredi
    San Raffaele Scientific Institute, Milan, Italy
    Hum Mol Genet 18:1075-88. 2009
    ..Our data indicate that mutant nicotinic receptors are responsible for abnormal formation of neuronal circuits and/or long-lasting alteration of network assembly in the developing brain, thus leading to epilepsy...
  34. pmc A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides
    Qiang Liu
    Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    J Neurosci 29:918-29. 2009
    ....
  35. pmc Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80301, USA
    J Neurosci 29:2272-82. 2009
    ....
  36. pmc Spatial-temporal patterns of retinal waves underlying activity-dependent refinement of retinofugal projections
    Ben K Stafford
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Neuron 64:200-12. 2009
    ..Quantitative analysis suggests that wave directionality, coupled with short-range correlated bursting patterns of RGCs, work together to refine retinofugal projections...
  37. pmc Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes
    Reinhard David
    Department of Biochemistry and Molecular Biology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Eur J Neurosci 31:978-93. 2010
    ..Our data, based on biochemical and functional experiments and several mouse KO models, clarify and significantly extend previous observations on the function of nAChRs in heterologous systems and the SCG...
  38. pmc Development of single retinofugal axon arbors in normal and β2 knock-out mice
    Onkar S Dhande
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 31:3384-99. 2011
    ..In β2(-/-) mice, we found that retinofugal single axon arbors are well ramified but enlarged, particularly in the SC, indicating that activity-dependent visual map development occurs through the refinement of individual RGC arbors...
  39. doi Prefrontal nicotinic receptors control novel social interaction between mice
    Maria Elena Avale
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, CNRS URA 2182, Institut Pasteur, Paris, France
    FASEB J 25:2145-55. 2011
    ..Together, these data reveal that social interactions particularly mobilize the PrL area of the mouse PFC and that the presence of functional PrL β2*-nAChRs is necessary for this integrated behavior to emerge...
  40. pmc An instructive role for patterned spontaneous retinal activity in mouse visual map development
    Hong Ping Xu
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 70:1115-27. 2011
    ..This suggests that specific patterns of spontaneous activity throughout the developing brain are essential in the emergence of specific and distinct patterns of neuronal connectivity...
  41. doi Beta2-containing neuronal nicotinic receptors as major actors in the flexible choice between conflicting motivations
    P Serreau
    Neurobiologie intégrative des systèmes cholinergiques, Département Neurosciences, Institut Pasteur and CNRS URA 2182, 25 rue du Docteur Roux, 75015 Paris, France
    Behav Brain Res 225:151-9. 2011
    ..Indeed, the ability to show flexible behaviours and to display adapted social interactions is profoundly impaired in a myriad of psychiatric disorders...
  42. doi Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment
    Jean Pierre Bourgeois
    Unité de Génétique Humaine et Fonctions Cognitives, Departement des Neurosciences, Institut Pasteur, 75015 Paris, France
    Cereb Cortex 22:1007-15. 2012
    ..We also highlight the role of nicotinic receptors during activation of the PFC, specifically during free exploration of a novel environment...
  43. doi Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention
    Karine Guillem
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, Netherlands
    Science 333:888-91. 2011
    ..Our findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance...
  44. pmc Subunit composition of α5-containing nicotinic receptors in the rodent habenula
    Petra Scholze
    Center for Brain Research, Medical University of Vienna, Vienna, Austria
    J Neurochem 121:551-60. 2012
    ..Observations in β2 and β4 null mice indicate that although α5 requires the presence of the β4 subunit for assembling (but not of β2), α5 in wild-type mice assembles into receptors that also contain the subunits α3, β2, and β4...
  45. ncbi Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit
    Ramiro Salas
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:10035-9. 2004
    ..We also show that the upregulation of epibatidine binding sites attributable to chronic nicotine, an effect associated with beta2-containing receptors, is probably not related to the mechanisms underlying withdrawal...
  46. ncbi Abnormal functional organization in the dorsal lateral geniculate nucleus of mice lacking the beta 2 subunit of the nicotinic acetylcholine receptor
    Matthew S Grubb
    University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, United Kingdom
    Neuron 40:1161-72. 2003
    ..The presence of the beta2 subunit of the nAChR in the CNS is therefore important for normal functional organization in the retinogeniculate projection...
  47. pmc Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs
    K J Jackson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 325:302-12. 2008
    ....
  48. pmc Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 196:207-13. 2009
    ....
  49. pmc Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor
    J Xu
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Psychiatry 16:1048-61. 2011
    ..Together, these findings emphasize several important roles of β2* nicotinic receptors in complex biological processes including the activity-rest cycle, natural reward and anxiety...
  50. doi Dynamic alterations of gene expression of nicotinic acetylcholine receptor α7, α4 and β2 subunits in an acute MPTP-lesioned mouse model
    Jun Hu
    Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Guang Zhou Road 300, Nanjing 210029, China
    Neurosci Lett 494:232-6. 2011
    ..These data suggest that therapeutic strategies targeted toward nAChR α7, α4 and β2 subunits may have potential for developing new treatments for PD...
  51. pmc Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion
    Nicole K Horst
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Behav Brain Res 231:170-80. 2012
    ..This suggests that the auditory discrimination impairments are not a consequence of a general deficit in learning and memory, but may be the result of compromised auditory stimulus processing in the nicotine-exposed and knockout animals...
  52. pmc Induction of dendritic spines by β2-containing nicotinic receptors
    Adrian F Lozada
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 32:8391-400. 2012
    ..Because spine synapses differ from shaft synapses in their signaling capabilities, the shift observed is likely to have significant consequences for network function...
  53. pmc γ-Aminobutyric acid type A receptor inhibition triggers a nicotinic neuroprotective mechanism
    P A Ferchmin
    School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 91:416-25. 2013
    ..These results shed light on how α7 nAChR inhibition can be neuroprotective through a mechanism mediated by activation of α4β2 nAChRs...
  54. doi Working memory deficits and related disinhibition of the cAMP/PKA/CREB are alleviated by prefrontal α4β2*-nAChRs stimulation in aged mice
    Matthias Vandesquille
    CNRS, Univ Bordeaux, INCIA UMR 5287, Bordeaux, France
    Neurobiol Aging 34:1599-609. 2013
    ..Thus, by targeting the α4β2*-nicotinic receptor of the PL, S 38232 alleviates PL CREB overphosphorylation and restores WM in aged mice, which opens new pharmacologic perspectives of therapeutic strategy...
  55. pmc Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain
    G Patrick Hussmann
    Department of Pharmacology and Physiology, Georgetown University School of Medicine, Washington, District of Columbia, USA
    J Neurochem 129:721-31. 2014
    ..These findings suggest that apart from its modest anxiolytic and weight control effects, saz-A, or drugs like it, may be useful in achieving long-term abstinence from smoking...
  56. doi Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits
    Bruno Golding
    Department of Basic Neurosciences, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Neuron 81:1057-69. 2014
    ..These findings identify an input-dependent mechanism regulating IN migration and circuit inhibition, which may account for the progressive recruitment of INs into expanding excitatory circuits during evolution. ..
  57. doi Synaptic pattern of nicotinic acetylcholine receptor α7 and β2 subunits on the direction-selective retinal ganglion cells in the postnatal mouse retina
    Hyun Jin Kim
    Department of Biology, School of Life Sciences, KNU Creative BioResearch Group BK21 Plus Program, College of Natural Sciences, and Brain Science and Engineering Institute, Kyungpook National University, Daegu 702 701, South Korea Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungpook 790 784, South Korea
    Exp Eye Res 122:54-64. 2014
    ..Our results therefore provide anatomical and developmental evidence suggesting that the nAChR α7 and β2 subunits may involve in the early direction-selectivity formation of DS RGCs in the mouse retina. ..
  58. pmc Competition is a driving force in topographic mapping
    Jason W Triplett
    Department of Molecular, Cell, and Developmental Biology, Santa Cruz Institute of Particle Physics, University of California, Santa Cruz, CA 95064, USA
    Proc Natl Acad Sci U S A 108:19060-5. 2011
    ..Finally, we present a mathematical model for topographic mapping that incorporates molecular labels, neural activity, and axon competition...
  59. ncbi Modulation of nicotine but not ethanol preference by the mouse Chrna4 A529T polymorphism
    Christopher M Butt
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Behav Neurosci 119:26-37. 2005
    ..The results obtained by the authors indicate that the polymorphism in Chrna4 plays an important role in modulating variability in oral nicotine intake but is linked to a gene that regulates alcohol intake...
  60. doi Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors
    P S Huang
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    Neuroscience 196:189-202. 2011
    ..However, loss of β2* nAChRs could result in augmented cellular stress, which indirectly increases expression of SIRT1, Nampt, and Ku70 as an adaptive response to provide protection against neurodegeneration...
  61. pmc Role of adenylate cyclase 1 in retinofugal map development
    Onkar S Dhande
    Department of Neurobiology, Yale University, New Haven, Connecticut 06510, USA
    J Comp Neurol 520:1562-83. 2012
    ..These results suggest that AC1 in RGC axons mediates the development of retinotopy and eye-specific segregation in the SC and dorsal LGN...
  62. pmc Visual map development depends on the temporal pattern of binocular activity in mice
    Jiayi Zhang
    Department of Neurobiology, Yale University, New Haven, Connecticut, USA
    Nat Neurosci 15:298-307. 2011
    ....
  63. pmc Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer
    Junwei Hao
    Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
    PLoS ONE 8:e57495. 2013
    ..Our findings suggest nAChR β2 as a prominent pathway for nicotine induced impairment of NK cell functions which contributes to the occurrence of smoking-related pathologies...
  64. ncbi Distribution of neuronal nicotinic acetylcholine receptor gene restriction fragment length polymorphisms in inbred and partially inbred mice
    U Nagavarapu
    Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210, USA
    Pharmacogenetics 5:326-31. 1995
  65. ncbi Promoter elements conferring neuron-specific expression of the beta 2-subunit of the neuronal nicotinic acetylcholine receptor studied in vitro and in transgenic mice
    A Bessis
    UA CNRS D1284, Departement des Biotechnologies, Institut Pasteur 25 28, Paris, France
    Neuroscience 69:807-19. 1995
    ..In this paper, we describe the neuron-specific promoter of the gene encoding the neuronal nicotinic acetylcholine receptor beta 2-subunit...
  66. ncbi Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse
    D G Drescher
    Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 112:267-73. 1995
    ..The presence of messages corresponding to the muscle-type beta 1 and neuronal-type nAChR subunits may be correlated with the atypical cholinergic response of cochlear hair cells to agonists and antagonists...
  67. ncbi Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions
    B F O'Hara
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Brain Res Mol Brain Res 66:71-82. 1999
    ..In particular, a small 1.4 kb alpha2-related mRNA is highly expressed during early development, perhaps indicating an important novel function for this subunit...
  68. ncbi Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
    L M Marubio
    CNRS UA D1284 Neurobiologie Moleculaire, Institut Pasteur, Paris, France
    Nature 398:805-10. 1999
    ..The alpha4 nAChR subunit, possibly associated with the beta2 nAChR subunit, is therefore crucial for nicotine-elicited antinociception...
  69. pmc Tonic nicotinic modulation of serotoninergic transmission in the spinal cord
    M Cordero-Erausquin
    Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Recepteurs et Cognition, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 98:2803-7. 2001
    ..In addition, the presence of a tonic nicotinic modulation of 5-HT release indicates that endogenous acetylcholine plays a role in the physiological regulation of descending 5-HT pathways to the spinal cord...
  70. ncbi The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversion
    M Shoaib
    Section of Behavioural Pharmacology, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Neuropharmacology 42:530-9. 2002
    ..Such receptors appear to have a less crucial role in the response-rate, reducing effects of nicotine and in nicotine tolerance...
  71. ncbi Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus
    Yen Kuo
    Division of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, 85013, Phoenix, AZ, USA
    J Neuroimmunol 130:140-54. 2002
    ..These studies suggest important roles for nAChR in immune system development and function and in the neuroimmune network...
  72. ncbi Control of breathing in newborn mice lacking the beta-2 nAChR subunit
    S Dauger
    Laboratoire de Neurologie et Physiologie du Développement, INSERM E9935, Hopital Robert Debre, boulevard Serurier, Paris, France
    Acta Physiol Scand 182:205-12. 2004
    ..To study the ventilatory and arousal/defence responses to hypoxia in newborn mutant mice lacking the beta2 subunit of the nicotinic acetylcholine receptors...
  73. ncbi Visual response properties in the dorsal lateral geniculate nucleus of mice lacking the beta2 subunit of the nicotinic acetylcholine receptor
    Matthew S Grubb
    University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
    J Neurosci 24:8459-69. 2004
    ....
  74. ncbi Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration
    Sarah L King
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Neuropharmacology 47:132-9. 2004
    ....
  75. ncbi Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning
    J M Wehner
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309 0447, USA
    Neuroscience 129:11-24. 2004
    ..A new role for alpha7 nAChRs in regulating sensitivity to the cognitive disrupting effects of ethanol is proposed...
  76. ncbi Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells
    Mark S Karadsheh
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Neurochem 91:1138-50. 2004
    ..Consequently, at low nanomolar concentrations, MLA may not be as selective for alpha7-containing nAchRs as previously thought...
  77. pmc Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function
    Gary Cohen
    Karolinska Institute, Neonatal Unit, Astrid Lindgren Children s Hospital, S 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:3817-21. 2005
    ..We propose that the underlying mechanisms of nicotine's detrimental side effects on a range of crucial defensive reflexes involve loss of function of nAChR subtypes, possibly via activity-dependent desensitization...
  78. ncbi Up-regulation of beta2 and alpha7 subunit containing nicotinic acetylcholine receptors in mouse striatum at cellular level
    Jukka S Pakkanen
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, P O Box 56, FIN 00014 Finland
    Eur J Neurosci 21:2681-91. 2005
    ..This suggests that the trafficking of nAChR subunits is increased as a result of chronic nicotine treatment and nAChRs in all parts of neurons could have functional roles in the formation of nicotine addiction...
  79. ncbi Altered map of visual space in the superior colliculus of mice lacking early retinal waves
    Thomas D Mrsic-Flogel
    Max Planck Institut fur Neurobiologie, D 82152 Martinsried, Germany
    J Neurosci 25:6921-8. 2005
    ..Thus, patterned neuronal activity in the early retina has a substantial influence on the coarse retinotopic organization of the SC...
  80. ncbi Irreversible blockade of monoamine oxidases reveals the critical role of 5-HT transmission in locomotor response induced by nicotine in mice
    Anne Sophie Villegier
    INSERM U 114, College de France, 11, place Marcelin Berthelot, 75231 Paris Cedex 05, France
    Eur J Neurosci 24:1359-65. 2006
    ..Our data suggest that mixed irreversible MAOIs contained in tobacco facilitate the effects of nicotine on serotonin release, thus allowing the locomotor and rewarding effects of nicotine...
  81. ncbi The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice
    R L Rabenstein
    Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 189:395-401. 2006
    ..We therefore examined the effect of decreasing nicotinic acetylcholine receptor (nAChR) activity in tests of antidepressant efficacy using C57BL/6J mice...
  82. ncbi Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors
    B E Molles
    Unité Récepteurs et Cognition, Institut Pasteur, 75724 Paris Cedex 15, France
    J Mol Neurosci 30:105-6. 2006
    ..This latter behavioral analysis suggests a role for beta2* nAChR, specifically expressed in the VTA, in mammalian cognitive function...
  83. ncbi Developmental homeostasis of mouse retinocollicular synapses
    Anand R Chandrasekaran
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:1746-55. 2007
    ..Our results suggest that during the development of sensory maps, a unique consequence of homeostatic mechanisms is the precise shaping of neuronal receptive fields in conjunction with activity-dependent competition...
  84. pmc Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation
    P Scholze
    Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Br J Pharmacol 151:414-22. 2007
    ..We have now used brain slices to investigate nicotine-induced catecholamine outflow in wild type (WT) and nAChR (beta2 and alpha5) knockout mice for a comparison with rat brain slice preparations...
  85. pmc Chronic nicotine alters nicotinic receptor-induced presynaptic Ca2+ responses in isolated nerve terminals
    John J Dougherty
    Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
    Neurochem Res 33:1106-12. 2008
    ..These findings suggest that chronic exposure to nicotine may lead to enhanced sensitivity to nicotine at select presynaptic sites in brain via up-regulation of high-affinity nicotinic receptors...
  86. pmc Selective disruption of one Cartesian axis of cortical maps and receptive fields by deficiency in ephrin-As and structured activity
    Jianhua Cang
    W M Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 0444, USA
    Neuron 57:511-23. 2008
    ..Despite the dramatic disruption of azimuthal topography, the dorsoventral (elevation) map was relatively normal, indicating that the two axes of the cortical map are organized by separate mechanisms...
  87. pmc Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration
    S Pons
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 28:12318-27. 2008
    ....
  88. pmc Acetylcholine-stimulated [3H]GABA release from mouse brain synaptosomes is modulated by alpha4beta2 and alpha4alpha5beta2 nicotinic receptor subtypes
    Tristan D McClure-Begley
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Mol Pharmacol 75:918-26. 2009
    ....
  89. pmc Nicotine withdrawal-induced deficits in trace fear conditioning in C57BL/6 mice--a role for high-affinity beta2 subunit-containing nicotinic acetylcholine receptors
    J D Raybuck
    Center for Substance Abuse Research and Department of Psychology, 1701n 13th, Weiss Hall, 657, Temple University, Philadelphia, PA 19122, USA
    Eur J Neurosci 29:377-87. 2009
    ....
  90. pmc Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain
    Michael J Marks
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, United States
    Biochem Pharmacol 78:795-802. 2009
    ..As one form of alpha6beta2* nAChR is sensitive to sub-muM concentrations, we propose that this receptor in particular may contribute to the enhanced cognitive performance following low doses of ABT-089...
  91. pmc Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses
    Yi Fan Li
    Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA
    Neurosci Lett 462:20-3. 2009
    ..These data suggest that specific subtypes of nicotinic receptors at the level of the ganglia may play distinct roles in mediating sympathetic or parasympathetic activation...
  92. pmc Retinal input instructs alignment of visual topographic maps
    Jason W Triplett
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Cell 139:175-85. 2009
    ..These data suggest a general model in which convergent maps use coincident activity patterns to achieve alignment...
  93. pmc Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity
    William B Barkis
    Department of Molecular and Cell Biology and the Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 107:22302-7. 2010
    ..Thus, a diffusible signal that acts independent of local circuit activity regulates the maturation of GABAergic inhibition in mouse RGCs...
  94. pmc Old mice lacking high-affinity nicotine receptors resist acoustic trauma
    Haiyan Shen
    Model Animal Research Center of Nanjing University, 12 Xue Fu Road, Nanjing 210061, PR China
    Hear Res 277:184-91. 2011
    ....
  95. pmc Mouse mutants for the nicotinic acetylcholine receptor ß2 subunit display changes in cell adhesion and neurodegeneration response genes
    Carol M Rubin
    Department of Neurobiology, Physiology, and Behavior, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e18626. 2011
    Mice lacking expression of the ß2 subunit of the neuronal nicotinic acetylcholine receptor (CHRNB2) display abnormal retinal waves and a dispersed projection of retinal ganglion cell (RGC) axons to their dorsal lateral geniculate nuclei (..
  96. pmc Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotine
    CHRISTOPHER I RICHARDS
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 286:31241-9. 2011
    ..Superecliptic phluorin provides a tool to monitor trafficking dynamics of nAChRs in disease and addiction...
  97. ncbi Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes
    K K Lueders
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 10:900-5. 1999
    ..Using a 6-Mb YAC contig of Chr 1, we mapped the human beta2-nAChR gene, CHRNB2, to 1q21.3 with the order of markers cen, FLG, IVL, LOR, CHRNB2, tel...
  98. ncbi Nicotinic acetylcholine receptors in the autonomic control of bladder function
    M De Biasi
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Eur J Pharmacol 393:137-40. 2000
    ..These findings suggest that nicotinic receptors containing the alpha(3) and the beta(4) subunits are necessary for normal bladder function...
  99. pmc Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb
    Naguib Mechawar
    Receptors and Cognition Unit, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 101:9822-6. 2004
    ..They also indicate that an increase in the number of granule cells does not necessarily correlate with better olfactory performance and further highlight the importance of cholinergic afferents for olfactory processing...
  100. ncbi Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor
    Alexia Harrist
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Synapse 54:200-6. 2004
    ....
  101. ncbi Biochemical and anatomical subdivision of the dorsal lateral geniculate nucleus in normal mice and in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor
    Matthew S Grubb
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Vision Res 44:3365-76. 2004
    ....

Research Grants4

  1. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  2. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  3. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  4. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..