Chrna7

Summary

Gene Symbol: Chrna7
Description: cholinergic receptor, nicotinic, alpha polypeptide 7
Alias: Acra7, alpha7, nAchR, neuronal acetylcholine receptor subunit alpha-7, acetylcholine receptor alpha 7 neural, alpha7 nicotinic receptor, alpha7-nAChR
Species: mouse

Top Publications

  1. ncbi Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries
    Vincent Laudenbach
    Laboratoire de Neurologie du Développement, INSERM E9935, Hopital Robert Debre, Paris, France
    FASEB J 16:423-5. 2002
  2. ncbi Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes
    Alex I Chernyavsky
    Department of Dermatology, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
    J Cell Sci 117:5665-79. 2004
  3. ncbi Tolerance to nicotine in mice lacking alpha7 nicotinic receptors
    C Naylor
    Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, London, SE5 8AF, UK
    Psychopharmacology (Berl) 180:558-63. 2005
  4. ncbi Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
    Jason J Keller
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Behav Brain Res 162:143-52. 2005
  5. ncbi Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory
    C Fernandes
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 5:433-40. 2006
  6. ncbi Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
  7. doi Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus
    Mateo Vélez-Fort
    INSERM, U603, Paris, France
    Glia 57:1104-14. 2009
  8. doi Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro
    Da Wei Wang
    Emergency Department, General Hospital of Beijing Military Area Command, Beijing, People s Republic of China
    J Pharmacol Exp Ther 335:553-61. 2010
  9. pmc Trace eyeblink conditioning is impaired in α7 but not in β2 nicotinic acetylcholine receptor knockout mice
    Kevin L Brown
    Neuroscience Program and Department of Psychology, Temple University Philadelphia, PA, USA
    Front Behav Neurosci 4:166. 2010
  10. pmc Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice
    J W Young
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Genes Brain Behav 10:720-33. 2011

Research Grants

  1. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2005
  2. Cholinergic Modulation of Inflammatory CNS Cytokines
    LORISE GAHRING; Fiscal Year: 2006
  3. Nicotine Modulation of Caspases in Non-Neuronal Cells
    LORISE GAHRING; Fiscal Year: 2006
  4. CENTER FOR NEUROSCIENCE EXCELLENCE
    Rodney L Parsons; Fiscal Year: 2010
  5. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
  6. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
  7. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
  8. Nicotinic Receptors in Parkinson's Disease
    Maryka Quik; Fiscal Year: 2007
  9. Nicotinic and neuroprotection in a parkinson mouse model
    Maryka Quik; Fiscal Year: 2007
  10. ESCHERICHIA COLI INVASION OF BRAIN ENDOTHELIAL CELLS
    Sheng He Huang; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. ncbi Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries
    Vincent Laudenbach
    Laboratoire de Neurologie du Développement, INSERM E9935, Hopital Robert Debre, Paris, France
    FASEB J 16:423-5. 2002
    ..In contrast, activation of alpha7 nAChR, which is protective in adult animals, was deleterious in our neonatal model, whereas its blockade, either ..
  2. ncbi Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes
    Alex I Chernyavsky
    Department of Dermatology, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
    J Cell Sci 117:5665-79. 2004
    ..chemotaxis of keratinocytes was most pronounced towards the concentration gradient of choline, a potent agonist of alpha7 nicotinic acetylcholine receptor. The alpha7-preferring antagonist alpha-bungarotoxin significantly (P<0...
  3. ncbi Tolerance to nicotine in mice lacking alpha7 nicotinic receptors
    C Naylor
    Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, London, SE5 8AF, UK
    Psychopharmacology (Berl) 180:558-63. 2005
    Previous studies have suggested that a knockout of the gene coding for alpha7 nicotinic receptor subunits influences the behaviour of undrugged mice but not the acute effect of nicotine on locomotor activity.
  4. ncbi Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
    Jason J Keller
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Behav Brain Res 162:143-52. 2005
    ..These results support a role of the alpha7 nicotinic receptor in mediating appetitive learning and suggest a potential role for the alpha7 nAChRs in the regulation of ..
  5. ncbi Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory
    C Fernandes
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 5:433-40. 2006
    ..and animal studies suggest a role for the neural nicotinic acid receptor family in cognition and specifically the alpha7-receptor subunit in schizophrenia and its endophenotypes...
  6. ncbi Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
    ..These findings provide two robust and rapid assays for beta-amyloid-associated effects that can be performed on young animals: impaired contextual fear learning and up-regulation of alpha 7 nicotinic receptors...
  7. doi Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus
    Mateo Vélez-Fort
    INSERM, U603, Paris, France
    Glia 57:1104-14. 2009
    ..nanomolar concentrations of nicotine, which did not induce any response in these cells, largely desensitized nAChR-mediated currents...
  8. doi Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro
    Da Wei Wang
    Emergency Department, General Hospital of Beijing Military Area Command, Beijing, People s Republic of China
    J Pharmacol Exp Ther 335:553-61. 2010
    7 Nicotinic acetylcholine receptor (α7 nAChR) has been found in several non-neuronal cells and is described as an important regulator of cellular function...
  9. pmc Trace eyeblink conditioning is impaired in α7 but not in β2 nicotinic acetylcholine receptor knockout mice
    Kevin L Brown
    Neuroscience Program and Department of Psychology, Temple University Philadelphia, PA, USA
    Front Behav Neurosci 4:166. 2010
    ..The present study used genetically modified mice to investigate the effects of selective nAChR subunit deletion on delay and trace eyeblink classical conditioning...
  10. pmc Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice
    J W Young
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Genes Brain Behav 10:720-33. 2011
    The α7-nicotinic acetylcholine receptor (nAChR) has long been a procognitive therapeutic target to treat schizophrenia...
  11. pmc Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder
    Leomar Y Ballester
    Department of Biology, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico
    J Biol Chem 287:3079-86. 2012
    ..We studied the effects of gp120(IIIB) on the expression and function of the nicotinic receptor α7 (α7-nAChR)...
  12. doi Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, California, USA
    Am J Pathol 181:478-86. 2012
    ..7 Nicotinic acetylcholine receptor (α-7 nAchR) has been shown to be necessary for the vagus nerve to modulate the systemic inflammatory response, but the role ..
  13. pmc Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors
    Greg J Norman
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 31:3446-52. 2011
    ..Furthermore, we provide evidence that pharmacological activation of α7 nicotinic acetylcholine receptors provide significant protection against ischemia-related cell death and inflammation within a clinically relevant time frame...
  14. pmc Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors
    Adrian F Lozada
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0357, USA
    J Neurosci 32:7651-61. 2012
    ..dependence on α7-nAChRs becomes clear when comparing wild-type (WT) mice with mice constitutively lacking the α7-nAChR gene...
  15. doi α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice
    M Hijioka
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Chuo Ku, Kumamoto 862 0973, Japan
    Neuroscience 222:10-9. 2012
    ..Daily intraperitoneal injection of α7 nAChR agonist PNU-282987 (3-10mg/kg) for 3 days, starting from 3h after induction of ICH, significantly increased the ..
  16. doi Macrophages from alpha 7 nicotinic acetylcholine receptor knockout mice demonstrate increased cholesterol accumulation and decreased cellular paraoxonase expression: a possible link between the nervous system and atherosclerosis development
    Kenneth R Wilund
    Department of Kinesiology and Community Health, University of Illinois, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 390:148-54. 2009
    ..Mice deficient in the alpha 7 nicotinic acetylcholine receptor (alpha7(-/-)) have an impaired CAIR due to decreased signaling through this pathway...
  17. doi Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia
    Najla Taslim
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Behav Brain Res 217:282-92. 2011
    We have demonstrated that nicotine attenuated ethanol-induced ataxia via nicotinic-acetylcholine-receptor (nAChR) subtypes α(4)β(2) and α(7). In the present study, ethanol (2g/kg; i.p...
  18. pmc α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex
    Peder S Olofsson
    The Feinstein Institute for Medical Research, Laboratory of Biomedical Science, Manhasset, New York 11030, USA
    Mol Med 18:539-43. 2012
    ..Together, these results indicate that α7nAChR expression in bone marrow-derived non-T cells is required for the integrity of the inflammatory reflex...
  19. pmc Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression
    Jennifer L Hellier
    Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Brain Res 1358:140-50. 2010
    ..These data suggest that α7-nicotinic-receptors contribute strongly to olfactory discrimination and detection in mice and may be one of the mechanisms producing olfactory dysfunction in schizophrenics...
  20. ncbi NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor
    Leonard Moise
    Department of Molecular Pharmacology, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 277:12406-17. 2002
    ..alpha-bungarotoxin and a recombinantly expressed 19-mer peptide ((178)IPGKRTESFYECCKEPYPD(196)) derived from the alpha7 subunit of the chick neuronal nicotinic acetylcholine receptor...
  21. pmc Presynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axons
    Melissa L Hancock
    Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, New York, NY 10032, USA
    J Cell Biol 181:511-21. 2008
    ..We demonstrate that Type III Nrg1 back signaling regulates the surface expression of alpha7 nAChRs along axons of sensory neurons...
  22. pmc Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease
    Gustavo Dziewczapolski
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 29:8805-15. 2009
    ..recently shown that the Alzheimer's disease (AD) pathogenic peptide amyloid beta(1-42) (Abeta(1-42)) binds to the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) with high affinity and the alpha7nAChR and Abeta(1-42) are both ..
  23. ncbi Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents
    A Orr-Urtreger
    Department of Molecular and Human Genetics, Houston, Texas 77030, USA
    J Neurosci 17:9165-71. 1997
    The alpha7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is abundantly expressed in hippocampus and is implicated in modulating neurotransmitter release and in binding alpha-bungarotoxin (alpha-BGT)...
  24. pmc Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice
    R Paylor
    Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Learn Mem 5:302-16. 1998
    ..There is also evidence for an association between levels of alpha7 nAChR and in sensorimotor gating impairments...
  25. ncbi Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth
    A Orr-Urtreger
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 74:2154-66. 2000
    ..A threonine for leucine 247 substitution in the channel domain of the chick alpha7 nAChR increases agonist affinity and decreases the rate of desensitization, creating a "gain of function" model for ..
  26. ncbi Altered baroreflex responses in alpha7 deficient mice
    D Franceschini
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 113:3-10. 2000
    ..To investigate the role of the alpha7 nAChR subunit in cardiac autonomic function, we measured baroreflex-mediated responses in alpha7 null mice...
  27. ncbi Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
    K T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 21:4125-33. 2001
    ..In vivo elevation of Abeta, such as that exhibited in an animal model for AD, leads to the upregulation of alpha7 nAChR protein...
  28. ncbi Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures
    Davide Franceschini
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Brain Res Mol Brain Res 98:29-40. 2002
    ..nicotinic acetylcholine receptors (nAChRs) represent the major binding site for alpha-BTX, mice lacking the alpha7 nAChR subunit were predicted to be less sensitive to the convulsive effects of nicotine...
  29. pmc Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium
    Juan Arredondo
    Department of Dermatology, UC Davis Medical Center, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
    J Cell Biol 159:325-36. 2002
    ..We found that keratinocyte alpha7 nAChR controls homeostasis and terminal differentiation of epidermal keratinocytes required for formation of the skin ..
  30. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Here we report that the nicotinic acetylcholine receptor alpha7 subunit is required for acetylcholine inhibition of macrophage TNF release...
  31. ncbi Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor
    Jared W Young
    Fujisawa Institute of Neuroscience, Division of Neuroscience, University of Edinburgh, Edinburgh, UK
    Neuropsychopharmacology 29:891-900. 2004
    ..which nicotinic acetylcholine receptor (nAChR) subtype(s) mediate this effect, we examined the performance of alpha7 nAChR knockout (KO) mice in the 5-CSR task...
  32. ncbi Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus
    Manickavasagon Alkondon
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 24:4635-48. 2004
    It has been postulated that endogenous kynurenic acid (KYNA) modulates alpha7* nicotinic acetylcholine receptor (nAChR) and NMDA receptor activities in the brain...
  33. ncbi Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    Wouter J de Jonge
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Nat Immunol 6:844-51. 2005
    ..STAT3 was phosphorylated by the tyrosine kinase Jak2 that was recruited to the alpha7 subunit of the nicotinic acetylcholine receptor...
  34. ncbi Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development
    Paul R Reynolds
    Department of Internal Medicine, Pulmonary Division, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    J Biol Chem 280:32548-54. 2005
    ..A model is also supported whereby alpha(7) is induced by the essential pulmonary transcription factor TTF-1 and suppressed by Egr-1 during pulmonary development...
  35. ncbi The role of nicotinic acetylcholine receptors in lymphocyte development
    Marina Skok
    Department of Molecular Immunology, Palladin Institute of Biochemistry, 01601 Kiev, Ukraine
    J Neuroimmunol 171:86-98. 2006
    ..In chimera mice, either beta2 or alpha7 subunits influenced lymphocyte populations in primary lymphoid organs, while in the spleen, only alpha7 receptors ..
  36. ncbi Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 527:77-85. 2005
    ..that donepezil, a central-type acetylcholinesterase inhibitor, showed neuroprotective action via alpha4-and alpha7-nicotinic acetylcholine receptors against glutamate neurotoxicity in rat cortical culture...
  37. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ..Vagus nerve stimulation inhibits proinflammatory cytokine production by signaling through the alpha7 nicotinic acetylcholine receptor subunit...
  38. pmc Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons
    Jingming Zhang
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Physiol 579:753-63. 2007
    ..A major species of neuronal nAChRs contains the alpha7 gene product and has a high relative permeability to calcium...
  39. ncbi Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice
    J Egea
    Instituto Teófilo Hernando and Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo, 4, 28029 Madrid, Spain
    Neuroscience 145:866-72. 2007
    Although alpha7-receptors are considered the main target for neuroprotection, other receptor subtypes (alpha4beta2 or alpha3beta4) have also been implicated...
  40. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007
    ..In these studies, we tested the potential role of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) in a rodent model of acid-induced acute lung injury...
  41. pmc Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway
    Claude Sadis
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS ONE 2:e469. 2007
    ..This cholinergic anti-inflammatory pathway acts via the alpha7 nicotinic acetylcholine receptor (alpha7nAChR)...
  42. pmc Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 89:106-13. 2008
    ..However, the nicotinic acetylcholine receptors (nAChR) that are involved in nicotine withdrawal deficits in contextual fear conditioning are unknown...
  43. pmc Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation
    Amber V Osborne-Hereford
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, United States
    J Neuroimmunol 193:130-9. 2008
    The anti-inflammatory effects of the neuronal nicotinic receptor alpha7 (nAChRalpha7) are proposed to require acetylcholine release from vagal efferents...
  44. ncbi Nicotinic acetylcholine receptors alpha4beta2 and alpha7 regulate myelo- and erythropoiesis within the bone marrow
    Lyudmyla M Koval
    Palladin Institute of Biochemistry, 9 Leontovicha Str, 10601 Kyiv, Ukraine
    Int J Biochem Cell Biol 40:980-90. 2008
    ..The presence of nicotinic receptors containing alpha4(beta2) and alpha7 subunits in the bone marrow cells of C57Bl/6 mice was shown by the binding of [125I]-alpha-bungarotoxin or [3H]-..
  45. pmc Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling
    William R Parrish
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:567-74. 2008
    The alpha7 subunit-containing nicotinic acetylcholine receptor (alpha7nAChR) is an essential component in the vagus nerve-based cholinergic anti-inflammatory pathway that regulates the levels of TNF, high mobility group box 1 (HMGB1), and ..
  46. doi Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis
    Ilona A J Giebelen
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 198:750-7. 2008
    The efferent vagus nerve can inhibit inflammation via interaction between acetylcholine and alpha7 cholinergic receptors.
  47. doi IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors
    Natsuko Kageyama-Yahara
    Department of Bioscience, Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    Biochem Biophys Res Commun 377:321-5. 2008
    ..Expression of mRNA of nAChR alpha4, alpha7, and beta2 subunits were detected in specially differentiated mucosal-type murine bone marrow-derived mast cells (..
  48. doi The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation
    Eva Maria Nicolussi
    Medical University Vienna, Center for Brain Research, Department of Neuroimmunology, Spitalgasse 4, Vienna, Austria
    Neurobiol Dis 35:24-31. 2009
    Stimulation of the nicotinic alpha7 acetylcholine receptor (nAChRalpha7) by nicotine or acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural inhibition of inflammation...
  49. pmc Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels
    Nathanial P Brooks
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80303, USA
    Brain Res 1263:1-9. 2009
    ..binding, but not alpha7 RNA levels, suggests that the observed linkage between Chrna7 genotype and alpha-bungarotoxin levels may be due to genetic influences on the post-transcriptional regulation of alpha7 nicotinic receptor expression.
  50. pmc {alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation
    Kamel Maouche
    INSERM UMRS, Universite de Reims Champagne Ardenne, Reims, France
    Am J Pathol 175:1868-82. 2009
    ..Here, we have investigated the potential role of the alpha7 nAChR in the regulation of airway epithelial basal cell proliferation and the differentiation of the human airway ..
  51. doi Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses
    Eran Nizri
    Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Immunol 183:6681-8. 2009
    ..In this study, we determined the immunological effects of alpha7 nAChR activation by nicotine...
  52. pmc Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury
    Xiao Su
    Center for Lung and Vascular Biology and Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Immunol 184:401-10. 2010
    Although activation of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) modulates the response to sepsis, the role of this pathway in the development of sepsis-induced acute lung injury (ALI) is not known...
  53. pmc Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes
    Reinhard David
    Department of Biochemistry and Molecular Biology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Eur J Neurosci 31:978-93. 2010
    ..nAChRs in the mouse superior cervical ganglion (SCG), the function of distinct receptors (obtained by deletions of nAChR subunit genes) and mechanisms at the level of nAChRs that might compensate for the loss of subunits...
  54. pmc Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA Medical Center, USA
    J Neuroinflammation 7:38. 2010
    ..Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor (nAChR) alpha7.
  55. pmc Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis
    Geber Peña
    Laboratory of Immunity and Infection, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Eur J Immunol 40:2580-9. 2010
    ..Stattic also prevented the production of late mediators of sepsis and improved survival in established sepsis. These results reveal the immunological implications of tyrosine-unphosphorylated STAT3 in infectious diseases...
  56. doi Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1ΔE9 mice
    Andreas Söderman
    Department of Anatomy, University of Aarhus, Wilhelm Meyers Alle, 8000 Arhus C, Denmark
    Neurosci Lett 487:325-9. 2011
    Amyloid β (Aβ) plays a central role in Alzheimer's disease (AD) and binds to the nicotinic α(7) receptor (α(7) nAChR)...
  57. pmc α7-cholinergic receptor mediates vagal induction of splenic norepinephrine
    Gergely Vida
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 186:4340-6. 2011
    ..7nAChR represents a unique molecular link between the parasympathetic and sympathetic system to control inflammation...
  58. doi Dynamic alterations of gene expression of nicotinic acetylcholine receptor α7, α4 and β2 subunits in an acute MPTP-lesioned mouse model
    Jun Hu
    Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Guang Zhou Road 300, Nanjing 210029, China
    Neurosci Lett 494:232-6. 2011
    ..However, the alterations in gene expression of nAChR subunits using an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model remain unclear...
  59. pmc Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis
    Valentin Galitovskiy
    Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA
    J Immunol 187:2677-87. 2011
    ..The dichotomous action of nicotine resulted from the up- and downregulation of anti-inflammatory α7 nAChR on colonic CD4 T cells induced by cytokines characteristic of the inflammatory milieu in oxazolone (IL-4) and TNBS ..
  60. doi Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention
    Karine Guillem
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, Netherlands
    Science 333:888-91. 2011
    ..Acetylcholine (ACh) levels in the brain diminish with aging, and nicotinic ACh receptor (nAChR) stimulation is known to enhance cognitive performance...
  61. pmc Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors
    Cherry Wongtrakool
    Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA
    Am J Respir Cell Mol Biol 46:695-702. 2012
    ..Prenatal nicotine exposure decreases forced expiratory flows in offspring through α7 nAChR-mediated signals, and the critical period of nicotine exposure was between Prenatal Day 14 and Postnatal Day 7...
  62. doi Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice
    Nicola Origlia
    Neuroscience Institute National Council of Research CNR, Pisa, Italy
    Invest Ophthalmol Vis Sci 53:1211-8. 2012
    ..The impact of α7 homomeric nAChRs on visual function was investigated using mutant mice lacking the α7 nicotinic receptor subunit...
  63. pmc Endogenously released ACh and exogenous nicotine differentially facilitate long-term potentiation induction in the hippocampal CA1 region of mice
    Sakura Nakauchi
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Eur J Neurosci 35:1381-95. 2012
    ..Thus, our study demonstrates that the activation of α7- and β2-containing nAChRs differentially facilitates LTP induction via endogenously released ACh and exogenous nicotine, respectively, in the hippocampal CA1 region of mice...
  64. pmc Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, Salt Lake City, Utah, USA
    Am J Med Genet A 158:1135-44. 2012
    ..Here, we provide the first genetic delineation of cholinergic nicotinic receptor alpha7 (Chrna7) expression and link the ablation of the Chrna7 cell lineage to this condition in the mouse...
  65. pmc Sperm epidermal growth factor receptor (EGFR) mediates α7 acetylcholine receptor (AChR) activation to promote fertilization
    Yael Jaldety
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Biol Chem 287:22328-40. 2012
    ..In conclusion we suggest that activation of α7 by ZP leads to SFK-dependent EGFR activation, Ca(2+) influx, and the acrosome reaction...
  66. pmc Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy
    Scott W Rogers
    Geriatric Research, Education and Clinical Center, Veteran s Administration, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e36467. 2012
    The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green ..
  67. pmc Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure
    Kamel Maouche
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche Santé 903, 51092 Reims, France
    Proc Natl Acad Sci U S A 110:4099-104. 2013
    ..Here we identify α7 nAChR as a key regulator of CFTR in the airways...
  68. doi Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model
    Seo Eun Lee
    Department of Biomedical Sciences, Graduate School of Hanyang University, Seoul 133 791, South Korea
    Neurosci Lett 548:291-5. 2013
    It has been suggested that activation of alpha7 nicotinic acetylcholine receptors (α7nAChR) could alleviate acute and chronic pain in various abnormal pain models...
  69. ncbi Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes
    J A Stitzel
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    J Pharmacol Exp Ther 284:1104-11. 1998
    ..Levels of alpha-BTX binding did not correlate with nicotine-induced seizure sensitivity or overall nicotine sensitivity score in any of the four brain regions examined...
  70. ncbi Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis
    Juan Arredondo
    Department of Dermatology, University of California, Davis, 4860 Y Street, 3400, Sacramento, CA 95817, USA
    Life Sci 72:2063-7. 2003
    ..Herein, we report that cutaneous alpha7 nAChR plays a role in the physiological control of cutaneous homeostasis...
  71. ncbi A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant
    Barbara J Morley
    Boys Town National Research Hospital, 555 North 30th St, Omaha, NE 68131, USA
    Brain Res 1023:41-7. 2004
    ..On a molecular level, the alpha7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes...
  72. ncbi Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning
    J M Wehner
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309 0447, USA
    Neuroscience 129:11-24. 2004
    ..or co-administration of nicotine and ethanol were examined in wild type and homozygous null mutant mice from alpha7, beta2, beta3, and beta4 mouse lines at 24 h after training...
  73. ncbi Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice
    Jared W Young
    Astellas CNS Research in Edinburgh, The University of Edinburgh, The Chancellor s Building, 49 Little France Crescent, EH16 4SB, UK
    Eur Neuropsychopharmacol 17:145-55. 2007
    b>alpha7-Nicotinic acetylcholine receptors (alpha7-nAChR) have been implicated in a range of cognitive deficits in schizophrenia...
  74. ncbi The role of nicotinic receptor alpha 7 subunits in nicotine discrimination
    I P Stolerman
    Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuropharmacology 46:363-71. 2004
    ..The experiments described here use mice lacking the alpha7 subunit of nicotinic receptors to investigate the role of alpha7-containing receptors in nicotine discrimination...
  75. pmc Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice
    Young Hwan Jo
    Department of Anatomy and Cell Biology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 25:11133-44. 2005
    ..Based on pharmacological studies and comparisons of wild-type versus alpha7 nAChR subunit mutant mice, we propose that alpha7*-nAChRs are required for the modulation of GABAergic inputs in LH...
  76. pmc Role of α7- and β4-containing nicotinic acetylcholine receptors in the affective and somatic aspects of nicotine withdrawal: studies in knockout mice
    Astrid K Stoker
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Behav Genet 42:423-36. 2012
    ..brain reward function and the somatic signs of nicotine withdrawal were assessed in mice that lack α7 and β4 nAChR subunits...
  77. doi Subunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors
    Boris Lamotte d'Incamps
    Neurophysique et Physiologie, CNRS UMR 8119, Universite Paris Descartes, France
    Biochem Pharmacol 86:1114-21. 2013
    ..of the EPSC which is blocked by dihydro-beta-erythroidine (DHβE) with the dual objective of identifying the nAChR subunits involved and of understanding the kinetics of the response...
  78. doi Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice
    Emmanuel Somm
    Division of Development and Growth, Department of Paediatrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland Electronic address
    Mol Genet Metab 112:64-72. 2014
    ..Moreover, recent studies have revealed nAChR expression in nonneuronal cell types throughout the body, including tissues involved in metabolism...
  79. pmc Research tool: Validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches
    Caterina M Hernandez
    Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch at Galveston UTMB, Galveston, TX, USA Department of Neurology, UTMB, Galveston, TX, USA
    J Physiol 592:3201-14. 2014
    ..Therefore we have generated mice in which the fourth exon of the α7 nAChR gene (Chrna7) is flanked by loxP sites (B6-Chrna7(LBDEx4007Ehs)) which we refer to as floxed α7 nAChR conditional knockout or ..
  80. pmc Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria
    Galyna Gergalova
    Department of Molecular Immunology, Palladin Institute of Biochemistry, Kyiv, Ukraine
    PLoS ONE 7:e31361. 2012
    ..Outer membranes of mitochondria from the wild-type and β2-/- but not α7-/- mice bound α7 nAChR-specific antibody and toxins: FITC-labeled α-cobratoxin or Alexa 555-labeled α-bungarotoxin...
  81. ncbi Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms
    S Fitter
    The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Post Office Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia
    Biochim Biophys Acta 1398:75-85. 1998
    ..Cd151 maps to chromosome 7, in close linkage to the p gene (OCA2 in humans), and helps define a boundary in the human/mouse homology relationships...
  82. ncbi Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions
    B F O'Hara
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Brain Res Mol Brain Res 66:71-82. 1999
    ..b>alpha7 mRNA increases substantially while beta2 mRNA is relatively abundant throughout development...
  83. ncbi Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1
    Ines Ibanez-Tallon
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, New York, NY 10021, USA
    Neuron 33:893-903. 2002
    ....
  84. ncbi Functional nicotinic acetylcholine receptor expression on stem and progenitor cells of the early embryonic nervous system
    A S Schneider
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Ann N Y Acad Sci 971:135-8. 2002
    ..We now report the first evidence of functional nicotinic ACh receptors on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10...
  85. ncbi Identification of an alternatively processed nicotinic receptor alpha7 subunit RNA in mouse brain
    Philip A Saragoza
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109 0930, USA
    Brain Res Mol Brain Res 117:15-26. 2003
    ..and characterization of a previously unidentified alternatively processed RNA for the neuronal nicotinic receptor alpha7 subunit...
  86. ncbi Mapping of putative ether-anesthesia resistance gene using C57BL/6J and MSM/Ms mouse strains
    Tsuneo Megumi
    Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai, Japan
    J Anesth 18:267-76. 2004
    ..We attempted to identify the locations of major mouse genes responsible for sensitivity to diethylether (ether) anesthesia, using microsatellite linkage analyses including Quantitative Trait Locus (QTL) analysis...
  87. ncbi Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado at Boulder, 447 UCB, Boulder, CO 80309, USA
    Alcohol Clin Exp Res 29:295-302. 2005
    ..indicate that physiologically relevant concentrations of ethanol inhibit the functional activation of homomeric alpha7 nAChRs, which are one of the most abundant nAChR subtypes expressed in the mammalian brain...
  88. ncbi The pathophysiology of traumatic brain injury in alpha7 nicotinic cholinergic receptor knockout mice
    Matthew L Kelso
    College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Brain Res 1083:204-10. 2006
    The alpha7 nicotinic cholinergic receptor is a ligand-gated ion channel with calcium permeability similar to that of ionotrophic glutamate receptors...
  89. pmc Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice
    Corentin Le Magueresse
    Neurobiology Department, International School for Advanced Studies, Via Beirut 2 4, 34014 Trieste, Italy
    J Physiol 576:533-46. 2006
    ..Here, the patch-clamp technique was used to assess the contribution of alpha7 and beta2-containing (alpha7* and beta2*) nAChRs to nicotine-elicited modulation of GABAergic and glutamatergic ..
  90. ncbi Development of hippocampal alpha7 nicotinic receptors in C3H and DBA/2 congenic mice
    Catherine E Adams
    Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, and University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Brain Res 1122:27-35. 2006
    ..these developmental differences occur solely as a result of the different alleles of the alpha7 receptor gene (Chrna7) expressed by the two strains or whether strain-specific background factors also play a role...
  91. pmc beta2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice
    Jennifer A Davis
    Department of Psychology, Weiss Hall, Temple University, Philadelphia, PA, 19122, USA
    Psychopharmacology (Berl) 190:343-52. 2007
    ..Similarly, genetic deletion of the beta2 nAChR subunit but not the alpha7 nAChR subunit blocked the enhancing effect of nicotine on contextual fear conditioning.
  92. ncbi alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation
    K Ren
    Department of Pharmaceutics, Box 100494, University of Florida, Gainesville, FL 32610, USA
    Neuroscience 145:314-22. 2007
    Brain alpha7 nicotinic receptors have become therapeutic targets for Alzheimer's disease (AD) based on their memory-enhancing and neuroprotective actions...
  93. ncbi The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice
    K Ren
    Department of Pharmaceutics, 1600 Southwest Archer Drive, Box 100494, University of Florida, Gainesville, FL 32610, USA
    Neuroscience 148:230-7. 2007
    ..Hippocampal amyloid deposition was not affected by FFX lesions or treatment with this alpha7 nicotinic receptor agonist in APP/PS1 mice under these conditions...
  94. ncbi Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice
    Yoshihito X Fujii
    Department of Pharmacology, Kyoritsu College of Pharmacy, Minato ku, Tokyo 105 8512, Japan
    J Neuroimmunol 189:69-74. 2007
    ..that immune cell function is regulated by its own non-neuronal cholinergic system, at least in part, via alpha7 nAChR-mediated pathways...
  95. ncbi Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity
    Khosrow Rezvani
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:10508-19. 2007
    ..In particular, a 24 h exposure to nicotine decreased proteasome-dependent degradation of the alpha7 nicotinic acetylcholine receptor (nAChR) subunit, as indicated by the accumulation of ubiquitinated alpha7...
  96. ncbi Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3
    Rosa Andres
    Life Sciences Building, School of Biosciences, Museum Avenue, Cardiff CF10 3US, Wales, United Kingdom
    Neurosci Lett 431:241-6. 2008
    ....
  97. pmc Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice
    C E Adams
    Medical Research, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Brain Res 1194:138-45. 2008
    The alpha7 subtype of nicotinic receptor is highly expressed in the hippocampus where it is purported to modulate release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)...
  98. pmc PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity
    Fiana Levitin
    Department of Cell Research and Immunology, Tel Aviv University, Ramat Aviv, 69978 Israel
    J Biol Chem 283:16928-39. 2008
    ..Taken together, our findings indicate that in addition to participation of the PATE (Pate)-like genes in functions related to fertility and reproduction, some of them likely act as important modulators of neural transmission...
  99. pmc Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo
    Corey M McCann
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Ave, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 11:807-15. 2008
    ..Therefore, neurotransmitter receptor dynamism associated with rapid changes in synaptic efficacy precedes long-lasting structural changes in synaptic connectivity...
  100. doi Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro
    M Mousavi
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    Neurochem Int 54:237-44. 2009
    ..and at the same time lowered Abeta levels in both SH-SY5Y and SH-SY5Y/APPsw cells expressing alpha3 and alpha7 nAChR subtypes...
  101. pmc Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses
    Yi Fan Li
    Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA
    Neurosci Lett 462:20-3. 2009
    ..response was blocked by methyllycaconitine citrate, a selective alpha 7 nicotinic cholinergic receptor (nAchR) antagonist...

Research Grants21

  1. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2005
    ..abstract_text> ..
  2. Cholinergic Modulation of Inflammatory CNS Cytokines
    LORISE GAHRING; Fiscal Year: 2006
    ..abstract_text> ..
  3. Nicotine Modulation of Caspases in Non-Neuronal Cells
    LORISE GAHRING; Fiscal Year: 2006
    ..immune and inflammatory responses working through its 'neuronal' nicotinic acetylcholine receptors (nAChR) that are expressed by peripheral cells including lung epithelia, keratinocytes and lymphocytes...
  4. CENTER FOR NEUROSCIENCE EXCELLENCE
    Rodney L Parsons; Fiscal Year: 2010
    ....
  5. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
    ..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
  6. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  7. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  8. Nicotinic Receptors in Parkinson's Disease
    Maryka Quik; Fiscal Year: 2007
    ..These data together with the results of the behavioral studies may form a basis for the use of nicotinic drugs in the treatment of Parkinson's disease. [unreadable] [unreadable]..
  9. Nicotinic and neuroprotection in a parkinson mouse model
    Maryka Quik; Fiscal Year: 2007
    ..Our goal is to understand the effects of nigrostriatal damage and nicotine treatment on nicotinic receptor (nAChR) subtypes in the basal ganglia, and determine the relationship of any changes to neuroprotection...
  10. ESCHERICHIA COLI INVASION OF BRAIN ENDOTHELIAL CELLS
    Sheng He Huang; Fiscal Year: 2007
    ..To further characterize the role of IbeABP in E. coil K1 invasion of human BMEC. (3). To determine how E. coil K1 invasion gene expression is regulated by the IbeR and environmental signals (glucose and oxygen tension). ..
  11. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  12. Modulation of parasympathetic neurons by PACAP peptides
    RODNEY PARSONS; Fiscal Year: 2005
    ....
  13. TRANSIENT EXPRESSION OF CHOLINERGIC MARKERS IN THE PVCN
    Barbara J Morley; Fiscal Year: 2010
    ..Acetylcholine (ACh), acetylcholinesterase (AChE) and the a7 nicotinic acetylcholine receptor (nAChR) are among the neurochemicals that regulate synaptic events, including the expression of genes obligatory for ..
  14. SPERM GLYCINE RECEPTORS AND ZONA-INITIATED EXOCYTOSIS
    Stanley Meizel; Fiscal Year: 2006
    ..abstract_text> ..
  15. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  16. Identification of Functional nAChR Variants in Mice
    Jerry Stitzel; Fiscal Year: 2005
    ..that express functionally distinct isoforms of the neuronal nicotinic receptor subunits alpha3, alpha4, alpha6, alpha7, and beta2...
  17. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  18. Circadian Variations in Nicotine Sensitivity in Mice
    Jerry Stitzel; Fiscal Year: 2008
    ..This knowledge would be extremely useful for the development of better methods to treat nicotine addiction. [unreadable] [unreadable] [unreadable]..
  19. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  20. NICOTINIC RECEPTORS IN CEREBRAL CORTICAL DEVELOPMENT
    ALLAN SCHNEIDER; Fiscal Year: 2002
    ..The results of this project will lay the groundwork for further exploration of the role of nicotinic receptors in normal development and that of nicotine as a neuroteratogen. ..
  21. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....