Cfc1

Summary

Gene Symbol: Cfc1
Description: cripto, FRL-1, cryptic family 1
Alias: AV265756, b2b970Clo, cryptic, cryptic protein
Species: mouse

Top Publications

  1. ncbi Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1
    C Xu
    Burnham Institute, La Jolla Cancer Research Center, California 92037, USA
    Dev Biol 196:237-47. 1998
  2. doi Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb
    Hidetaka Shiratori
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan Electronic address
    Dev Biol 395:331-41. 2014
  3. doi Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway
    Kimberly Fuller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States
    Dev Biol 391:182-95. 2014
  4. pmc The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 27:997-1002. 2013
  5. ncbi Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs
    Hidetaka Shiratori
    Developmental Genetics Group, Graduate School for Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST Yamada oka, Suita, Osaka 565 0871, Japan
    Development 133:3015-25. 2006
  6. doi Endogenous Nodal signaling regulates germ cell potency during mammalian testis development
    Cassy M Spiller
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Development 139:4123-32. 2012
  7. pmc Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo
    Ranajeet S Saund
    Department of Neurobiology and Anatomy, University of Utah Medical School, Salt Lake City, UT 84132 3401, USA
    Development 139:2426-35. 2012
  8. pmc Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway
    Yu Ting Yan
    Center for Advanced Biotechnology and Medicine and Department of Pediatric, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 22:4439-49. 2002
  9. ncbi Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo
    Shinya Oki
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST Yamada oka, Suita, Osaka 565 0871, Japan
    Development 134:3893-904. 2007
  10. ncbi A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation
    M M Shen
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA
    Development 124:429-42. 1997

Scientific Experts

  • Hidetaka Shiratori
  • Yukio Saijoh
  • M G Persico
  • David R C Natale
  • M M Shen
  • G Minchiotti
  • Shinya Oki
  • Jose Antonio Belo
  • Hiroshi Hamada
  • Kimberly Fuller
  • Sonja Nowotschin
  • X M Zhang
  • Cassy M Spiller
  • Ranajeet S Saund
  • Aiko Kawasumi
  • Elizabeth J Robertson
  • Jianhua Chu
  • Sebastian J Arnold
  • Giovanna L Liguori
  • Akihiko Ishimura
  • Gidi Shani
  • Naoki Mine
  • Axel Schweickert
  • Olov Andersson
  • Yu Liu
  • Masa aki Nakaya
  • Simon D Bamforth
  • Bradley J Merrill
  • Markus Morkel
  • JONATHAN EGGENSCHWILER
  • Takeshi Fujiwara
  • Joyce T O'Connell
  • Olivier Mauti
  • Julie Gordon
  • Yu Ting Yan
  • William H Klein
  • Anna Katerina Hadjantonakis
  • Anna Piliszek
  • Chai An Mao
  • Ita Costello
  • Gloria S Kwon
  • Mary T Lucero
  • Injune Kim
  • Masami Kanai-Azuma
  • Yoshiakira Kanai
  • Andrew Jackson
  • Antoine D Rolland
  • Josephine Bowles
  • Peter Koopman
  • Chun Wei Feng
  • M Ramalho-Santos
  • Leendert H J Looijenga
  • Ad J M Gillis
  • A P McMahon
  • Naomi Iwai
  • Tetsuya Nakamura
  • Kenta Yashiro
  • J F Colas
  • D S Saloman
  • R N Bamford
  • Keiko Kitajima
  • Chikara Meno
  • Sara Marques
  • Takahiko Yokoyama
  • A F Schier
  • R D Burdine
  • Ana Marisa Salgueiro
  • John Klingensmith
  • Wylie Vale
  • Lisa Gonçalves
  • Heike Ehmann
  • Kirsten Deissler
  • Nicholas J Justice
  • Annamaria Liguoro
  • Wolfgang H Fischer
  • Martin Blum
  • Shinsuke Chida
  • Elizabeth K Bikoff
  • Ulf K Hofmann
  • Jonathan A Kelber
  • Ana Cristina Borges
  • U Gaio
  • Stefan Britsch
  • Miriam Albrecht
  • Ursula Gaio
  • Shin Ichi Osada
  • Y T Yan
  • Peter C Gray
  • Daniela D'Andrea
  • Ryan M Anderson

Detail Information

Publications39

  1. ncbi Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1
    C Xu
    Burnham Institute, La Jolla Cancer Research Center, California 92037, USA
    Dev Biol 196:237-47. 1998
    ..Differentiation into other cell types including skeletal muscle is not disrupted. These results suggest that Cr-1 is essential for contractile cardiomyocyte formation in vitro...
  2. doi Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb
    Hidetaka Shiratori
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan Electronic address
    Dev Biol 395:331-41. 2014
    ..Although obvious defects were not apparent in the limb of mice lacking asymmetric Pitx2c expression, Pitx2c may regulate functional L-R asymmetry of the limb. ..
  3. doi Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway
    Kimberly Fuller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States
    Dev Biol 391:182-95. 2014
    ..Collectively, these data suggest that Rab23 is an essential component of the mechanism that transmits asymmetric patterning information from the node to the LPM. ..
  4. pmc The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 27:997-1002. 2013
    ..Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity...
  5. ncbi Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs
    Hidetaka Shiratori
    Developmental Genetics Group, Graduate School for Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST Yamada oka, Suita, Osaka 565 0871, Japan
    Development 133:3015-25. 2006
    ....
  6. doi Endogenous Nodal signaling regulates germ cell potency during mammalian testis development
    Cassy M Spiller
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Development 139:4123-32. 2012
    ..Thus, Nodal signaling provides a molecular control mechanism that regulates male germ cell potency in normal development and testicular cancer...
  7. pmc Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo
    Ranajeet S Saund
    Department of Neurobiology and Anatomy, University of Utah Medical School, Salt Lake City, UT 84132 3401, USA
    Development 139:2426-35. 2012
    ..Our findings suggest an essential role of endoderm cells in the signal transfer step from the node to the LPM, possibly using gap junction communication to establish the LR axis of the mouse...
  8. pmc Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway
    Yu Ting Yan
    Center for Advanced Biotechnology and Medicine and Department of Pediatric, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 22:4439-49. 2002
    ..Our findings highlight the significance of extracellular modulation of ligand activity as an important means of regulating TGF beta signaling pathways during vertebrate development...
  9. ncbi Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo
    Shinya Oki
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST Yamada oka, Suita, Osaka 565 0871, Japan
    Development 134:3893-904. 2007
    ..Transgenic rescue experiments showed that the Nodal co-receptor Cryptic (Cfc1) is required only in the LPM, not at the node, for asymmetric Nodal expression in the LPM, indicating that ..
  10. ncbi A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation
    M M Shen
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA
    Development 124:429-42. 1997
    ..We named this gene Cryptic, based on its predicted protein sequence similarity with Cripto, which encodes an EGF-related growth factor...
  11. ncbi Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development
    Olov Andersson
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Dev Biol 311:500-11. 2007
    ....
  12. pmc GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth
    Gidi Shani
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA, 92037, USA
    Mol Cell Biol 28:666-77. 2008
    ..Together, our results indicate that these proteins bind at the cell surface to enhance tumor growth via the inhibition of TGF-beta signaling...
  13. doi Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 135:501-11. 2008
    ..Collectively, our experiments establish that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse...
  14. doi Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo
    Giovanna L Liguori
    IBB Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e Estrutural, Universidade do Algarve, Campus de Gambelas, 8005 135 Faro, Portugal
    Dev Biol 315:280-9. 2008
    ..This signaling activity drives A-P axis positioning. Our results provide evidence for the existence of Cripto-independent signaling mechanisms, by which Nodal controls axis specification in the early mouse embryo...
  15. doi BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment
    Naoki Mine
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:2425-34. 2008
    ..These results indicate that BMP antagonism is required in both the node and LPM to facilitate L-R axis establishment in the mammalian embryo...
  16. doi Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner
    Akihiko Ishimura
    The 21st Century Center of Excellence COE Program, Akita University, Akita, Japan
    Dev Dyn 237:3565-76. 2008
    ..These results suggest that Man1 regulates LR asymmetry by controlling Nodal signaling in a node-independent manner...
  17. doi Left-asymmetric expression of Galanin in the linear heart tube of the mouse embryo is independent of the nodal co-receptor gene cryptic
    Axel Schweickert
    University of Hohenheim, Institute of Zoology, Stuttgart, Germany
    Dev Dyn 237:3557-64. 2008
    ..The asymmetric pattern was retained in cryptic mutant embryos, in which the Nodal signaling cascade is disrupted...
  18. doi Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate
    David R C Natale
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, Calgary, AB, Canada T2N 4N1
    Dev Biol 335:120-31. 2009
    ..These results suggest that Activin rather than TGF-beta (or Nodal) acts directly on TS cells influencing both TS cell maintenance and cell fate, depending on whether the cells are also exposed to FGF4...
  19. doi Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos
    Shinya Oki
    Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Development 136:3917-25. 2009
    ..In inv/inv embryos, this system may function in reverse as a result of ectopic production of Lefty, which inhibits the Nodal signal on the left side in a manner dependent on leftward nodal flow...
  20. pmc Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis
    Jianhua Chu
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 342:63-73. 2010
    ..We have investigated the double null mutant phenotypes for the EGF-CFC genes Cripto and Cryptic, which encode co-receptors for Nodal, and have found that they have partially redundant functions in early mouse ..
  21. pmc Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos
    Aiko Kawasumi
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 353:321-30. 2011
    ..Our results suggest that LPM is the direct target of Nodal secreted by the perinodal cells, and that an L>R distribution of active Nodal in the node is translated into the asymmetry in LPM...
  22. pmc Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation
    Y T Yan
    Center for Advanced Biotechnology and Medicine CABM and Department of Pediatrics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 13:2527-37. 1999
    ..Targeted disruption of murine Cryptic results in L-R laterality defects including randomization of abdominal situs, hyposplenia, and pulmonary right ..
  23. ncbi Role of the EGF-CFC gene cripto in cell differentiation and embryo development
    Gabriella Minchiotti
    International Institute of Genetics and Biophysics, CNR, Via Marconi 12, 80125 Naples, Italy
    Gene 287:33-7. 2002
    ..Here we review the biological role of cripto in development and differentiation, pointing out recent findings on the biochemical interactions of Cripto, Nodal and Activin-like receptors...
  24. ncbi A role of the cryptic gene in the correct establishment of the left-right axis
    U Gaio
    Max Delbrück Centrum for Molecular Medicine, Berlin, 13125, Germany
    Curr Biol 9:1339-42. 1999
    ..We have generated a mutant allele of cryptic, a mouse EGF-CFC gene [5]...
  25. ncbi Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis
    J F Colas
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Gene 255:205-17. 2000
    ..a new EGF-CFC gene in chick, and by comparing them with their counterparts in human (CRIPTO), mouse (cripto and cryptic), Xenopus (FRL-1) and zebrafish (one-eyed pinhead), we show that all EGF-CFC genes share an identical genomic ..
  26. ncbi Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects
    R N Bamford
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 26:365-9. 2000
    ..6) and ACVR2B (encoding activin receptor IIB; ref. 7). The EGF-CFC genes, mouse Cfc1 (encoding the Cryptic protein; ref...
  27. ncbi The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer
    D S Saloman
    Tumor Growth Factor Section, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Relat Cancer 7:199-226. 2000
    ..This multigene family consists of Xenopus FRL-1, zebrafish one-eyed-pinhead (oep), mouse cripto (Cr-1) and cryptic, and human cripto (CR-1) and criptin...
  28. ncbi Identification of differentially expressed genes in mouse development using differential display and in situ hybridization
    M M Shen
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Methods 24:15-27. 2001
    ..In principle, this strategy permits the efficient isolation of genes that are differentially expressed during early mouse embryogenesis...
  29. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 105:781-92. 2001
    ..Further, we demonstrate an absolute requirement for Hedgehog signaling in sclerotomal development and a role in cardiac morphogenesis.[Dedicated to Rosa Beddington, a pioneer in mammalian embryology]...
  30. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 106:781-92. 2001
    ..Further, we demonstrate an absolute requirement for Hedgehog signaling in sclerotomal development and a role in cardiac morphogenesis...
  31. ncbi Cripto in tumors and embryo development
    M G Persico
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125 Naples, Italy
    Biochim Biophys Acta 1552:87-93. 2001
  32. pmc Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells
    Yu Liu
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:3859-64. 2007
    ..Sox17 short-hairpin RNA blocks cardiac myogenesis non-cell autonomously and impairs the induction of Hex, a homeodomain transcription factor that is known to be required for the production of endoderm-derived heart-inducing factors...
  33. ncbi Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse
    Takeshi Fujiwara
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Ave South, Nashville, TN 37232 2175, USA
    Development 129:4685-96. 2002
    ....
  34. ncbi Left-right patterning of the mouse lateral plate requires nodal produced in the node
    Yukio Saijoh
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Osaka 565 0871, Suita, Japan
    Dev Biol 256:160-72. 2003
    ..These results indicate that Nodal produced in the node is required for expression of Nodal and other left side-specific genes in the LPM...
  35. ncbi Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
    Markus Morkel
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin, Germany
    Development 130:6283-94. 2003
    ..Our data assign a key role to beta-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation...
  36. ncbi Tcf3: a transcriptional regulator of axis induction in the early embryo
    Bradley J Merrill
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Development 131:263-74. 2004
    ..Taken together, these data reveal a unique requirement for Tcf3 repressor function in restricting induction of the anterior-posterior axis...
  37. ncbi Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
    Simon D Bamforth
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 36:1189-96. 2004
    ..We propose that an abnormal Nodal-Pitx2c pathway represents a unifying mechanism for the cardiovascular malformations observed in Cited2(-/-) mice, and that such malformations may be the sole manifestation of a laterality defect...
  38. ncbi Two nodal-responsive enhancers control left-right asymmetric expression of Nodal
    Yukio Saijoh
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST, Suita, Osaka 565 08, Japan
    Dev Dyn 232:1031-6. 2005
    ..of a conserved FoxH1-binding sequence for LSE activity and the dependence of LSE activity on Nodal coreceptor Cryptic indicate that LSE is activated by Nodal signal...
  39. pmc Wnt3a links left-right determination with segmentation and anteroposterior axis elongation
    Masa aki Nakaya
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH Frederick, MD 21702, USA
    Development 132:5425-36. 2005
    ..Thus, Wnt3a links the segmentation clock and AP axis elongation with key left-determining events, suggesting that Wnt3a is an integral component of the trunk organizer...