Cgn

Summary

Gene Symbol: Cgn
Description: cingulin
Alias: 6330408J11Rik, cingulin
Species: mouse

Top Publications

  1. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
  2. pmc The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK
    Tomoki Yano
    Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Cell Biol 203:605-14. 2013
  3. doi Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo
    Klaudia Schossleitner
    From the Skin and Endothelium Research Division SERD, Department of Dermatology K S, S R, M G, H P F, R F, P P, Core Facility Imaging S R, M G, Department of Cardiac Surgery A H, Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center M S, Department of Surgery C B, and Department of Dermatology D F, Medical University of Vienna, Vienna, Austria and Department of Cell Biology and Institute of Genetics and Genomics in Geneva, University of Geneva, Switzerland S C
    Arterioscler Thromb Vasc Biol 36:647-54. 2016
  4. pmc Under construction: building the macromolecular superstructure and signaling components of an electrical synapse
    B D Lynn
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
    J Membr Biol 245:303-17. 2012
  5. doi Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    J Cell Sci 125:5005-14. 2012
  6. ncbi Epithelial differentiation and intercellular junction formation in the mouse early embryo
    T P Fleming
    Department of Biology, University of Southampton, UK
    Dev Suppl . 1992
  7. ncbi Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development
    T P Fleming
    Department of Biology, University of Southampton, UK
    Development 117:1135-44. 1993
  8. ncbi Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development
    Q Javed
    Department of Biology, University of Southampton, UK
    Development 117:1145-51. 1993
  9. ncbi Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction
    B Sheth
    Division of Cell Sciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
    Mech Dev 97:93-104. 2000
  10. ncbi A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation
    Saadia A Karim
    Applied Neurobiology Group, Institute of Comparative Medicine, Veterinary School, United Kingdom
    Genomics 83:225-30. 2004

Detail Information

Publications12

  1. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
    ..In conclusion, ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development...
  2. pmc The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK
    Tomoki Yano
    Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Cell Biol 203:605-14. 2013
    ..In a gel overlay assay with taxol-stabilized MTs, cingulin showed strong binding to MTs, and a domain analysis showed that this binding occurred through cingulin's N-..
  3. doi Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo
    Klaudia Schossleitner
    From the Skin and Endothelium Research Division SERD, Department of Dermatology K S, S R, M G, H P F, R F, P P, Core Facility Imaging S R, M G, Department of Cardiac Surgery A H, Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center M S, Department of Surgery C B, and Department of Dermatology D F, Medical University of Vienna, Vienna, Austria and Department of Cell Biology and Institute of Genetics and Genomics in Geneva, University of Geneva, Switzerland S C
    Arterioscler Thromb Vasc Biol 36:647-54. 2016
    b>Cingulin is a cytoplasmic component of tight junctions...
  4. pmc Under construction: building the macromolecular superstructure and signaling components of an electrical synapse
    B D Lynn
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
    J Membr Biol 245:303-17. 2012
    ..Here, we show by immunofluorescence labeling that the cytoskeletal-associated protein cingulin, commonly found at tight junctions, is also localized at neuronal gap junctions throughout the central nervous ..
  5. doi Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    J Cell Sci 125:5005-14. 2012
    b>Cingulin (CGN) is a 140 kDa protein, which is localized to the cytoplasmic region of vertebrate tight junctions (TJ), and regulates gene expression and RhoA signaling in cultured cells...
  6. ncbi Epithelial differentiation and intercellular junction formation in the mouse early embryo
    T P Fleming
    Department of Biology, University of Southampton, UK
    Dev Suppl . 1992
    ..sites gradually extend laterally to become zonular and acquire the peripheral tight junction proteins ZO-1 and cingulin. Our studies indicate that junction components assemble in a temporal sequence with ZO-1 assembly preceding that ..
  7. ncbi Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development
    T P Fleming
    Department of Biology, University of Southampton, UK
    Development 117:1135-44. 1993
    ..of the tight junction in the mouse early embryo has been investigated by monitoring the distribution of cingulin, a 140 x 10(3) M(r) peripheral (cytoplasmic) membrane constituent of the junction, at different stages of ..
  8. ncbi Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development
    Q Javed
    Department of Biology, University of Southampton, UK
    Development 117:1145-51. 1993
    The expression of the tight junction peripheral membrane protein, cingulin (140 x 10(3) M(r), was investigated in mouse eggs and staged preimplantation embryos by immunoblotting and immunoprecipitation...
  9. ncbi Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction
    B Sheth
    Division of Cell Sciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
    Mech Dev 97:93-104. 2000
    ..32-cell stage when blastocoel formation begins, ZO-1alpha- and other TJ proteins (ZO-1alpha+ isoform, occludin, cingulin) co-localized in an apical TJ which was separate from a subjacent E-cadherin/catenin zonula adherens complex...
  10. ncbi A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation
    Saadia A Karim
    Applied Neurobiology Group, Institute of Comparative Medicine, Veterinary School, United Kingdom
    Genomics 83:225-30. 2004
    ..Accordingly, our findings both map the area surrounding the hsh mutation and present important corrections to the current maps in an area rich in genes related to the nervous system...
  11. ncbi JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin
    Hiroe Ohnishi
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:46014-22. 2004
    ..cDNA of mouse p155 encoded a 148-kDa polypeptide containing a coiled-coil domain with sequence similarity to cingulin, a tight junction (TJ)-associated plaque protein...
  12. ncbi Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    J Cell Sci 117:5245-56. 2004
    b>Cingulin, a component of vertebrate tight junctions, contains a head domain that controls its junctional recruitment and protein interactions...