Genomes and Genes
Gene Symbol: Chat
Description: choline acetyltransferase
Alias: B230380D24Rik, choline O-acetyltransferase, CHOACTase, choline acetylase
Publications146 found, 100 shown here
- Complementary expression and regulation of cadherins 6 and 11 during specific steps of motoneuron differentiationVeronique Marthiens
Signalisation et Différenciation Cellulaires dans les Systèmes Nerveux et Musculaire, INSERM U440 Université Paris 6, Institut du Fer a Moulin, Paris, France
Mol Cell Neurosci 20:458-75. 2002..These results strongly implicate cadherins 6 and 11 in the control of spinal motoneuron differentiation and segregation and in axoaxonal, axoglial, and glio-glial interactions during sensory-motor nerve progression...
- Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporterBaiping Wang
Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 104:14140-5. 2007..These results identify a physiological activity of APP in cholinergic neurons, and our data indicate that deregulation of APP function may contribute to cholinergic impairment and AD pathogenesis...
- Pet-1 is required across different stages of life to regulate serotonergic functionChen Liu
Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
Nat Neurosci 13:1190-8. 2010..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
- Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medullaStephan Oberle
Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
J Neurosci 26:1823-32. 2006..Thus, both somatic motoneurons and PSNs in the spinal cord depend on LIFRbeta signaling for their development and maintenance, although PSNs seem to be overall less affected than somatic motoneurons by LIFRbeta deprivation...
- Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiencyEugene P Brandon
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 24:5459-66. 2004Choline acetyltransferase (ChAT), the enzyme that synthesizes the neurotransmitter acetylcholine (ACh), is thought to be present in kinetic excess in cholinergic neurons...
- Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels Roberto Buccafusca
Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA
Mol Genet Metab 95:81-95. 2008..In conclusion, in neonatal brain tissue, Mrps6 gene expression may not be contingent on function of its embedded Slc5a3 gene, while inositide deficiency may not be the mechanism of lethal apnea in null Slc5a3 mice...
- Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrainJohn Jacob
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 136:2477-85. 2009..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
- Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plateJuan Antonio Moreno-Bravo
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
Dev Dyn 239:2094-101. 2010..The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei...
- Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiationS L Pfaff
Howard Hughes Medical Institute, Department of Biochemistry and Molecule Biophysics, Columbia University, New York, New York 10032, USA
Cell 84:309-20. 1996..These results show that ISL1 is required for the generation of motor neurons and suggest that motor neuron generation is required for the subsequent differentiation of certain interneurons...
- The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous systemM C Tiveron
Institut de Biologie du Developpement de Marseille, Centre National dela Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de la Mediterranée, Marseille, France
J Neurosci 16:7649-60. 1996..e., that of the medullary control reflexes of autonomic functions. This suggests that Phox2 could be involved in the establishment of these circuits...
- Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesisA Pattyn
Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, France
Development 124:4065-75. 1997..This suggests that Phox2b links early patterning events to the differentiation of defined neuronal populations in the hindbrain...
- The cholinergic gene locusL E Eiden
Section of Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4090, USA
J Neurochem 70:2227-40. 1998Messenger RNAs and the cognate gene(s) encoding choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) have been cloned from mammals and several other animal classes in the last decade...
- LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neuronsK Sharma
Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037, USA
Cell 95:817-28. 1998..Thus, Lhx3 and Lhx4 act in a binary fashion during a brief period in development to specify the trajectory of motor axons from the neural tube...
- Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identityS Arber
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Neuron 23:659-74. 1999..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs...
- Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient miceEugene P Brandon
Laboratory of Genetics and Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 23:539-49. 2003..developmental roles of acetylcholine (ACh) by establishing and analyzing mice lacking choline acetyltransferase (ChAT), the biosynthetic enzyme for ACh...
- The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrainYangu Zhao
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:9005-10. 2003..These results provide genetic evidence supporting an important role for Lhx8 in development of cholinergic neurons in the forebrain...
- Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleusM C Tiveron
CNRS UMR 6156, NMDA IBDM, Case 907 Parc Scientifique de Luminy, 13288, Marseille Cedex 9, France
Dev Biol 260:46-57. 2003....
- ATP-citrate lyase deficiency in the mouseAnne P Beigneux
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA
J Biol Chem 279:9557-64. 2004..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis...
- The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neuronsTetsuji Mori
Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295 Japan
Eur J Neurosci 19:3129-41. 2004..Neurotransmitter phenotypes other than cholinergic in the basal forebrain appeared intact. From these results, we suggested that L3/Lhx8 has a pivotal and specific role in the development and/or maintenance of BFCNs...
- c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant miceK Burau
Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
Eur J Neurosci 20:353-62. 2004..of the c-ret receptor in mice dramatically reduces numbers of cells positive for choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) in stellate ganglia of homozygous newborn animals...
- Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanismWeichun Lin
The Salk Institute, La Jolla, California 92037, USA
Neuron 46:569-79. 2005..Genetic elimination of Cdk5 or blocking ACh production prevents the dispersion of AChR clusters in agrin mutants. Therefore, we propose that ACh negatively regulates neuromuscular synapse formation through a Cdk5-dependent mechanism...
- Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient miceApostolia Fragkouli
Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Eur J Neurosci 21:2923-38. 2005..Overall our experiments demonstrate that Lhx7 expression is required for the specification or differentiation of cholinergic forebrain neurons involved in the processing of spatial information...
- Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitterThomas Misgeld
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 102:11088-93. 2005..Similar interactions between neurotransmitters and synaptic organizing molecules may operate at synapses in the central nervous system...
- Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse developmentEric Dessaud
INSERM UMR 623, Developmental Biology Institute of Marseille INSERM, CNRS, Case 907, 13288 Marseille Cedex 09, France
Mol Cell Neurosci 31:232-42. 2006..Comparison of its spatio-temporal expression pattern with that of two other members of this family, lynx1 and ly-6h, shows that these genes are detected both in distinct and overlapping neuron populations...
- Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retinaLiang Feng
Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
Development 133:4815-25. 2006..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
- The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neuronsYasser Elshatory
Medical Scientist Training Program, Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 28:3291-7. 2008..Together, these results demonstrate the requirement for Isl1 in the development of restricted telencephalic cholinergic neurons and link the development of cholinergic neurons in anatomically disparate sites to Isl1 function...
- Single-neuron labeling with inducible Cre-mediated knockout in transgenic micePaul Young
Department of Neurobiology, Duke University Medical Center, Research Drive, Durham, North Carolina 27710, USA
Nat Neurosci 11:721-8. 2008..Our results provide evidence for the long-term stability of inactive neuromuscular synapses in adult animals and demonstrate a Cre-loxP compatible system for dissecting gene functions in single identifiable neurons...
- Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2Xiuqian Mu
Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center and Graduate Training Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 105:6942-7. 2008..They also reveal that identical RGC expression patterns are achieved by different combinations of divergent inputs from upstream transcription factors...
- Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndromeChantal F Medina
Regenerative Medicine, Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6
Hum Mol Genet 18:966-77. 2009..These results implicate a role for Atrx in interneuron survival and differentiation...
- Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphologyThomas Rotolo
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
PLoS ONE 3:e4099. 2008....
- The vesicular acetylcholine transporter is required for neuromuscular development and functionBraulio M de Castro
Molecular Brain Research Group, Robarts Research Institute, University of Western Ontario, P O Box 5015, 100 Perth Drive, London, Ontario N6A 5K8, Canada
Mol Cell Biol 29:5238-50. 2009..The abnormalities are similar to those of mice that cannot synthesize ACh due to a lack of choline acetyltransferase. Our results indicate that VAChT is essential to the normal development of motor neurons and the release of ACh...
- LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneuronsApostolia Fragkouli
MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
Development 136:3841-51. 2009..These studies suggest that a LIM homeodomain transcriptional code confers cell-fate specification and neurotransmitter identity in neuronal subpopulations of the ventral forebrain...
- New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labelingTudor C Badea
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
PLoS ONE 4:e7859. 2009..Pharmacologic control of Cre-mediated recombination using tamoxifen-dependent activation of a Cre-estrogen receptor ligand binding domain fusion protein [CreER(T)] is widely used to modify and/or visualize cells in the mouse...
- DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retinaPeter G Fuerst
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Neuron 64:484-97. 2009..Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina...
- A robust and high-throughput Cre reporting and characterization system for the whole mouse brainLinda Madisen
Allen Institute for Brain Science, Seattle, Washington, USA
Nat Neurosci 13:133-40. 2010..Our expression data are displayed in a public online database to help researchers assess the utility of various Cre-driver lines for cell-type-specific genetic manipulation...
- Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failureAline Lara
Department of Physiology, Institute of Biological Sciences, Federal University of Minas Gerais, Av Antonio Carlos 6627, Belo Horizonte, MG CEP 31270 901, Brazil
Mol Cell Biol 30:1746-56. 2010..Our findings provide direct evidence that decreased cholinergic neurotransmission and underlying autonomic imbalance cause plastic alterations that contribute to heart dysfunction...
- Genetic dissection of the function of hindbrain axonal commissuresNicolas Renier
INSERM, U968, Paris, F 75012, France
PLoS Biol 8:e1000325. 2010..To our knowledge, this study is one of the first to link defects in commissural axon guidance with specific cellular and behavioral phenotypes...
- Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow controlXavier Caubit
Unité Mixte de Recherche UMR 6216, Centre National de la Recherche Scientifique CNRS, Universite de la Mediterranee, Institut de Biologie du Developpement de Marseille Luminy, Parc Scientifique de Luminy, Marseille Cedex 9, France
J Neurosci 30:9465-76. 2010..Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing...
- Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasisJari Rossi
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Metab 13:195-204. 2011..Re-expression of MC4Rs in cholinergic neurons (ChAT-Cre, loxTB MC4R mice) modestly reduced body weight gain without altering food intake and was sufficient to ..
- Novel strains of mice deficient for the vesicular acetylcholine transporter: insights on transcriptional regulation and control of locomotor behaviorCristina Martins-Silva
Molecular Brain Research Group, Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
PLoS ONE 6:e17611. 2011..VAChT gene is embedded within the first intron of the choline acetyltransferase (ChAT) gene, which provides a unique arrangement and regulation for these two genes...
- Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatumMichael J Higley
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e19155. 2011..Our results indicate that CINs are capable of mediating fast glutamatergic transmission, suggesting a new role for these cells in regulating striatal activity...
- Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmissionMonica S Guzman
Molecular Brain Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
PLoS Biol 9:e1001194. 2011..The data also raise the possibility of using VAChT as a target to boost dopaminergic function and decrease high striatal cholinergic activity, common neurochemical alterations in individuals affected with Parkinson's disease...
- Overexpression of the vesicular acetylcholine transporter increased acetylcholine release in the hippocampusP M Nagy
Brain Sciences Program, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
Neuroscience 218:1-11. 2012..It remains to be established whether, in cases of cholinergic deficits, increasing VAChT expression would re-establish adequate levels of cholinergic neurotransmission, thereby providing a valid therapeutic target...
- Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophyTara L Martinez
Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neurosci 32:8703-15. 2012..Our data suggest that SMN plays distinct roles in muscle, NMJs, and motor neuron somal synapses and that restored function of SMN at all three sites will be necessary for full recovery of muscle power...
- Wnt7A identifies embryonic γ-motor neurons and reveals early postnatal dependence of γ-motor neurons on a muscle spindle-derived signalSoha Ashrafi
Neuroscience Program, Weill Cornell Medical College, New York, New York 10065, USA
J Neurosci 32:8725-31. 2012..Furthermore, using Wnt7a expression as an early marker of γ-MN identity, we demonstrate a previously unknown dependence of γ-MNs on a muscle spindle-derived, GDNF-independent signal during the first postnatal week...
- Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuitsJyoti C Patel
Department of Neurosurgery, Physiology and Neuroscience, New York, New York 10016, USA
Nat Commun 3:1172. 2012..These results support a model in which forebrain and brainstem cholinergic systems act in tandem to regulate striatal dopamine signalling for proper control of motor activity...
- New modules are added to vibrissal premotor circuitry with the emergence of exploratory whiskingJun Takatoh
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 77:346-60. 2013..Thus, neural modules that are well suited to facilitate the bilateral coordination and cortical control of whisking are added to the premotor circuitry in parallel with the emergence of this exploratory behavior...
- Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neuronsJong Woo Sohn
Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Cell 152:612-9. 2013....
- ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domainsBenjamin Kolisnyk
Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5K8
J Neurosci 33:10427-38. 2013..transgenic mice expressing channelrhodopsin-2 (ChR2) protein under the control of the choline acetyltransferase (ChAT) promoter (ChAT-ChR2-EYFP) to dissect cholinergic circuit connectivity and function using optogenetic approaches...
- Forebrain deletion of the vesicular acetylcholine transporter results in deficits in executive function, metabolic, and RNA splicing abnormalities in the prefrontal cortexBenjamin Kolisnyk
Robarts Research Institute, Graduate Program in Neuroscience, Department of Physiology and Pharmacology, Department of Anatomy and Cell Biology, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5K8, and Department of Biological Chemistry and The Edmond and Lily Safra Center of Brain Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
J Neurosci 33:14908-20. 2013..We propose that VAChT-targeted mice can be used to model and to dissect the neurochemical basis of executive abnormalities. ..
- Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophyShingo Kariya
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
Hum Mol Genet 17:2552-69. 2008..We suggest that SMA might best be described as a NMJ synaptopathy and that one promising means of treating it could involve maintaining function at the NMJ...
- Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferaseThomas Misgeld
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuron 36:635-48. 2002..At subsequent stages, neurotransmission delays some steps in synaptic maturation but accelerates others. Thus, neurotransmission affects synaptogenesis from early stages and coordinates rather than drives synaptic maturation...
- GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglionJ Nishino
Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
Neuron 23:725-36. 1999..These observations suggest that GFR alpha3-mediated signaling is required both for the rostral migration of SCG precursors and for the survival of mature SCG neurons...
- Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosisJun Lei
Department of Neurosciences and Program in Neurosciences and Neurodegenerative Diseases, University of Toledo Health Sciences Campus, Toledo, OH 43614, USA
Development 138:4789-800. 2011..Thus, Hand2 is essential for neurogenesis, neurotransmitter specification and neural network patterning in the developing ENS...
- Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca²⁺-dependent Cl⁻ and K⁺ channelsMonika I Hollenhorst
Institute of Animal Physiology, Justus Liebig University Giessen, Giessen, Germany
Br J Pharmacol 166:1388-402. 2012..Thus, this study focused on the effect of luminal ACh as a regulator of transepithelial ion transport in epithelial cells...
- Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycleMonica S Guzman
Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
J Neurochem 124:658-69. 2013..These new insights on how cholinergic neurons influence homeostasis open new avenues for the search of drug targets to treat obesity...
- Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesisChunqiao Liu
Neurobiology Neurodegeneration and Repair Laboratory N NRL, National Eye Institute, MSC0610, 6 Center Drive, Bethesda, MD 20892, USA
Hum Mol Genet 22:2234-46. 2013..Our studies implicate Pk1 function in axonal-dendritic development associated with the maturation of CNS neurons...
- Survey on amacrine cells coupling to retrograde-identified ganglion cells in the mouse retinaJi Jie Pang
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
Invest Ophthalmol Vis Sci 54:5151-62. 2013..The total number and subtypes of ACs coupled to the entire GC population were investigated in wild-type and three lines of transgenic mice...
- BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infectionKerry J Lavender
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT
Blood 122:4013-20. 2013..The lack of GVHD makes the TKO-BLT mouse a significantly improved model for long-term studies of pathogenesis, immune responses, therapeutics, and vaccines to human pathogens. ..
- The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouseLisa A Ehrman
Divisions of Developmental Biology, Neurosurgery, Experimental Hematology and Cancer Biology and Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati OH 45229
Proc Natl Acad Sci U S A 110:E4026-35. 2013....
- Cholinergic signals in mouse barrel cortex during active whisker sensingEmmanuel Eggermann
Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
Cell Rep 9:1654-60. 2014....
- Feedback in the brainstem: an excitatory disynaptic pathway for control of whiskingDavid W Matthews
Graduate Program in Neuroscience, University of California, San Diego, La Jolla, CA, 92093, USA Department of Physics, University of California, San Diego, La Jolla, CA, 92093, USA
J Comp Neurol 523:921-42. 2015..These anatomical results suggest a general role of disynaptic architecture in fast positive feedback for motor output that drives active sensation...
- Silencing of Cholinergic Basal Forebrain Neurons Using Archaerhodopsin Prolongs Slow-Wave Sleep in MiceYu feng Shi
Department of Neurobiology and Physiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
PLoS ONE 10:e0130130. 2015..Our results indicate that the main effect of these neurons is to terminate SWS, whereas wakefulness or REM sleep may be determined by co-operation of the cholinergic BF neurons with other arousal-sleep control systems. ..
- Dorsal Medial Habenula Regulation of Mood-Related Behaviors and Primary Reinforcement by Tachykinin-Expressing Habenula NeuronsYun Wei A Hsu
Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, Washington 98101
Eneuro 3:. 2016..Together, our data show that the dMHb is involved in the regulation of multiple mood-related behaviors, but also support the idea that these behaviors do not reflect a single functional pathway. ..
- Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuitMauricio Rosas-Ballina
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Science 334:98-101. 2011..Thus, action potentials originating in the vagus nerve regulate T cells, which in turn produce the neurotransmitter, acetylcholine, required to control innate immune responses...
- Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatumRita Lopes
Division of Molecular Neurobiology, Medical Research Council, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
Proc Natl Acad Sci U S A 109:3119-24. 2012....
- A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencingLinda Madisen
Allen Institute for Brain Science, Seattle, Washington, USA
Nat Neurosci 15:793-802. 2012..When combined with the hundreds of available Cre driver lines, this optimized toolbox of reporter mice will enable widespread investigations of neural circuit function with unprecedented reliability and accuracy...
- Genetic dissection of midbrain dopamine neuron development in vivoDebra Ellisor
Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, 70 Ship St, Providence, RI 02903, USA
Dev Biol 372:249-62. 2012..By placing Wnt1, Fgf8, and En1/2 in the context of their temporal requirement for MbDA neuron development, we further deciphered the developmental program underpinning MbDA neuron progenitors...
- Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiationAmanda C Martyn
Molecular Brain Research Group, Robarts Research Institute, and Department of Anatomy and Cell Biology and Physiology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5K8
Proc Natl Acad Sci U S A 109:17651-6. 2012..These data uncover the specific contribution of forebrain cholinergic tone for synaptic plasticity and behavior. Moreover, these experiments define specific cognitive functions that could be targeted by cholinergic replacement therapy...
- Sustained Hox5 gene activity is required for respiratory motor neuron developmentPolyxeni Philippidou
Howard Hughes Medical Institute, New York University School of Medicine, Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York, New York, USA
Nat Neurosci 15:1636-44. 2012..These findings indicate that Hox5 genes orchestrate PMC development through deployment of temporally distinct wiring programs...
- Egr2::cre mediated conditional ablation of dicer disrupts histogenesis of mammalian central auditory nucleiElena Rosengauer
Department of Neurogenetics, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
PLoS ONE 7:e49503. 2012..Together our data identify a critical role of Dicer activity during embryonic development of the auditory brainstem...
- Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neuronsErik Keimpema
European Neuroscience Institute at Aberdeen, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
Proc Natl Acad Sci U S A 110:1935-40. 2013..These data indicate that NGF can orchestrate endocannabinoid signaling to promote cholinergic differentiation and implicate BRCA1 in determining neuronal morphology...
- Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanismsYoshihiko Kakinuma
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan
J Am Heart Assoc 2:e004887. 2013..Such a mismatch and missing link suggest the existence of a nonneuronal cholinergic system in ventricular myocardium...
- The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversificationAlessandro Furlan
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden
EMBO J 32:1613-25. 2013....
- NCAM in the organ of Corti of the developing mouseD S Whitlon
Department of Neurology, University of Wisconsin, Madison
J Neurocytol 19:970-7. 1990..NCAM is also present along the growth path of the nerve fibres. These studies suggest that NCAM is properly positioned in the cochlea for possible roles in axon guidance and nerve-target interactions...
- Analysis of CAG trinucleotide repeats from mouse cDNA sequencesC Abbott
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
Ann Hum Genet 58:87-94. 1994..containing variable length CAG repeats, seven in absentia homologue 1b (Sinh1b), and choline acetyl transferase (Chat), which had not previously been mapped in the mouse genome, were mapped by linkage analysis in an interspecific ..
- Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutantsS Schneider-Maunoury
Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
Development 124:1215-26. 1997..This navigational error could explain the disappearance, at around 17.5 dpc, of the trigeminal motor nucleus in Krox-20(-/-) embryos by inadequate supply of essential, possibly arch-specific survival factors...
- Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deteriorationC Andres
Department of Biological Chemistry, The Hebrew University of Jerusalem, 91904 Israel
Proc Natl Acad Sci U S A 94:8173-8. 1997....
- Molecular characterization of the mouse vesicular acetylcholine transporter geneJ M Naciff
Department of Molecular and Cellular Physiology, University of Cincinnati, College of Medicine, OH 45267 0576, USA
Neuroreport 8:3467-73. 1997The organization of the mouse choline acetyltransferase (ChAT) gene has been previously analyzed. Here we show that the first intron of the mouse ChAT gene contains an uninterrupted open reading frame...
- The origin and development of the vagal and spinal innervation of the external muscle of the mouse esophagusQ Sang
Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia
Brain Res 809:253-68. 1998....
- Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoformY Saga
Banyu Tsukuba Research Institute Merck Tsukuba, Ibaraki, 300 33 Japan
Genes Cells 4:219-28. 1999..In contrast to the widespread expression of RXRalpha and RXRbeta, the expression of RXRgamma is restricted to particular tissues in which RXRgamma1 is the major isoform expressed in the mouse corpus striatum...
- Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14E Rasmussen
Department of Psychiatry and Psychology, State University of New York at Stony Brook, Stony Brook, New York, USA
J Pharmacol Exp Ther 290:1337-46. 1999..A second QTL was detected on chromosome 14 (peak LOD = 6.9), which was located more proximally and included the Chat locus...
- Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genesH Usui
Department of Molecular Neuropathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Japan
Gene 248:127-35. 2000..Northern blot analysis showed that the Sfmbt mRNAs were expressed most abundantly in the adult testis, and less intensively in all other tissues examined...
- Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3Y Qian
The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 15:2533-45. 2001....
- Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expressionTiffany Mellott
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Eur J Biochem 269:850-8. 2002The expression of the choline acetyltransferase (ChAT) enzyme that synthesizes the neurotransmitter acetylcholine (ACh) is upregulated by ciliary neurotrophic factor (CNTF)...
- Evidence for a cell-specific action of Reelin in the spinal cordPatricia E Phelps
Department of Physiological Science, UCLA, Los Angeles, California 90095 1527, USA
Dev Biol 244:180-98. 2002..These results suggest that Reelin acts in a cell-specific manner on the migration of cholinergic spinal cord neurons...
- Developmental timing of hair follicle and dorsal skin innervation in miceEva M J Peters
Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg D 20246, Germany
J Comp Neurol 448:28-52. 2002..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis...
- Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrainToshio Ohshima
Laboratory for Developmental Neurobiology, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
J Neurosci 22:4036-44. 2002..These results indicate that Cdk5/p35 and Reelin signaling regulates the selective mode of neuronal migration in the developing mouse hindbrain...
- FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signalsRas Trokovic
Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland
EMBO J 22:1811-23. 2003..In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border...
- Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout miceShawn M Ferguson
Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 101:8762-7. 2004..Our results demonstrate that CHT is an essential and regulated presynaptic component of cholinergic signaling and indicate that CHT warrants consideration as a candidate gene for disorders characterized by cholinergic hypofunction...
- Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2M I Ransome
Neural Regeneration Laboratory, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria 3010, Australia
Neuroscience 132:673-87. 2005..Therefore, over-expression of SOCS2 variably affects different cortical regions and neuronal populations, with the predominant effect appearing to be on interneurons and neuronal connectivity in the cortex...
- Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdinSilvia Pagliardini
Department of Physiology, Centre of Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
Am J Pathol 167:175-91. 2005....
- Disruption and recovery of patterned retinal activity in the absence of acetylcholineRebecca C Stacy
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 25:9347-57. 2005..of cholinergic transmission by using a conditional mutant in which the gene encoding choline acetyltransferase (ChAT), the sole synthetic enzyme for acetylcholine (ACh), was deleted from large retinal regions...
- V1 spinal neurons regulate the speed of vertebrate locomotor outputsSimon Gosgnach
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 440:215-9. 2006....
- Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochleaLin Chien Huang
Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Development 134:2925-33. 2007..This reorganization also establishes the cochlea as a model system for studying CNS synapse development, plasticity and elimination...
- Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retinaKeely M Bumsted-O'Brien
Department of Neuroanatomy, Max Planck Institute for Brain Research, Deutschordenst 46, 60218 Frankfurt, Germany
J Comp Neurol 505:58-72. 2007....
- Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during developmentMargarita García-López
Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
J Comp Neurol 506:46-74. 2008..Our study provides a molecular and morphological foundation for understanding the complex embryonic origins and adult organization of the centromedial and extended amygdala...
- Mice lacking the transcription factor Ikaros display behavioral alterations of an anti-depressive phenotypeTim Rasmus Kiehl
Department of Pathology, University Health Network, 610 University Avenue, Toronto, Ontario, Canada
Exp Neurol 211:107-14. 2008....
- Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndromeEva K Wirth
Neuroscience Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany
J Neurosci 29:9439-49. 2009....
- Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent retina and the consequence of gene deletionJenny M Gunnersen
Brain Development, Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
PLoS ONE 4:e6546. 2009..Seizure-related gene 6 (Sez-6) is expressed in neurons of the mouse brain, retina and spinal cord. In the cortex, Sez-6 plays a role in specifying dendritic branching patterns and excitatory synapse numbers during development...
- MSC p43 required for axonal development in motor neuronsXiaodong Zhu
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
Proc Natl Acad Sci U S A 106:15944-9. 2009..Thus, MSC p43 is indispensable in maintaining axonal integrity. Its dysfunction may underlie the NF disorganization and axon degeneration associated with motor neuron degenerative diseases...
- SODIUM PUMP AND REGULATION OF NEURONAL EXCITABILITYBradley Alger; Fiscal Year: 2002..This proposal is a step towards filling the gap. ..
- Does cortex kill striatum in HD?CHRISTOPHER MEADE; Fiscal Year: 2004..These studies will validate the in oculo technique as an effective HD model system, which might be useful in further testing hypotheses of mutant Ht mechanism of action and in testing possible drug therapies. ..