CGI 58

Summary

Gene Symbol: CGI 58
Description: abhydrolase domain containing 5
Alias: 1300003D03Rik, 2010002J10Rik, CDS, CGI-58, IECN5, NCIE2, 1-acylglycerol-3-phosphate O-acyltransferase ABHD5, abhydrolase domain-containing protein 5, lipid droplet-binding protein CGI-58
Species: mouse

Top Publications

  1. ncbi Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes
    Vidya Subramanian
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:42062-71. 2004
  2. pmc Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice
    Hongming Miao
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA Department of Biochemistry and Molecular Biology, The Third Military Medical University, Chongqing 400038, China
    Cell Rep 7:223-35. 2014
  3. pmc Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice
    Feng Guo
    Departments of Biochemistry and Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 54:2109-20. 2013
  4. pmc Functional cardiac lipolysis in mice critically depends on comparative gene identification-58
    Kathrin A Zierler
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 288:9892-904. 2013
  5. pmc CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action
    Caleb C Lord
    Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 61:355-63. 2012
  6. pmc Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5)
    Sheetal Gandotra
    Institute of Metabolic Science Metabolic Research Laboratories and the Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Biol Chem 286:34998-5006. 2011
  7. pmc Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein
    Hong Wang
    Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 286:15707-15. 2011
  8. pmc CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
    J Mark Brown
    Departments of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 51:3306-15. 2010
  9. pmc The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
    Astrid Gruber
    Institute of Molecular Biosciences, University of Graz, Humboldtstrasse, A 8010 Graz, Austria
    J Biol Chem 285:12289-98. 2010
  10. pmc Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)
    Franz P W Radner
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    J Biol Chem 285:7300-11. 2010

Research Grants

  1. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001
  2. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004

Scientific Experts

  • JAMES GRANNEMAN
  • Satish Patel
  • Sheetal Gandotra
  • M Akiyama
  • Ping Xie
  • Rudolf Zechner
  • Achim Lass
  • Martina Schweiger
  • Hang Shi
  • Bingzhong Xue
  • Liqing Yu
  • Robert Zimmermann
  • Hongming Miao
  • Feng Guo
  • Yinyan Ma
  • J Mark Brown
  • Juanjuan Ou
  • Guenter Haemmerle
  • Monika Oberer
  • Irina Cornaciu
  • Dawn L Brasaemle
  • Dan Yang
  • Caleb C Lord
  • Jenna L Betters
  • Tomohiro Yamaguchi
  • Franz P W Radner
  • Gabriele Schoiswohl
  • Houjie Liang
  • Andras Boeszoermenyi
  • Xianlin Han
  • Karina Preiss-Landl
  • Gabriela Montero-Moran
  • Manju Kumari
  • Jorge M Caviglia
  • Astrid Gruber
  • Matthew A Sanders
  • Peter Hofer
  • Xu Zeng
  • Anita Sahu-Osen
  • Lixia Gan
  • Miao Wang
  • Vidya Subramanian
  • Anil K G Kadegowda
  • Gregory Camus
  • Doris Jaeger
  • Madeleine Goeritzer
  • Dagmar Kolb
  • Gwynneth Thomas
  • Jennifer L Cantley
  • Tomoaki Inoue
  • Haruya Ohno
  • Kathrin A Zierler
  • Gerald Rechberger
  • Derek McMahon
  • George M Carman
  • Pierre Marie Badin
  • Xiuli Liu
  • Gerald I Shulman
  • Sandra Eder
  • Hong Wang
  • Mark J Graham
  • Jun Liu
  • Xingyuan Yang
  • Ananda K Ghosh
  • Lawrence Shapiro
  • Alexis Rothenberg
  • Naoto Omatsu
  • Takashi Osumi
  • Chang Liu
  • Haimei Chen
  • Xincun Wang
  • Xuan Zhang
  • Anna Dinh
  • Franck Madoux
  • Deanna Russell
  • Katarina Fritz
  • Huamei Zhang
  • Haribabu Arthanari
  • Peter Hodder
  • Fabian Zehender
  • Rolf Breinbauer
  • Joseph A Caruso
  • Leanne Groban
  • Yujuan Chen
  • Ruth Birner-Gruenberger
  • Emilio P Mottillo
  • Michelle Angrish
  • Ursula Feiler
  • William R Roush
  • Nicole Mayer

Detail Information

Publications40

  1. ncbi Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes
    Vidya Subramanian
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:42062-71. 2004
    ..Thus, CGI-58 binds to perilipin A-coated lipid droplets in a manner that is dependent upon the metabolic status of the adipocyte and the activity of cAMP-dependent protein kinase...
  2. pmc Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice
    Hongming Miao
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA Department of Biochemistry and Molecular Biology, The Third Military Medical University, Chongqing 400038, China
    Cell Rep 7:223-35. 2014
    ..Anti-ROS treatment also prevents exacerbation of inflammation and IR in HFD-fed MaKO mice. Our data thus establish CGI-58 as a suppressor of overnutrition-induced NLRP3 inflammasome activation in macrophages. ..
  3. pmc Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice
    Feng Guo
    Departments of Biochemistry and Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 54:2109-20. 2013
    ..In conclusion, CGI-58 deficiency in the liver directly causes not only hepatic steatosis but also steatohepatitis and fibrosis. ..
  4. pmc Functional cardiac lipolysis in mice critically depends on comparative gene identification-58
    Kathrin A Zierler
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 288:9892-904. 2013
    ..In summary, this study demonstrates that functional muscle lipolysis depends on both CGI-58 and ATGL...
  5. pmc CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action
    Caleb C Lord
    Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 61:355-63. 2012
    ..Collectively, these findings establish that CGI-58 provides a novel source of signaling lipids. These findings contribute insight into the basic mechanisms linking TH1 cytokine signaling to nutrient metabolism...
  6. pmc Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5)
    Sheetal Gandotra
    Institute of Metabolic Science Metabolic Research Laboratories and the Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Biol Chem 286:34998-5006. 2011
    ..The data also suggest that pharmacological inhibition of ATGL could have therapeutic potential in patients with this rare but metabolically serious disorder...
  7. pmc Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein
    Hong Wang
    Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 286:15707-15. 2011
    ..Our studies establish perilipin 5 as a novel ATGL partner and provide evidence that the protein composition of perilipins at the LD surface regulates lipolytic activity of ATGL...
  8. pmc CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
    J Mark Brown
    Departments of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 51:3306-15. 2010
    ....
  9. pmc The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
    Astrid Gruber
    Institute of Molecular Biosciences, University of Graz, Humboldtstrasse, A 8010 Graz, Austria
    J Biol Chem 285:12289-98. 2010
    ..In summary, our study shows that the N-terminal, Trp-rich region of CGI-58 is essential for correct localization and ATGL-activating function of CGI-58...
  10. pmc Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)
    Franz P W Radner
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    J Biol Chem 285:7300-11. 2010
    ..This mechanism may also underlie the pathogenesis of ichthyosis in neutral lipid storage disease patients lacking functional CGI-58...
  11. pmc CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase
    Gabriela Montero-Moran
    Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 51:709-19. 2010
    Mutations in human CGI-58/ABHD5 cause Chanarin-Dorfman syndrome (CDS), characterized by excessive storage of triacylglycerol in tissues. CGI-58 is an alpha/beta-hydrolase fold enzyme expressed in all vertebrates...
  12. ncbi CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome
    Tomohiro Yamaguchi
    Graduate School of Life Science, Himeji Institute of Technology, University of Hyogo, 3 2 1 Koto, Kamigori, Hyogo 678 1297, Japan
    J Biol Chem 279:30490-7. 2004
    ..between perilipin and CGI-58, a deficiency of which correlated with the pathogenesis of Chanarin-Dorfman syndrome (CDS)...
  13. ncbi Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Cell Metab 3:309-19. 2006
    ..Mutations in the human CGI-58 gene are associated with Chanarin-Dorfman Syndrome (CDS), a rare genetic disease where TG accumulates excessively in multiple tissues...
  14. ncbi Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 281:40236-41. 2006
    ..Together, ATGL and HSL are responsible for more than 95% of the TG hydrolase activity present in murine WAT. Additional known or unknown lipases appear to play only a quantitatively minor role in fat cell lipolysis...
  15. doi The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 283:17211-20. 2008
    ..Together, our results demonstrate that the C-terminal region of ATGL is essential for proper localization of the enzyme and suppresses enzyme activity...
  16. pmc Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulation
    James G Granneman
    Center for Integrative Metabolic and Endocrine Research, the Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Biol Chem 284:3049-57. 2009
    ..These results indicate that the interaction between Abhd5 and Mldp is dynamic and essential for regulating the activity of Atgl at lipid droplets containing Mldp...
  17. pmc Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)
    James G Granneman
    Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 284:34538-44. 2009
    ..Imaging experiments demonstrated that the Plin-dependent interaction of Abhd5 and Atgl occurs mainly, but not exclusively, on lipid droplets that contain Plin...
  18. pmc CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid
    Ananda K Ghosh
    Department of Biochemistry, Indian Institute of Science, Bangalore 562, India
    J Biol Chem 283:24525-33. 2008
    ..These observations suggest the existence of an alternate cytosolic phosphatidic acid biosynthetic pathway in the white adipose tissue. Collectively, these results reveal the role of cgi-58 as an acyltransferase...
  19. pmc Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling
    Peter Hofer
    From the Institute of Molecular Biosciences, University of Graz, NAWI Graz, 8010 Graz, Austria
    J Biol Chem 290:18438-53. 2015
    ..Our studies identify Fabps as crucial structural and functional components of the lipolysome. ..
  20. pmc Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle
    Matthew A Sanders
    Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cell Metab 22:851-60. 2015
    ..Our results reveal a new locus of lipolysis control and suggest ABHD5 ligands might be developed into novel therapeutics that directly promote fat catabolism. ..
  21. pmc Muscle-specific deletion of comparative gene identification-58 (CGI-58) causes muscle steatosis but improves insulin sensitivity in male mice
    Ping Xie
    Departments of Biochemistry P X, Y M, F G, L Y and Anesthesiology L G, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 Department of Animal and Avian Sciences A K G G, Y M, L Y, University of Maryland, College Park, Maryland 20742 Diabetes and Obesity Research Center X H, M W, Sanford Burnham Medical Research Institute, Orlando, Florida 32827 Department of Biology B X, H S, Georgia State University, Atlanta, Georgia 30303 and The Key Laboratory of Remodeling Related Cardiovascular Diseases H L, Capital Medical University, Ministry of Education, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated the Capital Medical University, Beijing 100029, People s Republic of China
    Endocrinology 156:1648-58. 2015
    ..In conclusion, muscle CGI-58 deficiency causes cardiac dysfunction and fat deposition in oxidative muscles but induces a series of favorable metabolic changes in mice fed a high-fat diet. ..
  22. pmc Loss of abhd5 promotes colorectal tumor development and progression by inducing aerobic glycolysis and epithelial-mesenchymal transition
    Juanjuan Ou
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA Department of Oncology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China
    Cell Rep 9:1798-811. 2014
    ..Our findings link Abhd5 to CRC pathogenesis and suggest that cancer cells develop aerobic glycolysis by suppressing Abhd5-mediated intracellular lipolysis. ..
  23. doi Macrophage CGI-58 deficiency promotes IL-1╬▓ transcription by activating the SOCS3-FOXO1 pathway
    Hongming Miao
    Department of Oncology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China
    Clin Sci (Lond) 128:493-506. 2015
    ..Collectively, our data suggest that obesity-associated factors such as NEFA and lipopolysaccharide (LPS) probably adopt this vicious cycle to promote inflammation and insulin resistance. ..
  24. pmc CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization
    Anita Sahu-Osen
    Research Unit Functional Proteomics and Metabolic Pathways, Institute of Pathology, Medical University of Graz, Graz, Austria A 8036, and Omics Center Graz, BioTechMed Graz, Graz, Austria A 8010
    J Lipid Res 56:109-21. 2015
    ..PKA-mediated phosphorylation of CGI-58 is required for dispersion of CGI-58 from perilipin 1A-coated lipid droplets, thereby increasing CGI-58 availability for ATGL coactivation. ..
  25. pmc The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets
    Gregory Camus
    From the Gladstone Institute of Virology and Immunology, San Francisco, California 94158
    J Biol Chem 289:35770-80. 2014
    ..These data link the anti-lipolytic activity of the HCV core protein with altered ATGL binding to CGI-58 and the enhanced association of both proteins with LDs. ..
  26. pmc Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis
    Madeleine Goeritzer
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
    J Lipid Res 55:2562-75. 2014
    ..These results suggest that macrophage function and atherosclerosis susceptibility differ fundamentally in these two animal models with disturbed TG catabolism, showing a more severe phenotype by ATGL deficiency. ..
  27. ncbi Transgenic CGI-58 expression in macrophages alleviates the atherosclerotic lesion development in ApoE knockout mice
    Ping Xie
    Biochim Biophys Acta 1841:1683-90. 2014
    ..Collectively, these data strongly suggest that CGI-58 overexpression in macrophages may protect against atherosclerosis development in mice...
  28. pmc Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis
    Satish Patel
    University of Cambridge Metabolic Research Laboratories, Wellcome Trust Medical Research Council Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
    Proc Natl Acad Sci U S A 111:9163-8. 2014
    ....
  29. doi Macrophage CGI-58 Attenuates Inflammatory Responsiveness via Promotion of PPAR╬│ Signaling
    Dan Yang
    Department of Computational Biology and Bioinformatics, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Cell Physiol Biochem 38:696-713. 2016
    ..Beyond its function in promoting lipolysis, other features of CGI-58 have been proposed. Here, we investigated the role of CGI-58 in the regulation of inflammatory responsiveness in macrophages...
  30. pmc Intestinal Cgi-58 deficiency reduces postprandial lipid absorption
    Ping Xie
    Department of Biochemistry, Wake Forest University Health Sciences, Winston Salem, North Carolina, United States of America Institute Of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 9:e91652. 2014
    ..Our animal model will serve as a valuable tool to further define how intestinal fat metabolism influences the pathogenesis of metabolic disorders, such as obesity and type 2 diabetes. ..
  31. pmc EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
    Haruya Ohno
    1 UCSF Diabetes Center, Department of Cell and Tissue Biology, University of California, San Francisco, 35 Medical Center Way, San Francisco, California 94143 0669, USA 2
    Nature 504:163-7. 2013
    ..These data indicate that EHMT1 is an essential enzymatic switch that controls brown adipose cell fate and energy homeostasis. ..
  32. doi Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice
    Tomoaki Inoue
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 438:224-9. 2013
    ..These results suggest that reduced ATGL and CGI-58 expression and increased TG synthesis may exacerbate myocardial steatosis and oxidative stress, thereby promoting cardiac apoptosis in diabetic mice. ..
  33. pmc Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase
    James G Granneman
    Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 286:5126-35. 2011
    ....
  34. pmc CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
    Jennifer L Cantley
    Howard Hughes Medical Institute and Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 110:1869-74. 2013
    ....
  35. pmc Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58
    Pierre Marie Badin
    Inserm 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, Toulouse, France
    J Lipid Res 53:839-48. 2012
    ....
  36. pmc The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively
    Irina Cornaciu
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    PLoS ONE 6:e26349. 2011
    ....
  37. pmc Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity
    Jorge M Caviglia
    Rutgers Center for Lipid Research and Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 52:2032-42. 2011
    ..The expression of ABHD5 in mouse adipose tissue is not limiting for either basal or stimulated lipolysis...
  38. ncbi CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation
    Tomohiro Yamaguchi
    Graduate School of Life Science, University of Hyogo, 3 2 1, Koto, Kamigori, Hyogo 678 1297, Japan
    J Lipid Res 48:1078-89. 2007
    ..CGI-58 is not required for this process. Thus, CGI-58 facilitates lipolysis in cooperation with perilipin and other factors, including lipases...
  39. pmc CGI-58 is an alpha/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes
    Masashi Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Am J Pathol 173:1349-60. 2008
    ..Our results indicate that CGI-58 is expressed and packaged into LGs during keratinization and likely plays crucial role(s) in keratinocyte differentiation and LG lipid metabolism, contributing to skin lipid barrier formation...
  40. pmc Identification of a novel splicing isoform of murine CGI-58
    Xingyuan Yang
    Department of Pediatrics, University of Kentucky, Lexington, KY 40536 0509, USA
    FEBS Lett 584:903-10. 2010
    ..Overexpression of mCGI-58S failed to promote lipid droplet turnover and loss of intracellular triacylglycerols. These results suggest that this splicing event may be involved in the regulation of lipid homeostasis...

Research Grants2

  1. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001
    ..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
  2. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004
    ..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma. ..